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antiplatelet drugs

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https://www.readbyqxmd.com/read/29929831/spontaneous-chronic-subdural-hematoma-in-elderly-people-arterial-hypertension-and-other-risk-factors
#1
Aleksandar Kostić, Ivo Kehayov, Nebojša Stojanović, Vesna Nikolov, Borislav Kitov, Predrag Milošević, Emina Kostić, Hristo Zhelyazkov
BACKGROUND: The risk factors implicated in the genesis of chronic subdural hematomas include old age, alcoholism, diabetes mellitus, arachnoid cysts, coagulopathy, anticoagulant (ACTh) and antiplatelet drugs. However, no study has reported an association between arterial hypertension (HTA) and chronic subdural hematomas. Therefore, the aim of this study was to investigate whether HTA is a risk factor for spontaneous chronic subdural hematomas (SCSDHs). METHODS: This multicenter study included patients aged over 60 years and was conducted from January 2009 to the end of 2015...
June 18, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29928849/do-antiplatelet-drugs-increase-the-risk-of-bleeding-after-dental-implant-surgery-a-case-and-crossover-study
#2
Reza Tabrizi, Isa Khaheshi, Afshin Hoseinzadeh, Babak Rezvanpour, Shervin Shafee
PURPOSE: Cessation versus continuation of antiplatelet drugs in patients undergoing dental implant surgery is a controversial issue. The present study evaluated postoperative bleeding during and after dental implant surgery in patients taking aspirin (ASA) or clopidogrel. MATERIAL AND METHODS: The present study is a case-and-crossover study. Patients who were using antiplatelet drugs and receiving 2 bilateral dental implants in the posterior region of the mandible were studied...
May 10, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29928161/the-role-of-proton-pump-inhibitors-in-the-management-of-upper-gastrointestinal-disorders
#3
Muhammad Ali Khan, Colin W Howden
Proton pump inhibitors (PPIs) have been in use since the early 1990s and play a crucial role in the management of a number of conditions affecting the upper gastrointestinal tract, including gastroesophageal reflux disease, Barrett esophagus, eosinophilic esophagitis, and dyspepsia. PPIs also play an important role in the treatment of Helicobacter pylori infection and in the prevention of upper gastrointestinal tract ulcers and bleeding among patients taking antiplatelet therapy and/or nonsteroidal anti-inflammatory drugs...
March 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29925802/possible-molecular-targets-of-novel-ruthenium-complexes-in-antiplatelet-therapy
#4
REVIEW
Thanasekaran Jayakumar, Chia-Yuan Hsu, Themmila Khamrang, Chih-Hsuan Hsia, Chih-Wei Hsia, Manjunath Manubolu, Joen-Rong Sheu
In oncotherapy, ruthenium (Ru) complexes are reflected as potential alternatives for platinum compounds and have been proved as encouraging anticancer drugs with high efficacy and low side effects. Cardiovascular diseases (CVDs) are mutually considered as the number one killer globally, and thrombosis is liable for the majority of CVD-related deaths. Platelets, an anuclear and small circulating blood cell, play key roles in hemostasis by inhibiting unnecessary blood loss of vascular damage by making blood clot...
June 20, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29924777/-vascular-stents-approaches-used-to-increase-their-clinical-efficacy
#5
K A Kuznetsov, M V Khar'kova, A A Karpenko, P P Laktionov
Using stents for endovascular restoration of blood flow made a revolution in vascular surgery, however, despite numerous variants of stents presented on the pharmacological market, there are no stents which would completely solve the problem of restenosis in the area of stent placement. In order to decrease growth of the neointima of the stented portions of vessels, stents coated with cytostatic and cytotoxic agents were worked out. To optimize the rate of drug release it was suggested to apply them in a mixture with biodegradable or biostable polymers...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924379/survival-benefit-from-recent-changes-in-management-of-men-and-women-with-st-elevation-myocardial-infarction-treated-with-percutaneous-coronary-interventions
#6
Łukasz Zandecki, Marcin Sadowski, Marianna Janion, Jacek Kurzawski, Marek Gierlotka, Lech Poloński, Mariusz Gąsior
BACKGROUND: Nowadays, the majority of patients with myocardial infarction with ST-segment elevation (STEMI) are treated with primary percutaneous coronary interventions (pPCI). In recent years, there have been ongoing improvements in PCI techniques, devices and concomitant pharmacotherapy. However, reports on further mortality reduction among PCI-treated STEMI patients remain inconclusive. The aim of this study was to compare changes in management and mortality in PCI-treated STEMI patients between 2005 and 2011 in a real-life setting...
June 20, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29914573/stent-thrombosis-associated-with-drug-eluting-stents-on-addition-of-cilostazol-to-the-standard-dual-antiplatelet-therapy-following-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis-of-published-randomized-controlled-trials
#7
Feng Huang
BACKGROUND: In this analysis, we aimed to systematically compare stent thrombosis (ST) and its different subtypes following treatment with DAPT (aspirin + clopidogrel) versus TAPT (aspirin + clopidogrel + cilostazol). METHODS: Studies were included if: they were randomized controlled trials (RCTs) comparing TAPT (cilostazol + aspirin + clopidogrel) with DAPT (aspirin + clopidogrel); they reported ST or its subtype including definite, probable, acute, sub-acute and late ST as their clinical outcomes...
June 18, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29914049/anticoagulant-activities-of-indobufen-an-antiplatelet-drug
#8
Jia Liu, Dan Xu, Nian Xia, Kai Hou, Shijie Chen, Yu Wang, Yunman Li
Indobufen is a new generation of anti-platelet aggregation drug, but studies were not sufficient on its anticoagulant effects. In the present study, the anticoagulant activity of indobufen was determined by monitoring the activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) in rabbit plasma. We evaluated the anticoagulant mechanisms on the content of the platelet factor 3,4 (PF3,4), and the coagulation factor 1, 2, 5, 8, 10 (FI, II, V, VIII, X) in rabbits, as well as the in vivo bleeding time and clotting time in mice...
June 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29908967/platelet-reactivity-and-risk-of-ischemic-stroke-after-coronary-drug-eluting-stent-implantation-from-the-adapt-des-study
#9
Gennaro Giustino, Björn Redfors, Ajay J Kirtane, Roxana Mehran, George D Dangas, Bernhard Witzenbichler, Franz-Josef Neumann, Giora Weisz, Philippe Généreux, Akiko Maehara, Thomas McAndrew, Serdar Farhan, Michael J Rinaldi, D Christopher Metzger, Timothy D Henry, David A Cox, Peter L Duffy, Ernest L Mazzaferri, Bruce R Brodie, Thomas D Stuckey, Paul Gurbel, Ori Ben-Yehuda, Gregg W Stone
OBJECTIVES: The authors sought to investigate the association between P2Y12 reaction units (PRU) and the risk of ischemic stroke (IS) after successful coronary drug-eluting stents (DES) implantation. BACKGROUND: The association between platelet reactivity on clopidogrel and the risk for ischemic cerebrovascular events remains unclear. METHODS: Incidence, predictors, and prognostic impact of IS were evaluated among patients enrolled in the multicenter, prospective ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents) study...
June 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29898848/oral-anti-xa-anticoagulation-after-trans-aortic-valve-implantation-for-aortic-stenosis-the-randomized-atlantis-trial
#10
Jean-Philippe Collet, Sergio Berti, Angel Cequier, Eric Van Belle, Thierry Lefevre, Pascal Leprince, Franz-Josef Neumann, Eric Vicaut, Gilles Montalescot
BACKGROUND: Antithrombotic treatment regimen following transcatheter aortic valve replacement (TAVR) is not evidence-based. Apixaban, a non-vitamin K direct anticoagulant (NOAC) was shown to be superior to VKA and superior to aspirin to prevent cardioembolic stroke in non-valvular atrial fibrillation. It may have the potential to reduce TAVR-related thrombotic complications including subclinical valve thrombosis along with a better safety than the standard of care. DESIGN: ATLANTIS is a multicenter, randomized, phase IIIb, prospective, open-label, superiority study comparing standard of care (SOC Group) versus an apixaban-based strategy (Anti-Xa Group) after successful TAVR (ClinicalTrials...
June 2018: American Heart Journal
https://www.readbyqxmd.com/read/29894993/transbronchial-lung-cryobiopsy-in-interstitial-lung-diseases-best-practice
#11
Sara Colella, Maik Haentschel, Pallav Shah, Venerino Poletti, Jürgen Hetzel
The lung biopsy in interstitial lung disease (ILD) represents an important diagnostic step when the clinical and radiological data are insufficient for a firm diagnosis. A growing body of evidence suggests the utility of transbronchial lung cryobiopsy (TBLC) in the diagnostic algorithm of ILD as it allows, compared to transbronchial lung biopsy with conventional forceps, a better identification of complex histological patterns - such as usual interstitial pneumonia - and can provide information which has a clinical impact on the multidisciplinary discussion similar to that provided by surgical lung biopsy...
June 12, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29888274/difference-between-the-upper-and-the-lower-gastrointestinal-bleeding-in-patients-taking-nonvitamin-k-oral-anticoagulants
#12
Kyohei Maruyama, Takatsugu Yamamoto, Hitoshi Aoyagi, Akari Isono, Koichiro Abe, Shinya Kodashima, Hiroto Kita, Yuji Watari, Ken Kozuma
Nonvitamin K oral anticoagulants (NOACs) sometimes cause hemorrhage, and the gastrointestinal tract is a common site of involvement. However, clinical characteristics of gastrointestinal bleeding (GIB) during NOAC therapy have not been fully elucidated. We studied 658 patients who were prescribed dabigatran, rivaroxaban, or apixaban between April 2011 and November 2015. Medical charts were reviewed to examine whether clinically relevant bleeding (Bleeding Academic Research Consortium criteria type 2 or greater) developed...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29887934/inhibition-of-high-shear-arterial-thrombosis-by-charged-nanoparticles
#13
Michael T Griffin, Yuanzheng Zhu, Zixiang Liu, Cyrus K Aidun, David N Ku
Platelet accumulation under high shear rates at the site of atherosclerotic plaque rupture leads to myocardial infarction and stroke. Current antiplatelet therapies remain ineffective within a large percentage of the population, while presenting significant risks for bleeding. We explore a novel way to inhibit arterial thrombus formation by biophysical means without the use of platelet inactivating drugs. Our computational multi-scale dynamics model has predicted that charged particles of a specific size may entangle von Willebrand Factor (vWF) polymers and reduce the amount of elongation at high shear rates...
July 2018: Biomicrofluidics
https://www.readbyqxmd.com/read/29883853/monoclonal-antibodies-as-immunomodulatory-therapy-against-cancer-and-autoimmune-diseases
#14
REVIEW
Umbreen Hafeez, Hui K Gan, Andrew M Scott
Since Nobel laureate Paul Ehrlich proposed the concept of magic bullet in 1906, Köhler and Milstein discovered Hybridoma technology in 1975, and Greg Winter pioneered the technique to humanize monoclonal antibodies in 1988, monoclonal antibodies have been successfully developed to treat medical illnesses. Monoclonal antibodies are effective treatments for inhibition of alloimmune reactivity, haematological malignancies, solid organ malignancies, viral illnesses and are also used as antiplatelet therapy. Their successful use in cancer and autoimmune diseases in humans have made them one of the fastest growing classes of new drugs approved for these indications in last few decades...
June 5, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29877670/blood-pressure-control-in-older-patients-with-carotid-artery-stenosis
#15
Pompilio Faggiano, Marta Scodro, Marco Sbolli, Luca Branca, Dario Cani, Francesca Valentini, Carlotta Perego, Martino Provini
Stroke is the second largest cause of European cardiovascular and total mortality, largely due to atherosclerotic carotid artery narrowing or thromboembolism consequent to internal carotid artery stenosis. Current therapeutic indications suggest lifestyle interventions (smoking cessation, healthy diet and physical activity), adequate control of LDL-cholesterol and glycemic balance. It is nonetheless established that the most important factors in preventing stroke are antiplatelet therapy and blood pressure regulation...
June 7, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29877182/potentially-inappropriate-prescribing-in-elderly-patient-analyze-before-after-hospitalization
#16
Ludovic Argoullon, Marie-Agnès Manciaux, Aude Valance, Amélie Bonneville
In the context of improved medication management in the elderly patient, we were interested in the reevaluation of drug prescription during hospitalization. The aim of this study is to assess the prevalence of inappropriate prescribing in the elderly patient before and after hospitalization. PATIENTS AND METHODS: This is a descriptive and retrospective study of drug prescriptions in a non-geriatric unit. Prescriptions were analyzed using STOPP/START tool. RESULTS: Seventy-two patients over 65 years-old were included...
June 1, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/29874954/prolonged-use-of-eptifibatide-as-a-bridge-to-maintain-drug-eluting-stent-patency-in-a-patient-receiving-extracorporeal-membrane-oxygenation
#17
Payal K Gurnani, Allison Bohlmann, Robert J March
BACKGROUND: Venoarterial extracorporeal membrane oxygenation (VA-ECMO) has been used as a bridge to cardiac recovery in patients following a major cardiac event. There is a lack of literature surrounding prolonged use of eptifibatide and optimal dosing during ECMO. This case report describes our experience with extended durations and standard dosing of eptifibatide in the setting of ECMO. CASE: A 40-year-old male with a history of Marfan's syndrome, aortic root and ascending aortic aneurysm status post a modified Bentall with a St...
June 1, 2018: Perfusion
https://www.readbyqxmd.com/read/29870382/bleeding-severity-after-percutaneous-coronary-intervention
#18
Björn Redfors, Philippe Généreux, Bernhard Witzenbichler, Ajay J Kirtane, Thomas McAndrew, Giora Weisz, Thomas D Stuckey, Timothy D Henry, Akiko Maehara, Roxana Mehran, Gregg W Stone
BACKGROUND: In-hospital bleeding after percutaneous coronary intervention is associated with increased mortality. We studied the impact of bleeding severity, defined as magnitude of Hgb (hemoglobin) reduction from baseline (ΔHgb), on the risk of death and other adverse events. METHODS AND RESULTS: We studied the association between ΔHgb, baseline characteristics, and outcomes among 7608 patients in the ADAPT-DES registry (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) who had information on Hgb values before and after they underwent successful percutaneous coronary intervention...
March 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29870380/the-case-for-selective-patent-foramen-ovale-closure-after-cryptogenic-stroke
#19
REVIEW
Dominik M Wiktor, John D Carroll
Controversy has persisted for over a decade whether transcatheter patent foramen ovale (PFO) closure reduces the rate of recurrent ischemic stroke for patients who have had a cryptogenic ischemic stroke and have a PFO. In September 2017, 3 positive randomized trials: RESPECT long-term (Recurrent Stroke Comparing PFO Closure to Established Current Standard of Care Treatment trial), REDUCE (GORE® HELEX® Septal Occluder / GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke or Imaging-Confirmed TIA in Patients With Patent Foramen Ovale [PFO]), and CLOSE (Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence) were published...
March 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29869943/the-effects-of-aspirin-and-ticagrelor-on-toll-like-receptor-tlr-mediated-platelet-activation-results-of-a-randomized-cross-over-trial
#20
Kathryn E Hally, Anne C La Flamme, Scott A Harding, Peter D Larsen
Platelet activation underlies the pathology of an acute myocardial infarction (AMI), and dual antiplatelet therapy (DAPT) is administered post-AMI to limit this activation. Platelets express Toll-like receptors (TLRs) 1, 2, and 4 and become potently activated in response to TLR2/1 and TLR4 stimulation. However, it is unknown whether antiplatelet agents can protect against platelet activation via these TLR pathways. This study aimed to determine the extent to which TLR-mediated platelet activation can be inhibited by currently used antiplatelet agents...
June 5, 2018: Platelets
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