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https://www.readbyqxmd.com/read/29035892/patent-foramen-ovale-as-possible-cause-of-sudden-sensorineural-hearing-loss-a-case-report
#1
Andrea Ciorba, Virginia Corazzi, Luca Cerritelli, Chiara Bianchini, Giovanni Scanelli, Claudia Aimoni
OBJECTIVE: To present a case of sudden sensorineural hearing loss (SSNHL) and the related diagnostic work-up. CLINICAL PRESENTATION AND INTERVENTION: A 54-year-old man presented with unilateral SSNHL episode and vertigo. A severe patent foramen ovale (PFO) that included a complete ear nose and throat, audiological and neurological examination was discovered during the diagnostic work-up. Audiometry, blood and serological tests were performed. Magnetic resonance imaging (MRI), supra-aortic trunks and lower limbs color Doppler echography were done...
October 16, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29035427/differences-in-the-korea-acute-myocardial-infarction-registry-compared-with-western-registries
#2
REVIEW
Doo Sun Sim, Myung Ho Jeong
The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29032760/9-4-dimethylaminophenyl-2-6-7-trihydroxy-xanthene-3-one-is-a-potentially-novel-antiplatelet-drug-which-antagonizes-the-effect-of-thromboxane-a2
#3
Lenka Applova, Elma Veljovic, Samija Muratovic, Jana Karlickova, Katerina Macakova, Davorka Završnik, Luciano Saso, Kemal Duric, Premysl Mladenka
BACKGROUND: Currently used oral antiplatelet drugs are both limited and associated with risk of treatment failure/resistance. Research in this area is hence highly desired. A series of xanthene-3-ones derivatives, we had synthesized, showed us that these derivatives had antiplatelet activity. As far as we know, no research on the effects of xanthen-3-ones in this area has been done. OBJECTIVE: The aim was to study the antiplatelet potential of a series of synthesised 9-phenyl-xanthene-3-ones and to find the ideal structural feature(s) for antiplatelet potential and determine the mechanism of action...
October 10, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/29025834/study-protocol-for-a-randomised-controlled-trial-harmonising-optimal-strategy-for-treatment-of-coronary-artery-stenosis-coronary-intervention-with-next-generation-drug-eluting-stent-platforms-and-abbreviated-dual-antiplatelet-therapy-host-idea-trial
#4
Chi-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Namho Lee, Tae-Joon Cha, Tae-Hyun Yang, Myung-Ho Jeong, Myeong-Ho Yoon, Seung Uk Lee, Seung Jin Lee, Jin Won Kim, Jin-Man Cho, Kyu-Rock Han, Wook Bum Pyun, Hyo-Soo Kim
INTRODUCTION: We have recently seen the introduction of newer generation drug-eluting stents with ultrathin struts that use advanced polymer technologies. However, the efficacy and safety of these newest stents have not yet been fully explored. In addition, there are still controversies over the optimal duration of dual antiplatelet therapy (DAPT) after stent implantation, particularly for ultrathin stents with the newest polymer technologies. METHODS AND ANALYSIS: The HOST-IDEA trial is a randomised, open-label, multicentre, non-inferiority trial and the first study to directly compare two of these ultrathin sirolimus-eluting stents: Orsiro stent with biodegradable polymer, and polymer-free Coroflex ISAR (CX-ISAR) stent...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29023526/antithrombotic-therapy-strategies-for-atrial-fibrillation-patients-undergoing-percutaneous-coronary-intervention-a-systematic-review-and-network-meta-analysis
#5
Xiaoxuan Gong, Shaowen Tang, Jiangjin Li, Xiwen Zhang, Xiaoyi Tian, Shuren Ma
OBJECTIVE: The aim of this systematic review and network meta-analysis was to evaluate the comparative efficacy and safety of antiplatelet agents, vitamin K antagonist (VKA) and non-VKA oral anticoagulants (NOACs) in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI). METHODS: PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials were searched to identify clinical trials comparing antiplatelet drugs with VKA and NOACs or their combination in AF patients undergoing PCI with a mean/median follow-up of at least 12 months...
2017: PloS One
https://www.readbyqxmd.com/read/29022745/real-world-adherence-to-oral-anticoagulant-in-non-valvular-atrial-fibrillation-patients-in-china
#6
Xiao Xiang, Yaying Cao, Kexin Sun, Jing Song, Yaohua Tian, Qiongzhou Yin, Juan Juan, Yonghua Hu
BACKGROUND AND OBJECTIVE: Adherence to oral anticoagulants is crucial for the prevention of ischemic stroke in atrial fibrillation patients; however, evidence of oral-anticoagulant adherence from developing countries is still lacking. Our study aimed to evaluate the current situation and predictors of oral-anticoagulant adherence in non-valvular atrial fibrillation (NVAF) patients in China. METHODS: Records of NVAF patients were obtained from a regional claims database...
October 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29020490/impact-of-ticagrelor-on-p2y1-and-p2y12-localization-and-on-cholesterol-levels-in-platelet-plasma-membrane
#7
Vahideh Rabani, Damien Montange, Nicolas Meneveau, Siamak Davani
Ticagrelor is an antiplatelet agent that inhibits platelet activation via P2Y12 antagonism. There are several studies showing that P2Y12 needs lipid rafts to be activated, but there are few data about how ticagrelor impacts lipid raft organization. Therefore, we aimed to investigate how ticagrelor could impact the distribution of cholesterol and consequently alter the organization of lipid rafts on platelet plasma membranes. We identified cholesterol-enriched raft fractions in platelet membranes by quantification of their cholesterol levels...
October 11, 2017: Platelets
https://www.readbyqxmd.com/read/29020300/impact-of-design-of-coronary-stents-and-length-of-dual-antiplatelet-therapies-on-ischaemic-and-bleeding-events-a-network-meta-analysis-of-64-randomized-controlled-trials-and-102%C3%A2-735-patients
#8
Fabrizio D'Ascenzo, Mario Iannaccone, Gaelle Saint-Hilary, Maurizio Bertaina, Stefanie Schulz-Schüpke, Cheol Wahn Lee, Alaide Chieffo, Gerard Helft, Sebastiano Gili, Umberto Barbero, Giuseppe Biondi Zoccai, Claudio Moretti, Fabrizio Ugo, Maurizio D'Amico, Roberto Garbo, Gregg Stone, Sara Rettegno, Pierluigi Omedè, Federico Conrotto, Christian Templin, Antonio Colombo, Seung-Jung Park, Adnan Kastrati, David Hildick-Smith, Mauro Gasparini, Fiorenzo Gaita
Aims: The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results: Randomized controlled trials comparing different types of DES and/or DAPT durations were selected. The primary endpoint was Major Adverse Cardiovascular Events (MACE) [a composite of death, myocardial infarction (MI), and target vessel revascularization]...
August 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29016553/bleeding-and-neurologic-complications-in-58-000-interventional-pain-procedures
#9
Nafisseh S Warner, W Michael Hooten, Matthew A Warner, Tim J Lamer, Jason S Eldrige, Halena M Gazelka, Daryl J Kor, Bryan C Hoelzer, William D Mauck, Susan M Moeschler
BACKGROUND AND OBJECTIVES: Interventional pain procedures are commonly performed on patients receiving antiplatelet therapy. However, there is limited evidence to support or refute the safety of this practice. The goal of this investigation was to assess the rate of bleeding complications in a large cohort of patients undergoing intermediate- and low-risk pain procedures, with a specific focus on antiplatelet and anticoagulant medication use and baseline coagulation abnormalities. METHODS: This is a retrospective cohort study of adult patients undergoing low- and intermediate-risk pain procedures from 2005 through 2014 by the division of pain medicine at a single academic tertiary care center...
October 6, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29016367/updates-in-nutrition-and-polypharmacy
#10
Milta O Little
PURPOSE OF REVIEW: Medications have the potential to affect nutritional status in negative ways, especially as the number of medications increase. The inter-relation between polypharmacy and malnutrition is complex and not fully delineated in previous studies. More research has been done and compiled in the last year, which helps to clarify this relationship. This review brings together the most recent literature with the previous research to help healthcare providers to better assess and manage medication therapy in older adults...
October 7, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28994036/comparison-of-4-different-strategies-of-dapt-after-pci-in-acs-real-world-population-from-a-northern-italy-registry
#11
Marta Rasia, Emilia Solinas, Massimiliano Marino, Paolo Guastaroba, Alberto Menozzi, Maria Alberta Cattabiani, Iacopo Tadonio, Rossana De Palma, Luigi Vignali
Aim of the study was to compare four different strategies of dual antiplatelet therapy (DAPT) in patients with acute coronary syndromes (ACS) treated with PCI. DAPT with Clopidogrel, Ticagrelor and Prasugrel has proved to be effective in patients with ACS treated with percutaneous coronary intervention (PCI) by reducing major adverse cardiovascular outcomes (MACE). However, the effect of the different strategies in a real-world population deserves further verification. A retrospective analysis of 2404 discharged ACS patients treated with PCI was performed, with a median follow-up of 1 year...
October 9, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28990360/effects-of-genetic-variants-on-carboxylesterase-1-gene-expression-and-clopidogrel-pharmacokinetics-and-antiplatelet-effects
#12
Mikko Neuvonen, E Katriina Tarkiainen, Aleksi Tornio, Päivi Hirvensalo, Tuija Tapaninen, Maria Paile-Hyvärinen, Matti K Itkonen, Mikko T Holmberg, Vesa Kärjä, Ville T Männistö, Pertti J Neuvonen, Jussi Pihlajamäki, Janne T Backman, Mikko Niemi
Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample cohorts of 192 (discovery) and 88 (replication) healthy volunteers and in a liver sample cohort of 177 patients. Furthermore, we investigated possible effects of the found variants on clopidogrel pharmacokinetics (n=106) and pharmacodynamics (n=46) in healthy volunteers, who had ingested a single 300 mg or 600 mg dose of clopidogrel...
October 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28982692/validating-utility-of-dapt-score-in-a-large-pooled-cohort-from-three-japanese-pci-studies
#13
Yusuke Yoshikawa, Hiroki Shiomi, Hirotoshi Watanabe, Masahiro Natsuaki, Hirokazu Kondo, Toshihiro Tamura, Yoshihisa Nakagawa, Takeshi Morimoto, Takeshi Kimura
Background -The DAPT score was developed to estimate ischemic and bleeding risks from the DAPT (Dual Antiplatelet Therapy) study. However, few studies validated its utility externally. We sought to validate the utility of the DAPT score in Japanese population. Methods -In a pooled cohort of three studies conducted in Japan (the CREDO Kyoto registry cohort-2, RESET and NEXT), we compared risks for ischemic and bleeding events from 13 to 36 months after percutaneous coronary intervention (PCI) between patients with DAPT score ≥2 (high-DS) and DAPT score <2 (low-DS)...
October 5, 2017: Circulation
https://www.readbyqxmd.com/read/28981961/contemporary-use-of-oral-antithrombotic-agents-focus-on-dual-and-triple-therapeutic-approaches
#14
Antoine T Jenkins, Alexander Kantorovich, Luba Burman
Atherosclerotic cardiovascular disease (ASCVD) represents a long-standing health care burden in most industrialized countries. Management of ASCVD is multifaceted, and utilization of antithrombotic agents is a key component of care in order to reduce vascular events. Minimizing thrombotic risk can be accomplished via antiplatelet or anticoagulant drugs; however, combination therapy is warranted for some indications. Although reducing thrombotic complications is important, it is equally vital to consider the safety of combination regimens...
October 5, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28980280/renin-angiotensin-system-inhibition-is-associated-with-reduced-risk-of-left-atrial-appendage-thrombosis-formation-in-patients-with-atrial-fibrillation
#15
Ya Suo, Yue Zhang, Yuanyuan Wang, Meng Yuan, Sayuri Kariyawasam, Gary Tse, Tong Liu, Huaying Fu, Guangping Li
BACKGROUND: Inhibition of the renin-angiotensin axis can reduce the likelihood of atrial fibrillation (AF). However, the effects of angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) on thrombogenicity in AF remain incompletely elucidated. Thisretrospective case-control study was conducted to evaluate whether the use of ACEI or ARB could reduce the incidence of left atrial appendage thrombus (LAAT) and spontaneous echocardiographic contrast (SEC) in patients with AF...
October 5, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28979304/rp-hplc-method-development-and-validation-for-determination-of-eptifibatide-acetate-in-bulk-drug-substance-and-pharmaceutical-dosage-forms
#16
Maryam Bavand Savadkouhi, Hossein Vahidi, Abdul Majid Ayatollahi, Shirin Hooshfar, Farzad Kobarfard
A new, rapid, economical and isocratic reverse phase high performance liquid chromatography (RP-HPLC) method was developed for the determination of eptifibatide acetate, a small synthetic antiplatelet peptide, in bulk drug substance and pharmaceutical dosage forms. The developed method was validated as per of ICH guidelines. The chromatographic separation was achieved isocratically on C18 column (150 x 4.60 mm i.d., 5 µM particle size) at ambient temperature using acetonitrile (ACN), water and trifluoroacetic acid (TFA) as mobile phase at flow rate of 1 mL/min and UV detection at 275 nm...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28976875/antiplatelet-therapy-in-a-patient-with-coronary-artery-disease-and-myelodysplastic-syndrome-with-thrombocytopenia
#17
Francisco José Fernández-Fernández, Eugenia Ameneiros-Lago, Cintia Tuñas-Gesto, Inmaculada Gómez-Buela
To date, there are no sufficient data to make firm recommendations on the treatment of patients with severe thrombocytopenia who require antiplatelet therapy after experiencing acute coronary syndrome. Therefore, we think that it is important to communicate the experience with individual cases. We report the case of a patient who presented with pericardial effusion causing cardiac tamponade. He had thrombocytopenia associated with myelodysplastic syndrome, and ten weeks before this admission, percutaneous transluminal coronary angioplasty with implantation of drug-eluting stents was performed for non-ST-segment elevation acute coronary syndrome...
2017: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/28976391/-antithrombotic-therapy-in-the-elderly-are-there-differences
#18
Mahmut Şahin
Atherothrombotic disease increase with age and that the prevalence of the elderly population is continuously growing. Antithrombotic therapy represents the cornerstone of prevention of atherothrombosis. The choice of the antithrombotic therapy in elderly patients remains an ongoing challenge. Althoug the benefits of antiplatelet therapy in the elderly are demonstrated, the elderly are generally more vulnerable to the adverse effects of antithrombotic drugs. Because of them, understanding strategies of antithrombotic management in elderly is important...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28973248/association-between-use-of-antithrombotic-medication-and-hematuria-related-complications
#19
COMPARATIVE STUDY
Christopher J D Wallis, Tristan Juvet, Yuna Lee, Rano Matta, Sender Herschorn, Ronald Kodama, Girish S Kulkarni, Raj Satkunasivam, William Geerts, Anne McLeod, Steven A Narod, Robert K Nam
Importance: Antithrombotic medications are among the most commonly prescribed medications. Objective: To characterize rates of hematuria-related complications among patients taking antithrombotic medications. Design, Setting, and Participants: Population-based, retrospective cohort study including all citizens in Ontario, Canada, aged 66 years and older between 2002 and 2014. The final follow-up date was December 31, 2014. Exposures: Receipt of an oral anticoagulant or antiplatelet medication...
October 3, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28969559/genetic-signatures-in-ischemic-stroke-focus-on-aspirin-resistance
#20
Anjana Munshi, Kanika Vasudeva, Pratibha Chaurasia, Sulena Singh
Stroke is one of the leading causes of death. There has been compelling evidence that stroke has a genetic component. Genetic variants not only influence susceptibility to stroke but have also been found to alter the response to pharmacological agents and influence the clinical outcome of the disease. Stroke patients are treated with antiplatelet drugs like aspirin and clopidogrel to prevent a secondary stroke. Inspite the fact that many new antiplatelet drugs have been developed; aspirin is still considered as a golden standard for the antiplatelet therapy...
October 2, 2017: CNS & Neurological Disorders Drug Targets
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