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https://www.readbyqxmd.com/read/28107500/diagnostic-efficacy-of-sentinel-lymph-node-biopsy-in-early-oral-squamous-cell-carcinoma-a-meta-analysis-of-66-studies
#1
Muyuan Liu, Steven J Wang, Xihong Yang, Hanwei Peng
OBJECTIVES: The diagnostic efficacy of sentinel lymph node biopsy(SLNB) in early oral squamous cell carcinoma(OSCC) still remains controversial. This meta-analysis was conducted to assess the diagnostic value of SLNB in clinically neck-negative T1-2 OSCC. METHODS: A systematic literature search for relevant literature published up to September 11, 2016 was conducted in PubMed, Embase, Web of Science, Cochrane Library and ClinicalTrials, and the reference lists of eligible studies were examined...
2017: PloS One
https://www.readbyqxmd.com/read/28106675/treatment-of-slipped-capital-femoral-epiphysis-with-the-modified-dunn-procedure-a-multicenter-study
#2
Masquijo J Javier, Allende Victoria, D'Elia Martín, Miranda Gabriela, Fernández Claudio A
INTRODUCTION: Treatment of moderate to severe slipped capital femoral epiphysis (SCFE) is controversial. Over the last years, 3 institutions in Argentina adopted the modified Dunn procedure for capital realignment in selected cases of SCFE. Our aim in this study was to evaluate the clinical outcome and the rate of complications of patients who had undergone surgical hip dislocation and capital realignment. METHODS: A multicenter retrospective cohort study of patients who received the modified Dunn procedure from January 2009 to 2013 was performed...
January 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28102457/prevalence-of-vertebral-fracture-and-densitometric-osteoporosis-in-spanish-adult-men-the-camargo-cohort-study
#3
José M Olmos, José L Hernández, Josefina Martínez, Emilio Pariente, Jesús Castillo, Daniel Prieto-Alhambra, Jesús González-Macías
The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA at the lumbar spine, femoral neck and total hip. Vertebral fractures were assessed by lateral thoracic and lumbar spine radiographs. The prevalence of osteoporosis was estimated with both the World Health Organization (WHO) (T-score of <-2...
January 19, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28098823/integrative-mirna-gene-expression-analysis-enables-refinement-of-associated-biology-and-prediction-of-response-to-cetuximab-in-head-and-neck-squamous-cell-cancer
#4
Loris De Cecco, Marco Giannoccaro, Edoardo Marchesi, Paolo Bossi, Federica Favales, Laura D Locati, Lisa Licitra, Silvana Pilotti, Silvana Canevari
This paper documents the process by which we, through gene and miRNA expression profiling of the same samples of head and neck squamous cell carcinomas (HNSCC) and an integrative miRNA-mRNA expression analysis, were able to identify candidate biomarkers of progression-free survival (PFS) in patients treated with cetuximab-based approaches. Through sparse partial least square-discriminant analysis (sPLS-DA) and supervised analysis, 36 miRNAs were identified in two components that clearly separated long- and short-PFS patients...
January 14, 2017: Genes
https://www.readbyqxmd.com/read/28094412/ultrasound-guided-approach-to-the-cervical-articular-process-joints-in-horses-a-validation-of-the-technique-in-cadavers
#5
Jessica Purefoy Johnson, John David Stack, Conor Rowan, Ian Handel, John Mark O'Leary
OBJECTIVES: To compare accuracy of the ultrasound-guided craniodorsal (CrD) approach with the dorsal (D) approach to the cervical articular process joints, and to evaluate the effect of transducer, needle gauge, and operator experience. METHODS: Cervical articular process joints from 14 cadaveric neck specimens were injected using either a D or CrD approach, a linear (13 MHx) or microconvex transducer (10 MHz), and an 18 or 20 gauge needle, by an experienced or inexperienced operator...
January 17, 2017: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/28091968/load-based-lower-neck-injury-criteria-for-females-from-rear-impact-from-cadaver-experiments
#6
Narayan Yoganandan, Frank A Pintar, Anjishnu Banerjee
The objectives of this study were to derive lower neck injury metrics/criteria and injury risk curves for the force, moment, and interaction criterion in rear impacts for females. Biomechanical data were obtained from previous intact and isolated post mortem human subjects and head-neck complexes subjected to posteroanterior accelerative loading. Censored data were used in the survival analysis model. The primary shear force, sagittal bending moment, and interaction (lower neck injury criterion, LNic) metrics were significant predictors of injury...
January 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28091733/post-treatment-pet-ct-and-p16-status-for-predicting-treatment-outcomes-in-locally-advanced-head-and-neck-cancer-after-definitive-radiation
#7
Musaddiq J Awan, Pierre Lavertu, Chad Zender, Rod Rezaee, Nicole Fowler, Lilit Karapetyan, Michael Gibson, Jay Wasman, Peter Faulhaber, Mitchell Machtay, Min Yao
PURPOSE: To retrospectively review post-treatment (post-tx) FDG-PET/CT scans in patients with advanced head and neck squamous cell carcinoma (HNSCC) and known p16 status, treated with definitive (chemo)radiation (RT). METHODS: A total of 108 eligible patients had N2A or greater HNSCC treated with chemoRT from August 1, 2008, to February 28, 2015, with post-tx PET/CT within 6 months after RT. Kaplan-Meier curves, log-rank statistics, and Cox proportional hazards regression were used for statistical analysis...
January 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28081584/-mini-open-approach-shows-good-results-in-treatment-of-femoroacetabular-impingement
#8
Stephanie Maria Kirschbaum, Frank Sitterlee, Carsten Perka, Michael Müller
Background Femoroacetabular impingement (FAI) describes a painful, abnormal (bony) contact between the femoral neck and acetabulum, which, if left untreated, contributes to early osteoarthritis (OA) of the hip. Despite its flat learning curve and long operation times, hip arthroscopy has been used increasingly often in recent years in the surgery of femoroacetabular impingement. The mini-open technique (MOT) offers a possible alternative that addresses the abnormal morphological prominence and allows minimally invasive clearance of hip motion...
January 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28076630/cutoffs-and-cardiovascular-risk-factors-associated-with-neck-circumference-among-community-dwelling-elderly-adults-a-cross-sectional-study
#9
Hélio José Coelho, Ricardo Aurélio Carvalho Sampaio, Ivan de Oliveira Gonçalvez, Samuel da Silva Aguiar, Rafael Palmeira, José Fernando de Oliveira, Ricardo Yukio Asano, Priscila Yukari Sewo Sampaio, Marco Carlos Uchida
CONTEXT AND OBJECTIVE: In elderly people, measurement of several anthropometric parameters may present complications. Although neck circumference measurements seem to avoid these issues, the cutoffs and cardiovascular risk factors associated with this parameter among elderly people remain unknown. This study was developed to identify the cutoff values and cardiovascular risk factors associated with neck circumference measurements among elderly people. DESIGN AND SETTING: Cross-sectional study conducted in two community centers for elderly people...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28058553/implications-of-sentinel-lymph-node-drainage-to-multiple-basins-in-head-and-neck-melanoma
#10
Camille L Stewart, Ana Gleisner, Jennifer Kwak, Brandon Chapman, Nathan Pearlman, Csaba Gajdos, Martin McCarter, Nicole Kounalakis
BACKGROUND: Sentinel lymph node biopsy (SLNB) for head and neck melanoma is challenging due to unpredictable drainage. We sought to determine the frequency of drainage to multiple lymphatic basins and asked if this was associated with prognosis in a large, single-center cohort. METHODS: We queried patients diagnosed with head and neck melanomas who had a SLNB performed from January 1998 to April 2016. Demographic and clinical characteristics were compared using Student's t test, Pearson chi-square analysis, log-rank test, Wilcoxon-Mann-Whitney test, and Kaplan-Meier curves...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28054655/unique-local-bone-tissue-characteristics-in-iliac-crest-bone-biopsy-from-adolescent-idiopathic-scoliosis-with-severe-spinal-deformity
#11
Zhiwei Wang, Huanxiong Chen, Y Eric Yu, Jiajun Zhang, Ka-Yee Cheuk, Bobby K W Ng, Yong Qiu, X Edward Guo, Jack C Y Cheng, Wayne Y W Lee
Adolescent idiopathic scoliosis is a complex disease with unclear etiopathogenesis. Systemic and persistent low bone mineral density is an independent prognostic factor for curve progression. The fundamental question of how bone quality is affected in AIS remains controversy because there is lack of site-matched control for detailed analysis on bone-related parameters. In this case-control study, trabecular bone biopsies from iliac crest were collected intra-operatively from 28 severe AIS patients and 10 matched controls with similar skeletal and sexual maturity, anthropometry and femoral neck BMD Z-score to control confounding effects...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052046/fast-approximate-delivery-of-fluence-maps-for-imrt-and-vmat
#12
Marleen Balvert, David L Craft
In this article we provide a method to generate the trade-off between delivery time and fluence map matching quality for dynamically delivered fluence maps. At the heart of our method lies a mathematical programming model that, for a given duration of delivery, optimizes leaf trajectories and dose rates such that the desired fluence map is reproduced as well as possible. We begin with the single fluence map case and then generalize the model and the solution technique to the delivery of sequential fluence maps...
January 4, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28048821/mo-g-201-02-comparing-sample-size-requirements-for-knowledge-based-treatment-planning
#13
J J Boutilier, A D C Babier, T Craig, A L McNiven, M B Sharpe, T C Y Chan
PURPOSE: To compare how training set size affects the accuracy of a knowledge-based planning (KBP) model applied to prostate and head and neck (HN) cancer. METHODS: We selected a KBP model from the literature that uses distance-to-target histograms and organ volumes to predict an achievable dose-volume-histogram (DVH) curve for each organ-at-risk (OAR). We trained both the prostate and HN model using training set sizes of n=10, 20, 30, 50,75, and 100. We set aside 100 randomly selected treatment plans from each of the two respective cohorts of 218 to serve as a validation set for all experiments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048674/su-f-t-215-an-investigation-of-multi-scanner-ct-hounsfield-unit-calibration-for-pencil-beam-scanning-proton-therapy-using-3d-gamma-analysis
#14
J Zhang, X Li, G Liu, Q Liu, J Liang, X Ding
PURPOSE: We compare and investigate the dosimetric impacts on pencil beam scanning (PBS) proton treatment plans generated with CT calibration curves from four different CT scanners and one averaged 'global' CT calibration curve. METHODS: The four CT scanners are located at three different hospital locations within the same health system. CT density calibration curves were collected from these scanners using the same CT calibration phantom and acquisition parameters...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048671/su-f-t-104-determining-the-ntcp-parameters-of-pharyngeal-constrictors-and-proximal-esophagus-for-radiation-induced-swallowing-problems-recorded-six-months-after-radiation-therapy-for-head-and-neck-tumors
#15
P Mavroidis, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, S Das, L Marks, B Chera
PURPOSE: To estimate the radiobiological parameters of four NTCP models that describe the dose-response relations of pharyngeal constrictors and proximal esophagus regarding the severity of patient reported swallowing problems 6 months post chemo-radiotherapy. To identify the section/structure that best correlates with the manifestation of the clinical endpoints. Finally, to compare the goodness-of-fit of those models. METHODS: Forty-three patients were treated on a prospective multi-institutional phase II study for oropharyngeal squamous cell carcinoma...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048503/su-d-204-04-correlations-between-dosimetric-indices-and-follow-up-data-for-salivary-glands-six-months-after-radiation-therapy-for-head-and-neck-cancer
#16
B Chera, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, L Marks, S Das, P Mavroidis
PURPOSE: To investigate the correlation between different dosimetric indices of salivary glands (as separate or combined structures) to patient-reported dry mouth 6 months post radiotherapy using the novel patient reported outcome version of the CTCAE (PRO-CTCAE). METHODS: Forty-three patients with oropharyngeal squamous cell carcinoma were treated on a prospective multi-institutional study. All patients received de-intensified 60 Gy intensity modulated radiotherapy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048418/su-f-sps-10-the-dosimetric-comparison-of-gammaknife-and-cyberknife-treatment-plans-for-brain-srs-treatment
#17
E Sanli, H Mabhouti, M Cebe, G Codel, P Pacaci, E Serin, N Kucuk, E Kucukmorkoc, M Doyuran, D Canoglu, A Altinok, H Acar, H Caglar Ozkok
PURPOSE: Brain stereotactic radiosurgery (SRS) involves the use of precisely directed, single session radiation to create a desired radiobiologic response within the brain target with acceptable minimal effects on surrounding structures or tissues. In this study, the dosimetric comparison of GammaKnife perfection and Cyberknife M6 treatment plans were made. METHODS: Treatment plannings were done for GammaKnife perfection unit using Gammaplan treatment planning system (TPS) on the CT scan of head and neck randophantom simulating the treatment of sterotactic treatments for one brain metastasis...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046893/su-d-204-05-fitting-four-ntcp-models-to-treatment-outcome-data-of-salivary-glands-recorded-six-months-after-radiation-therapy-for-head-and-neck-tumors
#18
P Mavroidis, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, S Das, L Marks, B Chera
PURPOSE: To estimate the radiobiological parameters of four popular NTCP models that describe the dose-response relations of salivary glands to the severity of patient reported dry mouth 6 months post chemo-radiotherapy. To identify the glands, which best correlate with the manifestation of those clinical endpoints. Finally, to evaluate the goodness-of-fit of the NTCP models. METHODS: Forty-three patients were treated on a prospective multiinstitutional phase II study for oropharyngeal squamous cell carcinoma...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046821/su-g-201-07-dosimetric-verification-of-a-3d-printed-hdr-skin-brachytherapy-applicator
#19
K Rasmussen, A Baumgarten, D Stanley, C Pelletier, M Corbett, J Jung, Y Feng, Z Huang, A Ju, T Eng, N Kirby, A Gutierrez, S Stathakis, N Papanikolaou
PURPOSE: The use of radiation as a treatment modality for skin cancer has increased significantly over the last decade with standardized applicators. Utilizing 3D printing, the ability to make applicators specifically designed for each patient's anatomy has become economically feasible. With this in mind it was the aim of this study to determine the dosimetric accuracy of a 3-D printed HDR brachytherapy applicator for the skin. METHODS: A CT reference image was used to generate a custom applicator based on an anthropomorphic head and neck phantom...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046674/su-f-t-107-correlations-between-dosimetric-indices-of-pharyngeal-constrictors-and-proximal-esophagus-with-associated-patient-reported-outcomes-six-months-after-radiation-therapy-for-head-and-neck-cancer
#20
B Chera, A Price, M Kostich, R Amdur, W Mendenhall, N Sheets, R Green, L Marks, S Das, P Mavroidis
PURPOSE: To compare the correlations between different dosimetric indices derived from the pharyngeal constrictor muscles and proximal esophagus with patient-reported difficulty in swallowing 6 months post radiotherapy using a novel patient reported outcome version of CTCAE (PRO-CTCAE). METHODS: Forty-three patients with oropharyngeal squamous cell carcinoma were treated on a prospective multi-institutional study. All patients received de-intensified 60 Gy intensity modulated radiotherapy...
June 2016: Medical Physics
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