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https://www.readbyqxmd.com/read/29779936/early-response-assessment-on-mid-treatment-computed-tomography-predicts-for-locoregional-recurrence-in-oropharyngeal-cancer-patients-treated-with-definitive-radiation-therapy
#1
Rafi Kabarriti, N Patrik Brodin, George Lundgren, Nitin Ohri, Wolfgang A Tomé, Shalom Kalnicki, Madhur K Garg
PURPOSE: To evaluate whether a response assessment using mid-treatment computed tomography (CT) scans during definitive radiation therapy (RT) for oropharyngeal head and neck cancer can predict for locoregional recurrence (LRR). METHODS AND MATERIALS: Head and neck cancer patients who receive RT at our institution undergo CT repeat scans at the 15th fraction, with treatment replanning in the case of an inadequate dose to gross disease or an increased dose to organs at risk...
April 6, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29774120/carboplatin-in-combination-with-weekly-paclitaxel-as-first-line-therapy-in-patients-with-recurrent-metastatic-head-and-neck-squamous-cell-carcinoma-unfit-to-extreme-schedule
#2
Adeline Pêtre, Cécile Dalban, Andy Karabajakian, Eve-Marie Neidhardt, Pierre Eric Roux, Marc Poupart, Sophie Deneuve, Philippe Zrounba, Jérome Fayette
The standard first-line treatment in recurrent/metastatic head and neck squamous cell carcinoma combines Cisplatin, 5 Fluorouracil and Cetuximab, but many patients aren't eligible. We retrospectively evaluated the efficacy and the tolerability of Carboplatin and Paclitaxel in this indication, mostly in patients unfit to Cisplatin. Paclitaxel (80mg/m2) was administered at day 1, 8 and 15 and Carboplatin area under the curve 5 at day 1, repeated every 28 days, for 6 cycles. Carboplatin could be administered at area under the curve 2 at day 1, 8 and 15...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29771090/-the-role-of-%C3%A2-%C3%A2-f-fdg-pet-ct-for-detecting-nodal-metastases-in-cn0-head-neck-cancer-patients%C3%AF-a-meta-analysis
#3
X Y Li, C L Sun, X D Du
Objective: The aim of this study is to evaluate the accuracy of ¹⁸F-fluorodeoxyglucose PET/CT(¹⁸F-FDG PET/CT) for the diagnosis of cervical node metastases in cN0 head neck cancer patients. Method: An electronic database search(PubMed,EMBASE,Cochrane Library,WanFang and CNKI databases)was performed. Updated quality assessment of diagnostic accuracy studies-2(QUADAS-2) was used to assess study quality. Data analyses were performed with Meta-Disc1.4. Result: Eight studies were included in the present Meta-analysis...
May 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29766142/improving-life-expectancy-a-broken-neck-doesn-t-have-to-be-a-terminal-diagnosis-for-the-elderly
#4
Laura N Godat, Leslie M Kobayashi, David C Chang, Raul Coimbra
Background: Elderly patients with cervical spine fractures require optimal care. Treatment with a cervical collar or halo instead of surgical fixation may increase mortality. This investigation intends to describe the life expectancy after injury and evaluate the impact of surgical intervention on mortality. Methods: Patients ≥65 years, with traumatic cervical spine fractures without cord injury were identified in the 1995-2009 California Office of Statewide Health and Planning database...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29764382/utility-of-routine-ultrasonography-follow-up-after-total-thyroidectomy-in-patients-with-papillary-thyroid-carcinoma-a-single-center-study
#5
Ha Kyoung Park, Dong Wook Kim, Tae Kwun Ha, Young Jin Heo, Jin Wook Baek, Yoo Jin Lee, Young Jun Cho, Dong Kun Lee, Do Hun Kim, Soo Jin Jung, Ki Jung Ahn, Hye Shin Ahn, Hye Jin Baek
BACKGROUND: This study aimed to assess the appropriate number of sessions and interval of routine follow-up ultrasonography (US) in patients who underwent total thyroidectomy for papillary thyroid carcinoma (PTC). METHODS: Between January 2008 and December 2009, 569 patients underwent total thyroidectomy for PTC. Of the 569 patients, 44 were excluded from the study because of no US follow-up data for the neck (n = 43) or owing to indeterminate tumor recurrence/persistence (n = 1)...
May 15, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#6
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29754496/detection-of-loco-regional-recurrence-in-malignant-head-and-neck-tumors-a-comparison-of-ct-mri-and-fdg-pet-ct
#7
Eun Soo Kim, Dae Young Yoon, Ji Yoon Moon, Sora Baek, You Mie Han, Young Lan Seo, Eun Joo Yun
Background The early and accurate detection of local or regional recurrence of head and neck tumor is critically important. Purpose To compare the diagnostic accuracy of contrast-enhanced computed tomography (CT), contrast-enhanced magnetic resonance imaging (MRI), and fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT, alone and in combination, in detecting the locoregional recurrence of malignant head and neck tumor. Material and Methods A total of 93 patients with loco-regional recurrence of malignant head and neck tumors underwent CT, MRI, and PET-CT within 30 days before surgery...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29754393/predicting-stress-urinary-incontinence-during-pregnancy-combination-of-pelvic-floor-ultrasound-parameters-and-clinical-factors
#8
Ling Chen, Dan Luo, Xiajuan Yu, Mei Jin, Wenzhi Cai
INTRODUCTION: The aim of this study was to develop and validate a predictive tool that combining pelvic floor ultrasound parameters and clinical factors for stress urinary incontinence during pregnancy. MATERIAL AND METHODS: A total of 535 women in first or second trimester were included for an interview and transperineal ultrasound assessment from two hospitals. Imaging data sets were analyzed offline to assess for bladder neck vertical position, urethra angles (α, β, and γ angles), hiatal area and bladder neck funneling...
May 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29753955/the-diagnostic-value-of-one-step-nucleic-acid-amplification-osna-in-differentiating-lymph-node-metastasis-of-tumors-a-systematic-review-and-meta-analysis
#9
REVIEW
Min Zhou, Xuzhen Wang, Liping Jiang, Xu Chen, Xin Bao, Xiang Chen
BACKGROUND: The aim of this study was clarify the diagnostic accuracy of one step nucleic acid amplification (OSNA) for differentiating metastatic lymph nodes from non-metastatic ones in patients with tumors (not including breast cancer). METHODS: A systematic literature search for original diagnostic studies was performed in PubMed. Findings were pooled by using combined effect models and hierarchic summary receiver operating characteristic curve models. Meta-regression analysis and threshold effect evaluating were performed to explore the sources of heterogeneity affected classification accuracy...
May 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29749361/risk-factors-for-ruptured-intracranial-aneurysms
#10
Guang-Xian Wang, Dong Zhang, Zhi-Ping Wang, Liu-Qing Yang, Hua Yang, Wen Li
Background & objectives: The treatment of unruptured intracranial aneurysms (IAs) remains controversial; the ability to predict the risk of rupture for an aneurysm would be of clinical value. The aim of this study was to determine and evaluate the predictive value of the risk factors of IA rupture. Methods: This retrospective study involved 379 consecutive patients with 441 aneurysms between August 2011 and July 2014. Based on clinical data and computed tomography angiography findings, the potential of risk factors to predict the aneurysmal rupture was assessed using statistical methods...
January 2018: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29748069/sensitivity-and-specificity-of-metal-ion-level-in-predicting-adverse-local-tissue-reactions-due-to-head-neck-taper-corrosion-in-primary-metal-on-polyethylene-total-hip-arthroplasty
#11
Young-Min Kwon, John MacAuliffe, Paul G Arauz, Yun Peng
BACKGROUND: There is increasing concern regarding the occurrence of adverse local tissue reactions (ALTRs) in metal-on-polyethylene (MoP) total hip arthroplasty (THA) patients due to mechanically assisted crevice corrosion at the head-neck modular taper junction. The utility of metal ion levels in evaluating MoP patients with head-neck taper has not been fully characterized. This study aimed to investigate the sensitivity and specificity of serum metal ions as a predictor of ALTR in MoP THA patients...
April 16, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29746570/opportunistic-osteoporosis-screening-via-the-measurement-of-frontal-skull-hounsfield-units-derived-from-brain-computed-tomography-images
#12
Min Kyun Na, Yu Deok Won, Choong Hyun Kim, Jae Min Kim, Jin Hwan Cheong, Je Il Ryu, Myung-Hoon Han
BACKGROUND AND PURPOSE: Osteoporosis is one of the most common chronic metabolic diseases, but detection and treatment rates are low. The aim of the current study was to evaluate the correlation between frontal skull Hounsfield unit (HU) values from brain computed tomography (CT) scans and T-scores of the lumbar spine and femoral neck from dual-energy X-ray absorptiometry (DXA) scans. METHODS: Patients with < 1 year between brain CT and DXA scans were included in the study...
2018: PloS One
https://www.readbyqxmd.com/read/29746178/head-and-neck-squamous-cell-carcinoma-in-adolescents-and-young-adults-survivorship-patterns-and-disparities
#13
Sai D Challapalli, Matthew C Simpson, Eric Adjei Boakye, Jay S Pannu, Dary J Costa, Nosayaba Osazuwa-Peters
PURPOSE: Adolescent and young adult (AYA) head and neck cancer (HNC) patients require longer term follow-ups as they age; yet, little is known about factors associated with survivorship in this population. We aimed to describe nonclinical factors associated with HNC survivorship among AYAs. METHODS: In this retrospective cohort study, the Surveillance, Epidemiology and End Results 18 database from 2007 to 2014 was queried. Eligible cases were 15-39-year-old primary HNC patients with known cause of death (n = 1777)...
May 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29745800/interaction-between-graviception-and-carotid-baroreflex-function-in-humans-during-parabolic-flight-induced-microgravity
#14
Shigehiko Ogoh, Michaël Marais, Romain Lericollais, Pierre Denise, Peter B Raven, Hervé Normand
The aim of the present study was to assess carotid baroreflex (CBR) during acute changes in otolithic activity in humans. To address this question, we designed a set of experiments to identify the modulatory effects of microgravity on CBR function at a tilt angle of -2{degree sign}, which was identified to minimize changes in central blood volume during parabolic flight. During parabolic flight at 0g and 1g, CBR function curves were modelled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulse trains of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr; CBR control of HR (carotid-HR) and MAP (carotid-MAP) baroreflex function curves, respectively...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29743732/magnetic-resonance-imaging-dynamic-contrast-enhancement-and-diffusion-weighted-imaging-to-identify-malignant-cervical-lymph-nodes
#15
Murilo Bicudo Cintra, Hilton Ricz, Mahmood F Mafee, Antonio Carlos Dos Santos
Objective: To examine the potential of two magnetic resonance imaging (MRI) techniques-dynamic contrast enhancement (DCE) and diffusion-weighted imaging (DWI)-for the detection of malignant cervical lymph nodes. Materials and Methods: Using DCE and DWI, we evaluated 33 cervical lymph nodes. For the DCE technique, the maximum relative enhancement, relative enhancement, time to peak enhancement, wash-in rate, wash-out rate, brevity of enhancement, and area under the curve were calculated from a semi-quantitative analysis...
March 2018: Radiologia Brasileira
https://www.readbyqxmd.com/read/29743392/a-health-behavior-screening-tool-for-non-specific-neck-pain-in-office-workers-a-1-year-prospective-cohort-study
#16
Kantheera Areerak, Allard J van der Beek, Prawit Janwantanakul
OBJECTIVE: One effective strategy for management of musculoskeletal disorders is self-management based on the biopsychosocial model. Self-management requires patients to have adequate health literacy, defined as the individual's ability to seek, understand, and utilize health information. Recently, the neck pain-specific health behavior for office workers (NHBOW) questionnaire was developed based upon a conceptual framework of health literacy. The content in the NHBOW relates to the work and exercise behaviors of office workers...
May 9, 2018: Journal of Occupational Health
https://www.readbyqxmd.com/read/29741773/phase-2-trial-of-neoadjuvant-chemotherapy-and-transoral-endoscopic-surgery-with-risk-adapted-adjuvant-therapy-for-squamous-cell-carcinoma-of-the-head-and-neck
#17
Jared M Weiss, Juneko E Grilley-Olson, Allison Mary Deal, Jose P Zevallos, Bhishamjit S Chera, Jennifer Paul, Mary Fleming Knowles, Dmitriy Usenko, Mark C Weissler, Samip Patel, David N Hayes, Trevor Hackman
BACKGROUND: The objective of this study was to demonstrate the feasibility and efficacy of induction chemotherapy, surgery, and pathology-guided adjuvant therapy to treat transorally resectable squamous head and neck cancer. METHODS: Patients had squamous head and neck cancer that was resectable by the transoral route and advanced-stage disease (American Joint Committee on Cancer stage III-IV, T3-T4 tumors, and/or positive lymph nodes). They received treatment with weekly carboplatin at an area under the curve of 2, plus paclitaxel 135 mg/m2 , and daily lapatinib 1000mg for 6 weeks followed by surgical resection...
May 9, 2018: Cancer
https://www.readbyqxmd.com/read/29740660/differentiation-between-malignant-and-benign-musculoskeletal-tumors-using-diffusion-kurtosis-imaging
#18
Masaki Ogawa, Hirohito Kan, Nobuyuki Arai, Taro Murai, Yoshihiko Manabe, Yusuke Sawada, Yuta Shibamoto
OBJECTIVE: The purpose of this study was to evaluate differences in parameters of diffusion kurtosis imaging (DKI) and minimum apparent diffusion coefficient (ADCmin ) between benign and malignant musculoskeletal tumors. MATERIALS AND METHODS: In this prospective study, 43 patients were scanned using a DKI protocol on a 3-T MR scanner. Eligibility criteria were: non-fatty, non-cystic soft tissue or osteolytic tumors; > 2 cm; location in the retroperitoneum, pelvis, leg, or neck; and no prior treatment...
May 9, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29739732/inherited-deletion-of-1q-hyperparathyroidism-and-signs-of-y-chromosomal-influence-in-a-patient-with-turner-syndrome
#19
Alejandro F Siller, Alex Shimony, Marwan Shinawi, Ina Amarillo, Louis P Dehner, Katherine Semenkovich, Ana María Arbeláez
We report a detailed phenotypic, cytogenetic, and molecular characterization of a patient diagnosed prenatally with Turner syndrome (TS). In addition to having typical TS clinical characteristics such as a webbed neck, high arched palate, and coarctation of the aorta, the patient had features less frequently seen in TS, including recurrent parathyroid adenomas, growth along the 75th-90th centiles on the TS height curve despite a minimal treatment with growth hormone, behavioral problems, and evidence of gonadal dysgenesis with testicular-like structures, such as seminiferous tubules lined by Sertoli cells and a contiguous nodule of Leydig cells...
May 9, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29736726/high-incidence-of-intraoperative-calcar-fractures-with-the-cementless-cls-spotorno-stem
#20
Carla Timmer, Davey M J M Gerhardt, Enrico de Visser, Marinus de Kleuver, Job L C van Susante
INTRODUCTION: This study reports on the incidence of intraoperative calcar fractures with the cementless Spotorno (CLS) stem, and the potential role of a learning curve and implant positioning is investigated. METHODS: After introduction of the CLS stem, 800 consecutive cementless total hip arthroplasties (THA) were analyzed. The incidence of calcar fracture in the first 400 THA was compared with the second 400 THA, in order to study a potential learning curve effect...
May 7, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
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