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https://www.readbyqxmd.com/read/28340596/clinical-treatment-considerations-in-the-intensity-modulated-radiotherapy-era-for-patients-with-n0-category-nasopharyngeal-carcinoma-and-enlarged-neck-lymph-nodes
#1
Hao Peng, Lei Chen, Rui Guo, Yuan Zhang, Wen-Fei Li, Yan-Ping Mao, Ying Sun, Fan Zhang, Li-Zhi Liu, Li Tian, Jun Ma
BACKGROUND: Nasopharyngeal carcinoma (NPC) shows a high proportion of lymph node metastasis, and treatment guidelines have been developed for positive nodes. However, no irradiation guidelines have been proposed for patients with enlarged neck lymph nodes (ENLNs) that do not meet the radiological criteria of 10 mm in diameter for positive lymph nodes. This study aimed to determine the prognostic value and radiation dose for ENLNs in N0-category NPC patients treated with intensity-modulated radiotherapy (IMRT)...
March 24, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28304190/the-second-generation-eclips-endovascular-clip-system-initial-experience
#2
Albert H Chiu, Joost De Vries, Cian J O'Kelly, Howard Riina, Ian McDougall, Jonathan Tippett, Martina Wan, Airton Leonardo de Oliveira Manoel, Thomas R Marotta
OBJECTIVE Treatment of wide-necked intracranial aneurysms is associated with higher recanalization and complication rates; however, the most commonly used methods are not specifically designed to work in bifurcation lesions. To address these issues, the authors describe the evolution in the design and use of the eCLIPs (Endovascular Clip System) device, a novel hybrid stent-like assist device with flow diverter properties that was first described in 2008. METHODS A registry was established covering 13 international centers at which patients were treated with the second-generation eCLIPs device...
March 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28304123/incidental-parathyroidectomy-during-total-thyroidectomy-is-not-a-direct-cause-of-post-operative-hypocalcaemia
#3
Carolyn Chew, Ran Li, Michael K Ng, Steven T F Chan, Bill Fleming
BACKGROUND: Post-operative hypocalcaemia is the most common complication after total thyroidectomy, with a reported incidence of transient hypocalcaemia up to 50% and permanent hypocalcaemia 1.5-4%. The impact of incidental parathyroidectomy (IPE) on post-operative hypocalcaemia remains controversial. This study evaluated the risk factors for IPE following total thyroidectomy and compared post-operative calcium levels serially between patients with and without IPE. METHODS: A retrospective analysis of patients undergoing total thyroidectomy from January 2009 to October 2016 at Western Health was conducted...
March 17, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28303130/new-approaches-on-quantification-of-campylobacter-jejuni-in-poultry-samples-the-use-of-digital-pcr-and-real-time-pcr-against-the-iso-standard-plate-count-method
#4
Bojan Papić, Mateja Pate, Urška Henigman, Urška Zajc, Igor Gruntar, Majda Biasizzo, Matjaž Ocepek, Darja Kušar
Campylobacteriosis is the most frequently reported bacterial food-borne illness in the European Union and contaminated broiler meat is considered the most important source of infection in humans. The aim of the present study was to evaluate real-time PCR (qPCR) and digital PCR (dPCR) for quantification of Campylobacter jejuni in 75 broiler neck-skin samples collected from a poultry slaughterhouse, and to compare them with the ISO 10272-2 standard plate count method. For qPCR standard curve, C. jejuni-negative neck-skin samples were spiked with C...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28291404/outcomes-and-effectiveness-of-posterior-occipitocervical-fusion-for-suboccipital-spinal-metastases
#5
Panya Luksanapruksa, Jacob M Buchowski, Neill M Wright, Frank H Valone, Colleen Peters, David B Bumpass
OBJECTIVE The incidence of suboccipital spinal metastases is rare but has increased given cancer patients' longer life expectancies. Operative treatment in this region is often challenging because of limited fixation points due to tumor lysis, as well as adjacent neural and vascular anatomy. Few studies have reported on this population of cancer patients. The purpose of this study was to evaluate clinical outcomes and complications of patients with suboccipital spinal metastases who had undergone posterior occipitocervical fixation...
February 24, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28289955/atomistic-simulation-study-of-tensile-deformation-in-nanocrystalline-and-single-crystal-au
#6
Cheng-Da Wu, Hsing-Wei Tsai
The effect of notch size (r) on nanocrystalline (NC) and single-crystal (SC) Au at a temperature of 300 K under tension testing is studied using molecular dynamics simulations based on the many-body embedded-atom potential. The effect is investigated in terms of atomic trajectories, common neighbor analysis, and the stress-strain curve. The simulation results show that for the NC samples, stacking faults nucleate at grain boundaries (GBs), propagate inside grains, and eventually are terminated by GBs or transect them...
April 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28289664/significance-of-micrometastases-in-the-calculation-of-the-lymph-node-ratio-for-papillary-thyroid-cancer
#7
Young Woo Chang, Hwan Soo Kim, Seung Pil Jung, Hoon Yub Kim, Jae Bok Lee, Jeoung Won Bae, Gil Soo Son
PURPOSE: The lymph node ratio (LNR) is an important prognostic factor in papillary thyroid carcinoma (PTC), but micrometastases in cervical lymph nodes (LNs) are not of great clinical importance. In this study, we analyzed the accuracy of prediction of the prognosis depending on whether micrometastases were included in the number of metastatic LNs when calculating LNR. METHODS: The study included 353 PTC patients who underwent total thyroidectomy with neck LN dissection, and calculated LNR by 2 methods according to whether micrometastases were included in the number of metastatic LNs: Method 1 did not and method 2 did include...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28286397/perforator-peroneal-artery-flap-for-tongue-reconstruction
#8
Shubhra Chauhan, Sachin Chavre, Naveen Hedne Chandrashekar, Naveen B S
INTRODUCTION: Reconstruction has evolved long way from primary closure to flaps. As time evolved, better understanding of vascularity of flap has led to the development of innovative reconstructive techniques. These flaps can be raised from various parts of the body for reconstruction and have shown least donor site morbidity. We use one such peroneal artery perforator flap for tongue reconstruction with advantage of thin pliable flap, minimal donor site morbidity and hidden scar. MATERIALS AND METHODS: Our patient 57yrs old lady underwent wide local excision with selective neck dissection...
March 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28280363/discrimination-of-serous-cystadenoma-from-mucinous-cystadenoma-in-the-pancreas-with-contrast-enhanced-ultrasonography-a-prospective-study-in-61-patients
#9
Ya Sun, Fubo Zhou, Fangyi Liu, Yanyan Hu, Shuilian Tan, Ping Liang, Enqiang Linghu, Xiaoling Yu
OBJECTIVES: The preoperative diagnosis between serous cystadenomas (SCAs) and mucinous cystadenomas (MCAs) in pancreas is significant due to their completely different biological behaviors. The purpose of our study was to examine and compare detailed contrast-enhanced ultrasonography (CEUS) images of SCAs and MCAs and to determine whether there are significant findings that can contribute to the discrimination between these two diseases. METHODS: From April 2015 to June 2016, 61 patients (35 patients with SCAs and 26 patients with MCAs) were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28278337/a-proposal-to-redefine-close-surgical-margins-in-squamous-cell-carcinoma-of-the-oral-tongue
#10
Daniella Karassawa Zanoni, Jocelyn C Migliacci, Bin Xu, Nora Katabi, Pablo H Montero, Ian Ganly, Jatin P Shah, Richard J Wong, Ronald A Ghossein, Snehal G Patel
Importance: Resection of the primary tumor with negative margins is the gold standard treatment for squamous cell carcinoma of the oral tongue (SCCOT). A microscopically positive surgical margin is clearly associated with a higher risk for local recurrence, whereas a negative margin has traditionally been defined as greater than 5.0 mm clearance from the tumor, with lesser margins arbitrarily designated as close. The precise cutoff at which the risk for local recurrence with a close margin approximates that of a microscopically positive margin remains unclear...
March 9, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28277592/evaluation-of-the-effects-of-the-metha-short-stem-on-periprosthetic-bone-remodelling-in-total-hip-arthroplasties-results-at-48-months
#11
Paolo D Parchi, Gianluca Ciapini, Iacopo Castellini, Claudia Mannucci, Anna Maria Nucci, Nicola Piolanti, Silvia Maffei, Michele Lisanti
INTRODUCTION: Total hip arthroplasty is one of the most performed procedures in orthopaedic surgery. Implantation of a prosthesis determines changes in the distribution of loads on the host bone, and this phenomenon, known as stress shielding, is related to the biomechanical characteristics of the implant. Usually stress shielding involves the proximal portion of the femur by reducing the mechanical strength and ability to withstand the transmitted loads. The aim of our study is to demonstrate how the use of a short hip stem reduces the stress shielding phenomenon to the proximal femur...
March 9, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/28271529/definitive-chemoradiotherapy-with-carboplatin-for-squamous-cell-carcinoma-of-the-head-and-neck
#12
Misako Nagasaka, Mark Zaki, Majd Issa, Harold Kim, Judith Abrams, Ammar Sukari
OBJECTIVE: Definitive concurrent chemoradiotherapy (CRT) is considered the standard of care for organ preservation and is the only potentially curative therapy for surgically unresectable patients with stage III to IVb locally advanced squamous cell carcinoma of the head and neck. In patients with high risks for adverse events utilizing cisplatin, carboplatin has been empirically substituted. The objective of this study was to estimate the locoregional control rate, progression-free survival, overall survival, and adverse events in locally advanced squamous cell carcinoma of the head and neck patients treated with CRT utilizing carboplatin...
March 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28269746/influences-of-osteoarthritis-and-osteoporosis-on-the-electrical-properties-of-human-bones-as-in-vivo-electrets-produced-due-to-wolff-s-law
#13
Kazuhiro Kohata, Soichiro Itoh, Naohiro Horiuchi, Taro Yoshioka, Kimihiro Yamashita
We characterized the electrical properties of living bone obtained from patients who had undergone total hip arthroplasty (THA) or hemiarthroplasty by means of analysis of the electrically polarized and nonpolarized bone specimens, and we discussed the role of an organic and inorganic matrix of human bone in bone piezoelectricity.We used human femoral neck bone that was harvested during THA for advanced osteoarthritis of the hip joint (OA group) and hemiarthroplasty for femoral neck fracture (FNF group). The specimens were scanned to evaluate the cancellous bone structures using micro-computed tomography, and we quantified the carbonic acid by attenuated total reflection (ATR) spectra to estimate carbonate apatite...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28258945/the-performance-of-neck-circumference-and-other-airway-assessment-tests-for-the-prediction-of-difficult-intubation-in-obese-parturients-undergoing-cesarean-delivery
#14
J Eiamcharoenwit, N Itthisompaiboon, P Limpawattana, A Suwanpratheep, A Siriussawakul
BACKGROUND: Pregnancy and obesity each increase the chance of difficult tracheal intubation. This study assessed the performance of the neck circumference and other bedside tests for predicting difficult intubation, and aimed to identify the optimal cutoff point of the test(s) with the highest performance. METHODS: Parturients with a body mass index ≥30kg/m(2), undergoing a cesarean delivery employing conventional tracheal intubation, were enrolled. Preoperative neck circumference, sternomental distance and modified Mallampati test were examined...
February 5, 2017: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/28255813/gene-promoter-associated-cpg-island-hypermethylation-in-squamous-cell-carcinoma-of-the-tongue
#15
Samatha Bhat, Shama Prasada Kabekkodu, Chinchu Jayaprakash, Raghu Radhakrishnan, Satadru Ray, Kapaettu Satyamoorthy
The present study was undertaken to explore and validate novel hypermethylated DNA regions in squamous cell carcinoma of the tongue (SCCT). Genome-wide methylation changes were identified by differential methylation hybridization (DMH) microarray and validated by bisulfite genome sequencing (BGS). The results were compared against datasets from The Cancer Genome Atlas head and neck squamous cell carcinoma (TCGA-HNSCC), Gene Expression Omnibus (GSE26549), and ArrayExpress (E-MTAB-1328). DMH identified 116 hypomethylated and 241 hypermethylated regions...
March 2, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28254673/cervical-lordosis-the-effect-of-age-and-gender
#16
Ella Been, Sara Shefi, Michalle Soudack
BACKGROUND CONTEXT: The cervical lordosis is of great importance to posture and function. Neck pain and disability is often associated with cervical lordosis malalignment. Surgical procedures involving cervical lordosis stabilization or restoration must take into account age and gender differences in cervical lordosis architecture, to avoid further complications. PURPOSE: Therefore, the purpose of this study was to evaluate differences in the cervical lordosis between males and females from childhood to adulthood...
February 27, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28254671/are-patient-reported-outcomes-predictive-of-patient-satisfaction-5-years-after-anterior-cervical-spine-surgery
#17
Gregory D Schroeder, Dom Coric, Han Jo Kim, Todd J Albert, Kris E Radcliff
BACKGROUND CONTEXT: Patient satisfaction is becoming an increasing common proxy for surgical quality; however, the correlation between patient satisfaction and surgical outcomes 2 and 5 years after anterior cervical surgery has not been evaluated. PURPOSE: The study aimed to determine if patient satisfaction is predicted by improvement in patient-reported outcomes (PRO) 2 and 5 years after anterior cervical spine surgery. STUDY DESIGN: This is a retrospective analysis of prospectively collected data...
February 27, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28253896/evaluation-of-singh-index-and-osteoporosis-self-assessment-tool-for-asians-as-risk-assessment-tools-of-hip-fracture-in-patients-with-type-2-diabetes-mellitus
#18
Zhenyu Liu, Hua Gao, Xiaodong Bai, Liang Zhao, Yadong Li, Baojun Wang
BACKGROUND: Type 2 diabetes mellitus (T2DM), an epidemic disease around world, has recently been identified as a risk factor for osteoporosis-associated fracture. However, there is no consensus on the best method of assessing fracture risk in patients with T2DM. The aim of this study was to evaluate the usefulness of the Osteoporosis Self-Assessment Tool for Asians (OSTA) and the Singh Index (SI) in hip fracture risk assessment in patients with T2DM. METHODS: We enrolled 261 postmenopausal women with T2DM: 87 had hip fracture resulting from low-energy trauma and 174 age-matched controls had no fracture (two controls per fracture case)...
March 3, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28243686/flow-diversion-what-can-clinicians-learn-from-animal-models
#19
Robert Fahed, Tim E Darsaut, Jean-Christophe Gentric, Behzad Farzin, Igor Salazkin, Guylaine Gevry, Jean Raymond
INTRODUCTION: Flow diversion is increasingly used for treating intracranial aneurysms. This article aims to review the evidence obtained from animal models and summarizes the findings that might be of clinical interest. METHODS: From a systematic review of studies published between 2000 and 2016, we extracted the data on the following questions: What roles do aneurysm dimension, morphology, and vascular geometry have on success of flow diversion? What characteristics of a flow diverter can influence aneurysm occlusion? What are the risk factors for jailed branch occlusion? RESULTS: Flow diversion has been shown to be less effective in occluding large aneurysms with wide or undefined necks, as compared to smaller aneurysms with narrower necks...
February 27, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28228129/prognostic-value-of-the-sliding-length-of-cephalocervical-screws-to-predict-the-risk-of-non-union-after-osteosynthesis-a-retrospective-analysis-of-86-patients-with-intracapsular-femoral-neck-fractures
#20
Yohei Hirakawa, Hidehiro Nakamura, Kazuhito Minamitani, Ryuki Hashida, Masafumi Gotoh, Naoto Shiba
BACKGROUND: Here, we assessed the prognostic value of the early sliding length (ESL) for predicting the risk of non-union after internal fixation of femoral neck fractures (FNFs) by Dual SC Screws (DSCS). METHODS: A retrospective analysis of 86 patients with intra-capsular FNFs was performed. They underwent osteosynthesis by DSCS at our institution between 2008 and 2013 with a minimum follow-up duration of 6 months. Preoperative displacement, fracture reduction quality, ESL of screws at 2 weeks postoperatively, and correlation of non-union with the ESL of screws were evaluated...
February 22, 2017: Journal of Orthopaedic Surgery and Research
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