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https://www.readbyqxmd.com/read/28627475/joint-specific-risk-of-impaired-function-in-fibrodysplasia-ossificans-progressiva-fop
#1
Robert J Pignolo, Blythe P Durbin-Johnson, David M Rocke, Frederick S Kaplan
BACKGROUND: Fibrodysplasia ossificans progressiva (FOP) causes progressive disability due to heterotopic ossification from episodic flare-ups. Using data from 500 FOP patients (representing 63% of all known patients world-wide), age- and joint-specific risks of new joint involvement were estimated using parametric and nonparametric statistical methods. RESULTS: Compared to data from a 1994 survey of 44 individuals with FOP, our current estimates of age- and joint-specific risks of new joint involvement are more accurate (narrower confidence limits), based on a wider range of ages, and have less bias due to its greater comprehensiveness (captures over three-fifths of the known FOP patients worldwide)...
June 13, 2017: Bone
https://www.readbyqxmd.com/read/28618147/feedback-preferences-of-patients-professionals-and-health-insurers-in-integrated-head-and-neck-cancer-care
#2
Lydia F J van Overveld, Robert P Takes, Thomas W Vijn, Jozé C C Braspenning, Jan P de Boer, John J A Brouns, Rolf J Bun, Boukje A C van Dijk, Judith A W F Dortmans, Emilie A C Dronkers, Robert J J van Es, Frank J P Hoebers, Arvid Kropveld, Johannes A Langendijk, Ton P M Langeveld, Sjoukje F Oosting, Hendrik P Verschuur, Jan G A M de Visscher, Stijn van Weert, Matthias A W Merkx, Ludi E Smeele, Rosella P M G Hermens
BACKGROUND: Audit and feedback on professional practice and health care outcomes are the most often used interventions to change behaviour of professionals and improve quality of health care. However, limited information is available regarding preferred feedback for patients, professionals and health insurers. OBJECTIVE: Investigate the (differences in) preferences of receiving feedback between stakeholders, using the Dutch Head and Neck Audit as an example. METHODS: A total of 37 patients, medical specialists, allied health professionals and health insurers were interviewed using semi-structured interviews...
June 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28616099/epigenetic-silencing-of-sall3-is-an-independent-predictor-of-poor-survival-in-head-and-neck-cancer
#3
Kiyoshi Misawa, Daiki Mochizuki, Atsushi Imai, Yuki Misawa, Shiori Endo, Masato Mima, Hideya Kawasaki, Thomas E Carey, Takeharu Kanazawa
BACKGROUND: This study examined Sal-like protein (SALL)3 methylation profiles of head and neck cancer (HNSCC) patients at diagnosis and follow-up and evaluated their prognostic significance and value as a biomarker. SALL3 expression was examined in a panel of cell lines by quantitative reverse transcription polymerase chain reaction (RT-PCR). The methylation status of the SALL3 promoter was examined by quantitative methylation-specific PCR. RESULTS: SALL3 promoter methylation was associated with transcriptional inhibition and was correlated with disease recurrence in 64...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28611887/derivation-and-validation-of-the-prehospital-difficult-airway-identificationtool-predait-a-predictive-model-for-difficult-intubation
#4
Jestin N Carlson, David Hostler, Francis X Guyette, Mark Pinchalk, Christian Martin-Gill
INTRODUCTION: Endotracheal intubation (ETI) in the prehospital setting poses unique challenges where multiple ETI attempts are associated with adverse patient outcomes. Early identification of difficult ETI cases will allow providers to tailor airway-management efforts to minimize complications associated with ETI. We sought to derive and validate a prehospital difficult airway identification tool based on predictors of difficult ETI in other settings. METHODS: We prospectively collected patient and airway data on all airway attempts from 16 Advanced Life Support (ALS) ground emergency medical services (EMS) agencies from January 2011 to October 2014...
June 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28611305/kdm4a-as-a-prognostic-marker-of-oral-squamous-cell-carcinoma-evidence-from-tissue-microarray-studies-in-a-multicenter-cohort
#5
Xin Jin, Hao Xu, Xingyu Wu, Taiwen Li, Jing Li, Yu Zhou, Hongxia Dan, Lu Jiang, Xin Zeng, Ping Ji, Qianming Chen
PURPOSE: Previous studies have identified histone demethylase KDM4A to be a key epigenetic priming factor for the invasive squamous cell carcinoma growth and metastasis. The purpose of this study was to examine KDM4A as an independent prognostic marker in oral squamous cell carcinoma, using multicenter tissue microarrays. RESULTS: The expression of KDM4A was significantly correlated with lymph node metastasis and TNM stage. KDM4A overexpression was associated with poor overall survival, and it was found to be a statistically significant independent predictor of all-cause mortality...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28601565/gait-analysis-of-young-male-patients-diagnosed-with-primary-bladder-neck-obstruction
#6
Matteo Zago, Tommaso Ciro Camerota, Stefano Pisu, Daniela Ciprandi, Chiarella Sforza
Primary bladder neck obstruction (PBNO) represents an inappropriate or inadequate relaxation of the bladder neck during micturition. Based on the observation of an increased rate of postural imbalances in male patients with PBNO, we hypothesized a possible role of an unbalanced biomechanics of the pelvis on urethral sphincters activity. Our aim was to identify kinematic imbalances, usually disregarded in PBNO patients, and which could eventually be involved in the etiopathogenesis of the disease. Seven male adult patients (39...
June 2, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28589853/n-of-1-pathways-mixenrich-advancing-precision-medicine-via-single-subject-analysis-in-discovering-dynamic-changes-of-transcriptomes
#7
Qike Li, A Grant Schissler, Vincent Gardeux, Ikbel Achour, Colleen Kenost, Joanne Berghout, Haiquan Li, Hao Helen Zhang, Yves A Lussier
BACKGROUND: Transcriptome analytic tools are commonly used across patient cohorts to develop drugs and predict clinical outcomes. However, as precision medicine pursues more accurate and individualized treatment decisions, these methods are not designed to address single-patient transcriptome analyses. We previously developed and validated the N-of-1-pathways framework using two methods, Wilcoxon and Mahalanobis Distance (MD), for personal transcriptome analysis derived from a pair of samples of a single patient...
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28583628/lymph-node-metastasis-in-head-and-neck-squamous-carcinoma-efficacy-of-intravoxel-incoherent-motion-magnetic-resonance-imaging-for-the-differential-diagnosis
#8
Long Liang, Xiaoning Luo, Zhouyang Lian, Wenbo Chen, Bin Zhang, Yuhao Dong, Changhong Liang, Shuixing Zhang
PURPOSE: To evaluate the value of pure molecular diffusion(D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory for differential diagnosis of metastatic lymph nodes (LNs) in head and neck squamous cell carcinoma(HNSCC). MATERIALS AND METHODS: 29 patients with HNSCC and 20 patients with lymph node hyperplasia (LNH) were enrolled in this retrospective study, underwent magnetic resonance (MR) examination...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28583625/residual-tumour-detection-in-post-treatment-granulation-tissue-by-using-advanced-diffusion-models-in-head-and-neck-squamous-cell-carcinoma-patients
#9
Noriyuki Fujima, Daisuke Yoshida, Tomohiro Sakashita, Akihiro Homma, Kohsuke Kudo, Hiroki Shirato
PURPOSE: To evaluate the detectability of the residual tumour in post-treatment granulation tissue using parameters obtained with an advanced diffusion model in patients with head and neck squamous cell carcinoma (HNSCC) treated by chemoradiation therapy. MATERIALS AND METHODS: We retrospectively evaluated 23 patients with HNSCC after the full course of chemoradiation therapy. The diffusion-weighted image (DWI) acquisition used single-shot spin-echo echo-planar imaging with 11 b-values (0-1000)...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28580710/a-nomogram-for-predicting-the-risk-of-neck-node-metastasis-in-pathologically-node-negative-oral-cavity-carcinoma
#10
Sharada Sawant, Harsh Dongre, Chetan Ahire, Shilpi Sharma, Sadhana Kannan, Snehal Mahadik, Devendra Chaukar, Fatima Lukmani, Asawari Patil, Anil D'Cruz, Milind Vaidya, Prabhakar Dongre
OBJECTIVE: To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS: Surgically removed oral tumours (n=103) were analyzed for the expression of desmosomal and hemidesmosomal assembly proteins by immunohistochemistry and ultrastructural alterations by transmission electron microscopy (TEM)...
June 5, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28580200/treatment-outcomes-of-rare-retromolar-trigone-squamous-cell-carcinoma-using-combined-modalities
#11
Muhammad Faisal, Taskheer Abbas, Usman Khaleeq, Mohammad Adeel, Abdul Wahid Anwer, Raza Hussain, Arif Jamshed
BACKGROUND: Retromolar trigone squamous cell carcinoma is relatively uncommon and due to its complex anatomy has always remained a challenge in terms of loco-regional control and survival. Surgery, radiotherapy, and chemotherapy as combined modalities have been used but high recurrence rates result in poor outcome. METHODS: We have retrospectively evaluated records of 62 patients treated in Head and Neck Oncology unit of Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan from 2004 to 2014 who were included based on the criteria of histopathological proven squamous cell carcinoma of retromolar trigone (RMT) treated with radical intent...
May 1, 2017: Curēus
https://www.readbyqxmd.com/read/28577552/determining-the-amount-of-training-needed-for-competency-of-anesthesia-trainees-in-ultrasonographic-identification-of-the-cricothyroid-membrane
#12
Katia F Oliveira, Cristian Arzola, Xiang Y Ye, Jefferson Clivatti, Naveed Siddiqui, Kong E You-Ten
BACKGROUND: Airway guidelines recommend the use of ultrasound to localize the cricothyroid membrane prior to airway manipulation in difficult airways. In this study, we aimed to determine the amount of training anesthesia trainees would need to achieve competence in bedside ultrasound to identify the cricothyroid membrane. METHODS: This is a prospective non-randomized cohort study in the Department of Anesthesia at Mount Sinai Hospital (Toronto, Ontario, Canada)...
June 2, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28564716/clinical-utility-of-a-functional-lumen-imaging-probe-in-management-of-dysphagia-following-head-and-neck-cancer-therapies
#13
Peter I Wu, Michal M Szczesniak, Julia Maclean, Lennart Choo, Harry Quon, Peter H Graham, Teng Zhang, Ian J Cook
Background and aims Chemoradiotherapy for head and neck cancer (HNC) with/without laryngectomy commonly causes dysphagia. Pharyngoesophageal junction (PEJ) stricturing is an important contributor. We aimed to validate a functional lumen imaging probe (the EndoFLIP system) as a tool for quantitating pretreatment PEJ distensibility and treatment-related changes in HNC survivors with dysphagia and to evaluate the diagnostic accuracy of EndoFLIP-derived distensibility in detecting PEJ strictures. Methods We studied 34 consecutive HNC survivors with long-term (> 12 months) dysphagia who underwent endoscopic dilation for suspected strictures...
May 31, 2017: Endoscopy
https://www.readbyqxmd.com/read/28561274/statistical-shape-modelling-of-hip-and-lumbar-spine-morphology-and-their-relationship-in-the-mrc-national-survey-of-health-and-development
#14
Anastasia V Pavlova, Fiona R Saunders, Stella G Muthuri, Jennifer S Gregory, Rebecca J Barr, Kathryn R Martin, Rebecca J Hardy, Rachel Cooper, Judith E Adams, Diana Kuh, Richard M Aspden
The anatomical shape of bones and joints is important for their proper function but quantifying this, and detecting pathological variations, is difficult to do. Numerical descriptions would also enable correlations between joint shapes to be explored. Statistical shape modelling (SSM) is a method of image analysis employing pattern recognition statistics to describe and quantify such shapes from images; it uses principal components analysis to generate modes of variation describing each image in terms of a set of numerical scores after removing global size variation...
May 31, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28560474/vertebral-fracture-in-postmenopausal-chinese-women-a-population-based-study
#15
L Cui, L Chen, W Xia, Y Jiang, L Cui, W Huang, W Wang, X Wang, Y Pei, X Zheng, Q Wang, Z Ning, M Li, O Wang, X Xing, Q Lin, W Yu, X Weng, L Xu, S R Cummings
In a random sample of postmenopausal Chinese women, the prevalence of radiographic vertebral fractures increased from 13% between ages 50 and 59 to over 50% after age 80 years. A model with seven clinical risk factors predicted the probability of vertebral fractures as well with as without BMD and better than a model with only three risk factors. More than half an hour of outdoor activity per day might correlate with lower risk of vertebral fracture in this population. INTRODUCTION: We aimed to describe the prevalence and develop a model for prediction of radiographic vertebral fractures in a large random sample of postmenopausal Chinese women...
May 30, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28559018/outcome-of-recurrent-and-metastatic-head-and-neck-squamous-cell-cancer-patients-after-first-line-platinum-and-cetuximab-therapy
#16
Marco Siano, Gabriele Infante, Carlo Resteghini, Maria Chiara Cau, Salvatore Alfieri, Cristiana Bergamini, Roberta Granata, Rosalba Miceli, Laura Locati, Lisa Licitra, Paolo Bossi
OBJECTIVES: Second-line chemotherapy in recurrent and/or metastatic head and neck cancer (r/mHNSCC) patients showed dismal results with limited tumor response and reduced life expectancy. Outside of clinical trials, data on efficacy of second line treatment after first line anti-EGFR-AB combination therapy are not available. MATERIAL AND METHODS: Data regarding r/mHNSCC consecutive pts treated with cetuximab and platinum from 2009 to 2014 at our center were retrospectively collected...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28559015/hla-traits-linked-to-development-of-head-and-neck-squamous-cell-carcinoma-affect-the-progression-free-survival-of-patients
#17
Gunnar Wichmann, Cindy Herchenhahn, Andreas Boehm, Christian Mozet, Mathias Hofer, Milos Fischer, Marlen Kolb, Andreas Dietz
BACKGROUND: Personalized medicine and treatment stratification of patients with head and neck squamous cell carcinoma (HNSCC) today mostly ignore genetic heterogeneity in HNSCC but especially the patient's genetic background. We hypothesized that particular human leukocyte antigen (HLA) class I (HLA-A, B, Cw) and II proteins (DR, DQ) confer susceptibility for and influence development of HNSCC and may be prognostic factors for progression-free survival (PFS). METHODS: 90 consecutive HNSCC patients of the prospective observational cohort study LIFE treated between 08/2010 and 05/2011 at the University Leipzig underwent low resolution typing of HLA-A, B, Cw, DR, and DQ...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28557582/surgeon-performance-predicts-early-continence-after-robotic-assisted-radical-prostatectomy
#18
Mitchell G Goldenberg, S Larry Goldenberg, Teodor P Grantcharov
INTRODUCTION: There is limited, yet compelling evidence supporting the role of surgeon technical skill in influencing patient outcomes. To date, this concept has been underexplored in urologic surgery. We hypothesized that a surgeon's technical performance plays a role in predicting an early return to continence after robotic-assisted radical prostatectomy (RARP). METHODS: We conducted a retrospective, matched case-control analysis of prospectively collected unedited RARP endoscopic videos performed by a single surgeon...
May 30, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28551764/autofluorescence-spectroscopy-for-nerve-sparing-laser-surgery-of-the-head-and-neck-the-influence-of-laser-tissue-interaction
#19
Florian Stelzle, Maximilian Rohde, Max Riemann, Nicolai Oetter, Werner Adler, Katja Tangermann-Gerk, Michael Schmidt, Christian Knipfer
The use of remote optical feedback systems represents a promising approach for minimally invasive, nerve-sparing laser surgery. Autofluorescence properties can be exploited for a fast, robust identification of nervous tissue. With regard to the crucial step towards clinical application, the impact of laser ablation on optical properties in the vicinity of structures of the head and neck has not been investigated up to now. We acquired 24,298 autofluorescence spectra from 135 tissue samples (nine ex vivo tissue types from 15 bisected pig heads) both before and after ER:YAG laser ablation...
May 27, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28540535/prognostic-value-of-maximum-standardized-uptake-value-measured-by-pretreatment-18f-fdg-pet-ct-in-locally-advanced-head-and-neck-squamous-cell-carcinoma
#20
J Cacicedo, I Fernandez, O Del Hoyo, A Navarro, A Gomez-Iturriaga, J Ignacio Pijoan, L Martinez-Indart, J Escudero, J Gomez-Suarez, R Ortiz de Zarate, J Fernando Perez, P Bilbao, D Rades
PURPOSE/OBJECTIVES: To evaluate the prognostic impact of maximum standardized uptake value (SUVmax) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography/computed tomography (FDG PET/CT) imaging. MATERIALS/METHODS: Fifty-eight patients undergoing FDG PET/CT before radical treatment with definitive radiotherapy (±concomitant chemotherapy) or surgery + postoperative (chemo)radiation were analyzed...
May 24, 2017: Clinical & Translational Oncology
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