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https://www.readbyqxmd.com/read/28918183/survival-after-surgery-for-oral-cancer-a-30-year-experience
#1
T K Ong, C Murphy, A B Smith, A N Kanatas, D A Mitchell
Oral squamous cell carcinoma is the most common intraoral malignancy, for which we advocate radical primary resection with adjuvant treatment where indicated. The main aims of this paper are to identify the overall survival of a consecutive series of patients and to relate survival to clinical and pathological factors. Kaplan-Meier curves were produced for site, sex, TNM status, and use of postoperative radiotherapy. The data were analysed using IBM SPSS Statistics for Windows and probabilities of less than 0...
September 13, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28906274/flexible-bronchoscope-use-by-pulmonologists-in-collaboration-with-gastroenterologists-for-placement-of-percutaneous-endoscopic-gastrostomy-via-transnasal-route-in-patients-with-head-and-neck-cancer-a-10-year-experience-in-a-single-cancer-institution
#2
Paulo J L Mota, Jorge Dionísio, José Duro da Costa, Sandra Faias
This study was conducted with the aim of evaluating a 10-year experience in the Pulmonology Department of a cancer center for percutaneous endoscopic gastrostomy through transnasal route (TN-PEG) in patients with head and neck cancer whose oral access is precluded. This study was a retrospective analysis of 40 consecutive head and neck cancer patients referred for PEG placement, between 2005 and 2014, using a transnasal route because of the impossibility of intubation through the oral cavity. Demographics, outcome of TN-PEG procedure, indications for bronchoscopic approach (prophylactic/palliative), clinical need for bronchoscopy (trismus, oropharyngeal obstruction), location of cancer, complications, and overall survival were reviewed...
September 12, 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28892580/correlation-of-quantitative-parameters-of-magnetic-resonance-perfusion-weighted-imaging-with-vascular-endothelial-growth-factor-microvessel-density-and-hypoxia-inducible-factor-1%C3%AE-in-nasopharyngeal-carcinoma-evaluation-on-radiosensitivity-study
#3
Ying Hu, Hong E, Xiaoping Yu, Feiping Li, Longwu Zeng, Qiang Lu, Xuping Xi, Liangfang Shen
OBJECTIVES: To investigate the correlation of parameters of magnetic resonance perfusion-weighted imaging (MR-PWI) with the expression of vascular endothelial growth factor (VEGF), hypoxia-inducible factor-1α (HIF-1α) and microvessel density (MVD) in nasopharyngeal carcinoma (NPC) so as to explore the value of predicting radiosensitivity. DESIGN: A prospective study. SETTING: Department of Head-and-neck radiotherapy in Hunan Cancer Hospital...
September 11, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28892201/two-brm-promoter-polymorphisms-predict-poor-survival-in-patients-with-hepatocellular-carcinoma
#4
Ivan Pasic, Kit Man Wong, Jonghun John Lee, Osvaldo Espin-Garcia, Yonathan Brhane, Dangxiao Cheng, Zhuo Chen, Devalben Patel, Catherine Brown, Roxana Bucur, David Reisman, Jennifer J Knox, Wei Xu, Rayjean J Hung, Geoffrey Guo, Sean P Cleary
BACKGROUND: Polymorphisms in the promoter of the BRM gene, a critical subunit of the chromatin remodeling SWI/SNF complex, have previously been implicated in risk and prognosis in Caucasian-predominant lung, head and neck, esophageal, and pancreatic cancers, and in hepatocellular cancers in Asians. We investigated the role of these polymorphisms in hepatocellular carcinoma (HCC) risk and prognosis. METHODS: HCC cases were recruited in a comprehensive cancer centre while the matched controls were recruited from family practice units from the same catchment area...
September 11, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28888713/simple-and-rapid-lc-ms-ms-method-for-the-absolute-determination-of-cetuximab-in-human-serum-using-an-immobilized-trypsin
#5
Kaito Shibata, Takafumi Naito, Jun Okamura, Seiji Hosokawa, Hiroyuki Mineta, Junichi Kawakami
Proteomic approaches using liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) without an immunopurification technique have not been applied to the determination of serum cetuximab. This study developed a simple and rapid LC-MS/MS method for the absolute determination of cetuximab in human serum and applied it to clinical settings. Surrogate peptides derived from cetuximab digests were selected using a Fourier transform mass spectrometer. Reduced-alkylated serum cetuximab without immunopurification was digested for 20minutes using immobilized trypsin, and the digestion products were purified by solid-phase extraction...
August 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28887274/the-qualitative-grading-of-muscle-fat-infiltration-in-whiplash-using-fat-water-magnetic-resonance-imaging
#6
Rebecca Abbott, Anneli Peolsson, Janne West, James M Elliott, Ulrika Åslund, Anette Karlsson, Olof Dahlqvist Leinhard
BACKGROUND CONTEXT: Development of muscle fat infiltration (MFI) in the neck muscles is associated with poor functional recovery following whiplash injury. Custom software and time-consuming manual segmentation of magnetic resonance (MR) images is required for quantitative analysis and presents as a barrier for clinical translation. PURPOSE: The purpose of this work was to establish a qualitative MR measure for MFI and evaluate its ability to differentiate between individuals with severe whiplash-associated disorder (WAD), mild/moderate WAD, and healthy controls...
September 5, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28884310/radiation-induced-acute-dysphagia-prospective-observational-study-on-42%C3%A2-head-and-neck-cancer-patients
#7
D Alterio, M A Gerardi, L Cella, R Spoto, V Zurlo, A Sabbatini, C Fodor, V D'Avino, M Conson, F Valoriani, D Ciardo, R Pacelli, A Ferrari, P Maisonneuve, L Preda, R Bruschini, M Cossu Rocca, E Rondi, S Colangione, G Palma, S Dicuonzo, R Orecchia, G Sanguineti, B A Jereczek-Fossa
PURPOSE: Acute toxicity in head and neck (H&N) cancer patients treated with definitive radiotherapy (RT) has a crucial role in compliance to treatments. The aim of this study was to correlate doses to swallowing-associated structures and acute dysphagia. METHODS: We prospectively analyzed 42 H&N cancer patients treated with RT. Dysphagia (grade ≥ 3) and indication for percutaneous endoscopic gastrostomy (PEG) insertion were classified as acute toxicity. Ten swallowing-related structures were considered for the dosimetric analysis...
September 7, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28881121/the-predictable-factors-of-the-postoperative-kyphotic-change-of-sagittal-alignment-of-the-cervical-spine-after-the-laminoplasty
#8
Jun Seok Lee, Dong Wuk Son, Su Hun Lee, Dong Ha Kim, Sang Weon Lee, Geun Sung Song
OBJECTIVE: Laminoplasty is an effective surgical method for treating cervical degenerative disease. However, postoperative complications such as kyphosis, restriction of neck motion, and instability are often reported. Despite sufficient preoperative lordosis, this procedure often aggravates the lordotic curve of the cervical spine and straightens cervical alignment. Hence, it is important to examine preoperative risk factors associated with postoperative kyphotic alignment changes. Our study aimed to investigate preoperative radiologic parameters associated with kyphotic deformity post laminoplasty...
September 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28880703/the-association-between-surgical-complications-and-the-possum-score-in-head-and-neck-reconstruction-a-retrospective-single-center-study
#9
Yohjiroh Makino, Katsuhiro Ishida, Keita Kishi, Hiroki Kodama, Takeshi Miyawaki
The Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM) is widely used to predict surgical complications affecting various organs. However, there are few reports about objective evaluation methods for head and neck surgery. In this study, we retrospectively examined the association between POSSUM score and actual surgical complications of head and neck reconstruction surgery. In total, 711 patients who underwent head and neck reconstruction after cancer extirpation between January 2007 and January 2015 were studied...
September 7, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28877959/prognostic-role-of-tumour-associated-macrophages-and-regulatory-t-cells-in-ebv-positive-and-ebv-negative-nasopharyngeal-carcinoma
#10
Marc L Ooft, Jolique A van Ipenburg, Maxime E Sanders, Mariette Kranendonk, Ingrid Hofland, Remco de Bree, Senada Koljenović, Stefan M Willems
AIMS: Tumour-associated macrophages (TAMs) and regulatory T cells (Tregs) form a special niche supporting tumour progression, and both correlate with worse survival in head and neck cancers. However, the prognostic role of TAM and Tregs in nasopharyngeal carcinoma (NPC) is still unknown. Therefore, we determined differences in TAMs and Tregs in different NPC subtypes, and their prognostic significance. METHODS: Tissue of 91 NPCs was assessed for TAMs and Tregs by determination of CD68, CD163, CD206 and FOXP3 expression in the tumour microenvironment...
September 6, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28877833/effect-of-lymph-node-metastasis-on-change-of-positive-thyroglobulin-antibody-in-differentiated-thyroid-carcinoma-after-initial-treatment
#11
Teng Zhang, Li-Ping Song, Teng Zhao, Wen Gao, Yan-Song Lin
Objective To investigate the influence of lymph node metastasis on the change of positive thyroglobulin antibody(TgAb)in differentiated thyroid carcinoma after initial treatment.Methods We retrospectively analyzed the clinical data of 98 differentiated thyroid carcinoma patients with positive TgAb(≥115 IU/ml)before radioiodine(RAI)therapy.All of whom underwent total or near total thyroidectomy,neck lymph node dissection,and subsequent RAI therapy.Patients were divided into negative group(n=83)and non-negative group(n=15)according to the disappearance of positive TgAb or not after a mean follow-up of 21...
August 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28870086/histogram-analysis-of-apparent-diffusion-coefficient-maps-for-the-differentiation-between-lymphoma-and-metastatic-lymph-nodes-of-squamous-cell-carcinoma-in-head-and-neck-region
#12
Yan-Jun Wang, Xiao-Quan Xu, Hao Hu, Guo-Yi Su, Jie Shen, Hai-Bin Shi, Fei-Yun Wu
Background To clarify the nature of cervical malignant lymphadenopathy is highly important for the diagnosis and differential diagnosis of head and neck tumors. Purpose To investigate the role of first-order apparent diffusion coefficient (ADC) histogram analysis for differentiating lymphoma from metastatic lymph nodes of squamous cell carcinoma (SCC) in the head and neck region. Material and Methods Diffusion-weighted imaging (DWI) data of 67 patients (lymphoma, n = 20; SCC, n = 47) with malignant lymphadenopathy were retrospectively analyzed...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28870051/-choices-of-methods-in-dividing-the-neck-of-pancreas-in-laparoscopic-pancreaticoduodenectomy
#13
R G Lin, H G Huang, Y C Chen, F C Lu, X C Lin, Y Y Yang, H Z Fang, C F Wang
Objective: To discuss the methods, skills and experiences of dividing the neck of pancreas in laparoscopic pancreaticoduodenectomy(LPD). Methods: The clinical data of 58 patients with periampullary tumors who received LPD at the Union Hospital of Fujian Medical University from December 2014 to January 2017 were retrospectively analyzed.There were 26 males and 32 females, ranged from 18 to 65 years, with a mean age of (46±12)years. Results: All of the 58 patients underwent operation smoothly.Three cases underwent open anastomosis via an auxiliary incision after the total resection of specimen laparoscopically, due to the early learning curve of LPD...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28867558/dose-volume-histogram-analysis-of-brainstem-necrosis-in-head-and-neck-tumors-treated-using-carbon-ion-radiotherapy
#14
Katsuyuki Shirai, Kyohei Fukata, Akiko Adachi, Jun-Ichi Saitoh, Atsushi Musha, Takanori Abe, Tatsuaki Kanai, Daijiro Kobayashi, Yuka Shigeta, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno, Takashi Nakano
BACKGROUND AND PURPOSE: We aimed to evaluate the relationship between brainstem necrosis and dose-volume histograms in patients with head and neck tumors after carbon-ion radiotherapy. MATERIAL AND METHODS: We evaluated 85 patients with head and neck tumors who underwent carbon-ion radiotherapy and were followed-up for ≥12months. Brainstem necrosis was evaluated using the Common Terminology Criteria for Adverse Events (version 4.0). RESULTS: The median follow-up was 24months, and four patients developed grade 1 brainstem necrosis, with 2-year and 3-year cumulative rates of 2...
August 31, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28863405/phantom-study-evaluating-detection-of-simulated-upper-airway-occlusion-using-piezoelectric-ultrasound-transducers
#15
Mohammad Al-Abed, Peter Antich, Donald E Watenpaugh, Khosrow Behbehani
Obstructive sleep apnea/hypopnea syndrome (OSAHS) is characterized by repetitive narrowing or full collapse of the upper airway concomitant with continued respiratory effort during sleep lasting 10s or more. OSAHS is the most prevalent form of sleep-disordered breathing, affecting more than 17% of the middle-aged U.S. POPULATION: Hence, many individuals need to be tested for having OSAHS. Currently, detection of airway occlusion due to OSAHS is achieved by indirect measurements, often requiring multiple sensor types, such as a flow transducer combined with chest and abdomen plethysmography...
August 24, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28858854/photon-iso-effective-dose-for-cancer-treatment-with-mixed-field-radiation-based-on-dose-response-assessment-from-human-and-an-animal-model-clinical-application-to-boron-neutron-capture-therapy-for-head-and-neck-cancer
#16
Sara Josefina Gonzalez, Emiliano C C Pozzi, Andrea Monti Hughes, Lucas Provenzano, Hanna Koivunoro, Daniel Germán Carando, Silvia Inés Thorp, Mariana Rosalía Casal, Silva Bortolussi, Verónica A Trivillin, Marcela A Garabalino, Paula Curotto, Elisa M Heber, Gustavo A Santa Cruz, Leena Kankaanranta, Heikki Joensuu, Amanda E Schwint
Boron Neutron Capture Therapy (BNCT) is a treatment modality that combines different radiation qualities. Since the severity of biological damage following irradiation depends on the radiation type, a quantity different from absorbed dose is required to explain effects observed in the clinical BNCT in terms of outcome compared with conventional photon radiation therapy. A new approach for calculating photon iso-effective doses in BNCT was introduced previously. The present work extends this model to include information from dose-response assessments in animal models and humans...
August 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28857306/the-effect-of-targeted-therapy-on-recruited-cancer-stem-cells-in-a-head-and-neck-carcinoma-model
#17
Loredana G Marcu, David Marcu
OBJECTIVE: Head and neck cancers (HNC) are known for their repopulation ability driven by cancer stem cells (CSCs). While a small fraction of CSCs proliferates, there are quiescent CSCs that are long-lived and reside outside the cell cycle. Recruitment of quiescent CSCs into the cycle occurs as a response to cell loss and their proliferation may lead to treatment failure. Therefore, CSCs require a more targeted approach to be destroyed. An agent that sensitizes CSC response to treatment is all-trans-retinoic acid (ATRA)...
August 30, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28852427/seven-cpg-based-prognostic-signature-coupled-with-gene-expression-predicts-survival-of-oral-squamous-cell-carcinoma
#18
Sipeng Shen, Guanrong Wang, Qianwen Shi, Ruyang Zhang, Yang Zhao, Yongyue Wei, Feng Chen, David C Christiani
BACKGROUND: DNA methylation has started a recent revolution in genomics biology by identifying key biomarkers for multiple cancers, including oral squamous cell carcinoma (OSCC), the most common head and neck squamous cell carcinoma. METHODS: A multi-stage screening strategy was used to identify DNA-methylation-based signatures for OSCC prognosis. We used The Cancer Genome Atlas (TCGA) data as training set which were validated in two independent datasets from Gene Expression Omnibus (GEO)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28840118/designing-an-optimized-novel-femoral-stem
#19
Parto Babaniamansour, Mehdi Ebrahimian-Hosseinabadi, Anousheh Zargar-Kharazi
BACKGROUND: After total hip arthroplasty, there would be some problems for the patients. Implant loosening is one of the significant problems which results in thigh pain and even revision surgery. Difference between Young's modulus of bone-metal is the cause of stress shielding, atrophy, and subsequent implant loosening. MATERIALS AND METHODS: In this paper, femoral stem stiffness is reduced by novel biomechanical and biomaterial design which includes using proper design parameters, coating it with porous surface, and modeling the sketch by the software...
July 2017: Journal of Medical Signals and Sensors
https://www.readbyqxmd.com/read/28836005/grading-dysphagia-as-a-toxicity-of-head-and-neck-cancer-differences-in-severity-classification-based-on-mbs-digest-and-clinical-ctcae-grades
#20
Ryan P Goepfert, Jan S Lewin, Martha P Barrow, Carla L Warneke, Clifton D Fuller, Stephen Y Lai, Randal S Weber, Katherine A Hutcheson
Clinician-reported toxicity grading through common terminology criteria for adverse events (CTCAE) stages dysphagia based on symptoms, diet, and tube dependence. The new dynamic imaging grade of swallowing toxicity (DIGEST) tool offers a similarly scaled five-point ordinal summary grade of pharyngeal swallowing as determined through results of a modified barium swallow (MBS) study. This study aims to inform clinicians on the similarities and differences between dysphagia severity according to clinical CTCAE and MBS-derived DIGEST grading...
August 23, 2017: Dysphagia
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