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https://www.readbyqxmd.com/read/27930697/early-antenatal-prediction-of-gestational-diabetes-in-obese-women-development-of-prediction-tools-for-targeted-intervention
#1
Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy
All obese women are categorised as being of equally high risk of gestational diabetes (GDM) whereas the majority do not develop the disorder. Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. Our aim was to develop a prediction tool for early identification of obese women at high risk of GDM to facilitate targeted interventions in those most likely to benefit. Clinical and anthropometric data and non-fasting blood samples were obtained at 15+0-18+6 weeks' gestation in 1303 obese pregnant women from UPBEAT, a randomised controlled trial of a behavioural intervention...
2016: PloS One
https://www.readbyqxmd.com/read/27927507/sacral-alar-iliac-fixation-in-pediatric-deformity-radiographic-outcomes-and-complications
#2
Amit Jain, Khaled M Kebaish, Paul D Sponseller
STUDY DESIGN: Retrospective case series. OBJECTIVES: To assess the radiographic outcomes and complications of sacral-alar-iliac (SAI) fixation in children. SUMMARY OF BACKGROUND DATA: Pelvic fixation in children undergoing spinal deformity surgery can be challenging because of complex anatomy, compound biomechanical forces at the lumbosacral junction, and poor bone quality. METHODS: Radiographic and clinical records of 80 consecutive patients aged 18 years or younger who underwent posterior spinal fusion surgery with SAI fixation by one pediatric orthopedic surgeon and who had a minimum 2 years of follow-up (mean follow-up: 3...
May 2016: Spine Deformity
https://www.readbyqxmd.com/read/27926848/constriction-by-dynamin-elasticity-versus-adhesion
#3
Zachary A McDargh, Pablo Vázquez-Montejo, Jemal Guven, Markus Deserno
Any cellular fission process is completed when the neck connecting almost-separate membrane compartments is severed. This crucial step is somehow accomplished by proteins from the dynamin family, which polymerize into helical spirals around such necks. Much research has been devoted to elucidating the specifics of that somehow, but despite no shortage of ideas, the question is not settled. Pictorially obvious notions of strangling or pushing are difficult to render in mechanically precise terms. Moreover, because dynamin is a GTPase, it is tempting to speculate that it has a motor activity that assists the necessary severing action, but again the underlying mechanics is not obvious...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27919471/microvascular-coupling-devices-neglected-resource-with-a-short-learning-curve
#4
W R Thompson, A Burns, S Endersby, M Nugent
Microvascular couplers have a record of efficiency and efficacy. They have been used in anastomoses in the head and neck in Sunderland since November 2013, where we have investigated the time taken for anastomosis, patency, and cost. We also completed a national survey of the use of couplers in the United Kingdom, in which we recorded the time of anastomosis. The mean (range) time was 4minutes (2minutes 40seconds - 4minutes 10seconds). One flap partially failed. This shows that couplers can save time, they have successful outcomes, and the technique is quick and easy to learn...
December 2, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27917662/validating-a-benchmarking-tool-for-audit-of-early-outcomes-after-operations-for-head-and-neck-cancer
#5
D Tighe, I Sassoon, M McGurk
INTRODUCTION In 2013 all UK surgical specialties, with the exception of head and neck surgery, published outcome data adjusted for case mix for indicator operations. This paper reports a pilot study to validate a previously published risk adjustment score on patients from separate UK cancer centres. METHODS A case note audit was performed of 1,075 patients undergoing 1,218 operations for head and neck squamous cell carcinoma under general anaesthesia in 4 surgical centres. A logistic regression equation predicting for all complications, previously validated internally at sites A-C, was tested on a fourth external validation sample (site D, 172 operations) using receiver operating characteristic curves, Hosmer-Lemeshow goodness of fit analysis and Brier scores...
December 5, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27903486/predictive-models-of-complications-following-endovascular-aortic-aneurysm-repair
#6
Adrien Kaladji, Anne Daoudal, Aurélien Duménil, Cemil Göksu, Alain Cardon, Elodie Clochard, Antoine Lucas, Florent Lalys
BACKGROUND: The risk of long-term complications after endovascular aneurysm repair (EVAR) is still higher than open surgery and is a critical issue. This study aims to make available reliable statistical predictive models of complications after EVAR. METHODS: Two hundred and thirteen patients who underwent EVAR between 2002 and 2012 were included in this study. The preoperative CT-scans were analyzed with a dedicated workstation to provide spatially correct 3-dimensional data...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27895406/simplified-criteria-for-diagnosing-superficial-esophageal-squamous-neoplasms-using-narrow-band-imaging-magnifying-endoscopy
#7
Akira Dobashi, Kenichi Goda, Noboru Yoshimura, Tomohiko R Ohya, Masayuki Kato, Kazuki Sumiyama, Masato Matsushima, Shinichi Hirooka, Masahiro Ikegami, Hisao Tajiri
AIM: To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma (SESCC) on Narrow Band Imaging combined with magnifying endoscopy (NBI-ME). METHODS: This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopists detected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops (IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes (VS)" of IPCLs (i...
November 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27890427/internal-and-external-generalizability-of-temporal-dose-response-relationships-for-xerostomia-following-imrt-for-head-and-neck-cancer
#8
Maria Thor, Adepitan A Owosho, Haley D Clark, Jung Hun Oh, Nadeem Riaz, Allan Hovan, Jillian Tsai, Steven D Thomas, Sae Hee K Yom, Jonn S Wu, Joseph M Huryn, Vitali Moiseenko, Nancy Y Lee, Cherry L Estilo, Joseph O Deasy
BACKGROUND AND PURPOSE: To study internal and external generalizability of temporal dose-response relationships for xerostomia after intensity-modulated radiotherapy (IMRT) for head and neck cancer, and to investigate potential amendments of the QUANTEC guidelines. MATERIAL AND METHODS: Objective xerostomia was assessed in 121 patients (nCohort1=55; nCohort2=66) treated to 70Gy@2Gy in 2006-2015. Univariate and multivariate analyses (UVA, MVA with 1000 bootstrap populations) were conducted in Cohort1, and generalizability of the best-performing MVA model was investigated in Cohort2 (performance: AUC, p-values, and Hosmer-Lemeshow p-values (pHL))...
November 24, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27882691/image-guided-fna-cytology-and-flow-cytometry-phenotyping-of-neck-lymphadenopathy-for-the-diagnosis-of-recurrent-lymphoma
#9
F Lumachi, A Fassina, R Tozzoli, A Tregnaghi, S M M Basso, M Ermani
OBJECTIVE: In patients with a history of lymphoma, each lymphadenopathy should be carefully evaluated. The aims of this study were to evaluate (i) the usefulness of high-resolution ultrasonography (US), US-guided fine-needle aspiration cytology (FNAC) and flow cytometry phenotyping (FCP) together in the diagnosis of recurrent lymphoma, and (ii) whether these tools were independent predictors of correct results. DESIGN: Retrospective cohort study with stepwise forward logistic regression analysis of results...
November 24, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/27881143/weekly-versus-every-three-weeks-platinum-based-chemoradiation-regimens-for-head-and-neck-cancer
#10
James M Melotek, Benjamin T Cooper, Matthew Koshy, Joshua S Silverman, Michael T Spiotto
BACKGROUND: The majority of chemoradiation (CRT) trials for locally advanced head and neck squamous cell carcinoma (HNSCC) have relied on platinum-based chemotherapy regimens administered every-3-weeks. However, given the increased utilization of weekly platinum regimens, it remains unclear how different chemotherapy schedules compare regarding efficacy and toxicity. METHODS: We retrospectively identified 212 patients with HNSCC who were treated at a single academic medical center with concurrent platinum-based CRT given weekly (N = 68) or every-three-weeks (N = 144)...
November 24, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27880733/an-automated-workflow-for-patient-specific-quality-control-of-contour-propagation
#11
William J Beasley, Alan McWilliam, Nicholas J Slevin, Ranald I Mackay, Marcel van Herk
Contour propagation is an essential component of adaptive radiotherapy, but current contour propagation algorithms are not yet sufficiently accurate to be used without manual supervision. Manual review of propagated contours is time-consuming, making routine implementation of real-time adaptive radiotherapy unrealistic. Automated methods of monitoring the performance of contour propagation algorithms are therefore required. We have developed an automated workflow for patient-specific quality control of contour propagation and validated it on a cohort of head and neck patients, on which parotids were outlined by two observers...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27872746/a-prospective-cohort-study-to-assess-the-role-of-fdg-pet-in-differentiating-benign-and-malignant-follicular-neoplasms
#12
K Alok Pathak, Andrew L Goertzen, Richard W Nason, Thomas Klonisch, William D Leslie
BACKGROUND: Follicular and Hürthle cell neoplasms are diagnostic challenges. This prospective study was designed to evaluate the efficacy of [18F]-2-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in predicting the risk of malignancy in follicular/Hürthle cell neoplasms. MATERIALS AND METHODS: Fifty thyroid nodules showing follicular/Hürthle cell neoplasm on prior ultrasonography guided fine needle aspiration cytology (FNAC) were recruited into this study...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27868287/development-of-a-nomogram-for-the-prediction-of-pathological-complete-response-after-neoadjuvant-chemoradiotherapy-in-patients-with-esophageal-squamous-cell-carcinoma
#13
Yin-Kai Chao, Hsien-Kun Chang, Chen-Kan Tseng, Yun-Hen Liu, Yu-Wen Wen
Nomograms incorporating multiple prognostic factors are useful for individualized estimation of survival in cancer patients. However, nomograms for the prediction of pathological complete response (pCR) after neoadjuvant chemoradiotherapy (nCRT) in patients with esophageal cancer are scarce. Here, we describe the development of a nomogram for predicting pCR after nCRT in patients with esophageal squamous cell carcinoma (ESCC). We retrospectively reviewed the records of 392 ESCC patients who underwent nCRT followed by esophagectomy...
November 21, 2016: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/27867888/neck-height-ratio-is-an-important-predictor-of-metabolic-syndrome-among-asian-indians
#14
Chitra Selvan, Deep Dutta, Anubhav Thukral, Titli Nargis, Manoj Kumar, Satinath Mukhopadhyay, Subhankar Chowdhury
BACKGROUND AND AIMS: The predictive potential of neck circumference (NC) based indices (a measure of upper body fat distribution) for predicting metabolic syndrome (MetS) and its components among Indians is not known. This study aimed to evaluate the role of NC and neck height ratio (NHtR) as independent predictors of MetS and its components as compared to traditional anthropometric indices. MATERIALS AND METHODS: A total of 451 individuals from 867 screened individuals, 30-80 years age, without any co-morbid state who gave informed written consent underwent clinical, anthropometric, and biochemical assessment...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27866310/prediction-of-difficult-laryngoscopy-using-spirometry-a-pilot-study
#15
Serkan Dogru, Tugba Karaman, Aynur Sahin, Hakan Tapar, Serkan Karaman, Semih Arici, Mustafa Suren, Ziya Kaya, Battal Tahsin Somuk
Prediction of difficult laryngoscopy is still the uncovered secret of anesthetic practice. This pilot study is aimed to assess the efficacy of spirometry measurements in predicting difficult laryngoscopy compared with conventional airway assessment techniques. We enrolled 202 adults, ages 18-40 years, with an American Society of Anaesthesiologists score of I or II, scheduled for elective surgery and undergoing general anesthesia. Spirometry was used for lung capacity measurements before the operation. The Mallampati classification, neck circumference, sternomental distance, thyromental distance, maximum mouth-opening measurement, and upper lip bite test of the subjects were measured...
November 19, 2016: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/27859312/nomogram-for-predicting-central-node-metastasis-in-papillary-thyroid-carcinoma
#16
Seo Ki Kim, Young Jun Chai, Inhye Park, Jung-Woo Woo, Jun Ho Lee, Kyu Eun Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: There was a difficulty for detecting Central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) patients. Therefore, the purpose of this study was to design a nomogram for predicting CLNM. METHODS: A total of 10,763 PTC patients who underwent total thyroidectomy with central neck dissection (CND) in Samsung Medical Center were randomly assigned to the training set (n = 7,535) and to the internal validation set (n = 3,228). And, a total of 2,514 PTC patients who underwent total thyroidectomy with CND at Seoul National University Hospital were assigned to the external validation set...
November 18, 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27856383/the-woven-endobridge-web-device-for-treatment-of-intracranial-aneurysms-a-systematic-review
#17
REVIEW
I S Muskens, J T Senders, H H Dasenbrock, T R S Smith, M L D Broekman
INTRODUCTION: The WovenEndobridge (WEB) device is an innovative endovascular device for treatment of intracranial aneurysms, especially bifurcation and wide-neck aneurysms. Although not FDA approved, it has been available in Europe since 2011. The aim of this review is to evaluate the outcomes of WEB device use for intracranial aneurysm treatment. METHODS: A systematic review was conducted with MEDLINE search engines PubMed and Embase from 2011. The search strategy provided 6229 articles, and 19 articles were included...
November 14, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27855253/-musculoskeletal-disorders-and-temporary-disability-characteristics-and-duration-catalonia-2007-2010
#18
Ignasi Manent Bistué, José Mª Ramada Rodilla, Consol Serra Pujadas
BACKGROUND: Musculoskeletal disorders (MSD) are the leading cause of sickness absence (SA) in Spain and the second in Catalonia. A greater knowledge of this field could allow the refocusing of social protection policies and interventions to reduce their frequency and duration. The objective of the study was to describe the characteristics and duration of SA due to MSD in Catalonia between 2007 and 2010. METHODS: The study population included all incident SA episodes due to MSD during the period 2007-2010, registered in the Institut Català d'AvaluacionsMèdiques (ICAM) database...
October 2016: Archivos de Prevención de Riesgos Laborales
https://www.readbyqxmd.com/read/27837418/multi-slice-spect-ct-vs-lymphoscintigraphy-and-intraoperative-gamma-ray-probe-for-sentinel-node-mapping-in-hnscc
#19
C M Meerwein, T Sekine, P Veit-Haibach, M G Bredell, G F Huber, M W Huellner
To assess the diagnostic potential of multi-slice single-photon emission computed tomography/computed tomography (SPECT/CT) for preoperative sentinel node (SN) mapping in early stage head and neck squamous cell carcinoma (HNSCC). Retrospective case-control study including data of consecutive HNSCC patients treated between November 2011 and December 2015. The diagnostic accuracy of multi-slice SPECT/CT was assessed with regard to the gold standard intraoperative gamma ray detection probe, using McNemar's test and calculating the area under the ROC curve...
November 11, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27837321/hemiarthroplasty-versus-internal-fixation-in-super-aged-patients-with-undisplaced-femoral-neck-fractures-a-5-year-follow-up-of-randomized-controlled-trial
#20
Qifeng Lu, Genling Tang, Xijiang Zhao, Shuguang Guo, Bin Cai, Qingsong Li
INTRODUCTION: There were higher rates of revision, complication, non-union, delayed union, and poorer functional outcomes reported in super-aged patients of undisplaced femoral neck fractures treated with internal fixation. Therefore, we designed this randomized comparative study aiming to compare the effectiveness and long-term follow-up results of hemiarthroplasty (HA) with that of multiple cannulated screws (MCS). MATERIALS AND METHODS: Eligible participants were randomly assigned into two groups for different methods of operation (hemiarthroplasty group and internal fixation group)...
November 11, 2016: Archives of Orthopaedic and Trauma Surgery
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