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https://www.readbyqxmd.com/read/28540535/prognostic-value-of-maximum-standardized-uptake-value-measured-by-pretreatment-18f-fdg-pet-ct-in-locally-advanced-head-and-neck-squamous-cell-carcinoma
#1
J Cacicedo, I Fernandez, O Del Hoyo, A Navarro, A Gomez-Iturriaga, J Ignacio Pijoan, L Martinez-Indart, J Escudero, J Gomez-Suarez, R Ortiz de Zarate, J Fernando Perez, P Bilbao, D Rades
PURPOSE/OBJECTIVES: To evaluate the prognostic impact of maximum standardized uptake value (SUVmax) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC) undergoing pretreatment [F-18] fluoro-D-glucose-positron emission tomography/computed tomography (FDG PET/CT) imaging. MATERIALS/METHODS: Fifty-eight patients undergoing FDG PET/CT before radical treatment with definitive radiotherapy (±concomitant chemotherapy) or surgery + postoperative (chemo)radiation were analyzed...
May 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28537925/preoperative-vitamin-d-deficiency-and-postoperative-hypocalcemia-in-thyroid-cancer-patients-undergoing-total-thyroidectomy-plus-central-compartment-neck-dissection
#2
Xiaofei Wang, Jingqiang Zhu, Feng Liu, Yanping Gong, Zhihui Li
BACKGROUND: There appears to be a lack of consensus whether preoperative vitamin D deficiency (VDD) increases the risk of postoperative hypocalcemia and decreases the accuracy of postoperative parathyroid hormone (PTH) in predicting hypocalcemia in thyroid cancer patients undergoing total thyroidectomy (TT) plus central compartment neck dissection (CCND). This study aims to address these issues. METHOD: All consecutive thyroid cancer patients who underwent TT plus CCND were retrospectively reviewed through a prospectively collected database between October 2015 and April 2016 in a tertiary referral hospital...
May 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28535963/usefulness-of-11-c-methionine-pet-for-predicting-the-efficacy-of-carbon-ion-radiation-therapy-for-head-and-neck-mucosal-malignant-melanoma
#3
M Hasebe, K Yoshikawa, R Nishii, K Kawaguchi, T Kamada, Y Hamada
The aim of this study was to determine whether l-methyl-[(11)C]-methionine (MET) positron emission tomography (PET) allows the prediction of outcomes in patients with head and neck mucosal malignant melanoma treated with carbon ion radiation therapy (CIRT). This was a retrospective cohort study involving 85 patients who underwent a MET-PET or MET-PET/computed tomography (CT) examination before and after CIRT. MET uptake in the tumour was evaluated semi-quantitatively using the tumour-to-normal tissue ratio (TNR)...
May 20, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28532053/functionalized-fe3o4-graphene-oxide-nanocomposites-with-hairpin-aptamers-for-the-separation-and-preconcentration-of-trace-pb-2-from-biological-samples-prior-to-determination-by-icp-ms
#4
Mojtaba Shamsipur, Leila Farzin, Mahmoud Amouzadeh Tabrizi, Shahab Sheibani
Lead (Pb) as a topically poisonous metal represents a serious threat to the ecological environment and especially to human beings. Therefore, it is urgent to develop a rapid and reliable monitoring technique for this heavy metal in the environmental samples. In the present study, we have designed a selective and sensitive method for the determination of ultratrace contents of Pb(2+) in biological samples, based on the guanine (G)-quadruplex formed by the aptamer with hairpin structure and Pb(2+). For this purpose, Pb(2+) specific aptamer serving as affinity probe to capture and separate trace amounts of the analyte, was covalently linked to Fe3O4/graphene oxide (GO) surface by using a suitable cross-linking agent...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28527720/overactive-bladder-oab-a-symptom-in-search-of-a-disease-its-relationship-to-specific-lower-urinary-tract-symptoms-and-conditions
#5
Jason P Van Batavia, Andrew J Combs, Angela M Fast, Kenneth I Glassberg
BACKGROUND: The ICCS defines OAB by the subjective symptom of urgency; detrusor overactivity (DO) is only implied. While no other symptom is required, OAB can also be associated with urinary frequency, decreased functional bladder capacity, and incontinence. OBJECTIVE: We sought to determine how often these associated findings occur in OAB and what if any uroflow/EMG-defined conditions are found to be associated with it. METHODS: The charts of 548 children (231M, 318F; mean age 9...
March 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28524416/diagnostic-ultrasound-of-the-vagus-nerve-in-patients-with-diabetes
#6
Eman A Tawfik, Francis O Walker, Michael S Cartwright, Rana A El-Hilaly
BACKGROUND AND PURPOSE: Autonomic neuropathy is a serious and common complication of diabetes mellitus. The vagus nerve is the longest autonomic nerve, and may be affected in diabetes as a part of generalized neuropathy. Our objective was to assess for possible sonographic changes of the vagus nerve in diabetic patients. METHODS: The vagus nerve was bilaterally scanned in 20 healthy volunteers and 54 patients with diabetes in the axial plane at the lateral neck...
May 19, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28520896/laser-assisted-indocyanine-green-dye-angiography-for-postoperative-fistulas-after-salvage-laryngectomy
#7
Erin J Partington, Lindsay S Moore, Russel Kahmke, Jason M Warram, William Carroll, Eben L Rosenthal, Benjamin J Greene
Importance: Pharyngocutaneous fistula formation is an unfortunate complication after salvage laryngectomy for head and neck cancer that is difficult to anticipate and related to a variety of factors, including the viability of native pharyngeal mucosa. Objective: To examine whether noninvasive angiography with indocyanine green (ICG) dye can be used to evaluate native pharyngeal vascularity to anticipate pharyngocutaneous fistula development. Design, Setting, and Participants: This cohort study included 37 patients enrolled from June 1, 2013, to June 1, 2016, and follow-up was for at least 1 month postoperatively...
May 18, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28511949/serum-metal-levels-for-diagnosis-of-adverse-local-tissue-reactions%C3%A2-secondary-to-corrosion-in-metal-on-polyethylene-total%C3%A2-hip%C3%A2-arthroplasty
#8
Yale A Fillingham, Craig J Della Valle, Daniel D Bohl, Mick P Kelly, Deborah J Hall, Robin Pourzal, Joshua J Jacobs
BACKGROUND: Recently, corrosion at the head-neck junction in metal-on-polyethylene bearing surface total hip arthroplasty (THA) has been recognized as a cause of adverse local tissue reactions (ALTRs). Serum metal levels have been advocated as a tool for the diagnosis of ALTR; however, no prior studies have specifically examined their utility. The purpose of this study was to determine the optimal cutoff values for serum cobalt and chromium levels in diagnosing ALTR after metal-on-polyethylene bearing surface THA...
April 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28510598/age-gender-neck-circumference-and-epworth-sleepiness-scale-do-not-predict-obstructive-sleep-apnea-osa-in-moderate-to-severe-chronic-obstructive-pulmonary-disease-copd-the-challenge-to-predict-osa-in-advanced-copd
#9
Xavier Soler, Shu-Yi Liao, Jose Maria Marin, Geraldo Lorenzi-Filho, Rachel Jen, Pamela DeYoung, Robert L Owens, Andrew L Ries, Atul Malhotra
The combination of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) is associated with substantial morbidity and mortality. We hypothesized that predictors of OSA among patients with COPD may be distinct from OSA in the general population. Therefore, we investigated associations between traditional OSA risk factors (e.g. age), and sleep questionnaires [e.g. Epworth Sleepiness Scale] in 44 patients with advanced COPD. As a second aim we proposed a pilot, simplified screening test for OSA in patients with COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28506831/cryab-promotes-the-invasion-and-metastasis-of-colorectal-cancer-via-epithelial-mesenchymal-transition
#10
Chuanbing Shi, Xiaojun Yang, Xiaodong Bu, Ning Hou, Pingsheng Chen
Alpha B-crystallin (CRYAB, HSPB5) is a protein that was first discovered in the lens of the eye. It is a member of the small heat-shock protein family (sHsps). CRYAB functions primarily as a molecular chaperone to prevent the aggregation and degradation of damaged unfolded proteins due to cellular damage resulting from heat shock, radiation, oxidative stress, and other insults, thereby promoting cell survival and preventing apoptosis. In recent years, the role of CRYAB in tumorigenesis, tumor invasion, and metastasis has received increasing attention...
May 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28502238/parotid-gland-mean-dose-as-a-xerostomia-predictor-in-low-dose-domains
#11
Hubert Szymon Gabryś, Florian Buettner, Florian Sterzing, Henrik Hauswald, Mark Bangert
PURPOSE: Xerostomia is a common side effect of radiotherapy resulting from excessive irradiation of salivary glands. Typically, xerostomia is modeled by the mean dose-response characteristic of parotid glands and prevented by mean dose constraints to either contralateral or both parotid glands. The aim of this study was to investigate whether normal tissue complication probability (NTCP) models based on the mean radiation dose to parotid glands are suitable for the prediction of xerostomia in a highly conformal low-dose regime of modern intensity-modulated radiotherapy (IMRT) techniques...
May 13, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28495058/mirna-profiling-of-primary-lung-and-head-and-neck-squamous-cell-carcinomas-addressing-a-diagnostic-dilemma
#12
Juan A Muñoz-Largacha, Adam C Gower, Praveen Sridhar, Anita Deshpande, Carl J O'Hara, Emiko Yamada, Tony E Godfrey, Hiran C Fernando, Virginia R Litle
OBJECTIVE: To determine whether microRNA (miRNA) profiling of primary lung and head and neck squamous cell carcinomas could be useful to identify a specific miRNA signature that can be used to further discriminate between primary lung squamous carcinomas and metastatic lesions in patients with a history of head and neck squamous cell cancer. METHODS: Specimens of resected primary head and neck and lung squamous cell carcinomas were obtained from formalin-fixed, paraffin-embedded blocks...
April 12, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28494066/association-between-middle-ear-cholesteatoma-and-chronic-rhinosinusitis
#13
Chin-Lung Kuo, Yu-Chun Yen, Wei-Pin Chang, An-Suey Shiao
Importance: Chronic rhinosinusitis (CRS) can cause an obstruction of the tubal orifice and thereby compromise ventilation of the middle ear. The resulting negative pressure in the middle ear may, in turn, lead to the formation of an eardrum retraction pocket and subsequent acquired cholesteatoma. This study hypothesizes that CRS may increase the risk of cholesteatoma. Objective: To evaluate the risk of cholesteatoma in patients with CRS. Design, Setting, and Participants: This study used a nationwide, population-based claims database to test the hypothesis that CRS may increase the risk of cholesteatoma...
May 11, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28488070/cerebral-aneurysm-neck-diameter-is-an-independent-predictor-of-progressive-occlusion-after-stent-assisted-coiling
#14
Masahito Nakazaki, Tadashi Nonaka, Tatsufumi Nomura, Toshiyuki Onda, Yasuyuki Yonemasu, Akira Takahashi, Yuji Hashimoto, Osamu Honda, Shinichi Oka, Masanori Sasaki, Masahiko Daibo, Osamu Honmou
BACKGROUND: Some intracranial aneurysms treated by stent-assisted coiling (SAC) with incomplete occlusion undergo progressive occlusion (PO) during follow-up period. We analyzed the predictors for the occurrence of PO. METHODS: Among 74 cerebral aneurysms treated by SAC using the Enterprise or Neuroform stents from 2010 to 2015, we included 43 aneurysms with occlusion grade of neck remnant (NR, n = 36) or residual aneurysm (RA, n = 7) at the post-procedure. We defined PO as improvement in occlusion grade from RA to NR, or from NR or RA to complete occlusion on angiographic follow-up imaging at 6 months after the procedure...
May 9, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28476870/plasma-methoxytyramine-clinical-utility-with-metanephrines-for-diagnosis-of-pheochromocytoma-and-paraganglioma
#15
Dipti Rao, Mirko Peitzsch, Aleksander Prejbisz, Katharzyna Hanus, Martin Fassnacht, Felix Beuschlein, Christina Brugger, Stephanie Fliedner, Katharina Langton, Christina Pamporaki, Volker Gudziol, Anthony Stell, Andrzej Januszewicz, Henri J Timmers, Jacques Lenders, Graeme Eisenhofer
CONTEXT: Measurements of plasma methoxytyramine, the O-methylated dopamine metabolite, are useful for detecting rare dopamine-producing pheochromocytomas and paragangliomas (PPGLs) and head and neck paragangliomas (HNPGLs), but utility for screening beyond that achieved using standard measurements of normetanephrine and metanephrine is unclear. OBJECTIVE: Evaluation of the additional utility of methoxytyramine compared to plasma normetanephrine and metanephrine for diagnosis of PPGLs and HNPGLs...
May 5, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28473292/risk-factors-and-the-preoperative-assessment-of-right-para-oesophageal-lymph-node-metastasis-in-right-lobe-papillary-thyroid-carcinoma-a-case-series
#16
You Qu, Hao Zhang, Ping Zhang, Wenwu Dong, Liang He, Wei Sun, Jinhao Liu
BACKGROUND: Right para-oesophageal lymph nodes (RPELN) are included among the right central compartment lymph nodes (rCLN) and located behind right recurrent laryngeal nerve (rRLN). However, due to the likelihood of increasing postoperative complications, and the extremely difficulties of RPELN dissection, the decision to perform RPELN dissection remains controversial. The aim of this study was to explore the risk factors of RPELN metastasis and evaluate RPELN metastasis by preoperative examination...
May 1, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28473272/novel-application-of-a-rigid-curved-larygno-pharyngoscope-for-examination-and-treatment-of-hypopharyngeal-lesions
#17
Kenichi Watanabe, Daisuke Yamauchi, Yoshitaka Takanashi, Hiroshi Hidaka, Yukio Katori
In endoscopic laryngo-pharyngeal surgery (ELPS), a rigid curved laryngo-pharyngoscope, which was invented by Dr. Sato et al., is necessary to obtain excellent surgical view of both hypopharynx and even the entrance of the esophagus. We have used this instrument for the examination and treatment of several diseases other than cancer located in the hypopharynx, such as difficult-to-find buried fish bones, retropharyngeal abscess, and congenital pyriform sinus fistula. In the result, we could acquire better view of hypopharynx and completed the intended procedure safely, especially for uncovering difficult-to-find fish bone buried in the mucosa...
May 1, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28460811/do-we-need-a-change-in-ed-diagnostic-strategy-for-adult-acute-epiglottitis
#18
Sun Hwa Lee, Seong Jong Yun, Dong Hyeon Kim, Hyeon Hwan Jo, Seokyong Ryu
OBJECTIVES: To retrospectively evaluate the diagnostic performance of qualitative and quantitative radiographic parameters for diagnosing adult acute epiglottitis, and identify the prevalence and risk factors of false-negative neck radiography-based diagnosis of acute epiglottitis. METHODS: An emergency physician and a radiologist independently reviewed neck radiographs of 91 patients with laryngoscopy-confirmed acute epiglottitis and 91 control subjects between March 2010 and June 2016 for qualitative and quantitative radiographic parameters of acute epiglottitis, and concluded a diagnosis...
April 20, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28448423/dual-energy-ct-balance-between-iodine-attenuation-and-artifact-reduction-for-the-evaluation-of-head-and-neck-cancer
#19
Jaykumar R Nair, François DeBlois, Thomas Ong, Slobodan Devic, Nada Tomic, Hamed Bekerat, Lorne Rosenbloom, Khalil Sultanem, Reza Forghani
OBJECTIVE: Dual-energy computed tomography high energy virtual monochromatic images (VMIs) can reduce artifact but suppress iodine attenuation in enhancing tumor. We investigated this trade-off to identify VMI(s) that strike the best balance between iodine detection and artifact reduction. METHODS: The study was performed using an Alderson radiation therapy phantom. Different iodine solutions (based on estimated tumor iodine content in situ using dual-energy computed tomography material decomposition) and different dental fillings were investigated...
April 26, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28448310/comparison-of-power-versus-manual-injection-in-bolus-shape-and-image-quality-on-contrast-enhanced-magnetic-resonance-angiography-an-experimental-study-in-a-swine-model
#20
Takahiro Tsuboyama, Gregor Jost, Hubertus Pietsch, Noriyuki Tomiyama
OBJECTIVE: The aim of this study was to compare power versus manual injection in bolus shape and image quality on contrast-enhanced magnetic resonance angiography (CE-MRA). MATERIALS AND METHODS: Three types of CE-MRA (head-neck 3-dimensional [3D] MRA with a test-bolus technique, thoracic-abdominal 3D MRA with a bolus-tracking technique, and thoracic-abdominal time-resolved 4-dimensional [4D] MRA) were performed after power and manual injection of gadobutrol (0...
April 26, 2017: Investigative Radiology
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