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https://www.readbyqxmd.com/read/28716437/tumor-programmed-cell-death-ligand-1-expression-correlates-with-nodal-metastasis-in-patients-with-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#1
Juana María García-Pedrero, Pablo Martínez-Camblor, Susana Diaz-Coto, Pablo Munguia-Calzada, Aitana Vallina-Alvarez, Francisco Vazquez-Lopez, Juan Pablo Rodrigo, Jorge Santos-Juanes
BACKGROUND: Binding of tumor-expressed programmed cell death ligand 1 (PD-L1) to the programmed cell death 1 (PD-1) surface receptor blocks T-cell activation thereby leading to immune evasion. Tumor PD-L1 expression has been associated with poor outcome in a wide variety of cancers; however, data in cutaneous squamous cell carcinoma (cSCC) are scarce and conflicting. OBJECTIVE: To investigate the relationship of tumor PD-L1 expression with the clinicopathologic features and prognosis of cSCC...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28713698/robotic-retroauricular-thyroidectomy-initial-experience-from-india
#2
REVIEW
Krishnakumar Thankappan, Surender Dabas, Mandar Deshpande
Robotic thyroidectomy is getting accepted worldwide, but, majority of the literature is from South Korea. The purpose of this paper is to review the early experiences with robotic retroauricular (RA) thyroidectomy from India. The rationale for robotic thyroidectomy, its advantages and disadvantages are reviewed. The reasons for selecting the RA approach and the criteria used for selecting the patients are discussed. The early experience and outcomes of 29 patients, from three centres across India is presented...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28713697/safe-implementation-of-retroauricular-robotic-and-endoscopic-neck-surgery-in-south-america
#3
REVIEW
Renan Bezerra Lira, Thiago Celestino Chulam, Luiz Paulo Kowalski
In the last three decades, otolaryngology and head and neck oncological surgery have shown remarkable progress with the development of several modalities of endoscopic-assisted minimally invasive surgeries. More recently, the Da Vinci robotic surgery system has promoted the development of several surgical approaches with less morbidity and better cosmetic results, including the transaxillary and retroauricular approaches for thyroid surgery and neck dissections. In South America, there are several shortcomings regarding financial resources as well as the lack of support for innovation leading to a significant delay in adoption of numerous technological advances in medical practice...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28711205/dual-energy-computed-tomography-applications-for-the-evaluation-of-cervical-lymphadenopathy
#4
REVIEW
Ahmed M Tawfik, Andreas Michael Bucher, Thomas J Vogl
There is recent interest in the use of dual-energy computed tomography (CT) in head and neck imaging, and the results are encouraging. This article reviews dual-energy CT applications as complementary tools to conventional CT scanning in the evaluation of cervical lymphadenopathy. The article cites the most relevant studies and highlights their results. Single-source and dual-source dual-energy applications including virtual noncontrast images, linear and nonlinear image blending, monochromatic images, iodine quantification, and spectral Hounsfield unit attenuation curve analysis are reviewed...
August 2017: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/28702415/impact-and-prognostic-value-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scan-in-the-evaluation-of-residual-head-and-neck-cancer-single-center-experience-from-pakistan
#5
Saima Riaz, Humayun Bashir, Hassan Iqbal, Arif Jamshed, Ahmad Murtaza, Raza Hussain
BACKGROUND: Overview of clinical impact of positron emission tomography-computed tomography (PET-CT) scans in patients with head and neck carcinomas at our center. METHODS: Retrospective review of posttreatment (18)F-fluorodeoxyglucose ((18)F-FDG) PET-CT scans in patients with head and neck carcinomas with risk of residual disease. Clinical outcome served as the reference standard. RESULTS: This study included 93 patients (65.6% males, mean age: 48...
April 2017: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/28700454/posterior-only-hemivertebra-resection-for-congenital-cervicothoracic-scoliosis-correcting-neck-tilt-and-balancing-the-shoulders
#6
Zhonghui Chen, Yong Qiu, Zezhang Zhu, Song Li, Xi Chen, Liang Xu, Xu Sun
STUDY DESIGN: A retrospective study. OBJECTIVE: To evaluate radiographic and cosmetic outcomes following posterior-only cervicothoracic hemivertebra resection and instrumentation. SUMMARY OF BACKGROUND DATA: Cervicothoracic hemivertebra is a rare congenital deformity. It locates between the mobile cervical spine and the fixed thoracic spine, leading to rapid curve progression, shoulder imbalance, fixed torticollis and facial asymmetry. METHODS: This study reviewed a consecutive series of 18 patients with cervicothoracic hemivertebra...
July 11, 2017: Spine
https://www.readbyqxmd.com/read/28694425/insight-into-microtubule-disassembly-by-kinesin-13s-from-the-structure-of-kif2c-bound-to-tubulin
#7
Weiyi Wang, Soraya Cantos-Fernandes, Yuncong Lv, Hureshitanmu Kuerban, Shoeb Ahmad, Chunguang Wang, Benoît Gigant
Kinesin-13s are critical microtubule regulators which induce microtubule disassembly in an ATP dependent manner. To clarify their mechanism, we report here the crystal structure of a functional construct of the kinesin-13 Kif2C/MCAK in an ATP-like state and bound to the αβ-tubulin heterodimer, a complex mimicking the species that dissociates from microtubule ends during catalytic disassembly. Our results picture how Kif2C stabilizes a curved tubulin conformation. The Kif2C α4-L12-α5 region undergoes a remarkable 25° rotation upon tubulin binding to target the αβ-tubulin hinge...
July 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28689879/nonstandard-lumbar-region-in-predicting-fracture-risk
#8
Dima Alajlouni, Dana Bliuc, Thach Tran, Nicholas Pocock, Tuan V Nguyen, John A Eisman, Jacqueline R Center
Femoral neck (FN) bone mineral density (BMD) is the most commonly used skeletal site to estimate fracture risk. The role of lumbar spine (LS) BMD in fracture risk prediction is less clear due to osteophytes that spuriously increase LS BMD, particularly at lower levels. The aim of this study was to compare fracture predictive ability of upper L1-L2 BMD with standard L2-L4 BMD and assess whether the addition of either LS site could improve fracture prediction over FN BMD. This study comprised a prospective cohort of 3016 women and men over 60 yr from the Dubbo Osteoporosis Epidemiology Study followed up for occurrence of minimal trauma fractures from 1989 to 2014...
July 6, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28689482/a-semiautomated-method-for-measuring-the-3-dimensional-fabric-to-renal-artery-distances-to-determine-endograft-position-after-endovascular-aneurysm-repair
#9
Richte C L Schuurmann, Simon P Overeem, Kenneth Ouriel, Cornelis H Slump, William D Jordan, Bart E Muhs, Jean-Paul P M de Vries
PURPOSE: To report a methodology for 3-dimensional (3D) assessment of the stent-graft deployment accuracy after endovascular aneurysm repair (EVAR). METHODS: A methodology was developed and validated to calculate the 3D distances between the endograft fabric and the renal arteries over the curve of the aorta. The shortest distance between one of the renal arteries and the fabric (SFD) and the distance from the contralateral renal artery to the fabric (CFD) were determined on the first postoperative computed tomography (CT) scan of 81 elective EVAR patients...
July 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28689395/prognostic-factor-analysis-for-management-of-chronic-neck-pain-can-we-predict-the-severity-of-neck-pain-with-lateral-cervical-curvature
#10
Han Yu Seong, Moon Kyu Lee, Sang Ryong Jeon, Sung Woo Roh, Seung Chul Rhim, Jin Hoon Park
OBJECTIVE: Although little is known about its origins, neck pain may be related to several associated anatomical pathologies. We aimed to characterize the incidence and features of chronic neck pain and analyze the relationship between neck pain severity and its affecting factors. METHODS: Between March 2012 and July 2013, we studied 216 patients with chronic neck pain. Initially, combined tramadol (37.5 mg) plus acetaminophen (325 mg) was administered orally twice daily (b...
July 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28688933/defining-optimal-calcar-screw-positioning-in-proximal-humerus-fracture-fixation
#11
Eric M Padegimas, Benjamin Zmistowski, Cassandra Lawrence, Aaron Palmquist, Thema A Nicholson, Surena Namdari
BACKGROUND: Anatomic reduction and placement of an inferior calcar screw are strategies to prevent fixation failure in proximal humerus factures. Optimal position of the calcar screw remains unknown. METHODS: There were 168 shoulders (68.5% female; average age, 63.6 ± 11.5 years) that underwent open reduction and internal fixation of a displaced proximal humerus fracture involving the surgical or anatomic neck. Univariate and multivariate analyses were performed on preoperative clinical, preoperative radiographic, and postoperative radiographic variables to determine association with fixation failure...
July 5, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28688683/predictive-and-prognostic-value-of-ct-based-radiomics-signature-in-locally-advanced-head-and-neck-cancers-patients-treated-with-concurrent-chemoradiotherapy-or-bioradiotherapy-and-its-added-value-to-human-papillomavirus-status
#12
Dan Ou, Pierre Blanchard, Silvia Rosellini, Antonin Levy, France Nguyen, Ralph T H Leijenaar, Ingrid Garberis, Philippe Gorphe, François Bidault, Charles Ferté, Charlotte Robert, Odile Casiraghi, Jean-Yves Scoazec, Philippe Lambin, Stephane Temam, Eric Deutsch, Yungan Tao
OBJECTIVES: To explore prognostic and predictive value of radiomics in patients with locally advanced head and neck squamous cell carcinomas (LAHNSCC) treated with concurrent chemoradiotherapy (CRT) or bioradiotherapy (BRT). MATERIALS AND METHODS: Data of 120 patients (CRT vs. BRT matched 2:1) were retrospectively analyzed. A total of 544 radiomics features of the primary tumor were extracted from radiotherapy planning computed tomography scans. Cox proportional hazards models were used to examine the association between survival and radiomics features with false discovery rate correction...
August 2017: Oral Oncology
https://www.readbyqxmd.com/read/28673060/urethral-closure-pressure-at-stress-a-predictive-measure-for-the-diagnosis-and-severity-of-urinary-incontinence-in-women
#13
Anne-Cécile Pizzoferrato, Arnaud Fauconnier, Xavier Fritel, Georges Bader, Philippe Dompeyre
PURPOSE: Maintaining urinary continence at stress requires a competent urethral sphincter and good suburethral support. Sphincter competence is estimated by measuring the maximal urethral closure pressure at rest. We aimed to study the value of a new urodynamic measure, the urethral closure pressure at stress (s-UCP), in the diagnosis and severity of female stress urinary incontinence (SUI). METHODS: A total of 400 women without neurological disorders were included in this observational study...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28671055/silencing-of-long-non-coding-rna-ccat2-depressed-malignancy-of-oral-squamous-cell-carcinoma-via-wnt-%C3%AE-catenin-pathway
#14
Yuji Ma, Xuanhao Hu, Chao Shang, Ming Zhong, Yan Guo
Oral squamous cell carcinoma is a common and lethal malignancy affecting the head and neck region. CCAT2 (colon cancer-associated transcript 2) gene is affiliated with long non-coding RNAs, which are often found to have important regulatory roles in cancers. This study aims to assess the expression and clinical significance of CCAT2 gene, identify its malignant biological behaviors, and explore the possible mechanisms in oral squamous cell carcinoma. CCAT2 expression was detected by quantitative real-time polymerase chain reaction, and its relationship with clinical factors was assayed using the Kaplan-Meier survival curve...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28671052/prognostic-value-of-primary-gross-tumor-volume-and-standardized-uptake-value-of-18-f-fdg-in-pet-ct-for-distant-metastasis-in-locoregionally-advanced-nasopharyngeal-carcinoma
#15
Ya-Nan Jin, Ji-Jin Yao, Si-Yang Wang, Wang-Jian Zhang, Guan-Qun Zhou, Fan Zhang, Zhi-Bin Cheng, Jun Ma, Hao-Yuan Mo, Ying Sun
Distant metastasis has become the predominant model of treatment failures in patients with locoregionally advanced nasopharyngeal carcinoma. Effort should therefore be made to stratify locoregionally advanced nasopharyngeal carcinoma patients into different groups based on the risk of metastasis to improve prognosis and tailor individualized treatments. This study aims to assess the value of primary gross tumor volume and the maximum standardized uptake value for predicting distant metastasis-free survival of patients with locoregionally advanced nasopharyngeal carcinoma...
July 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28667590/using-nonlinear-finite-element-models-to-analyse-stress-distribution-during-subluxation-and-torque-required-for-dislocation-of-newly-developed-total-hip-structure-after-prosthetic-impingement
#16
Wei-Min Chi, Chien-Chung Lin, Ying-Jui Ho, Hsiao-Che Lin, Jian-Horng Chen
Dislocation is a serious potential complication of total hip replacement. Previous studies have proposed a newly developed total hip structure that meets the required oscillation angle of 120°, for which the chamfer on the acetabular liner rim was designed to enable the neck to impinge on the chamfer over a large area after impingement occurs. This study adopted the finite element method to further analyse the torque limits leading to dislocation and the contact stresses at the impingement and egress sites of the liner during subluxation...
July 1, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28665458/a-robotic-needle-driver-to-facilitate-vescico-urethral-anastomosis-during-laparoscopic-radical-prostatectomy
#17
Virginia Varca, Andrea Benelli, Francesco Pietrantuono, Nazareno Suardi, Andrea Gregori, Franco Gaboardi
PURPOSE: The completion of the vescico-urethral anastomosis (VUA) represents the most critical step of laparoscopic radical prostatectomy (LRP), and it can often discourage the use of minimally invasive surgery in less experienced laparoscopic surgeons. The aim of this paper is to evaluate the usefulness of a new robotic needle driver named Dextérité in performing the VUA after LRP. MATERIALS AND METHODS: This prospective randomized clinical study enrolled 40 consecutive patients eligible for LRP, which were randomized into four groups: group A, patients undergoing LRP done by an expert surgeon; group B, patients undergoing robotic-assisted radical prostatectomy (RARP) performed by the same expert surgeon; group C, patients undergoing LRP performed by a young surgeon at the beginning of the learning curve; group D, patients undergoing LRP performed by another young surgeon at the beginning of the learning curve with the aid of Dextérité needle driver for completion of the VUA...
June 19, 2017: Urologia
https://www.readbyqxmd.com/read/28659184/rerg-suppresses-cell-proliferation-migration-and-angiogenesis-through-erk-nf-%C3%AE%C2%BAb-signaling-pathway-in-nasopharyngeal-carcinoma
#18
Weilin Zhao, Ning Ma, Shumin Wang, Yingxi Mo, Zhe Zhang, Guangwu Huang, Kaoru Midorikawa, Yusuke Hiraku, Shinji Oikawa, Mariko Murata, Kazuhiko Takeuchi
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck that is prevalent in Southeast Asia and southern China. Recent studies in epigenetics suggest that DNA methylation plays a pivotal role in the onset and progression of cancer. Combining the methyl-DNA binding domain capture technique and cDNA microarray analysis, we identified a unique hypermethylated gene, RERG (Ras-like estrogen-regulated growth inhibitor), that was down-regulated in NPC tissues. RERG is a tumor suppressor gene that was first reported in breast cancer...
June 28, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28658890/chemoresponse-assay-in-head-and-neck-cancer-patients-a-three-year-follow-up
#19
Basem T Jamal, Gregory A Grillone, Scharukh Jalisi
INTRODUCTION: The majority of patients with advanced head and neck cancer receiving chemotherapy show partial response or frank resistance. Therefore, assessing the individuals' tumour reactivity to the eligible chemotherapeutic compounds carries the potential of personalizing the patient treatment and minimizing ineffective regimens which lead to excess toxicity and cost, treatment delays and possibly causing the tumour to be cross resistant to additional drugs. AIM: To determine the effectiveness of a phenotypic chemoresponse assay in predicting response to chemotherapy in a retrospective series of head and neck cancer patients whose tumour specimens had been tested with ChemoFx assay (Precision Theraputic Inc...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28658110/the-clinical-outcome-correlations-between-radiation-dose-and-pretreatment-metabolic-tumor-volume-for-radiotherapy-in-head-and-neck-cancer-a-retrospective-analysis
#20
Shih-Neng Yang, Yu-Rou Chiou, Geoffrey G Zhang, Kuei-Ting Chou, Tzung-Chi Huang
This study was to investigate the clinical outcomes between radiation dose and pretreatment metabolic tumor volume (MTV) in patients with head and neck cancer treated with definitive chemoradiotherapy.Thirty-four patients received pretreatment F-fluorodeoxyglucose (F-FDG) positron emission tomography-computed tomography (PET/CT) were recruited for this study. The CT-based volume (gross tumor volume of the primary [GTVp]) and 4 types of MTVs were measured on the basis of either a maximal standardized uptake value (SUVmax) of 2...
June 2017: Medicine (Baltimore)
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