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Stroke reperfusion injury

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https://www.readbyqxmd.com/read/30221657/huwe1-is-a-novel-mediator-of-protection-of-neural-progenitor-l2-3-cells-against-oxygen%C3%A2-glucose-deprivation-injury
#1
Xiaoqin Jiang, Jiyun Yang, Hedong Li, Yi Qu, Wenming Xu, Haiyan Yu, Yu Tong
Hypoxic‑ischemic encephalopathy is one of the most notable causes of brain injury in newborns. Cerebral ischemia and reperfusion lead to neuronal damage and neurological disability. In vitro and in vivo analyses have indicated that E3 ubiquitin protein ligase (Huwe1) is important for the process of neurogenesis during brain development; however, the exact biological function and the underlying mechanism of Huwe1 remain controversial. In the present study, neural progenitor cells, L2.3, of which we previously generated from rat E14...
September 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30219993/uric-acid-treatment-after-stroke-prevents-long-term-middle-cerebral-artery-remodelling-and-attenuates-brain-damage-in-spontaneously-hypertensive-rats
#2
Elena Jiménez-Xarrié, Belén Pérez, Ana Paula Dantas, Lídia Puertas-Umbert, Joan Martí-Fabregas, Ángel Chamorro, Anna Maria Planas, Elisabet Vila, Francesc Jiménez-Altayó
Hypertension is the most important modifiable risk factor for stroke and is associated with poorer post-stroke outcomes. The antioxidant uric acid is protective in experimental normotensive ischaemic stroke. However, it is unknown whether this treatment exerts long-term protection in hypertension. We aimed to evaluate the impact of transient intraluminal middle cerebral artery (MCA) occlusion (90 min)/reperfusion (1-15 days) on brain and vascular damage progression in adult male Wistar-Kyoto (WKY; n = 36) and spontaneously hypertensive (SHR; n = 37) rats treated (i...
September 15, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/30218809/bu-yang-huan-wu-decoction-prevents-reperfusion-injury-following-ischemic-stroke-in-rats-via-inhibition-of-hif-1-%C3%AE-vegf-and-promotion-%C3%AE-enac-expression
#3
Zhen-Zhen Chen, Xin Gong, Qi Guo, Hui Zhao, Lei Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Bu Yang Huan Wu Decoction (BYHW) is a famous traditional Chinese medicine (TCM) formula used in China for the treatment of cerebral ischemic stroke. But the protective effects and underlining mechanisms of BYHW remain unclear. AIM OF THE STUDY: This study was designed to investigate the protective effects and underlining signaling mechanisms of BYHW on brain tissues in a rat model of cerebral ischemic reperfusion (I/R) injury. MATERIALS AND METHODS: Liquid chromatography was used to verify the composition of BYHW...
September 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30213662/muscle-derived-autologous-mitochondrial-transplantation-a-novel-strategy-for-treating-cerebral-ischemic-injury
#4
Zhanqin Zhang, Zhi Ma, Chaoying Yan, Kairui Pu, Meiyan Wu, Juan Bai, Yansong Li, Qiang Wang
The available evidence showed that mitochondrial transfer by releasing the extracellular vesicles containing mitochondria from astrocytes to neurons exerted a neuroprotective effect after stroke. Whether extracellular mitochondrial replenishment could rescue the tissues from cerebral ischemic injury still needs to be explored completely. It was hypothesized that the augmentation of mitochondrial damage after cerebral ischemia could be resolved by timely replenishment of exogenous mitochondria. A stroke model of middle cerebral artery occlusion (MCAO) was used in this study to verify this hypothesis...
September 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/30199348/targeted-temperature-management-peltier-s-element-based-focal-brain-cooling-protects-penumbra-neurons-from-progressive-damage-in-experimental-cerebral-ischemia
#5
Miyuki Tauchi, Maria Mercedes Tejada de Rink, Hiroshi Fujioka, Satoko Okayama, Kei-Ichiro Nakamura, Barbara Dietel, Stephan Achenbach, Rainer Kollmar, Stefan Schwab, Kazuo Ushijima, Hideki Harada
Targeted temperature management (TTM), or therapeutic hypothermia, is one of the most potent neuroprotective approaches after ischemic and traumatic brain injuries. TTM has been applied clinically with various methods, but effective achievement and maintenance of the target temperature remain challenging. Furthermore, timing of cooling and target body and brain temperature to optimize effectiveness for neuroprotection and to minimize side effects are yet to be standardized. Focal brain cooling is a potential strategy to minimize adverse effects of systemic TTM...
September 8, 2018: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/30197059/chrysophanol-attenuates-nitrosative-oxidative-stress-injury-in-a-mouse-model-of-focal-cerebral-ischemia-reperfusion
#6
Yongmei Zhao, Yuyou Huang, Yalan Fang, Haiping Zhao, Wenjuan Shi, Jincheng Li, Yunxia Duan, Yuwei Sun, Li Gao, Yumin Luo
Nitrosative/oxidative stress plays an important role in neuronal death following cerebral ischemia/reperfusion (I/R). Chrysophanol (CHR) has been shown to afford significant neuroprotection on ischemic stroke, however, whether its mechanism is related to attenuating nitrosative/oxidative stress is not clear. In the present study, we investigated the effect of CHR on neuronal injury related to nitric oxide (NO) production by using mouse middle cerebral artery occlusion (MCAO) model. Our results revealed that nitrite plus nitrate (NOx - ) and 3-nitrotyrosine (3-NT) levels increased in ischemic brain 14 days after reperfusion, and were subsequently attenuated by CHR treatment...
August 25, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/30196826/oxymatrine-attenuates-cognitive-deficits-through-sirt1-mediated-autophagy-in-ischemic-stroke
#7
Shuhu Zhou, Baojun Qiao, Xu Chu, Qingxia Kong
To investigate if oxymatrine could ameliorate hippocampus ischemia/reperfusion (I/R) injury induced in rats and explore the possible mechanism. Rats were randomly divided into four groups: sham group, I/R group, I/R + OMT-treated group, I/R + Vehicle-treated group. Oxymatrine or vehicle solution was intraperitoneally injected OMT (150 mg/kg) 60 min before renal ischemia respectively. Water maze was measured; cell apoptosis was assessed by doing TUNEL assay and detecting the expression of P53, Bax, and Cleaved-Caspase-3; autophagy were assessed by measuring the expression of LC3 and P62...
October 15, 2018: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/30191760/a-new-era-for-stroke-therapy-integrating-neurovascular-protection-with-optimal-reperfusion
#8
Ligen Shi, Marcelo Rocha, Rehana K Leak, Jingyan Zhao, Tarun N Bhatia, Hongfeng Mu, Zhishuo Wei, Fang Yu, Susan L Weiner, Feifei Ma, Tudor G Jovin, Jun Chen
Recent advances in stroke reperfusion therapies have led to remarkable improvement in clinical outcomes, but many patients remain severely disabled, due in part to the lack of effective neuroprotective strategies. In this review, we show that 95% of published preclinical studies on "neuroprotectants" (1990-2018) reported positive outcomes in animal models of ischemic stroke, while none translated to successful Phase III trials. There are many complex reasons for this failure in translational research, including that the majority of clinical trials did not test early delivery of neuroprotectants in combination with successful reperfusion...
September 7, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30188259/factors-that-may-contribute-to-poor-outcome-despite-good-reperfusion-after-acute-endovascular-stroke-therapy
#9
Alejandro A Rabinstein, Gregory W Albers, Waleed Brinjikji, Sebastian Koch
Endovascular therapy with mechanical thrombectomy is a formidable treatment for severe acute ischemic stroke caused by occlusion of a proximal intracranial artery. Its strong beneficial effect is explained by the high rates of very good and excellent reperfusion achieved with current endovascular techniques. However, there is a sizable proportion of patients who do not experience clinical improvement despite successful recanalization of the occluded artery and reperfusion of the ischemic territory. Factors such as baseline reserve, collateral flow, anesthesia and systemic factors have been identified as potential culprits for lack of improvement in the setting of timely and successful revascularization...
September 6, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/30186497/activation-of-epha4-induced-by-ephrina1-exacerbates-disruption-of-the-blood-brain-barrier-following-cerebral-ischemia-reperfusion-via-the-rho-rock-signaling-pathway
#10
Fangbin Chen, Zhiyang Liu, Wei Peng, Zhiqin Gao, Hui Ouyang, Tongjun Yan, Songbai Ding, Zhankui Cai, Bin Zhao, Longjin Mao, Zhiyong Cao
Vascular dementia (VD) is a syndrome characterized by progressive cognitive decline. According to previous studies, stroke is considered to be a risk factor for VD. The disruption of the blood-brain barrier (BBB) is pivotal to the pathology of stroke, as it contributes to post-stroke inflammation and edema. It has been reported that the Eph/Ephrin signaling pathway serves an important role in central nervous system injury. However, the role of EphrinA1/EphA4 signaling in BBB damage following ischemic stroke has not yet been reported...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30186462/morroniside-protects-against-cerebral-ischemia-reperfusion-injury-by-inhibiting-neuron-apoptosis-and-mmp2-9-expression
#11
Guoyong Zeng, Weijiang Ding, Yin Li, Meiying Sun, Liying Deng
The aim of the present study was to investigate the effect of morroniside against matrix metalloproteinase (MMP)2/9 and focal cerebral ischemia/reperfusion (I/R) injury in rats. A rat model of focal cerebral I/R injury rats was established and rats were administered with 30, 90 or 270 mg/kg/day morroniside for 7 days. The expression of MMP2/9 and neuronal apoptosis were assessed. In addition, the expression of active caspase-3, B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax) were measured. The results revealed that MMP2 and MMP9 expression was upregulated and the percentage of apoptotic neurons was increased in rats with focal cerebral I/R injury compared with the control...
September 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/30181779/ischemia-reperfusion-injury-in-stroke-impact-of-the-brain-barriers-and-brain-immune-privilege-on-neutrophil-function
#12
REVIEW
Gaby Enzmann, Soghra Kargaran, Britta Engelhardt
Reperfusion injury following ischemic stroke is a complex pathophysiological process involving numerous mechanisms ranging from the release of excitatory amino acids and ion disequilibrium to the induction of apoptosis and necrosis, to oxidative stress and inflammation. The migration of neutrophils into the brain parenchyma and release of their abundant proteases are generally considered the main cause of neuronal cell death and acute reperfusion injury following ischemic stroke. Recent findings in experimental and human stroke have challenged this view, as the majority of neutrophils were rather found to accumulate within the neurovascular unit (NVU) and the subarachnoid space (SAS) where they remain separated from the brain parenchyma by the glia limitans ...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/30174499/plumbagin-inhibits-neuronal-apoptosis-intimal-hyperplasia-and-also-suppresses-tnf-%C3%AE-nf-%C3%AE%C2%BAb-pathway-induced-inflammation-and-matrix-metalloproteinase-2-9-expression-in-rat-cerebral-ischemia
#13
Xiao-Juan Chen, Jian-Guo Zhang, Lan Wu
Cerebral ischemic damage and infarction are well documented in stroke, which is presenting a foremost health concern globally with very high mortality and morbidity rates. Mechanisms that are associated with excitotoxicity, inflammation and oxidative stress are found to be critically involved in ischemic damage. Adverse effects of current therapies are imposing the need in development of neuroprotective agents that are very effective. To explore this we experimentally induced ischemic brain injury and investigated the effects of plumbagin...
September 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/30172704/apoptosis-signal-regulating-kinase-1-silencing-on-astroglial-inflammasomes-in-an-experimental-model-of-ischemic-stroke
#14
So Yeong Cheon, Eun Jung Kim, So Yeon Kim, Jeong Min Kim, Eun Hee Kam, Jong-Kwang Park, Bon-Nyeo Koo
Activation of the inflammasome complex contributes to the inflammatory response and cell death under pathologic conditions. The nucleotide-binding oligomerization domain-like receptor pyrin domain-containing 2 (NLRP2) inflammasome is activated in astrocytes after cerebral ischemia, which can aggravate ischemic damage. Apoptosis signal-regulating kinase 1 (ASK1) is an early activator and immune-regulator after ischemic injury, that can lead to cell death. The objective of the present study was to evaluate the role of ASK1 in controlling NLRP2 inflammasomes in astrocytes after cerebral ischemia...
August 31, 2018: Neuroscience
https://www.readbyqxmd.com/read/30171935/tetramethylpyrazine%C3%A2-2-o%C3%A2-sodium-ferulate-provides-neuroprotection-against-neuroinflammation-and-brain-injury-in-mcao-r-rats-by-suppressing-tlr-4-nf-%C3%AE%C2%BAb-signaling-pathway
#15
Peipei Zhou, Shuzhang Du, Lin Zhou, Zhi Sun, Li Hua Zhuo, Guangwei He, Yan Zhao, Yulin Wu, Xiaojian Zhang
BACKGROUND: Neuroinflammation following cerebral ischemia is a serious risk factor in stroke patients. The purpose of this study was to investigate the neuroprotective effects of tetramethylpyrazine‑2'O‑sodium ferulate (TSF), a structurally modified compound from tetramethylpyrazine and ferulate, on cerebral ischemic injury and the underlying mechanisms. METHODS: Focal transient cerebral ischemia was induced in rat for 2 h by middle cerebral artery occlusion (MCAO) and the protective effect of TSF was studied using different doses of the drug (10...
August 29, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/30168601/z-guggulsterone-attenuates-astrocytes-mediated-neuroinflammation-after-ischemia-by-inhibiting-toll-like-receptor-4-pathway
#16
Tianlong Liu, Minna Liu, Tiejun Zhang, Wenxing Liu, Hang Xu, Fei Mu, Danjun Ren, Na Jia, Zhengjun Li, Yi Ding, Aidong Wen, Yuwen Li
Inflammatory damage plays a pivotal role in ischemic stroke pathogenesis and may represent one of the therapeutic targets. Z-Guggulsterone (Z-GS), an active component derived from myrrh, has been used to treat various diseases. The traditional uses suggest that myrrh is a good candidate for anti-inflammatory damage. The present study was to investigate the anti-inflammatory and neuroprotective effects of Z-GS following cerebral ischemic injury, as well as the exact mechanisms behind them. Rat middle cerebral artery occlusion (MCAO) model and in vitro astrocytes oxygen-glucose deprivation (OGD) model were adopted to simulate ischemic stroke...
August 31, 2018: Journal of Neurochemistry
https://www.readbyqxmd.com/read/30158991/xingnaojing-injection-protects-against-cerebral-ischemia-reperfusion-injury-via-pi3k-akt-mediated-enos-phosphorylation
#17
Yue-Ming Zhang, Xiao-Yu Qu, Jing-Hui Zhai, Li-Na Tao, Huan Gao, Yan-Qing Song, Si-Xi Zhang
Xingnaojing (XNJ) injection, derived from traditional Chinese medicine formulation, has a protective effect against stroke, but the underlying mechanism is unclear, which severely limited its clinical application. This research aims to elucidate the role and mechanism of XNJ in reducing cerebral ischemic reperfusion (I/R) injury. Rats received 2 h cerebral ischemia followed by reperfusion of 24 h and were intraperitoneally given 5, 10, or 15 ml/kg XNJ 24 h before ischemia and at the onset of reperfusion, respectively...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30152713/comparative-transcriptome-of-neurons-after-oxygen-glucose-deprivation-potential-differences-in-neuroprotection-versus-reperfusion
#18
Shuzhen Guo, Anna Tjärnlund-Wolf, Wenjun Deng, Emiri Tejima-Mandeville, Lauren J Lo, Changhong Xing, Ken Arai, MingMing Ning, Yiming Zhou, Eng H Lo
In the context of ischemic stroke, rescuing neurons can be theoretically achieved with either reperfusion or neuroprotection. Reperfusion works via the rapid restoration of oxygen and glucose delivery. Neuroprotection comprises molecular strategies that seek to block excitotoxicity, oxidative stress or various cell death pathways. Here, we propose the hypothesis that neurons rescued with reperfusion are different from neurons rescued with molecular neuroprotection. Neurons were subjected to oxygen-glucose deprivation (OGD) and then treated with "in vitro reperfusion" (i...
August 28, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/30151417/impact-of-dental-pulp-stem-cells-overexpressing-hepatocyte-growth-factor-after-cerebral-ischemia-reperfusion-in-rats
#19
Kota Sowa, Chikako Nito, Masataka Nakajima, Satoshi Suda, Yasuhiro Nishiyama, Yuki Sakamoto, Yuko Nitahara-Kasahara, Aki Nakamura-Takahashi, Masayuki Ueda, Kazumi Kimura, Takashi Okada
Hepatocyte growth factor (HGF) has neuroprotective effects against ischemia-induced injuries. Dental pulp stem cell (DPSC) transplantation attenuates tissue injury in the brain of rats with post-transient middle cerebral artery occlusion. We sought to determine whether DPSCs that overexpress HGF can enhance their therapeutic effects on brain damage post-ischemia/reperfusion injury. Treatment with DPSCs overexpressing HGF reduced infarct volumes compared to unmodified DPSC treatment at 3 and 7 days post-transient middle cerebral artery occlusion...
September 21, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/30149915/microglia-trem2-is-required-for-electroacupuncture-to-attenuate-neuroinflammation-in-focal-cerebral-ischemia-reperfusion-rats
#20
Hongbei Xu, Song Mu, Wenyi Qin
Neuroinflammation plays a critical role in ischemic stroke pathology and could be a promising target in ischemic stroke. Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglia-specific receptor in the CNS that is involved in regulating neuroinflammation in cerebral ischemia. However, the role of TREM2 in ischemic stroke is controversial. Electroacupuncture (EA) is an effective therapy for alleviating stroke-induced neuroinflammation. Here, we found that ischemic stroke induced an increased microglial TREM2 expression, and EA treatment can further promote microglial TREM2 expression following cerebral ischemia...
September 18, 2018: Biochemical and Biophysical Research Communications
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