Sana Mahtab, Zachary J Madewell, Shabir A Madhi, Amy Wise, Peter J Swart, Sithembiso Velaphi, Inacio Mandomando, Justina Bramugy, Rita Mabunda, Elisio Xerinda, Anthony G Scott, Nega Assefa, Lola Madrid, Mulu Bweihun, Fikremelekot Temesgen, Dickens Onyango, Victor Akelo, Richard Oliech, Peter Otieno, Jennifer R Verani, Shams El Arifeen, Emily S Gurley, Muntasir Alam, Afruna Rahman, Mohammad Zahid Hossain, Samba Sow, Karen Kotloff, Milagritos Tapia, Adama Mamby Keita, Doh Sanogo, Ikechukwu Ogbuanu, Julius Ojulong, Sandra Lako, Okokon Ita, Erick Kaluma, Tais Wilson, Portia Mutevedzi, Beth A Tippett Barr, Cynthia G Whitney, Dianna M Blau, Quique Bassat
BACKGROUND: Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and is also associated with stillbirth. This study aimed to determine the proportion of stillborn infants and infants who died between 0 and 90 days attributable to GBS using postmortem minimally invasive tissue sampling (MITS) in 7 low- and middle-income countries (LMICs) participating in Child Health and Mortality Prevention Surveillance (CHAMPS). METHODS: Deaths that occurred between December 2016 and December 2021 were investigated with MITS, including culture for bacteria of blood and cerebrospinal fluid (CSF), multipathogen polymerase chain reaction on blood, CSF, and lung tissue and histopathology of lung, liver, and brain...
September 2023: Open Forum Infectious Diseases