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https://www.readbyqxmd.com/read/30428879/croton-gratissimus-leaf-extracts-inhibit-cancer-cell-growth-by-inducing-caspase-3-7-activation-with-additional-anti-inflammatory-and-antioxidant-activities
#1
Emmanuel Mfotie Njoya, Jacobus N Eloff, Lyndy J McGaw
BACKGROUND: Croton species (Euphorbiaceae) are distributed in different parts of the world, and are used in traditional medicine to treat various ailments including cancer, inflammation, parasitic infections and oxidative stress related diseases. The present study aimed to evaluate the antioxidant, anti-inflammatory and cytotoxic properties of different extracts from three Croton species. METHODS: Acetone, ethanol and water leaf extracts from C. gratissimus, C. pseudopulchellus, and C...
November 14, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/30423731/designing-heparan-sulfate-based-biocompatible-polymers-and-their-application-for-intracellular-stimuli-sensitive-drug-delivery
#2
Lipeng Qiu, Lu Ge, Miaomiao Long, Qian Wang, Yan Zhang, Xiaotian Shan, Jingxiao Chen, Huijie Zhang, Xiaomei Li, Guozhong Lv, Jinghua Chen
Heparan sulfate (HS) is a kind of natural polysaccharides with good biocompatibility. And as drug carriers, it has some advantages compared to heparin. However, the preparation of HS is cumbersome and difficult, which limits its application in drug delivery. Here, we use modern separation technique combined with chromatography to establish a new preparation method of HS. The molecular weight and degree of dispersion of HS were (1.03 × 104  ± 107) kDa and 1.106, respectively. HS also showed low anticoagulation activity in comparison with heparin...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/30406584/performances-of-pichia-kudriavzevii-in-decolorization-biodegradation-and-detoxification-of-c-i-basic-blue-41-under-optimized-cultural-conditions
#3
Crăița Maria Roșu, Gabriela Vochița, Marius Mihășan, Mihaela Avădanei, Cosmin Teodor Mihai, Daniela Gherghel
The aim of this study was to evaluate the performances of Pichia kudriavzevii CR-Y103 yeast strain for the decolorization, biodegradation, and detoxification of cationic dye C.I. Basic Blue 41, a toxic compound to aquatic life with long-lasting effects. Under optimized cultural conditions (10.0-g L-1 glucose, 0.2-g L-1 yeast extract, and 1.0-g L-1 (NH4 )2 SO4 ), the yeast strain was able to decolorize 97.86% of BB41 (50 mg L-1 ) at pH 6 within 4 h of incubation at 30 °C under shaken conditions (12,238...
November 7, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/30401409/presence-of-pig-igg-and-igm-in-sera-samples-from-baboons-after-an-orthotopic-liver-xenotransplantation
#4
G Ramis, L Martínez-Alarcón, E Medina-Moreno, J M Abellaneda, J J Quereda, B Febrero, A Sáez-Acosta, A Ríos, A Muñoz, P Ramírez, M J Majado
INTRODUCTION: The immunorejection in xenotransplantation has mostly been studied from the host's immune system activation point of view and there is very little information about the graft-vs-host reaction. OBJECTIVES: To validate an enzyme-linked immunosorbent assay (ELISA) test for porcine IgM and IgG quantitation, the assessment of porcine IgG and IgM in sera samples from baboons after liver orthotopic xenotransplantation or in human plasma after xenotransfusion through pig organs, and to assess the presence of porcine immunoglobulin in a baboon after plasmapheresis to a complete change of plasma after 4 passages through pig liver...
November 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/30380833/amyloid-like-structures-formed-by-single-amino-acid-self-assemblies-of-cysteine-and-methionine
#5
Nidhi Gour, Chandra Kanth P, Bharti Koshti, Vivekshinh Kshtriya, Dhruvi Shah, Sunita Patel, Reena Agrawal-Rajput, Manoj Kumar Pandey
We report for the very first time the discovery of amyloid like self-assemblies formed by the non-aromatic single amino acids Cysteine (Cys) and Methionine (Met) under neutral aqueous conditions. The structure formation was assessed and characterized by various microscopic and spectroscopic techniques such as optical microscopy, phase contrast microscopy, scanning electron microscopy and transmission electron microscopy. The mechanism of self-assembly and the role of hydrogen bonding and thiol interactions of Cys and Met were assessed by FTIR, TGA, XRD and solid state NMR along with various control experiments...
November 1, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30366286/synthesis-docking-admet-prediction-cytotoxicity-and-antimicrobial-activity-of-oxathiadiazole-derivatives
#6
Madhu Yadav, Ritika Srivastava, Farha Naaz, Ramendra K Singh
A series of molecules bearing oxathiadiazole, a five membered heterocyclic ring has been designed, synthesized and screened for antimicrobial activity. Molecules, 1a, 1b, 1d, 3a-b and 4a-b were found to be highly active (MIC value upto 1.5 μg/mL) against different human pathogens, namely S. aureus, B. cerus, P. aeruginosa and E. coli. Some of the compounds, 1a, 1b and 1d have also shown the antifungal activity (MIC value upto 6.2 μg/mL) against Candida albicans, Candida glubrate and Candida crusei. During in vitro cytotoxicity study, the oxathiadiazole derivatives showed less toxicity than the reference used against PBM, CEM and Vero (African green monkey kidney) cell lines...
October 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/30365115/novel-2-3%C3%A2-disubstituted-1-3%C3%A2-thiazolidin%C3%A2-4%C3%A2-one-derivatives-as-potential-antitumor-agents-in-renal-cell-adenocarcinoma
#7
Monika Gawrońska-Grzywacz, Łukasz Popiołek, Dorota Natorska-Chomicka, Iwona Piątkowska-Chmiel, Magdalena Izdebska, Mariola Herbet, Magdalena Iwan, Agnieszka Korga, Jarosław Dudka, Monika Wujec
Cancer represents one of the main causes of mortality in developed countries. In particular, the overall survival of patients with renal cell carcinoma (RCC) remains poor and the available cytostatic agents are insufficient. Therefore, there is an urgent requirement to identify more effective and safer anticancer drugs. Recently, the evaluation of antitumor activity appeared to be promising for thiazolidinone derivatives. The present study presents the synthesis and the cytotoxicity assays of 1,3‑thiazolidin‑4‑ones...
October 16, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30355685/low-ph-endocytic-entry-of-the-porcine-alphaherpesvirus-pseudorabies-virus
#8
Jonathan L Miller, Darin J Weed, Becky H Lee, Suzanne M Pritchard, Anthony V Nicola
The alphaherpesvirus pseudorabies virus (PRV) is the causative agent of pseudorabies, a disease of great economic and welfare importance in swine. Other alphaherpesviruses, including herpes simplex virus (HSV), utilize low pH-mediated endocytosis to enter a subset of cell types. We investigated whether PRV used this entry pathway in multiple laboratory model cell lines. Inhibition of receptor-mediated endocytosis by treatment with hypertonic medium prevented PRV entry. PRV entry into several cell lines including porcine kidney (PK15) cells, and African green monkey kidney (Vero) cells was inhibited by noncytotoxic concentrations of the lysosomotropic agents ammonium chloride or monensin, which block the acidification of endosomes...
October 24, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30347233/outbreak-of-toxoplasmosis-in-four-squirrel-monkeys-saimiri-sciureus-in-japan
#9
Maki Nishimura, Takashi Goyama, Sohei Tomikawa, Ragab M Fereig, El-Sayed N El-Alfy, Kisaburo Nagamune, Yoshiyasu Kobayashi, Yoshifumi Nishikawa
Toxoplasma gondii is a protozoan parasite that causes fatal disease in New World monkeys. Several reports have described outbreaks of toxoplasmosis in squirrel monkeys. Here, we report the death of four squirrel monkeys in a captive colony from acute toxoplasmosis, one of which developed toxoplasmosis about 1 year after the initial outbreak. Serum anti-T. gondii antibody was detected by a latex agglutination test in the animals, and one presented seropositive before clinical signs were observed. Macroscopically, the lungs were severely affected and three animals showed pulmonary edema...
October 19, 2018: Parasitology International
https://www.readbyqxmd.com/read/30277593/repeated-injection-of-kmrc011-a-medical-countermeasure-for-radiation-can-cause-adverse-health-effects-in-cynomolgus-monkeys
#10
Hong-Soo Lee, Yoo-Jin Park, Doo-Wan Cho, Su-Cheol Han, Soo Youn Jun, Gi Mo Jung, Woo-Jong Lee, Chi-Min Choi, Eun-Jung Park, Son-Il Pak
High-dose radiation-induced tissue damage is a major limiting factor in the medical application of nuclear technology. Herein, we tested 28-day repeated-dose toxicity of KMRC011, an agonist of toll-like receptor (TLR) 5, which is being developed as a medical countermeasure for radiation, using cynomolgus monkeys. KMRC011 (0.01, 0.02 or 0.04 mg/kg/day) was intramuscularly injected once daily for 4 weeks, and each two monkeys in both control and 0.04 mg/kg/day group were observed for an additional 2-week recovery period...
September 11, 2018: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/30250991/whole-body-pet-imaging-with-a-norepinephrine-transporter-probe-4-18-f-fluorobenzylguanidine-biodistribution-and-radiation-dosimetry
#11
Stephen J Lokitz, Sudha Garg, Rachid Nazih, Pradeep K Garg
PURPOSE: 4-[18 F]Fluorobenzylguanidine ([18 F]PFBG) is a positron emission tomography (PET) probe for non-invasive targeting of the norepinephrine transporter. The aim of this study was to assess uptake and distribution characteristics of this PET probe. PROCEDURES: Three cynomolgus monkeys were injected with 269 ± 51 MBq (7.3 ± 1.4 mCi) of [18 F]PFBG and 21 whole body PET scans were acquired over 165 min. s around organs to generate time-activity curves...
September 24, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/30231617/exploring-the-anomalous-cytotoxicity-of-commercially-available-poly-n-isopropyl-acrylamide-substrates
#12
Phuong A H Nguyen, Lyndsay Stapleton, Adrian Ledesma-Mendoza, Darnell L Cuylear, Marta A Cooperstein, Heather E Canavan
Poly( N -isopropyl acrylamide) (pNIPAM) is a stimulus-responsive polymer that has been of great interest to the bioengineering community. When the temperature is lowered below its lower critical solution temperature (∼32 °C), pNIPAM rapidly hydrates, and adherent cells detach as intact cell sheets. This cell-releasing behavior in a physiologically relevant temperature range has led to NIPAM's use for engineered tissues and other devices. In a previous study, however, the authors found that although most techniques used to polymerize NIPAM yield biocompatible films, some formulations from commercially-available NIPAM (cpNIPAM) can be cytotoxic...
September 19, 2018: Biointerphases
https://www.readbyqxmd.com/read/30227347/an-azine-based-carbothioamide-chemosensor-for-selective-and-sensitive-turn-on-off-sequential-detection-of-zn-ii-and-h-2-po-4-live-cell-imaging-and-inhibit-logic-gate
#13
Rakesh Purkait, Ananya Das Mahapatra, Debprasad Chattopadhyay, Chittaranjan Sinha
Hydrazino-carbothioamide, 1, serves as a turn-on fluorescent chemosensor to Zn2+ and the mixture shows green emission (λem 492) in presence of large number of ions with impressive limit of detection (LOD), 0.59 nM. Intense fluorescence of Zn-complex is selectively turn-off upon adding H2 PO4 - only to the limit of detection, 26 μM, while other anions remain silent. The sensing mechanism of 1 is established by suppressing the ESIPT of 1 and complexation with Zn2+ (CHEF) is supported by Job's plot, 1 H NMR, and HR-MS data...
January 15, 2019: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/30220831/thiazoles-with-cyclopropyl-fragment-as-antifungal-anticonvulsant-and-anti-toxoplasma-gondii-agents-synthesis-toxicity-evaluation-and-molecular-docking-study
#14
Krzysztof Z Łączkowski, Natalia Konklewska, Anna Biernasiuk, Anna Malm, Kinga Sałat, Anna Furgała, Katarzyna Dzitko, Adrian Bekier, Angelika Baranowska-Łączkowska, Agata Paneth
Synthesis and investigation of antifungal, anticonvulsant and anti- Toxoplasma gondii activities of ten novel (2-(cyclopropylmethylidene)hydrazinyl)thiazole 3a - 3j are presented. Among the derivatives, compounds 3a - 3d and 3f - 3j possess very high activity against Candida spp. ATCC with MIC = 0.015-7.81 µg/ml. Compounds 3a - 3d and 3f - 3j possess also very high activity towards most of strains of Candida spp. isolated from clinical materials with MIC = 0.015-7.81 µg/ml. The activity of these compounds is similar and even higher than the activity of nystatin used as positive control...
2018: Medicinal Chemistry Research
https://www.readbyqxmd.com/read/30219365/rapid-quantification-of-vesicular-stomatitis-virus-in-vero-cells-using-laser-force-cytology
#15
Colin G Hebert, Nicole DiNardo, Zachary L Evans, Sean J Hart, Anna-Barbara Hachmann
The ability to rapidly and accurately determine viral infectivity can help improve the speed of vaccine product development and manufacturing. Current methods to determine infectious viral titers, such as the end-point dilution (50% tissue culture infective dose, TCID50) and plaque assays are slow, labor intensive, and often subjective. In order to accelerate virus quantification, Laser Force Cytology (LFC) was used to monitor vesicular stomatitis virus (VSV) infection in Vero (African green monkey kidney) cells...
October 1, 2018: Vaccine
https://www.readbyqxmd.com/read/30214457/4-phenyl-1-3-thiazole-2-amines-as-scaffolds-for-new-antileishmanial-agents
#16
Carina Agostinho Rodrigues, Paloma Freire Dos Santos, Marcela Oliveira Legramanti da Costa, Thais Fernanda Amorim Pavani, Patrícia Xander, Mariana Marques Geraldo, Ana Mengarda, Josué de Moraes, Daniela Gonçales Galasse Rando
Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis . Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/30213846/evaluation-of-a-novel-pet-radioligand-to-image-o-glcnacase-in-brain-and-periphery-of-rhesus-monkey-and-knock-out-mouse
#17
Soumen Paul, Mohammad B Haskali, Jeih-San Liow, Sami S Zoghbi, Vanessa N Barth, Marcy Comly Kolodrubetz, Michelle R Bond, Cheryl L Morse, Robert L Gladding, Michael P Frankland, Nancy Kant, Lawrence Slieker, Sergey Shcherbinin, Hugh N Nuthall, Paolo Zanotti-Fregonara, John A Hanover, Cynthia Jesudason, Victor W Pike, Robert B Innis
Accumulation of hyper-phosphorylated tau, a microtubule-associated protein, plays an important role in the progression of Alzheimer's disease (AD). Animal studies suggest that one strategy for treating AD and related tauopathies may be inhibition of O-GlcNAcase (OGA), which may subsequently decrease pathological tau phosphorylation Here, we report the pharmacokinetics of a novel positron emission tomography (PET) radioligand, 18 F-LSN3316612, which binds with high affinity and selectivity to OGA. Methods: PET imaging was performed in rhesus monkeys at baseline and after administration of either thiamet G, a potent OGA inhibitor, or nonradioactive LSN3316612...
September 13, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/30198266/effects-of-decavanadate-salts-with-organic-and-inorganic-cations-on-escherichia-coli-giardia-intestinalis-and-vero-cells
#18
Juliana M Missina, Bruno Gavinho, Kahoana Postal, Francielli S Santana, Glaucio Valdameri, Emanuel M de Souza, David L Hughes, Marcel I Ramirez, Jaísa F Soares, Giovana G Nunes
Decavanadate salts with nicotinamide (3-pyridinecarboxamide, 3-pca) and isonicotinamide (4-pyridinecarboxamide, 4-pca) in both neutral and protonated forms, (3-Hpca)4 [H2 V10 O28 ]·2H2 O·2(3-pca) (complex I) and (4-Hpca)4 [H2 V10 O28 ]·2(4-pca) (complex II), have been synthesized and characterized by vibrational spectroscopy (infrared and Raman), thermogravimetric analysis (TGA), 51 V NMR, and single-crystal X-ray diffraction analysis. The effects of sodium decavanadate (henceforth called NaV10 ) and compounds I and II on Escherichia coli, Giardia intestinalis, and Vero (African green monkey epithelial kidney) cells were evaluated...
October 1, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/30179610/tp0463518-a-novel-inhibitor-for-hypoxia-inducible-factor-prolyl-hydroxylases-increases-erythropoietin-in-rodents-and-monkeys-with-a-good-pharmacokinetics-pharmacodynamics-correlation
#19
Sota Kato, Noriko Takayama, Hiroki Takano, Hiroko Koretsune, Chie Koizumi, Ei-Ichi Kunioka, Saeko Uchida, Teisuke Takahashi, Koji Yamamoto
Hypoxia-inducible factor prolyl hydroxylases (PHDs) inhibitor stabilizes hypoxia inducible factor alpha, which increases erythropoietin (EPO) expression via the hypoxia response element. Therefore, PHDs inhibitors have been developed as novel therapeutic agents for anemia. Here, we characterize the in vitro and in vivo pharmacological profiles of TP0463518, 2-[[1-[[6-(4-chlorophenoxy)pyridin-3-yl]methyl]-4-hydroxy-6-oxo-2,3-dihydropyridine-5-carbonyl]amino]acetic acid, a novel potent PHDs inhibitor. TP0463518 competitively inhibited human PHD2 with a Ki value of 5...
September 1, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/30155487/renal-ischemia-reperfusion-injury-in-a-diabetic-monkey-model-and-therapeutic-testing-of-human-bone-marrow-derived-mesenchymal-stem-cells
#20
Kyo Won Lee, Tae Min Kim, Kyeong Sik Kim, Seunghwan Lee, Junhun Cho, Jae Berm Park, Ghee Young Kwon, Sung Joo Kim
Clinically, acute kidney injury (AKI) episodes in diabetes mellitus (DM) patients are associated with a cumulative risk of developing end-stage renal disease. In this study, we asked whether the severity of AKI induced by renal ischemia-reperfusion injury (IRI) is more prominent in DM than in non-DM control using a cynomolgus monkey ( Macaca fascicularis) model. We also investigated whether human bone marrow-derived mesenchymal stem cells (hBM-MSCs) infused via the renal artery could ameliorate renal IRI in DM monkeys...
2018: Journal of Diabetes Research
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