Marlena Tynecka, Adrian Janucik, Magdalena Niemira, Arkadiusz Zbikowski, Nino Stocker, Agnieszka Tarasik, Aleksandra Starosz, Kamil Grubczak, Anna Szalkowska, Urszula Korotko, Joanna Reszec, Miroslaw Kwasniewski, Adam Kretowski, Cezmi Akdis, Milena Sokolowska, Marcin Moniuszko, Andrzej Eljaszewicz
Mesenchymal stem cells (mesenchymal stromal cells; MSC)-based therapies remain a promising approach to treat degenerative and inflammatory diseases. Their beneficial effects were confirmed in numerous experimental models and clinical trials. However, safety issues concerning MSCs' stability and their long-term effects limit their implementation in clinical practice, including treatment of respiratory diseases such as asthma, chronic obstructive pulmonary disease, and COVID-19. Here, we aimed to investigate the safety of intranasal application of human adipose tissue-derived MSCs in a preclinical experimental mice model and elucidate their effects on the lungs...
2022: Frontiers in Immunology