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https://www.readbyqxmd.com/read/27920018/a-phase-ii-randomized-placebo-controlled-trial-of-oral-n-acetylcysteine-for-protection-of-melanocytic-nevi-against-uv-induced-oxidative-stress-in-vivo
#1
Pamela B Cassidy, Tong Liu, Scott R Florell, Matthew Honeggar, Sancy A Leachman, Kenneth M Boucher, Douglas Grossman
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acute UV exposure. The minimal erythemal dose (MED) was determined for 100 patients at increased risk for melanoma. Patients were randomized to receive a single dose (1,200 mg) of NAC or placebo, in double-blind fashion, and then one nevus was irradiated (1-2 MED) using a solar simulator...
December 5, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27916254/pigmented-oral-compound-nevus-of-retromolar-area-a-rare-case-report
#2
Virender Gombra, Mandeep Kaur, Keya Sircar, Deepika Bablani Popli
Solitary pigmented melanocytic intraoral lesions of the oral cavity are rare. Oral nevus is a congenital or acquired benign neoplasm. Oral compound nevus constitutes 5.9%-16.5% of all oral melanocytic nevi. The oral compound nevus is commonly seen on hard palate and buccal mucosa and rarely on other intraoral sites. The objective of this article is to present a rare case report of oral compound nevus in the retromolar pad region along with a review of literature. A 22 year old female reported with a solitary black pigmented papule at retromolar pad region which was surgically removed and microscopic investigation confirmed the diagnosis of oral compound nevus...
December 2016: Singapore Dental Journal
https://www.readbyqxmd.com/read/27761393/mandibular-metastasis-of-cutaneous-melanoma
#3
Josi Amadeu, Cleto Mariosvaldo Piazzetta, Cassius Carvalho Torres-Pereira, José Miguel Amenábar
Melanoma is a malignant neoplasm of melanocytes that can metastasize to every organ of the body, but metastasis to the oral cavity is uncommon. We describe a case of metastatic malignant melanoma to the mandible in a 33-years-old woman. The patient had a 2 cm × 4 cm firm, ulcerated nodule, distal to the second mandibular right molar. Incisional biopsy revealed epithelioid cells and immunohistochemistry was positive for HMB-45, S-100 protein and vimentin. The patient was referred to the local cancer hospital for treatment but died 3 months later...
September 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27709427/s-100-negative-granular-cell-tumor-so-called-primitive-polypoid-non-neural-granular-cell-tumor-of-the-oral-cavity
#4
Yeshwant B Rawal, Thomas B Dodson
Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma...
October 5, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27561155/design-of-cyclized-selective-melanotropins
#5
REVIEW
Minying Cai, Victor J Hruby
This article describes the development of cyclic peptides for G-protein coupled receptors to enable structure-function knowledge and the design of novel therapeutics. One important property of cyclic peptides is that they tend to be resistant to the digestion, enabling them to survive in the human digestive tract. This trait makes them very important as drug leads or as scaffolds which, in theory, can be engineered to incorporate a peptide domain of medicinal value. This is especially important for delivery of peptides that would be destroyed without such implementation...
November 2016: Biopolymers
https://www.readbyqxmd.com/read/27522713/-melanoma-and-human-papillomaviruses-is-there-an-outlook-for-study
#6
REVIEW
G M Volgareva, I N Mikhaylova, D A Golovina
Melanoma is one of the most aggressive human malignant tumors. Its incidence and mortality are growing steadily. Ultraviolet irradiation is the main risk factor for melanoma involved in melanomagenesis. The probability of viral etiology of melanoma has been discussed. Human papillomaviruses (HPV) have been mentioned among candidates for its etiologic agents because some HPV types are the powerful carcinogens causing cervical cancer and other cancers. The review analyses the literature data on the association of melanoma with HPV Several groupsfound HPVin skin melanomas as well as in mucosa; viruses of high oncogenic risk were detected in some cases...
2016: Vestnik Rossiĭskoĭ Akademii Meditsinskikh Nauk
https://www.readbyqxmd.com/read/27428182/a-systematic-review-perivascular-epithelioid-cell-tumor-of-gastrointestinal-tract
#7
Zehong Chen, Siqi Han, Jialin Wu, Minmin Xiong, Yanqiao Huang, Jianhui Chen, Yujie Yuan, Jianjun Peng, Wu Song
Perivascular epithelioid cell tumor (PEComa) is a rare entity with distinctive morphology and of expressing myomelanocytic markers. Gastrointestinal tract (GI) is one of the most common anatomic sites of origin and counts for 20% to 25% of all reported cases of perivascular epithelioid cell tumors not otherwise specified (PEComas-NOS). However, the biologic behavior of perivascular epithelioid cell tumors of gastrointestinal tract (GI PEComas-NOS) is still unclear. The aim of conducting this systematic review is to sum up what is known so far of the epidemiology, natural history, management and prognosis of GI PEComas-NOS...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27398186/pathogenesis-and-clinicohistopathological-caractheristics-of-melanoacanthoma-a-systematic-review
#8
REVIEW
Elena Cantudo-Sanagustín, Aída Gutiérrez-Corrales, Manuel Vigo-Martínez, María-Ángeles Serrera-Figallo, Daniel Torres-Lagares, José-Luis Gutiérrez-Pérez
INTRODUCTION: The melanoacanthoma is a rare benign pigmented tumor, characterized by a fast radial growth and clinical behavior similar to melanoma. Color changes in oral mucosa and dermis are consequence of increased melanocyte activity as response to an irritant factor. There is a vast phenotypic variety. It is difficult to distinguish between a benign pigmented lesion and a melanoma at its early stage. Due to its clinical relevance is crucial to diagnose possible malignancy of the lesions...
July 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27270028/metastatic-solid-tumors-to-the-jaw-and-oral-soft-tissue-a-retrospective-clinical-analysis-of-44-patients-from-a-single-institution
#9
Adepitan A Owosho, Bin Xu, Arvin Kadempour, SaeHee K Yom, Joseph Randazzo, Ronald A Ghossein, Joseph M Huryn, Cherry L Estilo
PURPOSE: Metastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients' clinical outcomes. MATERIAL AND METHODS: A retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center...
August 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27195264/oral-malignant-melanoma-initially-misdiagnosed-as-a-racial-pigmentation-a-case-report
#10
Carla Patrícia Martinelli-Kläy, Marcel Leandro Laporte, Celso Ricardo Martinelli, Celso Martinelli, Tommaso Lombardi
Oral malignant melanoma (OMM) is rare, representing less than 0.5% of all oral malignancies. The most affected sites are the palate and the maxillary gingiva. Histological examination is important to establish the diagnosis of any suspicious pigmented lesion in the oral cavity, mainly if a precise clinical diagnosis is not possible. We present one case of OMM that was initially diagnosed as a racial pigmentation elsewhere 2 years earlier. Clinical examination showed multiple macules and nodules located on the hard and soft palate, gingiva and superior alveolar mucosa...
January 2016: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/27177643/in-situ-melanoma-of-the-gingiva-associated-with-dense-inflammation-and-pigment-deposition-a-potential-diagnostic-pitfall-in-evaluating-stromal-invasion
#11
Bruno Tavares Sedassari, Nelise Alexandre da Silva Lascane, André Luis Santana de Freitas, Mário Cláudio Mautoni, Mirian Nacagami Sotto, Marina Helena Cury Gallottini, Suzana Cantanhede Orsini Machado de Sousa, Décio Dos Santos Pinto
Melanoma is a highly aggressive neoplasm in which the neoplastic cells display melanocytic differentiation. Less than 1 % of all melanomas arise in the mucosal surfaces of the oral cavity, with purely in situ lesions being exceedingly rare tumors, but with a favorable prognosis compared with invasive lesions. We describe the clinical, histopathological and immunohistochemical findings in an uncommon case of in situ mucosal melanoma of the oral cavity with intense tumor-associated pigment deposition and inflammation complicating the morphological assessment of infiltrative areas...
December 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27173008/oral-tranexamic-acid-lightens-refractory-melasma
#12
Aaron Wei Min Tan, Priya Sen, Sze Hon Chua, Boon Kee Goh
BACKGROUND/OBJECTIVES: Melasma is a common acquired hyperpigmentary disorder, particularly among Asians and Hispanics, but its exact pathomechanism is poorly understood. Tranexamic acid has been found to lighten melasma by interfering with the interaction of melanocytes and keratinocytes by inhibiting the plasminogen/plasmin system. The aim was to evaluate the therapeutic effects of oral tranexamic acid in the treatment of melasma refractory to topical skin-lightening agents. METHODS: This retrospective study analyses patients with melasma recruited from a tertiary dermatological centre in Singapore between 1 August 2009 and 31 March 2011...
May 13, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27152719/cathepsin-k-expression-is-increased-in-oral-lichen-planus
#13
Maria Siponen, Carolina Cavalcante Bitu, Ahmed Al-Samadi, Pentti Nieminen, Tuula Salo
BACKGROUND: Oral lichen planus (OLP) is an idiopathic T-cell-mediated mucosal inflammatory disease. Cathepsin K (Cat K) is one of the lysosomal cysteine proteases. It is involved in many pathological conditions, including osteoporosis and cancer. The expression and role of Cat K in OLP are unknown. METHODS: Twenty-five oral mucosal specimens diagnosed histopathologically as OLP and fourteen healthy controls (HC) were used to study the immunohistochemical (IHC) expression of Cat K...
May 6, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27147111/collision-tumour-of-squamous-cell-carcinoma-and-malignant-melanoma-in-the-oral-cavity-of-a-dog
#14
F Rodríguez, P Castro, G A Ramírez
A 7-year-old, male cocker spaniel was presented with a gingival proliferative lesion in the rostral maxilla and enlargement of the regional lymph node. Morphological and immunohistochemical analysis revealed a collision tumour composed of two malignant populations, epithelial and melanocytic, with metastasis of the neoplastic melanocytes to the regional lymph node. The epithelial component consisted of trabeculae and islands of well-differentiated squamous epithelium immunoreactive to cytokeratins. The melanocytic component had a varying degree of pigmentation of polygonal and spindle-shaped cells, growing in nests or densely packed aggregates and immunolabelled with S100, melanoma-associated antigen (melan A), neuron-specific enolase and vimentin antibodies...
May 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/27114959/oral-malignant-melanoma-an-aggressive-clinical-entity-report-of-a-rare-case-with-review-of-literature
#15
Shamimul Hasan, Sami Faisal Jamdar, Jogender Jangra, Sadun Mohammad Al Ageel Al Beaiji
Melanomais one of the most dreaded and aggressive neoplasms, being derived from epidermal melanocytes. The majority of melanomas are seen to involve the skin, and primary mucosal melanomas account for less than 1% of all melanomas. Oral malignant melanomas (OMM) are asymptomatic at the initial presentation, but later they become painful with growth and expansion. In the late stages, the patient may present with ulceration, bleeding, tooth mobility, paresthesia, ill-fitting prosthesis, and delayed healing of the extraction sockets...
March 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27041909/primary-malignant-melanoma-of-oral-cavity-a-report-of-three-rare-cases
#16
Hanspal Singh, Priya Kumar, Jeyaseelan Augustine, Aadithya B Urs, Sunita Gupta
Oral malignant melanoma (OMM) is a rare tumor of melanocytic origin, accounting for 20-30% of malignant melanomas at the mucosal surface and 16% intra-orally. Hard palate and maxillary gingiva are the most common involved sites. In this case series, we present varying patterns of presentation of three cases of OMM with one case of distant metastasis. All cases in the current series presented at an advanced stage and died within a year of diagnosis. In conclusion, due to the aggressive clinical course and poor prognosis of this deadly lesion, it is of paramount importance to maintain a high index of suspicion for early detection and diagnosis for any pigmented lesion in the oral cavity...
January 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27039005/primary-mucosal-melanoma-of-the-oral-cavity-current-therapy-and-future-directions
#17
REVIEW
Ioannis Chatzistefanou, Antonia Kolokythas, Konstantinos Vahtsevanos, Konstantinos Antoniades
BACKGROUND: Primary mucosal melanoma of the oral cavity is a highly aggressive malignancy of melanocytic origin. The aim of this study is to report a case series of oral mucosal melanomas (OMMs) and provide a review of the literature with regard to treatment guidelines for and prognosis of this pathologic entity. STUDY DESIGN: We report three cases of OMMs treated in our institutions and the results of a literature review, in which the words "oral" and "mucosal melanoma" were used as the main keywords...
July 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27001333/spitz-nevus-a-rare-lesion-of-the-oral-cavity
#18
Mario Vaccaro, Umberto Romeo, Carmelo Romeo, Maria Lentini
Pigmented mucosal lesions represent a group of rare entities with different etiopathogenetic origins, histopathologic features, dermoscopic appearances, and clinical course. Solitary pigmented lesions of melanocytic origin are uncommon in the oral mucosa, and intraoral occurrence of Spitz nevus is very rare. Here we present a case of Spitz nevus occurring on the hard palate of a 26-month-old boy.
March 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/26805740/oral-squamomelanocytic-tumour-in-a-dog-a-unique-biphasic-cancer
#19
L V Muscatello, G Avallone, C Benazzi, G Sarli, I Porcellato, C Brachelente, B Brunetti
In human medicine, squamomelanocytic tumour is a malignant cutaneous neoplasm composed of closely intermingled neoplastic squamous cells and melanocytes. A multinodular gingival tumour in a 16-year-old, mixed breed neutered female dog was examined microscopically. Two populations of neoplastic cells, melanocytic and squamous epithelial cells were intermingled. The melanocytic cells were melan-A positive and cytokeratin AE1-AE3 negative and the squamous component was cytokeratin AE1-AE3 positive and melan-A negative...
February 2016: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/26788204/a-rare-case-of-amelanotic-malignant-melanoma-in-the-oral-region-clinical-investigation-and-immunohistochemical-study
#20
Yuichi Ohnishi, Masahiro Watanabe, Tomoko Fujii, Noriko Sunada, Hitoshi Yoshimoto, Hirohito Kubo, Masahiro Wato, Kenji Kakudo
Amelanotic malignant melanoma (AMM) is rare in the oral region. The present study examined the clinical features of this tumor in an attempt to establish diagnostic criteria. The expression of three melanocytic differentiation markers, HMB-45, S-100 and Melan-A, was also measured in primary oral AMMs in order to determine whether the markers could be used to diagnose primary oral AMMs and to find out which marker was the most sensitive. It may be particularly difficult to correctly diagnose AMM that lacks a radial growth phase without immunohistochemical assistance...
December 2015: Oncology Letters
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