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Pertussis vaccines

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https://www.readbyqxmd.com/read/28723872/marked-under-reporting-of-pertussis-requiring-hospitalization-in-infants-as-estimated-by-capture-recapture-methodology-germany-2013-2015
#1
Anika Schielke, Anja Takla, Rüdiger von Kries, Ole Wichmann, Wiebke Hellenbrand
BACKGROUND: In Germany, pertussis became notifiable in eastern federal states in 2002 and nationwide in March 2013. Infants are at greatest risk for severe disease, with a high proportion requiring hospitalization. We implemented enhanced hospital-based surveillance to estimate the incidence of pertussis requiring hospitalization among infants in Germany and to determine the proportion of infants hospitalized with pertussis too young to have been vaccinated. METHODS: Enhanced surveillance was implemented within a nationwide hospital surveillance network (ESPED)...
July 18, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28720318/immunogenicity-and-protective-efficacy-of-a-newly-developed-tri-component-diphtheria-tetanus-and-acellular-pertussis-vaccine-in-a-murine-model
#2
Dong Ho Huh, Seung Beom Han, Hye Jo Shin, Dong Ho Ahn, Gi Sub Choi, Kyu Ri Kang, Bo Ram Kim, Jin Han Kang
BACKGROUND/PURPOSE: Although assessing the immunogenicity and protective efficacy of acellular pertussis (aP) vaccines via murine model studies faces limitations, preliminary assessments have been achieved by evaluating respiratory challenge and humoral and cellular immunity. METHODS: We performed a long-term intranasal respiratory challenge with reference and clinically isolated strains of Bordetella pertussis. Simultaneously, we assessed humoral and cellular immunity for evaluating the immunogenicity of a newly developed tri-component diphtheria-tetanus-aP (DTaP) vaccine...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28720089/analysis-of-the-association-between-millennium-development-goals-4-5-and-the-physician-workforce-across-international-economic-strata
#3
Christopher P Morley, Dongliang Wang, Emily M Mader, Kyle P Plante, Lindsey N Kingston, Azadeh Rabiei
BACKGROUND: The Millennium Development Goals (MDGs) are 8 international development goals voluntarily adopted by 189 nations. The goals included health related aims to reduce the under-five child mortality rate by two-thirds (MDG4), and to reduce the maternal mortality ratio by three-quarters (MDG5). To assess the relationship between the healthcare workforce and MDGs 4-5, we examined the physician workforces of countries around the globe, in terms of the Physician Density Level (PDL, or number of physicians per 1000 population), and compared this rate across a number of years to several indicator variables specified as markers of progress towards MDG4 and MDG5...
July 18, 2017: BMC International Health and Human Rights
https://www.readbyqxmd.com/read/28719500/a-randomized-controlled-study-of-a-fully-liquid-dtap-ipv-hb-prp-t-hexavalent-vaccine-for-primary-and-booster-vaccinations-of-healthy-infants-and-toddlers-in-latin-america
#4
Pío López, Adriano Arguedas Mohs, Arturo Abdelnour Vásquez, Maria Consuelo-Miranda, Emmanuel Feroldi, Fernando Noriega, Emilia Jordanov, Siham B'Chir, Betzana Zambrano
BACKGROUND: Hexavalent diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae type b (PRP-T)-containing vaccines are increasingly the standard of care. This study evaluated the primary series (NCT01177722) and booster (NCT01444781) of a fully liquid DTaP-IPV-HB-PRP-T vaccine in Latin America. METHODS: Infants (N=1375) received HB vaccine at birth and were randomized to one of three batches of the investigational DTaP-IPV-HB-PRP-T or licensed control vaccine (DTaP-HB-IPV//PRP-T) at 2-4-6 months of age, co-administered with 7-valent pneumococcal conjugate vaccine (PCV7) (2-4-6 months) and rotavirus vaccine (2-4 months)...
July 14, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28715411/a-curated-genome-scale-metabolic-model-of-bordetella-pertussis-metabolism
#5
Nick Fyson, Jerry King, Thomas Belcher, Andrew Preston, Caroline Colijn
The Gram-negative bacterium Bordetella pertussis is the causative agent of whooping cough, a serious respiratory infection causing hundreds of thousands of deaths annually worldwide. There are effective vaccines, but their production requires growing large quantities of B. pertussis. Unfortunately, B. pertussis has relatively slow growth in culture, with low biomass yields and variable growth characteristics. B. pertussis also requires a relatively expensive growth medium. We present a new, curated flux balance analysis-based model of B...
July 17, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28701222/how-well-do-icd-9-physician-claim-diagnostic-codes-identify-confirmed-pertussis-cases-in-alberta-canada-a-canadian-immunization-research-network-cirn-study
#6
Sumana Fathima, Kimberley A Simmonds, Steven J Drews, Lawrence W Svenson, Jeffrey C Kwong, Salaheddin M Mahmud, Susan Quach, Caitlin Johnson, Kevin L Schwartz, Natasha S Crowcroft, Margaret L Russell
BACKGROUND: Rates of Bordetella pertussis have been increasing in Alberta, Canada despite vaccination programs. Waning immunity from existing acellular component vaccines may be contributing to this. Vaccine effectiveness can be estimated using a variety of data sources including diagnostic codes from physician billing claims, public health records, reportable disease and laboratory databases. We sought to determine if diagnostic codes from billing claims (administrative data) are adequately sensitive and specific to identify pertussis cases among patients who had undergone disease-specific laboratory testing...
July 12, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28696824/age-appropriate-versus-up-to-date-coverage-of-routine-childhood-vaccinations-among-young-children-in-israel
#7
Chen Stein-Zamir, Avi Israeli
BACKGROUND AND AIMS: Routine childhood vaccinations schedules recommend that children receive the vaccine doses at specific ages. Vaccination coverage data are conventionally reported by the up-to-date method. We aimed to assess vaccination timeliness by the age-appropriate method and compare to the up-to-date vaccination coverage. METHODS: Assessment of age-appropriate and up-to-date vaccination coverage among children born in Israel in 2009 and followed to age 48 months (national representative sample, n = 3892)...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28686396/-recommendations-for-the-vaccination-of-pregnant-women-a-booster-injection
#8
Yolanda Mueller, Christiane Sigrid Eberhardt, Alessandro Diana, Begoña Martinez De Tejada
For several decades we have avoided the immunisation of pregnant women, with the only exception being that of the tetanus vaccination in the absence of a previous basic immunisation. Nowadays, it is strongly advised to give several vaccines specifically during pregnancy : maternal immunisations against pertussis and influenza have been shown to prevent complications in both the foetus and the newborn as well as the woman during pregnancy and after delivery. This article aims to review these recommendations, their rationale and to address potential concerns that are often raised by physicians and patients...
October 12, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28685134/vaccinations-against-respiratory-infections-in-arabian-gulf-countries-barriers-and-motivators
#9
Amani S Alqahtani, Daniah M Bondagji, Abdullah A Alshehari, Mada H Basyouni, Tariq M Alhawassi, Nasser F BinDhim, Harunor Rashid
AIM: To study the uptake, barriers and motivators of influenza, pneumococcal, meningococcal and pertussis vaccines among members of public in Arabian Gulf countries. METHODS: A cross-sectional survey among the Gulf Cooperation Council (GCC) countries' residents. Data collected electronically through a smartphone app. The survey variables aimed to investigate the respondents' awareness about vaccines against influenza, pneumococcal, meningococcal and pertussis infections...
June 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28666760/vaccination-coverage-among-social-and-healthcare-workers-in-ten-countries-of-samu-social-international-sites
#10
Esaie Marshall, Dominique Salmon, Delphine Laisney, Nadia Bousfiha, Yacouba Togola, François Ouedraogo, Maud Santantonio, Coumba Khadidja Dieng, Suzanne Tartière, Xavier Emmanuelli
BACKGROUND: We aim to determine the vaccination coverage of social and healthcare workers in International sites of Samusocial, providing emergency care to homeless people, and to assess factors associated with having received necessary doses at adulthood. METHODS: Data on immunization coverage of social and healthcare workers were provided by a cross-sectional survey, conducted from February to April 2015 among 252 Samusocial workers in 10 countries. Vaccination status and characteristics of participants were collected through a self-administered questionnaire...
June 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28661516/knowledge-attitudes-beliefs-and-practices-of-occupational-physicians-towards-vaccinations-of-health-care-workers-a-cross-sectional-pilot-study-in-north-eastern-italy
#11
Matteo Riccò, Silvia Cattani, Franca Casagranda, Giovanni Gualerzi, Carlo Signorelli
OBJECTIVES: This study aims to characterize personal attitudes and knowledge of a sample of Italian occupational physicians (OPhs) towards immunization practice in the case of healthcare workers (HCWs). MATERIAL AND METHODS: A total of 90 OPhs (42.2% of males, 57.8% of females, mean age of 50.1±8.3 years old) compiled a structured questionnaire through a telephonic interview. They were asked about the official Italian recommendations for HCWs, their general knowledge of vaccine practice, their propensity towards vaccines (both in general and about specific immunizations), their risk perception about the vaccine-preventable infectious diseases...
June 29, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28654742/the-safety-and-effectiveness-of-vaccination-against-influenza-and-pertussis-in-pregnant-women
#12
Ewa Augustynowicz, Anna Lutyńska, Anna Piotrowska, Iwona Paradowska- Stankiewicz
In recent years a large amount of data has become available with regard to vaccinating women during pregnancy against influenza and against pertussis. The data comes from observational studies conducted when vaccine was administered as a part of a vaccination campaign, retrospective evaluations of databases and surveillance of the adverse post-vaccination events. Popularization of knowledge about the importance of immunization in this group and educating pregnant women about vaccination should be an essential element of health promotion and prevention programs...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28654562/cardio-respiratory-events-and-inflammatory-response-after-primary-immunization-in-preterm-infants-32-weeks-gestational-age-a-randomized-controlled-study
#13
Wissal Ben Jmaa, Alfredo I Hernández, Megan Sutherland, Anik Cloutier, Nathalie Germain, Christian Lachance, Brigitte Martin, Marc H Lebel, Patrick Pladys, Anne Monique Nuyt
BACKGROUND: Inflammation may depress respiration in neonates. This study aimed to establish a link between post-immunization inflammation and cardio-respiratory events (CRE). METHODS: Randomized double-blind controlled study of infants born <32 weeks gestation receiving the 2 months vaccine which comprised diphtheria and tetanus toxoids and acellular pertussis adsorbed combined with inactivated poliomyelitis vaccines, and Haemophilus b conjugate and the pneumococcal conjugate 10-valent vaccines...
June 24, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28651837/severe-underestimation-of-pertussis-related-hospitalizations-and-deaths-in-the-netherlands-a-capture-recapture-analysis
#14
N A T van der Maas, J Hoes, E A M Sanders, H E de Melker
OJECTIVE: Despite vaccination, pertussis has remained endemic, sometimes leading to severe disease. We aimed to quantify the completeness of reporting (CoR) of pertussis hospitalizations and deaths in the Netherlands. STUDY DESIGN: CoR was estimated using capture-recapture analyses. Hospitalizations (2007-2014) from the National Registration Hospital Care (hospital data) were matched to the notifiable Infectious Disease case registry (notifications) providing (month and) year of birth, gender and postal code...
June 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28646950/pertussis-disease-and-transmission-and-host-responses-insights-from-the-baboon-model-of-pertussis
#15
Marta V Pinto, Tod J Merkel
Whooping cough is a highly contagious, acute respiratory disease, caused by the Gram-negative bacterium Bordetella pertussis (Bp). Despite the introduction and widespread use of vaccines starting in the 1950s pertussis cases continue to be reported, with a significant global impact. The role of specific virulence factors in disease and the immune mechanisms associated with protection following natural infection or vaccination are still not completely understood. The recently-developed baboon model of clinical pertussis provides a valuable tool for the study of pertussis...
June 2017: Journal of Infection
https://www.readbyqxmd.com/read/28646697/seroepidemiology-of-whooping-cough-in-the-czech-republic-estimates-of-incidence-of-infection-in-adults
#16
R Chlibek, J Smetana, R Sosovickova, K Fabianova, J Zavadilova, P Dite, P Gal, P Naplava, D Lzicarova
OBJECTIVES: Despite widespread vaccination programmes, pertussis remains a significant health burden in many countries. Low awareness of the disease, the high rate of asymptomatic cases in adults and difficulties with diagnosis could explain the under-reporting of pertussis. The lack of data on actual incidence constitutes an obstacle for public health authorities for the implementation of a vaccination strategy against pertussis in adults. The aim of this study was to evaluate the seroprevalence of antibodies against Bordetella pertussis infection in adults and to estimate the actual incidence of the disease compared with the reported incidence...
June 21, 2017: Public Health
https://www.readbyqxmd.com/read/28634290/geospatial-analysis-of-nonmedical-vaccine-exemptions-and-pertussis-outbreaks-in-the-united-states
#17
Carlin Aloe, Martin Kulldorff, Barry R Bloom
Because of increased numbers of recorded pertussis cases in the United States, this study sought to understand the role of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertussis in the United States at the community level. We used geospatial scan statistics, SaTScan, version 9.4, to analyze nonmedical vaccine exemptions of children entering kindergarten in 2011 and 2012 and reported pertussis cases in 2012 for children in age groups 5 years and younger and 10 to 14 years...
July 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28623456/pertussis-and-rotavirus-vaccines-controversies-and-solutions
#18
REVIEW
Nabaneeta Dash, Sanjay Verma
Pertussis and rotavirus vaccines have been the subject of several controversies over the years. In this paper the authors discuss facts and myths behind these controversies and also suggest solutions to overcome some limitations of these vaccines. The whole-cell pertussis vaccine (wPV) came into disrepute due to the associated adverse reactions, resulting in its replacement by acellular pertussis vaccine (aPV) in industrialized nations in 1990s. Although wPV is known to have more side effects; but they are usually minor...
June 16, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28623146/an-update-of-the-global-burden-of-pertussis-in-children-younger-than-5-years-a-modelling-study
#19
Karene Hoi Ting Yeung, Philippe Duclos, E Anthony S Nelson, Raymond Christiaan W Hutubessy
BACKGROUND: Since the publication in 2003 of a model to estimate the disease burden of pertussis, new evidence of the protective effect of incomplete pertussis vaccination against severe pertussis has been reported. We revised the model to provide new estimates of regional and global pertussis cases and deaths for children younger than 5 years. METHODS: We developed a revised model with data from 2014 to estimate pertussis cases and deaths. Pertussis cases were defined according to the WHO clinical case definition, as a coughing illness lasting at least 2 weeks with paroxysms of coughing, inspiratory whooping, or post-tussive vomiting...
June 13, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28621647/timeliness-and-completeness-of-routine-childhood-vaccinations-in-children-by-two-years-of-age-in-alberta-canada
#20
Vineet Saini, Shannon E MacDonald, Deborah A McNeil, Sheila W McDonald, James D Kellner, Sarah A Edwards, Victoria Stagg, Suzanne Tough
OBJECTIVES: Assessing timeliness and completeness of vaccine administration is important for evaluating the effectiveness of immunization programs. Few studies have reported timeliness, particularly in Canada. The objective of this study was to examine timeliness of the receipt of vaccination for each routine childhood recommended vaccine by 24 months of age among children in a community-based pregnancy cohort in Calgary, Alberta. METHODS: Survey data from a community-based pregnancy cohort in Alberta were linked to Public Health vaccination records of children (n = 2763)...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
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