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Pertussis vaccines

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https://www.readbyqxmd.com/read/29223483/differences-by-sex-in-igg-levels-following-infant-and-childhood-vaccinations-an-individual-participant-data-meta-analysis-of-vaccination-studies
#1
Anna G C Boef, Fiona R M van der Klis, Guy A M Berbers, Anne-Marie Buisman, Elisabeth A M Sanders, Jeanet M Kemmeren, Arie van der Ende, Hester E de Melker, Nynke Y Rots, Mirjam J Knol
BACKGROUND: If immune responses to vaccination differ between males and females, sex-specific vaccination schedules may be indicated. We systematically reanalysed childhood vaccination studies conducted in The Netherlands for sex-differences in IgG-responses. To assess the impact of potential sex-differences in IgG-responses, we explored sex-differences in vaccine failure/effectiveness and reactogenicity. METHODS: Six studies with IgG-measurements for 1577 children following infant pneumococcal (PCV7/PCV10/PCV13) and/or DTaP-IPV-Hib(-HepB) vaccinations, or the pre-school DTaP-IPV booster were included...
December 6, 2017: Vaccine
https://www.readbyqxmd.com/read/29223471/-clinical-epidemiological-study-of-bordetella-pertussis-infection-in-the-gran-canaria-island-in-the-period-2008-2016
#2
Laura Iglesias, Antonio Casabella Pernas, Melisa Hernández Febles, Elena Colino Gil, Alicia Eisman Maraver, María José Pena López
OBJECTIVE: Describe the epidemiological and clinical pattern of Bordetella pertussis infection (whooping cough) among hospitalised infants less than one year-old in a paediatric hospital in Gran Canaria. PATIENTS AND METHODS: A retrospective review of the patient hospital records was performed, and recording only those with a microbiological diagnosis of pertussis infection detected using polymerase chain reaction, from January 2008 to December 2016. RESULTS: A total of 110 patients were identified, of which 105 (95...
December 6, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29217370/a-quality-improvement-initiative-to-increase-tdap-tetanus-diphtheria-acellular-pertussis-vaccination-coverage-among-direct-health-care-providers-at-a-children-s-hospital
#3
Changhong Jiang, LaQuita Whitmore-Sisco, Aditya H Gaur, Elisabeth E Adderson
OBJECTIVES: Health care providers (HCP) are at high risk of acquiring and transmitting pertussis to susceptible family members, co-workers, and patients. Public health authorities recommend administering a single dose of Tdap (tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis) vaccine to all adults, including HCP, to increase adult immunity to pertussis. We set a quality improvement goal to increase Tdap vaccination coverage among HCP who provided direct patient care at a children's hospital from 58% to 90% over 18 months...
December 4, 2017: Vaccine
https://www.readbyqxmd.com/read/29208060/pertussis-epidemiology-prior-to-the-introduction-of-a-maternal-vaccination-program-queensland-australia
#4
L McHugh, K A Viney, R M Andrews, S B Lambert
Pertussis morbidity is highest in infants too young to be fully protected by routine vaccination schedules. Alternate vaccine strategies are required to maximise protection in this age-group. To understand baseline pertussis epidemiology prior to the introduction of the maternal pertussis vaccination program in 2014, we conducted a retrospective case series analyses of 53 901 notifications and temporal trends from 1997 to 2014. Notifications were highest in infants younger than 4 months of age and highest annual notification rates in infants younger than 1 month of age (308/100 000 per year)...
December 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29203737/-pertussis-in-children-with-incomplete-active-immunization
#5
Alexandr B Nadraga, Iryna V Dybas
INTRODUCTION: In recent years, a significant increase in the incidence of pertussis among children has been observed both in Ukraine and worldwide. Infants who were partially vaccinated or children who became ill in a short time after complete active immunization with primary vaccination complex against pertussis are more often referred to our clinic with the diagnosis of "pertussis". THE AIM: The clinical peculiarities of pertussis study in partially vaccinated infants and infants who are in the process of vaccination against pertussis...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29203497/outer-membrane-vesicles-omv-based-and-proteomics-driven-antigen-selection-identifies-novel-factors-contributing-to-bordetella-pertussis-adhesion-to-epithelial-cells
#6
Gianmarco Gasperini, Massimiliano Biagini, Vanessa Arato, Claudia Gianfaldoni, Alessandro Vadi, Nathalie Norais, Giuliano Bensi, Isabel Delany, Mariagrazia Pizza, Beatrice Aricò, Rosanna Leuzzi
Despite high vaccination coverage world-wide, whooping cough, a highly contagious disease caused by Bordetella pertussis, is recently increasing in occurrence suggesting that novel vaccine formulations targeted at the prevention of colonization and transmission should be investigated. In order to identify new candidates for inclusion in the acellular formulation, we used spontaneously released outer membrane vesicles (OMV) as a potential source of key adhesins. The enrichment of Bvg+ OMV with adhesins and the ability of anti-OMV serum to inhibit the adhesion of B...
December 4, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29199493/antenatal-vaccination-to-decrease-pertussis-in-infants-safety-effectiveness-timing-and-implementation
#7
Marina Lumbreras Areta, Christiane Sigrid Eberhardt, Claire-Anne Siegrist, Begoña Martinez de Tejada
Pertussis remains a serious global health issue in infants aged less than 6 months. Neonates and young infants have the highest risk of developing pertussis as they are too young to be vaccinated and thus are more likely to develop more severe pertussis-related complications, including death. Protecting this vulnerable age population from pertussis is considered a main priority in many national health programs. Two vaccine strategies exist to protect infants from pertussis: "cocooning" and maternal vaccination during pregnancy...
December 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29199041/whole-cell-or-acellular-pertussis-vaccination-in-infancy-determines-igg-subclass-profiles-to-dtap-booster-vaccination
#8
Saskia van der Lee, Elisabeth A M Sanders, Guy A M Berbers, Anne-Marie Buisman
INTRODUCTION: Duration of protection against pertussis is shorter in adolescents who have been immunized with acellular pertussis (aP) in infancy compared with adolescents who received whole-cell pertussis (wP) vaccines in infancy, which is related to immune responses elicited by these priming vaccines. To better understand differences in vaccine induced immunity, we determined pertussis, diphtheria, and tetanus (DTaP) vaccine antigen-specific IgG subclass responses in wP- and aP-primed children before and after two successive DTaP booster vaccinations...
November 30, 2017: Vaccine
https://www.readbyqxmd.com/read/29195189/-one-of-the-greatest-medical-success-stories-physicians-and-nurses-small-stories-about-vaccine-knowledge-and-anxieties
#9
Terra Manca
In recent years, the Canadian province of Alberta experienced outbreaks of measles, mumps, pertussis, and influenza. Even so, the dominant cultural narrative maintains that vaccines are safe, effective, and necessary to maintain population health. Many vaccine supporters have expressed anxieties that stories contradicting this narrative have lowered herd immunity levels because they frighten the public into avoiding vaccination. As such, vaccine policies often emphasize educating parents and the public about the importance and safety of vaccination...
November 20, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29194019/an-analysis-of-factors-associated-with-influenza-pneumoccocal-tdap-and-herpes-zoster-vaccine-uptake-in-the-us-adult-population-and-corresponding-inter-state-variability
#10
Elizabeth M La, Laurel Trantham, Samantha K Kurosky, Dawn Odom, Emmanuel Aris, Cosmina Hogea
Despite longstanding recommendations for routine vaccination against influenza; pneumococcal; tetanus, diphtheria, acellular pertussis (Tdap); and herpes zoster (HZ) among the United States general adult population, vaccine uptake remains low. Understanding factors that influence adult vaccination and coverage variability beyond the national level are important steps toward developing targeted strategies for increasing vaccination coverage. A retrospective analysis was conducted using data from the Behavioral Risk Factor Surveillance System (2011-2014)...
December 1, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29189613/is-there-a-need-for-a-stand-alone-acellular-pertussis-vaccine
#11
Ulrich Heininger
No abstract text is available yet for this article.
November 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29185899/vaccination-coverage-and-factors-associated-with-adherence-to-the-vaccination-schedule-in-young-children-of-a-rural-area-in-burkina-faso
#12
Moubassira Kagoné, Maurice Yé, Eric Nébié, Ali Sie, Anja Schoeps, Heiko Becher, Olaf Muller, Ane Baerent Fisker
BACKGROUND: Vaccination is an important tool for reducing infectious disease morbidity and mortality. In the past, less than 80% of children 12-23 months of age were fully immunized in Burkina Faso. OBJECTIVES: To describe coverage and assess factors associated with adherence to the vaccination schedule in rural area Burkina Faso. METHODS: The study population was extracted from the Nouna Health and Demographic surveillance system cohort...
2017: Global Health Action
https://www.readbyqxmd.com/read/29182938/does-disease-cause-vaccination-disease-outbreaks-and-vaccination-response
#13
Emily Oster
Parental fear of vaccines has limited vaccination rates in the United States. I test whether disease outbreaks increase vaccination using a new dataset of county-level disease and vaccination data. I find that pertussis (whooping cough) outbreaks in a county decrease the share of unvaccinated children entering kindergarten. These responses do not reflect changes in the future disease risk. I argue that these facts are best fit by a model in which individuals are both myopic and irrational. This suggests that better promotion of information about outbreaks could enhance the response...
November 2, 2017: Journal of Health Economics
https://www.readbyqxmd.com/read/29182350/using-the-4-pillars-to-increase-vaccination-among-high-risk-adults-who-benefits
#14
Mary Patricia Nowalk, Krissy K Moehling, Song Zhang, Jonathan M Raviotta, Richard K Zimmerman, Chyongchiou J Lin
OBJECTIVES: To compare changes in vaccination rates (pneumococcal polysaccharide vaccine [PPSV]; tetanus, diphtheria, and pertussis [Tdap] vaccine; and influenza vaccine) among high-risk adults following an intervention (June 1, 2013, to January 31, 2015) that used the 4 Pillars Practice Transformation Program (4 Pillars Program). STUDY DESIGN: Post hoc analysis of data from a randomized controlled cluster trial. METHODS: Eighteen primary care practices received staff education, guidance for using the 4 Pillars Program, and support for a practice immunization champion...
November 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/29181956/infectious-diseases-in-poland-in-2015
#15
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P. Czarkowski
PURPOSE OF THE STUDY: This is the next annual analysis of the situation of infectious and parasitic diseases in Poland in 2015 within the framework of the Epidemiological Chronicle of Przegląd Epidemiologiczny - Epidemiological Review. Its purpose is to identify potential threats to the health of populations from infectious diseases occurring in Poland with reference to other parts of the globe. MATERIAL AND METHODS: This paper is an introduction to more detailed studies of the epidemiological situation of selected infectious diseases and summarizes the results of the surveillance of infectious diseases in Poland in 2015...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/29181277/antibodies-to-bordetella-pertussis-antigens-in-maternal-and-cord-blood-pairs-a-thai-cohort-study
#16
Nasamon Wanlapakorn, Thanunrat Thongmee, Preeyaporn Vichaiwattana, Elke Leuridan, Sompong Vongpunsawad, Yong Poovorawan
Background: Pertussis is a vaccine-preventable disease, yet an increasing incidence of pertussis occurs in many countries. Thailand has a long-standing pertussis vaccination policy, therefore most expectant mothers today had received vaccines as children. The resurgence of pertussis among Thai infants in recent years led us to examine the pre-existing antibodies to Bordetella pertussis antigens in a cohort of 90 pregnant women. Methods: We evaluated the IgG to the Pertussis toxin (PT), filamentous hemagglutinin (FHA) and pertactin (PRN) in maternal and cord blood sera using commercial enzyme-linked immunosorbent assays (ELISA)...
2017: PeerJ
https://www.readbyqxmd.com/read/29180369/membrane-vesicles-derived-from-bordetella-bronchiseptica-active-constituent-of-a-new-vaccine-against-infections-caused-by-this-pathogen
#17
D Bottero, M E Zurita, M E Gaillard, E Bartel, C Vercellini, D Hozbor
Bordetella bronchiseptica, a Gram-negative bacterium, causes chronic respiratory-tract infections in a wide variety of mammalian hosts-humans included, albeit rarely. We recently designed B. pertussis and B. parapertussis experimental vaccines based on outer-membrane vesicles derived from each pathogen and obtained protection against the respective infections in mice. Here, we demonstrate that outer-membrane vesicles derived from virulent-phase B. bronchiseptica (OMVBbvir+) protect mice against sublethal infection from different B...
November 27, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29180031/will-we-have-new-pertussis-vaccines
#18
Camille Locht
Despite wide vaccination coverage with efficacious vaccines, pertussis is still not under control in any country. Two types of vaccines are available for the primary vaccination series, diphtheria/tetanus/whole-cell pertussis and diphtheria/tetanus/acellular pertussis vaccines, in addition to reduced antigen content vaccines recommended for booster vaccination. Using these vaccines, several strategies are being explored to counter the current pertussis problems, including repeated vaccination, cocoon vaccination and maternal immunization...
November 24, 2017: Vaccine
https://www.readbyqxmd.com/read/29177407/a-two-centre-randomised-trial-of-an-additional-early-dose-of-measles-vaccine-effects-on-mortality-and-measles-antibody-levels
#19
Ane B Fisker, Eric Nebie, Anja Schoeps, Cesario Martins, Amabelia Rodrigues, Alphonse Zakane, Moubassira Kagone, Stine Byberg, Sanne M Thysen, Justin Tiendrebeogo, Boubacar Coulibaly, Osman Sankoh, Heiko Becher, Hilton C Whittle, Fiona R M van der Klis, Christine S Benn, Ali Sie, Olaf Müller, Peter Aaby
Background: Besides protecting against measles, measles vaccine (MV) may have beneficial non-specific effects. We tested the effect of an additional early MV on mortality and measles antibody levels. Methods: Children aged 4-7 months in two rural health and demographic surveillance sites in Burkina Faso and Guinea-Bissau were randomised 1:1 to an extra early standard dose of MV (Edmonston-Zagreb strain) or no extra MV 4 weeks after the third diphtheria-tetanus-pertussis-hepatitis B-Haemophilus-influenzae-type-b vaccine...
November 21, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29174081/tdap-vaccination-among-healthcare-personnel-21-states-2013
#20
Alissa C O'Halloran, Peng-Jun Lu, Sarah A Meyer, Walter W Williams, Pamela K Schumacher, Aaron L Sussell, Jan E Birdsey, Winifred L Boal, Marie Haring Sweeney, Sara E Luckhaupt, Carla L Black, Tammy A Santibanez
INTRODUCTION: Outbreaks of pertussis can occur in healthcare settings. Vaccinating healthcare personnel may be helpful in protecting healthcare personnel from pertussis and potentially limiting spread to others in healthcare settings. METHODS: Data from 21 states using the 2013 Behavioral Risk Factor Surveillance System industry/occupation module were analyzed in 2016. Tetanus, diphtheria, and acellular pertussis (Tdap) vaccination status was self-reported by healthcare personnel along with their occupation, healthcare setting/industry, demographics, and access to care factors...
November 16, 2017: American Journal of Preventive Medicine
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