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Pertussis vaccines

Anaïs Thiriard, Dominique Raze, Camille Locht
The complement cascade participates in protection against bacterial infection and pathogens, including Bordetella pertussis, have developed complement-evading strategies. Here we discuss current knowledge on B. pertussis complement evasion strategies and the role of antibody-dependent complement-mediated killing in protection against B. pertussis infection pointing out important knowledge gaps for further research to improve current pertussis vaccines.
February 14, 2018: Microbes and Infection
P Latasa, L García-Comas, A Gil de Miguel, M D Barranco, I Rodero, J C Sanz, M Ordobás, A Arce, M Garrido-Estepa
INTRODUCTION: Pertussis is a communicable disease that primarily affects infants. Vaccination has led to an important reduction in the incidence of the disease, however, resurgence of the disease has been observed. This study aimed to analyze the incidence of pertussis and assess the vaccination effectiveness (VE) of different schedules of acellular pertussis vaccination in the community of Madrid. METHODS: Pertussis cases notified to the Mandatory Disease Reporting System from 1998 to 2015 were analyzed...
February 10, 2018: Vaccine
Scott A Halperin, Catherine Donovan, Gary S Marshall, Vitali Pool, Michael D Decker, David R Johnson, David P Greenberg
Background: Reduced-antigen-content tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is recommended in many countries for boosting immunity in adolescents and adults. Although immunity to these antigens wanes with time, currently available Tdap products are not labeled for repeat administration in the United States. Methods: We performed an observer-blinded, randomized controlled trial in 1330 adults aged 18 to <65 years who received either the Tdap (n = 1002) or tetanus-diphtheria (Td) (n = 328) vaccine 8 to 12 years after a dose of Tdap vaccine administered previously...
February 8, 2018: Journal of the Pediatric Infectious Diseases Society
Anne-Sophie Debrie, Loïc Coutte, Dominique Raze, Frits Mooi, Frances Alexander, Andrew Gorringe, Nathalie Mielcarek, Camille Locht
Pertussis or whooping cough is currently the most prevalent vaccine-preventable childhood disease despite >85% global vaccination coverage. In recent years incidence has greatly increased in several high-income countries that have switched from the first-generation, whole-cell vaccine to the newer acellular vaccines, calling for improved vaccination strategies with better vaccines. We have developed a live attenuated pertussis vaccine candidate, called BPZE1, which is currently in clinical development. Unlike other pertussis vaccines, BPZE1 has been shown to provide strong protection against infection by the causative agent of pertussis, Bordetella pertussis, in non-human primates...
February 9, 2018: Vaccine
Francesco Di Nardo, Sara Boccalini, Giovanna Elisa Calabrò, Andrea Marcellusi, Matteo Ruggeri, Paolo Bonanni, Raffaella Vitali, Eleonora Capannini, Francesco Saverio Mennini, Americo Cicchetti, Donatella Panatto, Roberto Gasparini, Walter Ricciardi, Chiara De Waure
INTRODUCTION: Decision-making in healthcare should rely on evidence-based approaches able to make possible a transparent and robust assessment of all the aspects related to health technologies. One of the assessment elements is represented by the efficiency that is the specific objective of economic evaluations and also of Health Technology Assessment (HTA). The collection and synthesis of evidence is the first indispensable step in order to foster a proper convey of scientific knowledge to the decision-makers...
September 2017: Igiene e Sanità Pubblica
Alberto Villani, Elena Bozzola, Anna Chiara Vittucci, Chiara Di Camillo, Laura Lancella, Andrzej Krzysztofiak, Luciana Nicolosi, Rocco Russo
The failure of immunization coverage is the primary reason for the transmission and the spread of the diseases in young infants not eligible for vaccination because of age and in immunocompromised individuals. In both these categories measles, pertussis and varicella could be devastating. Pertussis, measles and varicella in the first year of life are responsible to the ED admission, the hospitalization and, exceptionally, the death. The only way to protect very young infants and immunocompromised individuals is to obtain the adequate coverage in all the population...
September 2017: Igiene e Sanità Pubblica
Angela Gentile, María Del Valle Juarez, María Florencia Lucion, Ana Clara Martínez, Viviana Romanin, Soledad Areso, Alicia Mistchenko
INTRODUCTION: Whooping cough continues to be a major cause of morbidity and mortality in infants younger than 1 year. In 2012, Argentina introduced Tdap in pregnancy to prevent infant mortality. The aim of this study is to describe the impact of maternal immunization on the hospitalization and mortality rates of confirmed Bordetella pertussis (Bp) cases by comparing pre- and post-Tdap vaccine recommendation periods. MATERIAL AND METHODS: All PCR-confirmed Bp cases from "R...
February 8, 2018: Vaccine
Patrizio Pezzotti, Stefania Bellino, Francesca Prestinaci, Simone Iacchini, Francesca Lucaroni, Laura Camoni, Maria Maddalena Barbieri, Walter Ricciardi, Paola Stefanelli, Giovanni Rezza
BACKGROUND: Vaccination has determined a dramatic decline in morbidity and mortality from infectious diseases over the last century. However, low perceived risk of the infectious threat and increased concern about vaccines' safety led to a reduction in vaccine coverage, with increased risk of disease outbreaks. METHODS: Annual surveillance data of nationally communicable infectious diseases in Italy between 1900 and 2015 were used to derive trends in morbidity and mortality rates before and after vaccine introduction, focusing particularly on the effect of vaccination programs...
February 7, 2018: Vaccine
Nasamon Wanlapakorn, Kirsten Maertens, Surasith Chaithongwongwatthana, Donchida Srimuan, Narissara Suratannon, Sompong Vongpunsawad, Thao Mai Phuong Tran, Niel Hens, Pierre Van Damme, Camille Locht, Yong Poovorawan, Elke Leuridan
INTRODUCTION: Pregnant Thai women have low antibody titers against B. pertussis antigens, which coincide with an increasing incidence of pertussis among Thai infants. Thus, there exists a potential benefit of a booster dose of tetanus- diphtheria-acellular pertussis (Tdap) vaccine administered during pregnancy. Here, we report the vaccine reactogenicity profile and birth outcomes in Tdap-vaccinated pregnant women who have or have not had prior immunization with tetanus vaccine, and the IgG levels to B...
February 6, 2018: Vaccine
Cristina Giambi, Martina Del Manso, Teresa Dalla Zuanna, Flavia Riccardo, Antonino Bella, Maria Grazia Caporali, Agoritsa Baka, Nuska Caks-Jager, Tanya Melillo, Ricardo Mexia, Goranka Petrović, Silvia Declich
Over the last three years an unprecedented flow of migrants arrived in Europe. There is evidence that vaccine preventable diseases have caused outbreaks in migrant holding centres. These outbreaks can be favored by a combination of factors including low immunization coverage, bad conditions that migrants face during their exhausting journey and overcrowding within holding facilities. In 2017, we conducted an online survey in Croatia, Greece, Italy, Malta, Portugal and Slovenia to explore the national immunization strategies targeting irregular migrants, refugees and asylum seekers...
February 6, 2018: Vaccine
Lan Lin, Mercedes Macias Parra, Victor Y Sierra, Albino Salas Cespedes, Maria Angelica Granados, Adriana Luque, Silvia Damaso, Maria Mercedes Castrejon Alba, Luis Romano-Mazzotti, Frank Struyf
BACKGROUND: The burden of cervical cancer caused by human papillomavirus (HPV) is high in Latin America. The suboptimal HPV vaccination coverage in adolescents could be improved by pediatric immunization. HPV vaccination has not yet been reported in girls aged <9 years. METHODS: This ongoing phase III, controlled, randomized, single-blind, multicenter study conducted in Colombia, Mexico and Panama (NCT01627561) evaluated the safety and immunogenicity of AS04-HPV-16/18 vaccine in 4-6-year-old girls...
February 7, 2018: Pediatric Infectious Disease Journal
Luz Maria Vilca, Cristina Martínez, Miriam Burballa, Magda Campins
Objective Maternal care providers (MCPs), obstetrician-gynaecologists and midwives are uniquely placed to increase maternal vaccination acceptance. We aimed to assess their knowledge, attitudes and practices regarding influenza and pertussis vaccination during pregnancy. Methods We conducted an online survey among MCPs working at "Attention to Sexual and Reproductive Health" (ASSIR) Units in Catalonia region. The survey included questions about current recommendations of influenza and pertussis immunization during pregnancy, reasons for not routinely recommending vaccination and several strategies to increase vaccination uptake...
February 7, 2018: Maternal and Child Health Journal
Saskia van der Lee, Lotte H Hendrikx, Elisabeth A M Sanders, Guy A M Berbers, Anne-Marie Buisman
Introduction: Pertussis is re-emerging worldwide, despite effective immunization programs for infants and children. Epidemiological studies show a more limited duration of protection against clinical pertussis in adolescents primed with acellular pertussis (aP) vaccines during infancy than those who have been primed with whole-cell pertussis (wP) vaccines. This study aimed to determine whether memory immune responses to aP, diphtheria, and tetanus vaccine antigens following booster vaccinations at 4 and 9 years of age differ between wP- versus aP-primed children...
2018: Frontiers in Immunology
Martin Giera, Filipe Branco Dos Santos, Gary Siuzdak
Metabolomics combined with systems biology can be used to identify endogenous metabolites that modulate protein expression. Recent examples include the 2-fold enhancements of pertussis toxin protein in vaccine production and myelin basic protein expression in oligodendrocyte maturation; both applied a metabolomics-systems strategy to identify active metabolites.
February 6, 2018: Cell Metabolism
Ana Paula Sayuri Sato, Vinícius Leati de Rossi Ferreira, Márcia de Cantuária Tauil, Laura Cunha Rodrigues, Mariana Bernardes Barros, Edmar Martineli, Ângela Aparecida Costa, Marta Inenami, Eliseu Alves Waldman
OBJECTIVE: To describe adverse events following vaccination (AEFV) of children under two years old and analyze trend of this events from 2000 to 2013, in the city of Araraquara (SP), Brazil. METHODS: This is a descriptive study conducted with data of the passive surveillance system of AEFV that is available in the electronic immunization registry (EIR) of the computerized medical record of the municipal health service (Juarez System). The study variables were: age, gender, vaccine, dose, clinical manifestations and hospitalization...
February 5, 2018: Revista de Saúde Pública
R H M Raeven, J Brummelman, J L A Pennings, L van der Maas, K Helm, W Tilstra, A van der Ark, A Sloots, P van der Ley, W van Eden, W Jiskoot, E van Riet, C A C M van Els, G F A Kersten, W G H Han, B Metz
This corrects the article DOI: 10.1038/mi.2017.81.
February 7, 2018: Mucosal Immunology
NMdu Plessis, G Ntshoe, G Reubenson, R Kularatne, L Blumberg, J Thomas, T Avenant
BACKGROUND: In low and middle-income countries, including South Africa, the epidemiology of pertussis in relation to immunisation, nutritional and HIV status is poorly described. We report on risk factors in South African children hospitalised with pertussis. METHODS: We conducted a prospective, hospital-based, sentinel surveillance programme for pertussis in Gauteng Province, South Africa. Hospitalised children (≤10 years) meeting the surveillance criteria for clinically suspected pertussis were screened and enrolled...
February 1, 2018: International Journal of Infectious Diseases: IJID
Qing-Hong Meng, Jie Luo, Fan Yang, Ying-Jie Shen, Li Li, Li-Jun Li, Wei Shi, Ya-Juan Wang, Kai-Hu Yao
BACKGROUND: To investigate the level of pertussis-related antibodies in pregnant women and newborns. METHODS: A total of 286 serum samples from healthy pregnant women and 221cord samples from newborns were collected in 2016 in Beijing. A routinely blood sample from pregnant women was obtained at 35 weeks of gestational age, and cord samples were collected in 20 min after delivery. The values from cord samples were used as the infant values. Anti-pertussis toxin (PT) IgG concentration was measured by ELISA (Euroimmun, Lübeck, Germany) using purified PT as a coating antigen...
February 5, 2018: Pediatric Infectious Disease Journal
Jamie Koerner, Alicia B Forinash, Abigail M Yancey, Jessica Brinkmeyer, Spencer Dingman, Collin Miller, Judy Thompson, Laura Bergin, Julia D López, Amy Ravin
BACKGROUND: Infants younger than 6 months of age are at high risk for contracting pertussis because of not being fully vaccinated. The Advisory Committee on Immunization Practices (ACIP) recommends vaccinating all pregnant women with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap) between 27 and 36 weeks to offer passive immunity to the infant to help protect them until they are able to receive the full pertussis series. OBJECTIVE: To assess and compare compliance with the 2013 ACIP recommendation of vaccinating pregnant women with Tdap at 27 to 36 weeks' gestation in 2 obstetric clinics...
February 1, 2018: Annals of Pharmacotherapy
Sukhyun Ryu, Joon Jai Kim, Meng-Yu Chen, Hyunju Jin, Hyun Kyung Lee, Byung Chul Chun
Purpose: A pertussis patient from an elementary school, in Gyeonggi Province, Korea, was notified to public health authority on July 25, 2017. Epidemiologic investigation was conducted to identify the magnitude, possible source of infection and risk factors for this outbreak on August 17, 2017. Materials and Methods: A case was defined as the school student experiencing cough for more than two weeks with or without paroxysmal, whoop, or post-tussive vomiting. Control was defined as the student polymerase chain reaction-negative at the school...
January 2018: Clinical and Experimental Vaccine Research
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