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Hillegonda A Stallinga, Pieter U Dijkstra, Huib Ten Napel, Gabriël Roodbol, Jeroen W B Peters, Yvonne F Heerkens, Petrie F Roodbol
The Master program of Advanced Nursing Practice (MANP) educates nurses to become a nurse practitioner. Nurse practitioners are health care professionals focusing on the intersection of cure and care. However, a clear model covering that area is lacking. The use of the International Classification of Functioning, Disability and Health (ICF) may be considered for incorporation in curricula due to its focus on the integration of cure and care. The purpose of this study is to test the effects of a short (= 4-h instructor-led) ICF training on perceived usefulness of the ICF...
September 11, 2018: Nurse Education in Practice
Don C Des Jarlais, K Arasteh, J Feelemyer, C McKnight, David M Barnes, David C Perlman, A Uuskula, H L F Cooper, Susan Tross
OBJECTIVE: Assess hepatitis C virus (HCV) prevalence and incidence among person who began injecting drugs during the opioid epidemic in New York City (NYC) and identify possible new directions for reducing HCV infection among persons who inject drugs. METHODS: 846 persons who began injecting drugs between 2000 and 2017 were recruited from persons entering Mount Sinai Beth Israel substance use treatment programs. A structured interview was administered and HCV antibody testing conducted...
September 12, 2018: Drug and Alcohol Dependence
Philip H Chao, Mark Lazari, Sebastian Hanet, Maruthi Kumar Narayanam, Jennifer M Murphy, R Michael van Dam
Concentration of [18 F]fluoride has been mentioned in literature, however, reports have lacked details about system designs, operation, and performance. Here, we describe in detail a compact, fast, fully-automated concentration system based on a micro-sized strong anion exchange cartridge. The concentration of radionuclides enables scaled-up microfluidic synthesis. Our system can also be used to provide highly concentrated [18 F]fluoride with minimal water content. We demonstrate how the concentrator can produce varying concentrations of [18 F]fluoride for the macroscale synthesis of N-boc-5-[18 F]fluoroindole without an azeotropic drying process, while enabling high starting radioactivity...
June 23, 2018: Applied Radiation and Isotopes
Sabrina H Tsang, Samuel F Peisch, Brendan Rowan, Sarah C Markt, Amparo G Gonzalez-Feliciano, Siobhan Sutcliffe, Elizabeth A Platz, Lorelei A Mucci, Ericka M Ebot
We previously observed a positive association between seropositivity for the parasite Trichomonas vaginalis and risk of clinically significant prostate cancer at diagnosis. Here, we examined whether T. vaginalis seropositivity was associated with increased prostate cancer-specific or all-cause mortality among prostate cancer patients. We studied 749 men with prostate cancer from the Physicians' Health Study (PHS) and 736 men with prostate cancer from the Health Professionals Follow-Up Study (HPFS). We used Cox proportional hazard models to estimate multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between T...
September 22, 2018: International Journal of Cancer. Journal International du Cancer
Gregory J Moran, Carisa De Anda, Anita F Das, Sinikka Green, Purvi Mehra, Philippe Prokocimer
INTRODUCTION: Injection drug users (IDUs) often develop acute bacterial skin and skin structure infections (ABSSSI) and use emergency departments as their primary source for medical care. METHODS: A post hoc subgroup analysis of two randomized trials examined the efficacy and safety of tedizolid in the treatment of ABSSSI in IDUs. IDUs (n = 389) were identified from two pooled phase 3 trials (NCT01170221, NCT01421511) in patients with ABSSSI (n = 1333). Patients were randomly assigned to tedizolid phosphate (200 mg once daily, 6 days) or linezolid (600 mg twice daily, 10 days)...
September 21, 2018: Infectious Diseases and Therapy
Karlijn F M Denissen, Annelies Boonen, Johannes T H Nielen, Anouk L Feitsma, Ellen G H M van den Heuvel, Pieter J Emans, Coen D A Stehouwer, Simone J S Sep, Martien C J M van Dongen, Pieter C Dagnelie, Simone J P M Eussen
PURPOSE: Observational studies showed inverse associations between milk consumption and knee osteoarthritis (knee OA). There is lack of information on the role of specific dairy product categories. We explored the association between dairy consumption and the presence of knee osteoarthritis in 3010 individuals aged 40-75 years participating in The Maastricht Study. METHODS: The presence of knee OA was defined according to a slightly modified version of the American College of Rheumatology (ACR) clinical classification criteria...
September 21, 2018: European Journal of Nutrition
N Kirsten, K Herberger, M Augustin, W Tigges, C Behrendt, F Heidemann, E S Debus, H Diener
According to the Research Group for Primary Medical Care (PMV), approximately 890,000 people in Germany were suffering from a chronic wound in 2012. This corresponds to a prevalence of 1.1%. Ulcus cruris, diabetic ulcers and decubital ulcers are among the most frequent causes of chronic wounds (57-80%). The guarantee for successful wound care is based on a good understanding of the physiology of the wound healing process. A disorder of the phase-like course can lead to complications, delays or suspension of wound healing...
September 21, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
D Elias, H Vever, A-V Lænkholm, M F Gjerstorff, C W Yde, A E Lykkesfeldt, H J Ditzel
Since the online publication of the above article, the authors have noted errors in subfigures 1c and 3b. Therefore, new images of the original immmunocytochemistry stainings have been obtained for Fig. 1c, and the Western blots for siRNA-mediated FYN knockdown in Fig. 3b were repeated. The amended versions of Figs. 1c and 3b are now provided.
September 21, 2018: Oncogene
Karolina A Aberg, Brian Dean, Andrey A Shabalin, Robin F Chan, Laura K M Han, Min Zhao, Gerard van Grootheest, Lin Y Xie, Yuri Milaneschi, Shaunna L Clark, Gustavo Turecki, Brenda W J H Penninx, Edwin J C G van den Oord
We present the first large-scale methylome-wide association studies (MWAS) for major depressive disorder (MDD) to identify sites of potential importance for MDD etiology. Using a sequencing-based approach that provides near-complete coverage of all 28 million common CpGs in the human genome, we assay methylation in MDD cases and controls from both blood (N = 1132) and postmortem brain tissues (N = 61 samples from Brodmann Area 10, BA10). The MWAS for blood identified several loci with P ranging from 1...
September 21, 2018: Molecular Psychiatry
Hengyi Cao, Oliver Y Chén, Yoonho Chung, Jennifer K Forsyth, Sarah C McEwen, Dylan G Gee, Carrie E Bearden, Jean Addington, Bradley Goodyear, Kristin S Cadenhead, Heline Mirzakhanian, Barbara A Cornblatt, Ricardo E Carrión, Daniel H Mathalon, Thomas H McGlashan, Diana O Perkins, Aysenil Belger, Larry J Seidman, Heidi Thermenos, Ming T Tsuang, Theo G M van Erp, Elaine F Walker, Stephan Hamann, Alan Anticevic, Scott W Woods, Tyrone D Cannon
Understanding the fundamental alterations in brain functioning that lead to psychotic disorders remains a major challenge in clinical neuroscience. In particular, it is unknown whether any state-independent biomarkers can potentially predict the onset of psychosis and distinguish patients from healthy controls, regardless of paradigm. Here, using multi-paradigm fMRI data from the North American Prodrome Longitudinal Study consortium, we show that individuals at clinical high risk for psychosis display an intrinsic "trait-like" abnormality in brain architecture characterized as increased connectivity in the cerebello-thalamo-cortical circuitry, a pattern that is significantly more pronounced among converters compared with non-converters...
September 21, 2018: Nature Communications
Ilse M Rood, Jeroen K J Deegens, Dorien Lugtenberg, Ernie M H F Bongers, Jack F M Wetzels
Mutations in the NPHS2 gene, which encodes the podocyte slit diaphragm protein podocin, cause autosomal recessive steroid-resistant nephrotic syndrome (Online Mendelian Inheritance in Man [OMIM] #600995). Basic research and clinical studies have provided important insights about genotype-phenotype correlations. This knowledge allows personalized genetic (risk) counseling and should lead to changes in the advice given to patients. A patient who carries the R229Q variant (which has a high allele frequency of 3...
September 18, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Renan Akio Motoshima, Tainara da F Rosa, Léia da C Mendes, Estefânia Viana da Silva, Sthefany R F Viana, Bruno Sérgio do Amaral, Dulce H F de Souza, Luciano M Lião, Maria de Lourdes Corradi da Silva, Lorena R F de Sousa, Elaine R Carbonero
The inhibition of arginase from Leishmania spp. is considered a promising approach to the leishmaniasis treatment. In this study, the potential of a fucogalactan isolated from the medicinal mushroom Agrocybe aegerita was evaluated against arginase (ARG) from Leishmania amazonensis. The polysaccharide was obtained via aqueous extraction, and purified by freeze thawing and precipitation with Fehling solution. Its chemical structure was established by monosaccharide composition, methylation analysis, partial acid hydrolysis, and NMR spectroscopy...
December 1, 2018: Carbohydrate Polymers
Stephanie F Polites, Jennifer M Leonard, Amy E Glasgow, Martin D Zielinski, Donald H Jenkins, Elizabeth B Habermann
INTRODUCTION: Severely injured patients should receive definitive care at high acuity trauma centers. The purposes of this study were to determine the undertriage (UT) rate within a national sample of trauma centers and to identify characteristics of UT patients. METHODS: Severely injured adults ≥16 years were identified from the 2010-2012 NTDB. UT was defined as those who received definitive care or died at hospitals without state or ACS level I or II verification...
September 14, 2018: American Journal of Surgery
F A Kotasidis, G I Angelis, J M Anton-Rodriguez, H Zaidi
OBJECTIVE: Dynamic PET imaging is extensively used in brain imaging to estimate parametric maps. Inter-frame motion can substantially disrupt the voxel-wise time-activity curves (TACs), leading to erroneous maps during kinetic modelling. Therefore, it is important to characterize the robustness of kinetic parameters under various motion and kinetic model related factors. METHODS: Fully 4D brain simulations ([15 O]H2 O and [18 F]FDG dynamic datasets) were performed using a variety of clinically observed motion patterns...
September 2018: Physica Medica: PM
Tony K C Yung, Jean H Kim, Sing-Fai Leung, Rebecca M W Yeung, Annette N Y Poon, Edmond W C Au, Joseph T F Lau
OBJECTIVE: Restrictive food avoidance behavior among Chinese cancer patients is common. Yet, to the authors' knowledge, no study has investigated factors associated with such behavior. This study attempted to validate a new measurement tool, the Cancer Patients Food Avoidance Behaviors Scale (CPFAB), that assessed cancer patients' belief regarding 5 perceived benefits of practicing food avoidance, and to test its applicability. DESIGN: Cross-sectional face-to-face interviews...
September 18, 2018: Journal of Nutrition Education and Behavior
Guido Simonelli, Giannina Bellone, Diego Golombek, Daniel Pérez Chada, Nick Glozier, Vincent F Capaldi, Daniel E Vigo, Meir H Kryger
OBJECTIVES: To describe the hours of service provisions in continental Latin America. DESIGN: Information on regulations of service hours was extracted from either the national transportation authorities or ministries of transportation (or the equivalent institution) from each country. SETTING: Seventeen sovereign countries in continental Latin America (Argentina, Bolivia, Brazil, Chile, Colombia, Costa Rica, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Nicaragua, Panama, Paraguay, Peru, Uruguay, Venezuela)...
October 2018: Sleep Health
Charles K F Chan, Gunsagar S Gulati, Rahul Sinha, Justin Vincent Tompkins, Michael Lopez, Ava C Carter, Ryan C Ransom, Andreas Reinisch, Taylor Wearda, Matthew Murphy, Rachel E Brewer, Lauren S Koepke, Owen Marecic, Anoop Manjunath, Eun Young Seo, Tripp Leavitt, Wan-Jin Lu, Allison Nguyen, Stephanie D Conley, Ankit Salhotra, Thomas H Ambrosi, Mimi R Borrelli, Taylor Siebel, Karen Chan, Katharina Schallmoser, Jun Seita, Debashis Sahoo, Henry Goodnough, Julius Bishop, Michael Gardner, Ravindra Majeti, Derrick C Wan, Stuart Goodman, Irving L Weissman, Howard Y Chang, Michael T Longaker
Stem cell regulation and hierarchical organization of human skeletal progenitors remain largely unexplored. Here, we report the isolation of a self-renewing and multipotent human skeletal stem cell (hSSC) that generates progenitors of bone, cartilage, and stroma, but not fat. Self-renewing and multipotent hSSCs are present in fetal and adult bones and can also be derived from BMP2-treated human adipose stroma (B-HAS) and induced pluripotent stem cells (iPSCs). Gene expression analysis of individual hSSCs reveals overall similarity between hSSCs obtained from different sources and partially explains skewed differentiation toward cartilage in fetal and iPSC-derived hSSCs...
September 20, 2018: Cell
Y S Basmaeil, A M Al Subayyil, T Khatlani, E Bahattab, M Al-Alwan, F M Abomaray, B Kalionis, M A Alshabibi, A S AlAskar, M H Abumaree
BACKGROUND: Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2 O2 ). In diabetes, elevated levels of glucose (hyperglycaemia) induce H2 O2 production, which causes the endothelial dysfunction that underlies the enhanced immune responses and adverse complications associated with diabetes, which leads to thrombosis and atherosclerosis. In this study, we examined the ability of pMSCs to protect endothelial cell functions from the negative impact of high level of glucose...
September 21, 2018: Stem Cell Research & Therapy
Najeba F Salih
This study entails the measurement of the specific activity of natural radionuclides (226 Ra, 40 K and 232 Th) in 18 tooth samples obtained from the clinic of the Universiti Sains Malaysia (USM), Penang, by using an HPGe detector. The specific activity of 226 Ra, 40 K and 232 Th was measured to estimate the hazard index of the radionuclides, radium equivalent activities (Raeq ), external, internal hazard indices (Hex , Hin ), and absorbed dose (Dout , Din ). The maximum values of concentration of 226 Ra, 232 Th and 40 K in the tooth samples were found to be 60...
September 21, 2018: Isotopes in Environmental and Health Studies
Luanda B F C Souza, Walicyranison P Silva-Rocha, Magda R A Ferreira, Luiz Alberto L Soares, Terezinha I E Svidzinski, Eveline P Milan, Regina H Pires, Ana Marisa Fusco Almeida, Maria José S Mendes-Giannini, Guilherme Maranhão Chaves
This study evaluated the influence of the extract of Eugenia uniflora in adhesion to human buccal epithelial cells (HBEC) biofilm formation and cell surface hydrophobicity (CSH) of Candida spp. isolated from the oral cavity of kidney transplant patients. To evaluate virulence attributes in vitro, nine yeasts were grown in the presence and absence of 1000 μg/mL of the extract. Adhesion was quantified using the number of Candida cells adhered to 150 HBEC determined by optical microscope. Biofilm formation was evaluated using two methodologies: XTT (2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2 H -tetrazolium-5-carboxanilide) and crystal violet assay, and further analyzed by electronic scan microscopy...
September 20, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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