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https://www.readbyqxmd.com/read/29775846/reproductive-stage-and-sex-steroid-hormone-levels-influence-the-expression-of-mesenchymal-stromal-cell-msc-markers-in-the-equine-endometrium
#1
B Elisabeth Rink, Juliane Kuhl, Cristina L Esteves, Hilari M French, Elaine Watson, Christine Aurich, F Xavier Donadeu
Mesenchymal stem or stromal cells (MSCs) play key roles in tissue homeostasis. In the cyclic equine endometrium, this may be regulated by changes in serum concentrations of sex steroid hormones. This study was designed to investigate the changes in endometrial expression of MSC markers during reproductive cycles in mares and the influence of sex steroid hormones on endometrial MSC proliferation in vitro. Endometrial biopsies were collected from pony mares at different reproductive stages (estrus; day 5 and 13 after ovulation; seasonal anestrus; 20 h and 7days post-partum; n = 5 per stage) and were analyzed by RT-qPCR...
May 4, 2018: Theriogenology
https://www.readbyqxmd.com/read/29775842/retention-of-neodymium-by-dolomite-at-variable-ionic-strength-as-probed-by-batch-and-column-experiments
#2
H P Emerson, F Zengotita, M Richmann, Y Katsenovich, D T Reed, T M Dittrich
The results presented in this paper highlight the complexity of adsorption and incorporation processes of Nd with dolomite and significantly improve upon previous work investigating trivalent actinide and lanthanide interactions with dolomite. Both batch and mini column experiments were conducted at variable ionic strength. These data highlight the strong chemisorption of Nd to the dolomite surface (equilibrium Kd 's > 3000 mL/g) and suggest that equilibrium adsorption processes may not be affected by ionic strength based on similar results at 0...
May 15, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29775769/quality-of-life-after-combined-endonasal-endoscopic-odontoidectomy-and-posterior-suboccipital-decompression-and-fusion
#3
Malte Ottenhausen, Andrew F Alalade, Kavelin Rumalla, Prakash Nair, Ali Baaj, Roger Hartl, Ashutosh Kacker, Jeffrey P Greenfield, Vijay K Anand, Theodore H Schwartz
INTRODUCTION: Basilar invagination can result from a variety of systemic diseases that can weaken the structural integrity of the craniocervical junction. Definitive treatment often requires ventral decompression along with posterior decompression and fusion. Endonasal odontoidectomy is a relatively new minimal access procedure, however, quality of life after this procedure has not been reported. METHODS: We reviewed a consecutive database of endonasal odontoidectomy patients and identified those having posterior decompression and fusion...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775704/alkaline-active-cyanide-dihydratase-of-flavobacterium-indicum-mtcc-6936-growth-optimization-purification-characterization-and-in-silico-analysis
#4
Virender Kumar, Vijay Kumar, Tek Chand Bhalla
The present work explores a rare cyanide dihydratase of Flavobacterium indicum MTCC 6936 for its potential of cyanide degradation. The enzyme is purified to 12 fold with a yield of 76%. SDS and native-PAGE analysis revealed that enzyme was monomer of 40 kDa size. The enzyme works well in mesophilic range at wide array of pH. The thermostability profile of cyanide dihydratase revealed that the enzyme is quite stable at 30 °C and 35 °C with half-life of 6 h 30 min and 5 h respectively. Km and Vmax for cyanide dihydratase of F...
May 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29775637/modified-resin-infiltration-of-non-micro-and-cavitated-proximal-caries-lesions-in-vitro
#5
H Askar, F Schwendicke, J Lausch, H Meyer-Lueckel, S Paris
OBJECTIVE: Infiltrant resin (IR) is currently indicated for non-cavitated caries lesions. However, modifying the technique might expand its indication spectrum to micro-cavitated lesions. The present study aimed to evaluate the penetration/filling ability of a newly developed micro-filled infiltrant resin (MFIR) in non-, micro- and cavitated natural caries lesions. MATERIALS AND METHODS: Proximal lesions in 120 extracted human teeth with ICDAS-2 (n = 30), 3 (n = 45) and 5 (n = 45) lesions were etched with 15% hydrochloric acid gel for 2 min and allocated to one of the following treatments; IR: lesions (ICDAS-2, 3 and 5; each n = 15) were treated with commercial infiltrant resin for 3 min...
May 15, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29775351/masses-and-%C3%AE-decay-spectroscopy-of-neutron-rich-odd-odd-160-162-eu-nuclei-evidence-for-a-subshell-gap-with-large-deformation-at-n-98
#6
D J Hartley, F G Kondev, R Orford, J A Clark, G Savard, A D Ayangeakaa, S Bottoni, F Buchinger, M T Burkey, M P Carpenter, P Copp, D A Gorelov, K Hicks, C R Hoffman, C Hu, R V F Janssens, J W Klimes, T Lauritsen, J Sethi, D Seweryniak, K S Sharma, H Zhang, S Zhu, Y Zhu
The structure of deformed neutron-rich nuclei in the rare-earth region is of significant interest for both the astrophysics and nuclear structure fields. At present, a complete explanation for the observed peak in the elemental abundances at A∼160 eludes astrophysicists, and models depend on accurate quantities, such as masses, lifetimes, and branching ratios of deformed neutron-rich nuclei in this region. Unusual nuclear structure effects are also observed, such as the unexpectedly low energies of the first 2^{+} levels in some even-even nuclei at N=98...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775346/faraday-shielded-dc-stark-shift-free-optical-lattice-clock
#7
K Beloy, X Zhang, W F McGrew, N Hinkley, T H Yoon, D Nicolodi, R J Fasano, S A Schäffer, R C Brown, A D Ludlow
We demonstrate the absence of a dc Stark shift in an ytterbium optical lattice clock. Stray electric fields are suppressed through the introduction of an in-vacuum Faraday shield. Still, the effectiveness of the shielding must be experimentally assessed. Such diagnostics are accomplished by applying high voltage to six electrodes, which are grounded in normal operation to form part of the Faraday shield. Our measurements place a constraint on the dc Stark shift at the 10^{-20} level, in units of the clock frequency...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775342/boundaries-control-collective-dynamics-of-inertial-self-propelled-robots
#8
A Deblais, T Barois, T Guerin, P H Delville, R Vaudaine, J S Lintuvuori, J F Boudet, J C Baret, H Kellay
Simple ingredients, such as well-defined interactions and couplings for the velocity and orientation of self-propelled objects, are sufficient to produce complex collective behavior in assemblies of such entities. Here, we use assemblies of rodlike robots made motile through self-vibration. When confined in circular arenas, dilute assemblies of these rods act as a gas. Increasing the surface fraction leads to a collective behavior near the boundaries: polar clusters emerge while, in the bulk, gaslike behavior is retained...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29775310/fragment-based-discovery-of-a-potent-orally-bioavailable-inhibitor-which-modulates-the-phosphorylation-and-catalytic-activity-of-erk1-2
#9
Tom D Heightman, Valerio Berdini, Hannah Braithwaite, Ildiko Maria Buck, Megan Cassidy, Juan Castro, Aurelie Courtin, James E H Day, Charlotte East, Lynsey Fazal, Brent Graham, Charlotte M Griffiths-Jones, John F Lyons, Vanessa Martins, Sandra Muench, Joanne M Munck, David Norton, Marc O'Reilly, Nick Palmer, Puja Pathuri, Michael Reader, David C Rees, Sharna J Rich, Caroline Richardson, Harpreet Saini, Neil T Thompson, Nicola G Wallis, Hugh Walton, Nicola E Wilsher, Alison J-A Woolford, Michael Cooke, David Cousin, Stuart Onions, Jonathan Shannon, John Watts, Christopher W Murray
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increased signalling through ERK1/2. Here we describe the fragment based generation of ERK1/2 inhibitors which block catalytic phosphorylation of downstream substrates such as RSK but also modulate phosphorylation of ERK1/2 by MEK without directly inhibiting MEK. X-ray crystallographic and biophysical fragment screening followed by structure-guided optimization and growth from the hinge into a pocket proximal to the C-α helix afforded highly potent ERK1/2 inhibitors with excellent kinome selectivity...
May 18, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29775302/free-base-nicotine-determination-in-electronic-cigarette-liquids-by-1-h-nmr-spectroscopy
#10
Anna K Duell, James F Pankow, David H Peyton
E-liquids usually contain significant nicotine, which will exist primarily in two forms, monoprotonated and free-base the proportions are alterable through the effective pH of the medium. The fraction of nicotine in the free-base form is αfb , with 0 < αfb < 1. When dosed via aerosol, the two nicotine forms have different mechanisms and kinetics of delivery, as well as differing implications for harshness of the inhaled aerosol, so αfb is relevant regarding abuse liability. Previous attempts to determine αfb in electronic cigarette liquids and vapor have been flawed...
May 18, 2018: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29775092/a-prospective-multi-centre-us-clinical-trial-to-determine-accuracy-of-febridx-point-of-care-testing-for-acute-upper-respiratory-infections-with-and-without-a-confirmed-fever
#11
Nathan I Shapiro, Wesley H Self, Jeffrey Rosen, Stephan C Sharp, Michael R Filbin, Peter C Hou, Amisha D Parekh, Michael C Kurz, Robert Sambursky
BACKGROUND: FebriDx is a 10-minute disposable point-of-care test designed to identify clinically significant systemic host immune responses and aid in the differentiation of bacterial and viral respiratory infection by simultaneously detecting C-reactive protein (CRP) and myxovirus resistance protein A (MxA) from a fingerstick blood sample. FebriDx diagnostic accuracy was evaluated in the emergency room and urgent care setting. METHODS: A prospective, multicentre, observational cohort study of acute upper respiratory tract infections (URIs), with and without a confirmed fever at the time of enrolment, was performed to evaluate the diagnostic accuracy of FebriDx to identify clinically significant bacterial infection with host response and acute pathogenic viral infection...
May 18, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29775049/bandgap-tunable-porous-borocarbonitrides-nanosheets-for-high-energy-density-supercapacitors
#12
Shouzhi Wang, Fukun Ma, Hehe Jiang, Yongliang Shao, Yongzhong Wu, Xiaopeng Hao
Bandgap tunable porous borocarbonitride (BCN) nanosheets were successfully fabricated with cheap and readily available precursors by annealing and exfoliating. The bandgap of the as-prepared BCN materials ranges from 5.5 eV to 1.0 eV, these samples exhibit beneficial structural features suitable for the application in supercapacitors (SCs). Especially, the BCN material with a bandgap of 1.0 eV exhibits great specific surface area (600.9 m2 g‒1), massive active sites and excellent conductivity (10.8 S m‒1)...
May 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29775043/designing-a-dy-2-single-molecule-magnet-with-two-well-differentiated-relaxation-processes-by-using-a-nonsymmetric-bis-bidentate-bipyrimidine-n-oxide-ligand-a-comparison-with-mononuclear-counterparts
#13
Ismael F Díaz-Ortega, Juan Manuel Herrera, Daniel Aravena, Eliseo Ruiz, Tulika Gupta, Gopalan Rajaraman, H Nojiri, Enrique Colacio
Herein we report a dinuclear [(μ-mbpymNO){(tmh)3 Dy}2 ] (1) single-molecule magnet (SMM) showing two nonequivalent DyIII centers, which was rationally prepared from the reaction of Dy(tmh)3 moieties (tmh = 2,2,6,6-tetramethyl-3,5-heptanedionate) and the asymmetric bis-bidentate bridging ligand 4-methylbipyrimidine (mbpymNO). Depending on whether the DyIII ions coordinate to the N^O or N^N bidentate donor sets, the DyIII sites present a NO7 ( D2 d geometry) or N2 O6 ( D4 d ) coordination sphere. As a consequence, two different thermally activated magnetic relaxation processes are observed with anisotropy barriers of 47...
May 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29775028/-diagnosis-and-treatment-of-atypical-angiofibromas-of-nose
#14
L F Wang, K P Li, H J Jin, S C Jin, J Z Sang
No abstract text is available yet for this article.
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775018/-causes-and-management-of-frontal-sinusitis-after-transfrontal-craniotomy
#15
T C Liu, X F Yu, Z W Gu, W L Bai, Z H Wang, Z W Cao
Objective: The aim of this study is to investigate the causes and the strategy of frontal sinusitis after transfrontal craniotomy by endoscopic frontal sinus surgery and traditional surgery with facial incision. Method: A total of thirty-four patients with frontal sinusitis after transfrontal craniotomy were admitted, with the symptom of purulence stuff, headache and upper eyelid discharging. The onset time was 2.6 years on average. The frontal sinus CT and MRI images showed frontal sinusitis. Twenty-seven patients were treated with endoscopic frontal sinus surgery, and seven patient was treated with combined endoscopic and traditional frontal sinus surgery...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775016/-effect-of-salvianolic-acid-b-on-proliferation-and-apoptosis-of-human-nasal-polyps-fibroblasts
#16
D Luo, Y X Zhao, Y H Zhang, Y Zhou, J Ding, Z F Sun
Objective: The aim of this study is to discuss the effects and mechanism of salvianolic acid B (SAB) on the proliferation and apoptosis of human nasal polyps fibroblasts (NPFs). Method: The NPFs were treated with SAB at different concentrations (5, 10, 20, 40 μmol/L). CCK-8 assay was used to determine the inhibition of SAB on the proliferation of NPFs and determined the optimum concentration for the following experiments. The NPFs were divided into four groups: a) control group: the cells were cultured in DMEM without TGF-β1 or salvianolic acid B; b) the TGF-β1 group: the cells were cultured in DMEM containing 5 ng/ml TGF-β1; c) the SAB group: the cells were cultured in DMEM containing SAB at the optimum concentration by CCK-8 assay; d) the TGF-β1+SAB treatment groups: the cells were cultured in DMEM containing 5 ng/ml TGF-β1 and SAB at the optimum concentration by CCK-8 assay...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775014/-the-application-of-3d-reconstruction-in-investigating-the-frontal-sinus-drainage-pathway-based-on-computer-tomography-data
#17
Y Liu, X Q Ma, X H Sun, S Dai, J F Zhang, H B Li, X Ma, J Y Wang, Q Dou, J Y Tian, J P Jia
Objective: The aim of this study is to explore the value of 3D reconstruction technology based on computer tomography data in understanding the frontal sinus drainage pathway. Method: Three-dimensional reconstruction of DICOM data from 100 cases of sinus CT was performed by using Mimics 19.0 software. The 3D models were used to study types, the relative locations of frontal sinus and recess cells as well as the influence of the frontal sinus drainage pathway. Result: The 3D model of frontal sinus, frontal recess cells and frontal sinus drainage pathway were reconstructed successfully...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775005/-determination-and-significance-of-serum-mpo-and-amylin-in-adult-patients-with-osahs-after-short-range-noninvasive-positive-pressure-ventilation
#18
X H Chen, P J Chen, Y Long, Q P Huang
Objective: The aim of this study to investigate the determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation. Method: Eighty-seven OSAHS patients were divided into severe group (30 cases), moderate group (30 cases) and mild group (27 cases) according to the AHI range. Twenty-seven outpatient health persons were selected as the control group. Serum amylin and myeloperoxidase were measured by ELISA; Amyloid and myeloperoxidase were reassessed in 30 patients with severe OSAHS after 6 months of combined therapy, and the relationship between amylin, myeloperoxidase and PSG was analyzed...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774996/-study-of-gonadotropin-releasing-hormone-on-suppressing-migrationg-and-invationg-of-human-nasopharyngeal-carcinoma-cells-cne2
#19
Y H Sun, T T Kong, T T Wang, H F Zhu, T W Zhuang, D P Wang
Objective: The aim of this study is to investigate the effect of gonadotropin releasing hormone (GnRH) on suppressing cell viability, apoptosis, migrationg and invationg of human nasopharyngeal carcinoma cells CNE2. Method: Nasopharyngeal carcinoma tissues and postnasal catarrh tissues were collected, the expression of GnRH positive cells and GnRH mRNA were detected by immunohistochemical staining and qRT-PCR. The human nasopharyngeal carcinoma CNE2 cells and immortalized nasopharyngeal epithelial cell line NP69 were cultured in vitro, and the expression of GnRH positive cells and GnRH mRNA were detected by immunohistochemical staining and qRT-PCR...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774987/an-increased-percentage-of-myeloid-cd34-bone-marrow-cells-stratifies-intermediate-ipss-r-myelodysplastic-syndrome-patients-into-prognostically-significant-groups
#20
T-H Chen-Liang, A M Casado-Prieto, V Campos-Rodríguez, A M Hurtado, M L Amigo, M D García-Malo, V Vicente, F J Ortuño, A Jerez
INTRODUCTION: The Revised International Prognostic Scoring System (IPSS-R) for myelodysplastic syndromes (MDS) has established an intermediate category where a disease-modifying intervention is a matter of debate. Flow cytometry allows us to determine a fraction of immature myeloid cells in a semiautomated procedure. The aim of this study, mirroring IPSS-R study inclusion criteria, was to test whether bone marrow (BM) CD34+My percentage has independent prognostic value in the MDS setting...
May 18, 2018: International Journal of Laboratory Hematology
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