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https://www.readbyqxmd.com/read/29920143/molecular-characterization-of-carbapenem-resistant-acinetobacter-baumannii-in-the-intensive-care-unit-of-uruguay-s-university-hospital-identifies-the-first-rmtc-gene-in-the-species
#1
Inés Bado, Romina Papa-Ezdra, Jose F Delgado-Blas, Micaela Gaudio, Claudia Gutiérrez, Nicolás F Cordeiro, Virginia García-Fulgueiras, Lucía Araújo Pirez, Verónica Seija, Julio C Medina, Gloria Rieppi, Bruno Gonzalez-Zorn, Rafael Vignoli
Carbapenem-resistant Acinetobacter baumannii (CRAB) infections are an increasing concern in intensive care units (ICUs) worldwide. The combination of carbapenemases and 16S rRNA-methyltransferases (16S-RMTases) further reduces the therapeutic options. OXA-carbapenemase/A. baumannii clone tandems in Latin America have already been described; however, no information exists in this region regarding the occurrence of 16S-RMTases in this microorganism. In addition, the epidemiology of A. baumannii in ICUs and its associated resistance profiles are poorly understood...
June 19, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29917237/the-extracellular-matrix-glycoprotein-tenascin-x-regulates-peripheral-sensory-and-motor-neurones
#2
Rubina Aktar, Madusha Peiris, Asma Fikree, Vincent Cibert-Goton, Maxim Walmsley, Iain R Tough, Paulo Watanabe, Eduardo J A Araujo, Sahar D Mohammed, Jean-Marie Delalande, David C Bulmer, S Mark Scott, Helen M Cox, Nicol C Voermans, Qasim Aziz, L Ashley Blackshaw
The extracellular matrix (ECM) is not only an integral structural molecule, but is also critical for a wide range of cellular functions. The glycoprotein tenascin-X (TNX) predominates in the ECM of tissues like skin and regulates tissue structure through anti-adhesive interactions with collagen. Monogenic TNX deficiency causes painful joint hypermobility and skin hyperelasticity, symptoms characteristic of hypermobility-Ehlers Danlos Syndrome (hEDS). hEDS patients also report consistently increased visceral pain and gastrointestinal (GI) dysfunction...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29915739/awareness-of-colorectal-cancer-among-public-in-asir-region
#3
Mohammad Nassir Al-Sharif, Khalid Ali Fayi, Abdulsalam Ali Alobaidi, Bader Awadh Alshamrani
Introduction: Colorectal cancer (CRC) has different forms of colon cancer or rectal cancer. CRCs are often considered together because they possess many similar features. A severe form of the disease with higher mortality rate increases with increase in age. The most common CRC risk factors include smoking, diabetes, and obesity. This study aims to evaluate the awareness of CRC in a random population of Asir region and to identify the subpopulation that can be recipients of awareness and screening programs...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29907462/learning-curve-of-robotic-rectal-surgery-with-lateral-lymph-node-dissection-cumulative-sum-and-multiple-regression-analyses
#4
Kazushige Kawai, Keisuke Hata, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Murono, Kazuhito Sasaki, Manabu Kaneko, Shigenobu Emoto, Hiroaki Nozawa
OBJECTIVE: This study aimed to assess the learning curve of robotic rectal surgery, a procedure that has gained increasing focus in recent years because it is expected that the advanced devices used in this approach provide advantages resulting in a shorter learning curve than that of laparoscopic surgery. However, no studies have assessed the learning curve of robotic rectal surgery, especially when lateral lymph node dissection is required. DESIGN: This was a nonrandomized, retrospective study from a single institution...
June 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29904490/rectal-lipoma-as-a-lead-point-for-colo-colonic-intussusception
#5
Farzaneh Shobeirian, Mersad Mehrnahad, Hossein Soleimantabar
Intussusception in adults is a rare condition and most of the time there is a pathologic lesion that serves as a leading point. Unless highly suspicious, intussusception causing chronic abdominal pain and obstructive symptoms are rarely diagnosed before the surgery. In this study, we report a colo-colonic intussusception in a 73-year-old man with an intraluminal rectal lipoma as the leading point.
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29901698/association-of-dietary-insulinemic-potential-and-colorectal-cancer-risk-in-men-and-women
#6
Fred K Tabung, Weike Wang, Teresa T Fung, Stephanie A Smith-Warner, NaNa Keum, Kana Wu, Charles S Fuchs, Frank B Hu, Edward L Giovannucci
Background: Insulin response may be important in colorectal cancer development. Diet modulates insulin response and may be a modifiable factor in colorectal cancer prevention. Objective: We examined associations between hyperinsulinemic diets and colorectal cancer risk with the use of an empirical dietary index for hyperinsulinemia (EDIH), a food-based index that characterizes dietary insulinemic potential on the basis of circulating C-peptide concentrations. Design: Diet was assessed every 4 y with food-frequency questionnaires in 46,210 men (Health Professionals Follow-Up Study, 1986-2012) and 74,191 women (Nurses' Health Study, 1984-2012) to calculate EDIH scores...
June 12, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29900052/time-tumor-immunity-in-the-microenvironment-classification-based-on-tumor-cd274-pd-l1-expression-status-and-tumor-infiltrating-lymphocytes-in-colorectal-carcinomas
#7
Tsuyoshi Hamada, Thing Rinda Soong, Yohei Masugi, Keisuke Kosumi, Jonathan A Nowak, Annacarolina da Silva, Xinmeng Jasmine Mu, Tyler S Twombly, Hideo Koh, Juhong Yang, Mingyang Song, Li Liu, Mancang Gu, Yan Shi, Katsuhiko Nosho, Teppei Morikawa, Kentaro Inamura, Sachet A Shukla, Catherine J Wu, Levi A Garraway, Xuehong Zhang, Kana Wu, Jeffrey A Meyerhardt, Andrew T Chan, Jonathan N Glickman, Scott J Rodig, Gordon J Freeman, Charles S Fuchs, Reiko Nishihara, Marios Giannakis, Shuji Ogino
Inhibitors targeting the PDCD1 (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor CD274 ( PDCD1 ligand 1, PD-L1) expression and tumor-infiltrating lymphocytes (TIL) has been proposed to predict response to immunotherapy. It remains to be determined clinical, pathological, and molecular features of TIME subtypes of colorectal cancer. Using 812 colon and rectal carcinoma cases from the Nurses' Health Study and Health Professionals Follow-up Study, we examined the association of tumor characteristics and survival outcomes with four TIME subtypes (TIME 1, CD274 low /TILabsent ; TIME 2, CD274 high /TILpresent ; TIME 3, CD274 low /TILpresent ; and TIME 4, CD274 high /TILabsent )...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29898664/an-unusual-diverticulum-adjacent-to-two-large-colonic-polyps-a-case-report
#8
John Schembri, Jonathan Bury, Lesley Hunt, Stuart Riley
BACKGROUND: Adenocarcinomas can arise in a variety of circumstances in which intestinal segments have been used for urinary diversions. Whereas ureterosigmoidostomy is the oldest and simplest form of continent urinary diversion it also seems to be the most dangerous in this regard. Herein we present a case of colonic neoplasia complicating a non-functioning ureterosigmoidostomy after 55 years; the longest latent period documented to date. CASE PRESENTATION: A 56-year-old lady born with congenital bladder exystrophy and who had a functional ileal conduit presented to us with a 6 month history of change in bowel habit and rectal bleeding...
June 14, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29896400/carcinoma-in-the-residual-rectum-of-a-long-standing-crohn-s-disease-patient-following-subtotal-colectomy-a-case-report
#9
Kazuaki Shibuya, Shigenori Homma, Tadashi Yoshida, Yosuke Ohno, Nobuki Ichikawa, Hideki Kawamura, Teppei Imamoto, Yoshihiro Matsuno, Akinobu Taketomi
The development of colorectal cancer in long-standing Crohn's disease (CD) patients has become a major complication. Therapeutic guidelines for CD-associated cancer (CDAC) have already been established in Western countries; however, specific guidelines are not currently available in Japan. Surveillance of the residual intestine for cancer screening is important for long-standing CD patients. The present case report describes the occurrence of rectal carcinoma in a patient with a 25-year history of CD. A 37-year-old male with a 17-year history of CD underwent semi-emergent subtotal colectomy and ileostomy for bowel obstruction secondary to the transverse colon stenosis, and multiple severe stenosis and inflammation...
July 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29895100/anastomotic-leaks-in-stage-iv-colorectal-cancer
#10
Suat Chin Ng, Douglas Stupart, David Bartolo, David Watters
BACKGROUND: The purpose of this study was to determine the anastomotic leak rate for colorectal cancer resections in patients with metastases (compared to those without), and to determine the impact of anastomotic leaks on survival. METHODS: This is a retrospective analysis of all patients who underwent resection and primary anastomosis for colorectal adenocarcinoma at a single institution between January 2002 and December 2014. RESULTS: A total of 843 patients underwent a resection and primary anastomosis for colorectal adenocarcinoma (661 colon and 182 rectal)...
June 12, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29894583/prognostic-value-and-characteristics-of-n1c-colorectal-cancer
#11
Morgane Bouquot, Ben Creavin, Nicolas Goasguen, Najim Chafai, Emmanuel Tiret, Thierry André, Jean-Francois Flejou, Yann Parc, Jérémie H Lefevre, Magali Svrcek
The presence of tumor deposits (TD) in colorectal cancer (CRC) is associated with poor prognosis. The 7th edition of TNM subclassified a new nodal stage, N1c, characterized by the presence of TD without any concurrent positive lymph node (LN). It is not clear if the N1c category is equal or not to LN metastasis. We aimed to examine the prevalence, characteristics and prognostic significance of this new subcategory METHODS: Consecutive patients who underwent surgery for CRC in two centers (2011-2014) were analyzed...
June 12, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29891594/risk-factors-for-gastrointestinal-colonization-and-acquisition-of-carbapenem-resistant-gram-negative-bacteria-among-patients-in-intensive-care-units-in-thailand
#12
Anong Kiddee, Kanit Assawatheptawee, Anamai Na-Udom, Pornpit Treebupachatsakul, Apirath Wangteeraprasert, Timothy R Walsh, Pannika R Niumsup
This study was conducted to investigate the prevalence and risk factors for carbapenem-resistant Gram-negative Bacteria (CR-GNB) colonization and acquisition among patients admitted to Intensive Care Units (ICUs) in two tertiary care hospitals in Northern Thailand. Rectal swab screening for CR-GNB was performed on patients at ICU admission and discharge. Phenotypes and genotypes of all isolates were determined. Risk factors were analyzed by logistic regression analysis. Overall, carriage rates of CR-GNB at admission was 11...
June 11, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29891525/weekend-effect-in-emergency-colon-and-rectal-cancer-surgery-a-prospective-study-using-data-from-the-dutch-colorectal-audit
#13
Daniëlle D Huijts, Julia T van Groningen, Onno R Guicherit, Jan Willem T Dekker, Leti van Bodegom-Vos, Esther Bastiaannet, Johannes A Govaert, Michel W Wouters, Perla J Marang-van de Mheen
Background: It is unclear whether emergency weekend colon and rectal cancer surgery are associated with worse outcomes (ie, weekend effect) because previous studies mostly used administrative data, which may insufficiently adjust for case-mix. Materials and Methods: Prospectively collected data from the 2012-2015 Dutch ColoRectal Audit (n=5,224) was used to examine differences in 30-day mortality and severe complication and failure-to-rescue rates for emergency weekend (Saturday and Sunday) versus Monday surgery, stratified for colon and rectal cancer...
June 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29887884/clinicopathologic-significance-of-cxcl12-and-cxcr4-expressions-in-patients-with-colorectal-cancer
#14
Naomi Yoshuantari, Didik Setyo Heriyanto, Susanna Hilda Hutajulu, Johan Kurnianda, Ahmad Ghozali
Background: Colorectal cancer (CRC) is both a global and national burden, being the third most common malignancy in men and the second in women, worldwide. The prognosis of CRC is affected by various factors like the histological grade, angiolymphatic invasion, and distant metastases. Metastasis is an intricate process; one of the possible mechanisms is through the interaction of the chemokines CXCL12 and CXCR4. This study aims to reveal the expression patterns of CXCL12 and CXCR4 in CRC...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29887882/colonic-mucosal-microbiota-in-colorectal-cancer-a-single-center-metagenomic-study-in-saudi-arabia
#15
Ahmed O Alomair, Ibrahim Masoodi, Essam J Alyamani, Abed A Allehibi, Adel N Qutub, Khalid N Alsayari, Musaad A Altammami, Ali S Alshanqeeti
Background and Aim: Because genetic and geographic variations in intestinal microbiota are known to exist, the focus of this study was to establish an estimation of microbiota in colorectal cancer (CRC) patients in Saudi Arabia by means of metagenomic studies. Methods: From July 2010 to November 2012, colorectal cancer patients attending our hospital were enrolled for the metagenomic studies. All underwent clinical, endoscopic, and histological assessment. Mucosal microbiota samples were collected from each patient by jet-flushing colonic mucosa with distilled water at unified segments of the colon, followed by aspiration, during colonoscopy...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29886588/-gastrointestinal-leiomyoma-with-interstitial-cells-of-cajal-mimicker-of-gastrointestinal-stromal-tumor
#16
G M Hu, Y K Feng, Q Y Liu, H P Chen, W J Fu, M Zhang, J Chang, B Gu, H F Wu, J L Ren
Objective: To study clinical and pathologic characteristics of leiomyomas of the gastrointestinal tract, and to investigate the distribution characteristics of interstitial cells of Cajal ( ICCs ) in gastrointestinal leiomyomas. Methods: One hundred and forty-seven cases of leiomyomas of gastrointestinal tract were collected at the Second Affiliated Hospital of Zhengzhou University from June 2012 to June 2017. Clinical and pathologic findings were analyzed, combined with immunohistochemistry, Alcian blue-osafranin staining and molecular study...
June 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29886072/study-of-the-allergenic-potential-of-bacillus-thuringiensis-cry1ac-toxin-following-intra-gastric-administration-in-a-murine-model-of-food-allergy
#17
Karla I Santos-Vigil, Damaris Ilhuicatzi-Alvarado, Ana L García-Hernández, Juan S Herrera-García, Leticia Moreno-Fierros
Cry1Ac toxin, from Bacillus thuringiensis, is widely used as a biopesticide and expressed in genetically modified (GM) plants used for human and animal consumption. Since Cry1Ac is also immunogenic and able to activate macrophages, it is crucial to thoroughly evaluate the immunological effects elicited after intra-gastric administration. The allergenic potential of purified Cry1Ac was assessed and compared with that induced in a murine model of food-allergy to ovalbumin (OVA), in which animals are sensitized with the adjuvant Cholera toxin (CT)...
June 7, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29885783/acute-lower-gastrointestinal-bleeding-in-sudanese-patients-a-study-on-301-patients-in-a-specialized-centre
#18
Nassir Alhaboob Arabi, Abdulmagid Mohammed Musaad, Fatima Abbas Habiballah Mohammed, Elsaggad Eltayeb Ahmed, Muataz Salah Eldin Abdelaziz
BACKGROUND AND STUDY AIMS: Lower gastrointestinal bleeding originates from a site distal to the ligament of Treitz. It can present as an acute life-threatening or chronicbleeding. It is common among older patients and those with comorbidity. The common causes are diverticular disease, angiodysplasias, neoplasms, colitis, ischaemia and anorectal disorders. The aim of this study is to determine the prevalence and causes of acute lower gastrointestinal bleeding among Sudanese patients. PATIENTS AND METHODS: In a period of 2 years we studied 301 patients with fresh rectal bleeding out of 5625 patients with gastrointestinal bleeding in Ibn Sina Specialized Hospital, Khartoum, Sudan, This is a cross sectional observational hospital based study...
June 6, 2018: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29882196/prone-positioning-on-a-belly-board-decreases-rectal-and-bowel-doses-in-pelvic-intensity-modulated-radiation-therapy-imrt-for-prostate-cancer
#19
Renáta Kószó, Linda Varga, Emese Fodor, Zsuzsanna Kahán, Adrienne Cserháti, Katalin Hideghéty, Zsófia Együd, Csilla Szabó, Emőke Borzási, Dorottya Szabó, Kitti Müllner, Zoltán Varga, Anikó Maráz
The presence of normal tissues in the irradiated volume limits dose escalation during pelvic radiotherapy (RT) for prostate cancer. Supine and prone positions on a belly board were compared by analyzing the exposure of organs at risk (OARs) using intensity modulated RT (IMRT). The prospective trial included 55 high risk, localized or locally advanced prostate cancer patients, receiving definitive image-guided RT. Computed tomography scanning for irradiation planning was carried out in both positions. Gross tumor volume, clinical and planning target volumes (PTV) and OARs were delineated, defining subprostatic and periprostatic rectal subsegments...
June 7, 2018: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29879761/the-protective-effect-of-melissa-officinalis-l-in-visceral-hypersensitivity-in-rat-using-2-models-of-acid-induced-colitis-and-stress-induced-irritable-bowel-syndrome-a-possible-role-of-nitric-oxide-pathway
#20
Fatemeh Dolatabadi, Amir H Abdolghaffari, Mohammad H Farzaei, Maryam Baeeri, Fatemeh S Ziarani, Majid Eslami, Mohammad Abdollahi, Roja Rahimi
Background/Aims: The aim of present study is to estimate the effects of Melissa officinalis L. (MO) on visceral hypersensitivity (VH), defecation pattern and biochemical factors in 2 experimental models of irritable bowel syndrome (IBS) and the possible role of nitric oxide. Methods: Two individual models of IBS were induced in male Wistar-albino rats. In the acetic acid model, the animals were exposed to rectal distension and abdominal withdrawal reflex, and the defecation patterns were determined...
June 4, 2018: Journal of Neurogastroenterology and Motility
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