keyword
https://read.qxmd.com/read/38535894/prognostic-impact-of-primary-tumour-location-after-curative-resection-in-stage-i-iii-colorectal-cancer-a-single-centre-retrospective-study
#1
JOURNAL ARTICLE
Manabu Inoue, Yukihide Kanemitsu, Shunsuke Tsukamoto, Konosuke Moritani, Yasuyuki Takamizawa, Hiroyuki Daiko
OBJECTIVE: The relationship of tumour site with post-recurrence course and outcome after primary surgery in resectable colorectal cancer is unclear. This study investigated the prognostic impact of primary tumour location following radical resection without preoperative treatment in Stage I-III colorectal cancer. METHODS: We analyzed 3770 patients with Stage I-III colorectal cancer who underwent curative resection at our hospital during 2000-15. We defined the right-sided colon as the cecum, ascending colon and transverse colon, and the left-sided colon as the descending colon, sigmoid and rectosigmoid junction...
March 26, 2024: Japanese Journal of Clinical Oncology
https://read.qxmd.com/read/38533503/unraveling-the-causal-role-of-immune-cells-in-gastrointestinal-tract-cancers-insights-from-a-mendelian-randomization-study
#2
JOURNAL ARTICLE
Yu-Xiang Wang, Chao-Ping Zhou, Da-Tian Wang, Jun Ma, Xue-Hu Sun, Yao Wang, Ya-Ming Zhang
BACKGROUND: Despite early attempts, the relationship between immune characteristics and gastrointestinal tract cancers remains incompletely elucidated. Hence, rigorous and further investigations in this domain hold significant clinical relevance for the development of novel potential immunotherapeutic targets. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis using the tools available in the "TwoSampleMR" R package. The GWAS data for these 731 immune traits were sourced from the GWAS Catalog database...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38532592/-application-value-of-laparoscopic-double-stapler-firings-and-double-stapling-technique-combined-with-rectal-eversion-and-total-extra-abdominal-resection-in-the-sphincter-preserving-resection-of-low-rectal-cancer
#3
JOURNAL ARTICLE
H Liang, K Q Wu, Q W Fan, W Zheng, H Zhang, J W Bai, J M Li, J Q Chen, C Zhang
Objectives: To investigate the application value of laparoscopic double stapler firings and double stapling technique combined with rectal eversion and total extra-abdominal resection (LDER) in the anal preservation treatment of low rectal cancer. Methods: Inclusion criteria: (1) age was 18-70; (2) the distance of the lower tumor edge from the anal verge was 4-5 cm; (3) primary tumor with a diameter ≤3 cm; (4) preoperative staging of T1~2N1~2M0; (5) "difficult pelvis", defined as ischial tuberosity diameter<10 cm or body mass index>25 kg/m2 ; (6) patients with strong intention for sphincter preservation; (7) no preoperative treatment (e...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532103/identification-of-unique-rectal-cancer-specific-subtypes
#4
JOURNAL ARTICLE
Batuhan Kisakol, Anna Matveeva, Manuela Salvucci, Alexander Kel, Elizabeth McDonough, Fiona Ginty, Daniel B Longley, Jochen H M Prehn
BACKGROUND: Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often have received neoadjuvant chemoradiotherapy which likely has a significant impact on gene expression. METHODS: We collected mRNA expression profiles for rectal and colon cancer samples (n = 2121). We observed that (i) Consensus Molecular Subtyping (CMS) had a different prognosis in treatment-naïve rectal vs...
March 26, 2024: British Journal of Cancer
https://read.qxmd.com/read/38531046/experience-with-laparoscopic-and-robotic-colon-surgery-together-with-other-major-minimally-invasive-procedures-for-unrelated-pathologies
#5
JOURNAL ARTICLE
Hugo J R Bonatti
Background: Indications for combined colon surgery together with other procedures include oncologic multivisceral resections and abdominal trauma. It is unclear if combining minimally invasive (MI) colon surgery with unrelated other procedures increases the risk for complications. Patients and Methods: The surgical database from two institutions during a 10-year period was queried for combined colon surgeries together with other interventions. All open cases, combined cases performed for one pathology and MI colectomies together with a minor procedure, were excluded...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38527938/safety-and-feasibility-of-colonoscopy-in-nonagenarians-a-systematic-review-meta-analysis-and-meta-regression-analysis
#6
REVIEW
Shahab Hajibandeh, Shahin Hajibandeh, Azel Regan, Jennifer Waterman, Christopher M B Stewart, James Ansell, James Horwood, Simon Phillips, Michael Davies
AIM: The aim of this work was to evaluate the safety and feasibility of performing colonoscopy in patients aged 90 years or over. METHOD: In compliance with PRISMA statement standards, a systematic review of studies reporting the outcomes of colonoscopy in patients aged ≥90 years was conducted. A proportional meta-analysis model was constructed to quantify the risk of outcomes and a direct comparison meta-analysis model was constructed to compare outcomes between nonagenarians and patients aged between 50 and 89 years via random-effects models...
March 25, 2024: Colorectal Disease
https://read.qxmd.com/read/38527929/perioperative-outcomes-of-ileorectal-anastomosis-an-analysis-of-823-patients
#7
JOURNAL ARTICLE
Adam Truong, Katherine Hu, David Liska, Michael Valente, Tracy Hull, Scott R Steele, Stefan D Holubar
AIM: Ileorectal anastomosis (IRA) following total abdominal colectomy (TAC) allows for resortation of bowel continuity but prior studies have reported rates of anastomotic leak (AL) to be as high as 23%. We aimed to report rates of AL and complications in a large cohort of patients undergoing IRA. We hypothesized that AL rates were lower than previously reported and that selective use of diverting loop ileostomy (DLI) is associated with decreased AL rates. METHOD: Patients undergoing TAC or end-ileostomy reversal with IRA, with or without DLI, between 1980 and 2021 were identified from a prospectively maintained institutional database and retrospectively analysed...
March 25, 2024: Colorectal Disease
https://read.qxmd.com/read/38525960/unveiling-the-hidden-consequences-the-initial-impact-of-covid-19-on-colorectal-cancer-operation
#8
JOURNAL ARTICLE
Davide Ferrari, Tommaso Violante, Courtney N Day, Nicholas P McKenna, Kellie L Mathis, Eric J Dozois, David W Larson
BACKGROUND: The COVID-19 pandemic has severely affected healthcare systems globally, resulting in significant delays and challenges in various medical treatments, particularly in cancer care. This study aims to investigate the repercussions of the pandemic on surgical interventions for colorectal cancer in the United States, using data from the National Cancer Database (NCDB). METHODS: We conducted a retrospective analysis of the NCDB, encompassing adult patients who underwent surgical procedures for colon and rectal cancer in 2019 (pre-COVID) and 2020 (COVID)...
March 25, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38525799/how-have-us-colorectal-cancer-mortality-trends-changed-in-the-past-20%C3%A2-years
#9
JOURNAL ARTICLE
Jia Yi Tan, Yong-Hao Yeo, Wern Lynn Ng, Zhi Ven Fong, Justin T Brady
In the last two decades, colorectal cancer (CRC) mortality has been decreasing in the United States. However, the mortality trends for the different subtypes of CRC, including different sides of colon, rectosigmoid, and rectal cancer remain unclear. We analyzed the mortality trends of different subtypes of CRC based on Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research data from 1999 to 2020. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and examined the trends over time by estimating the average annual percent change (AAPC) using the Joinpoint Regression Program...
March 25, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38524669/gut-microbiome-dynamics-and-enterobacterales-infection-in-liver-transplant-recipients-a-prospective-observational-study
#10
JOURNAL ARTICLE
Federica D'Amico, Matteo Rinaldi, Renato Pascale, Marco Fabbrini, Maria Cristina Morelli, Antonio Siniscalchi, Cristiana Laici, Simona Coladonato, Matteo Ravaioli, Matteo Cescon, Simone Ambretti, Pierluigi Viale, Patrizia Brigidi, Silvia Turroni, Maddalena Giannella
BACKGROUND & AIMS: The aim of this study was to investigate gut microbiome (GM) dynamics in relation to carbapenem-resistant Enterobacterales (CRE) colonization, CRE infection, and non-CRE infection development within 2 months after liver transplant (LT). METHODS: A single-center, prospective study was performed in patients undergoing LT from November 2018 to January 2020. The GM was profiled through 16S rRNA amplicon sequencing of a rectal swab taken on the day of transplantation, and fecal samples were collected weekly until 1 month after LT...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38523824/management-of-an-undetectable-diverticular-bleed-a-case-report-and-literature-review
#11
Zubir S Rentiya, Lokeshwar Raaju Addi Palle, Sanni Emmanuel, Heeya Shah, Abiodun Adegbite, Carlo Kristian Chu Carredo, Ronald Mauricio Blanco Montecino, Ummul Z Asfeen, Akbar Hussain, Ogbonnaya Akuma, Aadil Mahmood Khan, Anasonye Emmanuel Kelechi
Diverticular bleeding is the most common cause of lower gastrointestinal bleeding and accounts for 20.8%-41.6% of cases in the Western world. Management involves initial resuscitation followed by diagnostic assessment. Colonoscopy is the investigation of choice as it localizes the bleed and has the potential to effectively deliver therapeutic interventions. Other diagnostic modalities include flexible sigmoidoscopy, a tagged red blood cell scan, or angiography. In cases where the bleeding source cannot be identified, intraoperative enteroscopy has emerged as a valuable tool for investigating obscure gastroenterology bleeds in specific patients...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38523291/introduction-of-extraperitoneal-tunneling-method-a-way-to-secure-the-drain-tube-in-the-pelvic-cavity-after-proctectomy
#12
JOURNAL ARTICLE
Sung Il Kang, Sohyun Kim, Jae Hwang Kim
The effectiveness of closed drainage tube insertion after low anterior resection has been controversial. We believe that drain tube displacement, which occurs up to 35% in real clinical practice, reduces the effectiveness of the drain tube. We report in this video a simple way to secure the drain tube in the pelvic cavity after low anterior resection and introduce a case that used the drain fixation method and treated anastomotic leakage without interventional procedure.
March 25, 2024: Annals of Coloproctology
https://read.qxmd.com/read/38523290/estimation-of-risk-posed-by-malignant-polyps-amongst-colorectal-surgeons-in-australia-and-new-zealand
#13
JOURNAL ARTICLE
Andrew P Zammit, Ian Brown, John D Hooper, David A Clark, Andrew D Riddell
PURPOSE: The estimation of the risk posed by malignant polyps for residual or lymphatic disease plays a central role. This study investigated colorectal surgeons' assessment of these risks associated with malignant polyps. METHODS: A cross-sectional questionnaire was electronically administered to colorectal surgeons in Australia and New Zealand in October 2022. The questionnaire contained 17 questions on demographics, when surgeons consider colorectal resection appropriate, and the risk assessment for 5 hypothetical malignant polyps...
March 25, 2024: Annals of Coloproctology
https://read.qxmd.com/read/38519855/multidisciplinary-teams-and-social-science-a-patient-perspective
#14
JOURNAL ARTICLE
Cheri Ostroff
Multidisciplinary teams (MDTs) are common in colorectal cancer and have been deemed important when providing care. Yet they take place outside of the patient, often with little consideration of the patient's views, goals and desires. In this paper specific examples from a patient perspective are integrated with the social science literature to provide an overview of areas of disconnect between MDT recommendations and the individual patient. The reasons for these disconnects are explored, including how MDTs relate to dyadic patient-clinician relationships, weak incorporation of patient-oriented outcomes in MDTs, poor integration of nonmedical patient information and the patient perspective and the impact of team dynamics and cognitive decision biases...
March 22, 2024: Colorectal Disease
https://read.qxmd.com/read/38519847/intrarectal-formalin-treatment-for-haemorrhagic-radiation-induced-proctopathy-efficacy-and-safety
#15
JOURNAL ARTICLE
Darina Kohoutova, Ana Wilson, Caroline Gee, Ramy Elhusseiny, Linda Wanders, David Cunningham
AIM: Pelvic radiotherapy is limited by dose-dependent toxicity to surrounding organs. The aim of this prospective study was to evaluate the efficacy and safety of intrarectal formalin treatment for radiotherapy-induced haemorrhagic proctopathy (RHP) at the Royal Marsden Hospital. METHOD: Adult patients were enrolled. Haemoglobin was evaluated before and after formalin treatment. Antiplatelet and/or anticoagulation treatment and administration of transfusion were recorded...
March 22, 2024: Colorectal Disease
https://read.qxmd.com/read/38518387/metformin-s-role-in-lowering-colorectal-cancer-risk-among-individuals-with-diabetes-from-the-southern-community-cohort-study
#16
JOURNAL ARTICLE
Thomas Lawler, Zoe L Walts, Lauren Giurini, Mark Steinwandel, Loren Lipworth, Harvey J Murff, Wei Zheng, Shaneda Warren Andersen
BACKGROUND: Metformin, utilized to manage hyperglycemia, has been linked to a reduced risk of colorectal cancer (CRC) among individuals with diabetes. However, evidence is lacking for non-Hispanic Black individuals and those with lower socioeconomic status (SES), who face elevated risk for both diabetes and CRC. In this study, we investigated the association between metformin use and incident CRC risk within the Southern Community Cohort Study (SCCS), a racially- and SES-diverse prospective cohort...
March 21, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38517591/abdominal-massage-to-prevent-ileus-after-colorectal-surgery-a-single-center-prospective-randomized-clinical-trial-the-matrac-trial
#17
REVIEW
Jean-Luc Faucheron, Damien Vincent, Mihaela Barbut, Isabelle Jacquet-Perrin, Pierre-Yves Sage, Alison Foote, Alexandre Bellier, Jean-Louis Quesada, Fatah Tidadini, Bertrand Trilling
BACKGROUND: There is scarce literature on the effect of mechanical abdominal massage on the duration of ileus after colectomy, particularly in the era of enhanced recovery after surgery (ERAS). The aim of this study was to determine whether abdominal massage after colorectal surgery with anastomosis and no stoma helps toward a faster return of intestinal transit. METHODS: This study was a superiority trial and designed as a prospective open-label, single-center, randomized controlled clinical trial with two parallel groups...
March 22, 2024: Techniques in Coloproctology
https://read.qxmd.com/read/38517090/using-computed-tomgraphy-based-pelvimetry-and-visceral-obesity-measurements-to-predict-total-mesorectal-excision-quality-for-patients-undergoing-rectal-cancer-surgery
#18
JOURNAL ARTICLE
Vladimir Bolshinsky, David Sweet, Dominic Vitello, Xue Jia, Stefan Holubar, James Church, Brian R Herts, Scott R Steele
BACKGROUND: A complete total mesorectal excision is the gold standard in curative rectal cancer surgery. Ensuring quality is challenging in a narrow pelvis, and obesity amplifies technical difficulties. Pelvimetry is the measurement of pelvic dimensions, but its role in gauging preoperatively difficulty of proctectomy is largely unexplored. OBJECTIVE: To determine pelvic structural factors associated with incomplete total mesorectal excision following curative proctectomy and build a predictive model for total mesorectal excision quality...
March 22, 2024: Diseases of the Colon and Rectum
https://read.qxmd.com/read/38515957/colon-and-rectal-cancer-an-emergent-public-health-problem
#19
REVIEW
Marina Pinheiro, David Nascimento Moreira, Michele Ghidini
Colorectal cancer ranks third globally, with a high mortality rate. In the United States, and different countries in Europe, organized population screenings exist and include people between 50 and 74 years of age. These screenings have allowed an early diagnosis and consequently an improvement in health indicators. Colon and rectal cancer (CRC) is a disease of particular interest due to the high global burden associated with it and the role attributed to prevention and early diagnosis in reducing morbidity and mortality...
February 21, 2024: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/38514446/the-monkey-chased-the-weasel-is-it-irritable-bowel-syndrome-or-faecal-incontinence-we-find-following-obstetric-anal-sphincter-injuries
#20
JOURNAL ARTICLE
Christopher J Young
No abstract text is available yet for this article.
March 21, 2024: Colorectal Disease
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