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Nobumasa Ohara, Yasuyuki Uemura, Naomi Mezaki, Keita Kimura, Masanori Kaneko, Hirohiko Kuwano, Katsuya Ebe, Toshio Fujita, Takeshi Komeyama, Hiroyuki Usuda, Yuto Yamazaki, Takashi Maekawa, Hironobu Sasano, Kenzo Kaneko, Kyuzi Kamoi
BACKGROUND: Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors. Hypertension secondary to pheochromocytoma is often paroxysmal, and patients occasionally present with sudden attacks of alternating hypertension and hypotension. Spontaneous, extensive necrosis within the tumor that is associated with catecholamine crisis is an infrequent complication of adrenal pheochromocytoma, but its pathogenesis remains unclear. CASE PRESENTATION: A 69-year-old Japanese man developed acute-onset episodic headaches, palpitations, and chest pains...
October 12, 2016: Journal of Medical Case Reports
Victor Srougi, Jose L Chambo, Fabio Y Tanno, Iracy S Soares, Madson Q Almeida, Maria A A Pereira, Miguel Srougi, Maria C Fragoso
PURPOSE: To evaluate the presentation and early surgical outcomes of elderly patients undergoing adrenalectomy for phaeochromocytoma. PATIENTS AND METHODS: A retrospective search was performed of our adrenal disorders database for patients who underwent surgery for phaeochromocytoma or paraganglioma between 2009 and 2014. Patients >60 years old were classified as elderly. The clinical manifestations, intraoperative course, and early postoperative outcomes of elderly patients were compared to those of younger individuals (<60 years old)...
July 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Amr El Kouny, Mohammed Al Harbi, Rashid Muhammad Arif, Nazar Ilyas, El Abbasy Omar Hamed, Maqsood Memon, Ali Nawaz, Vassilios Dimitriou
A 52 yearold female presented with a thoracic paravertebral tumour causing spinal nerve root compression and lower limbs neurologic symptoms. The patient was scheduled to undergo thoracic decompression laminectomy and instrumentation. Markedly severe hemodynamic fluctuations happened during the manipulation of the tumor and continued after the tumor was removed. After multimodal antihypertensive therapy the vital signs were adequately managed and the surgery was successfully performed without complications...
February 2016: Middle East Journal of Anesthesiology
Eugenia Yiannakopoulou
Nowadays robotic assisted adrenalectomy has become an alternative to conventional laparoscopic adrenalectomy. However, evidence on the possible advantages and drawbacks of robotic assisted adrenalectomy remains still limited. This manuscript aimed to review evidence on robotic assisted adrenalectomy in terms of surgical technique, feasibility, indications, oncological outcome and safety. Existing evidence, although limited, suggests that robotic assisted adrenalectomy is feasible and safe. However, the number of patients submitted to robotic assisted adrenalectomy is limited with the majority of them being operated for benign disease...
April 2016: International Journal of Surgery
Fabio Cesar Miranda Torricelli, Giovanni Scala Marchini, Jose Roberto Colombo, Rafael Ferreira Coelho, Willian Carlos Nahas, Miguel Srougi
A 25-year-old hypertensive female patient was referred to our institution. Initial workup exams demonstrated a 2.8 cm cortical lower pole tumor in the right kidney. She underwent laparoscopic partial nephrectomy without complications. Histopathologic examination revealed a rare juxtaglomerular cell tumor known as reninoma. After surgery, she recovered uneventfully and all medications were withdrawn. Case hypothesis: Secondary arterial hypertension is a matter of great interest to urologists and nephrologists...
January 2015: International Braz J Urol: Official Journal of the Brazilian Society of Urology
V Ambrosini, J J Morigi, C Nanni, P Castellucci, S Fanti
Neuroendocrine neoplasms (NEN) functional imaging is an evolving field that witnessed major advances in the past two decades. The routine use of PET/CT with an array of new radiotracers to specifically study NEN resulted in an increase in lesions detection. Currently, PET radiopharmaceuticals for NEN imaging include both metabolic ([18F]DOPA, [18F]FDG, [11C]/[18F]-HTP) and receptor-mediated compounds ([68Ga]DOTA-peptides). Discussion is still on-going regarding the clinical setting that may benefit the most from the use of one tracer over the other...
March 2015: Quarterly Journal of Nuclear Medicine and Molecular Imaging
C Spinelli, L Rossi, A Barbetta, C Ugolini, S Strambi
BACKGROUND AND AIMS: Ganglioneuromas are benign tumors which originate from the neural crest. This tumor affects mainly young patients rather than adult ones, and its most frequent localizations are mediastinum, retroperitoneum, adrenal glands and cervical region. Usually, ganglioneuromas are discovered as incidentalomas since they are often asymptomatic, even if they could present sympathetic or mass-related symptoms. To obtain a definitive diagnosis, histological exam is necessary since CT scan and MRI are not capable of distinguishing ganglioneuromas from other tumors, such as neuroblastomas or pheocromocytomas...
May 2015: Journal of Endocrinological Investigation
Giovanni Dapri, Viola Zulian, Maria Bortes, Guy-Bernard Cadière
No abstract text is available yet for this article.
March 2015: Surgical Oncology
S Hausen, A Treusch, C Hermes, P Boekstegers
This article presents the case of a patient with sudden onset of heart failure caused by transient severe left ventricular dysfunction with the typical pattern of stress-induced cardiomyopathy (takotsubo cardiomyopathy) who had wasp sting a few hours before admission in the presence of a previously asymptomatic pheochromocytoma. There seems to be correlation between the wasp-venom-induced pheochomocytoma crisis and acute onset of heart failure. Once pheocromocytoma is diagnosed, medical therapy is preferable before surgical treatment...
November 2014: Medizinische Klinik, Intensivmedizin und Notfallmedizin
Giovanni Cochetti, Francesco Barillaro, Andrea Boni, Michele Del Zingaro, Mearini Ettore
The Paraganglioma is the most common extra-adrenal pheochromocytoma arising from neural crest (1) (It will better to write: The paraganglioma is an extra-adrenal pheocromocytoma arising from the neural crest. 10% of pheocromocytomas are extra-adrenal and can arise form chromaffin tissue derived from primitive neuroectoderm). Minimally invasive techniques allow surgeons to perform the procedure without wide exposure and mobilization of intra abdominal organs. To our knowledge we present the third case of robotic excision of a retroperitoneal paraganglioma...
March 2014: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Rahul Gawri, Derek H Rosenzweig, Emerson Krock, Jean A Ouellet, Laura S Stone, Thomas M Quinn, Lisbet Haglund
INTRODUCTION: Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pain. However, little is known about how mechanical strain induces these changes. This study investigated the cellular and molecular changes as well as which inflammatory receptors and cytokines were upregulated in human intervertebral disc cells exposed to high mechanical strain (HMS) at low frequency...
2014: Arthritis Research & Therapy
Massimo Milione, Sara Pusceddu, Patrizia Gasparini, Flavia Melotti, Patrick Maisonneuve, Vincenzo Mazzaferro, Filippo G de Braud, Giuseppe Pelosi
Immunohistochemical loss of the succinate dehydrogenase subunit B (SDHB) has recently been reported as a surrogate biomarker of malignancy in sporadic and familial pheocromocytomas and paragangliomas through the activation of hypoxia pathways. However, data on the prevalence and the clinical implications of SDHB immunoreactivity in ileal neuroendocrine tumors are still lacking. Thirty-one consecutive, advanced primary midgut neuroendocrine tumors and related lymph node or liver metastases from 24 males and seven females were immunohistochemically assessed for SDHB...
2012: Cancers
Christina Matadial, Jadelis Giquel, Ricardo Martinez-Ruiz
Perioperative management of a patient with ischemic heart disease with coexisting abdominal aortic aneurysm and pheochromocytoma creates a difficult management dilemma, and surgical intervention in these patients carries a significant risk. The state of catecholamine excess and various other coexisting factors can lead to simultaneous occurrence of abdominal aortic aneurysm and pheocromocytoma. The purpose of this report is to present an integrated approach to the management of concomitant abdominal aortic aneurysm and pheochromocytoma, where a combined surgical approach in addressing these two lesions was preferable due to patient comorbidities and surgical implications without significant complication...
2013: JRSM Cardiovascular Disease
Daniella L Shmuel, Yonaira Cortes
OBJECTIVE: To review and summarize current information regarding the pathophysiology and clinical manifestations associated with anaphylaxis in dogs and cats. The etiology, diagnosis, treatment, and prognosis is discussed. ETIOLOGY: Anaphylaxis is a systemic, type I hypersensitivity reaction that often has fatal consequences. Many of the principal clinical manifestations involve organs where mast cell concentrations are highest: the skin, the lungs, and the gastrointestinal tract...
July 2013: Journal of Veterinary Emergency and Critical Care
Lorena Medina-Pulido, Míriam Molina-Arcas, Carles Justicia, Eduardo Soriano, Ferran Burgaya, Anna M Planas, Marçal Pastor-Anglada
Under several adverse conditions, such as hypoxia or ischaemia, extracellular levels of adenosine are elevated because of increased energy demands and ATP metabolism. Because extracellular adenosine affects metabolism through G-protein-coupled receptors, its regulation is of high adaptive importance. CNT2 (concentrative nucleoside transporter 2) may play physiological roles beyond nucleoside salvage in brain as it does in other tissues. Even though nucleoside transport in brain has mostly been seen as being of equilibrative-type, in the present study, we prove that the rat phaeochromocytoma cell line PC12 shows a concentrative adenosine transport of CNT2-type when cells are differentiated to a neuronal phenotype by treatment with NGF (nerve growth factor)...
September 15, 2013: Biochemical Journal
Toshiki Ito, Yutaka Kurita, Hitoshi Shinbo, Yasuhiro Yasumi, Tomomi Ushiyama
A 59-year-old woman who identified as a Jehovah's Witness was diagnosed with pheochromocytoma in the left adrenal gland, measuring 11 cm in diameter, during treatment for hypertension. Given her desire to undergo transfusion-less surgery for religious reasons, we obtained fully informed consent and had the patient sign both a transfusion refusal and exemption-from-responsibility certificate and received consent to instead use plasma derivatives, preoperative diluted autologous transfusion and intraoperative salvaged autologous transfusion...
May 2013: Nihon Hinyōkika Gakkai Zasshi. the Japanese Journal of Urology
Daisuke Konno, Ryo Nishino, Yutaka Ejima, Eiko Ohnishi, Kuniko Sato, Shin Kurosawa
BACKGROUND: Intensive perioperative management is required for adrenalectomy in patients with pheocromocytoma because of the unstable hemodynamics and life threatening cardiovascular disturbances due to catecholamine surge from the neuroendocrine tumors. The aim of this study was to assess the perioperative factors contributing to the hemodynamic changes during surgery in pheochromocytoma. METHODS: Ten patients with pheochromocytoma undergoing elective adrenalectomy were enrolled in this retrospective study...
April 2013: Masui. the Japanese Journal of Anesthesiology
J C Trullàs
No abstract text is available yet for this article.
December 2012: Revista Clínica Española
J Rojo Alvaro, M Toni, Md Ollero, Jj Pineda, P Munárriz, E Anda
BACKGROUND: The pheochromocytoma is a catecholamine secreting tumour derived from chromaffin cells of the sympathetic nervous system. Eighty to eighty-five percent of these tumours are localized in the adrenal medulla. When pheocromocytomas are found outside the adrenal gland they are referred to as extra-adrenal pheochromocytomas or paragangliomas. The diagnosis is confirmed by elevation of catecholamines and the metanephrines in blood plasma and urine. Localization of the tumour should be done following biochemical diagnosis by means of CT scan and/or MRI...
May 2012: Anales del Sistema Sanitario de Navarra
Katarzyna Dudziak, Ingo Rettig, Patrick Adam, Marius Horger, Hartmut P Neumann, Karsten Müssig
HISTORY AND ADMISSION FINDINGS: A 48-year-old patient presented with an insufficient control of his diabetes mellitus which was known since 3 years. The antidiabetic medication comprised metformin and exenatide. INVESTIGATIONS: Physical examination revealed, beside elevated blood pressure, abdominal purple striae. Endocrine testing was consistent with ectopic Cushing's syndrome. Abdominal CT showed a 5 cm measuring, inhomogeneous, contrast-enhanced mass in the right suprarenal area which was positive on iodine-131 MIBG SPECT...
October 2011: Deutsche Medizinische Wochenschrift
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