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Zika and microcephaly

Luis Del Carpio-Orantes, María del Carmen González-Clemente
In this paper the relationship between the incidence of microcephaly and various arboviruses in current boom is exposed. It stands out that in the infection by the dengue virus, there have been no cases of microcephaly, however in the case series of chikungunya infection, incidence of cases with this affectation was reported, highlighting a cohort called CHIMERE; also the highest incidence of microcephaly associated with the mentioned Zika virus, which has been widely studied. All this, due to the neurotropism of these arboviruses...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
Michelle M Haby, Mariona Pinart, Vanessa Elias, Ludovic Reveiz
Objective: To conduct a systematic review to estimate the prevalence of asymptomatic Zika virus infection in the general population and in specific population groups. Methods: We searched PubMed®, Embase® and LILACS online databases from inception to 26 January 2018. We included observational epidemiological studies where laboratory testing was used to confirm positive exposure of participants to Zika virus and in which Zika virus symptom status was also recorded...
June 1, 2018: Bulletin of the World Health Organization
Lianpan Dai, Qihui Wang, Hao Song, George Fu Gao
Zika virus (ZIKV) is a re-emerged human pathogen, belonging to a super serogroup with dengue virus. Infection of ZIKV can lead to severe congenital symptoms, such as microcephaly, in newborns and Guillain-Barré syndrome in adults. To date, no prophylactics and therapeutics are available. Flavivirus envelope (E) protein represents the major target for neutralizing antibodies, while antibody response is the key correlate of protection against ZIKV infection. A panel of monoclonal antibodies (MAbs) were found to neutralize ZIKV infection and some of them exhibited strong potential as antivirals...
2018: Sub-cellular Biochemistry
Pendru Raghunath
No abstract text is available yet for this article.
April 2018: Iranian Journal of Public Health
Alfonso J Rodriguez-Morales, Jaime A Cardona-Ospina, Valeria Ramirez-Jaramillo, Javier A Gaviria, Gloria María González-Moreno, Juan D Castrillón-Spitia, Alejandra López-Villegas, Estefania Morales-Jiménez, Valentina Ramírez-Zapata, German Eduardo Rueda-Merchán, Adriana M Trujillo, Fredy A Tabares-Villa, Valentina Henao-SanMartin, David R Murillo-Garcia, Johana Andrea Herrera-Soto, Marta Liliana Buitrago-Cañas, Matthew H Collins, Juan Carlos Sepúlveda-Arias, José J Londoño, Héctor D Bedoya-Rendón, Javier de Jesús Cárdenas-Pérez, Sandra X Olaya, Guillermo J Lagos-Grisales
BACKGROUND: Zika virus (ZIKV) infection has emerged as a significant threat for pregnant women and newborns in populations living in or visiting Latin America. We previously reported a preliminary analysis in Sucre, Colombia, as the first group of pregnant women with RT-PCR-confirmed ZIKV (ZIKa enEmbarazadas yReciénNacidos enCOLombia, ZIKERNCOL). METHODS: In this second report, findings of the first 86 pregnant women from La Virginia and Dosquebradas (municipalities), Risaralda, Colombia, with RT-PCR-confirmed ZIKV infection are reported...
June 9, 2018: Travel Medicine and Infectious Disease
Jade Gieseke Guevara, Swati Agarwal-Sinha
BACKGROUND: As the number of children with Zika virus-related complications grows, the long-term developmental trajectory and its effects on families are unknown. We present the first known case of congenital Zika syndrome seen at our institution with significant fundus findings. CASE PRESENTATION: A 3-day-old Hispanic baby girl presented with severe microcephaly of 24 cm and temperature instability at birth. Her mother had traveled to Honduras early in pregnancy and testing of amniotic fluid was positive for Zika virus via polymerase chain reaction...
June 9, 2018: Journal of Medical Case Reports
Juan Eugenio Hernández-Ávila, Lina Sofía Palacio-Mejía, Hugo López-Gatell, Celia M Alpuche-Aranda, Diana Molina-Vélez, Leonel González-González, Mauricio Hernández-Ávila
Objective: To assess the magnitude of the Mexican epidemic of Zika virus infection and the associated risk of microcephaly. Methods: From the reported number of laboratory-confirmed symptomatic infections among pregnant women and the relevant birth rate, we estimated the number of symptomatic cases of infection that occurred in Mexico between 25 November 2015, when the first confirmed Mexican case was reported, and 20 August 2016. We used data from the birth certificates to compare mean monthly incidences of congenital microcephaly before (1 January 2010-30 November 2015) and after (1 December 2015-30 September 2017) the introduction of Zika virus, stratifying the data according to whether the mother's place of residence was at an altitude of at least 2200 m above sea level...
May 1, 2018: Bulletin of the World Health Organization
Sunam Gurung, Alisha N Preno, Jamie P Dubaut, Hugh Nadeau, Kimberly Hyatt, Nicole Reuter, Bharti Nehete, Roman F Wolf, Pramod Nehete, Dirk P Dittmer, Dean A Myers, James F Papin
Zika virus (ZIKV) is an emerging mosquito-borne flavivirus with devastating outcomes seen recently in the Americas due to the association of maternal ZIKV infection with fetal microcephaly and other fetal malformations not previously associated with flavivirus infections. Here, we have developed the olive baboon ( Papio anubis ) as a non-human primate (NHP) translational model for the study of ZIKV pathogenesis and associated disease outcomes to contrast and compare with humans and other major NHPs such as macaques...
June 6, 2018: Journal of Virology
Isis Nem de Oliveira Souza, Paula S Frost, Julia V França, Jéssica B Nascimento-Viana, Rômulo L S Neris, Leandro Freitas, Daniel J L L Pinheiro, Clara O Nogueira, Gilda Neves, Leila Chimelli, Fernanda G De Felice, Ésper A Cavalheiro, Sergio T Ferreira, Iranaia Assunção-Miranda, Claudia P Figueiredo, Andrea T Da Poian, Julia R Clarke
Although congenital Zika virus (ZIKV) exposure has been associated with microcephaly and other neurodevelopmental disorders, long-term consequences of perinatal infection are largely unknown. We evaluated short- and long-term neuropathological and behavioral consequences of neonatal ZIKV infection in mice. ZIKV showed brain tropism, causing postnatal-onset microcephaly and several behavioral deficits in adulthood. During the acute phase of infection, mice developed frequent seizures, which were reduced by tumor necrosis factor-α (TNF-α) inhibition...
June 6, 2018: Science Translational Medicine
Kristen Heitzinger, Douglas A Thoroughman, Kimberly A Porter
Because infection with Zika virus during pregnancy can cause microcephaly and other birth defects, women of childbearing age are an important population for targeting of Zika-related public health messaging. To improve Zika-related communication and outreach in Kentucky, we conducted a survey to assess Zika knowledge, attitudes, and practices among all women of childbearing age who received a negative Zika test result from the state public health laboratory during February to July 2016. Although >90% of the 55 respondents knew the virus could be transmitted by mosquitoes and caused birth defects, just 56% (31/55) knew the virus could be sexually transmitted...
June 2018: Preventive Medicine Reports
Taíssa Ferreira Cardoso, Rosana Silva Dos Santos, Raquel Miranda Corrêa, Juliana Vieira Campos, Ricardo de Bastos Silva, Christine Castinheiras Tobias, Arnaldo Prata-Barbosa, Antonio José Ledo Alves da Cunha, Halina Cidrini Ferreira
No abstract text is available yet for this article.
June 1, 2018: Archives of Disease in Childhood
Yi Shi, Lianpan Dai, Hao Song, George F Gao
Zika virus (ZIKV), first discovered in the Zika forest in Uganda in 1947 was understudied until the recent explosive epidemic in several South American countries where it has become strongly associated with congenital birth defects leading to severe cranial malformations and neurological conditions. The increase in number of case of microcephaly in newborn children associated with ZIKV infection triggered the World Health Organization to declare the epidemic as a Public Health Emergency of International Concern in February of 2016...
2018: Advances in Experimental Medicine and Biology
Haryelle Náryma Confessor Ferreira, Veronica Schiariti, Isabelly Cristina Rodrigues Regalado, Klayton Galante Sousa, Silvana Alves Pereira, Carla Patrícia Novaes Dos Santos Fechine, Egmar Longo
INTRODUCTION: The increase in the number of cases of microcephaly in Brazil and its association with the Zika virus (ZIKV) is a global public health problem. The International Classification of Functioning Disability and Health (ICF) model is a powerful tool and extremely relevant in managing disability. OBJECTIVE: Describe the functioning profile of children with microcephaly associated with ZIKV in two states of northeastern Brazil. METHODS: This is a descriptive cross-sectional study...
May 29, 2018: International Journal of Environmental Research and Public Health
Marcia C Castro, Qiuyi C Han, Lucas R Carvalho, Cesar G Victora, Giovanny V A França
An increase in microcephaly, associated with an epidemic of Zika virus (ZIKV) in Brazil, prompted the World Health Organization to declare a Public Health Emergency of International Concern in February 2016. While knowledge on biological and epidemiological aspects of ZIKV has advanced, demographic impacts remain poorly understood. This study uses time-series analysis to assess the impact of ZIKV on births. Data on births, fetal deaths, and hospitalizations due to abortion complications for Brazilian states, from 2010 to 2016, were used...
May 29, 2018: Proceedings of the National Academy of Sciences of the United States of America
Julien Thézé, Tony Li, Louis du Plessis, Jerome Bouquet, Moritz U G Kraemer, Sneha Somasekar, Guixia Yu, Mariateresa de Cesare, Angel Balmaseda, Guillermina Kuan, Eva Harris, Chieh-Hsi Wu, M Azim Ansari, Rory Bowden, Nuno R Faria, Shigeo Yagi, Sharon Messenger, Trevor Brooks, Mars Stone, Evan M Bloch, Michael Busch, José E Muñoz-Medina, Cesar R González-Bonilla, Steven Wolinsky, Susana López, Carlos F Arias, David Bonsall, Charles Y Chiu, Oliver G Pybus
The Zika virus (ZIKV) epidemic in the Americas established ZIKV as a major public health threat and uncovered its association with severe diseases, including microcephaly. However, genetic epidemiology in some at-risk regions, particularly Central America and Mexico, remains limited. We report 61 ZIKV genomes from this region, generated using metagenomic sequencing with ZIKV-specific enrichment, and combine phylogenetic, epidemiological, and environmental data to reconstruct ZIKV transmission. These analyses revealed multiple independent ZIKV introductions to Central America and Mexico...
May 15, 2018: Cell Host & Microbe
Leonelo E Bautista, Víctor M Herrera
BACKGROUND: We evaluated whether outbreaks of Zika virus (ZIKV) infection, newborn microcephaly, and Guillain-Barré syndrome (GBS) in Latin America may be detected through current surveillance systems, and how cases detected through surveillance may increase health care burden. METHODS: We estimated the sensitivity and specificity of surveillance case definitions using published data. We assumed a 10% ZIKV infection risk during a non-outbreak period and hypothetical increases in risk during an outbreak period...
May 24, 2018: BMC Public Health
Anneliese Depoux, Aline Philibert, Serge Rabier, Henri-Jean Philippe, Arnaud Fontanet, Antoine Flahault
While until recently the small and isolated Zika outbreaks in Eastern Asia and Pacific islands had been overlooked, the large-scale outbreak that started in Brazil in 2015 and the increase of microcephaly cases in the same place and time made media headlines. Considered as harmless until recently, Zika has given rise to an important global crisis that poses not only health challenges but also environmental, economical, social, and ethical challenges for states and people around the world. The main objective of this paper is to review the recent Zika outbreak by covering a broad range of disciplines and their interactions...
2018: Public Health Reviews
Jeanine P D Guidry, Kellie E Carlyle, Jessica G LaRose, Paul Perrin, Mark Ryan, Marcus Messner, Jay Adams
Introduction: The Zika virus is associated with the birth defect microcephaly, and while a vaccine was not available in early- 2017, several were under development. This study's purpose was to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Design and methods: In order to study the effects of Zika message framing (gain vs . loss) and visual type (photo vs . infographic) on future Zika vaccine uptake intent, a 2×2 between-subjects experiment was performed via an online survey in 2017 among 339 U...
February 5, 2018: Journal of Public Health Research
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
L C Hygino da Cruz, O J M Nascimento, F P P L Lopes, I R F da Silva
When the first suspected cases of neurologic disorders associated with the Zika virus were noticed in Brazil in late 2015, several studies had been conducted to understand the pathophysiology of the disease and its associated complications. In addition to its well-established association with microcephaly in neonates, the Zika virus infection has also been suggested to trigger other severe neurologic complications in adults, such as Guillain-Barré syndrome, radiculomyelitis, and meningoencephalitis. Hence, the Zika virus should be deemed a global threat that can cause devastating neurologic complications among individuals in all age ranges...
May 17, 2018: AJNR. American Journal of Neuroradiology
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