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https://www.readbyqxmd.com/read/30218751/man1b1-is-associated-with-poor-prognosis-and-modulates-proliferation-and-apoptosis-in-bladder-cancer
#1
Hai-Feng Wang, Jian-Hui Wu, Jun-Wei Gai, Shi-Qiang Yang, Qing-Tong Ma, Hong-Shun Ma, Qiang Feng
Bladder cancer (BC) has been regarded as the most common malignancy of the urinary system worldwide. With lack of investigations for molecular pathogenesis underlying that develop BC, the therapeutic efficacy of several therapeutic approaches existing is still unsatisfactory. Here, our study aimed to explore the potentially biological function of MAN1B1 on BC. In this study, MAN1B1 expression level in BC tissues and normal tissues was analyzed based on The Cancer Genome Atlas (TCGA) data and correlation between its expression and prognosis was determined using Kaplan-Meier analysis...
September 12, 2018: Gene
https://www.readbyqxmd.com/read/30168126/the-cancer-genome-atlas-project-in-bladder-cancer
#2
Alejo Rodriguez-Vida, Seth P Lerner, Joaquim Bellmunt
Bladder cancer (BC) remains an aggressive disease with a poor prognosis, especially for patients with metastatic disease who have a limited median overall survival of 14 months. Urothelial carcinomas harbor frequent molecular dysregulations including recurrent mutations and copy number alteration, some of which could be potential therapeutic targets. However, no molecularly targeted agents have been approved to date for the treatment of advanced BC. Gaining new insights into the molecular landscape of BC will be critical to tailor future targeted agents for the treatment of advanced disease...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/30150714/a-catalogue-of-somatic-nrf2-gain-of-function-mutations-in-cancer
#3
Michael John Kerins, Aikseng Ooi
Identification and characterization of somatic mutations in cancer have important prognostication and treatment implications. Genes encoding the Nuclear factor (erythroid-derived 2)-like 2 (NRF2) transcription factor and its negative regulator, Kelch-like ECH-associated protein 1 (KEAP1), are frequently mutated in cancer. These mutations drive constitutive NRF2 activation and correlate with poor prognosis. Despite its apparent significance, a comprehensive catalogue of somatic NRF2 mutations across different tumor types is still lacking...
August 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30096301/comprehensive-molecular-characterization-of-muscle-invasive-bladder-cancer
#4
A Gordon Robertson, Jaegil Kim, Hikmat Al-Ahmadie, Joaquim Bellmunt, Guangwu Guo, Andrew D Cherniack, Toshinori Hinoue, Peter W Laird, Katherine A Hoadley, Rehan Akbani, Mauro A A Castro, Ewan A Gibb, Rupa S Kanchi, Dmitry A Gordenin, Sachet A Shukla, Francisco Sanchez-Vega, Donna E Hansel, Bogdan A Czerniak, Victor E Reuter, Xiaoping Su, Benilton de Sa Carvalho, Vinicius S Chagas, Karen L Mungall, Sara Sadeghi, Chandra Sekhar Pedamallu, Yiling Lu, Leszek J Klimczak, Jiexin Zhang, Caleb Choo, Akinyemi I Ojesina, Susan Bullman, Kristen M Leraas, Tara M Lichtenberg, Catherine J Wu, Nicholaus Schultz, Gad Getz, Matthew Meyerson, Gordon B Mills, David J McConkey, John N Weinstein, David J Kwiatkowski, Seth P Lerner
No abstract text is available yet for this article.
August 9, 2018: Cell
https://www.readbyqxmd.com/read/30081681/the-clinical-applications-of-the-cancer-genome-atlas-project-for-bladder-cancer
#5
Chad J Creighton
Knowledge of the molecular subtypes of bladder cancer enables powerful generalizations involving the distinctive biology and pathways driving different disease subsets. Areas covered: In this review, we summarize the findings of a number of published studies exploring the molecular landscape of bladder cancer by analysis of genomic data from The Cancer Genome Atlas (TCGA). TCGA project has provided a comprehensive data resource of 412 muscle-invasive bladder cancers as characterized by multiple molecular analytical platforms...
October 2018: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/30075204/trim65-supports-bladder-urothelial-carcinoma-cell-aggressiveness-by-promoting-anxa2-ubiquitination-and-degradation
#6
Wen-Su Wei, Xin Chen, Li-Yi Guo, Xiang-Dong Li, Ming-Hui Deng, Gang-Jun Yuan, Le-Ye He, Yong-Hong Li, Zhi-Lin Zhang, Li-Juan Jiang, Ri-Xin Chen, Xiao-Dan Ma, Shi Wei, Ning-Fang Ma, Zhuo-Wei Liu, Jun-Hang Luo, Fang-Jian Zhou, Dan Xie
Clinically, most of human urothelial carcinoma of the bladder (UCB)-related deaths result from tumor metastasis, but the underlying molecular mechanisms are largely unknown. Recently, a growing number of tripartite motif (TRIM) family members have been suggested to be important regulators for tumorigenesis. However, the impact of most TRIM members on UCB pathogenesis is unclear. In this study, TRIM65 was first screened as an important oncogenic factor of UCB from the Cancer Genome Atlas (TCGA) database and was validated by a large cohort of clinical UCB tissues...
October 28, 2018: Cancer Letters
https://www.readbyqxmd.com/read/30066919/increased-expression-of-tnfrsf14-indicates-good-prognosis-and-inhibits-bladder-cancer-proliferation-by-promoting-apoptosis
#7
Yu-Di Zhu, Ming-Yue Lu
Despite advances in management, bladder cancer remains a principal cause of cancer‑associated complications. Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) is dysregulated in certain types of cancer; however, limited data are available on the expression and function of TNFRSF14 in bladder cancer. In the present study, the aim was to evaluate the expression and biological functions of TNFRSF14 in bladder cancer. Firstly, the expression levels of TNFRSF14 in bladder cancer tissue were examined using The Cancer Genome Atlas (TCGA) database...
September 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30037718/using-micrornas-as-novel-predictors-of-urologic-cancer-survival-an-integrated-analysis
#8
Zhicong Chen, Yonghao Zhan, Jieshan Chi, Shuyuan Guo, Xinliang Zhong, Anbang He, Jianrong Zheng, Yanqing Gong, Xuesong Li, Liqun Zhou
BACKGROUND: MicroRNAs(miRNAs) are involved in the formation, maintenance, and metastasis of urologic cancer. Here, we aim to gather and evaluate all of the evidence regarding the potential role of miRNAs as novel predictors of urologic cancer survival. METHODS: A systematic review was performed to identify and score all of the published studies that evaluated the prognostic effects of miRNAs in kidney (KCa), bladder (BCa) or prostate cancer (PCa). Where appropriate, the summary effects of miRNAs on urologic cancer were meta-analysed...
August 2018: EBioMedicine
https://www.readbyqxmd.com/read/30026881/a-panel-of-microrna-signature-as-a-tool-for-predicting-survival-of-patients-with-urothelial-carcinoma-of-the-bladder
#9
Teruo Inamoto, Hirofumi Uehara, Yukihiro Akao, Naokazu Ibuki, Kazumasa Komura, Kiyoshi Takahara, Tomoaki Takai, Taizo Uchimoto, Kenkichi Saito, Naoki Tanda, Yuki Yoshikawa, Koichiro Minami, Hajime Hirano, Hayahito Nomi, Ryuji Kato, Tetsuya Hayashi, Haruhito Azuma
Introduction and Objectives: MicroRNA (miRNA) expression is altered in urologic malignancies, including urothelial carcinoma of the bladder (UCB). Individual miRNAs have been shown to modulate multiple signaling pathways that contribute to BC. To identify a panel of miRNA signature that can predict aggressive phenotype from normal nonaggressive counterpart using miRNA expression levels and to assess the prognostic value of this specific miRNA markers in patients with UCB. Methods: To determine candidate miRNAs as prognostic biomarkers for dividing aggressive type of UCB, miRNA expression was profiled in patients' samples with an aggressive phenotype or nonaggressive phenotype using 3D-Gene miRNA labeling kit (Toray, Japan)...
2018: Disease Markers
https://www.readbyqxmd.com/read/30008905/a-risk-score-staging-system-based-on-the-expression-of-seven-genes-predicts-the-outcome-of-bladder-cancer
#10
Jianfeng Chu, Ning Li, Fengguang Li
Bladder cancer (BLCA) is among the most malignant types of cancer. At present, the prognostic tools available for this disease are insufficient. In the present study, the transcriptome of 1,049 BLCA samples from four datasets from the Gene Expression Omnibus and The Cancer Genome Atlas (TCGA) were analyzed. By utilizing the RNA-seq data provided by TCGA, a risk score staging system model was built to predict the outcome of patients with BLCA using random forest variable hunting and Cox multivariate regression...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30006603/hippo-pathway-affects-survival-of-cancer-patients-extensive-analysis-of-tcga-data-and-review-of-literature
#11
Anello Marcello Poma, Liborio Torregrossa, Rossella Bruno, Fulvio Basolo, Gabriella Fontanini
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progression. Herein, we investigated the impact of 32 Hippo genes on overall survival (OS) of cancer patients, by both analysing data from The Cancer Genome Atlas (TCGA) and reviewing the related literature. mRNA and protein expression data of all solid tumors except pure sarcomas were downloaded from TCGA database. Thirty-two Hippo genes were considered; for each gene, patients were dichotomized based on median expression value...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29970902/identification-of-micror-106b-as-a-prognostic-biomarker-of-p53-like-bladder-cancers-by-actmir
#12
Eunjee Lee, Ana Collazo-Lorduy, Mireia Castillo-Martin, Yixuan Gong, Li Wang, William K Oh, Matthew D Galsky, Carlos Cordon-Cardo, Jun Zhu
Bladder cancers can be categorized into subtypes according to gene expression patterns. P53-like muscle-invasive bladder cancers are generally resistant to cisplatin-based chemotherapy, but exhibit heterogeneous clinical outcomes with a prognosis intermediate to that of the luminal and basal subtypes. The optimal approach to p53-like tumors remains poorly defined and better means to risk-stratify such tumors and identification of novel therapeutic targets is urgently needed. MicroRNAs (miRNAs) play a key role in cancer, both in tumorigenesis and tumor progression...
July 3, 2018: Oncogene
https://www.readbyqxmd.com/read/29949785/identification-of-carbonic-anhydrase-ix-as-a-novel-target-for-endoscopic-molecular-imaging-of-human-bladder-cancer
#13
RANDOMIZED CONTROLLED TRIAL
Jiaqi Wang, Ruizhe Fang, Lu Wang, Guang Chen, Hongzhi Wang, Zhichao Wang, Danfeng Zhao, Valentin N Pavlov, Ildar Kabirov, Ziqi Wang, Pengyu Guo, Li Peng, Wanhai Xu
BACKGROUND/AIMS: Emerging novel optical imaging techniques with cancer-specific molecular imaging agents offer a powerful and promising platform for cancer detection and resection. White-light cystoscopy and random bladder biopsies remain the most appropriate but nonetheless suboptimal diagnostic technique for bladder cancer, which is associated with high morbidity and recurrence. However, white-light cystoscopy has intrinsic shortcomings. Although current optical imaging technologies hold great potential for improved diagnostic accuracy, there are few imaging agents for specific molecular targeting...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29917141/tumor-cdkn2a-associated-jak2-loss-and-susceptibility-to-immunotherapy-resistance
#14
Susanne Horn, Sonia Leonardelli, Antje Sucker, Dirk Schadendorf, Klaus G Griewank, Annette Paschen
Poor clinical responses to checkpoint blockade with anti-CTLA-4 and anti-PD-1 antibodies in melanoma have recently been associated with acquired IFNγ resistance that protects tumor cells from the antiproliferative and pro-apoptotic cytokine activity. IFNγ-resistant melanoma cells very often lack functional expression of the IFNγ signaling pathway gene JAK2 due to gene deletions or inactivating gene mutations. Analyzing melanoma cell lines (n = 46, applying next-generation targeted sequencing and single nucleotide polymorphism arrays) as well as available genomic data sets from The Cancer Genome Atlas (TCGA) tumor tissue samples (cutaneous melanoma n = 367, lung squamous cell carcinoma n = 501, bladder urothelial carcinoma n = 408, breast invasive carcinoma n = 768, colorectal adenocarcinoma n = 257), we demonstrate that the frequent chromosomal losses of the tumor suppressor CDKN2A in melanoma and other tumor entities enhance the susceptibility to IFNγ resistance by concomitant deletion of the JAK2 gene (odds ratio = 223...
June 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29899832/subclassification-survival-prediction-and-drug-target-analyses-of-chemotherapy-na%C3%A3-ve-muscle-invasive-bladder-cancer-with-a-molecular-screening
#15
Sebastien Rinaldetti, Eugen Rempel, Thomas Stefan Worst, Markus Eckstein, Annette Steidler, Cleo Aaron Weiss, Christian Bolenz, Arndt Hartmann, Philipp Erben
Background: Transcriptome expression studies identified distinct muscle invasive bladder cancer (MIBC) subtypes closely related with breast cancer subclasses. Here we developed a sensitive quantification method for MIBC subclassification (luminal, basal, p53-like). In addition, the subtype specific expression of drug targets has been investigated. Methods: Absolute quantification (nCounter) of a 64-gene panel was performed on MIBC patients (n=47) treated exclusively with radical cystectomy (RC)...
May 25, 2018: Oncotarget
https://www.readbyqxmd.com/read/29888072/deep-learning-data-integration-for-better-risk-stratification-models-of-bladder-cancer
#16
Olivier B Poirion, Kumardeep Chaudhary, Lana X Garmire
We propose an unsupervised multi-omics integration pipeline, using deep-learning autoencoder algorithm, to predict the survival subtypes in bladder cancer (BC). We used TCGA dataset comprising mRNA, miRNA and methylation to infer two survival subtypes. We then constructed a supervised classification model to predict the survival subgroups of any new individual sample. Our training data gave two subgroups with significant survival differences (p-value=8e-4), where high-risk survival subgroup was enriched with KRT6/14 overexpression and PI3K-Akt pathways...
2018: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/29872319/an-integrated-analysis-of-key-micrornas-regulatory-pathways-and-clinical-relevance-in-bladder-cancer
#17
Dongyang Li, Xuanyu Hao, Yongsheng Song
Objective: The aim of this study was to identify the key microRNAs (miRNAs) and their regulatory networks in bladder cancer (BC). Materials and methods: Three miRNA and three gene expression microarray datasets were downloaded for analysis from Gene Expression Omnibus database. The differentially expressed miRNAs (DEMs) and differentially expressed genes (DEGs) were accessed by the use of GEO2R. Gene ontology process and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed by using the Database for Annotation, Visualization and Integrated Discovery program...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29858066/microrna-411-downregulation-enhances-tumor-growth-by-upregulating-mllt11-expression-in-human-bladder-cancer
#18
Honglei Jin, Wenrui Sun, Yuanmei Zhang, Huiying Yan, Huating Liufu, Shuai Wang, Caiyi Chen, Jiayan Gu, Xiaohui Hua, Lingli Zhou, Guosong Jiang, Dapang Rao, Qipeng Xie, Haishan Huang, Chuanshu Huang
Although several previous studies have reported the implication of various microRNAs (miRNAs) in regulation of human bladder cancer (BC) development, alterations and function of many miRNAs in bladder cancer growth are not explored yet at present. Here, we screened 1,900 known miRNAs and first discovered that miR-411 was one of the major miRNAs, which was down-regulated in n-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced BCs. This miR-411 down-regulation was also observed in human BC tissues and cell lines...
June 1, 2018: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/29769742/modified-citrus-pectin-inhibited-bladder-tumor-growth-through-downregulation-of-galectin-3
#19
Tian Fang, Dan-Dan Liu, He-Ming Ning, Dan Liu, Jing-Ya Sun, Xiao-Jing Huang, Yu Dong, Mei-Yu Geng, Shi-Feng Yun, Jun Yan, Rui-Min Huang
Modified citrus pectin (MCP) is a carbohydrate enriched complex, which has been implicated in cancer treatment and prevention. However, the effects of MCP on urinary bladder cancer (UBC) are unknown. In this study, MCP was first tested in T24 and J82 human UBC cells and showed the inhibition of cell viability by the sulforhodamine B (SRB) assay. The MCP-treated UBC cells exhibited G2 /M phase arrest with the decrease of Cyclin B1 and phosphorylated Cdc2. Caspase-3 was also activated, leading to the cleavage of Caspase-3 and PARP...
May 16, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29725414/upregulated-gaplinc-predicts-a-poor-prognosis-in-bladder-cancer-patients-and-promotes-tumor-proliferation-and-invasion
#20
Zaosong Zheng, Dingjun Zhu, Fengjin Zhao, Jinli Han, Haicheng Chen, Yuhong Cai, Wenlian Xie
Previous studies have demonstrated that long noncoding RNAs (lncRNAs) exhibit critical regulatory roles in cancer biology. However, few lncRNAs have been well characterized in bladder cancer. In the previous study, we demonstrated that gastric adenocarcinoma associated, positive CD44 regulator, long intergenic noncoding RNA (GAPLINC) was significantly upregulated in bladder cancer tissues compared with normal tissues in The Cancer Genome Atlas (TCGA) cohort (P=0.039) and a validated cohort of 80 patients with bladder cancer (P=0...
May 2018: Oncology Letters
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