Antonella Gagliano, Federica Murgia, Agata Maria Capodiferro, Marcello Giuseppe Tanca, Aran Hendren, Stella Giulia Falqui, Michela Aresti, Martina Comini, Sara Carucci, Eleonora Cocco, Lorena Lorefice, Michele Roccella, Luigi Vetri, Stefano Sotgiu, Alessandro Zuddas, Luigi Atzori
We recently described a unique plasma metabolite profile in subjects with pediatric acute-onset neuropsychiatric syndrome (PANS), suggesting pathogenic models involving specific patterns of neurotransmission, neuroinflammation, and oxidative stress. Here, we extend the analysis to a group of patients with autism spectrum disorder (ASD), as a consensus has recently emerged around its immune-mediated pathophysiology with a widespread involvement of brain networks. This observational case-control study enrolled patients referred for PANS and ASD from June 2019 to May 2020, as well as neurotypical age and gender-matched control subjects...
November 1, 2022: Journal of Clinical Medicine