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precision stroke

Chanapai Chaiyakulsil, Marut Chantra, Poomiporn Katanyuwong, Anant Khositseth, Nattachai Anantasit
INTRODUCTION: Hemodynamic parameters measurements were widely conducted using pulmonary artery catheter (PAC) with thermodilution as a reference standard. Due to its technical difficulties in children, transthoracic echocardiography (TTE) has been widely employed instead. Nonetheless, TTE requires expertise and is time-consuming. Noninvasive cardiac output monitoring such as ultrasonic cardiac output monitor (USCOM) and electrical velocimetry (EV) can be performed rapidly with less expertise requirement...
2018: PloS One
David S Liebeskind
No abstract text is available yet for this article.
July 2018: Critical Care Medicine
R Saghir, G Humm, T Rix
Introduction A recognised complication of carotid endarterectomy (CEA) is postoperative haematoma, which can threaten the airway. Previous studies have looked at medical methods of preventing this complication. This study aims to evaluate the impact of simple direct pressure postoperatively on the development of haematoma. Materials and methods From 2011 to 2016, 161 consecutive CEA were performed by a single surgeon or trainee under supervision. After 80 operations, the postoperative technique was altered, with additional pressure being applied by the surgeon to the skin incision from completion of suturing until each patient was awake in the recovery room...
June 18, 2018: Annals of the Royal College of Surgeons of England
Casey Rosen, Larissa McKetton, Jeremy Russell, Kevin Sam, Julien Poublanc, Adrian Crawley, Jay S Han, Olivia Sobczyk, James Duffin, Danny M Mandell, Michael Tymianski, Joseph A Fisher, David J Mikulis, Lashmi Venkatraghavan
The purpose of this retrospective observational study is to investigate the long-term changes in cerebrovascular reactivity (CVR) as a measure of cerebral hemodynamics in patients with intracranial steno-occlusive disease (IC-SOD) after they have undergone an Extracranial-intracranial (EC-IC) bypass. Twenty-six patients suffering from IC-SOD were selected from our CVR database. Nineteen patients underwent unilateral and 7 underwent bilateral revascularization. CVR measurements were done using BOLD-MRI and precisely controlled CO2 and expressed as ΔBOLD (%)/Δ PET CO2 (mmHg)...
June 12, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Qi-Wen Deng, Shuo Li, Huan Wang, Leix Lei, Han-Qing Zhang, Zheng-Tian Gu, Fang-Lan Xing, Fu-Ling Yan
The triglyceride (TG)-to-high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) is a simple approach to predicting unfavorable outcomes in cardiovascular disease. The influence of TG/HDL-C on acute ischemic stroke remains elusive. The purpose of this study was to investigate the precise effect of TG/HDL-C on 3-month mortality after acute ischemic stroke (AIS). Patients with AIS were enrolled in the present study from 2011 to 2017. A total of 1459 participants from a single city in China were divided into retrospective training and prospective test cohorts...
June 2018: Aging and Disease
Xiangrong Liu, Shaohong Wen, Shunying Zhao, Feng Yan, Shangfeng Zhao, Di Wu, Xunming Ji
Mild therapeutic hypothermia, a robust neuroprotectant, reduces neuronal apoptosis, but the precise mechanism is not well understood. Our previous study showed that a novel inhibitor of an apoptosis-stimulating protein of p53 (iASPP) might be involved in neuronal death after stroke. The aim of this study was to confirm the role of iASPP after stroke treated with mild therapeutic hypothermia. To address this, we mimicked ischemia/reperfusion injury in vitro by using oxygen-glucose deprivation/reperfusion (OGD/R) in primary rat neurons...
June 2018: Aging and Disease
Gyeong Bok Jung, Sung Wook Kang, Gi-Ja Lee, Dohyun Kim
Cerebral ischemic stroke is one of the most common neurodegenerative conditions characterized by cerebral infarction, death of the brain tissue, and loss of brain function. Cerebral ischemia-reperfusion injury is the tissue damage caused when blood supply begins to the tissue after a period of ischemia or poor oxygen supply. In this study, we preliminarily investigated the biochemical changes in the brain hippocampal area, CA1, resulting from ischemia reperfusion and neuronal nitric oxide synthase (nNOS) inhibitor treatment in rats using Raman spectroscopy...
January 1, 2018: Applied Spectroscopy
Fengyang Wang, Shujuan Yu, Zhiai Xu, Lingling Li, Yijing Dang, Xiaowei Xu, Yi Luo, Zhen Cheng, Haijun Yu, Wen Zhang, Ao Zhang, Chunyong Ding
To accurately monitor the variations of lysosomal nitric oxide (NO) under physiological condition remains a great challenge for understanding the biological function of NO. Herein, we developed a new chemotype probe, namely, MBTD, for acid-promoted and far-red fluorescence imaging of lysosomal NO in vitro and ex vivo. MBTD was rationally designed by incorporating o-phenylenediamino (OPD) moiety into the donor-acceptor-donor (D-A-D) type fluorophore based on a dual intramolecular charge transfer (ICT) mechanism...
June 11, 2018: Analytical Chemistry
Satoshi Hori, Daina Kashiwazaki, Shusuke Yamamoto, Güliz Acker, Marcus Czabanka, Naoki Akioka, Naoya Kuwayama, Peter Vajkoczy, Satoshi Kuroda
BACKGROUND: Fragile, dilated moyamoya vessels are the main source of hemorrhagic stroke in moyamoya disease (MMD). However, the prevalence of hemorrhagic stroke largely differs between Asian and western countries, although the underlying pathophysiology has not been clarified. OBJECTIVE: To systematically analyze the difference of collateral angioarchitectures between Japanese and European Caucasians with MMD. METHODS: This study included 71 patients with MMD, including Japanese (n = 41) and European Caucasians (n = 30)...
June 8, 2018: Neurosurgery
G B Praveen, Anita Agrawal, Ponraj Sundaram, Sanjay Sardesai
Automatic segmentation of ischemic stroke lesion volumes from multi-spectral Magnetic Resonance Imaging (MRI) sequences plays a vital role in quantifying and locating the lesion region. Most existing methods mainly rely on designing hand-crafted features followed by a classifier model for ischemic stroke lesion segmentation. Design of these features requires complex domain knowledge and often lacks the ability to differentiate between the stroke lesions and the normal classes. In this work, we propose an unsupervised featured learning approach based on stacked sparse autoencoder (SSAE) framework for automatically learning the features for accurate segmentation of stroke lesions from brain MR images...
June 2, 2018: Computers in Biology and Medicine
Kiran Musunuru, Farah Sheikh, Rajat M Gupta, Steven R Houser, Kevin O Maher, David J Milan, Andre Terzic, Joseph C Wu
Induced pluripotent stem cells (iPSCs) offer an unprece-dented opportunity to study human physiology and disease at the cellular level. They also have the potential to be leveraged in the practice of precision medicine, for example, personalized drug testing. This statement comprehensively describes the provenance of iPSC lines, their use for cardiovascular disease modeling, their use for precision medicine, and strategies through which to promote their wider use for biomedical applications. Human iPSCs exhibit properties that render them uniquely qualified as model systems for studying human diseases: they are of human origin, which means they carry human genomes; they are pluripotent, which means that in principle, they can be differentiated into any of the human body's somatic cell types; and they are stem cells, which means they can be expanded from a single cell into millions or even billions of cell progeny...
January 2018: Circulation. Genomic and precision medicine
Netha Hussain, Margit Alt Murphy, Katharina S Sunnerhagen
Background: Kinematic analysis using virtual reality (VR) environment provides quantitative assessment of upper limb movements. This technique has rarely been used in evaluating motor function in stroke despite its availability in stroke rehabilitation. Objective: To determine the discriminative validity of VR-based kinematics during target-to-target pointing task in individuals with mild or moderate arm impairment following stroke and in healthy controls. Methods: Sixty-seven participants with moderate (32-57 points) or mild (58-65 points) stroke impairment as assessed with Fugl-Meyer Assessment for Upper Extremity were included from the Stroke Arm Longitudinal study at the University of Gothenburg-SALGOT cohort of non-selected individuals within the first year of stroke...
2018: Frontiers in Neurology
Smriti Agarwal, Giacomo Koch, Argye E Hillis, William Huynh, Nick S Ward, Steve Vucic, Matthew C Kiernan
Transcranial magnetic stimulation (TMS) is an accessible, non-invasive technique to study cortical function in vivo. TMS studies have provided important pathophysiological insights across a range of neurodegenerative disorders and enhanced our understanding of brain reorganisation after stroke. In neurodegenerative disease, TMS has provided novel insights into the function of cortical output cells and the related intracortical interneuronal networks. Characterisation of cortical hyperexcitability in amyotrophic lateral sclerosis and altered motor cortical function in frontotemporal dementia, demonstration of cholinergic deficits in Alzheimer's disease and Parkinson's disease are key examples where TMS has led to advances in understanding of disease pathophysiology and potential mechanisms of propagation, with the potential for diagnostic applications...
June 4, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
Kiefer James Forseth, Cihan Mehmet Kadipasaoglu, Christopher Richard Conner, Gregory Hickok, Robert Thomas Knight, Nitin Tandon
Semantic memory underpins our understanding of objects, people, places, and ideas. Anomia, a disruption of semantic memory access, is the most common residual language disturbance and is seen in dementia and following injury to temporal cortex. While such anomia has been well characterized by lesion symptom mapping studies, its pathophysiology is not well understood. We hypothesize that inputs to the semantic memory system engage a specific heteromodal network hub that integrates lexical retrieval with the appropriate semantic content...
May 30, 2018: Brain: a Journal of Neurology
Linn Beate Strand, Min Kuang Tsai, Chi Pang Wen, Shu-Sen Chang, Ben M Brumpton
OBJECTIVES: A significant proportion of cardiovascular disease (CVD) cannot be explained by well-known risk factors such as high cholesterol, hypertension and diabetes. One potential novel risk factor for CVD is asthma. We aimed to investigate the association between asthma and mortality due to CVD. DESIGN: Prospective cohort study. SETTING: A large health check-up programme from 1994 to 2011 in Taipei, Taiwan. PARTICIPANTS: 446 346 Taiwanese adults...
May 31, 2018: BMJ Open
Kiran Musunuru, Pankaj Arora, John P Cooke, Jane F Ferguson, Ray E Hershberger, Kathleen T Hickey, Jin-Moo Lee, João A C Lima, Joseph Loscalzo, Naveen L Pereira, Mark W Russell, Svati H Shah, Farah Sheikh, Thomas J Wang, Calum A MacRae
The completion of the Human Genome Project has unleashed a wealth of human genomics information, but it remains unclear how best to implement this information for the benefit of patients. The standard approach of biomedical research, with researchers pursuing advances in knowledge in the laboratory and, separately, clinicians translating research findings into the clinic as much as decades later, will need to give way to new interdisciplinary models for research in genomic medicine. These models should include scientists and clinicians actively working as teams to study patients and populations recruited in clinical settings and communities to make genomics discoveries-through the combined efforts of data scientists, clinical researchers, epidemiologists, and basic scientists-and to rapidly apply these discoveries in the clinic for the prediction, prevention, diagnosis, prognosis, and treatment of cardiovascular diseases and stroke...
June 2018: Circulation. Genomic and precision medicine
Jing Lin, Zhao Han, Chun Wang, Xingyang Yi, Zhenxiao Chai, Qiang Zhou, Ruyue Huang
PURPOSE: To investigate the associations between CYP2C19 genotypes and early neurological deterioration (END), and to carry out a stratified analysis of the effectiveness of clopidogrel alone and dual antiplatelet therapy with clopidogrel and aspirin for prevention of END according to CYP2C19 genotypes in ischemic stroke (IS) patients. METHODS: This was a prospective, observational, two-center study. A total of 375 acute IS patients were enrolled. Platelet aggregation was measured before and after the 7- to 10-day treatment...
May 26, 2018: European Journal of Clinical Pharmacology
Dan Koto, Masaki Izumo, Takafumi Machida, Kengo Suzuki, Kihei Yoneyama, Tomomi Suzuki, Ryo Kamijima, Yasuyuki Kobayashi, Tomoo Harada, Yoshihiro J Akashi
BACKGROUND: It is unclear how upper septal hypertrophy (USH) affects Doppler-derived left ventricular stroke volume (SV) in patients with AS. The aims of this study were to: (1) validate the accuracy of 3D transesophageal echocardiography (TEE) measurements of the left ventricular outflow tract (LVOT), (2) evaluate the differences in LVOT geometry between AS patients with and without USH, and (3) assess the impact of USH on measurement of SV. METHODS: In protocol 1, both 3D TEE and multi-detector computed tomography were performed in 20 patients with AS [aortic valve area (AVA) ≤ 1...
May 24, 2018: Journal of Echocardiography
Sophie Cleanthous, Sara Strzok, Farrah Pompilus, Stefan Cano, Patrick Marquis, Stanley Cohan, Myla D Goldman, Kiren Kresa-Reahl, Jennifer Petrillo, Carmen Castrillo-Viguera, Diego Cadavid, Shih-Yin Chen
Background: ABILHAND, a manual ability patient-reported outcome instrument originally developed for stroke patients, has been used in multiple sclerosis clinical trials; however, psychometric analyses indicated the measure's limited measurement range and precision in higher-functioning multiple sclerosis patients. Objective: The purpose of this study was to identify candidate items to expand the measurement range of the ABILHAND-56, thus improving its ability to detect differences in manual ability in higher-functioning multiple sclerosis patients...
April 2018: Multiple Sclerosis Journal—Experimental, Translational and Clinical
Marielle Lebrun, Julien Lambert, Laura Riva, Nicolas Thelen, Xavier Rambout, Caroline Blondeau, Marc Thiry, Robert Snoeck, Jean-Claude Twizere, Franck Dequiedt, Graciela Andrei, Catherine Sadzot-Delvaux
ORF9p (homologous to HSV-1 VP22) is a varicella-zoster virus (VZV) tegument protein essential for viral replication. Even though its precise functions are far from being fully described, a role in the secondary envelopment of the virus has long been suggested. We performed a yeast two-hybrid screen to identify cellular proteins interacting with ORF9p that might be important for this function. We found thirty-one ORF9p interaction partners, among which AP1M1, the μ subunit of the adaptor protein complex-1 (AP-1)...
May 23, 2018: Journal of Virology
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