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https://www.readbyqxmd.com/read/29237706/patient-characteristics-resource-use-and-outcomes-associated-with-general-internal-medicine-hospital-care-the-general-medicine-inpatient-initiative-gemini-retrospective-cohort-study
#1
Amol A Verma, Yishan Guo, Janice L Kwan, Lauren Lapointe-Shaw, Shail Rawal, Terence Tang, Adina Weinerman, Peter Cram, Irfan A Dhalla, Stephen W Hwang, Andreas Laupacis, Muhammad M Mamdani, Steven Shadowitz, Ross Upshur, Robert J Reid, Fahad Razak
BACKGROUND: The precise scope of hospital care delivered under general internal medicine services remains poorly quantified. The purpose of this study was to describe the demographic characteristics, medical conditions, health outcomes and resource use of patients admitted to general internal medicine at 7 hospital sites in the Greater Toronto Area. METHODS: This was a retrospective cohort study involving all patients who were admitted to or discharged from general internal medicine at the study sites between Apr...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29230366/comparison-between-radial-artery-tonometry-pulse-analyzer-and-pulsed-doppler-echocardiography-derived-hemodynamic-parameters-in-cardiac-surgery-patients-a-pilot-study
#2
Rashad Zayat, Andreas Goetzenich, Ju-Yeon Lee, HeeJung Kang, So-Hyun Jansen-Park, Thomas Schmitz-Rode, Giulia Musetti, Heike Schnoering, Rüdiger Autschbach, Nima Hatam, Ali Aljalloud
Background: Bedside non-invasive techniques, such as radial artery tonometry, to estimate hemodynamic parameters have gained increased relevance as an attractive alternative and efficient method to measure hemodynamics in outpatient departments. For our pilot study, we sought to compare cardiac output (CO), and stroke volume (SV) estimated from a radial artery tonometry blood pressure pulse analyzer (BPPA) (DMP-Life, DAEYOMEDI Co., Gyeonggi-do, South Korea) to pulsed-wave Doppler (PWD) echocardiography derived parameters...
2017: PeerJ
https://www.readbyqxmd.com/read/29230275/the-efficacy-of-a-haptic-enhanced-virtual-reality-system-for-precision-grasp-acquisition-in-stroke-rehabilitation
#3
Shih-Ching Yeh, Si-Huei Lee, Rai-Chi Chan, Yi Wu, Li-Rong Zheng, Sheryl Flynn
Stroke is a leading cause of long-term disability, and virtual reality- (VR-) based stroke rehabilitation is effective in increasing motivation and the functional performance. Although much of the functional reach and grasp capabilities of the upper extremities were regained, the pinch movement remains impaired following stroke. In this study, we developed a haptic-enhanced VR system to simulate haptic pinch tasks to assist the recovery of upper-extremity fine motor function. We recruited 16 adults with stroke to verify the efficacy of this new VR system...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29225622/correlation-between-ch2ds2-vasc-score-and-serum-leptin-levels-in-cardioembolic-stroke-patients-the-impact-of-metabolic-syndrome
#4
Anna Szczepańska-Szerej, Jacek Kurzepa, Aneta Grabarska, Joanna Bielewicz, Ewa Wlizło-Dyś, Konrad Rejdak
Objective: To determine adipokines levels in patients with different etiologic subtypes of acute ischemic stroke (AIS) and metabolic syndrome (MetS) status. Methods: Serum adiponectin, leptin, and resistin levels were determined by ELISA in 99 AIS patients and 59 stroke-free control group subjects. Stroke patients were grouped based on MetS, modified TOAST classification, and CHA2DS2-VASc scale in case of cardioembolic stroke following atrial fibrillation. Results: No differences were found in all adipokine serum levels between AIS patients and appropriately matched control group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29222738/ct-based-3d-printing-is-superior-to-transesophageal-echocardiography-for-pre-procedure-planning-in-left-atrial-appendage-device-closure
#5
Edinrin Obasare, Sumeet K Mainigi, D Lynn Morris, Leandro Slipczuk, Igor Goykhman, Evan Friend, Mary Rodriguez Ziccardi, Gregg S Pressman
Accurate assessment of the left atrial appendage (LAA) is important for pre-procedure planning when utilizing device closure for stroke reduction. Sizing is traditionally done with transesophageal echocardiography (TEE) but this is not always precise. Three-dimensional (3D) printing of the LAA may be more accurate. 24 patients underwent Watchman device (WD) implantation (71 ± 11 years, 42% female). All had complete 2-dimensional TEE. Fourteen also had cardiac computed tomography (CCT) with 3D printing to produce a latex model of the LAA for pre-procedure planning...
December 8, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29215082/the-myokinetic-control-interface-tracking-implanted-magnets-as-a-means-for-prosthetic-control
#6
S Tarantino, F Clemente, D Barone, M Controzzi, C Cipriani
Upper limb amputation deprives individuals of their innate ability to manipulate objects. Such disability can be restored with a robotic prosthesis linked to the brain by a human-machine interface (HMI) capable of decoding voluntary intentions, and sending motor commands to the prosthesis. Clinical or research HMIs rely on the interpretation of electrophysiological signals recorded from the muscles. However, the quest for an HMI that allows for arbitrary and physiologically appropriate control of dexterous prostheses, is far from being completed...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29208020/mapping-upper-limb-motor-performance-after-stroke-a-novel-method-with-utility-for-individualized-motor-training
#7
Orna Rosenthal, Alan M Wing, Jeremy L Wyatt, David Punt, R Chris Miall
BACKGROUND: Chronic upper limb motor impairment is a common outcome of stroke. Therapeutic training can reduce motor impairment. Recently, a growing interest in evaluating motor training provided by robotic assistive devices has emerged. Robot-assisted therapy is attractive because it provides a means of increasing practice intensity without increasing the workload of physical therapists. However, movements practised through robotic assistive devices are commonly pre-defined and fixed across individuals...
December 6, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29202444/evaluation-of-the-hospital-anxiety-and-depression-scale-hads-in-screening-stroke-patients-for-symptoms-item-response-theory-irt-analysis
#8
Salma A Ayis, Luis Ayerbe, Mark Ashworth, Charles DA Wolfe
BACKGROUND: Variations have been reported in the number of underlying constructs and choice of thresholds that determine caseness of anxiety and /or depression using the Hospital Anxiety and Depression scale (HADS). This study examined the properties of each item of HADS as perceived by stroke patients, and assessed the information these items convey about anxiety and depression between 3 months to 5 years after stroke. METHODS: The study included 1443 stroke patients from the South London Stroke Register (SLSR)...
November 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29201639/visual-feedback-alters-force-control-and-functional-activity-in-the-visuomotor-network-after-stroke
#9
Derek B Archer, Nyeonju Kang, Gaurav Misra, Shannon Marble, Carolynn Patten, Stephen A Coombes
Modulating visual feedback may be a viable option to improve motor function after stroke, but the neurophysiological basis for this improvement is not clear. Visual gain can be manipulated by increasing or decreasing the spatial amplitude of an error signal. Here, we combined a unilateral visually guided grip force task with functional MRI to understand how changes in the gain of visual feedback alter brain activity in the chronic phase after stroke. Analyses focused on brain activation when force was produced by the most impaired hand of the stroke group as compared to the non-dominant hand of the control group...
2018: NeuroImage: Clinical
https://www.readbyqxmd.com/read/29200974/stroke-volume-monitoring-novel-continuous-wave-doppler-parameters-algorithms-and-advanced-noninvasive-haemodynamic-concepts
#10
REVIEW
R A Phillips, B E Smith, V M Madigan
Purpose of Review: Adequate oxygen delivery is essential for life, with hypoxia resulting in dysfunction, and ultimately death, of the cells, organs and organism. Blood flow delivers the oxygen bound in the blood, while haemodynamics is the science of blood flow. Stroke volume (SV) is the fundamental unit of blood flow, and reflects the interdependent performance of the heart, the vessels and the autonomic nervous system. However, haemodynamic management remains generally poor and predominantly guided by simple blood pressure observations alone...
2017: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29191525/apixaban-in-the-prevention-of-stroke-and-systemic-embolism-in-patients-with-non-valvular-atrial-fibrillation-in-france-rationale-and-design-of-the-paros-cross-sectional-study
#11
Fabien Picard, Gregory Ducrocq, Nicolas Danchin, Bruno Falissard, Olivier Hanon, Isabelle Mahe, Emmanuel Touzé, Philippe Gabriel Steg
BACKGROUND: Atrial fibrillation (AF) is the most common arrhythmia worldwide, and its prevalence is expected to increase with population ageing. The use of vitamin K antagonists (VKAs) for the prevention of stroke and/or systemic embolism in patients with non-valvular atrial fibrillation (NVAF) was recently challenged by non-VKA oral anticoagulants (NOACs), demonstrating a favourable risk-benefit profile, with reductions in stroke, intracranial haemorrhage and mortality, similar major bleeding, but increased gastrointestinal bleeding...
November 27, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29187583/mir-375-attenuates-injury-of-cerebral-ischemia-reperfusion-via-targeting-ctgf
#12
Jianying Ou, Li Kou, Lingyan Liang, Chaogang Tang
Ischemic stroke is the leading cause of disability and death worldwide. MicroRNAs have been shown to play an important role in development and pathogenesis of the nervous system. However, the precise function and mechanism of miRNAs are not fully understood in the brain injury induced by ischemia/reperfusion (I/R). Herein, our study showed that miR-375 expression was significantly down-regulated in the rat I/R brain. With the in vivo and in vitro I/R stroke models we found that miR-375 mimic provides significant protection from injury of cerebral I/R, which is reflected by reduced infarct volumes and cell apoptosis, increased proliferation and migration of PC12 cells...
November 29, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29179561/development-and-validation-of-the-activities-of-daily-living-short-form-for-community-dwelling-korean-stroke-survivors
#13
Ickpyo Hong, Eun-Young Yoo, Abby Swanson Kazley, Danbi Lee, Chih-Ying Li, Timothy A Reistetter
This study developed and validated a short form (SF) using activities of daily living (ADL) outcome measures from the Korea National Health and Nutrition Examination Survey (KNHANES) that can minimize survey administration burden for clinicians. This study utilized secondary data from the 2005 KNHANES with 422 community-dwelling stroke survivors. The KNHANES data were collected from April to June 2005 in South Korea. We created a 7-item SF from the 17 ADL questions in the survey using item response theory (IRT) methodologies...
January 1, 2017: Evaluation & the Health Professions
https://www.readbyqxmd.com/read/29170312/15%C3%A2-a-clinical-decision-tool-for-prescribing-anti-platelet-medication-for-patients-with-suspected-acute-coronary-syndrome-pam
#14
Charles Reynard, Rick Body
BACKGROUND: The benefit of antiplatelet medication in confirmed acute coronary syndrome (ACS) is well established. In the Emergency Department (ED) diagnostic uncertainty may lead to over-treatment, with consequent risks (e.g., bleeding), or under-treatment, compromising clinical outcomes. Clinicians must subjectively balance the anticipated risks and benefits with their perceived probability of ACS in order to decide whether to prescribe these medications. We aimed to construct a clinical model to optimise and personalise recommendations for anti-platelet prescription in this context...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29161264/proprioceptive-assessment-in-clinical-settings-evaluation-of-joint-position-sense-in-upper-limb-post-stroke-using-a-robotic-manipulator
#15
Sara Contu, Asif Hussain, Simone Kager, Aamani Budhota, Vishwanath A Deshmukh, Christopher W K Kuah, Lester H L Yam, Liming Xiang, Karen S G Chua, Lorenzo Masia, Domenico Campolo
Proprioception is a critical component for motor functions and directly affects motor learning after neurological injuries. Conventional methods for its assessment are generally ordinal in nature and hence lack sensitivity. Robotic devices designed to promote sensorimotor learning can potentially provide quantitative precise, accurate, and reliable assessments of sensory impairments. In this paper, we investigate the clinical applicability and validity of using a planar 2 degrees of freedom robot to quantitatively assess proprioceptive deficits in post-stroke participants...
2017: PloS One
https://www.readbyqxmd.com/read/29151041/assessment-of-thrombus-length-in-acute-ischemic-stroke-by-post-contrast-magnetic-resonance-angiography
#16
Ramanan Ganeshan, Alexander H Nave, Jan F Scheitz, Katharina A Schindlbeck, Karl Georg Haeusler, Christian H Nolte, Kersten Villringer, Jochen B Fiebach
OBJECTIVES: Post-contrast magnetic resonance angiography (PC-MRA) enables visualization of vessel segments distal to an intra-arterial thrombus in acute ischemic stroke. We hypothesized that PC-MRA also allows clot length measurement in different intracranial vessels. METHODS: Patients with MRI-confirmed ischemic stroke and intracranial artery occlusion within 24 hours of symptom onset were prospectively evaluated. PC-MRA was added to a standard stroke MRI protocol...
November 18, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/29143207/contribution-of-eeg-in-transient-neurological-deficits
#17
Pierre Lozeron, Nadine Carole Tcheumeni, Sahar Turki, Hélène Amiel, Elodie Meppiel, Sana Masmoudi, Caroline Roos, Isabelle Crassard, Patrick Plaisance, Houria Benbetka, Jean-Pierre Guichard, Emmanuel Houdart, Hélène Baudoin, Nathalie Kubis
Identification of stroke mimics and 'chameleons' among transient neurological deficits (TND) is critical. Diagnostic workup consists of a brain imaging study, for a vascular disease or a brain tumour and EEG, for epileptiform discharges. The precise role of EEG in this diagnostic workup has, however, never been clearly delineated. However, this could be crucial in cases of atypical or incomplete presentation with consequences on disease management and treatment. We analysed the EEG patterns on 95 consecutive patients referred for an EEG within 7 days of a TND with diagnostic uncertainty...
November 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29133297/evaluating-the-triplet-hypothesis-during-rhythmic-mastication-in-primates
#18
Yashesvini Ram, Callum F Ross
Mammalian mastication involves precise jaw movements including transverse movement of the mandible during the power stroke. Jaw elevation and transverse movement are driven by asymmetrical jaw elevator muscle activity which is thought to include a phylogenetically primitive and conserved triplet motor pattern consisting of: triplet I-balancing side superficial masseter and medial pterygoid, working side posterior temporalis- which reaches onset, peak, and offset first; and triplet II-working side superficial masseter and medial pterygoid, balancing side posterior temporalis-which is active second...
November 13, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29122653/validation-of-an-automated-bilateral-feet-cold-pressor-test
#19
Petra Bachmann, Xinwei Zhang, Mauro F Larra, Dagmar Rebeck, Karsten Schönbein, Klaus P Koch, Hartmut Schächinger
The Cold Pressor Test (CPT) is often used in psychobiological research. However, the classical CPT version (unilateral hand immersion into ice-water) involves some disadvantages: hands may be needed for further applications, attentional drift towards the affected sensory hemi-field and/or physiological activation of the contralateral hemisphere may produce a laterality bias. Furthermore, instruction-induced motor activity may bias physiologic reactivity. To avoid these problems, a fully automated bilateral feet CPT was developed and tested for validity and feasibility...
November 6, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29114077/the-ubiquitin-e3-ligase-traf6-exacerbates-ischemic-stroke-by-ubiquitinating-and-activating-rac1
#20
Tao Li, Juan-Juan Qin, Xia Yang, Yan-Xiao Ji, Fangliang Guo, Wen-Lin Cheng, Xiaolin Wu, Fu-Han Gong, Ying Hong, Xue-Yong Zhu, Jun Gong, Zhihua Wang, Zan Huang, Zhi-Gang She, Hongliang Li
Stroke is one of the leading causes of morbidity and mortality worldwide. Inflammation, oxidative stress, apoptosis, and excitotoxicity contribute to neuronal death during ischemic stroke; however, the mechanisms underlying these complicated pathophysiological processes remain to be fully elucidated. Here, we found that the expression of tumor necrosis factor receptor-associated factor 6 (TRAF6) was markedly increased after cerebral ischemia/reperfusion (I/R) in mice. TRAF6 ablation in male mice decreased the infarct volume and neurological deficit scores, and decreased pro-inflammatory signaling, oxidative stress and neuronal death after cerebral I/R, whereas transgenic overexpression of TRAF6 in male mice exhibited opposite effects...
November 7, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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