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https://www.readbyqxmd.com/read/27914088/murine-mycobacterium-marinum-infection-as-a-model-for-tuberculosis
#1
Julia Lienard, Fredric Carlsson
Mycobacteria are a major human health problem globally. Regarding tuberculosis the situation is worsened by the poor efficacy of current vaccine regimens and by emergence of drug-resistant strains (Manjelievskaia J et al, Trans R Soc Trop Med Hyg 110: 110, 2016; Pereira et al., Lancet Infect Dis 12:300-306, 2012; http://www.who.int/tb/publications/global_report/en/) undermining both disease-prevention and available treatments. Thus, increased basic understanding of mycobacterial-and particularly Mycobacterium tuberculosis-virulence strategies and pathogenesis is of great importance...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27914056/parallel-computational-protein-design
#2
Yichao Zhou, Bruce R Donald, Jianyang Zeng
Computational structure-based protein design (CSPD) is an important problem in computational biology, which aims to design or improve a prescribed protein function based on a protein structure template. It provides a practical tool for real-world protein engineering applications. A popular CSPD method that guarantees to find the global minimum energy solution (GMEC) is to combine both dead-end elimination (DEE) and A* tree search algorithms. However, in this framework, the A* search algorithm can run in exponential time in the worst case, which may become the computation bottleneck of large-scale computational protein design process...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27911945/correction-hmgb1-rage-axis-makes-no-contribution-to-cardiac-remodeling-induced-by-pressure-overload
#3
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0158514.].
2016: PloS One
https://www.readbyqxmd.com/read/27907209/correction-climate-demography-and-zoogeography-predict-introgression-thresholds-in-salmonid-hybrid-zones-in-rocky-mountain-streams
#4
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0163563.].
2016: PloS One
https://www.readbyqxmd.com/read/27907164/correction-national-prociency-testing-result-of-cyp2d6-10-genotyping-for-adjuvant-tamoxifen-therapy-in-china
#5
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0162361.].
2016: PloS One
https://www.readbyqxmd.com/read/27907149/correction-a-novel-colonial-ciliate-zoothamnium-ignavum-sp-nov-ciliophora-oligohymenophorea-and-its-ectosymbiont-candidatus-navis-piranensis-gen-nov-sp-nov-from-shallow-water-wood-falls
#6
https://www.readbyqxmd.com/read/27906975/bringing-plos-genetics-editors-to-preprint-servers
#7
EDITORIAL
Gregory S Barsh, Casey M Bergman, Christopher D Brown, Nadia D Singh, Gregory P Copenhaver
No abstract text is available yet for this article.
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27902769/correction-correlates-of-perceived-access-and-implications-for-health-system-strengthening-lessons-from-hiv-aids-treatment-and-care-services-in-ethiopia
#8
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0161553.].
2016: PloS One
https://www.readbyqxmd.com/read/27902692/correction-multi-level-modeling-of-light-induced-stomatal-opening-offers-new-insights-into-its-regulation-by-drought
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pcbi.1003930.].
November 2016: PLoS Computational Biology
https://www.readbyqxmd.com/read/27898673/towards-equity-in-health-researchers-take-stock
#10
EDITORIAL
Annette Rid, Michael A Johansson, Gabriel Leung, Hannah Valantine, Esteban G Burchard, Sam S Oh, Cathy Zimmerman
For the 2016 end-of-the-year editorial, the PLOS Medicine editors asked 7 global health leaders to discuss developments relevant to the equitable provision of medical care to all populations. The result is a collection of expert views on ethical trial design, research during outbreaks, high-burden infectious diseases, diversity in research and protection of migrants.
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27893753/correction-rare-functional-variant-in-tm2d3-is-associated-with-late-onset-alzheimer-s-disease
#11
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pgen.1006327.].
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27890529/mass-spectrometry-analysis-shows-the-biosynthetic-pathways-supported-by-pyruvate-carboxylase-in-highly-invasive-breast-cancer-cells
#12
Phatchariya Phannasil, Israr-Ul H Ansari, Mahmoud El Azzouny, Melissa J Longacre, Khanti Rattanapornsompong, Charles F Burant, Sarawut Jitrapakdee, Michael J MacDonald
We recently showed that the anaplerotic enzyme pyruvate carboxylase (PC) is up-regulated in human breast cancer tissue and its expression is correlated with the late stages of breast cancer and tumor size [Phannasil et al., PloS One 10, e0129848, 2015]. In the current study we showed that PC enzyme activity is much higher in the highly invasive breast cancer cell line MDA-MB-231 than in less invasive breast cancer cell lines. We generated multiple stable PC knockdown cell lines from the MDA-MB-231 cell line and used mass spectrometry with (13)C6-glucose and (13)C5-glutamine to discern the pathways that use PC in support of cell growth...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27880827/correction-e2f1-and-tfdp1-regulate-pitx1-expression-in-normal-and-osteoarthritic-articular-chondrocytes
#13
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0165951.].
2016: PloS One
https://www.readbyqxmd.com/read/27880771/differences-in-connection-strength-between-mental-symptoms-might-be-explained-by-differences-in-variance-reanalysis-of-network-data-did-not-confirm-staging
#14
Berend Terluin, Michiel R de Boer, Henrica C W de Vet
BACKGROUND: The network approach to psychopathology conceives mental disorders as sets of symptoms causally impacting on each other. The strengths of the connections between symptoms are key elements in the description of those symptom networks. Typically, the connections are analysed as linear associations (i.e., correlations or regression coefficients). However, there is insufficient awareness of the fact that differences in variance may account for differences in connection strength...
2016: PloS One
https://www.readbyqxmd.com/read/27874987/retraction
#15
(no author information available yet)
This article corrects: Retracted: Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis. New Phytologist 205: 202-215. Article first published online: 29 September 2014. This article has been retracted at the request of: Editor-in-Chief and Author 'Three BUB1 and BUBR1/MAD3-related spindle assembly checkpoint proteins are required for accurate mitosis in Arabidopsis', by Paganelli L, Caillaud M-C, Quentin M, Damiani I, Govetto B, Lecomte P, Karpov, PA, Abad P, Chabouté M-E and Favery B...
December 2016: New Phytologist
https://www.readbyqxmd.com/read/27861584/correction-ibmpfd-disease-causing-mutant-vcp-p97-proteins-are-targets-of-autophagic-lysosomal-degradation
#16
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0164864.].
2016: PloS One
https://www.readbyqxmd.com/read/27855204/retraction-genome-wide-analysis-of-the-dof-transcription-factor-gene-family-reveals-soybean-specific-duplicable-and-functional-characteristics
#17
https://www.readbyqxmd.com/read/27855102/non-inferiority-trials-are-they-inferior-a-systematic-review-of-reporting-in-major-medical-journals
#18
Sunita Rehal, Tim P Morris, Katherine Fielding, James R Carpenter, Patrick P J Phillips
OBJECTIVE: To assess the adequacy of reporting of non-inferiority trials alongside the consistency and utility of current recommended analyses and guidelines. DESIGN: Review of randomised clinical trials that used a non-inferiority design published between January 2010 and May 2015 in medical journals that had an impact factor >10 (JAMA Internal Medicine, Archives Internal Medicine, PLOS Medicine, Annals of Internal Medicine, BMJ, JAMA, Lancet and New England Journal of Medicine)...
October 7, 2016: BMJ Open
https://www.readbyqxmd.com/read/27849389/core-stability-exercise-versus-general-exercise-for-chronic-low-back-pain
#19
Brian J Coulombe, Kenneth E Games, Elizabeth R Neil, Lindsey E Eberman
: Reference: Wang XQ, Zheng JJ, Yu ZW, et al. A meta-analysis of core stability exercise versus general exercise for chronic low back pain. PLoS One. 2012;7(12):e52082. Clinical Questions: Is core stability exercise more effective than general exercise in the treatment of patients with nonspecific low back pain (LBP)? DATA SOURCES: The authors searched the following databases: China Biological Medicine disc, Cochrane Library, Embase, and PubMed from 1970 through 2011...
November 16, 2016: Journal of Athletic Training
https://www.readbyqxmd.com/read/27848113/calcium-waves-in-a-grid-of-clustered-channels-with-synchronous-ip3-binding-and-unbinding
#20
M Rückl, S Rüdiger
Calcium signals in cells occur at multiple spatial scales and variable temporal duration. However, a physical explanation for transitions between long-lasting global oscillations and localized short-term elevations (puffs) of cytoplasmic Ca(2+) is still lacking. Here we introduce a phenomenological, coarse-grained model for the calcium variable, which is represented by ordinary differential equations. Due to its small number of parameters, and its simplicity, this model allows us to numerically study the interplay of multi-scale calcium concentrations with stochastic ion channel gating dynamics even in larger systems...
November 2016: European Physical Journal. E, Soft Matter
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