Xiao-Jing Lin, Shaonan Wen, Ling-Xiao Deng, Heqiao Dai, Xiaolong Du, Chen Chen, Melissa J Walker, Ting-Bao Zhao, Xiao-Ming Xu
Incomplete spinal cord injury (SCI) often leads to impairments of sensorimotor functions and is clinically the most frequent type of SCI. Human Brown-Séquard syndrome is a common type of incomplete SCI caused by a lesion to one half of the spinal cord which results in paralysis and loss of proprioception on the same (or ipsilesional) side as the injury, and loss of pain and temperature sensation on the opposite (or contralesional) side. Adequate methodologies for producing a spinal cord lateral hemisection (HX) and assessing neurological impairments are essential to establish a reliable animal model of Brown-Séquard syndrome...
March 24, 2020: Journal of Visualized Experiments: JoVE