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https://www.readbyqxmd.com/read/28102972/evaluating-the-clinical-copd-questionnaire-a-systematic-review
#1
REVIEW
Zijing Zhou, Aiyuan Zhou, Yiyang Zhao, Ping Chen
The Clinical COPD Questionnaire (CCQ) is recommended by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) to evaluate health status in patients with COPD. The objective of this work was to systemically assess the reliability, validity, responsiveness and minimum clinically important difference (MCID) of the CCQ. A structured search was conducted in three databases to identify articles that evaluated the psychometric properties of the CCQ in individuals with COPD. Two investigators screened the title, abstract and full text of the articles to determine study eligibility and performed the data extraction...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28097181/social-well-being-and-related-factors-in-students-of-school-of-nursing-and-midwifery
#2
Alireza Salehi, Maryam Marzban, Maryam Sourosh, Farkhondeh Sharif, Mahmoud Nejabat, Mohammad Hadi Imanieh
BACKGROUND: According to the World Health Organization viewpoint, social well-being is an important dimension of health along with physical and mental aspects. Evaluation of social well-being is necessary in students, especially in medical sciences students due to future responsibility as health care professionals. The present study attempted to investigate the level of social well-being, five domains of it (like actualization, integration, contribution), and some related factors in the school of nursing and midwifery students...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28093590/hydrogen-diffusion-into-the-subsurfaces-of-model-metal-catalysts-from-first-principles
#3
Xiangjian Shen, Yuanjie Li, Xianglin Liu, Dandan Zhang, Jian Gao, Tianshui Liang
Diffusion pathways of atomic hydrogen on model catalyst surfaces and into subsurfaces are of great significance in the exploration of novel catalytic hydrogenation in heterogeneous catalysis. We present in detail the diffusion pathways of hydrogen on seven different open and closed model catalyst surfaces from first principles calculations. Seven transition metal catalysts with thirteen different crystal surfaces, i.e., Co(001), Ni(100) and Ni(111), Pd(100) and (111), Pt(100) and (111), Cu(100) and (111), Ag(100) and (111) and Au(100) and (111), are taken into account...
January 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28091803/a-study-of-hyperelastic-models-for-predicting-the-mechanical-behavior-of-extensor-apparatus
#4
Nahid Elyasi, Kimia Karimi Taheri, Keivan Narooei, Ali Karimi Taheri
In this research, the nonlinear elastic behavior of human extensor apparatus was investigated. To this goal, firstly the best material parameters of hyperelastic strain energy density functions consisting of the Mooney-Rivlin, Ogden, invariants, and general exponential models were derived for the simple tension experimental data. Due to the significance of stress response in other deformation modes of nonlinear models, the calculated parameters were used to study the pure shear and balance biaxial tension behavior of the extensor apparatus...
January 16, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28088915/evaluation-of-microrna-stability-in-plasma-and-serum-from-healthy-dogs
#5
Lars Enelund, Lise Nikolic Nielsen, Susanna Cirera
BACKGROUND: Early and specific detection of cancer is of great importance for successful treatment of the disease. New biomarkers, like microRNAs, could improve treatment efficiency and survival ratio. In human medicine, deregulation of microRNA profiles in circulation has shown great potential as a new type of biomarker for cancer diagnostics. There are, however, few studies of circulating microRNAs in dogs. Extracellular circulating microRNAs have shown a high level of stability in human blood and other body fluids...
January 13, 2017: MicroRNA
https://www.readbyqxmd.com/read/28077047/extended-infusion-compared-to-standard-infusion-cefepime-as-empiric-treatment-of-febrile-neutropenia
#6
Rebekah H Wrenn, David Cluck, LeAnne Kennedy, Christopher Ohl, John C Williamson
Background Extended infusion (EI) dosing provides a longer time above the minimum inhibitory concentration, which is important for the clinical success of β-lactam antibiotics, especially for patients with impaired immunity. The aim of this study was to determine the feasibility and clinical impact of administering cefepime by EI as treatment of febrile neutropenia. Methods This was a prospective, randomized, comparative pilot study. All patients received cefepime 2 g IV every 8 h, with the first dose administered using a 30-min infusion...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28076926/yoga-treatment-for-chronic-non-specific-low-back-pain
#7
REVIEW
L Susan Wieland, Nicole Skoetz, Karen Pilkington, Ramaprabhu Vempati, Christopher R D'Adamo, Brian M Berman
BACKGROUND: Non-specific low back pain is a common, potentially disabling condition usually treated with self-care and non-prescription medication. For chronic low back pain, current guidelines state that exercise therapy may be beneficial. Yoga is a mind-body exercise sometimes used for non-specific low back pain. OBJECTIVES: To assess the effects of yoga for treating chronic non-specific low back pain, compared to no specific treatment, a minimal intervention (e...
January 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28076679/molecular-dynamics-simulations-for-deciphering-structural-basis-of-recognition-of-pre-let-7-mirnas-by-lin28
#8
Chhaya Sharma, Debasisa Mohanty
LIN28 protein inhibits biogenesis of miRNAs belonging to let-7 family by binding to precursor forms of miRNAs. Over expression of LIN28 and low levels of let-7 miRNAs are associated with several forms of cancer cells. We have performed multiple explicit solvent molecular dynamics simulations ranging from 200 to 500 ns in length on different isoforms of preE-let7 in complex with LIN28 and also in isolation to identify structural features and key specificity determining residues (SDR) important for inhibitory role of LIN28...
January 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28073537/role-of-resting-cysts-in-chilean-alexandrium-catenella-dinoflagellate-blooms-revisited
#9
Jorge I Mardones, Chris Bolch, Leonardo Guzmán, Javier Paredes, Daniel Varela, Gustaaf M Hallegraeff
The detection of sparse Alexandrium catenella-resting cysts in sediments of southern Chilean fjords has cast doubts on their importance in the recurrence of massive toxic dinoflagellate blooms in the region. The role of resting cysts and the existence of different regional Chilean populations was studied by culturing and genetic approaches to define: (1) cyst production; (2) dormancy period; (3) excystment success; (4) offspring viability and (5) strain mating compatibility. This study newly revealed a short cyst dormancy (minimum 69 days), the role of key abiotic factors (in decreasing order salinity, irradiance, temperature and nutrients) controlling cyst germination (max...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28070268/a-systematic-review-of-thrust-manipulation-for-non-surgical-shoulder-conditions
#10
REVIEW
Amy L Minkalis, Robert D Vining, Cynthia R Long, Cheryl Hawk, Katie de Luca
PURPOSE: Although many conservative management options are available for patients with non-surgical shoulder conditions, there is little evidence of their effectiveness. This review investigated one manual therapy approach, thrust manipulation, as a treatment option. METHODS: A systematic search was conducted of the electronic databases from inception to March 2016: PubMed, PEDro, ICL, CINAHL, and AMED. Two independent reviewers conducted the screening process to determine article eligibility...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28068966/glenoid-morphology-in-light-of-anatomical-and-reverse-total-shoulder-arthroplasty-a-dissection-and-3d-ct-based-study-in-male-and-female-body-donors
#11
Sandra Mathews, Marco Burkhard, Nabil Serrano, Karl Link, Martin Häusler, Nakita Frater, Ingeborg Franke, Helena Bischofberger, Florian M Buck, Dominic Gascho, Michael Thali, Steffen Serowy, Magdalena Müller-Gerbl, Gareth Harper, Ford Qureshi, Thomas Böni, Hans-Rudolf Bloch, Oliver Ullrich, Frank-Jakobus Rühli, Elisabeth Eppler
BACKGROUND: Placement of the glenoid baseplate is of paramount importance for the outcome of anatomical and reverse total shoulder arthroplasty. However, the database around glenoid size is poor, particularly regarding small scapulae, for example, in women and smaller individuals, and is derived from different methodological approaches. In this multimodality cadaver study, we systematically examined the glenoid using morphological and 3D-CT measurements. METHODS: Measurements of the glenoid and drill hole tunnel length for superior baseplate screw placement were recorded to define size of the glenoid and the distance to the scapular notch on cadaveric specimens...
January 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28066967/artepillin-c-and-phenolic-compounds-responsible-for-antimicrobial-and-antioxidant-activity-of-green-propolis-and-baccharis-dracunculifolia-dc
#12
R S Veiga, S Mendonça, P B Mendes, N Paulino, M J Mimica, A A Lagareiro Netto, I S Lira, B G C López, V Negrão, M C Marcucci
AIMS: This study investigates the antimicrobial activity in Staphylococcus aureus isolates (MSSA - Methicillin Sensitive Staphylococcus aureus and MRSA - Methicillin Resistant Staphylococcus aureus) and antioxidant activity of green propolis, Baccharis dracunculifolia DC extracts and Artepillin C(™) . METHODS AND RESULTS: The amount of Artepillin C in different extracts was determined by HPLC analysis. Minimum Inhibitory Concentrations 90 (MIC90) was determined using 40 isolates of Staphylococcus aureus inoculated in Müeller-Hinton agar culture medium containing the green-propolis and Baccharis dracunculifolia DC extracts...
January 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28065899/statistical-inference-of-protein-structural-alignments-using-information-and-compression
#13
James H Collier, Lloyd Allison, Arthur M Lesk, Peter J Stuckey, Maria Garcia de la Banda, Arun S Konagurthu
MOTIVATION: Structural molecular biology depends crucially on computational techniques that compare protein three-dimensional structures and generate structural alignments (the assignment of one-to-one correspondences between subsets of amino acids based on atomic coordinates). Despite its importance, the structural alignment problem has not been formulated, much less solved, in a consistent and reliable way. To overcome these difficulties, we present here a statistical framework for the precise inference of structural alignments, built on the Bayesian and information-theoretic principle of Minimum Message Length (MML)...
January 8, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28063763/low-pretreatment-lymphocyte-monocyte-ratio-and-high-platelet-lymphocyte-ratio-indicate-poor-cancer-outcome-in-early-tongue-cancer
#14
Hui Shan Ong, Sandhya Gokavarapu, Li Zhen Wang, Zhen Tian, Chen Ping Zhang
PURPOSE: The white blood cell (WBC) indices have been reported to have a prognostic impact in cancer of multiple organs including head and neck cancer; however; site and stage stratification was not attempted, and compelling evidence has shown that early cancers have a different distribution and prognostication than late-stage cancers. We studied the prognostic importance of WBC indices in early oral tongue cancers. PATIENTS AND METHODS: The retrospective data of primary pT1N0 to pT2N0 oral tongue cancers treated between 2009 and 2013 were charted...
December 26, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28059391/sparse-identification-for-nonlinear-optical-communication-systems-sino-method
#15
Mariia Sorokina, Stylianos Sygletos, Sergei Turitsyn
We introduce low complexity machine learning method method (based on lasso regression, which promotes sparsity, to identify the interaction between symbols in different time slots and to select the minimum number relevant perturbation terms that are employed) for nonlinearity mitigation. The immense intricacy of the problem calls for the development of "smart" methodology, simplifying the analysis without losing the key features that are important for recovery of transmitted data. The proposed sparse identification method for optical systems (SINO) allows to determine the minimal (optimal) number of degrees of freedom required for adaptive mitigation of detrimental nonlinear effects...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28054597/trade-offs-between-driving-nodes-and-time-to-control-in-complex-networks
#16
Sérgio Pequito, Victor M Preciado, Albert-László Barabási, George J Pappas
Recent advances in control theory provide us with efficient tools to determine the minimum number of driving (or driven) nodes to steer a complex network towards a desired state. Furthermore, we often need to do it within a given time window, so it is of practical importance to understand the trade-offs between the minimum number of driving/driven nodes and the minimum time required to reach a desired state. Therefore, we introduce the notion of actuation spectrum to capture such trade-offs, which we used to find that in many complex networks only a small fraction of driving (or driven) nodes is required to steer the network to a desired state within a relatively small time window...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28054462/optimization-of-biopharmaceutical-downstream-processes-supported-by-mechanistic-models-and-artificial-neural-networks
#17
Silvia M Pirrung, Luuk A M van der Wielen, Ruud F W C Van Beckhoven, Emile J A X van de Sandt, Michel H M Eppink, Marcel Ottens
Downstream process development is a major area of importance within the field of bioengineering. During the design of such a downstream process, important decisions have to be made regarding the type of unit operations as well as their sequence and their operating conditions. Current computational approaches addressing these issues either show a high level of simplification or struggle with computational speed. Therefore, this article presents a new approach that combines detailed mechanistic models and speed-enhancing artificial neural networks...
January 5, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28053782/dexamethasone-abrogates-the-antimicrobial-and-antibiofilm-activities-of-different-drugs-against-clinical-isolates-of-staphylococcus-aureus-and-pseudomonas-aeruginosa
#18
Aquila Rodrigues, André Gomes, Pedro Henrique Ferreira Marçal, Marcus Vinícius Dias-Souza
Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding sequelae. Although different pharmaceutical dosage forms of antimicrobials combined to corticosteroids are available, studies on the interference of corticosteroids on the pharmacological activity of antimicrobials are scarce and controversial...
January 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28050812/statistics-in-brief-minimum-clinically-important-difference-availability-of-reliable-estimates
#19
Mitchell Maltenfort, Claudio Díaz-Ledezma
No abstract text is available yet for this article.
January 3, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28049424/a-mixed-integer-linear-programming-approach-to-the-reduction-of-genome-scale-metabolic-networks
#20
Annika Röhl, Alexander Bockmayr
BACKGROUND: Constraint-based analysis has become a widely used method to study metabolic networks. While some of the associated algorithms can be applied to genome-scale network reconstructions with several thousands of reactions, others are limited to small or medium-sized models. In 2015, Erdrich et al. introduced a method called NetworkReducer, which reduces large metabolic networks to smaller subnetworks, while preserving a set of biological requirements that can be specified by the user...
January 3, 2017: BMC Bioinformatics
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