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https://www.readbyqxmd.com/read/28727937/preoperative-short-form-health-survey-score-is-predictive-of-return-to-play-and-minimal-clinically-important-difference-at-a-minimum-2-year-follow-up-after-anterior-cruciate-ligament-reconstruction
#1
Benedict U Nwachukwu, Brenda Chang, Pramod B Voleti, Patricia Berkanish, Matthew R Cohn, David W Altchek, Answorth A Allen, Riley J Williams
BACKGROUND: There is increased interest in understanding the preoperative determinants of postoperative outcomes. Return to play (RTP) and the patient-reported minimal clinically important difference (MCID) are useful measures of postoperative outcomes after anterior cruciate ligament reconstruction (ACLR). PURPOSE: To define the MCID after ACLR and to investigate the role of preoperative outcome scores for predicting the MCID and RTP after ACLR. STUDY DESIGN: Case-control study; Level of evidence, 3...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28727025/effect-of-handling-intensity-at-the-time-of-transport-for-slaughter-on-physiological-response-and-carcass-characteristics-in-beef-cattle-fed-ractopamine-hydrochloride
#2
J A Hagenmaier, C D Reinhardt, S J Bartle, J N Henningson, M J Ritter, M S Calvo-Lorenzo, G J Vogel, C A Guthrie, M G Siemens, D U Thomson
The effects of handling intensity on the physiological response and carcass characteristics of feedlot cattle fed ractopamine hydrochloride were evaluated at the time of transport to slaughter. Eighty steers (BW = 668 ± 36 kg) representing 10 lots of similar breed, frame size, and degree of finish were blocked by lot, stratified by weight, and randomly assigned to 1 of 2 handling intensities (HI) over a 1,600 m dirt alley course: 1) low-stress handling (LSH) or 2) high-stress handling (HSH). For the LSH treatment, 4 penmates were kept at a walk with the use of a lead rider...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726181/ki-67-heterogeneity-in-well-differentiated-gastro-entero-pancreatic-neuroendocrine-tumors-when-is-biopsy-reliable-for-grade-assessment
#3
Grillo Federica, Valle Luca, Ferone Diego, Albertelli Manuela, Brisigotti Maria Pia, Cittadini Giuseppe, Vanoli Alessandro, Fiocca Roberto, Mastracci Luca
PURPOSE: Ki-67 heterogeneity can impact on gastroenteropancreatic neuroendocrine tumor grade assignment, especially when tissue is scarce. This work is aimed at devising adequacy criteria for grade assessment in biopsy specimens. METHOD: To analyze the impact of biopsy size on reliability, 360 virtual biopsies of different thickness and lengths were constructed. Furthermore, to estimate the mean amount of non-neoplastic tissue component present in biopsies, 28 real biopsies were collected, the non-neoplastic components (fibrosis and inflammation) quantified and the effective area of neoplastic tissue calculated for each biopsy...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28724993/prediction-of-presynaptic-and-postsynaptic-neurotoxins-by-combining-various-chou-s-pseudo-components
#4
Haiyan Huo, Tao Li, Shiyuan Wang, Yingli Lv, Yongchun Zuo, Lei Yang
Presynaptic and postsynaptic neurotoxins are two groups of neurotoxins. Identification of presynaptic and postsynaptic neurotoxins is an important work for numerous newly found toxins. It is both costly and time consuming to determine these two neurotoxins by experimental methods. As a complement, using computational methods for predicting presynaptic and postsynaptic neurotoxins could provide some useful information in a timely manner. In this study, we described four algorithms for predicting presynaptic and postsynaptic neurotoxins from sequence driven features by using Increment of Diversity (ID), Multinomial Naive Bayes Classifier (MNBC), Random Forest (RF), and K-nearest Neighbours Classifier (IBK)...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723228/thermal-processing-of-live-bivalve-molluscs-for-controlling-viruses-on-the-need-for-a-risk-based-design
#5
Winy Messens, Pablo S Fernandez-Escamez, David Lees, Roland Lindqvist, Michael O'Mahony, Elisabetta Suffredini, José Cortiñas Abrahantes, Emmanouil Chantzis, Kostas Koutsoumanis
Norovirus (NoV) and Hepatitis A virus (HAV) are the most important viral hazards associated with human illness following consumption of contaminated bivalve molluscs. The effectiveness of the current EU criteria for heat processing of bivalve molluscs (i.e. raising the temperature of the internal mollusc flesh to at least 90°C for a minimum of 90 seconds) was evaluated using predictive microbiology. A HAV thermal inactivation model was developed based on literature data in mollusc matrices during isothermal heat treatment...
July 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28717629/ultrasound-measures-of-tendon-thickness-intra-rater-inter-rater-and-inter-machine-reliability
#6
María Elena Del Baño-Aledo, Jacinto Javier Martínez-Payá, José Ríos-Díaz, Silvia Mejías-Suárez, Sergio Serrano-Carmona, Ana de Groot-Ferrando
BACKGROUND: Ultrasound imaging is often used by physiotherapists and other healthcare professionals but the reliability of image acquisition with different ultrasound machines is unknown. The objective was to compare the intra-rater, inter-rater and intermachine reliability of thickness measurements of the plantar fascia (PF), Achilles tendon (AT), patellar tendon (PT) and elbow common extensor tendon (ECET) with musculoskeletal ultrasound imaging (MSUS). METHODS: Tendon thickness was measured in four anatomical structures (14 participants, 28 images per tendon) by two sonographers and with two different ultrasound machines...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28716065/the-validity-of-the-sf-12-and-sf-6d-instruments-in-people-living-with-hiv-aids-in-kenya
#7
Anik R Patel, Richard T Lester, Carlo A Marra, Mia L van der Kop, Paul Ritvo, Lidia Engel, Sarah Karanja, Larry D Lynd
BACKGROUND: Health-related quality of life (HRQoL) and health state utility value (HSUV) measurements are vital components of healthcare clinical and economic evaluations. Accurate measurement of HSUV and HRQoL require validated instruments. The 12-item Short-Form Health Survey (SF-12) is one of few instruments that can evaluate both HRQoL and HSUV, but its validity has not been assessed in people living with HIV/AIDS (PLWHA) in east Africa, where the burden of HIV is high. METHODS: This cross-sectional study used baseline data from a randomized trial involving PLWHA in Kenya...
July 17, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28716028/antiplasmodial-potential-and-quantification-of-aloin-and-aloe-emodin-in-aloe-vera-collected-from-different-climatic-regions-of-india
#8
Sandeep Kumar, Manila Yadav, Amita Yadav, Pooja Rohilla, Jaya Parkash Yadav
BACKGROUND: In this study, Aloe vera samples were collected from different climatic regions of India. Quantitative HPTLC (high performance thin layer chromatography) analysis of important anthraquinones aloin and aloe-emodin and antiplasmodial activity of crude aqueous extracts was done to estimate the effects of these constituents on antiplasmodial potential of the plant. METHODS: HPTLC system equipped with a sample applicator Linomat V with CAMAG sample syringe, twin rough plate development chamber (20 x 10 cm), TLC Scanner 3 and integration software WINCATS 1...
July 17, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28714394/nanoparticle-mediated-delivery-of-neuroprotective-substances-for-the-treatment-of-diabetic-retinopathy
#9
Rosario Amato, Massimo Dal Monte, Matteo Lulli, Vittoria Raffa, Giovanni Casini
Diabetic retinopathy (DR) is a major complication of diabetes, characterized by extensive vascular pathology leading to vision loss. Neuronal suffering and death are also present in the diabetic retina as a result of different molecular mechanisms that are compromised or modified in response to high glucose and that mainly include excitotoxicity, advanced glycation, inflammation and oxidative stress. Recent data indicate that the vascular changes may be secondary to damage of retinal neurons and that neurodegeneration is likely to play a primary role in the development of DR...
July 17, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28713402/unmanned-aerial-vehicle-remote-sensing-for-field-based-crop-phenotyping-current-status-and-perspectives
#10
REVIEW
Guijun Yang, Jiangang Liu, Chunjiang Zhao, Zhenhong Li, Yanbo Huang, Haiyang Yu, Bo Xu, Xiaodong Yang, Dongmei Zhu, Xiaoyan Zhang, Ruyang Zhang, Haikuan Feng, Xiaoqing Zhao, Zhenhai Li, Heli Li, Hao Yang
Phenotyping plays an important role in crop science research; the accurate and rapid acquisition of phenotypic information of plants or cells in different environments is helpful for exploring the inheritance and expression patterns of the genome to determine the association of genomic and phenotypic information to increase the crop yield. Traditional methods for acquiring crop traits, such as plant height, leaf color, leaf area index (LAI), chlorophyll content, biomass and yield, rely on manual sampling, which is time-consuming and laborious...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712801/the-effect-of-pelvic-tilt-and-femoral-head-size-on-hip-range-of-motion-to-impingement
#11
Thomas F McCarthy, Jim Nevelos, Randa K Elmallah, Morad Chughtai, Anton Khlopas, Vincent Alipit, Timothy C Wagner, Michael A Mont
BACKGROUND: About 50%-70% of dislocators have cups placed within so-called "safe zones." It has been postulated that factors such as femoral head size and pelvic tilt, obliquity, or rotation may influence postoperative stability. Therefore, we assessed varying degrees of pelvic tilt and head sizes on the range of motion (ROM) to impingement. METHODS: A hip simulator was used to import models of 10 subjects who performed object pickup, squatting, and low-chair rising...
June 15, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28711423/randomized-trial-of-intelligent-sensor-system-for-early-illness-alerts-in-senior-housing
#12
Marilyn Rantz, Lorraine J Phillips, Colleen Galambos, Kari Lane, Gregory L Alexander, Laurel Despins, Richelle J Koopman, Marjorie Skubic, Lanis Hicks, Steven Miller, Andy Craver, Bradford H Harris, Chelsea B Deroche
OBJECTIVES: Measure the clinical effectiveness and cost effectiveness of using sensor data from an environmentally embedded sensor system for early illness recognition. This sensor system has demonstrated in pilot studies to detect changes in function and in chronic diseases or acute illnesses on average 10 days to 2 weeks before usual assessment methods or self-reports of illness. DESIGN: Prospective intervention study in 13 assisted living (AL) communities of 171 residents randomly assigned to intervention (n=86) or comparison group (n=85) receiving usual care...
July 12, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28711002/effect-of-temperature-on-sulfonamide-antibiotics-degradation-and-on-antibiotic-resistance-determinants-and-hosts-in-animal-manures
#13
Hui Lin, Jin Zhang, Hongjin Chen, Jianmei Wang, Wanchun Sun, Xin Zhang, Yuyi Yang, Qiang Wang, Junwei Ma
Animal manure is a main reservoir of antibiotic residues and antibiotic resistance. Here, the effect of temperature on sulfonamide antibiotics (SAs), sulfonamide-resistant (SR) genes/bacteria was investigated by aerobically incubating swine and chicken manures at different temperatures. In swine manure, the SAs concentration declined with increasing temperature, with a minimum at 60°C. In chicken manure, the greatest degradation of SAs was noted at 30°C. The reduction of relative abundance of antibiotic resistance genes (ARGs) and sul-positive hosts in swine manure was more pronounced during thermophilic than mesospheric incubation; neither temperature conditions effectively reduced these parameters in chicken manure...
July 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28709986/comparison-of-different-strategies-for-using-fossil-calibrations-to-generate-the-time-prior-in-bayesian-molecular-clock-dating
#14
Jose Barba-Montoya, Mario Dos Reis, Ziheng Yang
Fossil calibrations are the utmost source of information for resolving the distances between molecular sequences into estimates of absolute times and absolute rates in molecular clock dating analysis. The quality of calibrations is thus expected to have a major impact on divergence time estimates even if a huge amount of molecular data is available. In Bayesian molecular clock dating, fossil calibration information is incorporated in the analysis through the prior on divergence times (the time prior). Here, we evaluate three strategies for converting fossil calibrations (in the form of minimum- and maximum-age bounds) into the prior on times, which differ according to whether they borrow information from the maximum age of ancestral nodes and minimum age of descendent nodes to form constraints for any given node on the phylogeny...
July 11, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28709806/the-sugar-code-why-glycans-are-so-important
#15
REVIEW
Hans-Joachim Gabius
The cell surface is the platform for presentation of biochemical signals that are required for intercellular communication. Their profile necessarily needs to be responsive to internal and external factors in a highly dynamic manner. The structural features of the signals must meet the criterion of high-density information coding in a minimum of space. Thus, only biomolecules that can generate many different oligomers ('words') from few building blocks ('letters') qualify to meet this challenge. Examining the respective properties of common biocompounds that form natural oligo- and polymers comparatively, starting with nucleotides and amino acids (the first and second alphabets of life), comes up with sugars as clear frontrunner...
July 11, 2017: Bio Systems
https://www.readbyqxmd.com/read/28704063/evaluation-of-accuracy-of-six-blood-glucose-monitoring-systems-and-modeling-of-possibly-related-insulin-dosing-errors
#16
Annette Baumstark, Nina Jendrike, Stefan Pleus, Cornelia Haug, Guido Freckmann
OBJECTIVE: Self-monitoring of blood glucose (BG) is an essential part of diabetes therapy. Accurate and reliable results from BG monitoring systems (BGMS) are important especially when they are used to calculate insulin doses. This study aimed at assessing system accuracy of BGMS and possibly related insulin dosing errors. RESEARCH DESIGN AND METHODS: System accuracy of six different BGMS (Accu-Chek(®) Aviva Nano, Accu-Chek Mobile, Accu-Chek Performa Nano, CONTOUR(®) NEXT LINK 2...
July 13, 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28702747/management-of-supine-hypertension-complicating-neurogenic-orthostatic-hypotension
#17
Jacquie Baker, Kurt Kimpinski
Neurogenic orthostatic hypotension (NOH) can be present in a number of disorders, including synucleinopathies, autoimmune disorders, and various genetic disorders. All are characterized by defective norepinephrine release from sympathetic terminals upon standing, resulting in impaired vasoconstriction. NOH is defined as a drop in systolic blood pressure ≥20 mmHg or diastolic blood pressure ≥10 mmHg, or both, within 3 minutes of standing or head up-tilt at a minimum of 60°. However, approximately 50% of patients have associated supine hypertension, which greatly complicates treatment...
July 12, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28702086/transcriptome-and-key-genes-expression-related-to-carbon-fixation-pathways-in-chlorella-py-zu1-cells-and-their-growth-under-high-concentrations-of-co2
#18
Yun Huang, Jun Cheng, Hongxiang Lu, Yong He, Junhu Zhou, Kefa Cen
BACKGROUND: The biomass yield of Chlorella PY-ZU1 drastically increased when cultivated under high CO2 condition compared with that cultivated under air condition. However, less attention has been given to the microalgae photosynthetic mechanisms response to different CO2 concentrations. The genetic reasons for the higher growth rate, CO2 fixation rate, and photosynthetic efficiency of microalgal cells under higher CO2 concentration have not been clearly defined yet. RESULTS: In this study, the Illumina sequencing and de novo transcriptome assembly of Chlorella PY-ZU1 cells cultivated under 15% CO2 were performed and compared with those of cells grown under air...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28699964/antifungal-susceptibility-profile-of-diferent-yeasts-isolates-from-wild-animals-cow-s-milk-with-subclinical-mastitis-and-hospital-environment
#19
J F Mendes, C L Gonçalves, G F Ferreira, I A Esteves, C H Freitas, J P V Villarreal, J R B Mello, M C A Meireles, P S Nascente
Yeast infections have acquired great importance due to increasing frequency in immunocompromised patients or patients undergoing invasive diagnostic and therapeutic techniques, and also because of its high morbidity and mortality. At the same time, it has been seen an increase in the emergence of new pathogenic species difficult to diagnose and treat. The aim of this study was to determine the in vitro susceptibility of 89 yeasts from different sources against the antifungals amphotericin B, voriconazole, fluconazole and flucytosine, using the VITEK® 2 Compact system...
July 10, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28699595/effectiveness-of-non-steroidal-anti-inflammatory-drugs-for-the-treatment-of-pain-in-knee-and-hip-osteoarthritis-a-network-meta-analysis
#20
Bruno R da Costa, Stephan Reichenbach, Noah Keller, Linda Nartey, Simon Wandel, Peter Jüni, Sven Trelle
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are the backbone of osteoarthritis pain management. We aimed to assess the effectiveness of different preparations and doses of NSAIDs on osteoarthritis pain in a network meta-analysis. METHODS: For this network meta-analysis, we considered randomised trials comparing any of the following interventions: NSAIDs, paracetamol, or placebo, for the treatment of osteoarthritis pain. We searched the Cochrane Central Register of Controlled Trials (CENTRAL) and the reference lists of relevant articles for trials published between Jan 1, 1980, and Feb 24, 2015, with at least 100 patients per group...
July 8, 2017: Lancet
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