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https://www.readbyqxmd.com/read/28816730/intravitreal-injection-of-aflibercept-in-patients-with-polypoidal-choroidal-vasculopathy-a-3-year-follow-up
#1
Maiko Maruyama-Inoue, Shimpei Sato, Shin Yamane, Kazuaki Kadonosono
PURPOSE: To compare the 3-year follow-up results of intravitreal injections of aflibercept between fixed dosing (FD) regimen and a pro re nata (PRN) regimen after three initial monthly doses for the treatment of polypoidal choroidal vasculopathy and to analyze factors influencing improvement in visual acuity. METHODS: We retrospectively studied all treatment-naive patients with polypoidal choroidal vasculopathy who were scheduled to receive intravitreal aflibercept injections FD or PRN after induction treatment between March 2013 and May 2014...
August 14, 2017: Retina
https://www.readbyqxmd.com/read/28816149/a-multi-institution-retrospective-analysis-of-cervix-intracavitary-brachytherapy-treatments-part-1-is-eqd2-good-enough-for-reporting-radiobiological-effects
#2
Emma C Fields, Rakhi Melvani, George Hajdok, David D'Souza, Bernard Jones, Kelly Stuhr, Quentin Diot, Christine M Fisher, Nitai Mukhopadhyay, Dorin Todor
PURPOSE: When brachytherapy doses are reported or added, biologically effective dose (BED) minimum dose covering 90% of the volume (D90) is used as if dose is delivered uniformly to the target. Unlike BED(D90), equivalent uniform BED (EUBED) and generalized biologically equivalent uniform dose (gBEUD) are quantities that integrate dose inhomogeneity. Here we compared BED(D90) and equivalent uniform BED (EUBED)/gBEUD in 3 settings: (1) 2 sites using tandem and ovoid (T&O) but different styles of implants; (2) 2 sites using different devices-T&O and tandem and ring (T&R)-and different styles; and (3) the same site using T&O and T&R with the same style...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28809881/genetic-algorithm-optimized-wideband-on-chip-polarization-rotator-with-an-ultrasmall-footprint
#3
Zejie Yu, Haoran Cui, Xiankai Sun
Polarization control of light waves is an important technique in optical communication and signal processing. On-chip polarization rotation from the fundamental transverse-electric (TE00) mode to the fundamental transverse-magnetic (TM00) mode is usually difficult because of their large effective refractive index difference. Here, we demonstrate an on-chip wideband polarization rotator designed with a genetic algorithm to convert the TE00 mode into the TM00 mode within a footprint of 0.96 μm ×4.2  μm...
August 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28809666/biomolecular-network-controllability-with-drug-binding-information
#4
Lin Wu, Lingkai Tang, Min Li, Jianxin Wang, Fang-Xiang Wu
Complex networks are ubiquitous in nature. In biological systems, biomolecules interact with each other to form so-called biomolecular networks, which determine the cellular behaviors of living organisms. Controlling the cellular behaviors by regulating certain biomolecules in the network is one of the most concerned problems in systems biology. Recently, the connections between biological networks and structural control theory have been explored, uncovering some interesting biological phenomena. Some researchers have paid attentions to the structural controllability of networks in notion of the minimum steering sets (MSSs)...
July 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/28806624/bcl-2-bax-protein-and-mrna-expression-in-yak-bos-grunniens-placentomes
#5
JiangFeng Fan, SiJiu Yu, Yan Cui, Gengquan Xu, Libin Wang, Yangyang Pan, Honghong He
Placental function is complex and influenced by various factors; furthermore, it depends on a delicate balance between cell proliferation, cell differentiation, and cell death. Bcl-2 and Bax proteins are key apoptosis regulators and are considered to play an important role in the maintenance of both dynamic balance and integrity of many tissues. Changes in Bcl-2 and Bax expressions have been described during different developmental stages in normal human placentas. Studies furthermore indicated several pathological placental changes to be related to abnormal Bcl-2 and Bax expressions...
July 29, 2017: Theriogenology
https://www.readbyqxmd.com/read/28803652/long-term-follow-up-evaluation-of-autologous-chondrocyte-implantation-for-symptomatic-cartilage-lesions-of-the-knee-a-single-centre-prospective-study
#6
M Berruto, P Ferrua, S Pasqualotto, F Uboldi, A Maione, D Tradati, E Usellini
INTRODUCTION: Autologous Chondrocyte Implantation (ACI) has been the first technique in reconstruction of a valid articular surface. The aim of this study was to evaluate clinical results of this technique at an average follow up of 162±27months (range 88-208) in a group of patients who underwent ACI. MATERIALS AND METHODS: 32 patients were operated between 1997 and 2007 for chondral lesions or osteochondritis dissecans of the knee. Mean size of the defect was 5...
August 4, 2017: Injury
https://www.readbyqxmd.com/read/28802415/augmentation-of-intramedullary-nailing-in-unstable-intertrochanteric-fractures-using-cerclage-wire-and-lag-screws-a-comparative-study
#7
Sunil Govind Kulkarni, Sushrut Sudhir Babhulkar, Sujay Milind Kulkarni, Govind Shivram Kulkarni, Madhura Sujay Kulkarni, Raviraj Patil
BACKGROUND: Unstable intertrochanteric fractures present a challenge to orthopaedic surgeons, with varied geometry of the fractures and a wide choice of implants and techniques. The patients are usually osteoporotic, with multiple co-morbidities and poor tolerance for complications and re-operations. Lateral wall reconstruction and stability of the trochanteric fragments are considered important in providing a better outcome of these difficult injuries. We present a technique of lateral wall and trochanteric reconstruction using Cerclage wires and lag screws in the greater trochanter in addition to intramedullary nailing, and the radiological and functional outcome of this technique of augmentation...
August 2017: Injury
https://www.readbyqxmd.com/read/28801246/time-optimal-control-strategies-in-sir-epidemic-models
#8
Luca Bolzoni, Elena Bonacini, Cinzia Soresina, Maria Groppi
We investigate the time-optimal control problem in SIR (Susceptible-Infected-Recovered) epidemic models, focusing on different control policies: vaccination, isolation, culling, and reduction of transmission. Applying the Pontryagins Minimum Principle (PMP) to the unconstrained control problems (i.e. without costs of control or resource limitations), we prove that, for all the policies investigated, only bang-bang controls with at most one switch are admitted. When a switch occurs, the optimal strategy is to delay the control action some amount of time and then apply the control at the maximum rate for the remainder of the outbreak...
August 8, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28801228/identification-of-the-first-cathelicidin-gene-from-skin-of-chinese-giant-salamanders-andrias-davidianus-with-its-potent-antimicrobial-activity
#9
Hui Yang, Baoyue Lu, Dandan Zhou, Lin Zhao, Weijia Song, Lixin Wang
Cathelicidins, as effector molecules, play important roles against infections and represent a crucial component of the innate immune system in vertebrates. They are widely studied in mammals, but little is known in amphibians. In the present study, we report the identification and characterization of a novel cathelicidin from Chinese giant salamander Andrias davidianus, which is the first study in Caudata amphibian. The cDNA sequence encodes a predicted 148-amino-acid polypeptide, which composed of a 20-residue signal peptide, a 94-residue conserved cathelin domain and a 34-residue mature peptide...
August 9, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28800457/fucosylated-chondroitin-sulfate-oligosaccharides-exert-anticoagulant-activity-by-targeting-at-intrinsic-tenase-complex-with-low-fxii-activation-importance-of-sulfation-pattern-and-molecular-size
#10
Junhui Li, Shan Li, Lufeng Yan, Tian Ding, Robert J Linhardt, Yanlei Yu, Xinyue Liu, Donghong Liu, Xingqian Ye, Shiguo Chen
Fucosylated chondroitin sulfates (fCSs) are structurally unusual glycosaminoglycans isolated from sea cucumbers that exhibit potent anticoagulant activity. These fCSs were isolated from sea cucumber, Isostichopus badionotus and Pearsonothuria graeffei. Fenton reaction followed by gel filtration chromatography afforded fCS oligosaccharides, with different sulfation patterns identified by mass and NMR spectroscopy, and these were used to clarify the relationship between the structures and the anticoagulant activities of fCSs...
July 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28800273/assessing-the-impact-of-a-remote-digital-coaching-engagement-program-on-patient-reported-outcomes-in-asthma
#11
Mazi Rasulnia, Billy Stephen Burton, Robert P Ginter, Tracy Y Wang, Roy Alton Pleasants, Cynthia L Green, Njira Lugogo
BACKGROUND: Low adherence and poor outcomes provide opportunity for digital coaching to engage patients with uncontrolled asthma in their care to improve outcomes. OBJECTIVES: To examine the impact of a remote digital coaching program on asthma control and patient experience. METHODS: We recruited 51 adults with uncontrolled asthma, denoted by albuterol use of > 2 times per week and/or exacerbations requiring corticosteroids, and applied a 12-week patient-centered remote digital coaching program using a combination of educational pamphlets, symptom trackers, best peak flow establishment, physical activity, and dietary counseling, as well as coaches who implemented emotional enforcement  to motivate disease self-management through telephone, text, and email...
August 11, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28799837/effectiveness-of-deformity-correction-surgery-for-primary-degenerative-sagittal-imbalance-a-meta-analysis
#12
Chang-Hyun Lee, Chun Kee Chung, Jee-Soo Jang, Sung-Min Kim, Dong-Kyu Chin, Jung-Kil Lee, Seung Hwan Yoon, Jae Taek Hong, Yoon Ha, Chi Heon Kim, Seung-Jae Hyun
OBJECTIVE As life expectancy continues to increase, primary degenerative sagittal imbalance (PDSI) is diagnosed in an increasing number of elderly people. Although corrective surgery for this sagittal deformity is becoming more popular, the effectiveness of the procedure remains unclear. The authors aimed to collate the available evidence on the effectiveness and complications of deformity-correction surgery in patients with PDSI. METHODS The authors carried out a meta-analysis of clinical studies regarding deformity correction in patients with PDSI...
August 11, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28799338/negative-ion-photoelectron-spectra-of-iso3-is2o3-and-is2o4-intermediates-formed-in-interfacial-reactions-of-ozone-and-iodide-sulfite-aqueous-microdroplets
#13
Zhengbo Qin, Gao-Lei Hou, Zheng Yang, Marat Valiev, Xue-Bin Wang
Three short-lived, anionic intermediates, ISO3(-), IS2O3(-), and IS2O4(-), are detected during reactions between ozone and aqueous iodine/sulfur oxide microdroplets. These species may play an important role in ozone-driven inorganic aerosol formation; however their chemical properties remain largely unknown. This is the issue addressed in this work using negative ion photoelectron spectroscopy (NIPES) and ab initio modeling. The NIPE spectra reveal that all of the three anionic species are characterized by high adiabatic detachment energies (ADEs) - 4...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28799193/an-analysis-of-the-effects-of-intrapartum-factors-neonatal-characteristics-and-skin-to-skin-contact-on-early-breastfeeding-initiation
#14
Ying Lau, Pyai Htun Tha, Sarah Su Tin Ho-Lim, Lai Ying Wong, Peng Im Lim, Binte Zaini Mattar Citra Nurfarah, Shefaly Shorey
This study aims to determine relationships between intrapartum factors, neonatal characteristics, skin-to-skin contact (SSC), and early breastfeeding initiation after spontaneous vaginal and Caesarean section or operative vaginal birth. A total of 915 mother-newborn dyads were considered in a hypothetical model based on integrated concepts of breastfeeding initiation model, infant learning framework, and attachment theory. Multiple-group path analysis was used to determine whether differences exist between effects of immediate SSC (≤30 min) on early breastfeeding initiation in different modes of birth...
August 10, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28798757/establishing-the-bases-for-introducing-the-unexplored-portuguese-common-bean-germplasm-into-the-breeding-world
#15
Susana T Leitão, Marco Dinis, Maria M Veloso, Zlatko Šatović, Maria C Vaz Patto
Common bean (Phaseolus vulgaris L.) is among the most important grain legumes for human consumption worldwide. Portugal has a potentially promising common bean germplasm, resulting from more than five centuries of natural adaptation and farmers' selection. Nevertheless, limited characterization of this resource hampers its exploitation by breeding programs. To support a more efficient conservation of the national bean germplasm and promote its use in crop improvement, we performed, for the first time, a simultaneous molecular marker (21 microsatellites and a DNA marker for phaseolin-type diversity analysis) and seed and plant morphological characterization (14 traits) of 175 accessions from Portuguese mainland and islands traditional bean-growing regions...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28795369/trace-element-and-heavy-metal-levels-in-colorectal-cancer-comparison-between-cancerous-and-non-cancerous-tissues
#16
Masoudreza Sohrabi, Ali Gholami, MohammadHossein Hosseini Azar, Mohammad Yaghoobi, Maryamosadat Mirasgari Shahi, Solmaz Shirmardi, Mehdi Nikkhah, Zahra Kohi, Delaram Salehpour, Mahmood Reza Khoonsari, Gholamrez Hemmasi, Farhad Zamani, Mahmoudreza Sohrabi, Hossein Ajdarkosh
Cases of colorectal cancer (CRC) have increased dramatically in Middle Eastern and other Asian countries. Many studies indicate an important role of environmental factors, including trace elements as an etiology of cancer. This study aims to assess the concentration of eight trace elements in cancerous and adjacent non-cancerous tissues in case of CRC. In a cross-sectional study, conducted between March 2015 and February 2016, zinc (Zn), chromium (Cr), manganese (Mn), tin (Sn), copper (Cu), aluminum (Al), lead (Pb), and iron (Fe) levels were evaluated among patients suffering from CRC...
August 9, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28791144/machine-learning-landscapes-and-predictions-for-patient-outcomes
#17
Ritankar Das, David J Wales
The theory and computational tools developed to interpret and explore energy landscapes in molecular science are applied to the landscapes defined by local minima for neural networks. These machine learning landscapes correspond to fits of training data, where the inputs are vital signs and laboratory measurements for a database of patients, and the objective is to predict a clinical outcome. In this contribution, we test the predictions obtained by fitting to single measurements, and then to combinations of between 2 and 10 different patient medical data items...
July 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28791035/development-of-a-traceability-system-based-on-a-snp-array-for-large-scale-production-of-high-value-white-spruce-picea-glauca
#18
Julie Godbout, Laurence Tremblay, Caroline Levasseur, Patricia Lavigne, André Rainville, John Mackay, Jean Bousquet, Nathalie Isabel
Biological material is at the forefront of research programs, as well as application fields such as breeding, aquaculture, and reforestation. While sophisticated techniques are used to produce this material, all too often, there is no strict monitoring during the "production" process to ensure that the specific varieties are the expected ones. Confidence rather than evidence is often applied when the time comes to start a new experiment or to deploy selected varieties in the field. During the last decade, genomics research has led to the development of important resources, which have created opportunities for easily developing tools to assess the conformity of the material along the production chains...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28779963/partial-breast-radiotherapy-after-breast-conservation-surgery-for-patients-with-early-breast-cancer-uk-import-low-trial-5-year-results-from-a-multicentre-randomised-controlled-phase-3-non-inferiority-trial
#19
Charlotte E Coles, Clare L Griffin, Anna M Kirby, Jenny Titley, Rajiv K Agrawal, Abdulla Alhasso, Indrani S Bhattacharya, Adrian M Brunt, Laura Ciurlionis, Charlie Chan, Ellen M Donovan, Marie A Emson, Adrian N Harnett, Joanne S Haviland, Penelope Hopwood, Monica L Jefford, Ronald Kaggwa, Elinor J Sawyer, Isabel Syndikus, Yat M Tsang, Duncan A Wheatley, Maggie Wilcox, John R Yarnold, Judith M Bliss
BACKGROUND: Local cancer relapse risk after breast conservation surgery followed by radiotherapy has fallen sharply in many countries, and is influenced by patient age and clinicopathological factors. We hypothesise that partial-breast radiotherapy restricted to the vicinity of the original tumour in women at lower than average risk of local relapse will improve the balance of beneficial versus adverse effects compared with whole-breast radiotherapy. METHODS: IMPORT LOW is a multicentre, randomised, controlled, phase 3, non-inferiority trial done in 30 radiotherapy centres in the UK...
August 2, 2017: Lancet
https://www.readbyqxmd.com/read/28777302/bee-hymenoptera-apoidea-diversity-and-sampling-methodology-in-a-midwestern-usa-deciduous-forest
#20
Kenneth W McCravy, Jared D Ruholl
Forests provide potentially important bee habitat, but little research has been done on forest bee diversity and the relative effectiveness of bee sampling methods in this environment. Bee diversity and sampling methodology were studied in an Illinois, USA upland oak-hickory forest using elevated and ground-level pan traps, malaise traps, and vane traps. 854 bees and 55 bee species were collected. Elevated pan traps collected the greatest number of bees (473), but ground-level pan traps collected greater species diversity (based on Simpson's diversity index) than did elevated pan traps...
August 4, 2017: Insects
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