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https://www.readbyqxmd.com/read/29347207/role-of-anchoring-energy-on-the-texture-of-cholesteric-droplets-finite-element-simulations-and-experiments
#1
Guilhem Poy, Felix Bunel, Patrick Oswald
We present a numerical method to compute defect-free textures inside cholesteric domains of arbitrary shape. This method has two interesting properties, namely a robust and fast quadratic convergence to a local minimum of the Frank free energy, thanks to a trust region strategy. We apply this algorithm to study the texture of cholesteric droplets in coexistence with their isotropic liquid in two cases: when the anchoring is planar and when it is tilted. In the first case, we show how to determine the anchoring energy at the cholesteric-isotropic interface from a study of the optical properties of droplets of different sizes oriented with an electric field...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29339306/morphological-changes-of-bacterial-cells-upon-exposure-of-silver-silver-chloride-nanoparticles-synthesized-using-agrimonia-pilosa
#2
Maheshkumar Prakash Patil, Yong Bae Seo, Gun-Do Kim
Facile, eco-friendly synthesis of metal nanoparticles has been proposed as a cost effective method. In the present study, we propose the facile synthesis of silver-silver chloride (Ag-AgCl) nanoparticles (NPs) using the medicinally important Agrimonia pilosa plant extract without addition of capping or stabilizing agents. The Ag-AgCl NPs synthesis was observed at 40 °C after 10 min incubation; the synthesis of Ag-AgCl NPs was indicated by color change and confirmed by UV-vis spectroscopic peak at 454 nm...
January 12, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29334889/protein-protein-interface-hot-spots-prediction-based-on-a-hybrid-feature-selection-strategy
#3
Yanhua Qiao, Yi Xiong, Hongyun Gao, Xiaolei Zhu, Peng Chen
BACKGROUND: Hot spots are interface residues that contribute most binding affinity to protein-protein interaction. A compact and relevant feature subset is important for building machine learning methods to predict hot spots on protein-protein interfaces. Although different methods have been used to detect the relevant feature subset from a variety of features related to interface residues, it is still a challenge to detect the optimal feature subset for building the final model. RESULTS: In this study, three different feature selection methods were compared to propose a new hybrid feature selection strategy...
January 15, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29334392/control-of-collagen-gel-mechanical-properties-through-manipulation-of-gelation-conditions-near-the-sol-gel-transition
#4
A J Holder, N Badiei, K Hawkins, C Wright, P R Williams, D J Curtis
The ability to control the mechanical properties of cell culture environments is known to influence cell morphology, motility, invasion and differentiation. The present work shows that it is possible to control the mechanical properties of collagen gels by manipulating gelation conditions near the sol gel transition. This manipulation is accomplished by performing gelation in two stages at different temperatures. The mechanical properties of the gel are found to be strongly dependent on the duration and temperature of the first stage...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29330835/international-guidelines-for-groin-hernia-management
#5
(no author information available yet)
INTRODUCTION: Worldwide, more than 20 million patients undergo groin hernia repair annually. The many different approaches, treatment indications and a significant array of techniques for groin hernia repair warrant guidelines to standardize care, minimize complications, and improve results. The main goal of these guidelines is to improve patient outcomes, specifically to decrease recurrence rates and reduce chronic pain, the most frequent problems following groin hernia repair. They have been endorsed by all five continental hernia societies, the International Endo Hernia Society and the European Association for Endoscopic Surgery...
January 12, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29330716/long-term-survival-of-patients-with-thin-t1-cutaneous-melanomas-a-breslow-thickness-cut-point-of-0-8%C3%A2-mm-separates-higher-risk-and-lower-risk-tumors
#6
Serigne N Lo, Richard A Scolyer, John F Thompson
BACKGROUND: Counterintuitively, more deaths from melanoma occur among patients with thin (T1) primary melanomas (≤ 1 mm) than among those with thick primary melanoma because the great majority present with T1 tumors. Therefore, it is important to stratify their risk as accurately as possible to guide their management and follow-up. This study sought to explore the relationship between tumor thickness and prognosis for patients with thin primary melanomas. METHODS: A retrospective, single-institution study investigated 6263 patients with cutaneous melanoma (including 2117 T1 cases) who had a minimum follow-up period of 10 years...
January 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29325423/early-functional-radiological-outcomes-and-satisfaction-rates-of-total-ankle-arthroplasty-in-an-asian-population
#7
Shi Ming Tan, Hamid Rahmatullah Bin Abdul Razak, Inderjeet Singh Rikhraj
BACKGROUND: Few studies have outlined the outcomes and complications in Asians undergoing total ankle arthroplasty. This study reports the functional, radiological outcomes and satisfaction rates in our Asian population. METHODS: Patients who underwent primary total ankle arthroplasty from 2007 to 2013 were recruited. Outcomes evaluated were the AOFAS Ankle-Hindfoot Score (AHS), Visual Analogue Scale(VAS), and the Short Form 36 (SF-36)questionnaire. Outcome scores were collected prospectively up to 2 years...
January 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29324320/first-survey-of-forensically-important-insects-from-human-corpses-in-shiraz-iran
#8
Mohammad D Moemenbellah-Fard, Davood Keshavarzi, Mehran Fereidooni, Aboozar Soltani
The presence of insects on human cadavers has potential judicial value in medicolegal cases. This research emphasized the important role of insects in postmortem decomposition. It was conducted to investigate the composition and abundance of insects from human corpses during autopsies in legal medicine. It was implemented in the city of Shiraz, south Iran. Insects associated with human corpses were carefully collected and put into labelled vials. They were then identified using valid taxonomic keys. Fifteen outdoor (67%) and indoor discovered cadavers were examined...
January 3, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29323914/path-to-the-desensitized-state-of-ligand-gated-ion-channels-why-are-inhibitory-and-excitatory-receptors-different
#9
Robert S Cantor
The family of pentameric ligand-gated ion channels (pLGICs) includes both inhibitory and excitatory receptors. Electrophysiological methods have explored the time-dependent ion currents induced by their neurotransmitter agonists. Kinetic modeling requires a minimum of three conformational states: resting, active, and desensitized. However, current traces of inhibitory and excitatory pLGICs differ substantially. Reproducing their basic features requires different state connectivity: whether the desensitized state is accessed from the resting or active state...
January 11, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29321021/silver-pig-skin-nanocomposites-and-mesenchymal-stem-cells-suitable-antibiofilm-cellular-dressings-for-wound-healing
#10
Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M Esther Martínez-Pardo, M Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez, Roberto Sánchez-Sánchez
BACKGROUND: Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation is one of the main risks and particularly problematic because it confers protection to microorganisms against antibiotics. One avenue to prevent bacterial colonization of wounds is the use of silver nanoparticles (AgNPs); which have proved to be effective against non-multidrug-resistant and multidrug-resistant bacteria...
January 10, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29319337/reliable-change-and-minimum-clinically-important-difference-mcid-of-the-repeatable-battery-for-the-assessment-of-neuropsychology-status-rbans-in-a-heterogeneous-dementia-sample-support-for-reliable-change-methods-but-not-the-mcid
#11
Megan E O'Connell, Benjamin Gould, Jake Ursenbach, Joe Enright, Debra G Morgan
We compare reliable change scores and recently published anchor-based cutoffs for minimum clinically important difference (MCID) for the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) in a sample of patients diagnosed with various forms of dementia. For memory clinic patients with dementia evaluated twice over a one-year interval (N = 53), observed retest RBANS index scores were compared with predicted retest index scores based on regression formulae developed from cognitively healthy older adults...
January 10, 2018: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/29315999/long-term-safety-and-efficacy-of-acotiamide-in-functional-dyspepsia-postprandial-distress-syndrome-results-from-the-european-phase-3-open-label-safety-trial
#12
J Tack, J Pokrotnieks, G Urbonas, C Banciu, V Yakusevich, I Bunganic, H Törnblom, Y Kleban, P Eavis, M Tsuchikawa, T Miyagawa
BACKGROUNDS: Acotiamide is a novel acetylcholinesterase inhibitor for treatment of postprandial distress syndrome (PDS) symptoms of functional dyspepsia (FD). This European phase 3 open-label safety trial has been conducted to evaluate the long-term safety of acotiamide and explore the efficacy of acotiamide on PDS symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. METHODS: FD-PDS patients (defined by ROME III criteria) aged ≥18 years with active PDS symptoms and without predominant overlapping symptoms of epigastric pain syndrome and related disorders were enrolled to receive 100 mg acotiamide three times daily for 1 year...
January 8, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29314842/exploration-versus-exploitation-in-global-atomistic-structure-optimization
#13
Mathias Siggaard Jørgensen, Uffe Furlig Larsen, Karsten W Jacobsen, Bjørk Hammer
The ability to navigate vast energy landscapes of molecules, clusters, and solids is a necessity for discovering novel compounds in computational chemistry and materials science. For high-dimensional systems it is only computationally feasibly to search a small portion of the landscape, and hence the search strategy is of critical importance. Introducing Bayesian optimization concepts in an evolutionary algorithm framework, we quantify the concepts of exploration and exploitation in global minimum searches...
January 9, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29314162/a-systems-based-risk-assessment-framework-for-intentional-electromagnetic-interference-iemi-on-critical-infrastructures
#14
Benjamin Donald Oakes, Lars-Göran Mattsson, Per Näsman, Andrés Alayón Glazunov
Modern infrastructures are becoming increasingly dependent on electronic systems, leaving them more vulnerable to electrical surges or electromagnetic interference. Electromagnetic disturbances appear in nature, e.g., lightning and solar wind; however, they may also be generated by man-made technology to maliciously damage or disturb electronic equipment. This article presents a systematic risk assessment framework for identifying possible, consequential, and plausible intentional electromagnetic interference (IEMI) attacks on an arbitrary distribution network infrastructure...
January 3, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29305603/assessing-airflow-sensitivity-to-healthy-and-diseased-lung-conditions-in-a-computational-fluid-dynamics-model-validated-in-vitro
#15
Bora Sul, Zachary Oppito, Shehan Jayasekera, Brian Vanger, Amy Zeller, Michael Morris, Kai Ruppert, Talissa Altes, Vineet Rakesh, Steven Day, Risa J Robinson, Jaques Reifman, Anders Wallqvist
Computational models are useful for understanding respiratory physiology. Crucial to such models are the boundary conditions specifying the flow conditions at truncated airway branches (terminal flow rates). However, most studies make assumptions about these values, which are difficult to obtain in vivo. We developed a computational fluid dynamics (CFD) model of airflows for steady expiration to investigate how terminal flows affect airflow patterns in respiratory airways. First, we measured in vitro airflow patterns in a physical airway model, using particle image velocimetry...
January 5, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29305287/endoscopic-repair-of-partial-thickness-undersurface-tears-of-the-abductor-tendon-clinical-outcomes-with-minimum-2-year-follow-up
#16
David E Hartigan, Itay Perets, Sherwin W Ho, John P Walsh, Leslie C Yuen, Benjamin G Domb
PURPOSE: To report the minimum 2-year outcomes of transtendinous repair of partial-thickness undersurface tears of the abductor tendon using patient-reported outcomes (PROs), visual analog scale (VAS) scores, and patient satisfaction scores. METHODS: All patients who underwent endoscopic transtendinous gluteus medius repair between October 2009 and May 2013 at 1 institution were prospectively evaluated. The exclusion criteria consisted of less than 2 years' follow-up, previous hip surgery, inflammatory arthritis, open surgery, full-thickness abductor tear, and Workers' Compensation patients...
January 2, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29305222/a-novel-method-to-measure-the-external-auditory-canal-normative-data-and-practical-implications
#17
Jason Barnes, Roy T Sabo, Daniel H Coelho
PURPOSE: To accurately measure external auditory canal (EAC) dimensions by high resolution computed tomography (CT), and compare results with a traditional method of EAC measurement. METHODS: Using an advanced multidimensional open source digital imaging and communications in medicine (DICOM) analysis program (OsiriX, Pixmeo, Geneva, Switzerland) 91 adult EACs were analyzed on a previously obtained temporal bone CT scan. Tympanometric data were also recorded for each ear...
December 14, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29303927/preoperative-prediction-of-lymph-nodal-metastases-in-endometrial-carcinoma-is-it-possible-a-literature-review
#18
Rami Fares, Sean Kehoe, Nazem Shams
BACKGROUND: Lymph node status is one of the most important prognostic factors in endometrial cancer and crucial for deciding adjuvant therapy. OBJECTIVE: The aim of the study was to assess the different models used to predict lymphatic nodal disease. SEARCH STRATEGY: A literature search was conducted to detect the relevant studies. INCLUSION CRITERIA: Relevant papers comparing the preoperative modality with the final histopathological results including randomized clinical trials, case-control studies, and any publications with a minimum of 50 patients in the report...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29303081/a-new-approach-to-enhance-the-solubility-of-famotidine-tablet-by-using-naturally-isolated-pear-starch
#19
Anjali Kushwaha, Manjul Pratap Singh
PURPOSE- The solubility of drug is affected by various excipients presents in formulation. In case of tablets the role of binders is very important for solubility of dosage form as well as drug. Thus in following study an attempt is made to improve the solubility and dissolution rate of a drug by use of natural excipients. The starch was extracted from the Pear fruits and used as a binder in different concentrations, in famotidine tablets and evaluate them. There are some recent patents on modified starch (WO2011002730A1), directly compressed starch (US6455069B1), pre-compacted starches (US4072535A), which helped in my study...
January 4, 2018: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29301782/diffusion-weighted-imaging-of-brain-metastasis-from-lung-cancer-correlation-of-mri-parameters-with-the-histologic-type-and-gene-mutation-status
#20
W S Jung, C H Park, C-K Hong, S H Suh, S J Ahn
BACKGROUND AND PURPOSE: Development of noninvasive imaging biomarkers indicating the histology and the gene mutation status of brain metastasis from lung cancer is important. We aimed to investigate diffusion-weighted imaging parameters as predictors of the histology and gene mutations of brain metastasis from lung cancer. MATERIALS AND METHODS: DWI data for 74 patients with brain metastasis from lung cancer were retrospectively reviewed. The patients were first grouped according to the primary tumor histology (adenocarcinoma, small-cell lung cancer, squamous cell carcinoma), and those with adenocarcinoma were further divided into epidermal growth factor receptor (EFGR) mutation-positive and wild type groups...
January 4, 2018: AJNR. American Journal of Neuroradiology
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