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https://www.readbyqxmd.com/read/30012973/curcumin-for-the-management-of-periodontitis-and-early-acpa-positive-rheumatoid-arthritis-killing-two-birds-with-one-stone
#1
REVIEW
Eleni Asteriou, Athanasios Gkoutzourelas, Athanasios Mavropoulos, Christina Katsiari, Lazaros I Sakkas, Dimitrios P Bogdanos
We propose curcumin as a preventive measure to avoid/manage periodontitis (PD), and as a natural immunosuppressant for rheumatoid arthritis (RA). PD, mainly caused by Porphyromonas gingivalis forming biofilm and leading to tooth decay, is a major public health issue and a risk factor for the development of RA in humans. P. gingivalis is able to trigger experimental autoimmune arthritis in animal models and in humans can induce citrullinated peptides, which not only are a source of anti-citrullinated antibodies (ACPAs), but also participate in autoreactive responses and disease development...
July 16, 2018: Nutrients
https://www.readbyqxmd.com/read/30001174/igm-cleavage-by-streptococcus-suis-reduces-igm-bound-to-the-bacterial-surface-and-is-a-novel-complement-evasion-mechanism
#2
Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter-Valentin Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann, Christoph Georg Baums
Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis ) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutagenesis of a cysteine in the putative active center of IdeSsuis abrogated IgM cleavage completely. In contrast to wt rIdeSsuis , point mutated rIdeSsuis _C195S did not reduce complement-mediated hemolysis indicating that complement inhibition by rIdeSsuis depends on the IgM proteolytic activity...
July 12, 2018: Virulence
https://www.readbyqxmd.com/read/29990310/selective-disruption-of-tlr2-myd88-interaction-inhibits-inflammation-and-attenuates-alzheimer-s-pathology
#3
Suresh B Rangasamy, Malabendu Jana, Avik Roy, Grant T Corbett, Madhuchhanda Kundu, Sujyoti Chandra, Susanta Mondal, Sridevi Dasarathi, Elliott J Mufson, Rama K Mishra, Chi-Hao Luan, David A Bennett, Kalipada Pahan
Induction of TLR2 activation depends on its association with adapter protein MyD88. We have found that levels of TLR2 and MyD88 are elevated in the hippocampus and cortex of Alzheimer's disease (AD) patients and 5XFAD mouse model of AD. Since there is no specific inhibitor of TLR2, to target induced TLR2 from therapeutic angle, we engineered a peptide corresponding to the TLR2-interacting domain of MyD88 (TIDM) that binds to the BB loop of only TLR2, but not other TLRs. Interestingly, wild type (wt) TIDM peptide inhibited microglial activation induced by fibrillar Aβ1-42 and lipoteichoic acid, but not 1-methyl-4-phenylpyridinium, double-stranded RNA, bacterial lipopolysaccharide, flagellin, and CpG DNA...
July 10, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29985244/intra-articular-gentamicin-loaded-pla-microparticle-injection-for-the-treatment-of-septic-arthritis-in-rabbits
#4
Pierre-Sylvain Marcheix, Christian Martin, Fabrice Fiorenza, Xiaoling Leclercq, Franck Sturtz
BACKGROUND: Because local delivery of drugs induces high concentrations, it could be helpful to apply these delivery systems to the treatment of septic arthritis by antibiotics. Thus, a gentamicin-loaded polymer was tested in a rabbit model of Staphylococcus aureus septic arthritis. METHODS: Thirty New Zealand rabbits were split into five groups: A: infection only; B: infection and systemic gentamicin treatment; C: infection and unloaded polymer and systemic gentamicin treatment; D: infection and gentamicin-loaded polymer only; and E: no infection and unloaded polymer...
July 2, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29966270/gut-microbiome-and-cardiovascular-diseases
#5
REVIEW
Naofumi Yoshida, Tomoya Yamashita, Ken-Ichi Hirata
Recent evidence has suggested that the gut microbiome is involved in human health and diseases, such as inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, and type 2 diabetes. Cardiovascular diseases, which are associated with high morbidity and mortality across the world, are no exception. Increasing evidence has suggested a strong relationship between the gut microbiome and the progression of cardiovascular diseases. We first reported such a relationship with coronary artery disease two years ago...
June 29, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29963294/citrullination-as-a-plausible-link-to-periodontitis-rheumatoid-arthritis-atherosclerosis-and-alzheimer-s-disease
#6
REVIEW
Ingar Olsen, Sim K Singhrao, Jan Potempa
Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer's disease (AD) are examples of complex human diseases with chronic inflammatory components in their etiologies. The initial trigger of inflammation that progresses to these diseases remains unresolved. Porphyromonas gingivalis is unique in its ability to secrete the P. gingivalis- derived peptidyl arginine deiminase (PPAD) and consequently offers a plausible and exclusive link to these diseases through enzymatic conversion of arginine to citrulline...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29959172/tuberculous-arthritis-negative-xpert-mtb-rif-assay-does-not-rule-out-infection
#7
Rebecca Davis, Clare Higgens, Catherine Cosgrove, Joshua Shur, Paul Arkell
We present a case of a 31-year-old man of Indian origin with no previous medical history who presented with an inflamed knee. Treatment for bacterial infection was unsuccessful, and needle aspiration of the left knee effusion/collection was smear and culture positive for tuberculosis (TB), despite Xpert MTB/RIF being falsely negative. The patient was commenced on quadruple therapy for TB and within 2 months had improved significantly with no clinical evidence of ongoing inflammation.
June 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29951326/the-risk-of-immunosuppression-a-case-of-salmonella-meningitis
#8
Joshua Dower, David P Lerner, Tamar Geva, Kenneth Wener
Salmonella meningitis is a rare infection, particularly in adults. We report the case of a 75-year-old female with a history of rheumatoid arthritis on TNF-antagonist immunosuppressive therapy who initially presented to the hospital for management of back and leg pain and was ultimately diagnosed with bacterial meningitis secondary to Salmonella species infection. She was treated with ceftriaxone with slow improvement in neurological function. Though the source of infection was never clearly identified from multiple imaging studies, we suspect the severity of her presentation was due to her history of TNF-antagonist use...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29941463/caspases-1-and-caspase-11-mediate-pyroptosis-inflammation-and-control-of-brucella-joint-infection
#9
Carolyn A Lacey, William J Mitchell, Alexis S Dadelahi, Jerod A Skyberg
Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a zoonotic disease for which arthritis is the most common focal complication in humans. Here we investigated the role of inflammasomes and their effectors, including IL-1, IL-18 and pyroptosis, on inflammation and control of infection during Brucella -induced arthritis. Early in infection, both caspase-1 and caspase-11 were found to initiate joint inflammation and pro-inflammatory cytokine production. However, by one week post-infection caspase-1 and caspase-11 also contributed to control of Brucella joint infection...
June 25, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29914930/reduction-of-articular-and-systemic-inflammation-by-kava-241-in-porphyromonas-gingivalis-induced-arthritis-murine-model
#10
Olivier Huck, Jian You, Xianxian Han, Bin Cai, James Panek, Salomon Amar
Rheumatoid arthritis (RA) is an inflammatory disease that has been linked to several risk factors including periodontitis. Identification of new anti-inflammatory compounds to treat arthritis is needed. We had previously demonstrated the beneficial effect of Kava-241, a kavain derived compound, in the management of Porphyromonas gingivalis induced periodontitis. The present study evaluated systemic and articular effects of Kava-241 in an infective arthritis murine model triggered by P.gingivalis bacterial inoculation and primed with collagen antibody cocktail (CIA) to induce joint inflammation and tissular destruction...
June 18, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29911021/-mycobacterium-avium-subspecies-paratuberculosis-a-possible-causative-agent-in-human-morbidity-and-risk-to-public-health-safety
#11
REVIEW
Mary Garvey
Mycobacterium avium subspecies paratuberculosis is a bacterial parasite and the causative agent of paratuberculosis, a disease predominately found in cattle and sheep. Infection with this microorganism results in substantial farming economic losses and animal morbidity. The link between infection with this pathogen and human disease has been theorised for many years with Crohn's disease being one of many suspected resultant conditions. Mycobacterium avium may be spread from animal to human hosts by water and foodborne transmission routes, where the foodborne route of exposure represents a significant risk for susceptible populations, namely children and the immune-compromised...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29903680/-non-infective-endocarditis
#12
A Le Bot, P Jégo, E Donal, E Flécher, M Revest, P Tattevin
Non-infective endocarditis, also referred to as non-bacterial thrombotic endocarditis, represent a wide range of rare pathologies, often severe. This review gathered the data available in the literature, to decipher the major information collected on the pathophysiology, the diagnosis and the treatment of these heterogeneous diseases, often misdiagnosed. Characteristics of non-infective endocarditis are similar to infective endocarditis in terms of valvular lesions (mostly left-sided, with regurgitations and vegetations), and their complications (embolism)...
June 11, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29903042/streptococcus-suis-cps7-an-emerging-virulent-sequence-type-st29-shows-a-distinct-igm-determined-pattern-of-bacterial-survival-in-blood-of-piglets-during-the-early-adaptive-immune-response-after-weaning
#13
Karoline Rieckmann, Anna Seydel, Kristin Szewczyk, Kerstin Klimke, Viktoria Rungelrath, Christoph Georg Baums
Streptococcus (S.) suis is an important porcine pathogen causing meningitis, arthritis and septicemia. As cps7 emerged recently in Germany in association with severe herd problems, the objective of this study was to characterize the geno- and phenotype of invasive cps7 strains. Twenty cps7 strains were isolated from diseased pigs from different farms with S. suis herd problems due to meningitis and other pathologies. Eighteen of the cps7 isolates belonged to sequence type (ST) 29. Most of these cps7 strains secreted a short MRP variant in agreement with a premature stop codon...
June 15, 2018: Veterinary Research
https://www.readbyqxmd.com/read/29899295/impact-of-dietary-cholesterol-on-the-pathophysiology-of-infectious-and-autoimmune-disease
#14
REVIEW
Catherine J Andersen
Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases...
June 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29898765/ten-weeks-of-high-intensity-interval-walk-training-is-associated-with-reduced-disease-activity-and-improved-innate-immune-function-in-older-adults-with-rheumatoid-arthritis-a-pilot-study
#15
David B Bartlett, Leslie H Willis, Cris A Slentz, Andrew Hoselton, Leslie Kelly, Janet L Huebner, Virginia B Kraus, Jennifer Moss, Michael J Muehlbauer, Guillaume Spielmann, William E Kraus, Janet M Lord, Kim M Huffman
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease in which adults have significant joint issues leading to poor health. Poor health is compounded by many factors, including exercise avoidance and increased risk of opportunistic infection. Exercise training can improve the health of patients with RA and potentially improve immune function; however, information on the effects of high-intensity interval training (HIIT) in RA is limited. We sought to determine whether 10 weeks of a walking-based HIIT program would be associated with health improvements as measured by disease activity and aerobic fitness...
June 14, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29891427/long-term-results-of-bacterial-septic-arthritis-of-the-wrist
#16
Mehran Dadras, Christian Böhm, Christoph Wallner, Johannes Maximilian Wagner, Björn Behr, Marcus Lehnhardt, Adrien Daigeler
Septic arthritis of the wrist is a serious condition, yet little is known about its long-term outcome. A retrospective analysis of 22 patients treated for bacterial septic arthritis of the wrist was conducted with subsequent follow-up of 18 patients with a median period of 44 months to assess functional results via DASH-Score and clinical examination. Arthrotomy was used to treat all patients; in 19 patients, multiple operations were needed to cure the infection. Follow-up revealed a mean DASH-score of 34 (SD 22) and a significant correlation with needed surgical radicality and number of needed operations...
May 22, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29876690/differences-in-clinical-pneumocystis-pneumonia-in-rheumatoid-arthritis-and-other-connective-tissue-diseases-suggesting-a-rheumatoid-specific-interstitial-lung-injury-spectrum
#17
Kota Shimada, Kyoko Yokosuka, Takahiro Nunokawa, Shoji Sugii
To compare Pneumocystis pneumonia (PCP) in patients with rheumatoid arthritis (RA) with PCP in patients with non-RA connective tissue diseases (CTDs) in order to clarify the characteristics of the former. We extracted consecutive patients satisfying the following criteria for "clinical PCP": (1) positive plasma β-D-glucan, (2) PCP-compatible computed tomography findings of the lung, and (3) successful treatment with antipneumocystic antibiotics. Patients who underwent methylprednisolone "pulse" therapy or sufficient antibiotics to cure bacterial pneumonia were excluded...
June 6, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29870122/novel-tool-in-rheumatoid-arthritis-diagnosis-the-usage-of-urease-flap-region-peptidomimetics
#18
Iwona Konieczna, Inga Relich, Maciej Durajski, Lukasz Lechowicz, Magdalena Chrapek, Jozef Gaweda, Justyna Fraczyk, Zbigniew J Kaminski
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. Early diagnosis can prevent joint erosion. However, available biomarkers do not always allow for clear distinction between RA and non-RA individuals. It has become known that bacteria/viruses are among the environmental triggers that initiate RA via multiple molecular mechanisms. Thus, to better understand the role of bacteria in RA, we synthetized 6 peptidomimetics of bacterial ureases' flap region. These peptides were then used to distinguish RA patients from healthy people sera by immunoblotting...
June 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29867945/interleukin-33-receptor-st2-deficiency-improves-the-outcome-of-staphylococcus-aureus-induced-septic-arthritis
#19
Larissa Staurengo-Ferrari, Silvia C Trevelin, Victor Fattori, Daniele C Nascimento, Kalil A de Lima, Jacinta S Pelayo, Florêncio Figueiredo, Rubia Casagrande, Sandra Y Fukada, Mauro M Teixeira, Thiago M Cunha, Foo Y Liew, Rene D Oliveira, Paulo Louzada-Junior, Fernando Q Cunha, José C Alves-Filho, Waldiceu A Verri
The ST2 receptor is a member of the Toll/IL-1R superfamily and interleukin-33 (IL-33) is its agonist. Recently, it has been demonstrated that IL-33/ST2 axis plays key roles in inflammation and immune mediated diseases. Here, we investigated the effect of ST2 deficiency in Staphylococcus aureus -induced septic arthritis physiopathology. Synovial fluid samples from septic arthritis and osteoarthritis individuals were assessed regarding IL-33 and soluble (s) ST2 levels. The IL-33 levels in samples from synovial fluid were significantly increased, whereas no sST2 levels were detected in patients with septic arthritis when compared with osteoarthritis individuals...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29862158/severe-bacterial-sepsis-results-in-delayed-diagnosis-of-tuberculous-lymphadenitis-in-a-rheumatoid-arthritis-patient-treated-with-adalimumab
#20
Soichiro Sawamura, Takamitsu Makino, Takamitsu Johno, Junji Yamashita, Daisuke Niimori, Satoshi Fukushima, Hironobu Ihn
Although tumor necrosis factor (TNF)-α inhibitors are effective in patients with rheumatoid arthritis (RA), an increased risk of infections often becomes a serious problem. It is well known that TNF-α inhibitors increase the risk of tuberculosis, but extrapulmonary tuberculosis often induced by them is difficult to diagnose using routine imaging examinations. We described a case of delayed diagnosis of a tuberculous lymphadenitis in a patient with RA treated with TNF-α inhibitor because of the complications of severe bacterial sepsis...
May 2018: Intractable & Rare Diseases Research
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