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https://www.readbyqxmd.com/read/30417696/periodontal-sources-of-citrullinated-antigens-and-tlr-agonists-related-to-ra
#1
Ljubomir Vitkov, Matthias Hannig, Bernd Minnich, Martin Herrmann
Anti-citrullinated protein autoantibodies (ACPA) precede the onset of clinical and subclinical rheumatoid arthritis (RA). ACPA are frequently generated in further chronic inflammatory diseases, e.g. chronic obstructive pulmonary disease, lupus, periodontitis (PD), characterized by citrullination and mucosal as well as systemic autoimmunity against citrullinated proteins. PD is of particular interest, as it exhibits two sources of citrullination, namely peptidylarginine deiminase 4 (PAD4) of periodontal neutrophils and neutrophil extracellular traps (NETs) as well as the PAD of Porphyromonas gingivalis (PPAD)...
November 10, 2018: Autoimmunity
https://www.readbyqxmd.com/read/30402304/acute-streptococcus-mitis-sacroiliitis-in-a-teenager-with-unclear-source-of-bacteremia-a-case-report-and-literature-review
#2
Fatma Al-Farsi, Ibrahim Al-Busaidi, Khalfan Al-Zeedi
Septic arthritis is an orthopedic emergency that is commonly caused by Staphylococcus aureus . Old age, diabetes mellitus, rheumatoid arthritis, prosthetic joint, and recent surgery are the main predisposing risk factors. Most cases of septic arthritis are caused by hematogenous spread of infection. Infectious sacroiliitis is a rare form of septic arthritis which is often clinically challenging to diagnose due its various and nonspecific presentations. Streptococcus mitis belongs to viridans group streptococci (VGS) bacteria, which is a component of body flora that is commonly involved in bacterial endocarditis...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/30360909/systemic-yersinia-pseudotuberculosis-as-a-cause-of-osteomyelitis-in-a-captive-ring-tailed-lemur-lemur-catta
#3
D Walker, J Gibbons, J D Harris, C S Taylor, C Scott, G K Paterson, L R Morrison
Yersinia pseudotuberculosis and Yersinia enterocolitica are ubiquitous pathogens with wildlife and domestic animal reservoirs. Outbreaks of 'non-plague' yersiniosis in man and non-human primates are reported frequently (including zoological specimens and research breeding colonies) and are usually characterized by enteritis, mesenteric lymphadenitis and occasionally organ abscessation. In people, non-septic reactive arthritis is a common sequela to yersiniosis. However, there have been rare reports in people of septic arthritis and osteomyelitis because of active systemic infection with Y...
October 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/30359170/the-oral-microbiota-is-modified-by-systemic-diseases
#4
D T Graves, J D Corrêa, T A Silva
Periodontal diseases are initiated by bacteria that accumulate in a biofilm on the tooth surface and affect the adjacent periodontal tissue. Systemic diseases such as diabetes, rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) increase susceptibility to destructive periodontal diseases. In human studies and in animal models, these diseases have been shown to enhance inflammation in the periodontium and increase the risk or severity of periodontitis. All 3 systemic diseases are linked to a decrease in bacterial taxa associated with health and an increase in taxa associated with disease...
October 25, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30345134/sepsis-and-pleural-empyema-caused-by-streptococcus-pyogenes-after-influenza-a-virus-infection
#5
Fumihiro Ochi, Hisamichi Tauchi, Toshihiro Jogamoto, Hiromitsu Miura, Tomozo Moritani, Kozo Nagai, Eiichi Ishii
Streptococcus pyogenes (also referred to as group A streptococci, GAS) causes severe invasive diseases such as bacteremia, necrotizing fasciitis, pneumonia, osteomyelitis, septic arthritis, and toxic shock syndrome in children. However, there are only a few reports on pleural empyema caused by GAS in children. Here, we report the case of a 4-year-old boy who presented with pleural empyema due to GAS after influenza A virus infection. With intravenous antibiotic administration and continuous chest-tube drainage, followed by video-assisted thoracoscopic surgery, his condition improved...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/30310087/interplay-between-p-gingivalis-f-nucleatum-and-a-actinomycetemcomitans-in-murine-alveolar-bone-loss-arthritis-onset-and-progression
#6
Meinolf Ebbers, Paul M Lübcke, Johann Volzke, Katja Kriebel, Cathleen Hieke, Robby Engelmann, Hermann Lang, Bernd Kreikemeyer, Brigitte Müller-Hilke
Increasing evidence supports the association of periodontitis with rheumatoid arthritis. Even though a prominent role has been postulated for Porphyromonas gingivalis, many bacterial species contribute to the pathogenesis of periodontal disease. We therefore investigated the impact of Porphyromonas gingivalis as well as other major pathobionts on the development of both, periodontitis and arthritis in the mouse. Pathobionts used - either alone or in combination - were Porphyromonas gingivalis, Fusobacterium nucleatum and Aggregatibacter actinomycetemcomintans...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30297828/tgf-%C3%AE-2-downregulates-osteogenesis-under-inflammatory-conditions-in-dental-follicle-stem-cells
#7
Soyoun Um, Joo-Hee Lee, Byoung-Moo Seo
Bone formation is important for the reconstruction of bone-related structures in areas that have been damaged by inflammation. Inflammatory conditions such as those that occur in patients with rheumatoid arthritis, cystic fibrosis, and periodontitis have been shown to inhibit osteoblastic differentiation. This study focussed on dental follicle stem cells (DFSCs), which are found in developing tooth germ and participate in the reconstruction of alveolar bone and periodontal tissue in periodontal disease. After bacterial infection of inflamed dental tissue, the destruction of bone was observed...
October 9, 2018: International Journal of Oral Science
https://www.readbyqxmd.com/read/30282764/lyme-disease-diagnosis-and-management
#8
Amy Louise Ross Russell, Matthew Dryden, Ashwin Arnold Pinto, Joanna Lovett
Lyme disease (borreliosis) is a tick-borne bacterial infection caused by the spirochaete Borrelia burgdoferi , transmitted by hard-backed Ixodes ticks. Actual numbers of cases are increasing and it appears that the distribution across the UK is widening; however, it occurs most frequently in area of woodland, with temperate climate. It typically presents in mid to late summer. Lyme disease is a multisystem disease. The nervous system is the second most commonly affected system after the skin. Other systemic manifestations, such as carditis, keratitis, uveitis and inflammatory arthritis, rarely occur in European Lyme disease...
October 3, 2018: Practical Neurology
https://www.readbyqxmd.com/read/30277901/native-adult-hip-with-bacterial-septic-arthritis
#9
Zachary C Lum, Alvin K Shieh, John P Meehan
No abstract text is available yet for this article.
October 2, 2018: JBJS Reviews
https://www.readbyqxmd.com/read/30250232/detection-and-characterization-of-bacterial-nucleic-acids-in-culture-negative-synovial-tissue-and-fluid-samples-from-rheumatoid-arthritis-or-osteoarthritis-patients
#10
Yan Zhao, Bin Chen, Shufeng Li, Lanxiu Yang, Dequan Zhu, Ye Wang, Haiying Wang, Tao Wang, Bin Shi, Zhongtao Gai, Jun Yang, Xueyuan Heng, Junjie Yang, Lei Zhang
Human intestinal microbes can mediate development of arthritis - Studies indicate that certain bacterial nucleic acids may exist in synovial fluid (SF) and could be involved in arthritis, although the underlying mechanism remains unclear. To characterize potential SF bacterial nucleic acids, we used 16S rRNA gene amplicon sequencing to assess bacterial nucleic acid communities in 15 synovial tissue (ST) and 110 SF samples from 125 patients with rheumatoid arthritis (RA) and 16 ST and 42 SF samples from 58 patients with osteoarthritis (OA)...
September 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30247225/detection-of-bacterial-dna-in-septic-arthritis-samples-using-the-mycrobiota-platform
#11
Stefan A Boers, Linda Reijnen, Bjorn L Herpers, John P Hays, Ruud Jansen
No abstract text is available yet for this article.
September 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/30238519/intestinal-microbiota-profiling-and-predicted-metabolic-dysregulation-in-psoriasis-patients
#12
Yi-Ju Chen, Hsiu J Ho, Ching-Hung Tseng, Zi-Lun Lai, Jeng-Jer Shieh, Chun-Ying Wu
OBJECTIVES: The intestinal microbiota has been known to involve in obesity and host immune response. We aimed to investigate the intestinal microbiota and potential genetic function in relation to clinical presentation in psoriasis patients. METHODS: Fecal microbiota and predicted genetic function inferred from high-throughput 16S ribosomal RNA sequencing were analyzed between psoriasis (n=32) and age-, gender- and body mass index (BMI)-matched non-psoriasis subjects (n=64), from a referral medical center...
September 20, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/30238343/novel-diagnostic-elisa-test-for-discrimination-between-infections-with-yersinia-enterocolitica-and-yersinia-pseudotuberculosis
#13
Tomasz Wielkoszynski, Aliyeh Moghaddam, Assar Bäckman, Jessica Broden, Rafał Piotrowski, Renata Mond-Paszek, Alexander Kozarenko, Tor Ny, Malgorzata Wilczynska
Yersiniosis is a foodborne infection caused by Yersinia enterocolitica or Yersinia pseudotuberculosis. Although yersiniosis is most often self-limiting, some patients develop chronic infections, such as reactive arthritis, glomerulonephritis, or myocarditis, which require an antibiotic treatment. Whereas early infections can be diagnosed by direct detection of bacteria, chronic infections can only be identified by serological tests. At this point, a serological method for differentiation between infections with the two Yersinia species is important since antibiotic susceptibility of these bacteria is different...
December 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30237466/impact-of-porphyromonas-gingivalis-peptidylarginine-deiminase-on-bacterial-biofilm-formation-epithelial-cell-invasion-and-epithelial-cell-transcriptional-landscape
#14
Ardita Aliko, Marta Kamińska, Brith Bergum, Katarzyna Gawron, Małgorzata Benedyk, Richard J Lamont, Stanisław Malicki, Nicolas Delaleu, Jan Potempa, Piotr Mydel
Peptidylarginine deiminase (PPAD) is a virulence factor unique to pathogenic Porphyromonas species, especially P. gingivalis. Mechanistically, PPAD activity, in conjunction with Arg-specific gingipains, generates protein fragments with citrullinated C-termini. Such polypeptides are potential de novo epitopes that are key drivers of rheumatoid arthritis. This process could underlie the observed clinical association between rheumatoid arthritis and periodontitis. However, the role of PPAD in host colonization by P...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30231060/subgingival-microbiome-of-rheumatoid-arthritis-patients-in-relation-to-their-disease-status-and-periodontal-health
#15
Kathrin Beyer, Egija Zaura, Bernd W Brandt, Mark J Buijs, Johan G Brun, Wim Crielaard, Anne Isine Bolstad
OBJECTIVE: Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that share common risk factors. However, the bidirectional relationship between RA and periodontal disease is not fully understood. This study was undertaken to describe the bacterial component of the subgingival microbiome in RA patients and to relate this to RA disease activity and periodontal status. METHODS: Patients with chronic established RA (N = 78) were periodontally examined and their subgingival plaque samples were collected; their clinical and laboratory data on RA status and medication were obtained from medical records...
2018: PloS One
https://www.readbyqxmd.com/read/30189157/serum-amyloid-a-contributes-to-chronic-apical-periodontitis-via-tlr2-and-tlr4
#16
K Hirai, H Furusho, N Kawashima, S Xu, M C de Beer, R Battaglino, T Van Dyke, P Stashenko, H Sasaki
In the current concept of bacterial infections, pathogen-associated molecular patterns (PAMPs) derived from pathogens and damage-associated molecular patterns (DAMPs) released from damaged/necrotic host cells are crucial factors in induction of innate immune responses. However, the implication of DAMPs in apical and marginal periodontitis is unknown. Serum amyloid A (SAA) is a DAMP that is involved in the development of various chronic inflammatory diseases, such as rheumatoid arthritis. In the present study, we tested whether SAA is involved in the pathogenesis of periapical lesions, using human periapical surgical specimens and mice deficient in SAA and Toll-like receptors (TLR)...
September 6, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30158563/author-correction-interrupting-oral-infection-of-porphyromonas-gingivalis-with-anti-fima-antibody-attenuates-bacterial-dissemination-to-the-arthritic-joint-and-improves-experimental-arthritis
#17
Sang Hoon Jeong, Yoojun Nam, Hyerin Jung, Juryun Kim, Yeri Alice Rim, Narae Park, Kijun Lee, Seungjin Choi, Yeonsue Jang, Yena Kim, Ji-Hoi Moon, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju
After online publication of this article, the authors noticed an error in the Figure section. The correct statement of this article should have read as below.
August 29, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30148440/risk-of-hospitalisation-for-serious-bacterial-infections-in-patients-with-rheumatoid-arthritis-treated-with-biologics-analysis-from-the-record-linkage-on-rheumatic-disease-study-of-the-italian-society-for-rheumatology
#18
Greta Carrara, Alessandra Bortoluzzi, Garifallia Sakellariou, Ettore Silvagni, Anna Zanetti, Marcello Govoni, Carlo Alberto Scirè
OBJECTIVES: The aims of this study were to define the risk of serious bacterial infections in patients receiving specific biological disease-modifying anti-rheumatic drugs (bDMARDs) and evaluating the effect of concomitant synthetic DMARDs (sDMARDs) in a large population-based sample of rheumatoid arthritis (RA) deriving from an administrative health database. METHODS: Data were extracted from health databases of Lombardy Region, Italy (2004-2013), as a part of the RECord-linkage On Rheumatic Diseases (RECORD) study...
July 18, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/30147733/the-ethnopharmacological-and-nutraceutical-relevance-of-launaea-taraxacifolia-willd-amin-ex-c-jeffrey
#19
REVIEW
Michael Buenor Adinortey, Justice Kwabena Sarfo, Jeffery Kwarteng, Cynthia Ayefoumi Adinortey, William Ekloh, Lydia Enyonam Kuatsienu, Alexander Kwadwo Nyarko
Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30114516/protective-effects-of-paederia-scandens-extract-on-rheumatoid-arthritis-mouse-model-by-modulating-gut-microbiota
#20
Man Xiao, Xiaopeng Fu, Yali Ni, Jifeng Chen, Shaoqing Jian, Liankai Wang, Li Li, Guankui Du
ETHNOPHARMACOLOGICAL RELEVANCE: Paederia scandens (Lour.) Merr. (P. scandens) has been traditionally used to treat the pain of rheumatism. AIM OF THE STUDY: The purpose of this study was to investigate the possible influences of P. scandens on the progression of rheumatoid arthritis (RA), inflammatory responses and gut bacterial communities in RA mouse model. MATERIALS AND METHODS: collagen-induced arthritis (CIA) mice were orally administered with P...
November 15, 2018: Journal of Ethnopharmacology
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