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https://www.readbyqxmd.com/read/30238519/intestinal-microbiota-profiling-and-predicted-metabolic-dysregulation-in-psoriasis-patients
#1
Yi-Ju Chen, Hsiu J Ho, Ching-Hung Tseng, Zi-Lun Lai, Jeng-Jer Shieh, Chun-Ying Wu
OBJECTIVES: The intestinal microbiota has been known to involve in obesity and host immune response. We aimed to investigate the intestinal microbiota and potential genetic function in relation to clinical presentation in psoriasis patients. METHODS: Fecal microbiota and predicted genetic function inferred from high-throughput 16S ribosomal RNA sequencing were analyzed between psoriasis (n=32) and age-, gender- and body mass index (BMI)-matched non-psoriasis subjects (n=64), from a referral medical center...
September 20, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/30238343/novel-diagnostic-elisa-test-for-discrimination-between-infections-with-yersinia-enterocolitica-and-yersinia-pseudotuberculosis
#2
Tomasz Wielkoszynski, Aliyeh Moghaddam, Assar Bäckman, Jessica Broden, Rafał Piotrowski, Renata Mond-Paszek, Alexander Kozarenko, Tor Ny, Malgorzata Wilczynska
Yersiniosis is a foodborne infection caused by Yersinia enterocolitica or Yersinia pseudotuberculosis. Although yersiniosis is most often self-limiting, some patients develop chronic infections, such as reactive arthritis, glomerulonephritis, or myocarditis, which require an antibiotic treatment. Whereas early infections can be diagnosed by direct detection of bacteria, chronic infections can only be identified by serological tests. At this point, a serological method for differentiation between infections with the two Yersinia species is important since antibiotic susceptibility of these bacteria is different...
September 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/30237466/impact-of-porphyromonas-gingivalis-peptidylarginine-deiminase-on-bacterial-biofilm-formation-epithelial-cell-invasion-and-epithelial-cell-transcriptional-landscape
#3
Ardita Aliko, Marta Kamińska, Brith Bergum, Katarzyna Gawron, Małgorzata Benedyk, Richard J Lamont, Stanisław Malicki, Nicolas Delaleu, Jan Potempa, Piotr Mydel
Peptidylarginine deiminase (PPAD) is a virulence factor unique to pathogenic Porphyromonas species, especially P. gingivalis. Mechanistically, PPAD activity, in conjunction with Arg-specific gingipains, generates protein fragments with citrullinated C-termini. Such polypeptides are potential de novo epitopes that are key drivers of rheumatoid arthritis. This process could underlie the observed clinical association between rheumatoid arthritis and periodontitis. However, the role of PPAD in host colonization by P...
September 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30231060/subgingival-microbiome-of-rheumatoid-arthritis-patients-in-relation-to-their-disease-status-and-periodontal-health
#4
Kathrin Beyer, Egija Zaura, Bernd W Brandt, Mark J Buijs, Johan G Brun, Wim Crielaard, Anne Isine Bolstad
OBJECTIVE: Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that share common risk factors. However, the bidirectional relationship between RA and periodontal disease is not fully understood. This study was undertaken to describe the bacterial component of the subgingival microbiome in RA patients and to relate this to RA disease activity and periodontal status. METHODS: Patients with chronic established RA (N = 78) were periodontally examined and their subgingival plaque samples were collected; their clinical and laboratory data on RA status and medication were obtained from medical records...
2018: PloS One
https://www.readbyqxmd.com/read/30189157/serum-amyloid-a-contributes-to-chronic-apical-periodontitis-via-tlr2-and-tlr4
#5
K Hirai, H Furusho, N Kawashima, S Xu, M C de Beer, R Battaglino, T Van Dyke, P Stashenko, H Sasaki
In the current concept of bacterial infections, pathogen-associated molecular patterns (PAMPs) derived from pathogens and damage-associated molecular patterns (DAMPs) released from damaged/necrotic host cells are crucial factors in induction of innate immune responses. However, the implication of DAMPs in apical and marginal periodontitis is unknown. Serum amyloid A (SAA) is a DAMP that is involved in the development of various chronic inflammatory diseases, such as rheumatoid arthritis. In the present study, we tested whether SAA is involved in the pathogenesis of periapical lesions, using human periapical surgical specimens and mice deficient in SAA and Toll-like receptors (TLR)...
September 6, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/30158563/author-correction-interrupting-oral-infection-of-porphyromonas-gingivalis-with-anti-fima-antibody-attenuates-bacterial-dissemination-to-the-arthritic-joint-and-improves-experimental-arthritis
#6
Sang Hoon Jeong, Yoojun Nam, Hyerin Jung, Juryun Kim, Yeri Alice Rim, Narae Park, Kijun Lee, Seungjin Choi, Yeonsue Jang, Yena Kim, Ji-Hoi Moon, Seung Min Jung, Sung-Hwan Park, Ji Hyeon Ju
After online publication of this article, the authors noticed an error in the Figure section. The correct statement of this article should have read as below.
August 29, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/30148440/risk-of-hospitalisation-for-serious-bacterial-infections-in-patients-with-rheumatoid-arthritis-treated-with-biologics-analysis-from-the-record-linkage-on-rheumatic-disease-study-of-the-italian-society-for-rheumatology
#7
Greta Carrara, Alessandra Bortoluzzi, Garifallia Sakellariou, Ettore Silvagni, Anna Zanetti, Marcello Govoni, Carlo Alberto Scirè
OBJECTIVES: The aims of this study were to define the risk of serious bacterial infections in patients receiving specific biological disease-modifying anti-rheumatic drugs (bDMARDs) and evaluating the effect of concomitant synthetic DMARDs (sDMARDs) in a large population-based sample of rheumatoid arthritis (RA) deriving from an administrative health database. METHODS: Data were extracted from health databases of Lombardy Region, Italy (2004-2013), as a part of the RECord-linkage On Rheumatic Diseases (RECORD) study...
July 18, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/30147733/the-ethnopharmacological-and-nutraceutical-relevance-of-launaea-taraxacifolia-willd-amin-ex-c-jeffrey
#8
REVIEW
Michael Buenor Adinortey, Justice Kwabena Sarfo, Jeffery Kwarteng, Cynthia Ayefoumi Adinortey, William Ekloh, Lydia Enyonam Kuatsienu, Alexander Kwadwo Nyarko
Launaea taraxacifolia (Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. The plant, commonly found in West Africa, is used in the management of many diseases including cardiovascular, respiratory, haematological, endocrine, and metabolic diseases in Ghana, Nigeria, Benin, Serra Leone, and Senegal. This piece provides comprehensive and updated information on the traditional uses, phytochemical constituents, and pharmacological and toxicological information available on Launaea taraxacifolia to support its medicinal uses and also unearth knowledge gaps for future studies...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/30114516/protective-effects-of-paederia-scandens-extract-on-rheumatoid-arthritis-mouse-model-by-modulating-gut-microbiota
#9
Man Xiao, Xiaopeng Fu, Yali Ni, Jifeng Chen, Shaoqing Jian, Liankai Wang, Li Li, Guankui Du
ETHNOPHARMACOLOGICAL RELEVANCE: Paederia scandens (Lour.) Merr. (P. scandens) has been traditionally used to treat the pain of rheumatism. AIM OF THE STUDY: The purpose of this study was to investigate the possible influences of P. scandens on the progression of rheumatoid arthritis (RA), inflammatory responses and gut bacterial communities in RA mouse model. MATERIALS AND METHODS: collagen-induced arthritis (CIA) mice were orally administered with P...
November 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30111212/procalcitonin-may-not-be-a-differential-diagnostic-marker-for-bacterial-infection-in-febrile-patients-with-chronic-gouty-arthritis
#10
Jing Zhang, Cheng Zhao, Tong Wu, Jiang Su, Xiaodan Wu, Jian Liu, Jing Zhu, Bin Zhou
Objective This study aimed to examine the diagnostic value of serum procalcitonin (PCT) levels for identifying bacterial infection in febrile patients with chronic gouty arthritis. Methods Sixty-six febrile patients with chronic gouty arthritis were divided into non-bacterial infection (n = 45) and bacterial infection groups (n = 21). PCT levels were measured by an immunoassay. Other laboratory parameters, including the erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cells (WBCs), and the neutrophil ratio were extracted from medical records...
August 15, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/30058852/determination-of-reference-intervals-for-fluid-analysis-and-cytologic-evaluation-variables-in-synovial-fluid-samples-obtained-from-carpal-and-tarsal-joints-in-commercial-nonlame-growing-swine
#11
Paisley Canning, Austin Viall, Katie O'Brien, Darin Madson, Kristin Skoland, Adam Krull, Daniel Linhares, Phillip Gauger, Alejandro Ramirez, Locke Karriker
OBJECTIVE To determine reference intervals for total nucleated cell count, total protein concentration, pH, RBC count, and percentages of neutrophils, lymphocytes, and large mononuclear cells in synovial fluid samples (SFSs) obtained from the carpal and tarsal joints of healthy swine. ANIMALS 54 healthy commercial finisher pigs that had no evidence of lameness or gross joint swelling. PROCEDURES Each pig was anesthetized, and SFSs were collected from 1 carpal and 1 tarsal joint for fluid analysis, cytologic evaluation, bacterial culture, and PCR analyses for common swine joint pathogens...
August 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/30012973/curcumin-for-the-management-of-periodontitis-and-early-acpa-positive-rheumatoid-arthritis-killing-two-birds-with-one-stone
#12
REVIEW
Eleni Asteriou, Athanasios Gkoutzourelas, Athanasios Mavropoulos, Christina Katsiari, Lazaros I Sakkas, Dimitrios P Bogdanos
We propose curcumin as a preventive measure to avoid/manage periodontitis (PD), and as a natural immunosuppressant for rheumatoid arthritis (RA). PD, mainly caused by Porphyromonas gingivalis forming biofilm and leading to tooth decay, is a major public health issue and a risk factor for the development of RA in humans. P. gingivalis is able to trigger experimental autoimmune arthritis in animal models and in humans can induce citrullinated peptides, which not only are a source of anti-citrullinated antibodies (ACPAs), but also participate in autoreactive responses and disease development...
July 16, 2018: Nutrients
https://www.readbyqxmd.com/read/30001174/igm-cleavage-by-streptococcus-suis-reduces-igm-bound-to-the-bacterial-surface-and-is-a-novel-complement-evasion-mechanism
#13
Viktoria Rungelrath, Christine Weiße, Nicole Schütze, Uwe Müller, Marita Meurer, Manfred Rohde, Jana Seele, Peter Valentin-Weigand, Michael Kirschfink, Andreas Beineke, Wieland Schrödl, René Bergmann, Christoph Georg Baums
Streptococcus suis (S. suis) causes meningitis, arthritis and endocarditis in piglets. The aim of this study was to characterize the IgM degrading enzyme of S. suis (IdeSsuis ) and to investigate the role of IgM cleavage in evasion of the classical complement pathway and pathogenesis. Targeted mutagenesis of a cysteine in the putative active center of IdeSsuis abrogated IgM cleavage completely. In contrast to wt rIdeSsuis , point mutated rIdeSsuis _C195S did not reduce complement-mediated hemolysis indicating that complement inhibition by rIdeSsuis depends on the IgM proteolytic activity...
2018: Virulence
https://www.readbyqxmd.com/read/29990310/selective-disruption-of-tlr2-myd88-interaction-inhibits-inflammation-and-attenuates-alzheimer-s-pathology
#14
Suresh B Rangasamy, Malabendu Jana, Avik Roy, Grant T Corbett, Madhuchhanda Kundu, Sujyoti Chandra, Susanta Mondal, Sridevi Dasarathi, Elliott J Mufson, Rama K Mishra, Chi-Hao Luan, David A Bennett, Kalipada Pahan
Induction of TLR2 activation depends on its association with the adapter protein MyD88. We have found that TLR2 and MyD88 levels are elevated in the hippocampus and cortex of patients with Alzheimer's disease (AD) and in a 5XFAD mouse model of AD. Since there is no specific inhibitor of TLR2, to target induced TLR2 from a therapeutic angle, we engineered a peptide corresponding to the TLR2-interacting domain of MyD88 (TIDM) that binds to the BB loop of only TLR2, and not other TLRs. Interestingly, WT TIDM peptide inhibited microglial activation induced by fibrillar Aβ1-42 and lipoteichoic acid, but not 1-methyl-4-phenylpyridinium, dsRNA, bacterial lipopolysaccharide, flagellin, or CpG DNA...
September 4, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29985244/intra-articular-gentamicin-loaded-pla-microparticle-injection-for-the-treatment-of-septic-arthritis-in-rabbits
#15
Pierre-Sylvain Marcheix, Christian Martin, Fabrice Fiorenza, Xiaoling Leclercq, Franck Sturtz
BACKGROUND: Because local delivery of drugs induces high concentrations, it could be helpful to apply these delivery systems to the treatment of septic arthritis by antibiotics. Thus, a gentamicin-loaded polymer was tested in a rabbit model of Staphylococcus aureus septic arthritis. METHODS: Thirty New Zealand rabbits were split into five groups: A: infection only; B: infection and systemic gentamicin treatment; C: infection and unloaded polymer and systemic gentamicin treatment; D: infection and gentamicin-loaded polymer only; and E: no infection and unloaded polymer...
August 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29966270/gut-microbiome-and-cardiovascular-diseases
#16
REVIEW
Naofumi Yoshida, Tomoya Yamashita, Ken-Ichi Hirata
Recent evidence has suggested that the gut microbiome is involved in human health and diseases, such as inflammatory bowel disease, liver cirrhosis, rheumatoid arthritis, and type 2 diabetes. Cardiovascular diseases, which are associated with high morbidity and mortality across the world, are no exception. Increasing evidence has suggested a strong relationship between the gut microbiome and the progression of cardiovascular diseases. We first reported such a relationship with coronary artery disease two years ago...
June 29, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29963294/citrullination-as-a-plausible-link-to-periodontitis-rheumatoid-arthritis-atherosclerosis-and-alzheimer-s-disease
#17
REVIEW
Ingar Olsen, Sim K Singhrao, Jan Potempa
Periodontitis, rheumatoid arthritis (RA), atherosclerosis (AS), and Alzheimer's disease (AD) are examples of complex human diseases with chronic inflammatory components in their etiologies. The initial trigger of inflammation that progresses to these diseases remains unresolved. Porphyromonas gingivalis is unique in its ability to secrete the P. gingivalis- derived peptidyl arginine deiminase (PPAD) and consequently offers a plausible and exclusive link to these diseases through enzymatic conversion of arginine to citrulline...
2018: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29959172/tuberculous-arthritis-negative-xpert-mtb-rif-assay-does-not-rule-out-infection
#18
Rebecca Davis, Clare Higgens, Catherine Cosgrove, Joshua Shur, Paul Arkell
We present a case of a 31-year-old man of Indian origin with no previous medical history who presented with an inflamed knee. Treatment for bacterial infection was unsuccessful, and needle aspiration of the left knee effusion/collection was smear and culture positive for tuberculosis (TB), despite Xpert MTB/RIF being falsely negative. The patient was commenced on quadruple therapy for TB and within 2 months had improved significantly with no clinical evidence of ongoing inflammation.
June 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29951326/the-risk-of-immunosuppression-a-case-of-salmonella-meningitis
#19
Joshua Dower, David P Lerner, Tamar Geva, Kenneth Wener
Salmonella meningitis is a rare infection, particularly in adults. We report the case of a 75-year-old female with a history of rheumatoid arthritis on TNF-antagonist immunosuppressive therapy who initially presented to the hospital for management of back and leg pain and was ultimately diagnosed with bacterial meningitis secondary to Salmonella species infection. She was treated with ceftriaxone with slow improvement in neurological function. Though the source of infection was never clearly identified from multiple imaging studies, we suspect the severity of her presentation was due to her history of TNF-antagonist use...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29941463/caspases-1-and-caspase-11-mediate-pyroptosis-inflammation-and-control-of-brucella-joint-infection
#20
Carolyn A Lacey, William J Mitchell, Alexis S Dadelahi, Jerod A Skyberg
Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a zoonotic disease for which arthritis is the most common focal complication in humans. Here we investigated the role of inflammasomes and their effectors, including IL-1, IL-18 and pyroptosis, on inflammation and control of infection during Brucella -induced arthritis. Early in infection, both caspase-1 and caspase-11 were found to initiate joint inflammation and pro-inflammatory cytokine production. However, by one week post-infection caspase-1 and caspase-11 also contributed to control of Brucella joint infection...
June 25, 2018: Infection and Immunity
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