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Roux-Y Gastric bypass

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https://www.readbyqxmd.com/read/28921894/macrophage-area-content-and-phenotype-in-hepatic-and-adipose-tissue-in-patients-with-obesity-undergoing-roux-en-y-gastric-bypass
#1
Marianne D Kristensen, Michael T Lund, Merethe Hansen, Steen S Poulsen, Thorkil Ploug, Flemming Dela, Jørn W Helge, Clara Prats
OBJECTIVE: To investigate hepatic and adipose tissue macrophage content in subjects with obesity and the role of adipose tissue macrophages in weight loss-induced improved insulin sensitivity (IS). METHODS: A cross-sectional and a longitudinal study were combined to investigate the role of macrophages in subcutaneous (SAT) and visceral (VAT) adipose tissue and the liver in obesity-induced impaired IS and improvements with weight loss. Macrophage markers (CD68, CD163, and CD206) in SAT, VAT, and the liver from patients with obesity were investigated...
September 18, 2017: Obesity
https://www.readbyqxmd.com/read/28921422/high-incidence-of-secondary-hyperparathyroidism-in-bariatric-patients-comparing-different-procedures
#2
Jih-Hua Wei, Wei-Jei Lee, Keong Chong, Yi-Chih Lee, Shu-Chun Chen, Po-Hsun Huang, Shing-Jong Lin
BACKGROUND: Bariatric surgery is an effective therapy for morbid obesity but may reduce calcium absorption and significantly decrease the bone mineral density. This study examined the prevalence of secondary hyperparathyroidism (SHPT) in obese subjects during follow-up after different bariatric surgeries. We investigated predictors of SHPT. METHODS: We enrolled 1470 obese subjects undergoing bariatric/metabolic surgery with at least 1-year follow-up, including 322 patients undergoing Roux-en-Y gastric bypass (RYGB), 695 undergoing single anastomosis (mini-) gastric bypass (SAGB), 93 undergoing laparoscopic adjustable gastric banding (LAGB), and 360 undergoing sleeve gastrectomy (SG)...
September 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28919979/reversal-of-fibrosis-in-patients-with-nonalcoholic-steatohepatosis-after-gastric-bypass-surgery
#3
Brian M Parker, Jiang Wu, Jing You, David S Barnes, Lisa Yerian, John P Kirwan, Philip R Schauer, Daniel I Sessler
BACKGROUND: Roux-en-Y gastric bypass (RYGB) improves the pathophysiology that contributes to obesity-related nonalcoholic steatohepatitis (NASH). Whether obesity-related fibrosis improves is unclear. We hypothesized that RYGB reverses NASH and fibrosis, and indocyanine green (ICG) clearance provides a sensitive measure for detecting asymptomatic fatty liver disease. METHODS: One hundred six obese adults scheduled for RYGB had preoperative liver function assessed using standard tests and ICG clearance and core liver biopsies obtained during RYGB...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28919184/clinical-significance-of-failure-to-lose-weight-10-years-after-roux-en-y-gastric-bypass
#4
Robert B Hawkins, J Hunter Mehaffey, Timothy L McMurry, Jennifer Kirby, Steven K Malin, Bruce Schirmer, Peter T Hallowell
BACKGROUND: Although Roux-en-Y gastric bypass (RYGB) induces short-term weight loss and co-morbidity amelioration, long-term data suggest that a subset of patients return to their preoperative body mass index (BMI). OBJECTIVES: To identify the clinical implications of 10-year weight loss failure after RYGB. SETTING: An academic teaching hospital. METHODS: Adults undergoing RYGB (1985-2004) were included in this study (n = 1087)...
August 9, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28919093/clip-closure-and-division-instead-of-stapling-for-the-last-small-gastric-bridge-between-gastric-pouch-and-remnant-stomach-in-laparoscopic-roux-en-y-gastric-bypass
#5
Adem Yuksel, Fatih Sumer, Cuneyt Kayaalp
INTRODUCTION: Here, a modification during gastric pouch forming was implemented in laparoscopic Roux-en-Y gastric bypass (LRYGB). We aimed to examine the feasibility of metallic clip closure for the remaining small stomach bridges (<1 cm) between the pouch and the remnant stomach. METHODS: During pouch creation, after the last stapler firing, the remaining small bridge was closed with clips and divided instead of using a new stapler. Metallic clips for this aim were used in 41 of 520 LRYGP between September 2010 and January 2017...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28918470/assessment-of-glucose-regulation-in-pregnancy-after-gastric-bypass-surgery
#6
Christian S Göbl, Latife Bozkurt, Andrea Tura, Michael Leutner, Laura Andrei, Lukas Fahr, Peter Husslein, Wolfgang Eppel, Alexandra Kautzky-Willer
AIMS/HYPOTHESIS: Roux-en-Y gastric bypass (RYGB) surgery is characterised by glycaemic variability. Prospective studies of glucose metabolism in pregnancy after RYGB are not available, therefore this study aimed to evaluate physiological alterations in glucose metabolism in pregnancy following RYGB. METHODS: Sixty-three pregnant women (25 who underwent RYGB, 19 non-operated obese control women and 19 normal weight control women) were included. Frequently sampled 3 h OGTTs and 1 h IVGTTs were performed between 24 and 28 weeks of gestation and, in a subgroup, were repeated at 3-6 months after delivery...
September 16, 2017: Diabetologia
https://www.readbyqxmd.com/read/28917615/comment-on-patients-reasons-for-and-against-undergoing-roux-en-y-gastric-bypass-adjustable-gastric-banding-and-vertical-sleeve-gastrectomy
#7
EDITORIAL
Katherine L Applegate
No abstract text is available yet for this article.
August 26, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28917006/synoptic-operative-reporting-assessing-the-completeness-accuracy-reliability-and-efficiency-of-synoptic-reporting-for-roux-en-y-gastric-bypass
#8
Shannon E Stogryn, Krista Hardy, Michael J Mullan, Jason Park, Christopher Andrew, Ashley Vergis
OBJECTIVE: Synoptic reporting (SR) is one solution to improve the quality of operative reports. However, SR has not been investigated in bariatric surgery despite an identified need by bariatric surgeons. SR for RYGB was developed using quality indicators (QIs) established by a national Delphi process. The objective of this study is to assess the completeness, accuracy, reliability, and efficiency of synoptic versus narrative operative reports (NR) in Roux-en-Y gastric bypass (RYGB). METHODS: A NR and SR were completed on 104 consecutive RYGBs...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28915970/a-new-proposed-mechanism-of-action-for-gastric-bypass-surgery-air-hypothesis
#9
Hasan Celiker
Roux-en-Y gastric bypass (RYGB) surgery is one of the most effective treatments for obesity and type II diabetes. RYGB was originally believed to work by mechanically restricting caloric intake or causing macronutrient malabsorption. However, such mechanical effects play no role in the remarkable efficacy of gastric bypass. Instead, mounting evidence shows that altered neuroendocrine signaling is responsible for the weight reducing effects of RYGB. The exact mechanism of this surgical response is still a mystery...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28913642/small-volume-fast-emptying-gastric-pouch-leads-to-better-long-term-weight-loss-and-food-tolerance-after-roux-en-y-gastric-bypass
#10
Daniel Riccioppo, Marco Aurelio Santo, Manoel Rocha, Carlos Alberto Buchpiguel, Marcio Augusto Diniz, Denis Pajecki, Roberto de Cleva, Flavio Kawamoto
INTRODUCTION: Anatomical and functional influences on gastric bypass (GBP) results are often poorly evaluated and not yet fully understood. PURPOSE: The purpose of this study is to evaluate the influence of the gastric pouch volume and its emptying rate on long-term weight loss and food tolerance after GBP. MATERIALS AND METHODS: Weight loss, food tolerance, pouch volumetry (V) by three-dimensional reconstruction, and pouch emptying rate by 4 h scintigraphy were evaluated in 67 patients...
September 14, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28905292/effects-of-laparoscopic-roux-en-y-gastric-bypass-for-type-2-diabetes-mellitus-comparison-of-bmi-%C3%A2-30-and-%C3%A2-30%C3%A2-kg-m-2
#11
Zhigang Ke, Fan Li, Jing Chen, Yu Gao, Xunmei Zhou, Fang Sun, Chunxue Li, Baohua Liu, Qiang Li, Zhiming Zhu, Weidong Tong
BACKGROUND: Recently, many studies focused on type 2 diabetes mellitus (T2DM) patients with body mass index (BMI) < 30 kg/m(2) and suggested that those patients might benefit from Roux-en-Y gastric bypass (RYGB). However, evidence on its effectiveness to improve T2DM patients with BMI < 30 kg/m(2) is still lacking. The aim of this study is to explore whether T2DM patients with BMI < 30 kg/m(2) get similar surgical effect from RYGB compared with those patients with BMI > 30 kg/m(2)...
September 13, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28895037/management-of-acute-sleeve-gastrectomy-leaks-by-conversion-to-roux-en-y-gastric-bypass-a-small-case-series
#12
Kutay Saglam, Aydin Aktas, Ersin Gundogan, Ismail Ertugrul, Ali Tardu, Servet Karagul, Serdar Kirmizi, Fatih Sumer, Veysel Ersan, Cuneyt Kayaalp
Management of early sleeve gastrectomy leak remains challenging. The recommended approach is endoscopic stenting and abdominal drainage. Conversion to a Roux-en-Y gastric bypass (RYGB) is a common procedure used for late fistulas with distal obstruction. Here, we have presented three cases of early staple line leaks treated by conversion to RYGB. These patients had uncontrolled abdominal infections despite intensive medical treatments, and surgery was elected for abdominal drainage as well as to control the source of sepsis...
September 11, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28894292/partitioning-of-adipose-lipid-metabolism-by-altered-expression-and-function-of-ppar-isoforms-after-bariatric-surgery
#13
C Jahansouz, H Xu, A V Hertzel, S Kizy, K A Steen, R Foncea, F J Serrot, N Kvalheim, G Luthra, K Ewing, D B Leslie, S Ikramuddin, D A Bernlohr
BACKGROUND: Bariatric surgery remains the most effective treatment for reducing adiposity and eliminating type 2 diabetes; however, the mechanism(s) responsible have remained elusive. Peroxisome proliferator-activated receptors (PPAR) encompass a family of nuclear hormone receptors that upon activation exert control of lipid metabolism, glucose regulation and inflammation. Their role in adipose tissue following bariatric surgery remains undefined. MATERIALS AND METHODS: Subcutaneous adipose tissue biopsies and serum were obtained and evaluated from time of surgery and on postoperative day 7 in patients randomized to Roux-en-Y gastric bypass (n=13) or matched caloric restriction (n=14), as well as patients undergoing vertical sleeve gastrectomy (n=33)...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28894289/factors-associated-with-long-term-weight-loss-maintenance-following-bariatric-surgery-in-adolescents-with-severe-obesity
#14
J R Ryder, A C Gross, C K Fox, A M Kaizer, K D Rudser, T M Jenkins, M B Ratcliff, A S Kelly, S Kirk, R M Siegel, T H Inge
BACKGROUND/OBJECTIVES: Bariatric surgery produces robust weight loss, however, factors associated with long-term weight-loss maintenance among adolescents undergoing Roux-en-Y gastric bypass surgery are unknown. SUBJECTS/METHODS: Fifty adolescents (mean±s.d. age and body mass index (BMI)=17.1±1.7 years and 59±11 kg m(-2)) underwent Roux-en-Y gastric bypass surgery, had follow-up visits at 1 year and at a visit between 5 and 12 years following surgery (Follow-up of Adolescent Bariatric Surgery at 5 Plus years (FABS-5+) visit; mean±s...
August 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28892258/sitagliptin-and-roux-en-y-gastric-bypass-modulate-insulin-secretion-via-regulation-of-intra-islet-pyy
#15
Claudia Guida, Laura J McCulloch, Mahdieh Godazgar, Sam D Stephen, Charlotte Baker, Davide Basco, Jiawen Dong, Duan Chen, Anne Clark, Reshma D Ramracheya
AIMS: The gut hormone peptide tyrosine tyrosine (PYY) is critical for maintaining islet integrity and restoring islet function following Roux-en-Y gastric bypass (RYGB). The expression of PYY and its receptors (NPYRs) in islets has been documented but not fully characterized. Modulation of islet PYY by the proteolytic enzyme DPP-IV has not been investigated and the impact of DPP-IV inhibition on islet PYY function remains unexplored. Here we have addressed these gaps and their effects on glucose-stimulated insulin secretion (GSIS)...
September 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28890311/pancreatoduodenectomy-after-roux-en-y-gastric-bypass-technical-considerations-and-outcomes
#16
June S Peng, Ricard Corcelles, Kevin Choong, Matthew Poturalski, Namita Gandhi, R Matthew Walsh, Jeffrey M Hardacre, Stacy A Brethauer, Gareth Morris-Stiff
BACKGROUND: Patients with altered anatomy due to Roux-en-Y gastric bypass (RYGB) present unique diagnostic and therapeutic challenges when they present with periampullary pathology. We describe a series of patients who underwent pancreatoduodenectomy (PD) after gastric surgery with Roux-en-Y reconstruction and review the literature to highlight technical considerations and outcomes. METHODS: Patients from two institutions were identified and data regarding preoperative workup, operative conduct, and pathologic and clinical outcomes were collected...
September 7, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28888796/laparoscopic-treatment-of-gastroparesis-a-single-center-experience
#17
Kotaro Wakamatsu, Federico Perez Quirante, Lisandro Montorfano, Emanuele Lo Menzo, Yasuyuki Seto, Raul J Rosenthal
BACKGROUND: Gastroparesis (GP) is a chronic disorder of gastric motility with delayed gastric emptying. Gastric electrical stimulator (GES) implantation and Roux-en-Y gastric bypass (RYGB) are surgical options for medically refractory GP. OBJECTIVE: Evaluate operational outcomes and symptom improvement of patients with diabetic (DM) and idiopathic (IP) GP. SETTING: University Hospital, United States. METHODS: A retrospective chart review was performed of all patients who underwent surgical treatment of GP from February 2003 to December 2014...
July 29, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28887853/neuroendocrine-mechanisms-underlying-bariatric-surgery-insights-from-human-studies-and-animal-models
#18
REVIEW
Aneta Stefanidis, Brian J Oldfield
Obesity has reached epidemic proportions and to date, bariatric surgery remains the only effective treatment for morbid obesity in terms of its capacity to achieve durable weight loss. Bariatric surgery procedures, including Roux-en-Y gastric bypass (RYGB), adjustable gastric banding (AGB) and sleeve gastrectomy (SG) have been the primary procedures conducted over the past decade, with SG increasing in popularity over the past five years at the expense of both RYGB and AGB. Although these procedures were initially proposed to function via restrictive or malabsorptive mechanisms, it is now clear that profound physiological changes underlie the metabolic improvements in patients who undergo bariatric surgery...
September 8, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28885564/relationship-between-the-nutritional-status-of-vitamin-a-per-trimester-of-pregnancy-with-maternal-anthropometry-and-anemia-after-roux-en-y-gastric-bypass
#19
Sabrina Cruz, Andréa Matos, Suelem Pereira da Cruz, Silvia Pereira, Carlos Saboya, Andréa Ramalho
The aim of this study was to compare the nutritional status of vitamin A per trimester of pregnancy, as well as to assess its influence on pre-pregnancy BMI, total gestational weight gain (TGWG) and presence of anemia in women who had previously undergone Roux-en-Y gastric bypass (RYGB). An analytical, longitudinal and retrospective study comprising 30 pregnant women who had previously undergone RYGB was undertaken. In all trimesters of pregnancy, the serum concentrations of retinol, β-carotene, stages of vitamin A deficiency (VAD), night blindness (NB), anemia and anthropometric variables were assessed...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28884370/diagnosis-of-gastrogastric-fistula-on-computed-tomography-a-quantitative-approach
#20
Guangzu Gao, Nariman Nezami, Mahan Mathur, Patricia Balcacer, Gary Israel, Michael Spektor
OBJECTIVE: To determine if the attenuation of contrast material in the excluded stomach compared with the gastric pouch is helpful in diagnosing gastrogastric (GG) fistula. MATERIALS AND METHODS: In a retrospective study, 13 CT scans in 12 patients (age 43.2 ± 9.2, 10 females) who had undergone Roux-en-Y gastric bypass and who had oral contrast in both the gastric pouch and excluded stomach were qualitatively and quantitatively evaluated for GG fistula by two radiologists, using upper GI series (UGI) as the gold standard...
September 8, 2017: Abdominal Radiology
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