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suppurative arthritis

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https://www.readbyqxmd.com/read/28405135/severe-bone-marrow-suppression-accompanying-pulmonary-infection-and-hemorrhage-of-the-digestive-tract-associated-with-leflunomide-and-low-dose-methotrexate-combination-therapy
#1
Caihong Qu, Ying Lu, Weimin Liu
A 60-year-old male patient developed hyperpyrexia, cough, expectoration with blood-stained sputum, mouth ulcers, and suppurative tonsillitis after receiving 35 days of combination treatment with leflunomide (LEF) and low-dose methotrexate (MTX) for active rheumatoid arthritis. On admission, routine blood tests showed severe thrombocytopenia, agranulocytosis, and decreased hemoglobin concentration compared with the relatively normal results of 1 month previously during the first hospitalization. Chest radiography revealed inflammation in both lungs, and a fecal occult blood test was positive...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28389347/patho-bacteriological-investigation-of-an-outbreak-of-mycoplasma-bovis-infection-in-calves-emerging-stealth-assault
#2
Fazal Mahmood, Ahrar Khan, Riaz Hussain, Imtiaz Ahmad Khan, Rao Zahid Abbas, Hafiz Muhammad Ali, Muhammad Younus
Mycoplasma bovis (M. bovis) is an important bacterium, causing severe respiratory infection, and arthritis in dairy animals worldwide. This study is based on 50 suckling calves among which 15 showed respiratory distress, lameness and swollen joints and died later. M. bovis was isolated and identified from all dead (n = 15) and live (17.14%; 06 out of 35) calves on the basis of bacteriological examination. In morbid calves, the carpus and stifle joints were severely affected, while necropsy revealed multiple well-circumscribed calcified abscesses and caseous exudates in cranio-ventral and diaphragmatic lobes of lungs...
April 4, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28274350/difficult-and-rare-forms-of-acne
#3
Clio Dessinioti, Andreas Katsambas
Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acneiform disease that clinically mimics acne, thus misleading the clinician, if not ruled out, with scrutiny. Difficulties in the management of acne may be attributable to patient-related issues (low adherence to treatment or fear for side effects), treatment-related issues (inappropriate treatment, dose, or duration of treatment), or difficult-to-treat acne types (acne conglobata or acne fulminans)...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28255484/surgical-management-of-multijoint-septic-arthritis-due-to-rat-bite-fever-in-a-pediatric-patient-a-case-study
#4
Adam M Wegner, Nicole Look, Brian M Haus
In the United States, rat-bite fever is a rare systemic illness principally caused by Streptobacillus moniliformis, an organism found in the nasopharyngeal flora of rodents. Infection through direct exposure to rat excreta such as saliva, urine, or feces can lead to fever, rash, and an asymmetric migratory polyarthritis. As rodents are becoming more popular as pets, more pediatric cases are being documented. We report a pediatric case of delayed onset septic arthritis in the left wrist and right knee due to S...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28236224/papa-pash-and-papash-syndromes-pathophysiology-presentation-and-treatment
#5
REVIEW
Massimo Cugno, Alessandro Borghi, Angelo V Marzano
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis usually manifesting as skin ulcers with undermined erythematous-violaceous borders. It may be isolated, associated with systemic conditions or occurring in the context of autoinflammatory syndromes such as PAPA (pyogenic arthritis, PG and acne), PASH (PG, acne and suppurative hidradenitis) or PAPASH (pyogenic arthritis, acne, PG and suppurative hidradenitis). From a physiopathological point of view, all these conditions share common mechanisms consisting of over-activation of the innate immune system leading to increased production of the interleukin (IL)-1 family and 'sterile' neutrophil-rich cutaneous inflammation...
February 25, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28210926/a-fatal-suppurative-pneumonia-in-piglets-caused-by-a-pathogenic-coagulase-positive-strain-of-staphylococcus-hyicus
#6
Mingyue Wang, Junying Hu, Lisai Zhu, Chunguang Guo, Haibing Lu, Changming Guo, Xin Li, Xinping Wang
Staphylococcus hyicus is one of the opportunistic pathogens that cause infections to animals. Early studies have demonstrated that S. hyicus is the causative agents of exudative epidermitis in pigs, arthritis in horses and chicken, mastitis in cow, and bacteremia, sepsis and multiple organ failure in humans. Here, we report the isolation and identification of a representative S. hyicus isolate, named JLHN15, from a pig farm with a disease characterized by bacteremia, suppurative pneumonia and fibrinous pericarditis...
February 16, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28108382/new-xanthones-and-cytotoxic-constituents-from-garcinia-mangostana-fruit-hulls-against-human-hepatocellular-breast-and-colorectal-cancer-cell-lines
#7
Gamal A Mohamed, Ahmed M Al-Abd, Ali M El-Halawany, Hossam M Abdallah, Sabrin R M Ibrahim
ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer...
January 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27977547/erysipelothrix-rhusiopathiae-suppurative-arthritis-in-a-12-year-old-boy-after-an-unusual-fresh-water-exposure
#8
Laila S Alawdah, Jaime N Campbell, Nira Pollock, Paula I Watnick
We report the case of a 12-year-old boy who experienced recurrent suppurative arthritis of the distal interphalangeal joint after near simultaneous exposure to a frog, a dog bite and lake water. Anaerobic cultures of synovial fluid obtained during operative debridement grew small round gray colonies ultimately identified as Erysipelothrix rhusiopathiae by routine laboratory tests and mass spectrometry.
April 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27793205/measurement-of-serum-c-reactive-protein-concentration-for-discriminating-between-suppurative-arthritis-and-osteoarthritis-in-dogs
#9
Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall, Mads Kjelgaard-Hansen
BACKGROUND: In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27622687/group-a-streptococcal-suppurative-arthritis-and-osteomyelitis-of-the-shoulder-with-brachial-plexus-palsy-in-a-newborn
#10
Alexa Dierig, Nicole Ritz, Uta Tacke, Ulrich Heininger
Osteoarticular infections in the newborn period are rare. A serious complication is paralysis of the affected extremity resulting from either pain or direct involvement of the nerve. We report a newborn with combined osteomyelitis and suppurative arthritis caused by Streptococcus pyogenes presenting with right brachial plexus palsy.
October 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27530224/pyogenic-arthritis-pyoderma-gangrenosum-acne-suppurative-hidradenitis-pa-pash-syndrome-an-atypical-presentation-of-a-rare-syndrome
#11
Mohammad A Ursani, Joan Appleyard, Onome Whiteru
BACKGROUND Pyogenic arthritis, pyoderma gangrenosum (PG), acne, and suppurative hidradenitis (PA-PASH) syndrome has been linked to an auto-inflammatory pathway. We report a case that is an atypical presentation of a rare syndrome, which supports literature suggesting that different phenotypes of PG-related syndromes may be a variation of the same pathogenic spectrum. Interestingly, our patient displayed a positive proteinase-3 antibody (PR-3). The clinical relevance of this is unclear. In recent literature, antineutrophil cytoplasmic autoantibodies (ANCA) positivity has been reported in various inflammatory conditions other than ANCA-associated vasculitis (AAV)...
August 17, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27448064/-severe-acne-in-autoinflammatory-diseases
#12
S Faleri, K Feichtner, T Ruzicka
BACKGROUND: In recent years, acne has been described as a symptom of autoinflammatory diseases, such as PASH (pyoderma gangrenosum - PG, acne and suppurative hidradenitis - SH) and PAPASH (PG, acne, pyogenic arthritis, and SH). The pathogenesis of autoinflammatory diseases is not fully understood; however, based on the possible involvement of IL-1β, the recombinant human interleukin-1 receptor antagonist anakinra has been used in the treatment of certain autoinflammatory diseases. METHODS: We describe two patients with severe acne and associated symptoms which led to the diagnosis PAPASH and PASH syndrome and who were treated with anakinra...
November 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27287745/subcutaneous-phaeohyphomycosis-caused-by-pyrenochaeta-romeroi-in-a-rheumatoid-arthritis-patient-a-case-report-with-review-of-the-literature
#13
REVIEW
Sonam Sharma, Malini R Capoor, Mukul Singh, Deepti Kiran, Ashish Kumar Mandal
Pyrenochaeta romeroi is a rare fungal agent of chronic, suppurative subcutaneous infections leading to mycetoma. It is an unusual cause of deep, non-mycetomatous infections. We herein present review of the literature along with a case of 61-year-old Indian female with rheumatoid arthritis who developed subcutaneous phaeohyphomycosis caused by Pyrenochaeta romeroi. It posed a diagnostic challenge, as the culture from fine-needle aspirate revealed a non-sporulating dematiaceous mould, which was the only supportive tool for its diagnosis and initiation of the therapy...
October 2016: Mycopathologia
https://www.readbyqxmd.com/read/27106250/pyoderma-gangrenosum-and-its-syndromic-forms-evidence-for-a-link-with-autoinflammation
#14
REVIEW
A V Marzano, A Borghi, P L Meroni, M Cugno
Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells...
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27010465/periventricular-leukomalacia-in-a-neonatal-calf
#15
Kenji Koyama, Riku Fujita, Masaki Maezawa, Natsuko Fukumoto, Noriyuki Horiuchi, Hisashi Inokuma, Yoshiyasu Kobayashi
A 10-day-old, Japanese Black, female calf had shown astasia since just after birth. Focal symmetrical periventricular malacic lesions of the cerebrum and suppurative arthritis of the left hip joint were observed in macroscopic examination. Histologically, the cerebral lesions were confirmed as periventricular leukomalacia (PVL). The location and histological features of the lesions were similar to PVL in humans, caused by neonatal ischemia/hypovolemia. This is the first report of PVL in a neonatal calf.
August 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26865172/chronic-granulomatous-disease
#16
REVIEW
Amit Rawat, Sagar Bhattad, Surjit Singh
Chronic granulomatous disease (CGD) is the most common symptomatic phagocytic defect. It is caused by mutations in genes encoding protein subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. CGD is characterized by a defective intracellular killing of phagocytosed organisms due to a defective oxidative burst in the neutrophils and macrophages. It is inherited in either X-linked recessive or autosomal recessive pattern. Staphylococcus aureus and Aspergillus species are the most common organisms reported...
April 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26477152/-research-of-acetabular-orientation-determination-and-accuracy-in-total-hip-arthroplasty-for-bony-ankylosed-hip
#17
Yingxu Fu, Desheng Yang, Asihaerjiang-Maimaitiyiming, Li Cao, Wentao Guo
OBJECTIVE: To explore the method of acetabular orientation determination in total hip arthroplasty (THA) for bony ankylosed hip and the accuracy of the postoperative evaluation. METHODS: Between January 2009 and March 2013, 33 consecutive patients (49 hips) underwent THA. There were 25 males and 8 females with a mean age of 35.8 years (range, 18-69 years). The left hip was involved in 10 cases, the right hip in 7 cases, and bilateral hips in 16 cases. The causes were ankylosing spondylitis in 18 patients, tuberculosis in 6 patients, traumatic arthritis in 6 patients, osteoarthritis in 2 patients, and suppurative infection in 1 patient...
April 2015: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/26455187/-clinical-results-of-uncemented-total-hip-arthroplasty-for-ultimate-hip-disease-combined-with-proximal-femoral-deformity
#18
Zhenjun You, Junying Sun, Guochun Zha, Tao Wang, Shengjie Dong, Tao Jiang
OBJECTIVE: To evaluate the clinical results of uncemented total hip arthroplasty (THA) for ultimate hip disease combined with proximal femoral deformity. METHODS: Between February 2005 and June 2013, 48 cases (51 hips) of ultimate hip disease combined with proximal femoral deformity were treated with uncemented THA and osteotomy. There were 14 males (16 hips) and 34 females (35 hips), with an average age of 52 years (range, 19-83 years). Unilateral hip was involved in 45 cases, and bilateral hips in 3 cases...
March 2015: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/26135866/phaeohyphomycosis-caused-by-a-novel-species-pseudochaetosphaeronema-martinelli
#19
Sarah A Ahmed, Nicole Desbois, D Quist, C Miossec, Carlos Atoche, Alexandro Bonifaz, G Sybren de Hoog
Among the opportunistic mycoses that are emerging in patients with immunosuppression or severe underlying illness, many isolates lack of characteristic sporulation and until recently could not be identified. Clinical signs are mostly nonspecific and therefore such infections have often been disregarded. In the present paper we describe a novel, nonsporulating fungal species causing subcutaneous phaeohyphomycosis in two patients of different origin. One is a 73-year-old female from Martinique who suffered from rheumatoid arthritis, while the other case concerns a 72-year-old male from Mexico who had a history of type 2 diabetes mellitus...
September 2015: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26051917/consensus-statement-on-surgical-pathology-of-the-aorta-from-the-society-for-cardiovascular-pathology-and-the-association-for-european-cardiovascular-pathology-i-inflammatory-diseases
#20
REVIEW
James R Stone, Patrick Bruneval, Annalisa Angelini, Giovanni Bartoloni, Cristina Basso, Lubov Batoroeva, L Maximilian Buja, Jagdish Butany, Giulia d'Amati, John T Fallon, Adriana C Gittenberger-de Groot, Rosa H Gouveia, Marc K Halushka, Karen L Kelly, Ivana Kholova, Ornella Leone, Silvio H Litovsky, Joseph J Maleszewski, Dylan V Miller, Richard N Mitchell, Stephen D Preston, Angela Pucci, Stanley J Radio, E Rene Rodriguez, Mary N Sheppard, S Kim Suvarna, Carmela D Tan, Gaetano Thiene, Allard C van der Wal, John P Veinot
Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and atherosclerosis with excessive inflammatory responses, such as inflammatory atherosclerotic aneurysms. The nomenclature and histologic features of these disorders are reviewed and discussed. In addition, diagnostic criteria are provided to distinguish between these disorders in surgical pathology specimens. An initial classification scheme is provided for aortitis and periaortitis based on the pattern of the inflammatory infiltrate: granulomatous/giant cell pattern, lymphoplasmacytic pattern, mixed inflammatory pattern, and the suppurative pattern...
September 2015: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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