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https://www.readbyqxmd.com/read/29402745/design-synthesis-and-antibacterial-evaluation-of-honokiol-derivatives
#1
Bo Wu, Su-Hong Fu, Huan Tang, Kai Chen, Qiang Zhang, Ai-Hua Peng, Hao-Yu Ye, Xing-Jun Cheng, Mao Lian, Zhen-Ling Wang, Li-Juan Chen
Staphylococcus aureus is a major and dangerous human pathogen that causes a range of clinical manifestations of varying severity, and is the most commonly isolated pathogen in the setting of skin and soft tissue infections, pneumonia, suppurative arthritis, endovascular infections, foreign-body associated infections, septicemia, osteomyelitis, and toxic shocksyndrome. Honokiol, a pharmacologically active natural compound derived from the bark of Magnolia officinalis, has antibacterial activity against Staphylococcus aureus which provides a great inspiration for the discovery of potential antibacterial agents...
February 15, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29349976/-analysis-on-the-arthroscopy-efficacy-with-different-irrigation-times-for-the-treatment-of-suppurative-knee-arthritis-in-elder-patients
#2
Yi Yuan, Hai-Jun Zhang, Bo Zhang, Hao Luo, Chao Yang
OBJECTIVE: To evaluate the curative effect of arthroscopy-assisted irrigation with different times for the treatment of suppurative knee arthritis in elder patients. METHODS: From October 2012 to October 2014, 23 old patients with suppurative knee arthritis were treated with arthroscopic debridement and continuous irrigation. All the patients were randomly divided into two groups:one-week irrigation group (10 cases) and two-week irrigation group(13 cases). The ESR, CRP, recovery time of knee skin temperature, joint rang of motion and knee function were observed to evaluate the therapeutic effects...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29284213/pathologic-and-molecular-characterization-of-streptococcus-dysgalactiae-subsp-equisimilis-infection-in-neonatal-piglets
#3
Sang-Ik Oh, Jong Wan Kim, Ji-Youl Jung, Myeongju Chae, Yu-Ran Lee, Jong Ho Kim, ByungJae So, Ha-Young Kim
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is an emerging pathogen in animals and humans. Herein, we describe two clinical swine cases of SDSE infection presenting with lameness, neurological signs, or sudden death. Pathological examination indicated suppurative arthritis, encephalitis, and multifocal abscesses in kidney and heart. The β-hemolytic colonies obtained from joint samples of each case were identified as SDSE. The two isolates had low minimum inhibitory concentrations for β-lactams, and they presented the same virulence gene profile ( slo - / sagA + /pSTKP8+ )...
March 31, 2018: Journal of Veterinary Science
https://www.readbyqxmd.com/read/29221920/treatment-of-infected-aneurysm-with-combined-endovascular-aneurysm-repair-and-abscess-drainage
#4
Ken Nakajima, Noriyuki Kato, Takashi Hashimoto, Shuji Chino, Takatoshi Higashigawa, Takafumi Ouchi, Toshiya Tokui, Yoichiro Miyake, Hajime Sakuma
PURPOSE: To evaluate the clinical utility of combination therapy with endovascular aneurysm repair (EVAR) and abscess drainage for the treatment of infected aneurysms. MATERIALS AND METHODS: Between July 2009 and May 2015, 8 patients underwent combination therapy with EVAR and abscess drainage. There were 5 men and 3 women, with a mean age of 75 years ± 7. Aneurysms were of the thoracic aorta in 5 patients, the abdominal aorta in 2, and the internal iliac artery in 1...
February 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28550986/acute-deep-infections-of-the-upper-extremity-the-utility-of-obtaining-atypical-cultures-in-the-presence-of-purulence
#5
Nikolas H Kazmers, George W Fryhofer, Daniel Gittings, David J Bozentka, David R Steinberg, Benjamin L Gray
PURPOSE: In the setting of acute deep upper extremity infections, evidence is lacking to guide the decision whether to send atypical cultures (fungal and acid-fast-bacillus [AFB]) during surgical debridement, especially in the presence of purulent fluid that is commonly observed with typical bacterial infections. Our purpose was to determine the frequency of positive atypical cultures and the frequency with which they alter treatment, and identify factors associated with positive atypical cultures...
August 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28405135/severe-bone-marrow-suppression-accompanying-pulmonary-infection-and-hemorrhage-of-the-digestive-tract-associated-with-leflunomide-and-low-dose-methotrexate-combination-therapy
#6
Caihong Qu, Ying Lu, Weimin Liu
A 60-year-old male patient developed hyperpyrexia, cough, expectoration with blood-stained sputum, mouth ulcers, and suppurative tonsillitis after receiving 35 days of combination treatment with leflunomide (LEF) and low-dose methotrexate (MTX) for active rheumatoid arthritis. On admission, routine blood tests showed severe thrombocytopenia, agranulocytosis, and decreased hemoglobin concentration compared with the relatively normal results of 1 month previously during the first hospitalization. Chest radiography revealed inflammation in both lungs, and a fecal occult blood test was positive...
January 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28389347/patho-bacteriological-investigation-of-an-outbreak-of-mycoplasma-bovis-infection-in-calves-emerging-stealth-assault
#7
Fazal Mahmood, Ahrar Khan, Riaz Hussain, Imtiaz Ahmad Khan, Rao Zahid Abbas, Hafiz Muhammad Ali, Muhammad Younus
Mycoplasma bovis (M. bovis) is an important bacterium, causing severe respiratory infection, and arthritis in dairy animals worldwide. This study is based on 50 suckling calves among which 15 showed respiratory distress, lameness and swollen joints and died later. M. bovis was isolated and identified from all dead (n = 15) and live (17.14%; 06 out of 35) calves on the basis of bacteriological examination. In morbid calves, the carpus and stifle joints were severely affected, while necropsy revealed multiple well-circumscribed calcified abscesses and caseous exudates in cranio-ventral and diaphragmatic lobes of lungs...
June 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28274350/difficult-and-rare-forms-of-acne
#8
Clio Dessinioti, Andreas Katsambas
Acne is the most common of skin diseases, being characterized as a chronic inflammatory disease of the pilosebaceous unit. Although acne is usually straightforward to diagnose and treat, some patients have difficult or rare forms of acne. What seems to be "nonresponding acne" in a patient may be caused by another acneiform disease that clinically mimics acne, thus misleading the clinician, if not ruled out, with scrutiny. Difficulties in the management of acne may be attributable to patient-related issues (low adherence to treatment or fear for side effects), treatment-related issues (inappropriate treatment, dose, or duration of treatment), or difficult-to-treat acne types (acne conglobata or acne fulminans)...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28255484/surgical-management-of-multijoint-septic-arthritis-due-to-rat-bite-fever-in-a-pediatric-patient-a-case-study
#9
Adam M Wegner, Nicole Look, Brian M Haus
In the United States, rat-bite fever is a rare systemic illness principally caused by Streptobacillus moniliformis, an organism found in the nasopharyngeal flora of rodents. Infection through direct exposure to rat excreta such as saliva, urine, or feces can lead to fever, rash, and an asymmetric migratory polyarthritis. As rodents are becoming more popular as pets, more pediatric cases are being documented. We report a pediatric case of delayed onset septic arthritis in the left wrist and right knee due to S...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28236224/papa-pash-and-papash-syndromes-pathophysiology-presentation-and-treatment
#10
REVIEW
Massimo Cugno, Alessandro Borghi, Angelo V Marzano
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis usually manifesting as skin ulcers with undermined erythematous-violaceous borders. It may be isolated, associated with systemic conditions or occurring in the context of autoinflammatory syndromes such as PAPA (pyogenic arthritis, PG and acne), PASH (PG, acne and suppurative hidradenitis) or PAPASH (pyogenic arthritis, acne, PG and suppurative hidradenitis). From a physiopathological point of view, all these conditions share common mechanisms consisting of over-activation of the innate immune system leading to increased production of the interleukin (IL)-1 family and 'sterile' neutrophil-rich cutaneous inflammation...
August 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28210926/a-fatal-suppurative-pneumonia-in-piglets-caused-by-a-pathogenic-coagulase-positive-strain-of-staphylococcus-hyicus
#11
Mingyue Wang, Junying Hu, Lisai Zhu, Chunguang Guo, Haibing Lu, Changming Guo, Xin Li, Xinping Wang
Staphylococcus hyicus is one of the opportunistic pathogens that cause infections to animals. Early studies have demonstrated that S. hyicus is the causative agents of exudative epidermitis in pigs, arthritis in horses and chicken, mastitis in cow, and bacteremia, sepsis and multiple organ failure in humans. Here, we report the isolation and identification of a representative S. hyicus isolate, named JLHN15, from a pig farm with a disease characterized by bacteremia, suppurative pneumonia and fibrinous pericarditis...
June 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28108382/new-xanthones-and-cytotoxic-constituents-from-garcinia-mangostana-fruit-hulls-against-human-hepatocellular-breast-and-colorectal-cancer-cell-lines
#12
Gamal A Mohamed, Ahmed M Al-Abd, Ali M El-Halawany, Hossam M Abdallah, Sabrin R M Ibrahim
ETHNOPHARMACOLOGICAL RELEVANCE: Cancer has proceeded to surpass one of the most chronic illnesses to be the major cause of mortality in both the developing and developed world. Garcinia mangostana L. (mangosteen, family Guttiferae) known as the queen of fruits, is one of the most popular tropical fruits. It is cultivated in Southeast Asian countries: Malaysia, Indonesia, Sri Lanka, Burma, Thailand, and Philippines. Traditionally, numerous parts of G. mangostana have been utilized to treat various ailments such as abdominal pain, haemorrhoids, food allergies, arthritis, leucorrhoea, gonorrhea, diarrhea, dysentery, wound infection, suppuration, and chronic ulcer...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27977547/erysipelothrix-rhusiopathiae-suppurative-arthritis-in-a-12-year-old-boy-after-an-unusual-fresh-water-exposure
#13
Laila S Alawdah, Jaime N Campbell, Nira Pollock, Paula I Watnick
We report the case of a 12-year-old boy who experienced recurrent suppurative arthritis of the distal interphalangeal joint after near simultaneous exposure to a frog, a dog bite and lake water. Anaerobic cultures of synovial fluid obtained during operative debridement grew small round gray colonies ultimately identified as Erysipelothrix rhusiopathiae by routine laboratory tests and mass spectrometry.
April 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27793205/measurement-of-serum-c-reactive-protein-concentration-for-discriminating-between-suppurative-arthritis-and-osteoarthritis-in-dogs
#14
Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall, Mads Kjelgaard-Hansen
BACKGROUND: In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27622687/group-a-streptococcal-suppurative-arthritis-and-osteomyelitis-of-the-shoulder-with-brachial-plexus-palsy-in-a-newborn
#15
Alexa Dierig, Nicole Ritz, Uta Tacke, Ulrich Heininger
Osteoarticular infections in the newborn period are rare. A serious complication is paralysis of the affected extremity resulting from either pain or direct involvement of the nerve. We report a newborn with combined osteomyelitis and suppurative arthritis caused by Streptococcus pyogenes presenting with right brachial plexus palsy.
October 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27530224/pyogenic-arthritis-pyoderma-gangrenosum-acne-suppurative-hidradenitis-pa-pash-syndrome-an-atypical-presentation-of-a-rare-syndrome
#16
Mohammad A Ursani, Joan Appleyard, Onome Whiteru
BACKGROUND Pyogenic arthritis, pyoderma gangrenosum (PG), acne, and suppurative hidradenitis (PA-PASH) syndrome has been linked to an auto-inflammatory pathway. We report a case that is an atypical presentation of a rare syndrome, which supports literature suggesting that different phenotypes of PG-related syndromes may be a variation of the same pathogenic spectrum. Interestingly, our patient displayed a positive proteinase-3 antibody (PR-3). The clinical relevance of this is unclear. In recent literature, antineutrophil cytoplasmic autoantibodies (ANCA) positivity has been reported in various inflammatory conditions other than ANCA-associated vasculitis (AAV)...
August 17, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27448064/-severe-acne-in-autoinflammatory-diseases
#17
S Faleri, K Feichtner, T Ruzicka
BACKGROUND: In recent years, acne has been described as a symptom of autoinflammatory diseases, such as PASH (pyoderma gangrenosum - PG, acne and suppurative hidradenitis - SH) and PAPASH (PG, acne, pyogenic arthritis, and SH). The pathogenesis of autoinflammatory diseases is not fully understood; however, based on the possible involvement of IL-1β, the recombinant human interleukin-1 receptor antagonist anakinra has been used in the treatment of certain autoinflammatory diseases. METHODS: We describe two patients with severe acne and associated symptoms which led to the diagnosis PAPASH and PASH syndrome and who were treated with anakinra...
November 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27287745/subcutaneous-phaeohyphomycosis-caused-by-pyrenochaeta-romeroi-in-a-rheumatoid-arthritis-patient-a-case-report-with-review-of-the-literature
#18
REVIEW
Sonam Sharma, Malini R Capoor, Mukul Singh, Deepti Kiran, Ashish Kumar Mandal
Pyrenochaeta romeroi is a rare fungal agent of chronic, suppurative subcutaneous infections leading to mycetoma. It is an unusual cause of deep, non-mycetomatous infections. We herein present review of the literature along with a case of 61-year-old Indian female with rheumatoid arthritis who developed subcutaneous phaeohyphomycosis caused by Pyrenochaeta romeroi. It posed a diagnostic challenge, as the culture from fine-needle aspirate revealed a non-sporulating dematiaceous mould, which was the only supportive tool for its diagnosis and initiation of the therapy...
October 2016: Mycopathologia
https://www.readbyqxmd.com/read/27106250/pyoderma-gangrenosum-and-its-syndromic-forms-evidence-for-a-link-with-autoinflammation
#19
REVIEW
A V Marzano, A Borghi, P L Meroni, M Cugno
Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells...
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27010465/periventricular-leukomalacia-in-a-neonatal-calf
#20
Kenji Koyama, Riku Fujita, Masaki Maezawa, Natsuko Fukumoto, Noriyuki Horiuchi, Hisashi Inokuma, Yoshiyasu Kobayashi
A 10-day-old, Japanese Black, female calf had shown astasia since just after birth. Focal symmetrical periventricular malacic lesions of the cerebrum and suppurative arthritis of the left hip joint were observed in macroscopic examination. Histologically, the cerebral lesions were confirmed as periventricular leukomalacia (PVL). The location and histological features of the lesions were similar to PVL in humans, caused by neonatal ischemia/hypovolemia. This is the first report of PVL in a neonatal calf.
August 1, 2016: Journal of Veterinary Medical Science
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