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https://www.readbyqxmd.com/read/27793205/measurement-of-serum-c-reactive-protein-concentration-for-discriminating-between-suppurative-arthritis-and-osteoarthritis-in-dogs
#1
Anna Hillström, Jonas Bylin, Ragnvi Hagman, Karin Björhall, Harold Tvedten, Kristian Königsson, Tove Fall, Mads Kjelgaard-Hansen
BACKGROUND: In a dog with joint pain, it is important to determine whether it has suppurative joint disease, characterized by exudation of neutrophils in the synovial fluid, or not, as this affects choice of diagnostic tests and treatments. The aim of this study was to evaluate whether measurement of serum C-reactive protein (CRP) concentration could be used to discriminate between dogs with suppurative arthritis and osteoarthritis (OA). Furthermore, the concentrations of serum and synovial fluid interleukin (IL) 6 concentrations were measured in dogs with joint disease and in healthy dogs, and were correlated to serum CRP concentrations...
October 28, 2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/27622687/group-a-streptococcal-suppurative-arthritis-and-osteomyelitis-of-the-shoulder-with-brachial-plexus-palsy-in-a-newborn
#2
Alexa Dierig, Nicole Ritz, Uta Tacke, Ulrich Heininger
Osteoarticular infections in the newborn period are rare. A serious complication is paralysis of the affected extremity resulting from either pain or direct involvement of the nerve. We report a newborn with combined osteomyelitis and suppurative arthritis caused by Streptococcus pyogenes presenting with right brachial plexus palsy.
October 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27530224/pyogenic-arthritis-pyoderma-gangrenosum-acne-suppurative-hidradenitis-pa-pash-syndrome-an-atypical-presentation-of-a-rare-syndrome
#3
Mohammad A Ursani, Joan Appleyard, Onome Whiteru
BACKGROUND Pyogenic arthritis, pyoderma gangrenosum (PG), acne, and suppurative hidradenitis (PA-PASH) syndrome has been linked to an auto-inflammatory pathway. We report a case that is an atypical presentation of a rare syndrome, which supports literature suggesting that different phenotypes of PG-related syndromes may be a variation of the same pathogenic spectrum. Interestingly, our patient displayed a positive proteinase-3 antibody (PR-3). The clinical relevance of this is unclear. In recent literature, antineutrophil cytoplasmic autoantibodies (ANCA) positivity has been reported in various inflammatory conditions other than ANCA-associated vasculitis (AAV)...
2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27448064/-severe-acne-in-autoinflammatory-diseases
#4
S Faleri, K Feichtner, T Ruzicka
BACKGROUND: In recent years, acne has been described as a symptom of autoinflammatory diseases, such as PASH (pyoderma gangrenosum - PG, acne and suppurative hidradenitis - SH) and PAPASH (PG, acne, pyogenic arthritis, and SH). The pathogenesis of autoinflammatory diseases is not fully understood; however, based on the possible involvement of IL-1β, the recombinant human interleukin-1 receptor antagonist anakinra has been used in the treatment of certain autoinflammatory diseases. METHODS: We describe two patients with severe acne and associated symptoms which led to the diagnosis PAPASH and PASH syndrome and who were treated with anakinra...
July 22, 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27287745/subcutaneous-phaeohyphomycosis-caused-by-pyrenochaeta-romeroi-in-a-rheumatoid-arthritis-patient-a-case-report-with-review-of-the-literature
#5
Sonam Sharma, Malini R Capoor, Mukul Singh, Deepti Kiran, Ashish Kumar Mandal
Pyrenochaeta romeroi is a rare fungal agent of chronic, suppurative subcutaneous infections leading to mycetoma. It is an unusual cause of deep, non-mycetomatous infections. We herein present review of the literature along with a case of 61-year-old Indian female with rheumatoid arthritis who developed subcutaneous phaeohyphomycosis caused by Pyrenochaeta romeroi. It posed a diagnostic challenge, as the culture from fine-needle aspirate revealed a non-sporulating dematiaceous mould, which was the only supportive tool for its diagnosis and initiation of the therapy...
October 2016: Mycopathologia
https://www.readbyqxmd.com/read/27106250/pyoderma-gangrenosum-and-its-syndromic-forms-evidence-for-a-link-with-autoinflammation
#6
REVIEW
A V Marzano, A Borghi, P L Meroni, M Cugno
Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells...
November 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27010465/periventricular-leukomalacia-in-a-neonatal-calf
#7
Kenji Koyama, Riku Fujita, Masaki Maezawa, Natsuko Fukumoto, Noriyuki Horiuchi, Hisashi Inokuma, Yoshiyasu Kobayashi
A 10-day-old, Japanese Black, female calf had shown astasia since just after birth. Focal symmetrical periventricular malacic lesions of the cerebrum and suppurative arthritis of the left hip joint were observed in macroscopic examination. Histologically, the cerebral lesions were confirmed as periventricular leukomalacia (PVL). The location and histological features of the lesions were similar to PVL in humans, caused by neonatal ischemia/hypovolemia. This is the first report of PVL in a neonatal calf.
August 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26865172/chronic-granulomatous-disease
#8
REVIEW
Amit Rawat, Sagar Bhattad, Surjit Singh
Chronic granulomatous disease (CGD) is the most common symptomatic phagocytic defect. It is caused by mutations in genes encoding protein subunits of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. CGD is characterized by a defective intracellular killing of phagocytosed organisms due to a defective oxidative burst in the neutrophils and macrophages. It is inherited in either X-linked recessive or autosomal recessive pattern. Staphylococcus aureus and Aspergillus species are the most common organisms reported...
April 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26477152/-research-of-acetabular-orientation-determination-and-accuracy-in-total-hip-arthroplasty-for-bony-ankylosed-hip
#9
Yingxu Fu, Desheng Yang, Asihaerjiang-Maimaitiyiming, Li Cao, Wentao Guo
OBJECTIVE: To explore the method of acetabular orientation determination in total hip arthroplasty (THA) for bony ankylosed hip and the accuracy of the postoperative evaluation. METHODS: Between January 2009 and March 2013, 33 consecutive patients (49 hips) underwent THA. There were 25 males and 8 females with a mean age of 35.8 years (range, 18-69 years). The left hip was involved in 10 cases, the right hip in 7 cases, and bilateral hips in 16 cases. The causes were ankylosing spondylitis in 18 patients, tuberculosis in 6 patients, traumatic arthritis in 6 patients, osteoarthritis in 2 patients, and suppurative infection in 1 patient...
April 2015: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/26455187/-clinical-results-of-uncemented-total-hip-arthroplasty-for-ultimate-hip-disease-combined-with-proximal-femoral-deformity
#10
Zhenjun You, Junying Sun, Guochun Zha, Tao Wang, Shengjie Dong, Tao Jiang
OBJECTIVE: To evaluate the clinical results of uncemented total hip arthroplasty (THA) for ultimate hip disease combined with proximal femoral deformity. METHODS: Between February 2005 and June 2013, 48 cases (51 hips) of ultimate hip disease combined with proximal femoral deformity were treated with uncemented THA and osteotomy. There were 14 males (16 hips) and 34 females (35 hips), with an average age of 52 years (range, 19-83 years). Unilateral hip was involved in 45 cases, and bilateral hips in 3 cases...
March 2015: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/26135866/phaeohyphomycosis-caused-by-a-novel-species-pseudochaetosphaeronema-martinelli
#11
Sarah A Ahmed, Nicole Desbois, D Quist, C Miossec, Carlos Atoche, Alexandro Bonifaz, G Sybren de Hoog
Among the opportunistic mycoses that are emerging in patients with immunosuppression or severe underlying illness, many isolates lack of characteristic sporulation and until recently could not be identified. Clinical signs are mostly nonspecific and therefore such infections have often been disregarded. In the present paper we describe a novel, nonsporulating fungal species causing subcutaneous phaeohyphomycosis in two patients of different origin. One is a 73-year-old female from Martinique who suffered from rheumatoid arthritis, while the other case concerns a 72-year-old male from Mexico who had a history of type 2 diabetes mellitus...
September 2015: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/26051917/consensus-statement-on-surgical-pathology-of-the-aorta-from-the-society-for-cardiovascular-pathology-and-the-association-for-european-cardiovascular-pathology-i-inflammatory-diseases
#12
REVIEW
James R Stone, Patrick Bruneval, Annalisa Angelini, Giovanni Bartoloni, Cristina Basso, Lubov Batoroeva, L Maximilian Buja, Jagdish Butany, Giulia d'Amati, John T Fallon, Adriana C Gittenberger-de Groot, Rosa H Gouveia, Marc K Halushka, Karen L Kelly, Ivana Kholova, Ornella Leone, Silvio H Litovsky, Joseph J Maleszewski, Dylan V Miller, Richard N Mitchell, Stephen D Preston, Angela Pucci, Stanley J Radio, E Rene Rodriguez, Mary N Sheppard, S Kim Suvarna, Carmela D Tan, Gaetano Thiene, Allard C van der Wal, John P Veinot
Inflammatory diseases of the aorta include routine atherosclerosis, aortitis, periaortitis, and atherosclerosis with excessive inflammatory responses, such as inflammatory atherosclerotic aneurysms. The nomenclature and histologic features of these disorders are reviewed and discussed. In addition, diagnostic criteria are provided to distinguish between these disorders in surgical pathology specimens. An initial classification scheme is provided for aortitis and periaortitis based on the pattern of the inflammatory infiltrate: granulomatous/giant cell pattern, lymphoplasmacytic pattern, mixed inflammatory pattern, and the suppurative pattern...
September 2015: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/25960155/acute-suppurative-oligoarthritis-and-osteomyelitis-a-differential-diagnosis-that-overlaps-with-acute-rheumatic-fever
#13
Satoshi Sato, Masako Chiyotanda, Tae Hijikata, Yu Ishida, Shingo Oana, Gaku Yamanaka, Hisashi Kawashima, Kosuke Kubo
BACKGROUND: Acute rheumatic fever (ARF) is an illness caused by group A streptococcus (GAS) infection, and remains the leading cause of acquired heart disease in worldwide. Distinguishing between ARF and septic arthritis may be difficult. This report describes a case of suppurative arthritis overlapping with ARF. CASE PRESENTATION: A 4-year-old, previously healthy boy presented with fever and left leg pain. The level of anti-streptolysin O (ASO) was elevated. His throat swab cultures grew GAS, but none were detected in his synovial fluid...
August 2015: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/25885601/concurrent-peritonsillar-abscess-and-poststreptococcal-reactive-arthritis-complicating-acute-streptococcal-tonsillitis-in-a-young-healthy-adult-a-case-report
#14
Elżbieta Mazur, Ewa Czerwińska, Aneta Grochowalska, Maria Kozioł-Montewka
BACKGROUND: Streptococcus pyogenes is responsible for 5-15% and 20-30% of acute pharyngitis/tonsillitis in adults and children, respectively. It not only causes acute illness but also can give rise to local suppurative complications such as peritonsillar abscess as well as trigger the postinfectious syndromes of glomerulonephritis, acute rheumatic fever and poststreptococcal reactive arthritis. Here, we report a case of a young healthy adult in whom both peritonsillar abscess and poststreptococcal reactive arthritis developed as a complication of acute streptococcal tonsillitis...
2015: BMC Infectious Diseases
https://www.readbyqxmd.com/read/25865969/ureaplasma-current-perspectives
#15
REVIEW
P Kokkayil, B Dhawan
Ureaplasma species are the most prevalent genital Mycoplasma isolated from the urogenital tract of both men and women. Ureaplasma has 14 known serotypes and is divided into two biovars- Ureaplasma parvum and Ureaplasma urealyticum. The organism has several genes coding for surface proteins, the most important being the gene encoding the Multiple Banded Antigen (MBA). The C-terminal domain of MBA is antigenic and elicits a host antibody response. Other virulence factors include phospholipases A and C, IgA protease and urease...
April 2015: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/25764807/-invasive-pneumococcal-disease-of-serotype-6c-with-skin-and-soft-tissue-infections-in-an-immunocompetent-adult
#16
Kiyozumi Suzuki, Yuta Hayashi, Hiromasa Otsuka, Kenichi Hashimoto, Yuji Kasamaki, Mitsuru Yanai, Kimitoshi Kato, Yu Nagai, Masayoshi Soma
We report herein on a rare case of deep-soft tissue infection due to invasive pneumococcal disease (IPD). A 77-year-old woman was admitted to our hospital with progressive pain in the right upper arm and the distal leg associated with swelling. We diagnosed the condition as multiple instances of cellulitis that were initially treated with ceftriaxone and clindamycin. Penicillin-susceptible Streptococcus pneumoniae (PSSP) was isolated from blood cultures on admission. Although inflammatory marker levels improved following susceptive antibiotic therapy (ampicillin), multiple abscesses, septic arthritis and osteomyelitis were detected with image testing...
November 2014: Kansenshōgaku Zasshi. the Journal of the Japanese Association for Infectious Diseases
https://www.readbyqxmd.com/read/25550499/septic-ankle-with-purulence-tracking-up-the-flexor-hallucis-longus-tendon-sheath-leading-to-deep-venous-thrombosis-pulmonary-embolism-and-compartment-syndrome
#17
Gregory R Waryasz, Philip McClure, Bryan G Vopat
UNLABELLED: The differential diagnosis for lower extremity swelling and ankle pain is broad and can have overlapping and related diagnoses. If there is concern for more than one diagnosis, the practitioner should perform a thorough physical examination, order the appropriate studies, and perform the correct procedures to completely diagnose and treat the patient. This article presents the case of a 19-year-old male who presented with 5 days of left ankle pain, fevers, and swelling without any known trauma to the area...
June 2015: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/25509765/-total-hip-arthroplasty-for-non-functional-bony-ankylosed-hip-in-young-and-middle-aged-patients
#18
Yingxu Fu, Boyong Yu, Asihaerjiang-Maimaitiyiming, Li Cao, Aili-Rehei
OBJECTIVE: To explore the effectiveness of total hip arthroplasty (THA) for non-functional bony ankylosed hip in young and middle-aged patients. METHODS: Between January 2010 and March 2013, 14 cases (19 hips) of non-functional bony ankylosed hip were treated by THA. There were 9 males and 5 females, aged 37.5 years on average (range, 23- 58 years). The left hip was involved in 6 cases, the right hip in 3 cases, and bilateral hips in 5 cases. The causes were tuberculosis in 2 patients, ankylosing spondylitis in 5 patients, traumatic arthritis in 5 patients, osteoarthritis in 1 patient, and suppurative infection in 1 patient...
September 2014: Chinese Journal of Reparative and Reconstructive Surgery
https://www.readbyqxmd.com/read/25315997/bedside-ultrasound-in-the-diagnosis-of-complex-hand-infections-a-case-series
#19
Brett A Marvel, Gavin R Budhram
BACKGROUND: The red, swollen, infected hand can be a diagnostically challenging presentation in the emergency department (ED). Hand infections are a relatively uncommon ED complaint, and diagnoses may range from simple cellulitis to deep space abscess, and even to suppurative flexor tenosynovitis. The accurate differentiation of these clinical entities is of paramount importance to healing and recovery of function. CASE SERIES: In this case series, we review 4 patients with similar presenting complaints of a red, swollen hand, but with much different diagnoses and eventual treatment strategies...
January 2015: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/25216320/inflamed-temporal-artery-histologic-findings-in-354-biopsies-with-clinical-correlations
#20
Alberto Cavazza, Francesco Muratore, Luigi Boiardi, Giovanna Restuccia, Nicolò Pipitone, Giulia Pazzola, Elena Tagliavini, Moira Ragazzi, Giulio Rossi, Carlo Salvarani
We reviewed 888 temporal artery biopsies (TAB) performed in 871 patients in a single institution from January 1986 to December 2013. Forty-four biopsies (4.9%) were inadequate, 490 (55.2%) were devoid of inflammation and were considered negative, and 354 (39.9%) showed inflammation and were considered positive. On the basis of the localization of the inflammation, positive TABs were further classified into 4 categories: small vessel vasculitis (SVV), in which inflammation was limited to small periadventitial vessels devoid of muscular coat, with sparing of the temporal artery (32 cases, 9% of the positive biopsies); vasa vasorum vasculitis (VVV), in which inflammation was limited to the adventitial vasa vasorum (23 cases, 6...
October 2014: American Journal of Surgical Pathology
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