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Achalsia

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https://www.readbyqxmd.com/read/15782818/inhibitory-effect-of-sildenafil-on-gastrointestinal-smooth-muscle-role-of-no-cgmp-transduction-pathway
#1
Chandrashekhar S Patil, Vijay Pal Singh, Naveen K Jain, Shrinivas K Kulkarni
Nitric oxide (NO) is an important neurotransmitter in the gut and has been demonstrated to be a key physiological mediator of non-adrenergic non-cholinergic (NANC) relaxation of gastrointestinal smooth muscle. In the present study the effect of PDE 5 inhibitor sildenafil on the gastrointestinal function (gastric emptying and intestinal transit) has been demonstrated in mice. Sildenafil (0.5-2 mg/kg, po) did not alter the percent gastric emptying however, in higher doses (5, 10 and 30 mg/kg, po) it inhibited the gastric emptying...
February 2005: Indian Journal of Experimental Biology
https://www.readbyqxmd.com/read/14467599/-achalsia-of-the-esophagus
#2
K S LYNKONES
No abstract text is available yet for this article.
April 1962: Hellenike Iatrike
https://www.readbyqxmd.com/read/1765245/effect-of-secretin-on-lower-esophageal-sphincter-pressure-in-patients-with-esophageal-achalasia
#3
M Miyata, T Sakamoto, T Hashimoto, M Nakamura, H Sakaguchi, Y Kawashima
The effect of a bolus intravenous administration of secretin (2.0 U/kg) on resting lower esophageal sphincter pressure (LESP) was investigated in seven patients with esophageal achalasia. Basal LESP before secretin injection in the patients was 60.1 +/- 3.4 mmHg (Mean +/- SEM), which was significantly higher than 26.9 +/- 2.5 mmHg in normal controls consisting of eight healthy volunteers. LESP significantly decreased within 1 min after the injection both in the patients and the controls. The maximum pressure change from each basal LESP was 31...
December 1991: Gastroenterologia Japonica
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