keyword
https://read.qxmd.com/read/38507932/saharan-dust-induces-the-lung-disease-related-cytokines-granulocyte-macrophage-colony-stimulating-factor-and-granulocyte-colony-stimulating-factor
#21
JOURNAL ARTICLE
Gerrit Bredeck, Jochen Dobner, Andrea Rossi, Roel P F Schins
Desert dust exposure is associated with adverse respiratory health effects. Desert dust is a complex pollutant mixtures that includes respirable crystalline and amorphous particles, metals, and microbial constituents. Given the health effects of desert dust and its heterogeneity, as yet unidentified harmful biological pathways may be triggered. Therefore, we exposed human in vitro air-liquid interface co-cultures of alveolar epithelial A549 cells and THP-1 macrophages to Saharan dust (SD). For comparison, we used the known pulmonary toxicant DQ12 quartz dust...
March 15, 2024: Environment International
https://read.qxmd.com/read/38504371/lipopolysaccharide-regulation-of-antiinflammatory-tristetraprolin-family-and-proinflammatory-gene-expression-in-mouse-macrophages
#22
JOURNAL ARTICLE
Heping Cao
OBJECTIVE: Tristetraprolin (TTP/ZFP36) family proteins exhibit antiinflammatory effects by destabilizing proinflammatory mRNAs. Previous studies showed that bacterial endotoxin lipopolysaccharides (LPS) stimulated TTP and tumor necrosis factor (TNF) gene expression, but less was known about LPS effects on TTP homologues and other proinflammatory gene expression in macrophages. The objective was to investigate LPS regulation of TTP family gene and TTP-targeted gene expression in mouse RAW264...
March 19, 2024: BMC Research Notes
https://read.qxmd.com/read/38503072/brain-mr-image-simulation-for-deep-learning-based-medical-image-analysis-networks
#23
JOURNAL ARTICLE
Aymen Ayaz, Yasmina Al Khalil, Sina Amirrajab, Cristian Lorenz, Jürgen Weese, Josien Pluim, Marcel Breeuwer
BACKGROUND AND OBJECTIVE: As large sets of annotated MRI data are needed for training and validating deep learning based medical image analysis algorithms, the lack of sufficient annotated data is a critical problem. A possible solution is the generation of artificial data by means of physics-based simulations. Existing brain simulation data is limited in terms of anatomical models, tissue classes, fixed tissue characteristics, MR sequences and overall realism. METHODS: We propose a realistic simulation framework by incorporating patient-specific phantoms and Bloch equations-based analytical solutions for fast and accurate MRI simulations...
March 7, 2024: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/38496134/a-case-of-autoimmune-pulmonary-alveolar-proteinosis-with-predominantly-peripheral-opacities-diagnosed-by-transbronchial-lung-biopsy
#24
Takeshi Imakura, Soji Kakiuchi, Mami Inayama, Ayaka Mori, Takashi Haku
Although pulmonary alveolar proteinosis (PAP) showed various shadows, its shadows are usually distributed predominantly in the central lung area. We report a case of autoimmune PAP with localized subpleural ground-glass shadows in the bilateral upper lobes, which was diagnosed based on transbronchial lung biopsy (TBLB) specimen findings and anti-granulocyte macrophage colony PAP stimulating factor antibody positivity. PAP should be listed as a differential diagnosis for subpleural shadows. If subpleural shadows are observed, TBLB should be performed aggressively, and anti-granulocyte macrophage colony-stimulating factor (anti-GM-CSF) antibodies should be submitted...
February 2024: Curēus
https://read.qxmd.com/read/38495883/strain-specific-differences-in-vitamin-d3-response-impact-on-gut-homeostasis
#25
JOURNAL ARTICLE
Laura Schreiber, Sakhila Ghimire, Andreas Hiergeist, Kathrin Renner, Michael Althammer, Nathalie Babl, Alice Peuker, Gabriele Schoenhammer, Katrin Hippe, Andre Gessner, Christin Albrecht, Fransziska Pielmeier, Maike Büttner-Herold, Heiko Bruns, Petra Hoffmann, Wolfgang Herr, Ernst Holler, Katrin Peter, Marina Kreutz, Carina Matos
Vitamin D3 regulates a variety of biological processes irrespective of its well-known importance for calcium metabolism. Epidemiological and animal studies indicate a role in immune regulation, intestinal barrier function and microbiome diversity. Here, we analyzed the impact of different vitamin D3- containing diets on C57BL/6 and BALB/c mice, with a particular focus on gut homeostasis and also investigated effects on immune cells in vitro . Weak regulatory effects were detected on murine T cells. By trend, the active vitamin D3 metabolite 1,25-dihydroxyvitamin D3 suppressed IFN, GM-CSF and IL-10 cytokine secretion in T cells of C57BL/6 but not BALB/c mice, respectively...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38495619/the-role-of-mitochondria-in-eosinophil-function-implications-for-severe-asthma-pathogenesis
#26
REVIEW
Janice Koranteng, Kian Fan Chung, Charalambos Michaeloudes, Pankaj Bhavsar
Mitochondria are key metabolic hubs involved in cellular energy production and biosynthesis. ATP is generated primarily by glucose and fatty acid oxidation through the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in the mitochondria. During OXPHOS there is also production of reactive oxygen species (ROS), which are involved in the regulation of cellular function. Mitochondria are also central in the regulating cell survival and death, particularly in the intrinsic apoptosis pathway...
2024: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/38490474/unique-cytokine-signature-in-ocular-stevens-johnson-syndrome-non-responders
#27
JOURNAL ARTICLE
Srividya Gurumurthy, Bhaskar Srinivasan, Shweta Agarwal, Hiren Matai, Narayanasamy Angayarkanni, Geetha Iyer
PURPOSE: To clinically define a subset of patients with chronic ocular Stevens-Johnson syndrome non-responders (SJS-NR) and analyze their cytokine profile compared to clinical responders (SJS-CR). METHODS: A total of 32 SJS cases (n = 32, 64 eyes) managed over a period of three years were segregated into clinical responders (n = 24, 48 eyes) and non-responders (n = 8, 16 eyes). Cases were determined as non-responders based on persistent, refractory, and non-mechanical inflammation of the conjunctiva...
March 13, 2024: Ocular Surface
https://read.qxmd.com/read/38485913/exosomes-derived-from-heat-shocked-tumor-cells-promote-in-vitro-maturation-of-bone-marrow-derived-dendritic-cells
#28
JOURNAL ARTICLE
Neda Heidari, Hajar Abbasi-Kenarsari, Bahare Niknam, Ali Asadirad, Davar Amani, Zahra Mirsanei, Seyed Mahmood Hashemi
Dendritic cells (DCs), professional antigen-presenting cells that process and deliver antigens using MHC II/I molecules, can be enhanced in numerous ways.  Exosomes derived from heat-shocked tumor cells (HS-TEXs) contain high amounts of heat-shock proteins (HSPs). HSPs, as chaperons, can induce DC maturation. This study aimed to investigate whether HS-TEXs can promote DC maturation. To generate DC, bone marrow-derived cells were treated with Interleukin-4 and GM-CSF. Exosomes were isolated from heat-treated CT-26 cells...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38484433/recognition-of-granulocyte-macrophage-colony-stimulating-factor-by-specific-s100-proteins
#29
JOURNAL ARTICLE
Alexey S Kazakov, Victoria A Rastrygina, Alisa A Vologzhannikova, Marina Y Zemskova, Lolita A Bobrova, Evgenia I Deryusheva, Maria E Permyakova, Andrey S Sokolov, Ekaterina A Litus, Marina P Shevelyova, Vladimir N Uversky, Eugene A Permyakov, Sergei E Permyakov
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pleiotropic myelopoietic growth factor and proinflammatory cytokine, clinically used for multiple indications and serving as a promising target for treatment of many disorders, including cancer, multiple sclerosis, rheumatoid arthritis, psoriasis, asthma, COVID-19. We have previously shown that dimeric Ca2+ -bound forms of S100A6 and S100P proteins, members of the multifunctional S100 protein family, are specific to GM-CSF. To probe selectivity of these interactions, the affinity of recombinant human GM-CSF to dimeric Ca2+ -loaded forms of 18 recombinant human S100 proteins was studied by surface plasmon resonance spectroscopy...
March 5, 2024: Cell Calcium
https://read.qxmd.com/read/38479572/autochthonous-cryptococcus-gattii-genotype-vgiib-infection-in-a-japanese-patient-with-anti-granulocyte-macrophage-colony-stimulating-factor-antibodies
#30
Tsuyoshi Hamaguchi, Nobuaki Uchida, Michiyo Fujita-Nakata, Megumi Nakanishi, Yasuhiro Tsuchido, Miki Nagao, Yoshitsugu Iinuma, Masato Asahina
A 31-year-old Japanese man presented with cerebral and pulmonary cryptococcosis. Cryptococcus gattii (C. gattii) genotype VGIIb was detected in the patient's sputum and cerebrospinal fluid specimens. The serum levels of anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibodies were elevated in this patient, which has been associated with pulmonary alveolar proteinosis and is considered a risk factor for C. gattii infection. After undergoing >12 months of antifungal treatments, the patient showed improvements in symptoms and findings on brain and lung imaging...
March 11, 2024: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://read.qxmd.com/read/38476921/therapeutic-effect-of-notoginseng-saponins-before-and-after-fermentation-on-blood-deficiency-rats
#31
JOURNAL ARTICLE
Wenjie Su, Zuguo Liang, Daian Pan, Lancao Zhang, Yuyao Zhang, Tongyi Yuan, Xiang Gao, Hang Su, He Zhang
Notoginseng saponins (NS) are the active ingredients in Panax notoginseng (Burk.) F.H. Chen (PN). NS can be transformed depending on how the extract is processed. Fermentation has been shown to produce secondary ginsenosides with increased bioavailability. However, the therapeutic effect of fermented NS (FNS) requires further study. The present study compared the compositions and activities of FNS and NS in blood deficiency rats, which resembles the symptoms of anemia in modern medicine, induced by acetylphenylhydrazine and cyclophosphamide...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38474629/anti-inflammatory-effect-of-chamaecyparis-obtusa-siebold-zucc-endl-leaf-essential-oil
#32
JOURNAL ARTICLE
Sung-Hee Kim, Young-Ah Jang, Yong-Jin Kwon
Chamaecyparis obtusa (Siebold & Zucc.) Endl. ( C. obtusa ) belongs to the Cupressaceae family and is native to East Asian regions. Essential oils extracted from the leaves, bark, branches, and roots of C. obtusa have both aesthetic and medicinal properties and are thus widely used. However, detailed analyses of the active ingredients of C. obtusa extract are lacking. In this study, the sabinene content in the hydro-distillation of C. obtusa leaf essential oil (COD) was analyzed using GC-MS, and the anti-inflammatory effect of COD was compared with that of pure sabinene...
March 1, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38468395/exploration-of-the-clinical-effect-of-different-autotransfusion-methods-on-patients-with-femoral-shaft-fracture-surgery
#33
JOURNAL ARTICLE
Yujia Wang, Huan Wang, Jiaming Xu, Jinhuo Wang, Laiwei You, Yu Bai, Jianrong Guo
OBJECTIVE: To explore the clinical effect of predeposit, salvage, and hemodilution autotransfusion on patients with femoral shaft fracture (FSF) surgery. METHODS: Selected patients with FSF were randomly divided into three groups: intraoperative blood salvage autotransfusion, preoperative hemodilution autohemotransfusion, and predeposit autotransfusion. Five days after the operation, the body temperature, heart rate, blood platelet (PLT), and hemoglobin (Hb) of patients were determined...
March 11, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38466157/lifetime-stressful-events-associated-with-alzheimer-s-pathologies-neuroinflammation-and-brain-structure-in-a-risk-enriched-cohort
#34
JOURNAL ARTICLE
Eleni Palpatzis, Muge Akinci, Pablo Aguilar-Dominguez, Marina Garcia-Prat, Kaj Blennow, Henrik Zetterberg, Margherita Carboni, Gwendlyn Kollmorgen, Norbert Wild, Karine Fauria, Carles Falcon, Juan Domingo Gispert, Marc Suárez-Calvet, Oriol Grau-Rivera, Gonzalo Sánchez-Benavides, Eider M Arenaza-Urquijo
OBJECTIVE: Along with the known effects of stress on brain structure and inflammatory processes, increasing evidence suggest a role of chronic stress in the pathogenesis of Alzheimer's disease (AD). We investigated the association of accumulated stressful life events (SLEs) with AD pathologies, neuroinflammation, and gray matter (GM) volume among cognitively unimpaired (CU) individuals at heightened risk of AD. METHODS: This cross-sectional cohort study included 1,290 CU participants (aged 48-77) from the ALFA cohort with SLE, lumbar puncture (n = 393), and/or structural magnetic resonance imaging (n = 1,234) assessments...
March 11, 2024: Annals of Neurology
https://read.qxmd.com/read/38460634/pgm-csf-as-an-adjuvant-in-dna-vaccination-against-sars-cov-2
#35
JOURNAL ARTICLE
Chang Liu, Ruo-Yi Xue, Guo-Cheng Li, Yi Zhang, Wei-Yi Wu, Jing-Yi Liu, Rang Feng, Zhe Jin, Yan Deng, Zi-Li Jin, Hao Cheng, Ling Mao, Quan-Ming Zou, Hai-Bo Li
The emergence of SARS-CoV-2 presents a significant global public health dilemma. Vaccination has long been recognized as the most effective means of preventing the spread of infectious diseases. DNA vaccines have attracted attention due to their safety profile, cost-effectiveness, and ease of production. This study aims to assess the efficacy of plasmid-encoding GM-CSF (pGM-CSF) as an adjuvant to augment the specific humoral and cellular immune response elicited by DNA vaccines based on the receptor-binding domain (RBD) antigen...
March 7, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38458816/evaluation-of-the-efficacy-and-safety-of-a-precise-thymalfasin-regulated-prag-regimen-for-advanced-refractory-solid-tumours-protocol-for-the-open-label-prospective-multicentre-study-prag5-0-study
#36
JOURNAL ARTICLE
Yuehong Kong, Rongzheng Chen, Meiling Xu, Junjun Zhang, Guangqiang Chen, Zhihui Hong, Hong Zhang, Xiaoxiao Dai, Yifu Ma, Xiangrong Zhao, Yong Peng, Chenyang Zhang, Pengfei Xing, Liyuan Zhang
INTRODUCTION: The PRaG regimen, which consists of hypofractionated radiotherapy combined with a programmed cell death-1/programmed cell death ligand-1 (PD-1/PD-L1) inhibitor and granulocyte-macrophage colony stimulating factor (GM-CSF), has been demonstrated to have a survival benefit in patients with advanced solid tumours who have failed at least two lines of treatment. Nonetheless, lymphopenia poses an impediment to the enduring efficacy of PD-1/PD-L1 inhibitor therapy. Adequate lymphocyte reserves are essential for the efficacy of immunotherapy...
March 8, 2024: BMJ Open
https://read.qxmd.com/read/38457343/bactericidal-permeability-increasing-protein-instructs-dendritic-cells-to-elicit-th22-cell-response
#37
JOURNAL ARTICLE
Sigrid Bülow, Katharina U Ederer, Jonas M Holzinger, Lisa Zeller, Maren Werner, Martina Toelge, Christina Pfab, Sarah Hirsch, Franziska Göpferich, Andreas Hiergeist, Friederike Berberich-Siebelt, André Gessner
Neutrophil-derived bactericidal/permeability-increasing protein (BPI) is known for its bactericidal activity against gram-negative bacteria and neutralization of lipopolysaccharide. Here, we define BPI as a potent activator of murine dendritic cells (DCs). As shown in GM-CSF-cultured, bone-marrow-derived cells (BMDCs), BPI induces a distinct stimulation profile including IL-2, IL-6, and tumor necrosis factor expression. Conventional DCs also respond to BPI, while M-CSF-cultivated or peritoneal lavage macrophages do not...
March 6, 2024: Cell Reports
https://read.qxmd.com/read/38454393/inducing-expression-of-icos-l-by-oncolytic-adenovirus-to-enhance-tumor-specific-bi-specific-antibody-efficacy
#38
JOURNAL ARTICLE
Neshat Saffarzadeh, Emelie Foord, Eoghan O'Leary, Rand Mahmoun, Thomas Birkballe Hansen, Victor Levitsky, Thomas Poiret, Michael Uhlin
BACKGROUND: Intratumoral injection of oncolytic viruses (OVs) shows promise in immunotherapy: ONCOS-102, a genetically engineered OV that encodes Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) demonstrated efficacy in early clinical trials, enhancing T cell infiltration in tumors. This suggests OVs may boost various forms of immunotherapy, including tumor-specific bi-specific antibodies (BsAbs). METHODS: Our study investigated in vitro, how ONCOS-204, a variant of ONCOS-virus expressing the ligand of inducible T-cell co-stimulator (ICOSL), modulates the process of T cell activation induced by a BsAb...
March 7, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38443899/sex-related-differences-in-serum-biomarker-levels-predict-the-activity-and-efficacy-of-immune-checkpoint-inhibitors-in-advanced-melanoma-and-non-small-cell-lung-cancer-patients
#39
JOURNAL ARTICLE
Giulia Pasello, Aline S C Fabricio, Paola Del Bianco, Valentina Salizzato, Adolfo Favaretto, Luisa Piccin, Fable Zustovich, Alessio Fabozzi, Costanza De Rossi, Jacopo Pigozzo, Mattia De Nuzzo, Elia Cappelletto, Laura Bonanno, Dario Palleschi, Gian Luca De Salvo, Valentina Guarneri, Massimo Gion, Vanna Chiarion-Sileni
BACKGROUND: Immune Checkpoint Inhibitors (ICIs) lead to durable response and a significant increase in long-term survival in patients with advanced malignant melanoma (MM) and Non-Small Cell Lung Cancer (NSCLC). The identification of serum cytokines that can predict their activity and efficacy, and their sex interaction, could improve treatment personalization. METHODS: In this prospective study, we enrolled immunotherapy-naïve patients affected by advanced MM and NSCLC treated with ICIs...
March 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38442443/plasmatic-profiles-of-cytokines-chemokines-glial-fibrillary-acidic-protein-gfap-and-mri-brain-damage-in-neonates-with-hypoxic-ischemic-encephalopathy-hie
#40
JOURNAL ARTICLE
Cinzia Auriti, Vito Mondì, Fiammetta Piersigilli, Laura Timelli, Tamara Del Pinto, Giusi Prencipe, Giulia Lucignani, Daniela Longo, Iliana Bersani
BACKGROUND: Perinatal hypoxia triggers the release of cytokines and chemokines by neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, producing proinflammatory molecules. The brain damage extension seems to be related to both the severity of hypoxia and the balance between pro and anti-inflammatory response and can be explored with neuroimaging. AIMS: The aim of this preliminary study was to explore possible relationships between plasma levels of inflammatory cytokines/chemokines and the severe brain damage detectable by Magnetic Resonance Imaging (MRI), performed during the hospitalization...
May 2024: Cytokine
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