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functional MRI Lupus

Sakon Noriki, Kazuyuki Kinoshita, Kunihiro Inai, Toyohiko Sakai, Hirohiko Kimura, Takahiro Yamauchi, Masayuki Iwano, Hironobu Naiki
BACKGROUND: Postmortem imaging (PMI) refers to the imaging of cadavers by computed tomography (CT) and/or magnetic resonance imaging (MRI). Three cases of cerebral infarctions that were not found during life but were newly recognized on PMI and were associated with severe systemic infections are presented. CASE PRESENTATIONS: An 81-year-old woman with a pacemaker and slightly impaired liver function presented with fever. Imaging suggested interstitial pneumonia and an iliopsoas abscess, and blood tests showed liver dysfunction and disseminated intravascular coagulation (DIC)...
January 10, 2017: BMC Medical Imaging
Swati Vishwanathan, Michael Lucke, Indu G Poornima
A woman aged 22 years with a history of lupus presented in the 18th week of pregnancy with hypertensive emergency and flash pulmonary oedema. Bedside echocardiogram revealed severe left ventricular (LV) dysfunction with an ejection fraction (EF) of 25% and pericardial effusion. Laboratories revealed hypocomplementemia, proteinuria, elevated C reactive protein and anti-DS-DNA, raising concern for a lupus flare. Cardiac MRI showed an acute intramyocardial oedematous process, consistent with lupus carditis, and further worsening of LVEF to 13%...
October 4, 2016: BMJ Case Reports
S J Wiseman, M E Bastin, I F Hamilton, D Hunt, S J Ritchie, E N Amft, S Thomson, J F F Belch, S H Ralston, J M Wardlaw
OBJECTIVE: The objective of this study was to investigate fatigue and cognitive impairments in systemic lupus erythematous (SLE) in relation to diffuse white matter microstructural brain damage. METHODS: Diffusion tensor MRI, used to generate biomarkers of brain white matter microstructural integrity, was obtained in patients with SLE and age-matched controls. Fatigue and cognitive function were assessed and related to SLE activity, clinical data and plasma biomarkers of inflammation and endothelial dysfunction...
September 29, 2016: Lupus
Xiao Dong Zhang, Xiao Lu Jiang, Zhen Cheng, Yan Zhou, Qiang Xu, Zhi Qiang Zhang, Rongfeng Qi, Song Luo, Yan Su Yun, Hui Juan Chen, Xiang Kong, Guang Ming Lu, Long Jiang Zhang
In this study, we seek to explore alterations of coupling between functional connectivity density (FCD) and amplitude of low frequency fluctuation (ALFF) in systemic lupus erythematosus patients without overt neuropsychiatric symptoms (non-NPSLE) by using resting-state functional MR imaging. This study was approved by the institutional ethical review board, and all participants signed written informed consent prior to the study. Twenty six non-NPSLE patients and 35 matched healthy controls underwent resting-state functional MR imaging...
August 30, 2016: Molecular Neurobiology
Beatriz Lavras Costallat, Daniel Miranda Ferreira, Lilian Tereza Lavras Costallat, Simone Appenzeller
OBJECTIVE: To describe clinical, laboratory, radiological and progression characteristics of myelopathy in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: A retrospective analysis was performed on a cohort of 1193 patients with SLE (ACR criteria) in order to identify patients with myelopathy (neuropsychiatric ACR). Disease activity was assessed by the SLE activity index (SLEDAI) on the date of the event and functional capacity was assessed by the Expanded Disability Status Scale (EDSS) at the last visit...
May 2016: Revista Brasileira de Reumatologia
Gaurav Gulati, Jordan T Jones, Gregory Lee, Mekibib Altaye, Dean W Beebe, Jamie Meyers-Eaton, Kasha Wiley, Hermine I Brunner, Mark W DiFrancesco
OBJECTIVE: To evaluate a safe, non-invasive MRI method to measure regional blood brain barrier (BBB) integrity and investigate its relationship with neurocognitive function and regional gray matter volume (GMV) in childhood-onset SLE (cSLE). METHODS: In this cross-sectional, case-control study, capillary permeability was measured as a marker of BBB integrity in cSLE patients and matched healthy controls, using a combination of arterial spin labeling and diffusion-weighted brain MRI...
April 25, 2016: Arthritis Care & Research
Beatriz Lavras Costallat, Daniel Miranda Ferreira, Lilian Tereza Lavras Costallat, Simone Appenzeller
OBJECTIVE: To describe clinical, laboratory, radiological and progression characteristics of myelopathy in systemic lupus erythematosus (SLE). PATIENTS AND METHODS: A retrospective analysis was performed on a cohort of 1193 patients with SLE (ACR criteria) in order to identify patients with myelopathy (neuropsychiatric ACR). Disease activity was assessed by the SLE activity index (Sledai) on the date of the event and functional capacity was assessed by the Expanded Disability Status Scale (EDSS) at the last visit...
March 9, 2016: Revista Brasileira de Reumatologia
E Kozora, A M Uluğ, D Erkan, A Vo, C M Filley, G Ramon, A Burleson, R Zimmerman, M D Lockshin
OBJECTIVE: Standardized cognitive tests and functional magnetic resonance imaging (fMRI) studies of SLE patients demonstrate deficits in working memory and executive function. These neurobehavioral abnormalities are not well studied in antiphospholipid syndrome (APS), which may occur independently of or together with SLE. This study compares an fMRI paradigm involving motor, working memory and executive function in SLE patients without antiphospholipid antibody (SLE), aPL-positive non-SLE patients (aPL+), and controls...
March 4, 2016: Arthritis Care & Research
Zhiyan Zhang, Yukai Wang, Zhiwei Shen, Zhongxian Yang, Li Li, Dongxiao Chen, Gen Yan, Xiaofang Cheng, Yuanyu Shen, Xiangyong Tang, Wei Hu, Renhua Wu
The diagnosis and pathology of neuropsychiatric systemic lupus erythematosus (NPSLE) remains challenging. Herein, we used multimodal imaging to assess anatomical and functional changes in brains of SLE patients instead of a single MRI approach generally used in previous studies. Twenty-two NPSLE patients, 21 non-NPSLE patients and 20 healthy controls (HCs) underwent 3.0 T MRI with multivoxel magnetic resonance spectroscopy, T1-weighted volumetric images for voxel based morphometry (VBM) and diffusional kurtosis imaging (DKI) scans...
January 13, 2016: Scientific Reports
E Carnero Contentti, J P Hryb, F Leguizamón, J L Di Pace, J Celso, E Knorre, M B Perassolo
INTRODUCTION: Longitudinally extensive myelitis (LETM) has classically been grouped with the full or limited neuromyelitis optica spectrum disorders (NMOSD). However, differential diagnosis reveals a wide range of aetiologies. OBJECTIVE: To report on differential diagnosis and prognosis for LETM observed in a group of patients in Buenos Aires, Argentina. PATIENTS AND METHODS: Cross-sectional and retrospective multicentre study in two hospitals in Buenos Aires from June 2008 to June 2014...
October 30, 2015: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Claudia Elera-Fitzcarrald, José L Alfaro-Lozano, César A Pastor-Asurza
We report the case of a 35-year-old male, who was diagnosed with systemic lupus erythematosus (SLE) in 2010 based on the presence of articular, serous, renal, immune, and hematologic involvement. He also had secondary antiphospholipid syndrome (APS). He was treated with prednisone 10 mg per day, hydroxychloroquine 200 mg per day, methotrexate 12.5 mg per week, leflunomide 20 mg per day, and oral anticoagulation previous to the present event. He presented to emergency room with a 7 day disease duration characterized by pain in the left thigh, which increased with physical activity, resulting in claudication; he also had malaise and fever...
December 2015: Clinical Rheumatology
Yoshiharu Ohno, Hisanobu Koyama, Takeshi Yoshikawa, Shinichiro Seki
Involvement of the respiratory system is common in connective tissue diseases (CTDs), and the resultant lung injury can affect every part of the lung: the pleura, alveoli, interstitium, vasculature, lymphatic tissue, and large and/or small airways. Most of the parenchymal manifestations of CTD are similar to those found in interstitial lung diseases (ILDs), especially idiopathic interstitial pneumonias, and can be classified using the same system. Although there is some overlap, each CTD is associated with a characteristic pattern of pulmonary involvement...
December 2015: Current Rheumatology Reports
Takeshi Kuroda, Naohito Tanabe, Ayako Wakamatsu, Chinatsu Takai, Hiroe Sato, Takeshi Nakatsue, Yoko Wada, Masaaki Nakano, Ichiei Narita
The purpose of this study was to clarify the factors related to silent osteonecrosis of the femoral head (ONFH) in patients with systemic lupus erythematosus (SLE). Seventy-eight patients with SLE were selected on the basis of having been newly diagnosed and requiring high-dose prednisolone, including pulse therapy with methylprednisolone, as the initial treatment. All the patients initially underwent MRI at 3 months after the start of corticosteroid treatment to detect any early changes in the femoral head...
December 2015: Clinical Rheumatology
Mittermayer B Santiago, Verena Galvão, Daniel Sá Ribeiro, Willer D Santos, Priscila R da Hora, Anna Paula Mota, Emanuela Pimenta, Isabela Oliveira, Ajax M Atta, Mitermayer G Reis, Eliana A G Reis, Carolina Lins
Jaccoud's arthropathy (JA) is a clinical situation nowadays present mostly in systemic lupus erythematosus (SLE). It is characterized by the presence of joint deformities such as "swan neck," ulnar deviation and "Z-thumb" resembling rheumatoid arthritis (RA) but that are passively correctable and without bone erosion on plain radiographs. From our cohort of SLE patients with JA, we selected a subgroup with a more severe form of this arthropathy and looked at their clinical and laboratory profile as well as studied the magnetic resonance imaging (MRI) findings or ultrasound (US) obtained from the hand with most evident deformities...
October 2015: Rheumatology International
Nicolle Zimmermann, Diogo Goulart Corrêa, Tadeu Almodovar Kubo, Tania Maria Netto, Denis Batista Pereira, Rochele Paz Fonseca, Emerson Leandro Gasparetto
OBJECTIVE: This study investigated differences in subcortical brain volumes of SLE patients with cognitive deficits (SLE-CD) and SLE patients with normal cognitive performance (SLE-CN), regardless of the presence of other neuropsychiatric symptoms. METHOD: We studied 40 patients divided into two-matched groups (SLE-CD n = 20; SLE-CN n = 20), with age ranging from 21 to 63 years old (100 % female) and 14.73 ± 10.18 years of diagnosis. Magnetic resonance imaging exams were performed on a 1...
May 13, 2015: Clinical Neuroradiology
Gerwyn Morris, Michael Berk, Ken Walder, Michael Maes
BACKGROUND: The genesis of severe fatigue and disability in people following acute pathogen invasion involves the activation of Toll-like receptors followed by the upregulation of proinflammatory cytokines and the activation of microglia and astrocytes. Many patients suffering from neuroinflammatory and autoimmune diseases, such as multiple sclerosis, Parkinson's disease and systemic lupus erythematosus, also commonly suffer from severe disabling fatigue. Such patients also present with chronic peripheral immune activation and systemic inflammation in the guise of elevated proinflammtory cytokines, oxidative stress and activated Toll-like receptors...
February 6, 2015: BMC Medicine
Niall P McGoldrick, Fergal J McGoldrick
BACKGROUND: Isolated avascular necrosis of the metacarpal head, also known as Dietrich's disease, is a rare entity with few cases reported previously in the literature. It has been associated with steroid use, lupus, and trauma. We describe the clinical presentation, pathogenesis, and treatment options associated with this uncommon condition. CASE REPORT: A 36-year-old man presented with a 1-year history of a painful right middle finger metacarpophalangeal joint (MCPJ)...
2015: American Journal of Case Reports
Yan Zhang, Celia P Corona-Villalobos, Adnan N Kiani, John Eng, Ihab R Kamel, Stefan L Zimmerman, Michelle Petri
To evaluate whether T2 mapping techniques can detect myocardial edema in patients with systemic lupus erythematosus (SLE). Twenty-four patients (mean age 54 ± 9 years) with SLE and twelve controls (mean age 50 ± 7 years) underwent cardiac MRI at 1.5 T. Standard cine images were obtained. Single-slice T2 maps and non-contrast T1 maps were acquired in a mid-cavity short-axis plane. Late gadolinium enhancement (LGE) images were obtained 15 min after 0.2 mmol/kg of contrast. SLE patients had low disease activity (mean SLE disease activity index score 0...
February 2015: International Journal of Cardiovascular Imaging
Eric Boccio, Fiore Mastroianni, Todd Slesinger
Critical Care Student/Resident Case Report Posters ISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: Posterior Reversible Encephalopathy Syndrome (PRES) is a neurotoxic state defined by variable clinical signs and symptoms, unique radiological features, and general reversibility of the condition. Presentation may include headache, nausea, vomiting, altered mental status, seizures, and visual loss or disturbances. Neuroimaging shows characteristic transient changes, and diagnosis is typically made using MRI...
October 1, 2014: Chest
Nilson Lopez-Ruiz, Carlos Esteban Uribe
A 36-year-old woman who had received long-term treatment with chloroquine for systemic lupus erythematosus developed a third degree atrioventricular block and required a permanent pacemaker. Notably, left ventricular thickening and mild systolic dysfunction were noticed on echocardiography as well as on cardiac MRI. As there was no clear explanation for myocardial findings, the patient underwent an endomyocardial biopsy that demonstrated vacuolar degeneration of myocytes on light microscopy and curvilinear bodies on electron microscopy, both findings consistent with chloroquine toxicity...
2014: BMJ Case Reports
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