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Asthma cluster analysis

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https://www.readbyqxmd.com/read/29029627/determinants-of-self-rated-health-among-shanghai-elders-a-cross-sectional-study
#1
Weizhen Dong, Jin Wan, Yanjun Xu, Chun Chen, Ge Bai, Lyuying Fang, Anjiang Sun, Yinghua Yang, Ying Wang
BACKGROUND: As the most populous nation in the world, China has now becoming an emerging ageing society. Shanghai is the first city facing the challenge of ageing demographics. Against this background, a study that employs self-rated health (SRH) assessment system was designed to explore the health status of Shanghai elders, and learn their attitudes toward health issues; as well as to investigate the determinants of SRH among Shanghai elders. Understanding SRH is crucial for finding appropriate solutions that could effectively tackle the increasing eldercare demand...
October 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29029580/uncovering-longitudinal-health-care-behaviors-for-millions-of-medicaid-enrollees-a-multistate-comparison-of-pediatric-asthma-utilization
#2
Ross Hilton, Yuchen Zheng, Anne Fitzpatrick, Nicoleta Serban
BACKGROUND: This study introduces a framework for analyzing and visualizing health care utilization for millions of children, with a focus on pediatric asthma, one of the major chronic respiratory conditions. METHODS: The data source is the 2005 to 2012 Medicaid Analytic Extract claims for 10 Southeast states. The study population consists of Medicaid-enrolled children with persistent asthma. We translate multiyear, individual-level medical claims into sequences of discrete utilization events, which are modeled using Markov renewal processes and model-based clustering...
October 1, 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/29025889/characterisation-of-asthma-subgroups-associated-with-circulating-ykl-40-levels
#3
Jose L Gomez, Xiting Yan, Carole T Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova, Deborah A Meyers, Eugene R Bleecker, Gina M Crisafi, Nizar N Jarjour, Linda Rogers, Joan Reibman, Geoffrey L Chupp
The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) and the New York University/Bellevue Asthma Repository (n=341)...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28986128/vitamin-d-supplementation-to-prevent-asthma-exacerbations-a-systematic-review-and-meta-analysis-of-individual-participant-data
#4
David A Jolliffe, Lauren Greenberg, Richard L Hooper, Christopher J Griffiths, Carlos A Camargo, Conor P Kerley, Megan E Jensen, David Mauger, Iwona Stelmach, Mitsuyoshi Urashima, Adrian R Martineau
BACKGROUND: A previous aggregate data meta-analysis of randomised controlled trials showed that vitamin D supplementation reduces the rate of asthma exacerbations requiring treatment with systemic corticosteroids. Whether this effect is restricted to patients with low baseline vitamin D status is unknown. METHODS: For this systematic review and one-step and two-step meta-analysis of individual participant data, we searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, and Web of Science for double-blind, placebo-controlled, randomised controlled trials of vitamin D3 or vitamin D2 supplementation in people with asthma that reported incidence of asthma exacerbation, published between database inception and Oct 26, 2016...
October 3, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28974677/longitudinal-outcomes-of-different-asthma-phenotypes-in-primary-care-an-observational-study
#5
Rishi J Khusial, Jacob K Sont, Rik J B Loijmans, Jiska B Snoeck-Stroband, Pim J J Assendelft, Tjard R J Schermer, Persijn J Honkoop
While asthma presentation is heterogeneous, current asthma management guidelines in primary care are quite homogeneous. In this study we aim to cluster patients together into different phenotypes, that may aid the general practitioner in individualised asthma management. We analysed data from the ACCURATE trial, containing 611 adult asthmatics, 18-50 year-old, treated in primary care, with one year follow-up. Variables obtained at baseline (n = 14), were assessed by cluster analysis. Subsequently, established phenotypes were assessed separately on important asthma outcomes after one year follow-up: asthma control (Asthma Control Questionnaire (ACQ)), quality of life (Asthma Quality of Life Questionnaire (AQLQ)), exacerbation-rate and medication-usage...
October 3, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28972652/shared-decision-making-for-people-with-asthma
#6
REVIEW
Kayleigh M Kew, Poonam Malik, Krishnan Aniruddhan, Rebecca Normansell
BACKGROUND: Asthma is a chronic inflammatory disease that affects the airways and is common in both adults and children. It is characterised by symptoms including wheeze, shortness of breath, chest tightness, and cough. People with asthma may be helped to manage their condition through shared decision-making (SDM). SDM involves at least two participants (the medical practitioner and the patient) and mutual sharing of information, including the patient's values and preferences, to build consensus about favoured treatment that culminates in an agreed action...
October 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28960398/nasal-protein-profiles-in-work-related-asthma-caused-by-different-exposures
#7
Hille Suojalehto, Irmeli Lindström, Henrik Wolff, Anne Puustinen
BACKGROUND: The mechanisms of work-related asthma are incompletely delineated. Nasal cell samples may be informative about processes in the lower airways. Our aim was to determine the nasal protein expression profiles of work-related asthma caused by different kind of exposures. METHODS: We collected nasal brush samples from 82 non-smoking participants, including healthy controls and work-related asthma patients exposed to 1) protein allergens, 2) isocyanates, and 3) welding fumes the day after relevant exposure...
September 28, 2017: Allergy
https://www.readbyqxmd.com/read/28929787/-phenotypes-of-bronchial-asthma
#8
László Béla Nagy
It is increasingly recognized that the bronchial asthma is a heterogeneous entity, encompassing a variety of different phenotypes. The identification of specific phenotypes is the key to develop more effective personalised treatment. The earliest attempt to phenotype asthma was proposed classifying into extrinsic and intrinsic subtypes. Clinical asthma is mainly divided into allergic (atopic) and non-allergic (non-atopic) asthma. Other phenotypes are based on trigger factors. Later the phenotyping based on the predominant cellular nature of inflammation: It can be divided into eosinophilic and non-eosinohilic...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28918658/the-role-of-upper-airway-pathology-as-a-co-morbidity-in-severe-asthma
#9
Amelia Licari, Ilaria Brambilla, Maria De Filippo, Dimitri Poddighe, Riccardo Castagnoli, Gian Luigi Marseglia
Severe asthma is a complex heterogeneous disease that is refractory to standard treatment and is complicated by multiple co-morbidities and risk factors. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Areas covered: A prevalent cluster of chronic upper airway co-morbid diseases is recognized in severe asthma. Evaluation for these disorders should always be considered in clinical practice. The aim of this review is to provide an updated overview of the prevalence, the pathogenetic mechanisms, the clinical impact and the therapeutic options for upper airway pathology in severe asthma, focusing on chronic rhinosinusitis and allergic rhinitis...
September 16, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28913987/clinical-characteristics-of-exacerbation-prone-adult-asthmatics-identified-by-cluster-analysis
#10
Mi Ae Kim, Seung Woo Shin, Jong Sook Park, Soo Taek Uh, Hun Soo Chang, Da Jeong Bae, You Sook Cho, Hae Sim Park, Ho Joo Yoon, Byoung Whui Choi, Yong Hoon Kim, Choon Sik Park
PURPOSE: Asthma is a heterogeneous disease characterized by various types of airway inflammation and obstruction. Therefore, it is classified into several subphenotypes, such as early-onset atopic, obese non-eosinophilic, benign, and eosinophilic asthma, using cluster analysis. A number of asthmatics frequently experience exacerbation over a long-term follow-up period, but the exacerbation-prone subphenotype has rarely been evaluated by cluster analysis. This prompted us to identify clusters reflecting asthma exacerbation...
November 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28910142/distinct-phenotypes-of-smokers-with-fixed-airflow-limitation-identi%C3%AF-ed-by-cluster-analysis-of-severe-asthma
#11
Satoshi Konno, Natsuko Taniguchi, Hironi Makita, Yuji Nakamaru, Kaoruko Shimizu, Noriharu Shijubo, Satoshi Fuke, Kimihiro Takeyabu, Mitsuru Oguri, Hirokazu Kimura, Yukiko Maeda, Masaru Suzuki, Katsura Nagai, Yoichi M Ito, Sally E Wenzel, Masaharu Nishimura
RATIONALE: Smoking may have multifactorial effects on asthma phenotypes, particularly in severe asthma. Cluster analysis has been applied to explore novel phenotypes, which are not based on any priori hypotheses. OBJECTIVE: To explore novel severe asthma phenotypes by cluster analysis when including smoking asthmatics. METHODS: We recruited a total of 127 subjects with severe asthma, including 59 current or ex-smokers, from our university hospital and its 29 affiliated hospitals/pulmonary clinics...
September 14, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28886711/structure-and-functional-impact-of-seed-region-variant-in-mir-499-gene-family-in-bronchial-asthma
#12
Eman A Toraih, Mohammad H Hussein, Essam Al Ageeli, Eman Riad, Nouran B AbdAllah, Ghada M Helal, Manal S Fawzy
BACKGROUND: Small non-coding RNAs (microRNAs) have been evolved to master numerous cellular processes. Genetic variants within microRNA seed region might influence microRNA biogenesis and function. The study aimed at determining the role of microRNA-499 (MIR-499) gene family polymorphism as a marker for susceptibility and progression of bronchial asthma and to analyze the structural and functional impact of rs3746444 within the seed region. METHODS: Genotyping for 192 participants (96 patients and 96 controls) in the discovery phase and 319 subjects (115 patients and 204 controls) in the replication phase was performed via Real Time-Polymerase Chain Reaction technology...
September 8, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28866644/functional-phenotypes-determined-by-fluctuation-based-clustering-of-lung-function-measurements-in-healthy-and-asthmatic-cohort-participants
#13
Edgar Delgado-Eckert, Oliver Fuchs, Nitin Kumar, Juha Pekkanen, Jean-Charles Dalphin, Josef Riedler, Roger Lauener, Michael Kabesch, Maciej Kupczyk, Sven-Erik Dahlà N, Erika von Mutius, Urs Frey
RATIONALE: Asthma is characterised by inflammation and reversible airway obstruction. However, these features are not always closely related. Fluctuations of daily lung function contain information on asthma phenotypes, exacerbation risk and response to long-acting β-agonists. OBJECTIVES: In search of subgroups of asthmatic participants with specific lung functional features, we developed and validated a novel clustering approach to asthma phenotyping, which exploits the information contained within the fluctuating behaviour of twice-daily lung function measurements...
September 2, 2017: Thorax
https://www.readbyqxmd.com/read/28866310/identification-and-validation-of-asthma-phenotypes-in-chinese-population-using-cluster-analysis
#14
Lei Wang, Rui Liang, Ting Zhou, Jing Zheng, Bing Miao Liang, Hong Ping Zhang, Feng Ming Luo, Peter G Gibson, Gang Wang
BACKGROUND: Asthma is a heterogeneous airway disease, so it is crucial to clearly identify clinical phenotypes to achieve better asthma management. OBJECTIVE: To identify and prospectively validate asthma clusters in a Chinese population. METHODS: Two hundred eighty-four patients were consecutively recruited and 18 sociodemographic and clinical variables were collected. Hierarchical cluster analysis was performed by the Ward method followed by k-means cluster analysis...
October 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28858242/effect-of-processing-intensity-on-immunologically-active-bovine-milk-serum-proteins
#15
Tabea Brick, Markus Ege, Sjef Boeren, Andreas Böck, Erika von Mutius, Jacques Vervoort, Kasper Hettinga
Consumption of raw cow's milk instead of industrially processed milk has been reported to protect children from developing asthma, allergies, and respiratory infections. Several heat-sensitive milk serum proteins have been implied in this effect though unbiased assessment of milk proteins in general is missing. The aim of this study was to compare the native milk serum proteome between raw cow's milk and various industrially applied processing methods, i.e., homogenization, fat separation, pasteurization, ultra-heat treatment (UHT), treatment for extended shelf-life (ESL), and conventional boiling...
August 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28858086/association-of-croup-with-asthma-in-children-a-cohort-study
#16
Sheng-Chieh Lin, Hui-Wen Lin, Bor-Luen Chiang
Asthma and croup are common inflammatory airway diseases involving the bronchus in children. However, no study has reported the effects of urbanization, sex, age, and bronchiolitis on the association of croup and its duration with asthma development. We used the Taiwan Longitudinal Health Insurance Database (LHID) to perform this population-based cohort study; here, the cluster effect caused by hospitalization was considered to evaluate the association between croup and asthma development and the risk factors for asthma in children of different age groups...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28852079/cesarean-section-without-medical-indication-and-risks-of-childhood-allergic-disorder-attenuated-by-breastfeeding
#17
Shuyuan Chu, Yunting Zhang, Yanrui Jiang, Wanqi Sun, Qi Zhu, Bin Wang, Fan Jiang, Jun Zhang
Caesarean section (CS) may increase the risk of asthma and allergic diseases in children, but previous studies could not preclude the potential confounding effect of underlying medical indications for CS. We aim to assess the association between CS itself (without indications) and risks of asthma and allergic rhinitis in children. The 2014 Shanghai Children's Health, Education and Lifestyle Evaluation was a large population-based survey with cluster random probability sampling in 26 primary schools in Shanghai, China, in 2014...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833810/features-of-asthma-which-provide-meaningful-insights-for-understanding-the-disease-heterogeneity
#18
Matea Deliu, Tolga S Yavuz, Matthew Sperrin, Danielle Belgrave, Umit M Sahiner, Cansin Sackesen, Omer Kalayci, Adnan Custovic
BACKGROUND: Data-driven methods such as hierarchical clustering (HC) and principal component analysis (PCA) have been used to identify asthma subtypes, with inconsistent results. OBJECTIVE: To develop a framework for the discovery of stable and clinically meaningful asthma subtypes. METHODS: We performed HC in a rich dataset from 613 asthmatic children, using 45 clinical variables (Model 1), and after PCA dimensionality reduction (Model 2)...
August 22, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28815148/spatio-temporal-analysis-for-new-york-state-sparcs-data
#19
Xin Chen, Yu Wang, Elinor Schoenfeld, Mary Saltz, Joel Saltz, Fusheng Wang
Increased accessibility of health data provides unique opportunities to discover spatio-temporal patterns of diseases. For example, New York State SPARCS (Statewide Planning and Research Cooperative System) data collects patient level detail on patient demographics, diagnoses, services, and charges for each hospital inpatient stay and outpatient visit. Such data also provides home addresses for each patient. This paper presents our preliminary work on spatial, temporal, and spatial-temporal analysis of disease patterns for New York State using SPARCS data...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28810589/phenotypic-switch-in-lung-interstitial-macrophage-polarization-in-an-ovalbumin-induced-mouse-model-of-asthma
#20
Hanxiang Nie, Ailing Wang, Qing He, Qiaoyu Yang, Linlin Liu, Guqin Zhang, Yi Huang, Xuhong Ding, Hongying Yu, Suping Hu
Macrophage phenotype and function varies according to their polarized state, which in turn is dependent on microenvironmental stimuli. Under normal physiological conditions, lung interstitial macrophages that express interleukin (IL)-10 are considered to serve regulatory roles in the prevention of allergic reactions in the airways. However, the phenotypic profile of lung interstitial macrophages during the pathophysiology of asthma remains unknown. In the current study, the phenotypic characteristics of lung interstitial macrophages were investigated in an ovalbumin (OVA)-induced mouse model of asthma...
August 2017: Experimental and Therapeutic Medicine
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