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Asthma cluster analysis

Diane Lefaudeux, Bertrand De Meulder, Matthew J Loza, Nancy Peffer, Anthony Rowe, Frédéric Baribaud, Aruna T Bansal, Rene Lutter, Ana R Sousa, Julie Corfield, Ioannis Pandis, Per S Bakke, Massimo Caruso, Pascal Chanez, Sven-Erik Dahlén, Louise J Fleming, Stephen J Fowler, Ildiko Horvath, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandstrom, Dominic E Shaw, Florian Singer, Peter J Sterk, Graham Roberts, Ian M Adcock, Ratko Djukanovic, Charles Auffray, Kian F Chung
BACKGROUND: Asthma is a heterogeneous disease in which there is a differential response to asthma treatments. This heterogeneity needs to be evaluated so that a personalised management approach can be provided. OBJECTIVES: We stratified patients with moderate-to-severe asthma based on clinico-physiological parameters and performed an -omics analysis of sputum. METHODS: Partition-around-medoid clustering was applied to a training set of 266 asthma participants from the European U-BIOPRED adult cohort using 8 pre-specified clinic-physiological variables...
October 20, 2016: Journal of Allergy and Clinical Immunology
Edward M Zoratti, Rebecca Z Krouse, Denise C Babineau, Jacqueline A Pongracic, George T O'Connor, Robert A Wood, Gurjit K Khurana Hershey, Carolyn M Kercsmar, Rebecca S Gruchalla, Meyer Kattan, Stephen J Teach, Steven M Sigelman, Peter J Gergen, Alkis Togias, Cynthia M Visness, William W Busse, Andrew H Liu
BACKGROUND: Children with asthma in low-income urban areas have high morbidity. Phenotypic analysis in these children is lacking, but may identify characteristics to inform successful tailored management approaches. OBJECTIVE: We sought to identify distinct asthma phenotypes among inner-city children receiving guidelines-based management. METHODS: Nine inner-city asthma consortium centers enrolled 717 children aged 6 to 17 years. Data were collected at baseline and prospectively every 2 months for 1 year...
October 2016: Journal of Allergy and Clinical Immunology
Moisés A Calderón, Carmen Vidal, Pablo Rodríguez Del Río, Jocelyne Just, Oliver Pfaar, Ana I Tabar, Inmaculada Sánchez-Machín, Petra Bubel, Jesus Borja, Peter Eberle, Rainer Reiber, Michel Bouvier, Alain Lepelliez, Ludger Klimek, Pascal Demoly
BACKGROUND: Outside clinical trials, data on systemic reactions (SRs) due to allergen immunotherapy (AIT) are scarce. METHODS: A prospective, longitudinal, web-based survey of "real-life" respiratory allergen immunotherapy (AIT) clinical practice was conducted in France, Germany and Spain. SRs were recorded and coded according to the Medical Dictionary for Regulatory Activities (MedDRA) and risk factors associated with SRs were identified. RESULTS: A total of 4,316 patients (corresponding to 4,363 ongoing courses of AIT) were included...
October 8, 2016: Allergy
Amal Al-Garawi, Vincent J Carey, Divya Chhabra, Hooman Mirzakhani, Jarrett Morrow, Jessica Lasky-Su, Weiliang Qiu, Nancy Laranjo, Augusto A Litonjua, Scott T Weiss
BACKGROUND: Patterns of gene expression of human pregnancy are poorly understood. In a trial of vitamin D supplementation in pregnant women, peripheral blood transcriptomes were measured longitudinally on 30 women and used to characterize gene co-expression networks. OBJECTIVE: Studies suggest that increased maternal Vitamin D levels may reduce the risk of asthma in early life, yet the underlying mechanisms have not been examined. In this study, we used a network-based approach to examine changes in gene expression profiles during the course of normal pregnancy and evaluated their association with maternal Vitamin D levels...
2016: PloS One
Duan Wang, Yang Yang, Jin Xu, Zong-Ke Zhou, Hai-Yang Yu
BACKGROUND: It has been reported that the cluster of differentiation 14 (CD14) gene -159C/T variant may be associated with asthma risk. However, some studies yielded conflicting results. Therefore, a comprehensive meta-analysis was designed to assess the precise association. METHODS: A systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI), and Wan fang databases was conducted up to August 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size...
September 2016: Medicine (Baltimore)
Carla Oseroff, Lars H Christensen, Luise Westernberg, John Pham, Jerome Lane, Sinu Paul, Jason Greenbaum, Thomas Stranzl, Gitte Lund, Ilka Hoof, Jens Holm, Peter A Würtzen, Kåre H Meno, April Frazier, Veronique Schulten, Peter S Andersen, Bjoern Peters, Alessandro Sette
BACKGROUND: House dust mite (HDM) allergens are a common cause of allergy and allergic asthma. A comprehensive analysis of proteins targeted by T cells, which are implicated in the development and regulation of allergic disease independent of their antibody reactivity, is still lacking. OBJECTIVE: To comprehensively analyze the HDM-derived protein targets of T cell responses in HDM-allergic individuals, and investigate their correlation with IgE/IgG responses and protein function...
September 29, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Kazuo Nishikawa, Takashi Fujimura, Yasuhiro Ota, Takuya Abe, Kareem Gamal ElRamlawy, Miyako Nakano, Tomoaki Takado, Akira Uenishi, Hidechika Kawazoe, Yoshinori Sekoguchi, Akihiko Tanaka, Kazuhisa Ono, Seiji Kawamoto
BACKGROUND: Environmental control to reduce the amount of allergens in a living place is thought to be important to avoid sensitization to airborne allergens. However, efficacy of environmental control on inactivation of airborne allergens is not fully investigated. We have previously reported that positively- and negatively-charged plasma cluster ions (PC-ions) reduce the IgE-binding capacity of crude allergens from Japanese cedar pollen as important seasonal airborne allergens. Cat (Felis domesticus) and fungus (Aspergillus fumigatus) are also important sources of common airborne allergens in living spaces throughout the year, and early sensitization with those allergens is considered to be a risk factor for future development of allergic rhinitis, pollinosis and asthma...
2016: World Allergy Organization Journal
Youngja H Park, Anne M Fitzpatrick, Carl Angelo Medriano, Dean P Jones
BACKGROUND: Corticosteroid (CS) treatment has been established as the first anti-inflammatory treatment for adults and children with asthma. However, a subset of patients fails to respond to combined systemic and inhaled CS treatment. OBJECTIVE: This study is aimed at further understanding CS resistance among severe asthmatic children. METHODS: High resolution metabolomics (HRM) was performed on urine samples from CS-respondent (n=15) and CS-nonrespondent (n=15) children to determine possible urine biomarkers related to CS resistance...
September 19, 2016: Journal of Allergy and Clinical Immunology
Miguel Germán Borda, Carlos Andrés Celis-Preciado, Mario Ulises Pérez-Zepeda, Julián David Ríos-Zuluaga, Carlos Alberto Cano-Gutiérrez
INTRODUCTION: It has been reported that sarcopenia frequently co-exists with COPD/asthma, and can significantly affect quality of life and the control of chronic diseases. The aim of this study is to describe the association between COPD/asthma and sarcopenia. MATERIAL AND METHODS: Data was used from the SABE-Bogotá study, which included 2,000 older adults aged 60 years or more. It is a cross-probabilistic cluster sample with 81.9% coverage. The dependent variable was COPD/asthma...
September 14, 2016: Revista Española de Geriatría y Gerontología
P Ning, Y F Guo, T Y Sun, H S Zhang, D Chai, X M Li
OBJECTIVE: To study the distinct clinical phenotype of chronic airway diseases by hierarchical cluster analysis and two-step cluster analysis. METHODS: A population sample of adult patients in Donghuamen community, Dongcheng district and Qinghe community, Haidian district, Beijing from April 2012 to January 2015, who had wheeze within the last 12 months, underwent detailed investigation, including a clinical questionnaire, pulmonary function tests, total serum IgE levels, blood eosinophil level and a peak flow diary...
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Chih-Hsi Scott Kuo, Stelios Pavlidis, Matthew Loza, Fred Baribaud, Anthony Rowe, Ioannis Pandis, Uruj Hoda, Christos Rossios, Ana Sousa, Susan J Wilson, Peter Howarth, Barbro Dahlen, Sven-Erik Dahlen, Pascal Chanez, Dominick Shaw, Norbert Krug, Thomas Sandström, Bertrand De Meulder, Diane Lefaudeux, Stephen Fowler, Louise Fleming, Julie Corfield, Charles Auffray, Peter J Sterk, Ratko Djukanovic, Yike Guo, Ian M Adcock, Kian Fan Chung
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies and epithelial brushings of 107 moderate-to-severe asthmatics were annotated by gene-set variation analysis (GSVA) using 42 gene-signatures relevant to asthma, inflammation and immune function. Topological data analysis (TDA) of clinical and histological data was used to derive clusters and the nearest shrunken centroid algorithm used for signature refinement...
August 31, 2016: American Journal of Respiratory and Critical Care Medicine
Cecilie Svanes, Jennifer Koplin, Svein Magne Skulstad, Ane Johannessen, Randi Jakobsen Bertelsen, Byndis Benediktsdottir, Lennart Bråbäck, Anne Elie Carsin, Shyamali Dharmage, Julia Dratva, Bertil Forsberg, Thorarinn Gislason, Joachim Heinrich, Mathias Holm, Christer Janson, Deborah Jarvis, Rain Jögi, Susanne Krauss-Etschmann, Eva Lindberg, Ferenc Macsali, Andrei Malinovschi, Lars Modig, Dan Norbäck, Ernst Omenaas, Eirunn Waatevik Saure, Torben Sigsgaard, Trude Duelien Skorge, Øistein Svanes, Kjell Torén, Carl Torres, Vivi Schlünssen, Francisco Gomez Real
BACKGROUND: Whereas it is generally accepted that maternal environment plays a key role in child health, emerging evidence suggests that paternal environment before conception also impacts child health. We aimed to investigate the association between children's asthma risk and parental smoking and welding exposures prior to conception. METHODS: In a longitudinal, multi-country study, parents of 24 168 offspring aged 2-51 years provided information on their life-course smoking habits, occupational exposure to welding and metal fumes, and offspring's asthma before/after age 10 years and hay fever...
August 25, 2016: International Journal of Epidemiology
Hany Abdel-Aleem, Omaima M H El-Gibaly, Amira F E-S El-Gazzar, Ghada S T Al-Attar
BACKGROUND: The accessibility of health services is an important factor that affects the health outcomes of populations. A mobile clinic provides a wide range of services but in most countries the main focus is on health services for women and children. It is anticipated that improvement of the accessibility of health services via mobile clinics will improve women's and children's health. OBJECTIVES: To evaluate the impact of mobile clinic services on women's and children's health...
2016: Cochrane Database of Systematic Reviews
J Just, C F Elegbede, A Deschildre, J Bousquet, D A Moneret-Vautrin, A Crepet
BACKGROUND: Peanut-allergic reactions are heterogeneous ranging from mild symptoms to anaphylaxis. OBJECTIVE: Identify peanut-allergic/sensitized phenotypes to personalize patient management. METHODS: A combined factor and cluster analysis was used to study the phenotypes of 696 patients diagnosed with peanut sensitization and enrolled in the MIRABEL survey. The method was first applied to the 247 patients with an oral food challenge (OFC)...
August 11, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Stephan Gabet, Jocelyne Just, Rémy Couderc, Jean Bousquet, Nathalie Seta, Isabelle Momas
BACKGROUND: Profiles of allergic sensitisation are poorly documented in infancy. Relations between early sensitisation and allergic morbidity need to be clarified. METHODS: This study dealt with children involved in the Pollution and Asthma Risk: an Infant Study (PARIS), a population-based prospective birth cohort. Allergic sensitisation to 12 food and 4 inhalant allergens was assessed at 18 months and defined by a specific IgE level ≥ 0.35 kUA /L. Health data were collected by standardised questionnaires at 2 and 6 years...
August 8, 2016: Pediatric Allergy and Immunology
X M Gao
This study aimed to predict pathogenic genes of childhood asthma based on molecular interaction networks and gene expression data. Known pathogenic genes identified from the human protein-protein interaction network were denoted as seed genes, and were included in network A. We extracted sub-network B (pathogenic network), which consisted of genes that interacted with at least two seed genes. We assigned a weight to select the pathogenic genes from this network according to its interactions and co-expressions with the seed genes...
2016: Genetics and Molecular Research: GMR
M F Toledo, B M Saraiva-Romanholo, R C Oliveira, P H N Saldiva, L F F Silva, L F C Nascimento, D Solé
BACKGROUND: The prevalence of allergic diseases is increasing. We evaluated temporal trends in the prevalence of asthma, rhinitis and eczema in adolescents (13-14 years) living in Taubaté, SP, Brazil (2005-2012) and assessed the relationship between these prevalences and the residential proximity to Presidente Dutra Highway (PDH, a heavily travelled highway). METHODS: This cross-sectional study of adolescents (N=1039) from public and private schools was evaluated using the standard questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC) plus a question about their place of residence in relation to PDH...
September 2016: Allergologia et Immunopathologia
Geert Rootmensen, Anton van Keimpema, Aeilko Zwinderman, Peter Sterk
BACKGROUND AND OBJECTIVES: Historically, obstructive airway diseases such as asthma and COPD are classified as different diseases. Although the definitions are clearly described, classification of patients into these traditional, clinical disease entity can be difficult. Recent evidence that there are complex, overlapping phenotypes of obstructive lung disease. Our aim was to capture clinical phenotypes of obstructive diseases through the use of cluster analysis in a representative patient population at a common Dutch pulmonary outpatient clinic...
December 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Karen Abernathy, Jingwen Zhang, Patrick Mauldin, William Moran, Mac Abernathy, Elisha Brownfield, Kimberly Davis
OBJECTIVES: Patients with coexisting mental health disorder and chronic disease are more at risk for poor outcomes, including increased acute care utilization. This study was performed to assess the association of mental health disorders on acute care utilization (emergency department [ED] use, hospitalization, and rehospitalization within 30 days) using disease clustering. METHODS: A retrospective cohort analysis was performed on 10 408 patients. Adult patients >18 years of age were included in the study if they were seen at least twice in University Internal Medicine primary care clinic at the Medical University of South Carolina from October 10, 2010 through September 30, 2013...
October 2016: Journal of Primary Care & Community Health
Zhenyu Liang, Laiyu Liu, Haijin Zhao, Yang Xia, Weizhen Zhang, Yanmei Ye, Mei Jiang, Shaoxi Cai
Asthma is considered as a clinical and molecularly heterogeneous disorder. Systemic inflammation is suggested to play an important role in a group of asthma patients. We hypothesized that there is a subgroup of patients with asthma characterized by systemic inflammation. In this study, we aimed to discriminate asthma subtypes based on circulating biomarkers and to determine whether a systemic inflammatory endotype of asthma could be identified. In the present cross-sectional study, 50 patients with untreated asthma were prospectively recruited from a single academic outpatient clinic, and characterized with respect to clinical, functional, and inflammatory parameters...
June 2016: Medicine (Baltimore)
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