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Asthma cluster analysis

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https://www.readbyqxmd.com/read/29663825/clustering-analysis-in-asthmatic-outpatients-an-experience-in-clinical-practice
#1
Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, Fabio Luigi Massimo Ricciardolo
The present real-life study collected medical data from 186 asthmatics with a median age of 40 years. It gathered information on the asthma onset age, allergic rhinitis, comorbidities, smoking, BMI, and severity of respiratory symptoms. Afterwards, ascending hierarchical clustering analysis was performed and outcomes allowed to characterize three different asthma phenotypes. Interestingly, in clustering of asthma patients the most important factor was GINA asthma control scoring corresponding to the asthma control GINA grading...
April 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29656367/the-impact-of-coping-patterns-and-chronic-health-conditions-on-health-related-quality-of-life-among-children-and-adolescents
#2
Sabrina Oppenheimer, Orit Krispin, Sigal Levy, Maayan Ozeri, Alan Apter
This study examined the relationship among chronic disease, coping strategy patterns, and health-related quality of life (HRQOL) among children and adolescents. The cohort included 273 Israeli children and adolescents aged 8-18 years diagnosed with asthma, diabetes mellitus, or celiac disease. All completed the Coping with a Disease Questionnaire (CODI) and the DISABKIDS Chronic Generic Measure (DCGM-37). The outcome measures were as follows: association of the use of effective and non-effective coping strategies with type of disease; predictive value of coping patterns for health-related quality of life; a European sample was used for comparison...
April 14, 2018: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29626164/neighborhood-child-opportunity-and-individual-level-pediatric-acute-care-use-and-diagnoses
#3
Ellen E Kersten, Nancy E Adler, Laura Gottlieb, Douglas P Jutte, Sarah Robinson, Katrina Roundfield, Kaja Z LeWinn
: media-1vid110.1542/5751513300001PEDS-VA_2017-2309 Video Abstract OBJECTIVES: Although health care providers and systems are increasingly interested in patients' nonmedical needs as a means to improve health, little is known about neighborhood conditions that contribute to child health problems. We sought to determine if a novel, publicly available measure of neighborhood context, the Child Opportunity Index, was associated with pediatric acute care visit frequency and diagnoses. METHODS: This cross-sectional study included San Francisco residents <18 years of age with an emergency department and/or urgent care visit to any of 3 medical systems ( N = 47 175) between 2007 and 2011...
April 6, 2018: Pediatrics
https://www.readbyqxmd.com/read/29605212/prevalence-and-risk-factors-of-asthma-in-mainland-china-the-care-study
#4
Jiangtao Lin, Wenya Wang, Ping Chen, Xin Zhou, Huanying Wan, Kaisheng Yin, Lijun Ma, Changgui Wu, Jing Li, Chuntao Liu, Nan Su, Guoliang Liu, Hua Xie, Wei Tang, Mao Huang, Yan Chen, Yuanhua Liu, Liqiang Song, Xianliang Chen, Yongming Zhang, Wen Li, Lichao Sun
BACKGROUND: There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China. OBJECTIVES: The CARE survey aims to demonstrate the prevalence and risk factors of asthma in mainland China among adolescents (age >14 years) and adults. METHODS: The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29602481/-asthma-adapting-the-therapeutic-follow-up-according-to-the-medical-and-psychosocial-profiles
#5
A Deccache, A Didier, P Mayran, A Jeziorski, C Raherison
INTRODUCTION: This work is based on the data of REALISE™, a survey conducted among 8000 European patients to identify the profiles of adult asthma patients and how these are linked with treatment adherence behaviors. METHODS: A cluster analysis was performed by combining data in three ways: control of asthma, attitude towards the disease, compliance with treatment. A multidisciplinary group analyzed the results for the 1024 French survey respondents. RESULTS: Four patient profiles were identified: "rather confident" (28% of patients), rather young patients with a low level of concern about their asthma...
March 27, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29601354/phenotypes-endotypes-driven-treatment-in-asthma
#6
Fulvio Braido, Angelica Tiotiu, Krzysztof Kowal, Stefan Mihaicuta, Plamena Novakova, Ipek Kivilcim Oguzulgen
PURPOSE OF REVIEW: Target therapy is the necessary step towards personalized medicine. The definition of asthma phenotypes and underlying mechanisms (endotypes) represent a key point in the development of new asthma treatments. Big data analysis, biomarker research and the availability of monoclonal antibodies, targeting specific cytokines is leading to the rapid evolution of knowledge. In this review, we sought to outline many of the recent advances in the field. RECENT FINDINGS: Several attempts have been made to identify asthma phenotypes, sometimes with contrasting results...
March 29, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29574758/childhood-asthma-clusters-reveal-neutrophil-predominant-phenotype-with-distinct-gene-expression
#7
Ming-Wei Su, Wen-Chang Lin, Ching-Hui Tsai, Bor-Luen Chiang, Yao-Hsu Yang, Yu-Tsan Lin, Li-Chieh Wang, Jyh-Hong Lee, Chen-Cheng Chou, Yi-Fan Wu, Yu-Liang Yeh, Yungling L Lee
BACKGROUND: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments. METHODS: We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene expression profiles of peripheral blood mononuclear cells (PBMC) from children with different asthma phenotypes...
March 25, 2018: Allergy
https://www.readbyqxmd.com/read/29550710/chemical-profiling-and-quantitation-of-bioactive-compounds-in-platycladi-cacumen-by-uplc-q-tof-ms-ms-and-uplc-dad
#8
Bo Zhuang, Zhi-Ming Bi, Zi-Yuan Wang, Li Duan, Chang-Jiang-Sheng Lai, E-Hu Liu
Platycladi Cacumen (PC) is a traditional Chinese medicine used for the treatment of hemorrhages, cough, asthma and hair loss. To get a better understanding of the chemical constituents in PC, ultra-high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) and diagnostic ion filtering strategy were firstly employed for chemical profiling of PC. A total of 43 compounds including organic acids and derivatives, flavonoids as well as phenylpropanolds were unambiguously or reasonably identified...
March 9, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29550052/airway-pathological-heterogeneity-in-asthma-visualization-of-disease-microclusters-using-topological-data-analysis
#9
Salman Siddiqui, Aarti Shikotra, Matthew Richardson, Emma Doran, David Choy, Alex Bell, Cary D Austin, Jeffrey Eastham-Anderson, Beverley Hargadon, Joseph R Arron, Andrew Wardlaw, Christopher E Brightling, Liam G Heaney, Peter Bradding
BACKGROUND: Asthma is a complex chronic disease underpinned by pathological changes within the airway wall. How variations in structural airway pathology and cellular inflammation contribute to the expression and severity of asthma are poorly understood. OBJECTIVES: Therefore we evaluated pathological heterogeneity using topological data analysis (TDA) with the aim of visualizing disease clusters and microclusters. METHODS: A discovery population of 202 adult patients (142 asthmatic patients and 60 healthy subjects) and an external replication population (59 patients with severe asthma) were evaluated...
March 7, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29545275/multimorbidity-medications-and-poor-asthma-prognosis
#10
Sébastien Chanoine, Margaux Sanchez, Isabelle Pin, Sofia Temam, Nicole Le Moual, Agnès Fournier, Christophe Pison, Jean Bousquet, Pierrick Bedouch, Marie-Christine Boutron-Ruault, Raphaëlle Varraso, Valérie Siroux
Multi-medication related to multimorbidity is common in the elderly with asthma. We aimed at comprehensively characterizing medications used by elderly women, and assessing how multi-medication impacts on asthma prognosis.We performed network-based analyses on drug administrative databases to visualize the prevalence of drug classes and their interconnections among 17,458 elderly women from the Asthma-E3N study, including 4,328 women with asthma. Asthma groups sharing similar medication profiles were identified by clustering method relying on all medications and were studied in association with adverse asthma events (uncontrolled asthma, attacks/exacerbations, and poor asthma-related quality of life)...
March 15, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29531100/use-of-asthma-apgar-tools-in-primary-care-practices-a-cluster-randomized-controlled-trial
#11
Barbara P Yawn, Peter C Wollan, Matthew A Rank, Susan L Bertram, Young Juhn, Wilson Pace
PURPOSE: The purpose of this study was to assess patient and practice outcomes after introducing the Asthma APGAR (Activities, Persistent, triGGers, Asthma medications, Response to therapy) tools into primary care practices. METHODS: We used a pragmatic cluster-randomized controlled design in 18 US family medicine and pediatric practices to compare outcomes in patients with persistent asthma aged 5 to 45 years after introduction of the Asthma APGAR tools vs usual care...
March 2018: Annals of Family Medicine
https://www.readbyqxmd.com/read/29526967/a-cluster-analysis-of-bronchial-asthma-patients-with-depressive-symptoms
#12
Yo Seino, Takashi Hasegawa, Toshiyuki Koya, Takuro Sakagami, Ichiro Mashima, Natsue Shimizu, Yoshiyuki Muramatsu, Kumiko Muramatsu, Eiichi Suzuki, Toshiaki Kikuchi
Objective Whether or not depression affects the control or severity of asthma is unclear. We performed a cluster analysis of asthma patients with depressive symptoms to clarify their characteristics. Methods and subjects Multiple medical institutions in Niigata Prefecture, Japan, were surveyed in 2014. We recorded the age, disease duration, body mass index (BMI), medications, and surveyed asthma control status and severity, as well as depressive symptoms and adherence to treatment using questionnaires. A hierarchical cluster analysis was performed on the group of patients assessed as having depression...
March 9, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29524252/early-food-allergy-and-respiratory-allergy-symptoms-and-attention-deficit-hyperactivity-disorder-in-chinese-children-a-cross-sectional-study
#13
Xiaodong Jiang, Chun Shen, Yuan Dai, Fan Jiang, Shenghui Li, Xiaoming Shen, Yan Hu, Fei Li
BACKGROUND: The relationship between food allergy and respiratory allergy, and attention-deficit/hyperactivity disorder (ADHD) in children is rarely investigated. Our objective is to determine whether early food allergy and respiratory allergy symptoms are associated with the prevalence of ADHD in Chinese school-age children. METHODS: This cross-sectional study was conducted in school-age children using cluster-stratified methods from nine cities across China between November and December 2005...
March 9, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29512854/contribution-of-repeated-infections-in-asthma-persistence-from-preschool-to-school-age-design-and-characteristics-of-the-predicta-cohort
#14
Paraskevi Xepapadaki, Claus Bachert, Susetta Finotto, Tuomas Jartti, George N Konstantinou, Alexander Kiefer, Marek Kowalski, Anna Lewandowska-Polak, Heikki Lukkarinen, Eirini Roumpedaki, Anna Sobanska, Ina Sintobin, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G Papadopoulos
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association to viral/microbial exposures and immunological responses. We present the cohort design, demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls...
March 7, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29509764/multimorbidity-and-survival-for-patients-with-acute-myocardial-infarction-in-england-and-wales-latent-class-analysis-of-a-nationwide-population-based-cohort
#15
Marlous Hall, Tatendashe B Dondo, Andrew T Yan, Mamas A Mamas, Adam D Timmis, John E Deanfield, Tomas Jernberg, Harry Hemingway, Keith A A Fox, Chris P Gale
BACKGROUND: There is limited knowledge of the scale and impact of multimorbidity for patients who have had an acute myocardial infarction (AMI). Therefore, this study aimed to determine the extent to which multimorbidity is associated with long-term survival following AMI. METHODS AND FINDINGS: This national observational study included 693,388 patients (median age 70.7 years, 452,896 [65.5%] male) from the Myocardial Ischaemia National Audit Project (England and Wales) who were admitted with AMI between 1 January 2003 and 30 June 2013...
March 2018: PLoS Medicine
https://www.readbyqxmd.com/read/29420086/a-review-of-obesity-and-asthma-across-the-life-span
#16
Faiza Khalid, Fernando Holguin
OBJECTIVE: This literature review aims to compare obese-asthmatic adults and children, and to characterize differences and similarities between the two subgroups from epidemiological, demographical, phenotypical, and physiological perspectives. METHODS: Literature search was conducted using Pubmed database with "obesity," "asthma," "epidemiology," "cluster analysis," "demography," "mechanics," and ''FeNO'' as search terms...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29385434/importance-of-comorbidities-in-the-treatment-of-primary-care-patients-with-heart-failure-baseline-results-of-the-observational-recode-hf-study
#17
Marion Eisele, Winfried Adam, Anja Rakebrandt, Sigrid Boczor, Eva Blozik, Jens-Martin Träder, Stefan Störk, Christoph Herrmann-Lingen, Martin Scherer
Background: Both non-cardiac and cardiac comorbidities are related to the prognosis of chronic heart failure (HF), but so far little is known about the impact of comorbidities on treatment difficulties in routine care. Objectives: To investigate which comorbidities are associated with treatment difficulties in primary care. We hypothesized that somatic comorbidities as well as psychosocial distress are associated with treatment difficulties. Methods: In this baseline analysis of data of the observational RECODE-HF study, HF patients were recruited via primary care practices in two German sites...
January 29, 2018: Family Practice
https://www.readbyqxmd.com/read/29356659/proximity-to-two-main-sources-of-industrial-outdoor-air-pollution-and-emergency-department-visits-for-childhood-asthma-in-edmonton-canada
#18
Laura A Rodriguez-Villamizar, Rhonda J Rosychuk, Alvaro Osornio-Vargas, Paul J Villeneuve, Brian H Rowe
OBJECTIVE: Children are recognized to be more susceptible than healthy adults to the effects of air pollution; however, relatively few Canadian studies of children have focused on industrial emissions. We conducted a spatial cross-sectional study to explore associations between emergency department (ED) visits for childhood asthma and residential proximity to two industrial sources of air pollution (coal-fired power plant and petrochemical industry) in Edmonton, Canada. METHODS: Using administrative health care data for Alberta between 2004 and 2010, we conducted a spatial analysis of disease clusters of count data around these two industrial sources...
January 22, 2018: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29326334/clinical-and-inflammatory-phenotyping-by-breathomics-in-chronic-airway-diseases-irrespective-of-the-diagnostic-label
#19
Rianne de Vries, Yennece W F Dagelet, Pien Spoor, Erik Snoey, Patrick M C Jak, Paul Brinkman, Erica Dijkers, Simon K Bootsma, Fred Elskamp, Frans H C de Jongh, Eric G Haarman, Johannes C C M In 't Veen, Anke-Hilse Maitland-van der Zee, Peter J Sterk
Asthma and chronic obstructive pulmonary disease (COPD) are complex and overlapping diseases that include inflammatory phenotypes. Novel anti-eosinophilic/anti-neutrophilic strategies demand rapid inflammatory phenotyping, which might be accessible from exhaled breath.Our objective was to capture clinical/inflammatory phenotypes in patients with chronic airway disease using an electronic nose (eNose) in a training and validation set.This was a multicentre cross-sectional study in which exhaled breath from asthma and COPD patients (n=435; training n=321 and validation n=114) was analysed using eNose technology...
January 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29325544/prevalence-and-associated-factors-of-wheezing-illnesses-of-children-aged-three-to-five-years-living-in-under-served-settlements-of-the-colombo-municipal-council-in-sri-lanka-a-cross-sectional-study
#20
Ruwanika Seneviratne, Nalika S Gunawardena
BACKGROUND: A rising trend in Sri Lanka for asthma and wheezing illness is observed with higher morbidity in younger children and a paucity of related research. 'Under-served settlements' (USS) of Colombo Municipal Council (CMC) have poor living environments conducive to childhood wheezing. The objective was to describe the prevalence and associated factors of wheezing illnesses of three to five year old children living in low-income settlements in CMC. METHODS: A cross-sectional study was conducted on 460 three to five year old children and their caregivers using cluster sampling among residents of two randomly selected USSs of CMC...
January 11, 2018: BMC Public Health
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