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Asthma cluster analysis

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https://www.readbyqxmd.com/read/28346028/prevalence-and-associated-factors-for-self-reported-asthma-in-a-canadian-population-the-canadian-community-health-survey-2014
#1
Luan M Chu, Punam Pahwa
BACKGROUND: Asthma prevalence is increasing among adults, yet limited information regarding the association between adult asthma and environmental and personal exposures is available using large nationally representative population-based survey. OBJECTIVE: To determine the prevalence of asthma and associated factors for self-reported asthma in a Canadian population aged 12 years and older by using the Canadian Community Health Survey (CCHS) 2014 cross-sectional cohort...
March 27, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28319180/effect-of-outdoor-air-pollution-on-asthma-exacerbations-in-children-and-adults-systematic-review-and-multilevel-meta-analysis
#2
Pablo Orellano, Nancy Quaranta, Julieta Reynoso, Brenda Balbi, Julia Vasquez
BACKGROUND: Several observational studies have suggested that outdoor air pollution may induce or aggravate asthma. However, epidemiological results are inconclusive due to the presence of numerous moderators which influence this association. The goal of this study was to assess the relationship between outdoor air pollutants and moderate or severe asthma exacerbations in children and adults through a systematic review and multilevel meta-analysis. MATERIAL AND METHODS: We searched studies published in English on PubMed, Scopus, and Google Scholar between January 2000 and October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28318759/asthma-education-taught-by-physical-education-teachers-at-grade-schools-a-randomised-cluster-trial
#3
M Praena-Crespo, N Aquino-Llinares, J C Fernández-Truan, L Castro-Gómez, C Segovia-Ferrera
OBJECTIVE: Assess whether the Asthma, Sport and Health (ASAH) programme taught by teachers improves asthmatics' quality of life, asthma knowledge, and reduces school absenteeism. DESIGN: Randomised cluster trial parallel group. PARTICIPANTS: 2293 students (203 asthmatic) in the Intervention School group (IS) and 2214 in the Comparison School (CS) (224 asthmatic) belonging to primary school. INTERVENTION: Implementation of the educational programme "Asthma, Sport and Health" at grade schools, taught by physical education teachers...
March 15, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28298259/phenotypic-analysis-of-asthma-in-japanese-athletes
#4
Keisuke Tsukioka, Toshiyuki Koya, Hiroshi Ueno, Masachika Hayashi, Takuro Sakagami, Takashi Hasegawa, Masaaki Arakawa, Eiichi Suzuki, Toshiaki Kikuchi
BACKGROUND: Asthma in athlete populations such as Olympic athletes has various pathogeneses. However, few reports are available on the features of asthma in the athlete population in clinical practice. In this study, we focused on classifying asthma in Japanese athlete population. METHODS: We performed a cluster analysis of data from pulmonary function tests and clinical biomarkers before administering inhaled corticosteroids (ICS) therapy in athlete population of individuals diagnosed with asthma (n = 104; male, 76...
March 12, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28293414/galectin-3-an-early-predictive-biomarker-of-modulation-of-airway-remodeling-in-patients-with-severe-asthma-treated-with-omalizumab-for-36%C3%A2-months
#5
Anna Maria Riccio, Pierluigi Mauri, Laura De Ferrari, Rossana Rossi, Dario Di Silvestre, Louise Benazzi, Alessandra Chiappori, Roberto Walter Dal Negro, Claudio Micheletto, Giorgio Walter Canonica
BACKGROUND: Bronchial asthma is a heterogeneous disease characterized by three cardinal features: chronic inflammation, variable airflow obstruction, and airway hyperresponsiveness. Asthma has traditionally been defined using nonspecific clinical and physiologic variables that encompass multiple phenotypes and are treated with nonspecific anti-inflammatory therapies. Based on the modulation of airway remodeling after 12 months of anti-immunoglobulin E (IgE) treatment, we identified two phenotypes (omalizumab responder, OR; and non-omalizumab responder, NOR) and performed morphometric analysis of bronchial biopsy specimens...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28288272/interventions-to-improve-inhaler-technique-for-people-with-asthma
#6
REVIEW
Rebecca Normansell, Kayleigh M Kew, Alexander G Mathioudakis
BACKGROUND: Asthma is a common chronic disease worldwide. Inhalers are often prescribed to help control asthma symptoms, improve quality of life and reduce the risk of exacerbations or flare-ups. However, evidence suggests that many people with asthma do not use their inhaler correctly. It is therefore important to evaluate whether interventions aimed specifically at improving technique are effective and safe, and whether use of these interventions translates into improved clinical outcomes...
March 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28283935/application-of-multivariate-statistical-analysis-in-the-pollution-and-health-risk-of-traffic-related-heavy-metals
#7
Mohammad Ebqa'ai, Bashar Ibrahim
This study aims to analyse the heavy metal pollutants in Jeddah, the second largest city in the Gulf Cooperation Council with a population exceeding 3.5 million, and many vehicles. Ninety-eight street dust samples were collected seasonally from the six major roads as well as the Jeddah Beach, and subsequently digested using modified Leeds Public Analyst method. The heavy metals (Fe, Zn, Mn, Cu, Cd, and Pb) were extracted from the ash using methyl isobutyl ketone as solvent extraction and eventually analysed by atomic absorption spectroscopy...
March 10, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28278278/dynamic-changes-of-the-respiratory-microbiota-and-its-relationship-to-fecal-and-blood-microbiota-in-healthy-young-cats
#8
Aida I Vientós-Plotts, Aaron C Ericsson, Hansjorg Rindt, Megan E Grobman, Amber Graham, Kaitlin Bishop, Leah A Cohn, Carol R Reinero
Advances in the field of metagenomics using culture-independent methods of microbial identification have allowed characterization of rich and diverse communities of bacteria in the lungs of healthy humans, mice, dogs, sheep and pigs. These data challenge the long held belief that the lungs are sterile and microbial colonization is synonymous with pathology. Studies in humans and animals demonstrate differences in the composition of airway microbiota in health versus disease suggesting respiratory dysbiosis occurs...
2017: PloS One
https://www.readbyqxmd.com/read/28275137/a-ceacam6-high-airway-neutrophil-phenotype-and-ceacam6-high-epithelial-cells-are-features-of-severe-asthma
#9
Aarti Shikotra, David F Choy, Salman Siddiqui, Greer Arthur, Deepti R Nagarkar, Guiquan Jia, Adam K A Wright, Chandra M Ohri, Emma Doran, Claire A Butler, Beverley Hargadon, Alexander R Abbas, Janet Jackman, Lawren C Wu, Liam G Heaney, Joseph R Arron, Peter Bradding
Severe asthma represents a major unmet clinical need; understanding the pathophysiology is essential for the development of new therapies. Using microarray analysis, we previously found three immunological clusters in asthma: Th2-high, Th17-high, and Th2/17-low. Although new therapies are emerging for Th2-high disease, identifying molecular pathways in Th2-low disease remains an important goal. Further interrogation of our previously described microarray dataset revealed upregulation of gene expression for carcinoembryonic Ag cell adhesion molecule (CEACAM) family members in the bronchi of patients with severe asthma...
March 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28179442/t-helper-cell-type-2-th2-and-non-th2-molecular-phenotypes-of-asthma-using-sputum-transcriptomics-in-u-biopred
#10
Chih-Hsi Scott Kuo, Stelios Pavlidis, Matthew Loza, Fred Baribaud, Anthony Rowe, Iaonnis Pandis, Ana Sousa, Julie Corfield, Ratko Djukanovic, Rene Lutter, Peter J Sterk, Charles Auffray, Yike Guo, Ian M Adcock, Kian Fan Chung
Asthma is characterised by heterogeneous clinical phenotypes. Our objective was to determine molecular phenotypes of asthma by analysing sputum cell transcriptomics from 104 moderate-to-severe asthmatic subjects and 16 nonasthmatic subjects.After filtering on the differentially expressed genes between eosinophil- and noneosinophil-associated sputum inflammation, we used unbiased hierarchical clustering on 508 differentially expressed genes and gene set variation analysis of specific gene sets.We defined three transcriptome-associated clusters (TACs): TAC1 (characterised by immune receptors IL33R, CCR3 and TSLPR), TAC2 (characterised by interferon-, tumour necrosis factor-α- and inflammasome-associated genes) and TAC3 (characterised by genes of metabolic pathways, ubiquitination and mitochondrial function)...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28143694/quantitative-computed-tomographic-imaging-based-clustering-differentiates-asthmatic-subgroups-with-distinctive-clinical-phenotypes
#11
Sanghun Choi, Eric A Hoffman, Sally E Wenzel, Mario Castro, Sean Fain, Nizar Jarjour, Mark L Schiebler, Kun Chen, Ching-Long Lin
BACKGROUND: Imaging variables, including airway diameter, wall thickness, and air trapping, have been found to be important metrics when differentiating patients with severe asthma from those with nonsevere asthma and healthy subjects. OBJECTIVE: The objective of this study was to identify imaging-based clusters and to explore the association of the clusters with existing clinical metrics. METHODS: We performed an imaging-based cluster analysis using quantitative computed tomography-based structural and functional variables extracted from the respective inspiration and expiration scans of 248 asthmatic patients...
January 29, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28140482/phenotypical-characterization-of-peanut-allergic-children-with-differences-in-cross-allergy-to-tree-nuts-and-other-legumes
#12
Mathias Cousin, Stéphane Verdun, Maxime Seynave, Anne-Christine Vilain, Amélie Lansiaux, Anne Decoster, Christine Sauvage
BACKGROUND: Peanut allergy in children is often associated with allergies to tree nuts and/or legumes. The aim of the present study was to analyze in cluster a cohort of children allergic to peanuts and assessed for cross-reactivity to nuts and legumes and to identify different phenotypes. METHODS: We included retrospectively 317 children with peanut allergy evaluated at the Allergy Unit of the Saint Vincent Hospital of Lille in the last 12 years. A complete work-up for peanut allergy and nuts and legumes was carried out for each patient...
January 31, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28125150/phenotypes-of-asthma-in-low-income-children-and-adolescents-cluster-analysis
#13
Anna Lucia Barros Cabral, Andrey Wirgues Sousa, Felipe Augusto Rodrigues Mendes, Celso Ricardo Fernandes de Carvalho
Objective: Studies characterizing asthma phenotypes have predominantly included adults or have involved children and adolescents in developed countries. Therefore, their applicability in other populations, such as those of developing countries, remains indeterminate. Our objective was to determine how low-income children and adolescents with asthma in Brazil are distributed across a cluster analysis. Methods: We included 306 children and adolescents (6-18 years of age) with a clinical diagnosis of asthma and under medical treatment for at least one year of follow-up...
January 23, 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28116096/an-inhaled-dose-of-budesonide-induces-genes-involved-in-transcription-and-signaling-in-the-human-airways-enhancement-of-anti-and-proinflammatory-effector-genes
#14
Richard Leigh, Mahmoud M Mostafa, Elizabeth M King, Christopher F Rider, Suharsh Shah, Curtis Dumonceaux, Suzanne L Traves, Andrew McWhae, Tyler Kolisnik, Cora Kooi, Donna M Slater, Margaret M Kelly, Mark Bieda, Anna Miller-Larsson, Robert Newton
Although inhaled glucocorticoids, or corticosteroids (ICS), are generally effective in asthma, understanding their anti-inflammatory actions in vivo remains incomplete. To characterize glucocorticoid-induced modulation of gene expression in the human airways, we performed a randomized placebo-controlled crossover study in healthy male volunteers. Six hours after placebo or budesonide inhalation, whole blood, bronchial brushings, and endobronchial biopsies were collected. Microarray analysis of biopsy RNA, using stringent (≥2-fold, 5% false discovery rate) or less stringent (≥1...
August 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28110382/economic-evaluations-alongside-efficient-study-designs-using-large-observational-datasets-the-pleasant-trial-case-study
#15
Matthew Franklin, Sarah Davis, Michelle Horspool, Wei Sun Kua, Steven Julious
BACKGROUND: Large observational datasets such as Clinical Practice Research Datalink (CPRD) provide opportunities to conduct clinical studies and economic evaluations with efficient designs. OBJECTIVES: Our objectives were to report the economic evaluation methodology for a cluster randomised controlled trial (RCT) of a UK NHS-delivered public health intervention for children with asthma that was evaluated using CPRD and describe the impact of this methodology on results...
January 21, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28049188/association-of-polysensitization-allergic-multimorbidity-and-allergy-severity-a-cross-sectional-study-of-school-children
#16
Eun Kyo Ha, Ji Hyeon Baek, So-Yeon Lee, Yong Mean Park, Woo Kyung Kim, Youn Ho Sheen, Seung Jin Lee, Youngoh Bae, Jihyeon Kim, Kee-Jae Lee, Kangmo Ahn, Ho-Jang Kwon, Man Yong Han
BACKGROUND: Aeroallergen sensitization is related to the coexistence of allergic diseases, but the nature of this relationship is poorly understood. The aim of this study was to clarify the relationship of polysensitization with allergic multimorbidities and the severity of allergic diseases. METHODS: This study is a cross-sectional analysis of 3,368 Korean children aged 6-7 years-old. We defined IgE-mediated allergic diseases based on structured questionnaires, and classified the sensitivity to 18 aeroallergens by logistic regression and the Ward hierarchical clustering method...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28049124/personalised-medicine-in-asthma-from-curative-to-preventive-medicine
#17
REVIEW
Laurent Guilleminault, Hakima Ouksel, Chantal Belleguic, Yannick Le Guen, Patrick Germaud, Emilie Desfleurs, Christophe Leroyer, Antoine Magnan
The concept of asthma has changed substantially in recent years. Asthma is now recognised as a heterogeneous entity that is complex to treat. The subdivision of asthma, provided by "cluster" analyses, has revealed various groups of asthma patients who share phenotypic features. These phenotypes underlie the need for personalised asthma therapy because, in contrast to the previous approach, treatment must be tailored to the individual patient. Determination of the patient's asthma phenotype is therefore essential but sometimes challenging, particularly in elderly patients with a multitude of comorbidities and a complex exposure history...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28011367/biomarkers-associated-with-disease-severity-in-allergic-and-nonallergic-asthma
#18
Selene Baos, David Calzada, Lucía Cremades, Joaquín Sastre, Joaquín Quiralte, Fernando Florido, Carlos Lahoz, Blanca Cárdaba
Asthma is a complex, chronic respiratory disease with a wide clinical spectrum. Use of high-throughput technologies has generated a great deal of data that require validation. In this work the objective was to validate molecular biomarkers related to asthmatic disease types in peripheral blood samples and define their relationship with disease severity. With this purpose, ninety-four previously described genes were analyzed by qRT-PCR in 30 healthy control (HC) subjects, 30 patients with nonallergic asthma (NA), 30 with allergic asthma (AA), and 14 patients with allergy (rhinitis) but without asthma (AR)...
February 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28005003/pleasant-preventing-and-lessening-exacerbations-of-asthma-in-school-age-children-associated-with-a-new-term-a-cluster-randomised-controlled-trial-and-economic-evaluation
#19
Steven A Julious, Michelle J Horspool, Sarah Davis, Mike Bradburn, Paul Norman, Neil Shephard, Cindy L Cooper, W Henry Smithson, Jonathan Boote, Heather Elphick, Amanda Loban, Matthew Franklin, Wei Sun Kua, Robin May, Jennifer Campbell, Rachael Williams, Saleema Rex, Oscar Bortolami
BACKGROUND: Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma episodes in school-aged children associated with the return to school following the summer vacation. A fall in prescription collection in the month of August has been observed, and was associated with an increase in the number of unscheduled contacts after the return to school in September. OBJECTIVE: The primary objective of the study was to assess whether or not a NHS-delivered public health intervention reduces the September peak in unscheduled medical contacts...
December 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27978840/validated-and-longitudinally-stable-asthma-phenotypes-based-on-cluster-analysis-of-the-adept-study
#20
Matthew J Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S Barnathan, Vedrana S Susulic, Philip E Silkoff, Peter J Sterk, Frédéric Baribaud
BACKGROUND: Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED. METHODS: Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available...
December 15, 2016: Respiratory Research
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