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Asthma cluster analysis

Feng-Chiao Su, Melissa C Friesen, Aleksandr B Stefaniak, Paul K Henneberger, Ryan F LeBouf, Marcia L Stanton, Xiaoming Liang, Michael Humann, M Abbas Virji
Objectives: Use of cleaning and disinfecting products is associated with work-related asthma among healthcare workers, but the specific levels and factors that affect exposures remain unclear. The objective of this study was to evaluate the determinants of selected volatile organic compound (VOC) exposures in healthcare settings. Methods: Personal and mobile-area air measurements (n = 143) from 100 healthcare workers at four hospitals were used to model the determinants of ethanol, acetone, 2-propanol, d-limonene, α-pinene, and chloroform exposures...
June 21, 2018: Annals of Work Exposures and Health
Rachel S Kelly, Bo L Chawes, Kevin Blighe, Yamini V Virkud, Damien C Croteau-Chonka, Michael J McGeachie, Clary B Clish, Kevin Bullock, Juan C Celedón, Scott T Weiss, Jessica A Lasky-Su
BACKGROUND: Single-omic analyses have provided some insight into the basis of lung function in asthmatic children, but the underlying biological pathways are still poorly understood. METHODS: Weighted gene co-expression network analysis (WGCNA) was used to identify modules of co-regulated gene transcripts and metabolites in blood, among 325 children with asthma from the 'Genetic Epidemiology of Asthma in Costa Rica' study. The biology of modules associated with lung function; as measured by FEV1 , FEV1 /FVC-ratio, bronchodilator response, and airway responsiveness to methacholine, was explored...
June 13, 2018: Chest
Zala Jevnikar, Jörgen Östling, Elisabeth Ax, Jenny Calvén, Kristofer Thörn, Elisabeth Israelsson, Lisa Öberg, Akul Singhania, Laurie C K Lau, Susan J Wilson, Jonathan A Ward, Anoop Chauhan, Ana R Sousa, Bertrand De Meulder, Matthew J Loza, Frédéric Baribaud, Peter J Sterk, Kian Fan Chung, Kai Sun, Yike Guo, Ian M Adcock, Debbie Payne, Barbro Dahlen, Pascal Chanez, Dominick E Shaw, Norbert Krug, Jens M Hohlfeld, Thomas Sandström, Ratko Djukanovic, Anna James, Timothy S C Hinks, Peter H Howarth, Outi Vaarala, Marleen van Geest, Henric K Olsson
BACKGROUND: Although several studies link high levels of IL-6 and soluble IL-6 receptor (sIL-6R) with asthma severity and decreased lung function, the role of IL-6 trans-signaling (IL-6TS) in asthma is unclear. OBJECTIVE: To explore the association between epithelial IL-6TS pathway activation and molecular and clinical phenotypes in asthma. METHODS: An IL-6TS gene signature, obtained from air-liquid interface (ALI) cultures of human bronchial epithelial cells stimulated with IL-6 and sIL-6R, was used to stratify lung epithelium transcriptomic data (U-BIOPRED cohorts) by hierarchical clustering...
June 11, 2018: Journal of Allergy and Clinical Immunology
Dilsad Mungan, Omur Aydin, Bassam Mahboub, Mohammad Albader, Hesham Tarraf, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma affects millions worldwide resulting in a significant disease burden. However, data on asthma burden from the Middle East is limited. This analysis describes the asthma burden in Egypt, Turkey and a Gulf cluster (Kuwait, Saudi Arabia and United Arab Emirates) as part of the SNAPSHOT program. METHODS: SNAPSHOT was an observational, cross-sectional program carried out by telephone in a random sample of the adult general population of the five above mentioned countries...
June 2018: Respiratory Medicine
Dawit T Zemedikun, Laura J Gray, Kamlesh Khunti, Melanie J Davies, Nafeesa N Dhalwani
OBJECTIVE: To assess the prevalence, disease clusters, and patterns of multimorbidity using a novel 2-stage approach in middle-aged and older adults from the United Kingdom. PATIENTS AND METHODS: Data on 36 chronic conditions from 502,643 participants aged 40 to 69 years with baseline measurements between March 13, 2006, and October 1, 2010, from the UK Biobank were extracted. We combined cluster analysis and association rule mining to assess patterns of multimorbidity overall and by age, sex, and ethnicity...
May 22, 2018: Mayo Clinic Proceedings
B Wei, F Liu, J Zhang, Y Liu, J Du, S Liu, N Zhang, C Bachert, J Meng
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a challenging clinical problem due to its propensity for recurrence. However, data on the frequency of CRSwNP recurrence after surgery in China are rare. METHODS: 78 CRSwNP patients undergoing functional endoscopic sinus surgery were followed-up for 8 years and classified into recurrent and non-recurrent groups. A cluster analysis of the CRSwNP based on inflammatory endotypes was performed, and the endotypes were secondarily matched with clinical phenotypes...
May 22, 2018: Rhinology
Hesham Tarraf, Omur Aydin, Dilsad Mungan, Mohammad Albader, Bassam Mahboub, Adam Doble, Aaicha Lahlou, Luqman Tariq, Fayaz Aziz, Abdelkader El Hasnaoui
BACKGROUND: Asthma is a common chronic respiratory disease leading to morbidity, mortality and impaired quality of life worldwide. Information on asthma prevalence in the Middle East is fragmented and relatively out-dated. The SNAPSHOT program was conducted to obtain updated information. METHODS: SNAPSHOT is a cross-sectional epidemiological program carried out in five Middle Eastern countries (Egypt, Turkey, Kuwait, Saudi Arabia, and the United Arab Emirates, the latter three grouped into a Gulf cluster) to collect data on asthma, allergic rhinitis, benign prostatic hyperplasia and bipolar disorder...
May 11, 2018: BMC Pulmonary Medicine
Alayne D Markland, Camille P Vaughan, Ike S Okosun, Patricia S Goode, Kathryn L Burgio, Theodore M Johnson
OBJECTIVE: To identify patterns of prevalent chronic medical conditions among women with urinary incontinence (UI). MATERIALS AND METHODS: We combined cross-sectional data from the 2005-2006 to 2011-2012 US National Health and Nutrition Examination Surveys, and identified 3 800 women with UI and data on 12 chronic conditions. Types of UI included stress UI (SUI), urgency UI (UUI), and mixed stress and urgency UI (MUI). We categorized UI as mild, moderate or severe using validated measures...
May 9, 2018: BJU International
Andrzej Bozek, Jerzy Jarzab, Ewa Hadas, Marek Jakalski, Giorgio Walter Canonica
OBJECTIVE: Evidence of an increased risk of falls in patients with chronic obstructive pulmonary disease (COPD) exists; however, this has not been studied in elderly asthmatic patients. The aim of the study was to determine the incidence of falls in elderly patients who were diagnosed with bronchial asthma compared to subjects with COPD. METHODS: A 12 - month prospective observational study in elderly outpatients with diagnosis of either asthma or COPD was conducted...
May 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Kedir N Turi, Jyoti Shankar, Larry J Anderson, Devi Rajan, Kelsey Gaston, Tebeb Gebretsadik, Suman R Das, Cosby Stone, Emma K Larkin, Christian Rosas-Salazar, Steven M Brunwasser, Martin L Moore, R Stokes Peebles, Tina V Hartert
RATIONALE: Recurrent wheeze and asthma are thought to result from alterations in early life immune development following RSV infection, however, prior studies of the nasal immune-response to infection have assessed only individual cytokines, which doesn't capture the whole spectrum of response to infection. OBJECTIVE: To identify nasal immune phenotypes in response to RSV infection and their association with recurrent wheeze. METHODS: A birth cohort of term healthy infants born June-December were recruited and followed to capture the first infant RSV infection...
May 7, 2018: American Journal of Respiratory and Critical Care Medicine
Victoria S Sukhan
OBJECTIVE: Introduction: The combination of asthma and obesity can affect the mutual encumbrance to which other pathogenetic mechanisms join, which worsen the course of both diseases. The aim of the work is to analyze the features of the genotype and phenotype in patients with a combined course of asthma and obesity. PATIENTS AND METHODS: Materials and methods: In order to detect the features of obesity asthma, 108 patients were examined. Patients were divided into two groups: the first included 50 patients with normal body weight, the second - 58 patients with obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
M Cole, K Bandeen-Roche, A G Hirsch, J R Kuiper, A S Sundaresan, B K Tan, R P Schleimer, R C Kern, B S Schwartz
BACKGROUND: Sinonasal symptoms are common and can have several underlying causes. When symptoms occur in specified patterns lasting 3 months or more they meet criteria for chronic rhinosinusitis (CRS). Approaches to CRS symptom measurement do not specify how to measure symptoms and treat specified sinonasal symptoms as generally interchangeable, suggesting that such symptoms should cluster on 1 or 2 latent factors. METHODS: We used questionnaire responses to 37 questions on the presence, severity, bother, and frequency of cardinal sinonasal and related symptoms lasting 3 months, from 3535 subjects at 3 time points over 16 months...
May 5, 2018: Allergy
Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, Fabio Luigi Massimo Ricciardolo
No abstract text is available yet for this article.
April 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Sabrina Oppenheimer, Orit Krispin, Sigal Levy, Maayan Ozeri, Alan Apter
This study examined the relationship among chronic disease, coping strategy patterns, and health-related quality of life (HRQOL) among children and adolescents. The cohort included 273 Israeli children and adolescents aged 8-18 years diagnosed with asthma, diabetes mellitus, or celiac disease. All completed the Coping with a Disease Questionnaire (CODI) and the DISABKIDS Chronic Generic Measure (DCGM-37). The outcome measures were as follows: association of the use of effective and non-effective coping strategies with type of disease; predictive value of coping patterns for health-related quality of life; a European sample was used for comparison...
June 2018: European Journal of Pediatrics
Ellen E Kersten, Nancy E Adler, Laura Gottlieb, Douglas P Jutte, Sarah Robinson, Katrina Roundfield, Kaja Z LeWinn
: media-1vid110.1542/5751513300001PEDS-VA_2017-2309 Video Abstract OBJECTIVES: Although health care providers and systems are increasingly interested in patients' nonmedical needs as a means to improve health, little is known about neighborhood conditions that contribute to child health problems. We sought to determine if a novel, publicly available measure of neighborhood context, the Child Opportunity Index, was associated with pediatric acute care visit frequency and diagnoses. METHODS: This cross-sectional study included San Francisco residents <18 years of age with an emergency department and/or urgent care visit to any of 3 medical systems ( N = 47 175) between 2007 and 2011...
May 2018: Pediatrics
Jiangtao Lin, Wenya Wang, Ping Chen, Xin Zhou, Huanying Wan, Kaisheng Yin, Lijun Ma, Changgui Wu, Jing Li, Chuntao Liu, Nan Su, Guoliang Liu, Hua Xie, Wei Tang, Mao Huang, Yan Chen, Yuanhua Liu, Liqiang Song, Xianliang Chen, Yongming Zhang, Wen Li, Lichao Sun
BACKGROUND: There are limited population based data on the prevalence of asthma in China. The China Asthma and Risk factors Epidemiologic (CARE) survey was designed to understand the prevalence and risk factors for asthma in mainland China. OBJECTIVES: The CARE survey aims to demonstrate the prevalence and risk factors of asthma in mainland China among adolescents (age >14 years) and adults. METHODS: The survey was performed between February 2010 and August 2012 in eight provinces/cities of seven areas in mainland China...
April 2018: Respiratory Medicine
A Deccache, A Didier, P Mayran, A Jeziorski, C Raherison
INTRODUCTION: This work is based on the data of REALISE™, a survey conducted among 8000 European patients to identify the profiles of adult asthma patients and how these are linked with treatment adherence behaviors. METHODS: A cluster analysis was performed by combining data in three ways: control of asthma, attitude towards the disease, compliance with treatment. A multidisciplinary group analyzed the results for the 1024 French survey respondents. RESULTS: Four patient profiles were identified: "rather confident" (28% of patients), rather young patients with a low level of concern about their asthma...
March 2018: Revue des Maladies Respiratoires
Fulvio Braido, Angelica Tiotiu, Krzysztof Kowal, Stefan Mihaicuta, Plamena Novakova, Ipek Kivilcim Oguzulgen
PURPOSE OF REVIEW: Target therapy is the necessary step towards personalized medicine. The definition of asthma phenotypes and underlying mechanisms (endotypes) represent a key point in the development of new asthma treatments. Big data analysis, biomarker research and the availability of monoclonal antibodies, targeting specific cytokines is leading to the rapid evolution of knowledge. In this review, we sought to outline many of the recent advances in the field. RECENT FINDINGS: Several attempts have been made to identify asthma phenotypes, sometimes with contrasting results...
June 2018: Current Opinion in Allergy and Clinical Immunology
Ming-Wei Su, Wen-Chang Lin, Ching-Hui Tsai, Bor-Luen Chiang, Yao-Hsu Yang, Yu-Tsan Lin, Li-Chieh Wang, Jyh-Hong Lee, Chen-Cheng Chou, Yi-Fan Wu, Yu-Liang Yeh, Yungling L Lee
BACKGROUND: Childhood asthma comprises different phenotypes with complex pathophysiology. Different asthma phenotypes evoke various clinical symptoms and vary in their responses to treatments. METHODS: We applied k-means clustering algorithm of twelve objective laboratory tests among 351 asthmatic children enrolled in the Taiwanese Consortium of Childhood Asthma Study (TCCAS). We constructed gene expression profiles of peripheral blood mononuclear cells (PBMC) from children with different asthma phenotypes...
March 25, 2018: Allergy
Bo Zhuang, Zhi-Ming Bi, Zi-Yuan Wang, Li Duan, Chang-Jiang-Sheng Lai, E-Hu Liu
Platycladi Cacumen (PC) is a traditional Chinese medicine used for the treatment of hemorrhages, cough, asthma and hair loss. To get a better understanding of the chemical constituents in PC, ultra-high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC-Q-TOF-MS/MS) and diagnostic ion filtering strategy were firstly employed for chemical profiling of PC. A total of 43 compounds including organic acids and derivatives, flavonoids as well as phenylpropanolds were unambiguously or reasonably identified...
May 30, 2018: Journal of Pharmaceutical and Biomedical Analysis
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