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https://www.readbyqxmd.com/read/28749421/dsm-5-changes-in-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorder-implications-for-comorbid-sleep-issues
#1
REVIEW
Ujjwal P Ramtekkar
Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) are the most common neurodevelopmental disorders. Despite significant comorbidity, the previous diagnostic criteria prohibited the simultaneous diagnosis of both disorders. Sleep problems are highly prevalent in both disorders; however, these have been studied independently for ADHD and ASD. In the context of revised criteria in the Diagnostic Statistical Manual of Mental Disorders 5th edition (DSM-5) that allows combined diagnosis of ADHD and ASD, this short review presents an overview of relationship between sleep problems, ADHD and ASD, as well as conceptualizing the shared pathophysiology...
July 27, 2017: Children
https://www.readbyqxmd.com/read/28749411/advances-in-testing-techniques-for-digital-microfluidic-biochips
#2
REVIEW
Vineeta Shukla, Fawnizu Azmadi Hussin, Nor Hisham Hamid, Noohul Basheer Zain Ali
With the advancement of digital microfluidics technology, applications such as on-chip DNA analysis, point of care diagnosis and automated drug discovery are common nowadays. The use of Digital Microfluidics Biochips (DMFBs) in disease assessment and recognition of target molecules had become popular during the past few years. The reliability of these DMFBs is crucial when they are used in various medical applications. Errors found in these biochips are mainly due to the defects developed during droplet manipulation, chip degradation and inaccuracies in the bio-assay experiments...
July 27, 2017: Sensors
https://www.readbyqxmd.com/read/28749243/epidemiology-and-trend-of-pediatric-adenoidectomy-a-population-based-study-in-taiwan-from-1997-to-2012
#3
Chia-Hsuan Lee, Wei-Chung Hsu, Jenq-Yuh Ko, Te-Huei Yeh, Wei-Hsiu Chang, Kun-Tai Kang
OBJECTIVES: To assess population-level data for pediatric adenoidectomy. METHODS: Using data from the Taiwan National Health Insurance Research Database for the 1997-2012 period, all inpatients <18 years who received adenoidectomies were identified by codes from the International Classification of Diseases, 9th Revision. RESULTS: A total of 20,599 children underwent adenoidectomy (mean age, 7.4 years; 67% boys). The overall incidence rate was 24...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28749204/revision-of-a-furosemide-loading-vestibular-evoked-myogenic-potential-protocol-for-detecting-endolymphatic-hydrops
#4
Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Katsumi Doi
OBJECTIVE: The presence of endolymphatic hydrops can be suggested by improving the amplitude of vestibular-evoked myogenic potential (VEMP) after furosemide administration (furosemide loading VEMP [FVEMP]). The authors aimed to determine a stimulation frequency and judgment criteria to ascertain whether a revised FVEMP protocol can be applied to clinical settings. METHODS: The study included 25 individuals with unilateral Meniere's disease (MD) and 11 normal healthy volunteers...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28748847/clinical-features-of-isolated-bulbar-palsy-of-amyotrophic-lateral-sclerosis-in-chinese-population
#5
Hua-Gang Zhang, Lu Chen, Lu Tang, Nan Zhang, Dong-Sheng Fan
BACKGROUND: Progressive bulbar palsy (PBP) is a classic phenotype of bulbar onset amyotrophic lateral sclerosis (ALS) with more rapid progression and worse prognosis. However, as an often under-understood variant of ALS, isolated bulbar palsy (IBP) appears to progress more slowly and has a relatively benign prognosis. This study aimed to investigate the natural course and clinical features of IBP in Chinese population and to compare them with those of PBP. METHODS: The clinical data of patients with bulbar onset ALS were collected from January 2009 to December 2013...
August 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28748721/real-world-costs-and-outcomes-in-metastatic-renal-cell-carcinoma-patients-treated-by-targeted-therapies-a-cohort-study-from-the-french-health-insurance-database
#6
Rana Maroun, Laetitia Fleury, Gaelle Nachbaur, Franck Maunoury, Jean-Louis Vanhille, Isabelle Durand-Zaleski
OBJECTIVES: The objective of this study was to describe treatment patterns, survival, healthcare use and costs in patients with metastatic renal cell carcinoma (mRCC) in a real-world setting. RESEARCH DESIGN AND METHODS: We used the National Health Insurance (NHI) claims database for the Ile-de-France region to perform a retrospective cohort analysis of patients with mRCC treated by a first-line targeted therapy. Treatment naïve patients were identified combining the 10(th) revision of the International Classification of Diseases (ICD-10) codes (C64 & C77-C79) and a first prescription of targeted therapies...
July 27, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28748519/obstetric-antiphospholipid-syndrome-and-long-term-arterial-thrombosis-risk
#7
Genady Drozidnsky, Eran Hadar, Anat Shmueli, Rinat Gabbay-Benziv, Shachaf Shiber
Antiphospholipid syndrome (APS) is classified as the association of a thrombotic event and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies and/or lupus anticoagulant. To evaluate the incidence of subsequent thrombosis among women diagnosed with purely obstetric APS. We retrospectively reviewed and collected demographic and clinical data from the computerized charts of all patients with obstetric APS, from 1992 to 2017. Eligibility criteria included all women diagnosed with APS, according to the 2006 revised criteria, for whom the clinical manifestations were purely obstetric...
July 26, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28748515/tumor-necrosis-factor-%C3%AE-308-polymorphism-in-north-indian-rheumatoid-arthritis-patients-and-association-with-mrna-and-serum-tnf-%C3%AE
#8
Mohd Jahid, Rehan-Ul-Haq, Puja Kumari Jha, Diwesh Chawla, Rajnish Avasthi, Rafat Sultana Ahmed
Rheumatoid arthritis (RA) is a severely disabling chronic autoimmune disorder that leads to progressive inflammation of the joints and surrounding tissues. TNF-α, a potent proinflammatory cytokine, plays a pivotal role in the pathogenesis of RA. The endogenous formation of TNF-α may be influenced by TNF-α promoter polymorphisms. Hence, the present study was designed to explore any possible association between genetic polymorphism of TNF-α -308 G/A, messenger RNA (mRNA) expression, serum levels of TNF-α, and inflammatory markers in North Indian RA patients...
July 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748509/clinical-characteristics-and-thrombosis-outcomes-of-paediatric-antiphospholipid-syndrome-analysis-of-58-patients
#9
Jingran Ma, Hongmei Song, Min Wei, Yanyan He
The study aims to analyse the clinical and immunological manifestations of paediatric antiphospholipid syndrome (APS) in patients, based on the 2006 revised classification criteria of definite APS. Fifty-eight paediatric patients with APS were enrolled and analysed retrospectively. A total of 37 female and 21 male patients with a mean age of 14 ± 3 years at disease onset were included. Fourteen (24%) cases were primary APS, and 40 (69%) cases were secondary to systemic lupus erythaematosus (SLE). Anti-nuclear antibody (ANA) positivity and hypocomplementemia were more common in secondary APS than in primary APS...
July 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28748362/case-study-failure-of-superior-capsular-reconstruction-using-dermal-allograft
#10
J Zerr, J D McDermott, N M Beckmann, R K Fullick, A Chhabra
Superior capsular reconstruction (SCR) is a novel technique for treating irreparable rotator cuff tears in younger patients in whom a reverse total shoulder arthroplasty is not the optimal treatment choice. This case study describes a middle-aged male with a recurrent, massive, irreparable rotator cuff tear treated with SCR that subsequently failed at the glenoid attachment. The patient underwent successful arthroscopic revision of the SCR. The case illustrates the MRI and arthroscopic correlations of the failed dermal allograft reconstruction, which to our knowledge has not been previously shown in the radiology literature...
July 26, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28748292/systematic-ct-evaluation-of-reduction-and-hardware-positioning-of-surgically-treated-calcaneal-fractures-a-reliability-analysis
#11
R J O de Muinck Keizer, M S H Beerekamp, D T Ubbink, L F M Beenen, T Schepers, J C Goslings
INTRODUCTION: Up to date, there is a lack of reliable protocols that systematically evaluate the quality of reduction and hardware positioning of surgically treated calcaneal fractures. Based on international consensus, we previously introduced a 23-item scoring protocol evaluating the reduction and hardware positioning in these fractures based on postoperative computed tomography. The current study is a reliability analysis of the described scoring protocol. METHODS: Three raters independently and systematically evaluated anonymized postoperative CT scans of 102 surgically treated calcaneal fractures...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28748291/predictors-of-outcomes-after-arthroscopic-transosseous-equivalent-rotator-cuff-repair-in-155-cases-a-propensity-score-weighted-analysis-of-knotted-and-knotless-self-reinforcing-repair-techniques-at-a-minimum-of-2%C3%A2-years
#12
Peter J Millett, Chris Espinoza, Marilee P Horan, Charles P Ho, Ryan J Warth, Grant J Dornan, J Christoph Katthagen
PURPOSE: To evaluate the outcomes of two commonly used transosseous-equivalent (TOE) arthroscopic rotator cuff repair (RCR) techniques for full-thickness supraspinatus tendon tears (FTST) using a robust multi-predictor model. METHODS: 155 shoulders in 151 patients (109 men, 42 women; mean age 59 ± 10 years) who underwent arthroscopic RCR of FTST, using either a knotted suture bridging (KSB) or a knotless tape bridging (KTB) TOE technique were included. ASES and SF-12 PCS scores assessed at a minimum of 2 years postoperatively were modeled using propensity score weighting in a multiple linear regression model...
July 26, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28748268/-sexual-dysfunction-changing-conceptions-and-criteria-of-classification
#13
REVIEW
Jürgen Hoyer, Julia Velten
BACKGROUND: Sexual response is the result of a complex interaction of psychological, physiological, interpersonal, social and cultural factors. Those factors - as well as sexual behavior - are subject to permanent change. OBJECTIVES: In this study, we investigated how the growth of basic knowledge and constantly changing social-cultural conditions impact the scientific definition of sexual dysfunctions, which controversies exist and to what degree these changes counteract the common tendencies of medicalization and stigmatization of sexual difficulties...
July 26, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28747955/summary-of-the-chronic-obstructive-pulmonary-disease-clinical-practice-guideline-revised-in-2014-by-the-korean-academy-of-tuberculosis-and-respiratory-disease
#14
REVIEW
Hyoung Kyu Yoon, Yong-Bum Park, Chin Kook Rhee, Jin Hwa Lee, Yeon-Mok Oh
Chronic obstructive pulmonary disease (COPD) results in high morbidity and mortality among patients both domestically and globally. The Korean clinical practice guideline for COPD was revised in 2014. It was drafted by the members of the Korean Academy of Tuberculosis and Respiratory Diseases, as well as participating members of the Health Insurance Review and Assessment Service, Korean Physicians' Association, and Korea Respiration Trouble Association. This revised guideline covers a wide range of topics, including the epidemiology, diagnosis, assessment, monitoring, management, exacerbation, and comorbidities of COPD in Korea...
July 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28747902/in-silico-taxonomic-classification-of-373-genomes-reveals-species-misidentification-and-new-genospecies-within-the-genus-pseudomonas
#15
Phuong N Tran, Michael A Savka, Han Ming Gan
The genus Pseudomonas has one of the largest diversity of species within the Bacteria kingdom. To date, its taxonomy is still being revised and updated. Due to the non-standardized procedure and ambiguous thresholds at species level, largely based on 16S rRNA gene or conventional biochemical assay, species identification of publicly available Pseudomonas genomes remains questionable. In this study, we performed a large-scale analysis of all Pseudomonas genomes with species designation (excluding the well-defined P...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28747876/structural-correlates-of-reading-the-mind-in-the-eyes-in-autism-spectrum-disorder
#16
Wataru Sato, Shota Uono, Takanori Kochiyama, Sayaka Yoshimura, Reiko Sawada, Yasutaka Kubota, Morimitsu Sakihama, Motomi Toichi
Behavioral studies have shown that individuals with autism spectrum disorder (ASD) have impaired ability to read the mind in the eyes. Although this impairment is central to their social malfunctioning, its structural neural correlates remain unclear. To investigate this issue, we assessed Reading the Mind in the Eyes Test, revised version (Eyes Test) and acquired structural magnetic resonance images in adults with high-functioning ASD (n = 19) and age-, sex- and intelligence quotient-matched typically developing (TD) controls (n = 19)...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28747301/pharmaceutical-companies-policies-on-access-to-trial-data-results-and-methods-audit-study
#17
Ben Goldacre, Síle Lane, Kamal R Mahtani, Carl Heneghan, Igho Onakpoya, Ian Bushfield, Liam Smeeth
Objectives To identify the policies of major pharmaceutical companies on transparency of trials, to extract structured data detailing each companies' commitments, and to assess concordance with ethical and professional guidance.Design Structured audit.Setting Pharmaceutical companies, worldwide.Participants 42 pharmaceutical companies.Main outcome measures Companies' commitments on sharing summary results, clinical study reports (CSRs), individual patient data (IPD), and trial registration, for prospective and retrospective trials...
July 26, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28747296/tamper-resistant-mobile-health-using-blockchain-technology
#18
Daisuke Ichikawa, Makiko Kashiyama, Taro Ueno
BACKGROUND: Digital health technologies, including telemedicine, mobile health (mHealth), and remote monitoring, are playing a greater role in medical practice. Safe and accurate management of medical information leads to the advancement of digital health, which in turn results in a number of beneficial effects. Furthermore, mHealth can help lower costs by facilitating the delivery of care and connecting people to their health care providers. Mobile apps help empower patients and health care providers to proactively address medical conditions through near real-time monitoring and treatment, regardless of the location of the patient or the health care provider...
July 26, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28747188/transmission-dynamics-of-cholera-in-yemen-2017-a-real-time-forecasting
#19
Hiroshi Nishiura, Shinya Tsuzuki, Baoyin Yuan, Takayuki Yamaguchi, Yusuke Asai
BACKGROUND: A large epidemic of cholera, caused by Vibrio cholerae, serotype Ogawa, has been ongoing in Yemen, 2017. To improve the situation awareness, the present study aimed to forecast the cholera epidemic, explicitly addressing the reporting delay and ascertainment bias. METHODS: Using weekly incidence of suspected cases, updated as a revised epidemic curve every week, the reporting delay was explicitly incorporated into the estimation model. Using the weekly case fatality risk as calculated by the World Health Organization, ascertainment bias was adjusted, enabling us to parameterize the family of logistic curves (i...
July 26, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/28746819/humanized-mouse-models-for-human-immunodeficiency-virus-infection
#20
Matthew D Marsden, Jerome A Zack
Human immunodeficiency virus (HIV) remains a significant source of morbidity and mortality worldwide. No effective vaccine is available to prevent HIV transmission, and although antiretroviral therapy can prevent disease progression, it does not cure HIV infection. Substantial effort is therefore currently directed toward basic research on HIV pathogenesis and persistence and developing methods to stop the spread of the HIV epidemic and cure those individuals already infected with HIV. Humanized mice are versatile tools for the study ofHIVand its interaction with the human immune system...
July 26, 2017: Annual Review of Virology
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