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https://www.readbyqxmd.com/read/28527995/effect-of-aconitum-coreanum-polysaccharide-and-its-sulphated-derivative-on-the-migration-of-human-breast-cancer-mda-mb-435s-cell
#1
Yandong Zhang, Wei Wu, Lihua Kang, Dehai Yu, Chunshui Liu
Polysaccharides extracted from medicinal plants possess multiple functions. However, the inhibitory capacity of polysaccharides on the metastasis of breast cancer remains unclear. In the present study, we investigated the inhibitory activity of Aconitum coreanum polysaccharide (ACP1) and its sulphated derivative ACP1-s on migratory behaviour of human breast cancer cells MDA-MB-435s and evaluated the underlying molecular mechanism. The data from Transwell assay indicated that ACP1 and ACP1-s caused a significant inhibition of MDA-MB-435s cell migration in vitro...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28517991/self-knowledge-and-risk-in-stratified-medicine
#2
Joshua Hordern
This article considers why and how self-knowledge is important to communication about risk and behaviour change by arguing for four claims. First, it is doubtful that genetic knowledge should properly be called 'self-knowledge' when its ordinary effects on self-motivation and behaviour change seem so slight. Second, temptations towards a reductionist, fatalist, construal of persons' futures through a 'molecular optic' should be resisted. Third, any plausible effort to change people's behaviour must engage with cultural self-knowledge, values and beliefs, catalysed by the communication of genetic risk...
April 2017: New Bioethics: a Multidisciplinary Journal of Biotechnology and the Body
https://www.readbyqxmd.com/read/28514992/sexual-difficulties-faced-by-men-in-the-solomon-islands-a-mixed-methods-study
#3
Paraniala Silas C Lui, Michael P Dunne, Philip Baker, Verzilyn Isom
Background: To date there has been little research into men's sexual and reproductive health in Pacific Island countries. The aim of this study was to describe men's sexual difficulties and barriers to their seeking reproductive health care in the Solomon Islands. Methods: The study included qualitative inquiry (17 individual interviews and three focus group discussions with a total of 21 men) and a quantitative quasi-randomised quota sample household survey (n=400). The prevalence of sexual difficulties and potential risk factors, such as chronic diseases, health risk behaviours, depression and psychological distress were measured using standardised questions translated into pidgin...
May 18, 2017: Sexual Health
https://www.readbyqxmd.com/read/28514888/seeing-is-believing-healthcare-professionals-perceptions-of-a-complex-intervention-to-improve-care-towards-the-end-of-life-a-qualitative-interview-study
#4
Katherine Bristowe, Irene Carey, Adrian Hopper, Susanna Shouls, Wendy Prentice, Irene J Higginson, Jonathan Koffman
BACKGROUND: Methods to improve care, trust and communication are important in acute hospitals. Complex interventions aimed at improving care of patients approaching the end of life are increasingly common. While evaluating outcomes of complex interventions is essential, exploring healthcare professionals' perceptions is also required to understand how they are interpreted; this can inform training, education and implementation strategies to ensure fidelity and consistency in use. AIM: To explore healthcare professionals' perceptions of using a complex intervention (AMBER care bundle) to improve care for people approaching the end of life and their understandings of its purpose within clinical practice...
May 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/28510736/go-no-go-decision-in-anaesthesia-wide-variation-in-risk-tolerance-amongst-anaesthetists
#5
P R Greig, H E Higham, J L Darbyshire, C Vincent
Background: The variability in risk tolerance in medicine is not well understood. Parallels are often drawn between aviation and anaesthesia. The aviation industry is perceived as culturally risk averse, and part of preflight checks involves a decision on whether the flight can operate. This is sometimes termed a go/no-go decision. This questionnaire study was undertaken to explore the equivalent go/no-go decision in anaesthesia. We presented anaesthetists with a range of situations in which additional risk might be expected and asked them to decide whether they would proceed with the case...
May 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28510600/complete-comparison-display-ccd-evaluation-of-ethanol-extracts-of-centella-asiatica-and-withania-somnifera-shows-that-they-can-non-synergistically-ameliorate-biochemical-and-behavioural-damages-in-mptp-induced-parkinson-s-model-of-mice
#6
Maheep Bhatnagar, Ishan Goel, Tathagato Roy, Sunil Dutt Shukla, Sukant Khurana
Parkinson's disease remains as one of the most common debilitating neurodegenerative disorders. With the hopes of finding agents that can cure or reduce the pace of progression of the disease, we studied two traditional medicinal plants: Centella asiatica and Withania somnifera that have been explored in some recent studies. In agreement with the previous work on ethanol extracts of these two plants in mice model, we saw an improvement in oxidative stress profile as well as behavioral performance in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced Parkinson-like symptoms in Balb/c mice...
2017: PloS One
https://www.readbyqxmd.com/read/28507772/clinically-significant-depressive-symptoms-and-sexual-behaviour-among-men-who-have-sex-with-men
#7
Ada R Miltz, Alison J Rodger, Janey Sewell, Andrew Speakman, Andrew N Phillips, Lorraine Sherr, Richard J Gilson, David Asboe, Nneka C Nwokolo, Amanda Clarke, Mark M Gompels, Sris Allan, Simon Collins, Fiona C Lampe
BACKGROUND: The relationship between depression and sexual behaviour among men who have sex with men (MSM) is poorly understood. AIMS: To investigate prevalence and correlates of depressive symptoms (Patient Health Questionnaire-9 score ≥10) and the relationship between depressive symptoms and sexual behaviour among MSM reporting recent sex. METHOD: The Attitudes to and Understanding of Risk of Acquisition of HIV (AURAH) is a cross-sectional study of UK genitourinary medicine clinic attendees without diagnosed HIV (2013-2014)...
May 2017: BJPsych Open
https://www.readbyqxmd.com/read/28507229/spread-of-competing-viruses-on-heterogeneous-networks
#8
Shanshan Chen, Kaihua Wang, Mengfeng Sun, Xinchu Fu
In this paper, we propose a model where two strains compete with each other at the expense of common susceptible individuals on heterogeneous networks by using pair-wise approximation closed by the probability-generating function (PGF). All of the strains obey the susceptible-infected-recovered (SIR) mechanism. From a special perspective, we first study the dynamical behaviour of an SIR model closed by the PGF, and obtain the basic reproduction number via two methods. Then we build a model to study the spreading dynamics of competing viruses and discuss the conditions for the local stability of equilibria, which is different from the condition obtained by using the heterogeneous mean-field approach...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28507228/understanding-principles-of-integration-and-segregation-using-whole-brain-computational-connectomics-implications-for-neuropsychiatric-disorders
#9
REVIEW
Louis-David Lord, Angus B Stevner, Gustavo Deco, Morten L Kringelbach
To survive in an ever-changing environment, the brain must seamlessly integrate a rich stream of incoming information into coherent internal representations that can then be used to efficiently plan for action. The brain must, however, balance its ability to integrate information from various sources with a complementary capacity to segregate information into modules which perform specialized computations in local circuits. Importantly, evidence suggests that imbalances in the brain's ability to bind together and/or segregate information over both space and time is a common feature of several neuropsychiatric disorders...
June 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28487461/the-impact-of-duty-cycle-workflow-on-sign-out-practices-a-qualitative-study-of-an-internal-medicine-residency-program-in-maryland-usa
#10
Soo-Hoon Lee, Sanjay V Desai, Phillip H Phan
OBJECTIVES: Although JCAHO requires a standardised approach to handoffs, and while many standardised protocols have been tested, sign-out practices continue to vary. We believe this is due to the variability in workflow during inpatient duty cycle. We investigate the impact of such workflows on intern sign-out practices. DESIGN: We employed a prospective, grounded theory mixed-method design. SETTING: The study was conducted at a residency programme in the mid-Atlantic USA...
May 9, 2017: BMJ Open
https://www.readbyqxmd.com/read/28483923/rethinking-priorities-experience-of-an-educational-initiative-to-change-attitudes-behaviours-and-clinical-practice-in-end-of-life-care
#11
Annette Edwards, Viv Barros D'Sa, Fiona Hicks
To implement the National End of Life Care strategy and enable more people to express and achieve their preferences about care at the end of life, senior clinicians outside palliative medicine need to make it a routine part of their practice. However, it is acknowledged that recognising that people are entering the last phase of their illness is not always straightforward, and having conversations about aims of treatment and planning for future care may not be easy. In order to begin to address these challenges, funding was sought from the Yorkshire and the Humber Strategic Health Authority (SHA), and subsequently Health Education England, Yorkshire and the Humber (HEEYH), to pilot a development programme in 2 acute trusts...
May 8, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28483694/controlling-nucleation-and-growth-of-nano-caco3-via-co2-sequestration-by-a-calcium-alkoxide-solution-to-produce-nanocomposites-for-drug-delivery-applications
#12
N G Martin Palmqvist, Jean-Marie Nedelec, Gulaim A Seisenbaeva, Vadim G Kessler
Calcium carbonate is an extremely attractive material in a plethora of biomedical applications. Intensive efforts have recently been made to achieve the control over its nucleation and subsequent aggregation, growth and crystallization; focusing on bringing insight into the role of precursors, solvents and templates. Having analyzed the recently acquired knowledge, we addressed this challenge using CO2 sequestration synthesis, using an unusual reactant, a solution of calcium ethoxide, Ca(OC2H5)2, as precursor...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28483174/-impact-of-a-multimodal-intervention-on-the-psychological-profile-of-schizophrenic-and-bipolar-i-patients-a-study-of-prisma-program
#13
Ana María Díaz-Zuluaga, Cristian Vargas, Kelly Duica, Shanel Richard, Juan David Palacio, Yuli Agudelo Berruecos, Sigifredo Ospina, Carlos López-Jaramillo
BACKGROUND: Bipolar Disorder (BD) and schizophrenia are included in the group of severe mental illness and are main causes of disability and morbidity in the local population due to the bio-psycho-social implications in patients. In the last 20 years or so, adjunctive psychological interventions been studied with the purpose of decreasing recurrences, stabilising the course of the disease, and improving the functionality in these patients. OBJECTIVE: To analyse the psychological effect of a multimodal intervention (MI) vs a traditional intervention (TI) program in BD I and schizophrenic patients...
April 2017: Revista Colombiana de Psiquiatría
https://www.readbyqxmd.com/read/28482527/rubber-elastomeric-nanocomposites-with-antimicrobial-properties
#14
Małgorzata Przybyłek, Mohamed Bakar, Mariola Mendrycka, Urszula Kosikowska, Anna Malm, Marta Worzakowska, Tomasz Szymborski, Karolina Kędra-Królik
In this paper we show an elastomeric nanocomposite that exhibits antibacterial and antifungal activity. It comprises a rubber blend matrix and a nanofiller, which is a modified bentonite clay (Nanobent® ZR2). We have developed innovative technology for the nanofiller incorporation into the rubber matrix. This new approach was successfully implemented in pilot production at the Polish chemical manufacturer Spoiwo (Spoldzielnia Pracy Chemiczno-Wytworczej 'Spoiwo', Radom, Poland). Here we reveal that addition of the functionalised bentonite affects the mechanical and thermal behaviour of elastomers...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482238/nocturnal-sleep-architecture-is-altered-by-sleep-bruxism
#15
Marcelo Palinkas, Marisa Semprini, João Espir Filho, Graziela de Luca Canto, Isabela Hallak Regalo, César Bataglion, Laíse Angélica Mendes Rodrigues, Selma Siéssere, Simone Cecilio Hallak Regalo
OBJECTIVE: Sleep is a complex behaviour phenomenon essential for physical and mental health and for the body to restore itself. It can be affected by structural alterations caused by sleep bruxism. The aim of this study was to verify the effects of sleep bruxism on the sleep architecture parameters proposed by the American Academy of Sleep Medicine. DESIGN: The sample comprised 90 individuals, between the ages of 18 and 45 years, divided into two groups: with sleep bruxism (n=45) and without sleep bruxism (n=45)...
April 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28480429/ethnobotanical-survey-of-phoenix-dactylifera-l-pollen-used-for-the-treatment-of-infertility-problems-in-algerian-oases
#16
Cherifa Selmani, Djamila Chabane, Nadia Bouguedoura
BACKGROUND: The Phoenix dactylifera L. (date palm) is known for its traditional medicinal properties across the history of native population in Algerian Sahara. There is a large trend of consumption of date palm pollen preparations in many human infertility cases in our country. However, the validity has not been scientifically tested. There has been no direct scientific research on this application. This study was undertaken to identify cultivars with greater potential in the traditional medicine uses...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28475365/the-differences-between-medical-trust-and-mistrust-and-their-respective-influences-on-medication-beliefs-and-art-adherence-among-african-americans-living-with-hiv
#17
Jennifer A Pellowski, Devon M Price, Aerielle M Allen, Lisa A Eaton, Seth C Kalichman
OBJECTIVE: The purpose of this study was to examine the relationships between medical mistrust and trust and to determine if these measures differentially predict antiretroviral therapy (ART) medication adherence for African-American adults living with HIV. DESIGN: A total of 458 HIV positive African-Americans completed a cross-sectional survey. MAIN OUTCOME MEASURES: Self-reported ART adherence was collected using the visual-analog scale...
May 5, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28474056/challenges-of-integrating-evidence-into-health-policy-and-planning-linking-multiple-disciplinary-approaches
#18
Carmen Huckel Schneider, Fiona Blyth
OBJECTIVES: To explore the challenges that arise through the multidisciplinary nature of evidence informed policy making (EIPM). Type of program or service: Education and practice for EIPM. METHODS: This article summarises and compares four disciplinary approaches to EIPM with highly contrasting starting points: behavioural science, policy science, critical theory and intervention research. Key insights and theories are highlighted to provide a gateway into each, and to complement what is already known about the evidence needs of policy makers in terms of high-quality, timely and well-communicated research evidence...
April 27, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/28473208/-working-conditions-in-outpatient-clinics-adjacent-to-private-pharmacies-in-mexico-city-perspective-of-physicians
#19
Sandra P Díaz-Portillo, Hortensia Reyes-Morales, Silvia Magali Cuadra-Hernández, Álvaro J Idrovo, Gustavo Nigenda, Anahí Dreser
OBJECTIVE: To analyse the working conditions of physicians in outpatient clinics adjacent to pharmacies (CAFs) and their organizational elements from their own perspective. METHODS: We carried out an exploratory qualitative study. Semi-structured interviews were conducted with 32 CAF physicians in Mexico City. A directed content analysis technique was used based on previously built and emerging codes which were related to the experience of the subjects in their work...
May 1, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28472808/idiopathic-pulmonary-fibrosis-molecular-endotypes-of-fibrosis-stratifying-existing-and-emerging-therapies
#20
Daniele Magnini, Giuliano Montemurro, Bruno Iovene, Linda Tagliaboschi, Rafael Emanuele Gerardi, Erminia Lo Greco, Teresa Bruni, Alessio Fabbrizzi, Francesco Lombardi, Luca Richeldi
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown causes. Current diagnostic criteria are based on radiological, clinical, and histopathological features but, unfortunately, still many patients remain undiagnosed. Two currently approved therapies, pirfenidone and nintedanib, slow down disease progression but failed to block or revert it. On the other hand, many of the therapeutic agents tested in several clinical trials have not given satisfactory answers, probably due to the pathological heterogeneity of the disease...
May 5, 2017: Respiration; International Review of Thoracic Diseases
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