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https://www.readbyqxmd.com/read/29926257/deprescribing-admission-medication-at-a-uk-teaching-hospital-a-report-on-quantity-and-nature-of-activity
#1
Sion Scott, Allan Clark, Carol Farrow, Helen May, Martyn Patel, Michael James Twigg, David John Wright, Debi Bhattacharya
Background Deprescribing medication may be in response to an adverse clinical trigger (reactive) or if future gains are unlikely to outweigh future harms (proactive). A hospital admission may present an opportunity for deprescribing, however current practice is poorly understood. Objective To quantify and describe the nature of deprescribing in a UK teaching hospital. Method Prescribing and discontinuation data for admission medication from a hospital's electronic prescribing system were extracted over 4 weeks...
June 20, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29920356/clitoria-ternatea-l-rootextract-ameliorated-the-cognitive-and-hippocampal-long-term-potentiation-deficits-induced-by-chronic-cerebral-hypoperfusion-in-the-rat
#2
Thenmoly Damodaran, Byorn Wei Liang Tan, Ping Liao, Surash Ramanathan, Lim Gin Keat, Zurina Hassan
ETHNOPHARMACOLOGICAL RELEVANCE: Clitoria ternatea L. (CT), commonly known as Butterfly pea, is used in Indian Ayurvedic medicine to promote brain function and treat mental disorders. Root of CT has been proven to enhance memory, but its role in an animal model of chronic cerebral hypoperfusion (CCH), which has been considered as a major cause of brain disorders, has yet to be explored. AIM OF THE STUDY: To assess the motor and cognitive effects of acute oral administration of CT root methanolic extract and hippocampal long-term plasticity in the CA1 region of the CCH rat model...
June 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29915979/trials-with-patient-reported-outcomes-registered-on-the-australian-new-zealand-clinical-trials-registry-anzctr
#3
Rebecca Mercieca-Bebber, Douglas Williams, Margaret-Ann Tait, Jessica Roydhouse, Lucy Busija, Chindhu Shunmuga Sundaram, Michelle Wilson, Ailsa Langford, Claudia Rutherford, Natasha Roberts, Madeleine King, Elisabeth Vodicka, Beth Devine
AIMS: It is important to understand the number, types and regions of trials that include patient-reported outcomes (PROs) to appreciate how patient experiences have been considered in studies of health and interventions. Twenty-seven percent of trials registered with ClinicalTrials.gov (2007-2013) included PROs; however, a regional breakdown was not provided and no reviews have been conducted of the Australia New Zealand Clinical Trials Registry (ANZCTR). We aimed to identify trials registered with ANZCTR with PRO endpoints and describe their characteristics...
June 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29913682/gch1-variants-tetrahydrobiopterin-and-their-effects-on-pain-sensitivity
#4
REVIEW
Arafat Nasser, Lisbeth Birk Møller
Background A great proportion of the variation in pain experience and chronicity is caused by heritable factors. Within the last decades several candidate genes have been discovered either increasing or decreasing pain sensitivity or the risk of chronic pain in humans. One of the most studied genes is the GCH1 gene coding for the enzyme GTP cyclohydrolase 1 (GCH1). GCH1 catalyses the initial and rate-limiting step in the biosynthesis of tetrahydrobiopterin (BH4). The main function of BH4 is regulation of monoamine and nitric oxide biosynthesis, all involved in nociceptive signalling...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29908352/man1b-cdg-novel-variants-with-a-distinct-phenotype-and-review-of-literature
#5
Meena Balasubramanian, Diana S Johnson
BACKGROUND: Congenital disorders of glycosylation (CDG) are a group of rare metabolic diseases due to impaired lipid and protein glycosylation. It comprises a characteristic high frequency of intellectual disability (ID) and a wide range of clinical phenotypes. OBJECTIVE: (s): To identify the underlying diagnosis in two families each with two siblings with variable level of ID through trio whole exome sequencing. METHODS: Both the families were recruited to the Deciphering Developmental Disorders (DDD) study to identify the aetiology for their ID...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908314/quality-control-of-goji-fruits-of-lycium-barbarum-l-and-l-chinense-mill-a-value-chain-analysis-perspective
#6
Ruyu Yao, Michael Heinrich, Zigui Wang, Caroline S Weckerle
ETHNOPHARMACOLOGICAL RELEVANCE: Goji (fruits of Lycium barbarum L. and L. chinense Mill., Solanaceae) have been used as a traditional food and medicine for hundreds of years in Asian countries and are now consumed globally. Quality of herbal medicines is critical for safe use and has been shown to be affected by value chains. AIM OF THE STUDY: Using a value chain (VC) framework, we aim at understanding the influence of different VC types on goji quality and revenue of stakeholders...
June 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29904585/recent-advances-in-deep-brain-stimulation-in-psychiatric-disorders
#7
REVIEW
Anne-Hélène Clair, William Haynes, Luc Mallet
Deep brain stimulation (DBS) has been offered to patients suffering of severe and resistant neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD), Gilles de la Tourette Syndrome (TS) and Major Depression (MDD). Modulation of several targets within the cortico-striato-thalamo-cortical circuits can lead to a decrease of symptom severity in those patients. This review focuses on the recent clinical outcomes in DBS in psychiatric disorders. Studies on OCD and TS are now focusing on the long-term effects of DBS, with encouraging results regarding not only the decrease of symptoms, but also quality of life...
2018: F1000Research
https://www.readbyqxmd.com/read/29899014/a-surrogate-s-secrets-are-n-t-safe-with-me-patient-confidentiality-in-the-care-of-a-gestational-surrogate
#8
Claire Horner, Paul Burcher
Gestational surrogacy relies on a legal agreement between the surrogate and the intended parents to define the roles and responsibilities of the parties, including explicit consent by the surrogate to allow the physician to release all pregnancy-related medical information to the intended parents. In the event of surrogate misconduct, however, physicians may feel conflicted if the surrogate asks the physician to withhold information about potentially dangerous behaviour in pregnancy from the intended parents...
June 13, 2018: Journal of Medical Ethics
https://www.readbyqxmd.com/read/29898741/reversal-of-reserpine-induced-depression-and-cognitive-disorder-in-zebrafish-by-sertraline-and-traditional-chinese-medicine-tcm
#9
Shuhui Zhang, Xiaodong Liu, Mingzhu Sun, Qiuping Zhang, Teng Li, Xiang Li, Jia Xu, Xin Zhao, Dongyan Chen, Xizeng Feng
BACKGROUND: With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour. METHODS: The constituents of JWXY capsule were identified by ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry analyses...
June 14, 2018: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/29895825/an-immortalised-mesenchymal-stem-cell-line-maintains-mechano-responsive-behaviour-and-can-be-used-as-a-reporter-of-substrate-stiffness
#10
Asier Galarza Torre, Joshua E Shaw, Amber Wood, Hamish T J Gilbert, Oana Dobre, Paul Genever, Keith Brennan, Stephen M Richardson, Joe Swift
The mechanical environment can influence cell behaviour, including changes to transcriptional and proteomic regulation, morphology and, in the case of stem cells, commitment to lineage. However, current tools for characterizing substrates' mechanical properties, such as atomic force microscopy (AFM), often do not fully recapitulate the length and time scales over which cells 'feel' substrates. Here, we show that an immortalised, clonal line of human mesenchymal stem cells (MSCs) maintains the responsiveness to substrate mechanics observed in primary cells, and can be used as a reporter of stiffness...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29889457/-pharmacological-and-nonpharmacological-treatment-of-insomnias-with-regard-to-sleep-medicine
#11
REVIEW
Béla Faludi, Renáta Rozgonyi
Insomnia - one of the most prevalent sleep complain - has a great impact on the everyday life. Basically two different form of insomnia can be defined: the insomnia disorder and the co-morbid insomnias. To treat adequately determination of background pathology is essential, which is based on the help of Sleep Medicine Centers. According to the newest guidelines, the treatment of insomnia disorder is based on cognitive behavioural therapies followed by pharmaceutical intervention. In this review we provide the short description of cognitive behavioural therapies and basic principles of hypnotic drugs...
May 30, 2018: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29889092/leisure-time-physical-activity-as-a-compensation-for-sedentary-behaviour-of-professionally-active-population
#12
Elżbieta Biernat, Monika Piątkowska
BACKGROUND: The aim of this work is to estimate leisure-time physical activity (LTPA) of the professionally-active population as a factor in early preventive medicine and diagnosing threats of occupational diseases. It was the basis for an analysis of the realisation of a pro-health dose of physical activity recommended by WHO (depending on the profession). OBJECTIVE AND METHODS: A survey based on IPAQ-LV was realised in 2014-2015 on a representative sample of Poles (n = 2039)...
June 5, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29884533/copd-patient-education-and-support-achieving-patient-centredness
#13
Ana Stoilkova-Hartmann, Frits M E Franssen, Ingrid M L Augustin, Emiel F M Wouters, Katharine D Barnard
BACKGROUND: The art of medicine is undergoing a dramatic shift in focus, evolving to focus on patient involvement as partners in care, transforming the traditional, prescriptive, reactive practice of healthcare into a proactive discipline. The personal and societal burden of chronic diseases is burgeoning and unsustainable in current systems, novel approaches are required to address this. DISCUSSION: Although considerable progress has been made in the development of diagnostics, therapeutics and care guidelines for patients with chronic obstructive pulmonary disease (COPD), questions remain surrounding the implementation of best practice education and support...
June 1, 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/29884169/pregnant-women-s-views-on-how-to-promote-the-use-of-a-decision-aid-for-down-syndrome-prenatal-screening-a-theory-informed-qualitative-study
#14
Titilayo Tatiana Agbadjé, Matthew Menear, Michèle Dugas, Marie-Pierre Gagnon, Samira Abbasgholizadeh Rahimi, Hubert Robitaille, Anik M C Giguère, François Rousseau, Brenda J Wilson, France Légaré
BACKGROUND: For pregnant women and their partners, the decision to undergo Down syndrome prenatal screening is difficult. Patient decision aids (PtDA) can help them make an informed decision. We aimed to identify behaviour change techniques (BCTs) that would be useful in an intervention to promote the use of a PtDA for Down syndrome prenatal screening, and to identify which of these BCTs pregnant women found relevant and acceptable. METHODS: Using the Behaviour Change Wheel and the Theoretical Domains Framework, we conducted a qualitative descriptive study...
June 8, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29882371/real-world-clinical-applicability-of-pathogenicity-predictors-assessed-on-serpina1-mutations-in-alpha-1-antitrypsin-deficiency
#15
Edoardo Giacopuzzi, Mattia Laffranchi, Romina Berardelli, Viola Ravasio, Ilaria Ferrarotti, Bibek Gooptu, Giuseppe Borsani, Annamaria Fra
The growth of publicly available data informing upon genetic variations, mechanisms of disease and disease sub-phenotypes offers great potential for personalised medicine. Computational approaches are likely required to assess large numbers of novel genetic variants. However, the integration of genetic, structural and pathophysiological data still represents a challenge for computational predictions and their clinical use. We addressed these issues for alpha-1-antitrypsin deficiency, a disease mediated by mutations in the SERPINA1 gene encoding alpha-1-antitrypsin...
June 7, 2018: Human Mutation
https://www.readbyqxmd.com/read/29877672/how-effective-is-the-integration-of-sport-and-exercise-medicine-in-the-english-national-health-service-for-sport-related-injury-treatment-and-health-management
#16
Emma Pullen, Dominic Malcolm, Patrick Wheeler
BACKGROUND: Regular participation in sport, exercise and physical activity is associated with positive health outcomes and form a mainstay of British public health policies. However, regular participation in sport and exercise can result in sport related injury (SRI) which, in turn, is a key cause of exercise cessation. The integration of Sport and Exercise Medicine (SEM) in the English National Health Service (NHS) aims to provide a specialist service for public populations and thus reduce the impact of SRI on exercise cessation and associated negative health outcomes...
June 7, 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29873132/perceived-support-for-medical-cannabis-use-among-approved-medical-cannabis-users-in-canada
#17
Cesar Leos-Toro, Samantha Shiplo, David Hammond
INTRODUCTION AND AIMS: Very little is known about the social experience of medical cannabis use, including the experience of stigma among approved users. The current study examined perceptions of support from physicians, family and friends as well as the prevalence of 'hiding' medicinal cannabis use. DESIGN AND METHODS: An online cross-sectional survey (N = 276) was conducted from 29 April to 8 June 2015. No public sampling frame was available from which to sample approved medical cannabis users (MCU)...
June 5, 2018: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29871651/effectiveness-and-sustainability-of-a-structured-group-based-educational-program-medihealth-in-improving-medication-adherence-among-malay-patients-with-underlying-type-2-diabetes-mellitus-in-sarawak-state-of-malaysia-study-protocol-of-a-randomized-controlled
#18
Chuo Yew Ting, Shahren Ahmad Zaidi Adruce, Mohamed Azmi Hassali, Hiram Ting, Chien Joo Lim, Rachel Sing-Kiat Ting, Abu Hassan Alshaari Abd Jabar, Nor Anizah Osman, Izzul Syazwan Shuib, Shing Chyi Loo, Sui Theng Sim, Su Ee Lim, Donald E Morisky
BACKGROUND: Amidst the high disease burden, non-adherence to medications among patients with type 2 diabetes mellitus (T2DM) has been reported to be common and devastating. Sarawak Pharmaceutical Services Division has formulated a pharmacist-led, multiple-theoretical-grounding, culturally sensitive and structured group-based program, namely "Know Your Medicine - Take if for Health" (MEDIHEALTH), to improve medication adherence among Malay patients with T2DM. However, to date, little is known about the effectiveness and sustainability of the Program...
June 5, 2018: Trials
https://www.readbyqxmd.com/read/29866918/how-mammals-stay-healthy-in-nature-the-evolution-of-behaviours-to-avoid-parasites-and-pathogens
#19
REVIEW
Benjamin L Hart, Lynette A Hart
Mammals live and thrive in environments presenting ongoing threats from parasites in the form of biting flies, ticks and intestinal worms and from pathogens as wound contaminants and agents of infectious disease. Several strategies have evolved that enable animals to deal with parasites and pathogens, including eliminating away from the sleeping-resting areas, use of an array of grooming techniques, use of saliva in licking, and consuming medicinal plant-based compounds. These strategies all are species-specific and reflect the particular environment that the animal inhabits...
July 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29858128/allopathic-ayush-and-informal-medical-practitioners-in-rural-india-a-prescription-for-change
#20
REVIEW
Shailaja Chandra, Kishor Patwardhan
This paper looks at the treatment seeking behaviour of rural households and presents factors that discourage them from using public health facilities. It also brings out how Allopathic medical graduates as well as institutionally qualified AYUSH doctors predominantly offer services in cities and townships which results in lakhs of village households having to depend on unqualified medical practitioners as the first line of medical treatment; also how this situation will continue unless the approach to providing medical treatment is modified...
May 29, 2018: Journal of Ayurveda and Integrative Medicine
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