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https://www.readbyqxmd.com/read/28805512/chronic-fatigue-syndrome-patients-have-no-reason-to-accept-the-pace-trial-results-response-to-keith-j-petrie-and-john-weinman
#1
Susanna Agardy
Petrie and Weinman urge chronic fatigue syndrome patients to move on from their beliefs about their illness and accept the findings of thePACE trial. This is unreasonable in view of the failure of PACE to achieve evidence of recovery through cognitive behaviour therapy and graded exercise therapy in either self-reports or the objective measure of the 6-minute walking test. Contrary to their suggestion, the Institute of Medicine describes chronic fatigue syndrome not as psychological but as a serious, chronic, systemic disease, with post-exertional malaise as its main feature which inhibits exercise...
August 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28803534/moving-rehabilitation-research-forward-developing-consensus-statements-for-rehabilitation-and-recovery-research
#2
Julie Bernhardt, Karen Borschmann, Lara Boyd, S Thomas Carmichael, Dale Corbett, Steven C Cramer, Tammy Hoffmann, Gert Kwakkel, Sean Savitz, Gustavo Saposnik, Marion Walker, Nick Ward
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and recovery research is exponential, a number of barriers hamper our ability to rapidly progress the field. Standardized terminology is absent in both animal and human research, methods are poorly described, recovery biomarkers are not well defined, and we lack consistent timeframes or measures to examine outcomes. Agreed methods and conventions for developing, monitoring, evaluating and reporting interventions directed at improving recovery are lacking, and current approaches are often not underpinned by biology...
August 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/28801423/comparative-efficacy-and-acceptability-of-antidepressants-psychological-interventions-and-their-combination-for-depressive-disorder-in-children-and-adolescents-protocol-for-a-network-meta-analysis
#3
Xinyu Zhou, Andrea Cipriani, Yuqing Zhang, Pim Cuijpers, Sarah E Hetrick, John R Weisz, Juncai Pu, Cinzia Del Giovane, Toshiaki A Furukawa, Jürgen Barth, David Coghill, Stefan Leucht, Lining Yang, Arun V Ravindran, Peng Xie
INTRODUCTION: Depressive disorder is common in children and adolescents, with important consequences and serious impairments in terms of personal and social functioning. While both pharmacological and psychological interventions have been shown to be effective, there is still uncertainty about the balance between these and what treatment strategy should be preferred in clinical practice. Therefore, we aim to compare and rank in a network meta-analysis (NMA) the commonly used psychological, pharmacological and combined interventions for depressive disorder in children and adolescents...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801402/reasons-for-non-adherence-to-cardiometabolic-medications-and-acceptability-of-an-interactive-voice-response-intervention-in-patients-with-hypertension-and-type-2-diabetes-in-primary-care-a-qualitative-study
#4
Aikaterini Kassavou, Stephen Sutton
OBJECTIVES: This study explored the reasons for patients' non-adherence to cardiometabolic medications, and tested the acceptability of the interactive voice response (IVR) as a way to address these reasons, and support patients, between primary care consultations. DESIGN, METHOD, PARTICIPANTS AND SETTING: The study included face-to-face interviews with 19 patients with hypertension and/or type 2 diabetes mellitus, selected from primary care databases, and presumed to be non-adherent...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801393/protocol-for-the-mwellcare-trial-a-multicentre-cluster-randomised-12-month-controlled-trial-to-compare-the-effectiveness-of-mwellcare-an-mhealth-system-for-an-integrated-management-of-patients-with-hypertension-and-diabetes-versus-enhanced-usual-care-in-india
#5
Dilip Jha, Priti Gupta, Vamadevan S Ajay, Devraj Jindal, Pablo Perel, David Prieto-Merino, Pramod Jacob, Jonathan Nyong, Vidya Venugopal, Kavita Singh, Shifalika Goenka, Ambuj Roy, Nikhil Tandon, Vikram Patel, Dorairaj Prabhakaran
INTRODUCTION: Rising burden of cardiovascular disease (CVD) and diabetes is a major challenge to the health system in India. Innovative approaches such as mobile phone technology (mHealth) for electronic decision support in delivering evidence-based and integrated care for hypertension, diabetes and comorbid depression have potential to transform the primary healthcare system. METHODS AND ANALYSIS: mWellcare trial is a multicentre, cluster randomised controlled trial evaluating the clinical and cost-effectiveness of a mHealth system and nurse managed care for people with hypertension and diabetes in rural India...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28799382/kinetics-of-spontaneous-filament-nucleation-via-oligomers-insights-from-theory-and-simulation
#6
Anđela Šarić, Thomas C T Michaels, Alessio Zaccone, Tuomas P J Knowles, Daan Frenkel
Nucleation processes are at the heart of a large number of phenomena, from cloud formation to protein crystallization. A recently emerging area where nucleation is highly relevant is the initiation of filamentous protein self-assembly, a process that has broad implications in many research areas ranging from medicine to nanotechnology. As such, spontaneous nucleation of protein fibrils has received much attention in recent years with many theoretical and experimental studies focussing on the underlying physical principles...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28797262/when-a-parent-dies-a-systematic-review-of-the-effects-of-support-programs-for-parentally-bereaved-children-and-their-caregivers
#7
Ann-Sofie Bergman, Ulf Axberg, Elizabeth Hanson
BACKGROUND: The death of a parent is a highly stressful life event for bereaved children. Several studies have shown an increased risk of mental ill-health and psychosocial problems among affected children. The aims of this study were to systematically review studies about effective support interventions for parentally bereaved children and to identify gaps in the research. METHODS: The review's inclusion criteria were comparative studies with samples of parentally bereaved children...
August 10, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28797002/is-medicine-use-for-nervousness-associated-with-adolescent-at-risk-or-problem-gambling
#8
Natale Canale, Alessio Vieno, Joël Billieux, Giacomo Lazzeri, Patrizia Lemma, Massimo Santinello
OBJECTIVE: To examine the association between adolescent at-risk or problem gambling (ARPG) and medicine used to treat nervousness in a large-scale nationally representative sample of Italian adolescents. STUDY DESIGN: Data from the 2013/2014 Health Behaviour in School-aged Children Survey was used for cross-sectional analyses (a sample of 20,791 15-year-old students). Self-administered questionnaires were completed by a representative sample of high-school students...
August 11, 2017: European Addiction Research
https://www.readbyqxmd.com/read/28795460/how-do-people-conceptualise-the-reuse-of-medicines-an-interview-study
#9
Hamza Alhamad, Nilesh Patel, Parastou Donyai
OBJECTIVES: To capture people's beliefs about medicines reuse and to map the determinants of intentions to reuse medicines in the future. METHODS: Participants were recruited through an advert placed in the university's community newsletter reaching 15 000 households. Adults wishing to participate were interviewed using convenience sampling, with recruitment continuing until data saturation. Participants were interviewed face-to-face by two researchers using a semi-structured interview schedule based on the theory of planned behaviour (TPB)...
August 9, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28793809/-these-people-who-dig-roots-in-the-forests-cannot-treat-hiv-women-and-men-in-durban-south-africa-reflect-on-traditional-medicine-and-antiretroviral-drugs
#10
Amy Weintraub, Joanne E Mantell, Kelsey Holt, Renée A Street, Catriona Wilkey, Suraya Dawad, Tsitsi B Masvawure, Susie Hoffman
Relatively few empirical investigations of the intersection of HIV biomedical and traditional medicine have been undertaken. As part of preliminary work for a longitudinal study investigating health-seeking behaviours among newly diagnosed individuals living with HIV, we conducted semi-structured interviews with 24 urban South Africans presenting for HIV testing or newly enrolled in HIV care; here we explored participants' views on African traditional medicine (TM) and biomedical HIV treatment. Notions of acceptance/non-acceptance were more nuanced than dichotomous, with participants expressing views ranging from favourable to reproachful, often referring to stories they had heard from others rather than drawing from personal experience...
August 10, 2017: Global Public Health
https://www.readbyqxmd.com/read/28792412/evolutionary-public-health-introducing-the-concept
#11
REVIEW
Jonathan C K Wells, Randolph M Nesse, Rebecca Sear, Rufus A Johnstone, Stephen C Stearns
The emerging discipline of evolutionary medicine is breaking new ground in understanding why people become ill. However, the value of evolutionary analyses of human physiology and behaviour is only beginning to be recognised in the field of public health. Core principles come from life history theory, which analyses the allocation of finite amounts of energy between four competing functions-maintenance, growth, reproduction, and defence. A central tenet of evolutionary theory is that organisms are selected to allocate energy and time to maximise reproductive success, rather than health or longevity...
July 29, 2017: Lancet
https://www.readbyqxmd.com/read/28779931/indonesian-provisional-clinical-psychologists-knowledge-attitudes-and-behaviours-towards-complementary-alternative-medicine-cam
#12
Andrian Liem, Peter A Newcombe
Sixty provisional clinical psychologists in Indonesia were emailed to seek their participation in an online-questionnaire that reflected: CAM knowledge, attitudes CAM, and CAM behaviours. Of the 60 participants approached, 44 with majority of female (95%) completed the questionnaire. The mean age of participants was 25 years. Overall, participants reported low knowledge of CAM and attitudes towards CAM were positive. While 73% reported having recommended CAM to their clients, only 39% had ever made referral...
August 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/28771860/the-nexus-of-nursing-leadership-and-a-culture-of-safer-patient-care
#13
Melanie Murray, Deborah Sundin, Vicki Cope
AIMS AND OBJECTIVES: To explore the connection between+6 nursing leadership and enhanced patient safety. BACKGROUND: Critical reports from the Institute of Medicine in 1999 and Francis QC report of 2013 indicate that healthcare organisations, inclusive of nursing leadership, were remiss or inconsistent in fostering a culture of safety. The factors required to foster organisational safety culture include supportive leadership, effective communication, an orientation program and ongoing training, appropriate staffing, open communication regarding errors, compliance to policy and procedure, and environmental safety and security...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28765124/demographic-and-behavioural-risk-factors-associated-with-trichomonas-vaginalis-among-south-african-hiv-positive-men-with-genital-ulcer-disease-a-cross-sectional-study
#14
Iddrisu Abdallah, Elizabeth Armstrong-Mensah, Ernest Alema-Mensah, Cheryl Jones
OBJECTIVES: Demographic and risky sexual behaviours may increase the risk for Trichomonas vaginalis (TV) infection and, thus, enhance HIV transmission to uninfected partners. We assessed the demographic and behavioural risk factors associated with TV among South African HIV-positive men with genital ulcer disease. METHODS: We conducted a cross-sectional study with data from a randomised controlled trial conducted by the Centers for Disease Control and Prevention and the London School of Hygiene and Tropical Medicine...
August 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28762651/provision-of-pharmaceutical-care-by-community-pharmacists-across-europe-is-it-developing-and-spreading
#15
Filipa A Costa, Claire Scullin, Ghaith Al-Taani, Ahmed F Hawwa, Claire Anderson, Zinaida Bezverhni, Zahida Binakaj, Maria Cordina, Veerle Foulon, Borja Garcia de Bikuña, Han de Gier, Anne Gerd Granås, Olga Grinstova, Nina Griese-Mammen, Jonas Grinceviciene, Svitrigaile Grinceviciene, Susanne Kaae, Loreta Kubiliene, Eduardo L Mariño, Silvia Martins, Pilar Modamio, Giancarlo Nadin, Lotte Stig Nørgaard, Emina Obarcanin, Ivana Tadic, Ljiljana Tasic, James C McElnay, Kurt E Hersberger, Tommy Westerlund
RATIONALE, AIMS, AND OBJECTIVES: Pharmaceutical care involves patient-centred pharmacist activity to improve medicines management by patients. The implementation of this service in a comprehensive manner, however, requires considerable organisation and effort, and indeed, it is often not fully implemented in care settings. The main objective was to assess how pharmaceutical care provision within community pharmacy has evolved over time in Europe. METHOD: A cross-sectional questionnaire-based survey of community pharmacies, using a modified version of the Behavioural Pharmaceutical Care Scale (BPCS) was conducted in late 2012/early 2013 within 16 European countries and compared with an earlier assessment conducted in 2006...
August 1, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28761599/factors-associated-with-severe-malaria-among-children-below-ten-years-in-mutasa-and-nyanga-districts-zimbabwe-2014-2015
#16
Faith Mutsigiri-Murewanhema, Patron Trish Mafaune, Gerald Shambira, Tsitsi Juru, Donewell Bangure, More Mungati, Notion Tafara Gombe, Mufuta Tshimanga
INTRODUCTION: Severe malaria is a rare life threatening illness. Only a small proportion of patients with clinical malaria progress to this medical emergency. On reviewing 61 malaria death investigation forms submitted to the provincial office in 2014, 22(36%) were children below ten years who succumbed to severe malaria. Mutasa and Nyanga Districts reported 73% of these deaths. This study was conducted to determine factors associated with severe malaria so as to come up with evidence based interventions to prevent severe malaria and associated mortality...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28748106/a-feasibility-study-of-a-theory-based-intervention-to-improve-appropriate-polypharmacy-for-older-people-in-primary-care
#17
Cathal A Cadogan, Cristín Ryan, Gerard J Gormley, Jill J Francis, Peter Passmore, Ngaire Kerse, Carmel M Hughes
BACKGROUND: A general practitioner (GP)-targeted intervention aimed at improving the prescribing of appropriate polypharmacy for older people was previously developed using a systematic, theory-based approach based on the UK Medical Research Council's complex intervention framework. The primary intervention component comprised a video demonstration of a GP prescribing appropriate polypharmacy during a consultation with an older patient. The video was delivered to GPs online and included feedback emphasising the positive outcomes of performing the behaviour...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28743970/adme-space-a-new-tool-for-medicinal-chemists-to-explore-adme-properties
#18
Giovanni Bocci, Emanuele Carosati, Philippe Vayer, Alban Arrault, Sylvain Lozano, Gabriele Cruciani
We introduce a new chemical space for drugs and drug-like molecules, exclusively based on their in silico ADME behaviour. This ADME-Space is based on self-organizing map (SOM) applied to 26,000 molecules. Twenty accurate QSPR models, describing important ADME properties, were developed and, successively, used as new molecular descriptors not related to molecular structure. Applications include permeability, active transport, metabolism and bioavailability studies, but the method can be even used to discuss drug-drug interactions (DDIs) or it can be extended to additional ADME properties...
July 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743094/a-personalized-medicine-approach-to-the-design-of-dry-powder-inhalers-selecting-the-optimal-amount-of-bypass
#19
Thomas Kopsch, Darragh Murnane, Digby Symons
In dry powder inhalers (DPIs) the patient's inhalation manoeuvre strongly influences the release of drug. Drug release from a DPI may also be influenced by the size of any air bypass incorporated in the device. If the amount of bypass is high less air flows through the entrainment geometry and the release rate is lower. In this study we propose to reduce the intra- and inter-patient variations of drug release by controlling the amount of air bypass in a DPI. A fast computational method is proposed that can predict how much bypass is needed for a specified drug delivery rate for a particular patient...
July 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28735830/-i-just-googled-and-read-everything-exploring-breast-cancer-survivors-use-of-the-internet-to-find-information-on-complementary-medicine
#20
Michelle M Holmes, Felicity L Bishop, Lynn Calman
OBJECTIVE: Breast cancer survivors often turn to the internet as an information resource when deciding whether to use complementary and alternative medicine (CAM) but their use of online CAM-related resources is poorly understood. The objective was to explore breast cancer survivors' use of the internet when making decisions about CAM use. DESIGN: A purposive sample of 11 breast cancer survivors (mean age=56) completed a quantitative questionnaire and a qualitative telephone interview...
August 2017: Complementary Therapies in Medicine
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