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Gallium 68

Karine A Al Feghali, Debra N Yeboa, Beth Chasen, Maria K Gule, Jason M Johnson, Caroline Chung
We hereby report the case of a patient with optic nerve sheath meningioma (ONSM), whose diagnosis and multidisciplinary management was guided by the use of Gallium-68 (68 Ga)-labeled dodecanetetraacetic acid-tyrosine-3-octreotate (DOTATATE) positron emission tomography (PET)/computed tomography (CT) scan. We briefly review the diagnosis and management of ONSM, and review the literature on the role and current status of nuclear imaging with somatostatin receptor ligands in the non-invasive diagnosis and management of meningiomas...
2018: Frontiers in Oncology
Francesco Ceci, Paolo Castellucci, Tiziano Graziani, Andrea Farolfi, Cristina Fonti, Filippo Lodi, Stefano Fanti
OBJECTIVES: The primary objective was the evaluation of Gallium 68 (68 Ga)-prostate-specific membrane antigen (PSMA)-11 positron emission tomography/computed tomography (PET/CT) detection rate, for identifying the site of prostate cancer (PCa) relapse (local vs systemic), stratifying the population according to different clinical stages of biochemical recurrence (BCR). Secondary aims were: 1) to evaluate the association of clinical/pathologic features and 68 Ga-PSMA-11 PET/CT detection rate, 2) to compare 68 Ga-PSMA-11 PET/CT with other imaging procedures, and 3) to evaluate the positive predictive value (PPV) in a per-patient analysis...
October 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Max L Senders, Sophie Hernot, Giuseppe Carlucci, Jan C van de Voort, Francois Fay, Claudia Calcagno, Jun Tang, Amr Alaarg, Yiming Zhao, Seigo Ishino, Anna Palmisano, Gilles Boeykens, Anu E Meerwaldt, Brenda L Sanchez-Gaytan, Samantha Baxter, Laura Zendman, Mark E Lobatto, Nicolas A Karakatsanis, Philip M Robson, Alexis Broisat, Geert Raes, Jason S Lewis, Sotirios Tsimikas, Thomas Reiner, Zahi A Fayad, Nick Devoogdt, Willem J M Mulder, Carlos Pérez-Medina
OBJECTIVES: This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers. BACKGROUND: Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations of current diagnostic methods demonstrate that, in addition to atherosclerotic plaque morphology and composition, disease activity needs to be evaluated...
October 12, 2018: JACC. Cardiovascular Imaging
Jesse Pulido, Maria de Cabrera, Adam J Sobczak, Alejandro Amor-Coarasa, Anthony J McGoron, Stanislaw F Wnuk
The conjugation of 4-N-(3-aminopropanyl)-2'-deoxy-2',2'-difluorocytidine with 2-(p-isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (SCN-Bn-NOTA) ligand in 0.1 M Na2 CO3 buffer (pH 11) at ambient temperature provided 4-N-alkylgemcitabine-NOTA chelator. Incubation of latter with excess of gallium(III) chloride (GaCl3 ) (0.6 N AcONa/H2 O, pH = 9.3) over 15 min gave gallium 4-N-alkylgemcitabine-NOTA complex which was characterized by HRMS. Analogous [68 Ga]-complexation of 4-N-alkylgemcitabine-NOTA conjugate proceeded with high labeling efficiency (94%-96%) with the radioligand almost exclusively found in the aqueous layer (∼95%)...
October 12, 2018: Bioorganic & Medicinal Chemistry
Adam J Smith, Peter J Gawne, Michelle T Ma, Philip J Blower, Richard Southworth, Nicholas J Long
Radiolabelled lipophilic cations that accumulate in mitochondria according to the magnitude of the mitochondrial membrane potential can be used to report non-invasively on mitochondrial dysfunction in cardiovascular disease, cardiotoxicity, and cancer. While several such cations are already commercially available for SPECT imaging, PET offers greater promise in terms of sensitivity, resolution, and capacity for dynamic imaging and pharmacokinetic modelling. We have therefore synthesised a series of three triarylphosphonium-functionalised DO3A chelators for positron emitter gallium-68, with differing alkyl-functionalisation motifs to provide opportunities for tunable lipophilicity as a means of optimising their pharmacokinetics...
October 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Dominik Summer, Sonja Mayr, Milos Petrik, Christine Rangger, Katia Schoeler, Lisa Vieider, Barbara Matuszczak, Clemens Decristoforo
The inverse electron-demand Diels-Alder reaction between 1,2,4,5-tetrazine (Tz) and trans -cyclooct-2-ene (TCO) has gained increasing attraction among extensive studies on click chemistry due to its exceptionally fast reaction kinetics and high selectivity for in vivo pretargeting applications including PET imaging. The facile two-step approach utilizing TCO-modified antibodies as targeting structures has not made it into clinics yet. An increase in the blood volume of humans in comparison to mice seems to be the major limitation...
October 11, 2018: Pharmaceuticals
Amarnath Jena, Rajesh Taneja, Sangeeta Taneja, Aru Singh, Venkatesh Kumar, Anshuman Agarwal, Narasimhan Subramanian
OBJECTIVE: The current study was designed to test the diagnostic performance of 68 Ga-prostate-specific membrane antigen (PSMA) PET and multiparametric MRI along with clinical parameters in the characterization of prostatic lesions. MATERIALS AND METHODS: Eighty-two men with 63 malignant and 21 benign histologically proven prostate lesions who underwent complete clinical workup were included in this retrospective study. All patients underwent simultaneous whole-body 68 Ga-PSMA PET/MRI with dedicated multiparametric MRI...
October 9, 2018: AJR. American Journal of Roentgenology
Sophie Knipper, Derya Tilki, Joost Mansholt, Christoph Berliner, Christian Bernreuther, Thomas Steuber, Tobias Maurer, Markus Graefen
The first results on 99m Technetium prostate-specific membrane antigen-radioguided surgery (99m Tc-PSMA- RGS) showed promising outcome. Here, we sought to evaluate if this targeted molecular surgical approach might be more effective than conventional salvage lymph node dissection (sLND). We prospectively analysed 42 consecutive patients who underwent sLND based on preoperative 68 Gallium (68 Ga)-PSMA-positron emission tomography (PET) imaging between 2015 and 2018. In 29 patients, the dissection field was based solely 68 Ga-PSMA-PET imaging (conventional surgical approach [CSA]), whereas 13 patients underwent 99m Tc-PSMA-RGS...
October 3, 2018: European Urology Focus
Martin Barrio, Eugene P Ceppa
Neuroendocrine tumors (NETs) are an uncommon diagnosis which often present asymptomatically or with vague symptoms. They can originate from many different organs such as the GI tract, lungs, pancreas and others. 68 Gallium DOTATATE positron emission topography/computed topography has been shown to be an effective imaging modality for diagnosing NET and evaluating management options for patients. Here, we present two cases of positive findings in the distal pancreas on the DOTATATE PET/CT scans without any morphological lesion found to be NET in a healthy 48-year-old male and 68-year-old male...
September 2018: Journal of Surgical Case Reports
Mustapha El Lakis, Andreas Gianakou, Pavel Nockel, Douglas Wiseman, Amit Tirosh, Martha A Quezado, Dhaval Patel, Naris Nilubol, Karel Pacak, Samira M Sadowski, Electron Kebebew
Importance: Neuroendocrine tumors (NETs) express somatostatin receptors, which can be targeted with radiolabeled peptides. In a variety of solid tumors, radioguided surgery (RGS) has been used to guide surgical resection. Gallium 68 (68Ga) dota peptides have been shown to be more accurate than other radioisotopes for detecting NETs. A pilot study previously demonstrated the feasibility and safety of 68Ga-dotatate RGS for patients with NETs. Objective: To evaluate what intraoperative techniques and thresholds define positive lesions that warrant resection during 68Ga-dotatate RGS...
September 26, 2018: JAMA Surgery
Chester E Chamberlain, Michael S German, Katherine Yang, Jason Wang, Henry VanBrocklin, Melanie Regan, Kevan M Shokat, Gregory S Ducker, Grace E Kim, Byron Hann, David B Donner, Robert S Warren, Alan P Venook, Emily K Bergsland, Danny Lee, Yucheng Wang, Eric K Nakakura
Patients with pancreatic neuroendocrine tumors (PNETs) commonly develop advanced disease and require systemic therapy. However, treatment options remain limited, in part because experimental models that reliably emulate PNET disease are lacking. We therefore developed a patient-derived xenograft model of PNET (PDX-PNET) which we then used to evaluate two mTOR inhibitor drugs: FDA-approved everolimus and the investigational new drug sapanisertib. PDX-PNETs maintained a PNET morphology and PNET-specific gene expression signature with serial passage...
September 25, 2018: Molecular Cancer Therapeutics
Robert M Hicks, Jeffry P Simko, Antonio C Westphalen, Hao G Nguyen, Kirsten L Greene, Li Zhang, Peter R Carroll, Thomas A Hope
Purpose To compare the diagnostic accuracy of gallium 68 (68 Ga)-labeled prostate-specific membrane antigen (PSMA)-11 PET/MRI with that of multiparametric MRI in the detection of prostate cancer. Materials and Methods The authors performed a retrospective study of men with biopsy-proven prostate cancer who underwent simultaneous 68 Ga-PSMA-11 PET/MRI before radical prostatectomy between December 2015 and June 2017. The reference standard was whole-mount pathologic examination. Readers were blinded to radiologic and pathologic findings...
September 18, 2018: Radiology
Arun Sasikumar, Ajith Joy, Ambikalmajan M R Pillai, Karuna E Oommen, Sudin Somarajan, Vikraman Kaithavelil Raman, Renu Thomas, Dhanya Dinesh
OBJECTIVE: To assess the feasibility of gallium 68 (Ga)-prostate specific membrane antigen (PSMA) PET/computed tomography (CT) to identify patients who truly harbor clinically significant prostate cancer (PCa) in a cohort of patients with clinical and biochemical/radiological suspicion of PCa. PATIENTS AND METHODS: A total of 118 patients with suspected PCa who underwent Ga-PSMA PET/CT between May 2015 and June 2016 were prospectively included. Final decision on performing biopsy was left to the referring urologist after considering the clinical data, scan findings and discussion with the patient...
November 2018: Nuclear Medicine Communications
Nader Hirmas, Akram Al-Ibraheem, Ken Herrmann, Abedalatif Alsharif, Haider Muhsin, Jamal Khader, Ali Al-Daghmin, Samer Salah
PURPOSE: In this retrospective study, we compared the diagnostic value of 68 Gallium prostate-specific membrane antigen positron emission tomography computed tomography ([68 Ga]PSMA PET/CT) in primary staging of patients with high-risk prostate cancer (PCa), in comparison to CT, magnetic resonance imaging (MRI), and bone scans, and we explored its overall impact on patients' management plan. PROCEDURES: Patients with pathological confirmation of PCa with high-risk disease were included in this study...
September 13, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Banafsheh Motazedi, Maziar Rahmani, James M Welch, Abbas Motazedi
A 77-year-old woman was diagnosed with pheochromocytoma followed by adrenalectomy at age 57. Hyperparathyroidism without osteoprosis was diagnosed at age 58. At age 75, Dual Energy X-ray Absoptiometry (DEXA) revealed osteoporosis and sestamibi scan showed a left parathyroid adenoma. Criteria for parathyroidectomy were met, and she underwent parathyroidectomy. Furthermore, she presented with haematochezia at age 75. An abdominal CT demonstrated a mass in the second portion of the duodenum. Additionally, octreoscan revealed somatostatin receptor positive tissue in the duodenum and Gallium 68 dotatate scan also showed a well-differentiated duodenal neuroendocrine tumour (NET)...
September 4, 2018: BMJ Case Reports
Eva Dyrberg, Helle W Hendel, Tri Hien Viet Huynh, Tobias Wirenfeldt Klausen, Vibeke B Løgager, Claus Madsen, Erik M Pedersen, Maria Pedersen, Henrik S Thomsen
OBJECTIVES: To determine the diagnostic accuracy of 68 gallium prostate-specific membrane antigen (PSMA)-based positron emission tomography/computed tomography (PET/CT) in comparison with 18 F-fluoride-based PET/CT (NaF-PET/CT) and whole-body magnetic resonance imaging (WB-MRI) for the detection of bone metastases in patients with prostate cancer. METHODS: Sixty patients with prostate cancer were included in the period May 2016 to June 2017. The participants underwent three scans (index tests) within 30 days: a NaF-PET/CT, a WB-MRI and a PSMA-PET/CT...
August 21, 2018: European Radiology
Jasmine Shell, Xavier M Keutgen, Corina Millo, Naris Nilubol, Dhaval Patel, Samira Sadowski, Myriem Boufraqech, Lily Yang, Roxanne Merkel, Christine Atallah, Peter Herscovitch, Electron Kebebew
Aim: The study's aim was to determine the utility of 68-Gallium DOTATATE positron emission tomography (PET)-CT scanning in patients with carcinoid-like symptoms and negative anatomical imaging. Methods: Retrospective analysis of 22 of 196 patients with carcinoid-like symptoms and no evidence of primary neuroendocrine tumor (NET) based on anatomical imaging and endoscopy who underwent 68-Gallium DOTATATE PET-CT as part of a prospective clinical trial. Results: Of the biochemically positive patients (n = 11), 18% (n = 2) had additional evidence of NETs based on 68-Gallium DOTATATE PET-CT...
February 2018: International Journal of Endocrine Oncology
Stephen Thompson, Melissa E Rodnick, Jenelle Stauff, Janna Arteaga, Timothy J Desmond, Peter J H Scott, Benjamin L Viglianti
Radiolabeled erythrocytes have multiple applications in nuclear medicine, including blood pool imaging. Historically they have been labeled with SPECT radionuclides. A PET blood pool imaging agent is highly desirable as it would improve clinical applications with better image quality and resolution, higher sensitivity, and dynamic scanning capabilities. With the coming of age of modern 68 Ge/68 Ga generator systems, gallium-68 is now widely accessible. In this paper we describe an updated method for the preparation of 68 Ga-labeled erythrocytes and their preliminary use in rodent blood pool imaging...
March 1, 2018: MedChemComm
E David Crawford, Phillip J Koo, Neal Shore, Susan F Slovin, Raoul S Concepcion, Stephen J Freedland, Leonard G Gomella, Lawrence Karsh, Thomas E Keane, Paul Maroni, David Penson, Daniel P Petrylak, Ashley Ross, Vlad Mouraviev, Robert E Reiter, Chaitanya Divgi, Evan Y Yu
PURPOSE: The advanced prostate cancer therapeutic landscape has changed dramatically over the last several years, resulting in improved overall survival for patients with both castration-naive and castration-resistant disease. The evolution and development of novel next generation imaging (NGI) techniques will affect diagnostic and therapeutic decision-making. Clinicians must navigate when and which NGI techniques to use and how to adjust treatment strategies based upon their results, oftentimes in the absence of correlative therapeutic data...
August 2, 2018: Journal of Urology
Sean S Tanzey, Stephen Thompson, Peter Jh Scott, Allen F Brooks
Commercial 68 Ge/68 Ga generators provide a means to produce positron emission tomography agents on site without use of a cyclotron. This development has led to a rapid growth of academic literature and patents ongallium-68 (68 Ga). As 68 Ga positron emission tomography agents usually involve a targeting moiety attached to a metal chelator, the development lends itself to the investigation of theragnostic applications; the 68 Ga-based diagnostic is utilized to determine if the biological target is present and, if so, a therapeutic isotope (e...
September 2018: Pharmaceutical Patent Analyst
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