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Gallium 68

Alban Revy, François Hallouard, Sandrine Joyeux-Klamber, Andrea Skanjeti, Catherine Rioufol, Marc Fraysse
OBJECTIVE: Recent gallium-68 labeled peptides are of increasing interest for PET imaging in nuclear medicine. Somakit TOC® is a radiopharmaceutical kit registered in the European Union for the preparation of [68Ga]Ga-DOTA-TOC used for the diagnosis of neuroendocrine tumors. Development of a labeling process using a synthesizer is particularly interesting for quality and reproducibility of the final product although only manual processes are described in the Summary of Product (SmPC) of the registered product...
January 10, 2019: Current Radiopharmaceuticals
Yusuke Yagi, Yoichi Shimizu, Kenji Arimitsu, Yuji Nakamoto, Takahiro Higuchi, Kaori Togashi, Hiroyuki Kimura
Gallium-68 (68 Ga, t1/2 = 68 min) can be easily obtained from a 68 Ge/68 Ga generator and several such systems are commercially available. The use of positron emission tomography (PET) imaging using 68 Ga-labeled radiopharmaceuticals is expected to increase in both preclinical and clinical settings. However, the chelation between a 68 Ga cation and the bifunctional macrocyclic chelates that are used for labeling bioactive substances, such as 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), requires a relatively long reaction time and high temperature to achieve a high radiochemical yield...
January 2, 2019: Journal of Labelled Compounds & Radiopharmaceuticals
Atsushi Ishizaki, Kenji Mishiro, Kazuhiro Shiba, Hirofumi Hanaoka, Seigo Kinuya, Akira Odani, Kazuma Ogawa
OBJECTIVE: Somatostatin receptors are highly expressed in neuroendocrine tumors, and many radiolabeled somatostatin analogs for diagnosis and treatment have been developed. To simultaneously detect not only primary cancer but also bone metastases, this study aimed to develop a positron emission tomography probe using generator-produced nuclide Gallium-68 (T1/2 = 68 min), in which a carrier for primary cancer, a carrier for bone metastases lesions, and a stable gallium complex are introduced into the one molecule...
January 3, 2019: Annals of Nuclear Medicine
Deepa Shetty, Dhruv Patel, Ken Le, Chuong Bui, Robert Mansberg
The novel Gallium-68 prostate-specific membrane antigen (PSMA)-bis [2-hydroxy-5-(carboxyethyl)benzyl] ethylenediamine-diacetic acid positron emission tomography (PET) tracer is increasingly used in the evaluation of prostate cancer, particularly in the detection of recurrent disease. However, PSMA is expressed in nonprostatic tissues, as well as in other pathologic conditions. Here we illustrate such interpretive pitfalls with relevant images that one may encounter while reporting PSMA PET/CT. This study aims to show variation in physiological distribution of PSMA activity and uptake in various benign and neoplastic disorders that may be misinterpreted as prostatic metastatic disease...
December 2018: Tomography: a Journal for Imaging Research
Pierre-François Montoriol, Claire Boudinaud
We present a rare case of large bilateral ovarian tumours, secondarily revealing an ileal neuroendocrine tumour in a 71-year-old woman. Magnetic resonance examination showed bilateral ovarian, entirely solid lesions with a fibrous content and marked enhancement. Computed tomography was able to show a mesenteric retractile mass and a satellite suspicious ileal wall thickening. Gallium-68 DOTATOC confirmed the suspicion of digestive neuroendocrine tumour metastatic to the ovaries and the final diagnosis was made following radical surgery...
December 26, 2018: Journal of Medical Imaging and Radiation Oncology
Kuo-Ting Chen, Kevin Nguyen, Christian Ieritano, Feng Gao, Yann Seimbille
We herein describe a flexible synthesis of a small library of 68 Ga-labeled CAIX-targeted molecules via an orthogonal 2-cyanobenzothiazole (CBT)/1,2-aminothiol click reaction. Three novel CBT-functionalized chelators ( 1 ⁻ 3 ) were successfully synthesized and labeled with the positron emitter gallium-68. Cross-ligation between the pre-labeled bifunctional chelators (BFCs) and the 1,2-aminothiol-acetazolamide derivatives ( 8 and 9 ) yielded six new 68 Ga-labeled CAIX ligands with high radiochemical yields...
December 21, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Nina-Sophie Schmidt-Hegemann, Eze Chukwuka, Li Minglun, Paul Rogowski, Christian Schaefer, Christian Stief, Alexander Buchner, Constantinos Zamboglou, Wolfgang P Fendler, Ute Ganswindt, Clemens Cyran, Peter Bartenstein, Claus Belka, Harun Ilhan
68 Gallium-prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) offers unprecedented accuracy for staging of primary, persistent or recurrent prostate cancer. Thus, we hypothesized that PSMA PET/CT prior to radiotherapy significantly impacts the radiotherapeutic approach in comparison to the current standard of CT based approach. Methods: Between February 2014 and December 2017, a total of 172 patients received PSMA PET/CT before radiotherapy and were included in this retrospective analysis...
December 14, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Pierre-Yves Le Roux, Rodney J Hicks, Shankar Siva, Michael S Hofman
Ventilation/Perfusion (V/Q) positron emission tomography computed tomography (PET/CT) is now possible by substituting Technetium-99m (99m Tc) with Gallium-68 (68 Ga), using the same carrier molecules as conventional V/Q imaging. Ventilation imaging can be performed with 68 Ga-carbon nanoparticles using the same synthesis device as Technegas. Perfusion imaging can be performed with 68 Ga-macroaggregated albumin. Similar physiological processes can therefore be evaluated by either V/Q SPECT/CT or PET/CT. However, V/Q PET/CT is inherently a superior technology for image acquisition, with higher sensitivity, higher spatial and temporal resolution, and superior quantitative capability, allowing more accurate delineation and quantification of regional lung function...
January 2019: Seminars in Nuclear Medicine
Manoj Gupta, Partha Sarathi Choudhury, Sudhir Rawal, Harish Chandra Goel, S Avinash Rao
Purpose: The aim of the study was to compare response evaluation criteria in solid tumours 1.1 (RECIST 1.1), positron emission tomography response criteria in solid tumours (PERCIST), European organisation for research and treatment of cancer (EORTC), and MD Anderson (MDA) criteria for response assessment by Gallium 68-prostate-specific membrane antigen positron emission tomography-computed tomography (Ga68-PSMA PET-CT) in metastatic adenocarcinoma prostate cancer (mPCa) patients with biochemical progression...
December 2018: Nuclear Medicine and Molecular Imaging
Jose M Anton-Rodriguez, Georgios Krokos, Fotis Kotasidis, Marie-Claude Asselin, Olivia Morris, Peter Julyan, Anthony Archer, Julian C Matthews
In this work we compare spatially variant radioisotope-specific point spread functions (PSFs) derived from published positron range data with measured data using a high resolution research tomograph (HRRT). Spatially variant PSFs were measured on a HRRT for fluorine-18, carbon-11 and gallium-68 using an array of printed point sources. For gallium-68, this required modification of the original design to handle its longer positron range. Using the fluorine-18 measurements and previously published data from Monte-Carlo simulations of positron range, estimated PSFs for carbon-11 and gallium-68 were calculated and compared with experimental data...
December 7, 2018: Physics in Medicine and Biology
István Hajdu, János Angyal, Dezső Szikra, István Kertész, Milo Malanga, Éva Fenyvesi, Lajos Szente, Miklós Vecsernyés, Ildikó Bácskay, Judit Váradi, Pálma Fehér, Zoltán Ujhelyi, Gábor Vasvári, Ágnes Rusznyák, György Trencsényi, Ferenc Fenyvesi
A new renaissance started in the research and application of cyclodextrins a few years ago. 2-Hydroxypropyl-beta-cyclodextrin (HPBCD) is used in the formulation of drugs and recently orphan designation was granted for the treatment of Niemann-Pick disease, type C. HPBCD is considered to be safe, but the exact mechanism of action and side effects are not completely explained. Labeled cyclodextrin derivatives are required to reveal the biological activity and in vivo distribution by imaging techniques. The aims of our study were to synthetize the 68 Ga-labeled NODAGA-hydroxypropyl-beta-cyclodextrin (68 Ga-NODAGA-HPBCD) and test the pharmacokinetic properties and in vivo distribution of this radiolabeled molecule...
December 3, 2018: European Journal of Pharmaceutical Sciences
Max Kiugel, Sanna Hellberg, Meeri Käkelä, Heidi Liljenbäck, Tiina Saanijoki, Xiang-Guo Li, Johanna Tuomela, Juhani Knuuti, Antti Saraste, Anne Roivainen
Background : The expression of matrix metalloproteinases 2/9 (MMP-2/9) has been implicated in arterial remodeling and inflammation in atherosclerosis. We evaluated a gallium-68 labeled peptide for the detection of MMP-2/9 in atherosclerotic mouse aorta. Methods : We studied sixteen low-density lipoprotein receptor deficient mice (LDLR-/- ApoB100/100 ) kept on a Western-type diet. Distribution of intravenously-injected MMP-2/9-targeting peptide, [68 Ga]Ga-DOTA-TCTP-1, was studied by combined positron emission tomography (PET) and contrast-enhanced computed tomography (CT)...
December 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Elin Pauwels, Frederik Cleeren, Guy Bormans, Christophe M Deroose
Somatostatin receptors (SSTRs) are variably expressed by a variety of malignancies. Using radiolabeled somatostatin analogs (SSAs), the presence of SSTRs on tumor cells may be exploited for molecular imaging and for peptide receptor radionuclide therapy. 111 In-DTPA-octreotide has long been the standard in SSTR scintigraphy. A major leap forward was the introduction of gallium-68 labeled SSAs for positron emission tomography (PET) offering improved sensitivity. Tracers currently in clinical use are 68 Ga-DOTA-Tyr3 -octreotide (68 Ga-DOTATOC), 68 Ga-DOTA-Tyr3 -octreotate (68 Ga-DOTATATE) and 68 Ga-DOTA-1-NaI3 -octreotide (68 Ga-DOTANOC), collectively referred to as 68 Ga-DOTA-peptides...
2018: American Journal of Nuclear Medicine and Molecular Imaging
I Al Jammaz, B Al-Otaibi, N Al-Hokbani, S M Okarvi
Myocardial perfusion imaging (MPI) is one of the most commonly performed investigations in nuclear medicine studies. Due to the physical properties of the positron emitter gallium-68 (68 Ga) and its availability from 68 Ge/68 Ga generator, together with the well-known coordination chemistry, we have synthesized 68 Ga-NOTA- and 68 Ga-NODAGA-rhodamine conjugates using a straightforward and a one-step simple reaction. Radiochemical yields were greater than 95% (decay corrected), with total synthesis time of less than 30 min...
September 8, 2018: Applied Radiation and Isotopes
Stefano Fanti, Silvia Minozzi, Gerald Antoch, Ian Banks, Alberto Briganti, Ignasi Carrio, Arturo Chiti, Noel Clarke, Matthias Eiber, Johann De Bono, Karim Fizazi, Silke Gillessen, Sam Gledhill, Uwe Haberkorn, Ken Herrmann, Rodney J Hicks, Frederic Lecouvet, Rodolfo Montironi, Piet Ost, Joe M O'Sullivan, Anwar R Padhani, Jack A Schalken, Howard I Scher, Bertrand Tombal, R Jeroen A van Moorselaar, Heindrik Van Poppel, Hebert Alberto Vargas, Jochen Walz, Wolfgang A Weber, Hans-Jürgen Wester, Wim J G Oyen
Rapid developments in imaging and treatment with radiopharmaceuticals targeting prostate cancer pose issues for the development of guidelines for their appropriate use. To tackle this problem, international experts representing medical oncologists, urologists, radiation oncologists, radiologists, and nuclear medicine specialists convened at the European Association of Nuclear Medicine Focus 1 meeting to deliver a balanced perspective on available data and clinical experience of imaging in prostate cancer, which had been supported by a systematic review of the literature and a modified Delphi process...
December 2018: Lancet Oncology
Sofiullah Olayinka Abubakar, Yaw Ampem Amoako, Naima Tag, Tessa Kotze
Imaging in prostate cancer is important in defining the local extent of disease, nodal involvement, and identifying metastases. Bone scan is the most commonly used modality for identification of bone metastasis in prostate cancer despite its reported low sensitivity and specificity compared to magnetic resonance imaging (MRI) which is the imaging gold standard for bone metastasis. Gallium-68 prostate-specific membrane antigen positron emission tomography-computed tomography (68 Ga PSMA PET-CT) imaging is a relatively new addition to the imaging modalities in prostate cancer...
October 2018: World Journal of Nuclear Medicine
M Wrzesień, Ł Albiniak
INTRODUCTION: Obtaining 68 Ga-DOTA-TATE (a radioconjugate consisting of the somatostatin analogue tyrosine-3-octreotate (Tyr3-octreotate or TATE) labelled with the positron emission tomography tracer gallium 68 Ga via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA)) is a complex process and, as with any radiopharmaceutical whose basis is a short-lived radionuclide generator, it is based on a sequence of procedures beginning from the 68 Ge/68 Ga generator elution, labelling ligands with a radioisotope, dispensing doses of 68 Ga-DOTA-TATE for patients and finally injection of the preparation to patients...
December 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
Marcin Czarniecki, Esther Mena, Liza Lindenberg, Marek Cacko, Stephanie Harmon, Jan Philipp Radtke, Frederick Giesel, Baris Turkbey, Peter L Choyke
Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is an emerging prostate cancer imaging method, which has been reported to have a higher sensitivity and specificity than the currently approved PET imaging agents. Multiple PSMA ligands are being investigated around the world and applications range from primary tumor characterization, to local staging, biochemical recurrence, metastasis, and image-guided interventions. The most investigated PET tracers are labelled with 68-Gallium or 18-Fluoride and are discussed in this review...
October 2018: Translational Andrology and Urology
Anais Moyon, Philippe Garrigue, Laure Balasse, Samantha Fernandez, Pauline Brige, Marie Nollet, Guillaume Hache, Marcel Blot-Chabaud, Françoise Dignat-George, Benjamin Guillet
This study aimed to develop a PET imaging agent of angiomotin (AMOT) expression, a potential biomarker of functional tissue regeneration in post-ischaemic conditions. Methods: Hindlimb ischaemia was induced by ligature and resection of the right femoral artery in mice, and clinical score and limb perfusion were evaluated up to 30 days after surgery. AMOT expression was evaluated by histology and Western blot analysis. NODAGA-conjugates of AMOT ligand, sCD146, were designed, synthesised and radiolabelled with gallium-68...
2018: Theranostics
John F Tierney, Cory Kosche, Erik Schadde, Amjad Ali, Sumeet Virmani, Sam G Pappas, Jennifer Poirier, Xavier M Keutgen
BACKGROUND: 68 Gallium-DOTATATE positron emission tomography-computed tomography (PET CT) has shown superior accuracy in detecting grade 1 and 2 neuroendocrine tumors over previous imaging modalities and was recently included in National Comprehensive Cancer Network guidelines. It remains unclear which patients benefit most from this imaging modality. We therefore reviewed our initial experience with 68 Gallium-DOTATATE PET CT to evaluate its usefulness in diagnosing, staging, and surveilling neuroendocrine tumors...
November 8, 2018: Surgery
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