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https://www.readbyqxmd.com/read/27906978/correction-of-rings-and-rods-regulating-cohesin-entrapment-of-dna-to-generate-intra-and-intermolecular-tethers
#1
Robert V Skibbens
[This corrects the article DOI: 10.1371/journal.pgen.1006337.].
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27872183/roles-of-the-essential-protein-ftsa-in-cell-growth-and-division-in-streptococcus-pneumoniae
#2
Andrea Mura, Daniela Fadda, Amilcar J Perez, Madeline L Danforth, Daniela Musu, Ana Isabel Rico, Marcin Krupka, Dalia Denapaite, Ho-Ching T Tsui, Malcolm E Winkler, Pavel Branny, Miguel Vicente, William Margolin, Orietta Massidda
: Streptococcus pneumoniae is an ovoid-shaped Gram-positive bacterium that grows by carrying out peripheral and septal peptidoglycan (PG) synthesis, analogous to model bacilli such as Escherichia coli and Bacillus subtilis In the model bacilli, FtsZ and FtsA proteins assemble into a ring at midcell and are dedicated to septal PG synthesis, but not peripheral PG synthesis; hence inactivation of FtsZ or FtsA results in long filamentous cells unable to divide. Here we demonstrate that FtsA and FtsZ colocalize at midcell in S...
November 21, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27866940/anterior-pre-tensioned-external-fixator-for-pelvic-fractures-and-dislocations-initial-clinical-series
#3
A Queipo-de-Llano, M Lombardo-Torre, A Leiva-Gea, F B Delgado-Rufino, F Luna-González
In the treatment of unstable pelvic ring fractures, external fixators have the limitation of not adequately stabilizing the injured posterior elements. This article presents a novel and simple technique of temporary external fixation of the pelvic ring, able to produce compression of both the anterior and posterior pelvic elements. A curved flexible carbon-fiber rod is used, pre-tensioned before attachment to supra-acetabular Schanz screws. Although more extensive clinical experience is required, favorable preliminary results in a series of 13 patients with unstable pelvic fracture were encouraging: the aim of closing the posterior and anterior elements of the pelvic ring was achieved in all cases treated with this technique, and 12 patients survived...
November 17, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27844412/anti-rods-rings-autoantibody-seropositivity-does-not-affect-response-to-telaprevir-treatment-for-chronic-hepatitis-c-infection
#4
S John Calise, Nicola Bizzaro, Thuy Nguyen, Danila Bassetti, Brunetta Porcelli, Paolo Almi, Giuseppina Barberio, Giampaola Pesce, Minoru Satoh, Edward K L Chan
PURPOSE: Autoantibodies to intracellular 'rods and rings' structures (anti-rods/rings or anti-RR) are strongly associated with hepatitis C (HCV) patients treated with interferon-α/ribavirin (IFN/RBV) and are linked with non-responsiveness to IFN/RBV or relapse, especially in Italian patients. This is the first study to determine whether there is any correlation of anti-RR with non-responsiveness to IFN/RBV treatment in patients also treated with telaprevir (TPV), one of several new therapies for chronic HCV recently implemented...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27825365/a-prospective-case-series-for-a-minimally-invasive-internal-fixation-device-for-anterior-pelvic-ring-fractures
#5
Wayne Hoskins, Andrew Bucknill, James Wong, Edward Britton, Rodney Judson, Kellie Gumm, Roselyn Santos, Rohan Sheehy, Xavier Griffin
BACKGROUND: External fixation is commonly used as a means of definitive fixation of pelvic fractures. Pin site infection is common, with some cases of osteomyelitis and inpatient nursing can be challenging. The aim of this study is to report the outcomes and complications of an alternative minimally invasive technique, known as INFIX, utilising spinal pedicle screws inserted into the supra-acetabular bone and connected by a subcutaneous rod. METHODS: A single-centre prospective case series was performed...
November 8, 2016: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/27822341/model-acupuncture-point-bone-marrow-derived-stromal-stem-cells-are-moved-by-a-weak-electromagnetic-field
#6
Artem N Emelyanov, Marina V Borisova, Vera V Kiryanova
AIM: To show the existence of a structural formative role of magnetic fields (MFs) with respect to biological objects by using our proposed model of an acupoint. METHODS: We introduced a magnetised 10-100 μT metal rod (needle) into culture dishes with a negatively charged working surface and observed during 24 h how cells were arranged by MFs and by electrical fields (EFs) when attached. Rat and human bone marrow-derived stromal stem cells (rBMSCs and hBMSCs), human nonadherent mononuclear blood cells, NCTCs and A172 cells, and Escherichia coli (E...
October 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/27818950/type-three-secretion-system-in-attaching-and-effacing-pathogens
#7
REVIEW
Meztlli O Gaytán, Verónica I Martínez-Santos, Eduardo Soto, Bertha González-Pedrajo
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes, together with the mouse pathogen Citrobacter rodentium, belong to the family of attaching and effacing pathogens that form a distinctive histological lesion in the intestinal epithelium. The virulence of these bacteria depends on a type III secretion system (T3SS), which mediates the translocation of effector proteins from the bacterial cytosol into the infected cells...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27803076/mutational-analysis-and-overproduction-effects-of-motx-an-essential-component-for-motor-function-of-na-driven-polar-flagella-of-vibrio
#8
Norihiro Takekawa, Seiji Kojima, Michio Homma
The bacterial flagellar motor is a rotary motor complex composed of various proteins. The motor contains a central rod, multiple ring-like structures and stators. The Na(+)-driven polar flagellar motor of the marine bacterium Vibrio alginolyticus has a specific ring, called the 'T-ring', which consists of two periplasmic proteins, MotX and MotY. The T-ring is essential for assembly of the torque-generating unit, the PomA/PomB stator complex, into the motor. To investigate the role of the T-ring for motor function, we performed random mutagenesis of the motX gene on a plasmid...
October 25, 2016: Journal of Biochemistry
https://www.readbyqxmd.com/read/27798680/loukoumasomes-are-distinct-subcellular-structures-from-rods-and-rings-and-are-structurally-associated-with-map2-and-the-nuclear-envelope-in-retinal-cells
#9
Jake W Noble, Diana V Hunter, Calvin D Roskelley, Edward K L Chan, Julia Mills
"Rods and rings" (RR) and loukoumasomes are similarly shaped, subcellular macromolecular structures with as yet unknown function. RR, so named because of their shape, are formed in response to inhibition in the GTP or CTP synthetic pathways and are highly enriched in the two key enzymes of the nucleotide synthetic pathway. Loukoumasomes also occur as linear and toroidal bodies and were initially inferred to be the same as RR, largely due to their shared shape and size and the fact that it was unclear if they shared the same subcomponents...
2016: PloS One
https://www.readbyqxmd.com/read/27788133/of-rings-and-rods-regulating-cohesin-entrapment-of-dna-to-generate-intra-and-intermolecular-tethers
#10
REVIEW
Robert V Skibbens
The clinical relevance of cohesin in DNA repair, tumorigenesis, and severe birth defects continues to fuel efforts in understanding cohesin structure, regulation, and enzymology. Early models depicting huge cohesin rings that entrap two DNA segments within a single lumen are fading into obscurity based on contradictory findings, but elucidating cohesin structure amid a myriad of functions remains challenging. Due in large part to integrated uses of a wide range of methodologies, recent advances are beginning to cast light into the depths that previously cloaked cohesin structure...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27755822/%C3%AF-extended-star-shaped-polycyclic-aromatic-hydrocarbons-based-on-fused-truxenes-synthesis-self-assembly-and-facilely-tunable-emission-properties
#11
Cheng Cheng, Yi Jiang, Cheng-Fang Liu, Jian-Dong Zhang, Wen-Yong Lai, Wei Huang
A new set of star-shaped polycyclic aromatic hydrocarbons (PAHs) based on naphthalene-fused truxenes, TrNaCn (n=1-4), were synthesized and characterized. The synthesis involved a microwave-assisted six-fold Suzuki coupling reaction, followed by oxidative cyclodehydrogenation. Multiple dehydrocyclization products could be effectively isolated in a single reaction, thus suggesting that the oxidative cyclodehydrogenation reaction involved a stepwise ring-closing process. The thermal, optical, and electrochemical properties and the self-assembly behavior of the resulting oxidized samples were investigated to understand the impact of the ring-fusing process on the properties of the star-shaped PAHs...
October 18, 2016: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/27753486/aggregation-dispersion-transition-for-nanoparticles-in-semiflexible-ring-polymer-nanocomposite-melts
#12
Zhenyu Deng, Yangwei Jiang, Linli He, Linxi Zhang
By employing molecular dynamics simulations, we explored the conformation transition of nanoparticles (NPs) in semiflexible ring polymer nanocomposite melts. A novel aggregation- dispersion transition for NPs in ring polymer nanocomposites occurs when the bending energy of ring chains increases. The conformations of flexible ring chains near NPs are radial distribution, and the entropic depletion interactions between a pair of NPs in flexible ring polymer nanocomposite melts are attractive, however, the rod-like ring chains are wrapped around the NPs and the entropic depletion interactions between NPs in rod-like ring polymer melts are repulsive...
October 18, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27748355/treatment-of-unstable-posterior-pelvic-ring-fracture-with-pedicle-screw-rod-fixator-versus-locking-compression-plate-a-comparative-study
#13
Chun Bi, Qiugen Wang, Christopher Nagelli, Jianhong Wu, Qian Wang, Jiandong Wang
BACKGROUND The aim of this study was to assess the clinical results of treatment for unstable posterior pelvic fractures using a pedicle screw-rod fixator compared to use of a locking compression plate. MATERIAL AND METHODS A retrospective study was performed between June 2010 and May 2014 and the data were collected from 46 patients with unstable posterior pelvic ring fractures. All patients were treated using either a pedicle screw-rod fixator (study group, 24 patients) or locking compression plate (control group, 22 patients)...
October 17, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27746381/differential-capacity-of-therapeutic-drugs-to-induce-rods-rings-structures-in-vitro-and-in-vivo-and-generation-of-anti-rods-rings-autoantibodies
#14
Gerson Dierley Keppeke, Monica Simon Prado, Eunice Nunes, Sandro Felix Perazzio, Silvia Helena Rodrigues, Maria Lucia Gomes Ferraz, Edward K L Chan, Luis Eduardo Coelho Andrade
Some HCV patients using ribavirin and interferon alpha (IFN-α) develop anti-rods and rings (RR) autoantibodies, the main target of which is inosine monophosphate dehydrogenase (IMPDH), the rate-determining enzyme in de novo GTP biosynthesis. In vitro inhibition of IMPDH by ribavirin induces RR formation. Here we investigate whether other commonly used drugs that interfere with GTP biosynthesis can induce RR structures in vitro and vivo and elicit generation of autoantibodies. HEp-2 cells treated for 24h with ribavirin, mycophenolic acid (MPA), azathioprine, methotrexate or acyclovir were positive for RR structures...
October 13, 2016: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/27723729/asynchronous-division-by-non-ring-ftsz-in-the-gammaproteobacterial-symbiont-of-robbea-hypermnestra
#15
Nikolaus Leisch, Nika Pende, Philipp M Weber, Harald R Gruber-Vodicka, Jolanda Verheul, Norbert O E Vischer, Sophie S Abby, Benedikt Geier, Tanneke den Blaauwen, Silvia Bulgheresi
The reproduction mode of uncultivable microorganisms deserves investigation as it can largely diverge from conventional transverse binary fission. Here, we show that the rod-shaped gammaproteobacterium thriving on the surface of the Robbea hypermnestra nematode divides by FtsZ-based, non-synchronous invagination of its poles-that is, the host-attached and fimbriae-rich pole invaginates earlier than the distal one. We conclude that, in a naturally occurring animal symbiont, binary fission is host-oriented and does not require native FtsZ to polymerize into a ring at any septation stage...
October 10, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27716018/less-invasive-lumbopelvic-fixation-technique-using-a-percutaneous-pedicle-screw-system-for-unstable-pelvic-ring-fracture-in-a-patient-with-severe-multiple-traumas
#16
Sei Yano, Yasuchika Aoki, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa, Hiroyuki Hirasawa, Kazuhisa Takahashi, Koichi Nakagawa, Arata Nakajima, Hiroshi Takahashi, Sumihisa Orita, Yawara Eguchi, Takane Suzuki, Seiji Ohtori
Pelvic ring fractures are defined as life-threatening injuries that can be treated surgically with external or internal fixation. The authors report on an 81-year-old woman with an unstable pelvic fracture accompanying multiple traumas that was successfully treated with a less invasive procedure. The patient was injured in a traffic accident and sustained a total of 20 fractures, including pelvic ring, bilateral rib, and lumbar transverse processes fractures, and multiple fractures of both upper and lower extremities...
October 7, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27715092/pointlike-inclusion-interactions-in-tubular-membranes
#17
Afshin Vahid, Timon Idema
Membrane tubes and tubular networks are ubiquitous in living cells. Inclusions like proteins are vital for both the stability and the dynamics of such networks. These inclusions interact via the curvature deformations they impose on the membrane. We analytically study the resulting membrane mediated interactions in strongly curved tubular membranes. We model inclusions as constraints coupled to the curvature tensor of the membrane tube. First, as special test cases, we analyze the interaction between ring- and rod-shaped inclusions...
September 23, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27698177/intramedullary-nailing-and-external-ring-fixation-for-tibiotalocalcaneal-arthrodesis-in-charcot-arthropathy
#18
James Richman, Adam Cota, Steven Weinfeld
BACKGROUND: Surgical strategies to address deformities of the ankle and hindfoot in patients with Charcot arthropathy include the use of retrograde intramedullary nails and ring fixators. The literature has not shown superiority of one technique over the other. This study presents a single surgeon's case series of Charcot arthropathy patients treated with either a ring fixator or retrograde intramedullary nail to achieve tibiotalocalcaneal arthrodesis. METHODS: We performed a retrospective analysis of 27 consecutive patients with Charcot arthropathy who underwent a tibiotalocalcaneal arthrodesis using either a retrograde intramedullary (IM) nail (n = 16 patients) or a ring fixator (RF) (n = 11 patients) by a single surgeon...
October 2, 2016: Foot & Ankle International
https://www.readbyqxmd.com/read/27647891/rotation-of-artificial-rotor-axles-in-rotary-molecular-motors
#19
Mihori Baba, Kousuke Iwamoto, Ryota Iino, Hiroshi Ueno, Mayu Hara, Atsuko Nakanishi, Jun-Ichi Kishikawa, Hiroyuki Noji, Ken Yokoyama
F1- and V1-ATPase are rotary molecular motors that convert chemical energy released upon ATP hydrolysis into torque to rotate a central rotor axle against the surrounding catalytic stator cylinder with high efficiency. How conformational change occurring in the stator is coupled to the rotary motion of the axle is the key unknown in the mechanism of rotary motors. Here, we generated chimeric motor proteins by inserting an exogenous rod protein, FliJ, into the stator ring of F1 or of V1 and tested the rotation properties of these chimeric motors...
October 4, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27638456/colloidal-aggregation-and-structural-assembly-of-aspect-ratio-variant-goethite-%C3%AE-feooh-with-nc60-fullerene-in-environmental-media
#20
Saikat Ghosh, Nihar R Pradhan, Hamid Mashayekhi, Qiu Zhang, Bo Pan, Baoshan Xing
Environmental mobility of C60 fullerene can be significantly affected in the presence of naturally abundant α-FeOOH. However, α-FeOOH vary significantly in sizes, shapes and associated properties that can greatly influence the fate and transport of C60 fullerene in environmental media. Therefore, colloidal hetero-association between well crystallized low aspect (LAsp) α-FeOOH and nC60 fullerene may differ substantially to weakly crystallized high-aspect (HAsp) counterpart. In contrast to LAsp α-FeOOH, inherent crystal defects and surface charge generation in HAsp α-FeOOH facilitated strong Coulombic attraction and aggregation with fullerene in acidic pH...
September 13, 2016: Environmental Pollution
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