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https://www.readbyqxmd.com/read/29453250/retinal-chitosan-conjugates-effectively-deliver-active-chromophores-to-retinal-photoreceptor-cells-in-blind-mice-and-dogs
#1
Songqi Gao, Shirin Kahremany, Jianye Zhang, Beata Jastrzebska, Janice Querubin, Simon M Petersen-Jones, Krzysztof Palczewski
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the visual chromophore, 11-cis-retinal and sustain vision. Genetic or environmental factors affecting chromophore production can lead to blindness. Using animal models that mimic human retinal diseases, we previously demonstrated that mechanism-based pharmacological interventions can maintain vision in otherwise incurable genetic diseases of the retina. Here, we report that after 9-cis-retinal administration to lecithin:retinol acyltransferase-deficient (Lrat-/-) mice, the drug was rapidly absorbed and then cleared within 1-2 h...
February 16, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29443967/peptidoglycan-synthesis-drives-an-ftsz-treadmilling-independent-step-of-cytokinesis
#2
João M Monteiro, Ana R Pereira, Nathalie T Reichmann, Bruno M Saraiva, Pedro B Fernandes, Helena Veiga, Andreia C Tavares, Margarida Santos, Maria T Ferreira, Vânia Macário, Michael S VanNieuwenhze, Sérgio R Filipe, Mariana G Pinho
Peptidoglycan is the main component of the bacterial wall and protects cells from the mechanical stress that results from high intracellular turgor. Peptidoglycan biosynthesis is very similar in all bacteria; bacterial shapes are therefore mainly determined by the spatial and temporal regulation of peptidoglycan synthesis rather than by the chemical composition of peptidoglycan. The form of rod-shaped bacteria, such as Bacillus subtilis or Escherichia coli, is generated by the action of two peptidoglycan synthesis machineries that act at the septum and at the lateral wall in processes coordinated by the cytoskeletal proteins FtsZ and MreB, respectively...
February 14, 2018: Nature
https://www.readbyqxmd.com/read/29429654/ultrasonic-assisted-synthesis-and-the-structural-characterization-of-novel-the-zig-zag-cd-ii-metal-organic-polymer-and-their-nanostructures
#3
Faeze Mojtabazade, Babak Mirtamizdoust, Ali Morsali, Pejman Talemi
A sonochemical method was used to synthesize nano-rods of a novel cadmium(II) metal-organic coordination polymer, [Cd(p-2yeinh)(NO2)]n (1) (p-2yeinh = pyridin-2-yl ethylidene-isonicotinohydrazide). The effect of the synthesis parameters such as time, concentrations and irradiation power has been studied and optimized. It was shown that the thickness of rods has changed from 27 nm to 45 nm. The compounds were characterized by scanning electron microscopy (SEM), elemental analysis, IR spectroscopy, X-ray powder diffraction (XPRD), and single crystal X-ray analysis...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29424530/helical-rod-like-phenylene-cages-via-ruthenium-catalyzed-diol-diene-benzannulation-a-cord-of-three-strands
#4
Hiroki Sato, Jon A Bender, Sean T Roberts, Michael J Krische
p-Bromo-terminated oligo(p-phenylenevinylenes) emanating from a 1,3,5-benzene core are dihydroxylated and subjected to ruthenium catalyzed diol-diene benzannulation to form tripodal oligo(phenylenes). Copper- or nickel-mediated 3-fold reductive biaryl homocoupling delivers a series of triple-stranded phenylene cages of helical rod-like topology bearing 14, 17, and 20 benzene rings.
February 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29422517/role-of-precursor-carbides-for-graphene-growth-on-ni-111
#5
Raffael Rameshan, Vedran Vonk, Dirk Franz, Jakub Drnec, Simon Penner, Andreas Garhofer, Florian Mittendorfer, Andreas Stierle, Bernhard Klötzer
Surface X-ray Diffraction was used to study the transformation of a carbon-supersaturated carbidic precursor toward a complete single layer of graphene in the temperature region below 703 K without carbon supply from the gas phase. The excess carbon beyond the 0.45  monolayers of C atoms within a single Ni2C layer is accompanied by sharpened reflections of the |4772| superstructure, along with ring-like diffraction features resulting from non-coincidence rotated Ni2C-type domains. A dynamic Ni2C reordering process, accompanied by slow carbon loss to subsurface regions, is proposed to increase the Ni2C 2D carbide long-range order via ripening toward coherent domains, and to increase the local supersaturation of near-surface dissolved carbon required for spontaneous graphene nucleation and growth...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29408597/clostridial-diviva-and-mind-interact-in-the-absence-of-minj
#6
Romana Valenčíková, Eva Krascsenitsová, Naďa Labajová, Jana Makroczyová, Imrich Barák
One of the key regulators ensuring proper Z-ring placement in rod-shaped bacteria is the Min system. It does so by creating a concentration gradient of the MinC septation inhibitor along the cell axis. In Escherichia coli, this gradient is established by a MinE-mediated pole-to-pole oscillation of the MinCDE complex. In Bacillus subtilis, the creation of an inhibitory gradient relies on the MinJ and DivIVA pair of topological determinants, which target MinCD to the newly formed cell poles. Introducing the E...
January 30, 2018: Anaerobe
https://www.readbyqxmd.com/read/29386879/full-field-erg-as-a-predictor-of-the-natural-course-of-abca4-associated-retinal-degenerations
#7
Marion Schroeder, Ulrika Kjellström
Purpose: To assess retinal function in combination with the retinal structure in ABCA4-associated retinal degenerations. Moreover, to evaluate the possibility of predicting the natural course of these disorders. Methods: 34 patients with Stargardt disease or cone rod dystrophy carrying confirmed mutations in ABCA4 were selected from our retinitis pigmentosa (RP) register. Sequence analysis of the entire coding region of the ABCA4 gene was performed. The patients were subdivided into three groups based on their most recent visual fields...
2018: Molecular Vision
https://www.readbyqxmd.com/read/29352994/topical-drug-delivery-devices-a-review
#8
REVIEW
C J F Bertens, M Gijs, R M M A Nuijts, F J H M van den Biggelaar
For the treatment and prevention of ocular diseases, most patients are treated with conventional drug delivery formulations such as eye drops or ointments. However, eye drops and ointments suffer from low patient compliance and low effective drug concentration at the target site. Therefore, new medical devices are being explored to improve drug delivery to the eye. Over the years, various delivery devices have been developed including resorbable devices, oval- and ring-shaped devices, rod-shaped devices, punctum plugs, contact lenses and corneal shields...
January 15, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29349841/novel-mof-derived-co-n-c-bifunctional-catalysts-for-highly-efficient-zn-air-batteries-and-water-splitting
#9
Mingdao Zhang, Quanbin Dai, Hegen Zheng, Mindong Chen, Liming Dai
Metal-organic frameworks (MOFs) and MOF-derived materials have recently attracted considerable interest as alternatives to noble-metal electrocatalysts. Herein, the rational design and synthesis of a new class of Co@N-C materials (C-MOF-C2-T) from a pair of enantiotopic chiral 3D MOFs by pyrolysis at temperature T is reported. The newly developed C-MOF-C2-900 with a unique 3D hierarchical rodlike structure, consisting of homogeneously distributed cobalt nanoparticles encapsulated by partially graphitized N-doped carbon rings along the rod length, exhibits higher electrocatalytic activities for oxygen reduction and oxygen evolution reactions (ORR and OER) than that of commercial Pt/C and RuO2 , respectively...
January 19, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29349462/self-assembly-of-bis-salphen-compounds-from-semiflexible-chains-to-webs-of-nanorings
#10
Sergey V Pyrlin, Nicholas D M Hine, Arjan W Kleij, Marta M D Ramos
The recently-observed self-assembly of certain salphen-based compounds into neuron-like networks of microrings interconnected with nano-thin strings may suggest a new highly-potent tool for nanoscale patterning. However, the mechanism behind such phenomena needs to be clarified before they can be applied in materials design. Here we show that, in contrast with what was initially presumed, the emergence of a "rings-and-rods" pattern is unlikely to be explained by merging, collapse and piercing of vesicles as in previously reported cases of nanorings self-assembly via non-bonding interactions...
January 19, 2018: Soft Matter
https://www.readbyqxmd.com/read/29322211/-within-ring-based-sacroiliac-rod-fixation-may-overcome-the-weakness-of-spinopelvic-fixation-for-unstable-pelvic-ring-injuries-technical-notes-and-clinical-outcomes
#11
Kentaro Futamura, Tomonori Baba, Atsuhiko Mogami, Akio Kanda, Osamu Obayashi, Hideaki Iwase, Kazuo Kaneko
PURPOSE: Spinopelvic fixation and triangular osteosynthesis give firm internal fixation for unstable pelvic ring injuries (UPRI), but with sacrifice of mobility of the lumbar spine. Here, we describe the procedure and outcomes of a new approach, which we refer to as "within ring"-based sacroiliac rod fixation (SIRF). METHODS: The patient was placed in a prone position and longitudinal skin incisions were made at the medial margins of the bilateral posterior superior iliac spines (PSIS)...
January 10, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29310362/wrapping-grafting-for-congenital-pseudarthrosis-of-the-tibia-a-preliminary-report
#12
An Yan, Hai-Bo Mei, Kun Liu, Jiang-Yan Wu, Jin Tang, Guang-Hui Zhu, Wei-Hua Ye
OBJECTIVE: Treatment of congenital pseudarthrosis of the tibia (CPT) remains a challenge. The autogenic iliac bone graft is important consistent of treatment for CPT. The purpose of this study was to investigate the role of wrapping autogenic iliac bone graft in improvement of the curing opportunities of CPT. METHODS: We combined Ilizarov fixator with intramedullary rodding of the tibia and wrapping autogenic iliac bone graft for treatment 51 cases of CPT between 2007 and 2010...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29307021/cerebellar-infarction-after-posterior-direct-reduction-and-fixation-to-treat-an-unstable-jefferson-fracture-a-case-report
#13
Seung Hwan Baek, Seung Ho Yoo, Kyoung Rai Cho, Jun Jae Shin
A 42-year-old man had an unstable Jefferson type IV atlas fracture with unilateral vertebral artery occlusion after a diving accident. We performed C1-ring reconstruction with a crosslink rod and C2 fixation to directly reduce the fracture fissure. Within 6 h, cerebellar hemisphere infarction developed. After decompressive craniectomy, duroplasty, and release of the vertebral artery occlusion caused by the transfixing rod, a postoperative computed tomography angiogram showed that blood flow in the right vertebral artery improved...
January 6, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29287273/disruption-of-actin-filaments-in-zea-mays-by-bisphenol-a-depends-on-their-crosstalk-with-microtubules
#14
Konstantina Stavropoulou, Ioannis-Dimosthenis S Adamakis, Emmanuel Panteris, Ermioni-Makedonia Arseni, Eleftherios P Eleftheriou
Bisphenol A (BPA) is a widespread environmental pollutant, reportedly harmful to living organisms. In plant cells, BPA was shown to disrupt microtubule (MT) arrays and perturb mitosis, but its effects on filamentous actin (F-actin) have not been explored. Here we studied the effects of BPA on actin filaments (AFs) in meristematic root tip and leaf cells of Zea mays, by fluorescent labeling and confocal microscopy. Considering the typical dynamic interaction between MTs and AFs, the effects on these two essential components of the plant cytoskeleton were correlated...
December 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29279323/the-hidden-genomic-and-transcriptomic-plasticity-of-giant-marker-chromosomes-in-cancer
#15
Gemma Macchia, Marco Severgnini, Stefania Purgato, Doron Tolomeo, Hilen Casciaro, Ingrid Cifola, Alberto L'Abbate, Anna Loverro, Orazio Palumbo, Massimo Carella, Laurence Bianchini, Giovanni Perini, Gianluca De Bellis, Fredrik Mertens, Mariano Rocchi, Clelia T Storlazzi
Genome amplification in the form of rings or giant rod-shaped marker chromosomes is a common genetic alteration in soft tissue tumours. The mitotic stability of these structures is often rescued by perfectly functioning analphoid neocentromeres, which therefore significantly contribute to cancer progression. Here, we disentangled the genomic architecture of many neocentromeres stabilizing marker chromosomes in well-differentiated liposarcoma and lung sarcomatoid carcinoma samples. In cells carrying heavily rearranged RGMs, these structures were assembled as patchworks of multiple short amplified sequences, disclosing an extremely high level of complexity and definitely ruling out the existence of regions prone to the neocentromere seeding...
December 26, 2017: Genetics
https://www.readbyqxmd.com/read/29273093/patient-related-outcome-of-unstable-pelvic-ring-fractures-stabilized-with-a-minimal-invasive-screw-rod-system
#16
Maximilian Kerschbaum, Nadine Hausmann, Michael Worlicek, Christian Pfeifer, Michael Nerlich, Paul Schmitz
BACKGROUND: Clinical and radiological outcomes of operatively treated unstable pelvic ring fractures are well documented, whereas little is known about the patient's related outcome. The purpose of this study is to evaluate the patient-reported outcome after minimal invasive treatment of pelvic ring fractures using the SF-36 and EQ-5D medical outcome scores. METHODS: Patients with unstable pelvic ring fractures treated in our trauma department with a minimal invasive screw-rod system between 01/2004 and 12/2014 were included...
December 22, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29247322/a-biomechanical-study-of-sacroiliac-rod-fixation-for-unstable-pelvic-ring-injuries-verification-of-the-within-ring-concept
#17
Kentaro Futamura, Tomonori Baba, Atsuhiko Mogami, Itaru Morohashi, Osamu Obayashi, Hideaki Iwase, Kazuo Kaneko
PURPOSE: The aim of this study was to compare the fixation power of sacroiliac rod fixation (SIRF), which was developed based on our original "within ring" concept to exclude the lumbar vertebra from the fixation range, and spinopelvic fixation (SPF) in a biomechanical experiment. METHODS: SPF and SIRF were applied to the posterior element in four bones each with the pelvic ring fracture model (AO/OTA classification 61-C1.3). A 300-N axial force was loaded on the fifth lumbar vertebra of the simulated pelvis...
December 15, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29238871/minimally-invasive-stabilisation-of-posterior-pelvic-ring-instabilities-with-pedicle-screws-connected-to-a-transverse-rod
#18
Hu Wang, Ya-Hui Fu, Chao Ke, Yan Zhuang, Kun Zhang, Xing Wei, Zhong Li, Jin-Lai Lei, Bin-Fei Zhang, Ping Liu
PURPOSE: The goal was to evaluate the clinical outcomes, quality of reduction and complications of pelvic fractures treated by minimally invasive stabilisation of posterior pelvic ring instabilities with pedicle screws connected to a transverse rod. METHODS: Retrospective analysis of prospectively collected data in a consecutive patient series with pelvic fractures treated by minimally invasive stabilisation of posterior pelvic ring instabilities with pedicle screws between January 2010 and January 2016...
December 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29216149/on-chip-wavelength-locking-for-photonic-switches
#19
Akhilesh S P Khope, Takako Hirokawa, Andrew M Netherton, Mitra Saeidi, Yujie Xia, Nicolas Volet, Clint Schow, Roger Helkey, Luke Theogarajan, Adel A M Saleh, John E Bowers, Rod C Alferness
We present an on-chip wavelength reference with a partial drop ring resonator and germanium photodetector. This approach can be used in ring-resonator-based wavelength-selective switches where absolute wavelength alignment is required. We use the temperature dependence of heater resistance as a temperature sensor. Additionally, we discuss locking speed, statistical variation of heater resistances, and tuning speed of the switches.
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29205883/fission-yeast-myo2-molecular-organization-and-diffusion-in-the-cytoplasm
#20
Janice E Friend, Wasim A Sayyad, Rajesh Arasada, Chad D McCormick, John E Heuser, Thomas D Pollard
Myosin-II is required for the assembly and constriction of cytokinetic contractile rings in fungi and animals. We used electron microscopy, fluorescence recovery after photobleaching (FRAP), and fluorescence correlation spectroscopy (FCS) to characterize the physical properties of Myo2 from fission yeast Schizosaccharomyces pombe. By electron microscopy, Myo2 has two heads and a coiled-coiled tail like myosin-II from other species. The first 65 nm of the tail is a stiff rod, followed by a flexible, less-ordered region up to 30 nm long...
December 4, 2017: Cytoskeleton
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