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https://www.readbyqxmd.com/read/28327156/mycobacterium-goodii-endocarditis-following-mitral-valve-ring-annuloplasty
#1
Rohan B Parikh, Matthew Grant
BACKGROUND: Mycobacterium goodii is an infrequent human pathogen which has been implicated in prosthesis related infections and penetrating injuries. It is often initially misidentified as a gram-positive rod by clinical microbiologic laboratories and should be considered in the differential diagnosis. CASE PRESENTATION: We describe here the second reported case of M. goodii endocarditis. Species level identification was performed by 16S rDNA (ribosomal deoxyribonucleic acid) gene sequencing...
March 21, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28272311/synthesis-and-biological-activities-of-ethyl-2-2-pyridylacetate-derivatives-containing-thiourea-1-2-4-triazole-thiadiazole-and-oxadiazole-moieties
#2
Daniel Szulczyk, Piotr Tomaszewski, Michał Jóźwiak, Anna E Kozioł, Tadeusz Lis, David Collu, Filippo Iuliano, Marta Struga
Thirty six novel heterocyclic derivatives of ethyl 2-(2-pyridylacetate) were efficiently synthesized. The new compounds involve the linkage of a 2-pyridyl ring with thiosemicarbazide (compounds 1-7), 1,2,4-triazole (compounds 1a-7a), 1,3,4-thiadiazole (compounds 1b-7b), and 1,3,4-oxadiazole (compounds 1f-7f) moieties. The last group of compounds 1e-7e involves the connection of a 2-pyridyl ring with 1,2,4-triazole and thiourea. ¹H-NMR, (13)C-NMR and MS methods were used to confirm the structures of the obtained derivatives...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28270223/biomechanical-characteristics-of-fixation-methods-for-floating-pubic-symphysis
#3
Wenhao Song, Dongsheng Zhou, Yu He
BACKGROUND: Floating pubic symphysis (FPS) is a relatively rare injury caused by high-energy mechanisms. There are several fixation methods used to treat FPS, including external fixation, subcutaneous fixation, internal fixation, and percutaneous cannulated screw fixation. To choose the appropriate fixation, it is necessary to study the biomechanical performance of these different methods. The goal of this study was to compare the biomechanical characteristics of six methods by finite element analysis...
March 7, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28236073/complications-after-percutaneous-internal-fixator-for-anterior-pelvic-ring-injuries
#4
Christian Fang, Hatem Alabdulrahman, Hans-Christophe Pape
OBJECTIVES: The aim of the study is to report on the observed incidence of complications following pedicle screw and rod internal fixator (INFIX) stabilization of pelvic ring fractures. METHODS: In a retrospective review of consecutive patient series conducted in a University level 1 trauma hospital, 43 patients (21 female and eight male), mean age 64.2 (range 16-87) with OTA/AO type B or C pelvic ring fractures received percutaneous pedicle screw and rod internal fixator (INFIX) anterior stabilization of pelvic ring fractures; 29 fulfilled inclusion criteria with three months' minimal follow-up or known complication...
February 24, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28217344/crystal-structure-of-catena-poly-bis-acetato-%C3%AE%C2%BAo-copper-ii-bis-%C3%AE-4-1h-imidazol-1-yl-phenol-%C3%AE%C2%BA-2-n-3-o-%C3%AE%C2%BA-2-o-n-3
#5
Mehmet Poyraz, Musa Sarı
In the title compound, [Cu(CH3COO)2(C9H8N2O)2] n , the Cu(II) ion resides on a centre of inversion, displaying a tetra-gonally distorted octa-hedral coordination environment defined by two pairs of N and O atoms of symmetry-related 4-(1H-imidazol-1-yl)phenol ligands and the O atoms of two symmetry-related acetate ligands. The bridging mode of the 4-(1H-imidazol-1-yl)phenol ligands is associated with a very long Cu⋯O inter-actions involving the phenol O atom of the heterocyclic ligand, which creates chains extending parallel to [100]...
February 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28196868/an-interaction-between-the-inner-rod-protein-ysci-and-the-needle-protein-yscf-is-required-to-assemble-the-needle-structure-of-the-yersinia-type-three-secretion-system
#6
Shi-Yang Cao, Wan-Bin Liu, Ya-Fang Tan, Hui-Ying Yang, Ting-Ting Zhang, Tong Wang, Xiao-Yi Wang, Ya-Jun Song, Rui-Fu Yang, Zong-Min Du
The type III secretion system is a highly conserved virulence mechanism that is widely distributed in Gram-negative bacteria. It has a syringe-like structure composed of a multi-ring basal body that spans the bacterial envelope, and a projecting needle that delivers virulence effectors into host cells. Here, we showed that the Yersinia inner rod protein YscI directly interacts with the needle protein YscF inside the bacterial cells, and that this interaction depends on amino acid residues 83-102 in the carboxyl-terminus of YscI...
February 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28177834/cytogenetic-study-and-stripe-rust-response-of-the-derivatives-from-a-wheat-thinopyrum-intermedium-psathyrostachys-huashanica-trigeneric-hybrid
#7
Hou-Yang Kang, Lin Tang, Dai-Yan Li, Cheng-Dou Diao, Wei Zhu, Yao Tang, Yi Wang, Xing Fan, Li-Li Xu, Jian Zeng, Li-Na Sha, Xiao-Fang Yu, Hai-Qin Zhang, Yong-Hong Zhou
To transfer multiple desirable alien genes into common wheat, we previously reported a new trigeneric hybrid synthesized by crossing a wheat - Thinopyrum intermedium partial amphiploid with wheat - Psathyrostachys huashanica amphiploid. Here, the meiotic behavior, chromosome constitution, and stripe rust resistance of F5 derivatives from the wheat - Th. intermedium - P. huashanica trigeneric hybrid were studied. Cytological analysis indicated the F5 progenies had chromosome numbers of 42-50 (average 44.96)...
December 10, 2016: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/28168704/positron-emission-tomography-with-additional-%C3%AE-ray-detectors-for-multiple-tracer-imaging
#8
Tomonori Fukuchi, Takashi Okauchi, Mika Shigeta, Seiichi Yamamoto, Yasuyoshi Watanabe, Shuichi Enomoto
PURPOSE: Positron emission tomography (PET) is a useful imaging modality that quantifies the physiological distributions of radiolabeled tracers in vivo in humans and animals. However, this technique is unsuitable for multiple-tracer imaging because the annihilation photons used for PET imaging have a fixed energy regardless of the selection of the radionuclide tracer. This study developed a multi-isotope PET (MI-PET) system and evaluated its imaging performance. METHODS: Our MI-PET system is composed of a PET system and additional γ-ray detectors...
February 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28123444/the-presence-of-autoantibodies-to-cytoplasmic-rod-and-ring-particles-in-the-serum-of-patients-with-chronic-hepatitis-c-virus-infection
#9
Fatemeh Afsharzadeh, Farah Bokharaei-Salim, Maryam Esghaei, Seyed Hamidreza Monavari, Shahin Merat, Hossein Poustchi, Arghavan Haj-Sheykholeslami, Hossein Keyvani
BACKGROUND: Chronic hepatitis C virus (HCV) is associated with extra hepatic autoimmune disorders, while peg-IFNa-2a/RBV combination therapy may exacerbate these conditions. Autoantibodies to cytoplasmic structures, called rod and ring particles (RR), have strong associations with these patients and are identified by HEp-2 cells. OBJECTIVES: Our purpose was to study the correlation of autoantibodies to cytoplasmic rod and ring particles in the serum of patients with chronic HCV infection with their response to standard therapy...
December 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28115243/intravaginal-immunisation-using-a-novel-antigen-releasing-ring-device-elicits-robust-vaccine-antigen-specific-systemic-and-mucosal-humoral-immune-responses
#10
Paul F McKay, Jamie F S Mann, Aditya Pattani, Vicky Kett, Yoann Aldon, Deborah King, R Karl Malcolm, Robin J Shattock
The generation of effective levels of antigen-specific immunity at the mucosal sites of pathogen entry is a key goal for vaccinologists. We explored topical vaginal application as an approach to initiate local antigen-specific immunity, enhance previously existing systemic immunity or re-target responses to the mucosae. To deliver a protein vaccine formulation to the vaginal mucosal surface, we used a novel vaginal ring device comprising a silicone elastomer body into which three freeze-dried, rod-shaped, hydroxypropylmethylcellulose inserts were incorporated...
March 10, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28102949/simultaneous-pet-mr-imaging-with-a-radio-frequency-penetrable-pet-insert
#11
Alexander M Grant, Brian J Lee, Chen-Ming Chang, Craig S Levin
PURPOSE: A brain sized radio frequency (RF)-penetrable PET insert has been designed for simultaneous operation with MRI systems. This system takes advantage of electro-optical coupling and battery power to electrically float the PET insert relative to the MRI ground, permitting RF signals to be transmitted through small gaps between the modules that form the PET ring. This design facilitates the use of the built-in body coil for RF transmission and thus could be inserted into any existing MR site wishing to achieve simultaneous PET/MR imaging...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28101860/the-structure-and-topology-of-%C3%AE-helical-coiled-coils
#12
Andrei N Lupas, Jens Bassler, Stanislaw Dunin-Horkawicz
α-Helical coiled coils constitute one of the most diverse folds yet described. They range in length over two orders of magnitude; they form rods, segmented ropes, barrels, funnels, sheets, spirals, and rings, which encompass anywhere from two to more than 20 helices in parallel or antiparallel orientation; they assume different helix crossing angles, degrees of supercoiling, and packing geometries. This structural diversity supports a wide range of biological functions, allowing them to form mechanically rigid structures, provide levers for molecular motors, project domains across large distances, mediate oligomerization, transduce conformational changes and facilitate the transport of other molecules...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28097210/preclinical-positron-emission-tomography-scanner-based-on-a-monolithic-annulus-of-scintillator-initial-design-study
#13
Alexander V Stolin, Peter F Martone, Gangadhar Jaliparthi, Raymond R Raylman
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28056120/clinical-characterization-of-cngb1-related-autosomal-recessive-retinitis-pigmentosa
#14
Sarah Hull, Marcella Attanasio, Gavin Arno, Keren Carss, Anthony G Robson, Dorothy A Thompson, Vincent Plagnol, Michel Michaelides, Graham E Holder, Robert H Henderson, F Lucy Raymond, Anthony T Moore, Andrew R Webster
Importance: There are limited published data on the phenotype of retinitis pigmentosa (RP) related to CNGB1 variants. These data are needed both for prognostic counseling of patients and for understanding potential treatment windows. Objective: To describe the detailed clinical and molecular genetic findings in a series of patients with RP with likely pathogenic variants in CNGB1. Design, Setting, and Participants: In this case series, 10 patients from 9 families underwent full ophthalmologic examination...
January 5, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28046477/we-de-201-03-combined-use-of-192ir-60co-and-169yb-sources-with-the-novel-direction-modulated-brachytherapy-tandem-applicator-for-high-dose-rate-brachytherapy-planning-of-cervical-cancer
#15
H Safigholi, D Han, S Mashouf, A Soliman, A S Meigooni, A Owrangi, W Y Song
PURPOSE: To evaluate the improvement in plan quality when various combinations of 192Ir, 60Co, and 169Yb sources are used in combination with a novel direction modulated brachytherapy (DMBT) tandem applicator for high dose rate brachytherapy of cervical cancer. METHODS: The proposed DMBT tandem applicator is designed for image-guided adaptive brachytherapy (IGABT), especially MRI, of cervical cancer. It has 6 peripheral holes of 1.3-mm width, grooved along a 5.4-mm diameter nonmagnetic tungsten alloy rod of density 18...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045540/characterization-of-pegylated-liposomal-mitomycin-c-lipid-based-prodrug-promitil%C3%A2-by-high-sensitivity-differential-scanning-calorimetry-and-cryogenic-transmission-electron-microscopy
#16
Xiaohui Wei, Yogita Patil, Patricia Ohana, Yasmine Amitay, Hilary Shmeeda, Alberto Gabizon, Yechezkel Barenholz
The effect of a lipidated prodrug of mitomycin C (MLP) on the membrane of a pegylated liposome formulation (PL-MLP), also known as Promitil®, was characterized through high-sensitivity differential scanning calorimetry (DSC), and cryo-TEM. The thermodynamic analysis demonstrated that MLP led to the formation of heterogeneous domains in the membrane plane of PL-MLP. MLP concentrated in prodrug-rich domains, arranged in high-ordered crystal-like structures, as suggested by the sharp and high enthalpy endotherm in the 1st heating scanning...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28010044/the-gpsb-files-the-truth-is-out-there
#17
Richard J Lewis
Peptidoglycan (PG), an essential stress-bearing component of the bacterial cell wall, is synthesised by penicillin binding proteins (PBPs). PG synthesis at the cell division septum is necessary for constructing new poles of progeny cells, and cells cannot elongate without inserting new PG in the side-wall. The cell division regulator GpsB appears to co-ordinate PG synthesis at the septum during division and at the side-wall during elongation in rod-shaped and ovococcoid Gram-positive bacteria. How the control over PG synthesis is exerted is unknown...
December 23, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27973793/envisaging-structural-insight-of-a-terminally-protected-proline-dipeptide-by-raman-spectroscopy-and-density-functional-theory-analyses
#18
Supriya Das, Uttam Pal, Moumita Chatterjee, Sumit Kumar Pramanik, Biswadip Banerji, Nakul C Maiti
The proline residue in a protein sequence generates constraints to its secondary structure as the associated torsion angles become a part of the heterocyclic ring. It becomes more significant when two consecutive proline residues link via amide linkage and produce additional configurational constraint to a protein's folding and stability. In the current manuscript we have illustrated conformation preference of a novel dipeptide, (R)-tert-butyl 2-((S)-2-(methoxycarbonyl)pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate...
December 15, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27958468/improving-the-absorption-of-a-plasmonic-absorber-using-a-single-layer-of-graphene-at-telecommunication-wavelengths
#19
Mohammad Sadegh Zare, Najmeh Nozhat, Reza Rashiditabar
In this paper, a plasmonic absorber composed of a single layer of graphene over a metal film and separated by a 5 nm thin silica layer has been proposed. The metal film consists of two L-shaped grooves and a ring groove between the silver rods, and surrounding the silver cylindrical ring is a square of silica. The absorption of the proposed structure without the graphene is 0.85, and it is enhanced to 0.98 with a single layer of graphene in the near-infrared region. This absorption enhancement is because of the light and graphene interaction, which is reinforced by the localized surface plasmon resonance in the grooves...
December 1, 2016: Applied Optics
https://www.readbyqxmd.com/read/27933260/use-of-a-10-22%C3%A2-m-diameter-epb-shield-a-case-study-in-beijing-subway-construction
#20
Xinggao Li, Dajun Yuan, Yuhai Guo, Zhiyong Cai
INTRODUCTION: Beijing subway line 14 includes four stations and approximately 2.8 km of tunnels between the Dongfengbeiqiao and Jingshunlu areas of the city. Due to the surface and underground space limitations of this section, a double-track running tunnel instead of two single-track running tunnels was adopted to connect the two stations. The double-track tunnels were excavated by a 10.22 m diameter earth pressure balance (EPB) shield. It was the first time that an EPB shield more than 10 m in diameter was used in Beijing subway construction...
2016: SpringerPlus
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