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(Skin metastasis) melanoma

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https://www.readbyqxmd.com/read/29614021/non-metastatic-cutaneous-melanoma-induces-chronodisruption-in-central-and-peripheral-circadian-clocks
#1
Leonardo Vinícius Monteiro de Assis, Maria Nathália Moraes, Keila Karoline Magalhães-Marques, Gabriela Sarti Kinker, Sanseray da Silveira Cruz-Machado, Ana Maria de Lauro Castrucci
The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME) and macro-environments (TMaE) in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h...
April 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29596115/sensitization-of-recombinant-human-tumor-necrosis-factor-related-apoptosis-inducing-ligand-resistant-malignant-melanomas-by-quercetin
#2
Katherine A Turner, Jasmine M Manouchehri, Michael Kalafatis
Malignant melanoma is the most commonly diagnosed skin cancer associated with a high rate of metastasis. Low-stage melanoma is easily treated, but metastatic malignant melanoma is an extremely treatment-resistant malignancy with low survival rates. The application of recombinant human tumor necrosis factor-related apoptosis-inducing ligand (rhTRAIL) for the treatment of metastatic malignant melanoma holds considerable promise because of its selective proapoptotic activity towards cancer cells and not nontransformed cells...
March 28, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29575271/oct-image-atlas-of-healthy-skin-on-sun-exposed-areas
#3
S O'Leary, A Fotouhi, D Turk, P Sriranga, A Rajabi-Estarabadi, K Nouri, S Daveluy, D Mehregan, M Nasiriavanaki
BACKGROUND: Skin cancer represents the most prevalent type of cancer in the United States. Excision of these lesions can leave significant scarring, and a delay in the diagnosis of malignant melanoma could result in metastasis or death. Therefore, developing technology and criteria to accurately diagnose these cancers is of particular importance to the medical community. While biopsy can lead to scarring and infections, dermoscopy and confocal microscopy offer noninvasive imaging methods but are also limited in their ability to determine tumor depth and margins...
March 25, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29570170/fatty-acid-receptor-gpr120-a-novel-marker-for-human-melanoma
#4
Johannes Kleemann, Igor Hrgovic, Jan Ter-Nedden, Pia Kleimann, Katja Steinhorst, Katja Härle, Jutta Müller, Roland Kaufmann, Markus Meissner, Stefan Kippenberger
The correlation between ultraviolet radiation of the skin and melanoma incidence in humans is well established. Interestingly, epidemiologic data suggest also a correlation to an increased BMI pointing to metabolic trigger factors in melanoma pathogenesis. To substantiate this connection, we studied the expression of G-protein-coupled receptor 120 (GPR120), a receptor sensitive to unsaturated long-chain free fatty acids in melanoma tissues. One-hundred fourteen tissue sections histologically confirmed as nevi (n=32), primary melanoma (n=39), and melanoma metastasis (n=43) were immunohistochemically stained against GPR120...
March 21, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29568946/gefitinib-inhibits-malignant-melanoma-cells-through-the-vegf-akt-signaling-pathway
#5
Xuefeng Wan, Yalin Zhu, Lijuan Zhang, Wei Hou
Malignant melanoma (MM) is caused by melanophore cancerization in tissue pigmentation regions, leading to skin, mucous membrane, eye and central nervous system carcinogenesis. The incidence of MM has increased in previous years, and it has become the primary cause of skin cancer‑associated mortality in developed countries. MM is characterized as highly malignant and readily metastasized, and has a poor prognosis. Targeting angiogenesis is an important method for MM treatment. As an important proangiogenic factor in tumor growth and metastasis, vascular endothelial growth factor (VEGF) can promote neovascularization and increase vascular permeability...
March 13, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29560342/merkel-cell-carcinoma-an-update-and-immunotherapy
#6
REVIEW
Hiroshi Uchi
Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with frequent metastasis and death. MCC has a mortality rate of 30%, making it more lethal than malignant melanoma, and incidence of MCC has increased almost fourfold over the past 20 years in the USA. MCC has long been considered to be an immunogenic cancer because it occurs more frequently in immunosuppressed patients from organ transplant and HIV infection than in those with immunocompetent. Chronic UV light exposure and clonal integration of Merkel cell polyomavirus (MCPyV) are two major causative factors of MCC...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29552116/cdk5rap1-targeting-nf-%C3%AE%C2%BAb-signaling-pathway-in-human-malignant-melanoma-a375-cell-apoptosis
#7
Jikui Xiong, Yan Wang, Yanli Gu, Yadong Xue, Lin Dang, Yuzhen Li
Malignant melanoma is characterized by rapid deterioration, early metastasis and high mortality. Cdk5 regulatory subunit-associated protein 1 (CDK5RAP1), which catalyzes 2-methylthio (ms2 ) modification of mitochondrial transfer RNAs, has been reported to induce cancer cell apoptosis, by a phospho-c-Jun N-terminal kinase (p-JNK) signaling pathway. The present study was the first to report on the association between CDK5RAP1 deficiency and nuclear factor-κB (NF-κB) signaling pathway during the apoptosis process in human malignant melanoma (A375) cells...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29543494/piperlongumine-induces-apoptosis-in-human-melanoma-cells-via-reactive-oxygen-species-mediated-mitochondria-disruption
#8
Xuejiao Song, Tiantao Gao, Qian Lei, Lidan Zhang, Yuqin Yao, Jingyuan Xiong
Malignant melanoma is a devastating skin cancer due to its severe drug resistance and prompt metastasis. Piperlongumine is an anti-inflammation and tumor-suppressing natural product with defined structure. While numerous studies revealed exceptional inhibitory effects of piperlongumine on several carcinomas, few investigations were performed on melanoma. Therefore, the present study investigated the anti-tumor effects of piperlongumine on human melanoma cells in vitro, and explored the mechanisms of action...
March 15, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29542252/up-regulated-deubiquitinase-usp4-plays-an-oncogenic-role-in-melanoma
#9
Weinan Guo, Jinyuan Ma, Tianli Pei, Tao Zhao, Sen Guo, Xiuli Yi, Yu Liu, Shiyu Wang, Guannan Zhu, Zhe Jian, Tianwen Gao, Chunying Li, Wenjun Liao, Qiong Shi
Melanoma is the most malignant skin cancer with increasing incidence worldwide. Although innovative therapies such as BRAF inhibitor and immune checkpoint inhibitor have gained remarkable advances, metastatic melanoma remains an incurable disease for its notorious aggressiveness. Therefore, further clarification of the underlying mechanism of melanoma pathogenesis is critical for the improvement of melanoma therapy. Ubiquitination is an important regulatory event for cancer hallmarks and melanoma development, and the deubiquitinating enzymes including ubiquitin-specific peptidase (USP) families are greatly implicated in modulating cancer biology...
March 14, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29533281/a-case-of-a-malignant-cutaneous-mixed-tumor-chondroid-syringoma-of-the-scapula-treated-with-staged-margin-controlled-excision
#10
Karan Lal, Travis J Morrell, Michael Cunningham, Patrick OʼDonnell, Nikki A Levin, Kristine M Cornejo
Cutaneous mixed tumor (chondroid syringoma) is the cutaneous counterpart of pleomorphic adenoma of salivary glands, comprised of both epithelial and mesenchymal components. Malignant transformation is exceptionally rare, with only a few cases reported. We report a case of a malignant cutaneous mixed tumor in an 86-year-old white man who presented with a pink indurated plaque on his left scapula. He had a history of nonmelanoma skin cancers, a stage IB malignant melanoma of a lower extremity and Gleason 4 + 3 prostate cancer treated with brachytherapy, external beam irradiation, and bicalutamide...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29522273/integrative-analysis-of-competing-endogenous-rna-network-focusing-on-long-noncoding-rna-associated-with-progression-of-cutaneous-melanoma
#11
Siyi Xu, Jing Sui, Sheng Yang, Yufeng Liu, Yan Wang, Geyu Liang
Cutaneous melanoma (CM) is the most malignant tumor of skin cancers because of its rapid development and high mortality rate. Long noncoding RNAs (lncRNAs), which play essential roles in the tumorigenesis and metastasis of CM and interplay with microRNAs (miRNAs) and mRNAs, are hopefully considered to be efficient biomarkers to detect deterioration during the progression of CM to improve the prognosis. Bioinformatics analysis was fully applied to predict the vital lncRNAs and the associated miRNAs and mRNAs, which eventually constructed the competing endogenous RNA (ceRNA) network to explain the RNA expression patterns in the progression of CM...
March 9, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29505523/aberrations-and-clinical-significance-of-braf-in-malignant-melanoma-a-series-of-60-cases-in-chinese-uyghur
#12
Xiaojing Kang, Ying Zeng, Junqin Liang, Jing Li, Danyang Ren, Li Chai, Zhenzhu Sun, Shirong Yu, Xiujuan Wu, Wen Han, Weijia Wang
Malignant melanoma (MM) is a highly malignant melanocytic tumor, it occurs mostly in the skin, the mucous membrane close to the skin, but also in the tunicae rhagoides and the pia mater. The Uyghur is the largest ethnic group living in the Xinjiang Uyghur Autonomous Region of China, accounting for 46% of the total population of 20 million. Large-scale studies on MMs in Asian countries are limited. This study aimed to investigate BRAF mRNA expression and mutations in Chinese Uyghur patients with MMs and to identify the clinical features associated with these parameters...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29503569/role-of-ubenimex-as-an-anticancer-drug-and-its-synergistic-effect-with-akt-inhibitor-in-human-a375-and-a2058-cells
#13
Xiaoqing Wang, Yang Liu, Rongde Wu, Feng Guo, Lijuan Zhang, Mingyu Cui, Xiangyu Wu, Yongfei Zhang, Wei Liu
Background: Malignant melanoma (MM) is a malignant tumor produced by changes in melanocytes in the skin or other organs. In the classification of skin tumor mortality, skin melanoma ranks the highest. Ubenimex, an Aminopeptidase N (APN) inhibitor, is now widely used for cancer as an adjunct therapy, conferring antitumor effects. Apoptosis and the induction of autophagy have both been found to be closely associated with tumor cell death. Methods: In this study, the A375 and A2058 cell lines were treated with ubenimex...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29484016/chimeric-monoclonal-antibody-cetuximab-targeting-epidermal-growth-factor-receptor-in-advanced-non-melanoma-skin-cancer
#14
REVIEW
Uwe Wollina, Georgi Tchernev, Torello Lotti
BACKGROUND: Non-melanoma skin cancer (NMSC) is the most common malignancy in humans. Targeted therapy with monoclonal antibody cetuximab is an option in case of advanced tumor or metastasis. AIM: We present and update of the use of cetuximab in NMSC searching PUBMED 2011-2017. METHODS: The monoclonal antibody cetuximab against epidermal growth factor receptor (EGFR) has been investigated for its use in NMSC during the years 2011 to 2017 by a PUBMED research using the following items: "Non-melanoma skin cancer AND cetuximab," "cutaneous squamous cell carcinoma AND cetuximab," and "basal cell carcinoma AND cetuximab", and "cetuximab AND skin toxicity"...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29484003/another-case-of-interdigital-located-metastasing-hematoma
#15
Georgi Tchernev, Ivan Pidakev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Interdigital spaces could be an area of affection of a various cutaneous conditions, most of them with benign origin. The spectrum of differential diagnosis of pigmented interdigital lesions with a recent occurrence is not so wide, in contrast. When considering pigmented lesions in the interdigital area, the most harmless differential diagnosis is a traumatic hematoma. But what would happen if we based our therapeutic behaviour or suspicious and unconfirmed harmless diagnosis, instead of considering the real life-threatening once with priority, if we kept in mind that acral lentiginous melanoma has rather an aggressive course and is the main cause of death in skin cancer patients? We present a case of misdiagnosed interdigital melanoma, treated as a hemangioma with curettage, with almost fatal consequences, in regard to uncontrolled tumor progression as a result of the wrong traumatic procedure in one hand, and the lack of adequate screening and follow up, leading to progress of the disease with lymph node metastasis and poor prognosis in general...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29429153/cancer-prevention-with-green-tea-and-its-principal-constituent-egcg-from-early-investigations-to-current-focus-on-human-cancer-stem-cells
#16
Hirota Fujiki, Tatsuro Watanabe, Eisaburo Sueoka, Anchalee Rawangkan, Masami Suganuma
Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i...
January 31, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29415335/high-density-of-m2-macrophages-in-acral-lentiginous-melanoma-compared-to-superficial-spreading-melanoma
#17
M Zúñiga-Castillo, N V Pereira, M N Sotto
AIMS: Acral lentiginous melanoma (ALM) is the most common type of melanoma in people with darker skin phototypes. There is some evidences that the etiology, pathogenesis, risk factors, and natural history of ALM differ from those of superficial spreading melanoma (SSM). ALM behaves more aggressively than SSM, but the biological explanation for these differences remains unknown. The presence of one subtype of macrophages, termed M2-macrophage (M2-M), has been found to be related to local progression, metastasis, and poor prognosis in several neoplasms...
February 7, 2018: Histopathology
https://www.readbyqxmd.com/read/29405038/systemic-treatments-for-metastatic-cutaneous-melanoma
#18
REVIEW
Sandro Pasquali, Andreas V Hadjinicolaou, Vanna Chiarion Sileni, Carlo Riccardo Rossi, Simone Mocellin
BACKGROUND: The prognosis of people with metastatic cutaneous melanoma, a skin cancer, is generally poor. Recently, new classes of drugs (e.g. immune checkpoint inhibitors and small-molecule targeted drugs) have significantly improved patient prognosis, which has drastically changed the landscape of melanoma therapeutic management. This is an update of a Cochrane Review published in 2000. OBJECTIVES: To assess the beneficial and harmful effects of systemic treatments for metastatic cutaneous melanoma...
February 6, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29397746/solid-in-oil-peptide-nanocarriers-for-transcutaneous-cancer-vaccine-delivery-against-melanoma
#19
Rie Wakabayashi, Masato Sakuragi, Shuto Kozaka, Yoshiro Tahara, Noriho Kamiya, Masahiro Goto
Cancer vaccines represent a prophylactic or therapeutic method of suppressing cancer by activating the adaptive immune system. The immune response is initiated by the delivery of tumor antigens to antigen presenting cells (APCs). The use of peptides, as vaccine antigens, is advantageous especially in the availability and productivity of pure and defined antigens. However, their limited immunogenicity remains a major drawback and therefore the utilization of nanocarriers as a means of delivering antigens to target cells and/or the addition of immune stimulants have been investigated as an efficient peptide-based cancer vaccine...
February 5, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29388568/salinomycin-loaded-lipid-polymer-nanoparticles-with-anti-cd20-aptamers-selectively-suppress-human-cd20-melanoma-stem-cells
#20
Yi-Bin Zeng, Zuo-Chong Yu, Yan-Ni He, Tong Zhang, Ling-Bo Du, Yin-Mei Dong, Huai-Wen Chen, Ying-Ying Zhang, Wu-Qing Wang
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Salinomycin has emerged as an effective drug toward various CSCs. Due to its poor solubility, its therapeutic efficacy against melanoma CSCs has never been evaluated. In order to target CD20+ melanoma CSCs, we designed salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers (CD20-SA-NPs)...
February 2018: Acta Pharmacologica Sinica
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