Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Tao Liu, Jian-Ping Liu
BACKGROUND: Melanoma central nervous system (CNS) metastasis remains a leading cause of patient mortality, and the underlying pathological mechanism has not been fully elucidated, leading to a lack of effective therapeutic strategies. MATERIALS AND METHODS: In this study, we conducted an integrated analysis of single-cell transcriptomic data related to melanoma brain metastasis (MBM) and leptomeningeal metastasis (LMM). We focused on differences of subset composition and molecular expression of monocytes in blood, primary tumor, brain metastases, and leptomeningeal metastases...
April 2024: Skin Research and Technology
#2
JOURNAL ARTICLE
Xuejiao Liang, Jialiang Zhang, Chi Zhang, Haojie Zhai, Ping Yang, Ming Chen
We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules (mSHS) to enhance the delivery of the insoluble photosensitizer protoporphyrin IX (PpIX) into deep skin layers and mediate photodynamic therapy for metastatic melanoma in mice. The mSHS are dispersed sharp edged and rod-like micro-particles with a length of approximate 143.6 ± 6.4 μm and a specific surface area of 14.9 ± 3.4 m2 /g. The mSHS can be topically applied to the skin, adapting to any desired skin area and lesion site...
April 15, 2024: Journal of Nanobiotechnology
#3
JOURNAL ARTICLE
Vincenzo De Giorgi, Flavia Silvestri, Giovanni Cecchi, Federico Venturi, Biancamaria Zuccaro, Gabriella Perillo, Federica Cosso, Vincenza Maio, Sara Simi, Pietro Antonini, Serena Pillozzi, Lorenzo Antonuzzo, Daniela Massi, Laura Doni
Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case-control study was performed to identify clinical-dermoscopic and histopathological variables linked to local and distant metastases in melanomas ≤0.8 mm. Data from 1 January 2000 to 22 June 2022 were analyzed from two Italian skin cancer referral centers. Sixteen patients with ≤0.8 mm melanomas developing metastases were studied compared to controls without metastases over 5 years...
April 1, 2024: Cancers
#4
JOURNAL ARTICLE
Shantanu Srivatsa, Collin-Jamal Smith, Omar P Sangüeza, Jayson Miedema, Frances A Collichio, Paul B Googe
Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man...
April 4, 2024: American Journal of Dermatopathology
#5
JOURNAL ARTICLE
Jiaheng Xie, Dan Wu, Pengpeng Zhang, Songyun Zhao, Min Qi
Cutaneous melanoma poses a formidable challenge within the field of oncology, marked by its aggressive nature and capacity for metastasis. Despite extensive research uncovering numerous genetic and molecular contributors to cutaneous melanoma development, there remains a critical knowledge gap concerning the role of lipids, notably low-density lipoprotein (LDL), in this lethal skin cancer. This article endeavours to bridge this knowledge gap by delving into the intricate interplay between LDL metabolism and cutaneous melanoma, shedding light on how lipids influence tumour progression, immune responses and potential therapeutic avenues...
April 2024: Experimental Dermatology
#6
JOURNAL ARTICLE
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier, before the diagnosis of the primary tumor. The progress in understanding the kinetics of cancer dissemination is limited by the lack of animal models that accurately mimic disease progression. We have established a xenograft model of human melanoma that spontaneously metastasizes to lymph nodes and lungs...
April 3, 2024: Scientific Reports
#7
JOURNAL ARTICLE
Litong Sun, Shizhen Bin, Chenghui Huang, Qi Wang
Circular RNAs (circRNAs) play important roles in cancer occurrence and progression. To explore and elucidate the clinical significance of specific circular RNA in melanoma and its potential molecular mechanism. CircROR1 expression in melanoma cells and tissues was confirmed by qRT-PCR and ISH. qRT-PCR and Western blotting were performed to measure the levels of CCNE1, KAT2A, MMP9 and TIMP2. MTT, Transwell and wound healing assays were performed to evaluate cell proliferation, invasion and metastasis. A xenograft mouse model was established to further verify the CircROR1/CCNE1 axis in vivo...
April 2024: Experimental Dermatology
#8
JOURNAL ARTICLE
Takuya Nishio, Taku Maeda, Kosuke Ishikawa, Naoki Murao, Kanako Fuyama, Yuhei Yamamoto, Toshihiko Hayashi
BACKGROUND: This study aimed to clarify the relationship between primary site and lymphatic drainage pattern for malignant skin tumors in the head and neck region. Malignant melanoma and squamous cell carcinoma in the head and neck region are known to have poor prognosis because of lymph node metastasis. Nevertheless, numerous aspects of lymphatic drainage patterns remain elusive. METHODS: We statistically analyzed data of 47 patients with malignant skin tumors in the head and neck region...
March 30, 2024: International Journal of Clinical Oncology
#9
JOURNAL ARTICLE
Fatemehsadat Hosseini, Abdolreza Ahmadi, Halimeh Hassanzade, Shahin Gharedaghi, Fatemeh B Rassouli, Khadijeh Jamialahmadi
Melanoma, the most invasive form of skin cancer, shows a rising incidence trend in industrial countries. Since the main reason for the failure of current therapeutic approaches against melanoma is metastasis, there is a great interest in introducing effective natural agents to combat melanoma cell migration and invasion. Auraptene (AUR) is the most abundant coumarin derivative in nature with valuable pharmaceutical effects. In this study, we aimed to investigate whether AUR could induce inhibitory effects on the migration and invasion of melanoma cells...
March 25, 2024: European Journal of Pharmacology
#10
JOURNAL ARTICLE
Yuanyuan Shang, Haiqian Yang, Jian Cui, Lipeng Wang, Le Wang, Yuan Wang, Miao-Miao Zhao, Pei-Yao Yu, Hui Qiao, Wen-Jun Yang
Malignant melanoma (MM) is a highly aggressive and deadly form of skin cancer, primarily caused by recurrence and metastasis. Therefore, it is crucial to investigate the regulatory mechanisms underlying melanoma recurrence and metastasis. Our study has identified a potential targeted regulatory relationship between LINC02202, miR-526b-3p and XBP1 in malignant melanoma. Through the regulation of the miR-526b-3p/XBP1 signalling pathway, LINC02202 may play a role in tumour progression and immune infiltration and inhibiting the expression of LINC02202 can increase the efficacy of immunotherapy for melanoma...
April 2024: Journal of Cellular and Molecular Medicine
#11
JOURNAL ARTICLE
Maria Clara Pinheiro Duarte Sampaio, Renata Virgínia Cavalcanti Santos, Amanda Pinheiro de Barros Albuquerque, Ana Karine de Araújo Soares, Marina Ferraz Cordeiro, Michelle Melgarejo da Rosa, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo
Melanoma, an infrequent yet significant variant of skin cancer, emerges as a primary cause of brain metastasis among various malignancies. Despite recognizing the involvement of inflammatory molecules, particularly chemokines, in shaping the metastatic microenvironment, the intricate cellular signaling mechanisms underlying cerebral metastasis remain elusive. In our pursuit to unravel the role of cytokines in melanoma metastasis, we devised a protocol utilizing mixed cerebral cortical cells and SK-MEL-28 melanoma cell lines...
March 20, 2024: Journal of Interferon & Cytokine Research
#12
REVIEW
Mohammad Malekan, Nikolas K Haass, Ghasem Rahmatpour Rokni, Nasim Gholizadeh, Mohammad Ali Ebrahimzadeh, Armaghan Kazeminejad
Melanoma is responsible for most skin cancer-associated deaths globally. The progression of melanoma is influenced by a number of pathogenic processes. Understanding the VEGF/VEGFR axis, which includes VEGF-A, PlGF, VEGF-B, VEGF-C, and VEGF-D and their receptors, VEGFR-1, VEGFR-2, and VEGFR-3, is of great importance in melanoma due to its crucial role in angiogenesis. This axis generates multifactorial and complex cellular signaling, engaging the MAPK/ERK, PI3K/AKT, PKC, PLC-γ, and FAK signaling pathways...
March 18, 2024: Life Sciences
#13
JOURNAL ARTICLE
Weilin Cai, Minliang Chen
PURPOSE: Tumor growth induces the tumor margin to become a transition zone rich in immune cells. EVPL is a potential prognostic biomarker for melanoma. Melanoma is difficult to cure because of its high metastasis, so it is urgent to find effective genes to inhibit tumor progression and regulate tumor microenvironment. METHODS: Firstly, differentially expressed genes (DEGs) among normal skin, nevus and melanoma samples in GSE3189 were screened. Bioinformatics was used to further explore the hub genes and enriched pathways closely related to the inflammatory response of DEGs in melanoma...
2024: Journal of Inflammation Research
#14
JOURNAL ARTICLE
Dirk Schadendorf, Jason John Luke, Paolo A Ascierto, Georgina V Long, Piotr Rutkowski, Adnan Khattak, Michele Del Vecchio, Luis de la Cruz-Merino, Jacek Mackiewicz, Vanna Chiarion Sileni, John M Kirkwood, Caroline Robert, Jean-Jacques Grob, Reinhard Dummer, Matteo S Carlino, Yujie Zhao, Mizuho Kalabis, Clemens Krepler, Alexander Eggermont, Richard A Scolyer
BACKGROUND: Adjuvant pembrolizumab significantly improved recurrence-free survival (RFS) and distant metastasis-free survival (DMFS) versus placebo in the phase 3 KEYNOTE-716 study of resected stage IIB or IIC melanoma. At the prespecified third interim analysis (data cut-off, January 4, 2022), the HR for RFS in the overall population was 0.64 (95% CI, 0.50 to 0.84) and the HR for DMFS was 0.64 (95% CI, 0.47 to 0.88). We present a post hoc analysis of efficacy by subtypes defined by histopathologic characteristics...
March 13, 2024: Journal for Immunotherapy of Cancer
#15
JOURNAL ARTICLE
Danica Tiodorovic, Jelena Stojkovic-Filipovic, Ashfaq Marghoob, Giuseppe Argenziano, Susana Puig, Josep Malvehy, Linda Tognetti, Rubegni Pietro, Bengu Nisa Akay, Iris Zalaudek, Holger A Haenssle, Christine Müller-Christmann, Elisa Cinotti, Jean Luc Perrot, Pedro Zaballos, Renato Marchiori Bakos, Luc Thomas, Ketty Peris, Aimilios Lallas, Zoe Apalla, Juergen F Kreusch, Isabelle Tromme, Alexandros J Stratigos, Maria Antonietta Pizzichetta, Lidija Kandolf, Caterina Longo, Andreas Blum, Masaru Tanaka, Rainer Hofmann-Wellenhof, Andrija Jovic, John Paoli, Marija Buljan, Martina Espasandín-Arias, Horacio Cabo, Sonia Rodrigiez Saa, Gabriel Salerni, Gianluca Nazzaro, Grazyna Kaminska-Winciorek, Giovanni Damiani, Franciska Geszti, Harald Kittler
BACKGROUND: The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. OBJECTIVES: Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. METHODS: Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs. RESULTS: We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#16
JOURNAL ARTICLE
Hanwen Wang, Shixin Zhao, Hengdeng Liu, Yiling Liu, Zihui Zhang, Ziheng Zhou, Peng Wang, Shaohai Qi, Julin Xie
Background: N6-methyladenosine (m6 A) is the most common and abundant mRNA modification, playing an essential role in biological processes and tumor development. However, the role of m6 A methylation in skin cutaneous melanoma (SKCM) is not yet clear. This study analyzed the expression of m6 A-related functional genes in SKCM and aimed to explore the key demethylase ALKBH5 mediated m6 A modification and its potential mechanism in human SKCM. Methods: Based on public databases, the m6 A-related gene expression landscape in SKCM was portrayed...
2024: International Journal of Biological Sciences
#17
JOURNAL ARTICLE
Gloria E Marino-Bravante, Alexis E Carey, Laura Hüser, Agrani Dixit, Vania Wang, Amanpreet Kaur, Ying Liu, Supeng Ding, Rahel Schnellmann, Sharon Gerecht, Luo Gu, T S Karin Eisinger-Mathason, Yash Chhabra, Ashani T Weeraratna
Melanoma, the most lethal form of skin cancer, often has worse outcomes in older patients. We previously demonstrated that an age-related decrease in the secreted extracellular matrix (ECM) protein HAPLN1 has a role in slowing melanoma progression. Here we show that HAPLN1 in the dermal ECM is sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression. Specifically, we show that HAPLN1 in the ECM increases hyaluronic acid and decreases endothelial cell expression of ICAM1...
March 12, 2024: Nature aging
#18
JOURNAL ARTICLE
Jui-Jen Chang, Yi-Chen Wang, Shu-Hui Yang, Ju-Yu Wu, Ming-Wei Chang, Hui-Min David Wang
BACKGROUND: Recently, the use of the tumor or its secretions as drug carriers has gradually become popular, with the advantages of high biocompatibility and enhanced drug delivery to specific cells. Melanoma is the most malignant tumor of all skin cancers; it is the most metastatic and, therefore, the most difficult to treat. The main purpose of this study is to develop nanovesicles with tumor cell membrane secretion properties to encapsulate target substances to enhance the therapeutic effect of cancer...
2024: International Journal of Nanomedicine
#19
JOURNAL ARTICLE
Zhen-Guo Zhang, Hong-Mei Zhu, Huai-Kang Hua
OBJECTIVE: This study aimed to investigate the role of Interleukin-11 receptor alpha (IL11RA) in skin cutaneous melanoma (SKCM) metastasis to the liver. METHODS: Human SKCM cell lines (A375, A375-MA2, SK-MEL-28, RPMI-7951) and primary dermal fibroblasts (HDFa) were utilized to assess IL11RA expression. IL11RA siRNA was transfected into RPMI-7951 and A375-MA2 cells for Wound healing and Transwell invasion assays. Il11ra knockout (KO) mice and wild-type (WT) mice were injected with B16-F10 cells into the spleen to evaluate hepatic melanoma metastasis...
March 2024: Skin Research and Technology
#20
JOURNAL ARTICLE
Camille Langbour, Johan Law-Wan, Rim Ben-Saad, Julia Zaragoza, Vimal Raj Nitish Gunness, Sofiane Mouzoune, Nada Ibrahim, Carine Salliot
No abstract text is available yet for this article.
December 1, 2023: European Journal of Dermatology: EJD
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
