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https://www.readbyqxmd.com/read/27914118/blue-lymphangitis-of-the-breast-after-breast-cancer-case-report
#1
Alexandra Arfi, Alice Clavier, Jean F Honart, Samy Ammari, Zahira Merabet, Christine Mateus, Julia Arfi-Rouche
Carcinomatous lymphangitis accounts for 5% of all skin metastases, but blue lymphangitis of the breast has never been described. We report a case of blue lymphangitis of the breast in a patient 11 years after treatment for ipsilateral breast cancer that was in full remission. Breast examination and imaging showed no other abnormalities. Skin biopsy revealed a carcinomatous-pigmented infiltration corresponding to melanoma metastasis, which helped highlight a primitive right flank injury. This case report emphasizes that a full body exam should always be performed with unusual presentation of breast cancer and reiterates the indispensable place of histology before any diagnosis...
December 3, 2016: Breast Journal
https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#2
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27895497/microrna-9-suppresses-the-growth-migration-and-invasion-of-malignant-melanoma-cells-via-targeting-nrp1
#3
Dan Xu, Xiaofeng Chen, Quanyong He, Chengqun Luo
MicroRNAs (miRs) are a class of small noncoding RNAs that negatively regulate the gene expression by directly binding to the 3' untranslated region of their target mRNA, thus resulting in mRNA degradation or translational repression. miR-9 has recently been demonstrated to play a role in the development and progression of malignant melanoma (MM), but the regulatory mechanism of miR-9 in the malignant phenotypes of MM still remains largely unknown. In this study, a total of 73 pairs of MM tissues and adjacent normal tissues were collected...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27895081/malignant-melanoma-of-cervix
#4
Mayank Gupta
A 68-year-old woman presented with symptoms of bleeding per vaginum. On examination, a growth was seen in the cervix, clinically considered to be squamous cell carcinoma. The growth was confined to the cervix and did not involve the parametria. However, on biopsy it was diagnosed as malignant melanoma. She underwent surgery elsewhere and was advised chemotherapy as these tumours are aggressive; however, she refused chemotherapy. She has been on regular follow-up and has an ongoing survival and disease-free period of more than 5 years...
November 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27853253/generation-of-metastatic-melanoma-specific-antibodies-by-affinity-purification
#5
Birgit Schütz, Anita Koppensteiner, David Schörghofer, Katharina Kinslechner, Gerald Timelthaler, Robert Eferl, Markus Hengstschläger, Albert Missbichler, Harald Hundsberger, Mario Mikula
Melanoma is the most aggressive type of skin cancer and one of the most frequent tumours in young adults. Identification of primary tumours prone to develop metastasis is of paramount importance for further patient stratification. However, till today, no markers exist that are routinely used to predict melanoma progression. To ameliorate this problem, we generated antiserum directed against metastatic melanoma tissue lysate and applied a novel approach to purify the obtained serum via consecutive affinity chromatography steps...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27837031/pharmacological-inhibition-of-myocardin-related-transcription-factor-pathway-blocks-lung-metastases-of-rhoc-overexpressing-melanoma
#6
Andrew J Haak, Kathryn M Appleton, Erika M Lisabeth, Sean Misek, Yajing Ji, Susan M Wade, Jessica L Bell, Cheryl E Rockwell, Merlin Airik, Melanie A Krook, Scott D Larsen, Monique E Verhaegen, Elizabeth R Lawlor, Richard R Neubig
Melanoma is the most dangerous form of skin cancer with the majority of deaths arising from metastatic disease. Evidence implicates Rho-activated gene transcription in melanoma metastasis mediated by the nuclear localization of the transcriptional coactivator, myocardin-related transcription factor (MRTF). Here, we highlight a role for Rho and MRTF signaling and its reversal by pharmacologic inhibition using in vitro and in vivo models of human melanoma growth and metastasis. Using two cellular models of melanoma, we clearly show that one cell type, SK-Mel-147, is highly metastatic, has high RhoC expression, and MRTF nuclear localization and activity...
November 11, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27825810/dss1-promoter-hypomethylation-and-overexpression-predict-poor-prognosis-in-melanoma-and-squamous-cell-carcinoma-patients
#7
Mario Venza, Maria Visalli, Teresa Catalano, Concetta Beninati, Diana Teti, Isabella Venza
Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved. Evaluation of DSS1 expression profile indicated that the gene is overexpressed in 112/130 cutaneous melanomas (86.1%), 41/64 uveal melanomas (64.1%), 67/82 mucosal melanomas (81.7%), and 61/75 SCC samples (81...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27813258/congenital-cutaneous-melanoma-in-a-dog
#8
Bruna Meyrer, Simone Passos Bianchi, Saulo Petinatti Pavarini, Daniel Guimarães Gerardi
BACKGROUND: Melanocytic tumours are derived from melanocytes and are common in older dogs with dark pigmented skin. Primary congenital cutaneous melanoma has been described in domestic mammals although there are no reports in the dog. HYPOTHESIS/OBJECTIVE: We describe a case of canine congenital cutaneous melanoma with rapid progression to metastasis and death. ANIMAL: A male, mixed breed dog was born with a circular ulcerated lesion near the left ear...
November 4, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27775691/targeting-melanoma-with-front-line-therapy-does-not-abrogate-nodal-expressing-tumor-cells
#9
Mary Jc Hendrix, Irawati Kandela, Andrew P Mazar, Elisabeth A Seftor, Richard Eb Seftor, Naira V Margaryan, Luigi Strizzi, George F Murphy, Georgina V Long, Richard A Scolyer
Metastatic melanoma is a highly aggressive skin cancer with a poor prognosis. It is the leading cause of skin cancer deaths with a median overall survival for advanced-stage metastatic disease of <6 months. Despite advances in the field with conventional and targeted therapies, the heterogeneity of melanoma poses the greatest ongoing challenge, ultimately leading to relapse and progression to a more drug-resistant tumor in most patients. Particularly noteworthy are recent findings, indicating that these therapies exert selective pressure on tumors resulting in the activation of pathways associated with cancer stem cells that are unresponsive to current therapy...
October 24, 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27774842/epidemiology-management-and-survival-outcomes-of-primary-cutaneous-melanoma-a-ten-year-overview
#10
M M F Aubuchon, L J J Bolt, M L G Janssen-Heijnen, S T H P Verleisdonk-Bolhaar, A van Marion, C L H van Berlo
BACKGROUND: Malignant melanoma (MM) is the most aggressive type of skin cancer, accounting for 90% of all the skin cancer mortality. The objective of this study was providing an overview of current patient- and tumour characteristics, treatment strategies, complications and survival in patients with MM over the past ten years. Hereby, an up-to-date view of every day clinical practice is obtained. METHODS: Files of patients treated for primary cutaneous melanoma (n = 686) in the VieCuri Medical Centre in the Netherlands between January 2002 and December 2013 were retrospectively reviewed...
October 23, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27766546/management-of-skin-cancer-in-the-high-risk-patient
#11
James W Behan, Adam Sutton, Ashley Wysong
Skin cancer is the most common of human cancers and outnumbers all other types of cancer combined in the USA by over threefold. The majority of non-melanoma skin cancers are easily treated with surgery or locally destructive techniques performed under local anesthesia in the cost-effective outpatient setting. However, there is a subset of "high-risk" cases that prove challenging in terms of morbidity, mortality, adjuvant treatment required, as well as overall cost to the health care system. In our opinion, the term "high risk" when applied to skin cancer can mean one of three things: a high-risk tumor with aggressive histologic and/or clinical features with an elevated risk for local recurrence or regional/distant metastasis, a high-risk patient with the ongoing development of multiple skin cancers, and a high-risk patient based on immunosuppression...
December 2016: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/27752289/mechanical-properties-of-the-tumor-stromal-microenvironment-probed-in-vitro-and-ex-vivo-by-in-situ-calibrated-optical-trap-based-active-microrheology
#12
Jack R Staunton, Wilfred Vieira, King Leung Fung, Ross Lake, Alexus Devine, Kandice Tanner
One of the hallmarks of the malignant transformation of epithelial tissue is the modulation of stromal components of the microenvironment. In particular, aberrant extracellular matrix (ECM) remodeling and stiffening enhances tumor growth and survival and promotes metastasis. Type I collagen is one of the major ECM components. It serves as a scaffold protein in the stroma contributing to the tissue's mechanical properties, imparting tensile strength and rigidity to tissues such as those of the skin, tendons, and lungs...
September 2016: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/27718152/differential-bmi1-twist1-snai2-mrna-expression-pattern-correlation-with-malignancy-type-in-a-spectrum-of-common-cutaneous-malignancies-basal-cell-carcinoma-squamous-cell-carcinoma-and-melanoma
#13
F Vand-Rajabpour, N Sadeghipour, S Saee-Rad, H Fathi, P Noormohammadpour, M Yaseri, K K Hesari, Z Bagherpour, M Tabrizi
PURPOSE: Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) can be used as a unique model to identify molecular mechanisms to distinguish rarely metastatic (BCC), often metastatic (SCC) and most metastatic (melanoma) cancer. It is known that epithelial-mesenchymal transition and stemness transcription factors (TWIST1, SNAI2/SLUG, and BMI1) play an important role in metastasis and their dysregulation has been demonstrated in metastatic cancers. We hypothesized that this spectrum of cutaneous cancers (BCC, SCC, and melanoma) would be a unique cancer model system to elucidate steps toward cancer invasion and metastasis...
October 7, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27706596/detecting-the-potential-cancer-association-or-metastasis-by-multi-omics-data-analysis
#14
L Hua, W Y Zheng, H Xia, P Zhou
Comprehensive multi-omics data analyses have become an important means for understanding cancer incidence and progression largely driven by the availability of high-throughput sequencing technologies for genomes, proteomes, and transcriptomes. However, how tumor cells from the site of origin of the cancer begin to grow in other sites of the body is very poorly understood. In order to examine potential connections between different cancers and to gain an insight into the metastatic process, we conducted a multi-omics data analysis using data deposited in The Cancer Genome Atlas database...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27695188/melanoma-to-the-heart
#15
Charis G Durham, James A Hall, Erica J Fidone, Ryan Mack, Austin L Metting
Malignant melanoma is the third most common skin cancer yet has the highest mortality rate due to its predilection for metastasis. While the diagnosis of antemortem melanoma with cardiac metastasis is relatively uncommon, diagnosing malignant melanoma itself by first identifying a cardiac metastasis is even more rare. This vignette describes an antemortem diagnosis of melanoma in a 50-year-old woman through identification of metastasis to multiple sites, including the tricuspid valve.
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27685530/metastasis-of-two-malignant-tumors-of-different-genesis-in-axillary-lymph-node-a-case-report
#16
A V Rusin, O V Petrosov, A I Chumak, V M Kushnir
This case report describes a rare clinical condition: metastasis of synchronous multiple primary tumors - skin melanoma and breast cancer in one axillary lymph node, confirmed with the results of clinical, morphological and immunohistochemical study of surgical material from 40 year-old woman.
September 2016: Experimental Oncology
https://www.readbyqxmd.com/read/27665942/cyr61-suppresses-growth-of-human-malignant-melanoma
#17
Jun Chen, Yang Liu, Qilin Sun, Beiqing Wang, Ningli Li, Xiangdong Chen
Cysteine-rich protein 61 (CCN1/CYR61) is an important marker of proliferation and metastasis in malignant melanoma, making it a potential target for melanoma treatment. In this study, we compared the expression of CRY61 in Chinese patients with malignant melanoma with its expression in patients with other skin tumors or with no skin pathological conditions. We examined the effects of anti-human CYR61 monoclonal antibody on proliferation and evaluated the changes in CYR61 expression and cell proliferation in response to treatment with either epirubicin or interferon (IFN)-α...
September 23, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27631871/rare-association-of-cystic-squamous-cell-carcinoma-and-small-lymphocytic-b%C3%A2-cell-lymphoma-successful-surgical-approach
#18
Uwe Wollina, Jacqueline Schönlebe, Birgit Heinig, Andreas Nowak, Anastasiya Atanasova Chokoeva, Georgi Tchernev
Non-melanoma skin cancer is the most common type of cutaneous neoplasm worldwide. While basal cell carcinoma is the most common tumor, squamous cell carcinoma (SCC) causes higher morbidity and has a risk of metastatic spread, depending on immune status, tumor size, and desmoplastic growth. We reported the case of a 77 year old male patient with retroauricular tumor, which started growing 3 years ago and was excised, buth relapsed three times. The initial diagnosis was infundibular cyst. Delayed Mohs surgery was performed, as was an additional open lymph node biopsy of the patient's right groin, on the occasion of an indolent swelling of the same which developed within 3 months...
September 8, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27622047/adjuvant-dendritic-cell-vaccination-induces-tumor-specific-immune-responses-in-the-majority-of-stage-iii-melanoma-patients
#19
Steve Boudewijns, Kalijn F Bol, Gerty Schreibelt, Harm Westdorp, Johannes C Textor, Michelle M van Rossum, Nicole M Scharenborg, Annemiek J de Boer, Mandy W M M van de Rakt, Jeanne M Pots, Tom G M van Oorschot, Tjitske Duiveman-de Boer, Michel A Olde Nordkamp, Wilmy S E C van Meeteren, Winette T A van der Graaf, Johannes J Bonenkamp, Johannes H W de Wilt, Erik H J G Aarntzen, Cornelis J A Punt, Winald R Gerritsen, Carl G Figdor, I Jolanda M de Vries
PURPOSE: To determine the effectiveness of adjuvant dendritic cell (DC) vaccination to induce tumor-specific immunological responses in stage III melanoma patients. EXPERIMENTAL DESIGN: Retrospective analysis of stage III melanoma patients, vaccinated with autologous monocyte-derived DC loaded with tumor-associated antigens (TAA) gp100 and tyrosinase after radical lymph node dissection. Skin-test infiltrating lymphocytes (SKILs) obtained from delayed-type hypersensitivity skin-test biopsies were analyzed for the presence of TAA-specific CD8(+) T cells by tetrameric MHC-peptide complexes and by functional TAA-specific T cell assays, defined by peptide-recognition (T2 cells) and/or tumor-recognition (BLM and/or MEL624) with specific production of Th1 cytokines and no Th2 cytokines...
July 2016: Oncoimmunology
https://www.readbyqxmd.com/read/27602212/expression-of-microphthalmia-transcription-factor-s100-protein-and-hmb-45-in-malignant-melanoma-and-pigmented-nevi
#20
Jianxin Xia, Yanlong Wang, Fuqiu Li, Jinfeng Wang, Yan Mu, Xianglin Mei, Xue Li, Wenjing Zhu, Xianhua Jin, Kai Yu
Malignant melanoma (MM) is a type of malignant tumor, which originates from neural crest melanocytes. MM progresses rapidly and results in a high mortality rate. The present study aims to investigate the expression of microphthalmia transcription factor (MITF), the S100 protein, and HMB-45 in MM and pigmented nevi. A total of 32 MM samples (including three skin metastasis, three lymph node metastasis and two spindle cell MM samples), two Spitz nevus samples, four pigmented nevus samples and two blue nevus samples were collected...
September 2016: Biomedical Reports
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