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(Cutaneous metastasis) melanoma

Peter E Hutchinson, John A Halsall, Silvia Popovici, Eftychios Papadogeorgakis, Joy E Osborne, Ian R Powley, Deepthi Dasari, Gerald Saldanha, James H Pringle
The aims of this study were to investigate, in cutaneous malignant melanoma (MM), the integrity of nuclear vitamin D receptor (VDR) signalling, as implied by VDR subcellular location; to investigate the relationship between VDR and tumour progression and the inhibitory effect on VDR by mitogen-activated protein kinase (MAPK) overactivity. Archived tissue from 34 benign melanocytic naevi, 149 MMs and 44 matched metastases were stained by immunohistochemistry for VDR and a subset of primary MMs were stained for phosphorylated-extracellular signal-regulated kinase as a marker of MAPK activity...
July 12, 2018: Melanoma Research
Bradley N Greenhaw, John A Zitelli, David G Brodland
BACKGROUND: Cutaneous melanomas (CMs) with similar clinical and histopathologic features can harbor differing capacities for metastasis. A validated gene expression profile (GEP) test offers prognostic information by classifying CMs as low risk (Class 1A/1B) or high risk (Class 2A/2B) for metastasis. OBJECTIVE: The authors sought to perform an independent study of the predictive accuracy of the GEP test, to determine what clinical and histopathologic features predict high-risk classification, and to evaluate how intermediate classes (1B & 2A) performed clinically...
July 9, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Giulia Fornabaio, Raymond L Barnhill, Claire Lugassy, Laurent A Bentolila, Nathalie Cassoux, Sergio Roman-Roman, Samar Alsafadi, Filippo Del Bene
Cutaneous melanoma is a highly aggressive cancer with a propensity for distant metastasis to various organs. In contrast, melanoma arising in pigmented uveal layers of the eye metastasizes mostly in the liver. The mechanisms of these metastases, which are ultimately resistant to therapy, are still unclear. Metastasis via intravascular dissemination of tumour cells is widely accepted as a central paradigm. However, we have previously described an alternative mode of tumour dissemination, extravascular migratory metastasis, based on clinical and experimental data...
July 11, 2018: Scientific Reports
Isabella Venza, Maria Visalli, Rosaria Oteri, Concetta Beninati, Diana Teti, Mario Venza
Genistein, a natural isoflavone found in soybean products, is considered as a powerful anti-cancer agent, although the involved mechanisms are not fully understood. There is a growing body of evidence that, among the genes inhibited by genistein and responsible for cell cycle progression, invasion, metastasis, and angiogenesis, IL-8 occupies a relevant place. On the other hand, it is equally well documented that IL-8 is upregulated by prostaglandin E2 (PGE2 ) in different pathological conditions, particularly in neoplastic disease...
July 5, 2018: International Immunopharmacology
Ali C Ravanpay, Ariana Barkley, Gabrielle A White-Dzuro, Patrick J Cimino, Luis F Gonzalez-Cuyar, Christina Lockwood, Lia M Halasz, Fuki M Hisama, Manuel Ferreira
Rhabdoid meningiomas are rare WHO grade 3 tumors that tend to follow an aggressive course. Pediatric rhabdoid meningioma is an exceedingly rare pathology commonly found on recurrent tumors in conjunction with lower grade meningioma pathology. Here, we present the case of a pediatric patient who came to us with a giant rhabdoid meningioma occurring in the right tentorium and invading the torcula and multiple venous structures, including the right jugular vein, down to the level of the right atrium. The patient underwent five separate surgeries for management of this tumor...
July 5, 2018: World Neurosurgery
Emmanuelle Bourneuf, Jordi Estellé, Amandine Blin, Françoise Créchet, Maria Del Pilar Schneider, Hélène Gilbert, Myriam Brossard, Amaury Vaysse, Mark Lathrop, Silvia Vincent-Naulleau, Florence Demenais
Despite major advances, it is estimated that a large part of melanoma predisposing genes remains to be discovered. Animal models of spontaneous diseases are valuable tools and experimental crosses can be used to identify and fine-map new susceptibility loci associated with melanoma. We performed a Genome-Wide Association Study (GWAS) of melanoma occurrence and progression (clinical ulceration and presence of metastasis) in a porcine model of spontaneous melanoma, the MeLiM pig. Five loci on chromosomes 2, 5, 7, 8 and 16 showed genome-wide significant associations ( p < 5 × 10-6 ) with either one of these phenotypes...
June 12, 2018: Oncotarget
Houyu Ju, Liming Zhang, Lu Mao, Yuteng Wu, Shuli Liu, Min Ruan, Jingzhou Hu, Guoxin Ren
BACKGROUND & AIM: Oral mucosal melanoma (OMM) is a kind of malignancy with extremely rare morbidity. It exhibits a poorer biological behavior and clinical outcome compared with cutaneous melanoma. lncRNAs are endogenous cellular RNA transcripts with no protein-coding potential and are associated with oncogenesis through cis- or trans-acting mechanisms. Despite increased evidence that proved lncRNAs have vital roles in tumorigenesis of mucosal melanoma, little is known about their functions in the progress of lymph node dissemination of OMM...
June 27, 2018: Gene
Tyler A Janz, David M Neskey, Shaun A Nguyen, Eric J Lentsch
OBJECTIVE: To evaluate the frequency of brain metastasis at the time of diagnosis for patients with cutaneous head and neck melanoma (CHNM). METHODS: Patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 2010 to 2014 based on a diagnosis of CHNM using ICD O-3 histology codes and primary site location documentation. Patients were also included if they had a "yes" or "no" documented in the "Mets at Dx-Brain" category...
June 8, 2018: American Journal of Otolaryngology
Tariane Friedrich Foiato, Bruno Rafael Kunz Bereza, Marcos Flávio Montenegro, Marina Riedi Guilherme, Larissa Beatriz Volski, Juliano Camargo Rebolho
BACKGROUND: Melanoma is one of the conditions with greater increase in incidence worldwide in recent decades. It is a skin cancer with potential high lethality and predominates in Caucasian adults. Treatment of primary cutaneous melanoma is essentially surgical and search for sentinel lymph node can modify the aggressiveness of the treatment. OBJECTIVE: To analyze the epidemiological profile of patients diagnosed with primary cutaneous melanoma, histopathological features and compare with literature data...
June 2018: Anais Brasileiros de Dermatologia
Patrick S Phelan, Jamie L Mull, Mohamed Z Rajput, Amy C Musiek
We present the case of a 65-year-old man with severe headaches and unilateral facial weakness, seen in consultation by the dermatology service to rule out primary cutaneous melanoma after brain imaging identified an enlarging mass within the right trigeminal (Meckel's) cave. Examination revealed only a pair of erythematous papules on the scalp, for which biopsy demonstrated metastatic papillary thyroid carcinoma. Further evaluation and subsequent thyroidectomy confirmed the origin of widespread internal disease, followed by definitive excision of scalp lesions and multimodal management of systemic involvement...
June 17, 2018: BMJ Case Reports
Zaid Al-Qurayshi, Sudesh Srivastav, Alun Wang, Erin Boh, John Hamner, Mohamed Hassan, Emad Kandil
OBJECTIVE: In this study, we aimed to examine the association of demographic and socioeconomic factors with cutaneous melanoma that required admission. METHODS: A cross-sectional study utilizing the Nationwide Inpatient Sample database, 2003-2009, was merged with County Health Rankings Data. RESULTS: A total of 2,765 discharge -records were included. Men were more likely to have melanoma in the head, neck, and trunk regions (p < 0.001), while extremities melanoma was more common in women (p < 0...
June 18, 2018: Oncology
Klaus Griewank, Christian Koelsche, Johannes A P van de Nes, Daniel Schrimpf, Marco Gessi, Inga Möller, Antje Sucker, Richard A Scolyer, Michael E Buckland, Rajmohan Murali, Torsten Pietsch, Andreas von Deimling, Dirk Schadendorf
PURPOSE: In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria can be challenging. We aimed to assess the diagnostic and prognostic value of integrated molecular analysis. EXPERIMENTAL DESIGN: Targeted next-generation-sequencing, array-based genome-wide methylation analysis and BAP1 immunohistochemistry was performed on the largest cohort of central nervous system melanocytic tumors analyzed to date, incl...
June 11, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Özge Vural Topuz, Fatma Arzu Görtan, Zübeyde Rana Kaya Döner, Çetin Önsel, Haluk Burçak Sayman
OBJECTIVE: We investigated the utility of PET/CT in cutaneous melanoma (CM) patients with pathological negative sentinel lymph nodes (SLN), within the first year. METHODS: The results of PET/CTs and SLN biopsy (SLNB) in 65 patients (39 male and 26 female, mean age 53.8) with a PET/CT in the first postoperative year were evaluated. Within this cohort, the utility of early PET/CT imaging was assessed in patients with negative SLNB. McNemar test was used to compare PET/CT findings with SLNB results...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Siok Yen Pow, Melissa Teo
In patients with primary cutaneous melanomas of the distal upper limb, metastatic involvement of the epitrochlear lymph nodes is uncommon. It belongs to a particular category of nodal metastasis termed as interval or in-transit lymphadenopathies often encountered by tumour cells as they spread from the primary sites. We describe the case of a 41-year-old woman who presented with a right forearm melanoma that was metastatic to both the epitrochlear and axillary lymph nodes. She underwent wide excision of the primary lesion as well as epitrochlear and axillary nodal clearances in the same sitting...
June 4, 2018: BMJ Case Reports
Ines Müller, Dagmar Kulms
Malignant transformation of melanocytes, the pigment cells of human skin, causes formation of melanoma, a highly aggressive cancer with increased metastatic potential. Recently, mono-chemotherapies continue to improve by melanoma specific combination therapies with targeted kinase inhibitors. Still, metastatic melanoma remains a life-threatening disease because tumors exhibit primary resistance or develop resistance to novel therapies, thereby regaining tumorigenic capacity. In order to improve the therapeutic success of malignant melanoma, the determination of molecular mechanisms conferring resistance against conventional treatment approaches is necessary; however, it requires innovative cellular in vitro models...
May 18, 2018: Journal of Visualized Experiments: JoVE
Jonathan L Curry, Michael T Tetzlaff, Sa A Wang, Gene Landon, Nail Alouch, Sapna P Patel, Priyadharsini Nagarajan, Shiva Gupta, Phyu P Aung, Catherine E Devine, Joseph D Khoury, Sanam Loghavi, Victor G Prieto, Courtney D DiNardo, Jeffrey E Gershenwald
Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobiliary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies...
June 1, 2018: American Journal of Dermatopathology
X X Zhang, Y Fang, L B Xu, S F Xu, Z G Zhao, C Sun, P Q Ma, T Liu, S J Yu, W J Zhang
Objective: To evaluate the clinical value of preoperative (18)F-Fludeoxyglucose ((18)F-FDG PET-CT) in lymphatic metastasis diagnosis of cutaneous melanoma on extremities and trunk. Methods: 112 patients with cutaneous melanoma pathologically of extremities and trunk from January 2006 to December 2016, who received (18)F-FDG PET-CT examination preoperatively, were retrospectively reviewed. The correlations between the maximal diameters of lymph nodes, the maximal standard uptake value (SUV) and the diagnostic impression grades of PET-CT examination, and the final pathological diagnosis were analyzed...
May 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Jessica Little, Kathleen Braniff
Endometrial metastatic malignant melanoma is a rare occurrence from any primary site. A literature search has revealed only 15 reported cases in existing literature, majority of which originated from a primary cutaneous lesion. This is a case of endometrial metastasis of primary malignant melanoma of the brain, the first reported case of its kind. The rarity of endometrial metastatic melanoma may incline clinicians to neglect the importance of malignant melanoma in a patient's history when they present with abnormal uterine bleeding...
May 30, 2018: BMJ Case Reports
Andrew M Vahabzadeh-Hagh, Keith E Blackwell, Elliot Abemayor, Maie A St John
PURPOSE: Lymph node status is the single most important prognostic factor for patients with early-stage cutaneous melanoma. Sentinel lymph node biopsy (SLNB) has become the standard of care for intermediate depth melanomas. Modern SLNB implementation includes technetium-99 lymphoscintigraphy combined with local administration of a vital blue dye. However, sentinel lymph nodes may fail to localize in some cases and false-negative rates range from 0 to 34%. Here we demonstrate the feasibility of a new sentinel lymph node biopsy technique using indocyanine green (ICG) and the SPY Elite near-infrared imaging system...
May 17, 2018: American Journal of Otolaryngology
Dorota Hoja-Łukowicz, Sabina Szwed, Piotr Laidler, Anna Lityńska
Cutaneous melanoma, the most aggressive form of skin cancer, responds poorly to conventional therapy. The appearance of Tn antigen-modified proteins in cancer is correlated with metastasis and poor prognoses. The Tn determinant has been recognized as a powerful diagnostic and therapeutic target, and as an object for the development of anti-tumor vaccine strategies. This study was designed to identify Tn-carrying proteins and reveal their influence on cutaneous melanoma progression. We used a lectin-based strategy to purify Tn antigen-enriched cellular glycoproteome, the LC-MS/MS method to identify isolated glycoproteins, and the DAVID bioinformatics tool to classify the identified proteins...
May 23, 2018: Biochimie
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