keyword
MENU ▼
Read by QxMD icon Read
search

(Cutaneous metastasis) melanoma

keyword
https://www.readbyqxmd.com/read/28923671/multiple-cutaneous-in-transit-metastasis-from-cutaneous-melanoma
#1
Elena Remedios Martínez-Lorenzo, Beatriz Moreno-Torres, Alvaro Gonzalez-Cantero, Omar Palma-Ampuero, Obdulia García-Olmedo
No abstract text is available yet for this article.
September 15, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28916919/laparoscopic-liver-resection-for-metastatic-melanoma
#2
Davit L Aghayan, Airazat M Kazaryan, Åsmund Avdem Fretland, Mushegh A Sahakyan, Bård I Røsok, Bjørn Atle Bjørnbeth, Bjørn Edwin
BACKGROUND: Stage IV metastatic melanoma carries a poor prognosis. In the case of melanoma liver metastasis (MLM), surgical resection may improve survival and represents a therapeutic option, with varying levels of success. Laparoscopic liver resection (LLR) for metastatic melanoma is poorly studied. The aim of this study was to analyze the outcomes of LLR in patients with MLM. MATERIALS AND METHODS: Between April 2000 and August 2013, 11 (1 cutaneous, 9 ocular and 1 unknown primary) patients underwent LLR for MLM at Oslo University Hospital-Rikshospitalet and 13 procedures in total were carried out...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28912983/metastatic-melanoma-of-the-gallbladder-in-an-asymptomatic-patient
#3
Asad Khan, Sejal Patel, Daniel J Zaccarini, Mary McGrath
Malignant Melanoma (MM) is among the most dangerous malignancies with some of the least known survival rates. Melanoma most commonly metastasizes to regional lymph nodes, the lungs, and brain. Metastatic disease of the gallbladder (GB) is exceptionally rare making it difficult to diagnose. The fact that typically patients do not present until they are symptomatic-only after widespread metastatic disease has already occurred-is further complicating the diagnosis of MM of the GB. For this reason, MM of the GB is rarely discovered in living patients...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28891339/immunotherapy-in-managing-metastatic-melanoma-which-treatment-when
#4
Teresa Amaral, Francisco Meraz-Torres, Claus Garbe
Ten to fifteen percent of melanoma patients develop distant or unresectable metastasis requiring systemic treatment. Around 45% of the patients diagnosed with metastatic cutaneous melanoma harbor a BRAFV600 mutation and derive benefit from combined targeted therapy with MAPK pathway inhibitors. These offer a rapid response that translates into improvement of symptoms and increased quality of life. However, resistance often develops with subsequent progressive disease. Immunotherapy with checkpoint inhibitors may be offered to BRAF-mutated and wild-type patients and is associated with longer and durable responses that can continue over years...
September 9, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28888486/subungual-melanoma-management-in-the-modern-era
#5
D J Reilly, G Aksakal, R F Gilmour, D E Gyorki, A Chauhan, A Webb, M A Henderson
Subungual melanoma is a rare subtype of cutaneous melanoma that arises from the structures of the nail apparatus. It presents most commonly in older patients and at an advanced stage. A retrospective review of all patients with subungual melanoma in a single institution over a 15-year period was performed. In total, 54 patients were included (26 males, average age 62.9 years), of which 28 cases involved the upper limb. Median tumour thickness was 4.5 mm. Eighteen patients had lymph node metastasis at diagnosis, including 11 of 36 patients with positive sentinel lymph node biopsy...
August 16, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28886811/assessing-genetic-expression-profiles-in-melanoma-prognosis
#6
REVIEW
Aaron S Farberg, Alex M Glazer, Richard R Winkelmann, Darrell S Rigel
A 31-genetic expression profile (31-GEP) test (DecisionDx-Melanoma, Castle Biosciences Inc, Friendswood, TX, USA) was developed as a diagnostic test to assist physicians in the management of cutaneous malignant melanoma. Based on a patient's primary tumor expression levels of a panel of genes (28 discriminating genes and 3 control genes), a lesion is classified as "low risk" (class 1) or "high risk" (class 2) for metastasis. Studies evaluating the clinical utility and impact of the 31-GEP test showed it positively influenced clinical management and patient care, as clinicians incorporated the additional data to modify their clinical recommendations in a risk-appropriate manner...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28885538/clinical-relevance-of-18f-fdg-pet-ct-lower-limb-imaging-in-patients-with-malignant-cutaneous-melanoma
#7
Nicolas Plouznikoff, Frédéric Arsenault
OBJECTIVE: The aim of this study was to assess the clinical relevance of imaging the lower limbs when using 2-(F)-fluoro-2-deoxy-D-glucose (F-FDG) positron emission tomography with computed tomography (PET/CT) for malignant cutaneous melanoma in patients without previously known or suspected primary or metastatic melanoma lesions in the lower limbs. PATIENTS AND METHODS: We retrospectively assessed 880 consecutive F-FDG PET/CT scans performed for adult patients in a context of suspected melanoma spanning a period of 5 years...
September 6, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28877050/metformin-oxidative-and-proliferative-parameters-in-vitro-and-in-vivo-models-of-murine-melanoma
#8
Fernando P de Souza Neto, Sara S Bernardes, Poliana C Marinello, Gabriella P Melo, Rodrigo C Luiz, Rubens Cecchini, Alessandra L Cecchini
Cutaneous melanoma is one of the most lethal cancers because of its increased rate of metastasis and resistance to available therapeutic options. Early studies indicate that metformin has beneficial effects on some types of cancer, including melanoma. To clarify knowledge of the mechanism of action of metformin on this disease, two treatment-based approaches are presented using metformin on melanoma progression: an in-vitro and an in-vivo model. The in-vitro assay was performed for two experimental treatment periods (24 and 48 h) at different metformin concentrations...
September 4, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28874902/lymph-node-retrieval-rates-in-melanoma-a-quality-assessment-parameter
#9
D Berger-Richardson, E Cordeiro, M Ernjakovic, A M Easson
INTRODUCTION: Regional lymph node dissection (rlnd) for melanoma with nodal metastasis is a specialized procedure that is associated with improved disease-specific survival in selected patients. Furthermore, there is evidence that a higher lymph node retrieval rate (lnrr) is associated with improved local control. Currently, no consensus has been reached on the definition of an adequate lnrr. A minimum lnrr has been proposed as a quality assessment parameter that has to be validated. METHODS: We conducted a retrospective cohort analysis at the Princess Margaret Cancer Centre (University Health Network, Toronto, ON)...
August 2017: Current Oncology
https://www.readbyqxmd.com/read/28871923/predictive-value-of-intraoperative-sentinel-lymph-node-imprint-cytology-analysis-for-metastasis-in-patients-with-melanoma
#10
Nives Jonjić, Koraljka Rajković Molek, Irena Seili-Bekafigo, Svjetlana Grbac Ivanković, Neva Girotto, Davor Jurišić, Gordana Zamolo, Ira Pavlović Ružić, Larisa Prpić Massari
Since there are no standardized protocols regarding the detection of microscopic melanoma deposits in sentinel lymph nodes (SLN), the aim of this study was to present our experience with intraoperative cytological evaluation of SLN in patients with melanoma. The study included 475 SLN biopsies (SLNB) from 201 patients with primary cutaneous melanoma of intermediate thickness. Each lymph node was cut in half; touch imprint cytology (TIC) preparations of all cut surfaces were performed and stained according to a modified May-Grünwald-Giemsa method...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28856118/prognostic-value-of-multiple-draining-lymph-node-basins-in-melanoma-a-matched-pair-analysis-based-on-the-john-wayne-cancer-institute-experience
#11
J Harrison Howard, Junko J Ozao-Choy, Jason M Hiles, Myung-Shin Sim, Mark B Faries
BACKGROUND: The prognostic significance of multiple draining basins is controversial in melanoma because analyses have not adequately controlled for standard prognostic variables. We hypothesized that an analysis based on prognostically matched pairs of patients with multiple versus single drainage basins would clarify any independent role of basin number. STUDY DESIGN: We identified patients in our 40-year prospective database, who underwent preoperative lymphoscintigraphy, intraoperative sentinel node biopsy and wide local excision for cutaneous melanoma...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28851416/interim-analysis-of-survival-in-a-prospective-multi-center-registry-cohort-of-cutaneous-melanoma-tested-with-a-prognostic-31-gene-expression-profile-test
#12
Eddy C Hsueh, James R DeBloom, Jonathan Lee, Jeffrey J Sussman, Kyle R Covington, Brooke Middlebrook, Clare Johnson, Robert W Cook, Craig L Slingluff, Kelly M McMasters
BACKGROUND: A 31-gene expression profile (GEP) test that provides risk classification of cutaneous melanoma (CM) patients has been validated in several retrospective studies. The objective of the reported study was a prospective evaluation of the GEP performance in patients enrolled in two clinical registries. METHODS: Three-hundred twenty two CM patients enrolled in the EXPAND (NCT02355587) and INTEGRATE (NCT02355574) registries met the criteria of age ≥ 16 years, successful GEP result and ≥1 follow-up visit for inclusion in this interim analysis...
August 29, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28844540/gynecologic-melanomas-a-clinicopathologic-and-molecular-analysis
#13
Aaron M Udager, Nora K Frisch, Linda J Hong, Marina Stasenko, Carolyn M Johnston, J Rebecca Liu, May P Chan, Paul W Harms, Douglas R Fullen, Amy Orsini, Dafydd G Thomas, Lori Lowe, Rajiv M Patel
OBJECTIVE: Melanoma originating from gynecologic sites (MOGS), including the vulva, vagina, and cervix, is a rare and aggressive form of melanoma with poor long-term clinical outcome. The clinicopathologic features of vulvar and non-vulvar tumors remain relatively understudied, and in contrast to cutaneous melanomas at non-sun-exposed sites, MOGS typically do not harbor BRAF mutations. Thus, we sought to analyze the clinicopathologic and molecular features of MOGS. METHODS: A large retrospective cohort of patients with MOGS (n=59) at a single large academic institution over a 28-year period was identified...
August 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28837522/risk-factors-and-clinical-outcomes-in-patients-with-ibd-with-melanoma
#14
Loes H C Nissen, Marieke Pierik, Lauranne A A P Derikx, Elke de Jong, Wietske Kievit, Tim R A van den Heuvel, Alexander R van Rosendael, Elsemieke I Plasmeijer, Pieter Dewint, Rob H A Verhoeven, Lucy I H Overbeek, Iris D Nagtegaal, Frank Hoentjen, Andrea E van der Meulen-de Jong
BACKGROUND: Patients with inflammatory bowel disease (IBD) are at increased risk to develop malignant melanoma and this risk may increase with use of anti-tumor necrosis factor (TNF) therapy. Impaired survival of immunosuppressed melanoma patients is reported in transplant and rheumatology patients. This study aims to (1) identify risk factors for melanoma development in patients with IBD, (2) compare clinical characteristics of melanoma in patients with IBD to the general population, and (3) assess the influence of immunosuppressive medication on survival...
August 22, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28834918/endobronchial-melanoma-metastasis-40-years-after-the-excision-of-the-primary-cutaneous-tumor-a-case-report
#15
Georgia Karpathiou, Marios Froudarakis, Vanessa Da Cruz, Fabien Forest, Maxime Sauvage, Jean Michel Vergnon, Michel Peoc'h
RATIONALE: Endobronchial melanoma metastases are rare, comprising 4.5% of all endobronchial metastases. They are diagnosed at a median time of 48 months from primary tumor presentation, and survival of these patients is poorer when accompanied by other metastatic sites or malignant pleural effusion. We present a case of endobronchial melanoma metastasis happening 40 years after the initial diagnosis. The need of adjuvant techniques in the diagnosis of this tumor is highlighted and a short review on this rare phenomenon is provided...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28828681/role-of-epithelial-mesenchymal-transition-involved-molecules-in-the-progression-of-cutaneous-melanoma
#16
Daniela Murtas, Cristina Maxia, Andrea Diana, Luca Pilloni, Claudia Corda, Luigi Minerba, Sara Tomei, Franca Piras, Caterina Ferreli, Maria Teresa Perra
Epithelial-mesenchymal transition (EMT) has been suggested to have a driving role in the acquisition of a metastatic potential by melanoma cells. Important hallmarks of EMT include both E-cadherin downregulation and increased expression of N-cadherin. This switch in distinct classes of adhesion molecules leads melanoma cells to lose contact with adjacent keratinocytes and interact instead with stromal fibroblasts and endothelial cells, thus promoting dermal and vascular melanoma invasion. Consequently, tumor cells migrate to distant host tissues and establish metastases...
August 21, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28803992/p-rex1-amplification-promotes-progression-of-cutaneous-melanoma-via-the-pak1-p38-mmp-2-pathway
#17
Jinhua Wang, Hajime Hirose, Guanhua Du, Kelly Chong, Eiji Kiyohara, Isaac P Witz, Dave S B Hoon
P-REX1 (PIP3-dependent Rac exchange factor-1) is a guanine nucleotide exchange factor that activates Rac by catalyzing exchange of GDP for GTP bound to Rac. Aberrant up-regulation of P-REX1 expression has a role in metastasis however, copy number (CN) and function of P-REX1 in cutaneous melanoma are unclear. To explore the role of P-REX1 in melanoma, SNP 6.0 and Exon 1.0 ST microarrays were assessed. There was a higher CN (2.82-fold change) of P-REX1 in melanoma cells than in melanocytes, and P-REX1 expression was significantly correlated with P-REX1 CN...
October 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28800027/economic-burden-of-advanced-melanoma-in-france-germany-and-the-uk-a-retrospective-observational-study-melanoma-burden-of-illness-study
#18
Florent Grange, Peter Mohr, Mark Harries, Rainer Ehness, Laure Benjamin, Obukohwo Siakpere, Janina Barth, Ceilidh Stapelkamp, Sylvie Pfersch, Lori D McLeod, James A Kaye, Sorrel Wolowacz, Ilias Kontoudis
The aim of this study was to estimate the cost-of-illness associated with completely resected stage IIIB/IIIC melanoma with macroscopic lymph node involvement, overall and by disease phase, in France, Germany and the UK. This retrospective observational study included patients aged older than or equal to 18 years first diagnosed with stage IIIB/IIIC cutaneous melanoma between 1 January 2009 and 31 December 2011. Data were obtained from medical records and a patient survey. Direct costs, indirect costs and patient out-of-pocket expenses were estimated in euros (&OV0556;) (and British pounds, £) by collecting resource use and multiplying by country-specific unit costs...
August 10, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28783927/a-case-of-primary-small-bowel-melanoma-diagnosed-by-single-balloon-enteroscopy
#19
Jun Young Shin, In Suh Park, Byoung Wook Bang, Hyung Kil Kim, Yong Woon Shin, Kye Sook Kwon
Although metastasis from cutaneous malignant melanoma to the small intestine is not uncommon, primary small bowel melanoma (SBM) is extremely rare. This case report describes a rare case of primary SBM, diagnosed by single-balloon enteroscopy. A 74-year-old man presented with recurrent melena. Upper endoscopy and colonoscopy were unremarkable. Abdominal computed tomography (CT) revealed an ileal mass with ileo-ileal intussusception. Subsequent single-balloon enteroscopy identified an ileal tumor, which was histologically diagnosed as melanoma...
July 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28763337/folliculotropic-metastatic-melanoma-a-case-report-and-review-of-the-literature
#20
Elizabeth L McKinnon, Kelly L West, Russell A Ball, Nathan Wright, Raymond L Barnhill
Folliculotropic metastasis of cutaneous melanoma is rare, with only 5 published case reports in the English language literature since it was first described in 2009. We report a 41-year-old man with a primary cutaneous melanoma of the right upper preauricular region with metastatic spread to the parotid gland and pulmonary lymph nodes. Excision of the primary lesion was performed and immunotherapy was initiated. Sixteen months later, the patient presented with 2 new lesions of the left forehead and left neck...
September 2017: American Journal of Dermatopathology
keyword
keyword
108842
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"