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JOURNAL ARTICLE
Kuan-Cheng Chen, Tien-Hsiang Wang, Cheng-Yuan Li, Yu-Jen Chiu
BACKGROUND: Tumor staging plays a pivotal role in melanoma management, where the depth of tumor invasion has been traditionally used as the cornerstone of staging. Paradoxically, the tumor diameter has not been integrated into the staging system. The aim of this study is to elucidate the clinical implications and prognostic value of tumor diameter in cutaneous melanoma, with a particular emphasis on the acral-melanoma predominant East Asian population, thus potentially enriching the clinical evaluation and treatment strategies for cutaneous melanoma...
April 23, 2024: World Journal of Surgery
#2
Lukas Goertz, Christoph Kabbasch, Marco Timmer
We report the case of an 81-year-old patient with no pre-existing medical conditions who presented with a one-week history of progressive horizontal diplopia. Contrast-enhanced brain magnetic resonance imaging showed a heterogeneous sellar mass with the infiltration of the cavernous sinus and sella. Hormone levels were within normal limits. Considering an endocrine inactive pituitary adenoma, the patient underwent transsphenoidal resection. After surgery, the preoperative symptoms completely resolved. Histopathologic examination of the tumor specimen revealed melanoma...
March 2024: Curēus
#3
JOURNAL ARTICLE
Alessandra Buja, Massimo Rugge, Claudia Cozzolino, Francesca Dossi, Manuel Zorzi, Antonella Vecchiato, Giuseppe de Luca, Paolo Del Fiore, Saveria Tropea, Luigi dall'Olmo, Carlo Riccardo Rossi, Giovanna Boccuzzo, Simone Mocellin
A number of studies have indicated that the mitotic rate may be a predictive factor for poor prognosis in melanoma patients. The aim of this study was to investigate whether the mitotic rate is associated with other prognostic clinical and anatomopathological characteristics. After adjusting for other anatomopathological characteristics, we then verified the prognostic value of the number of mitoses, determining in which population subgroup this variable may have greater prognostic significance on 3-year mortality...
2024: PloS One
#4
JOURNAL ARTICLE
Xuejiao Liang, Jialiang Zhang, Chi Zhang, Haojie Zhai, Ping Yang, Ming Chen
We report on the fabrication of mesoporous silicon dioxide coated Haliclona sp. spicules (mSHS) to enhance the delivery of the insoluble photosensitizer protoporphyrin IX (PpIX) into deep skin layers and mediate photodynamic therapy for metastatic melanoma in mice. The mSHS are dispersed sharp edged and rod-like micro-particles with a length of approximate 143.6 ± 6.4 μm and a specific surface area of 14.9 ± 3.4 m2 /g. The mSHS can be topically applied to the skin, adapting to any desired skin area and lesion site...
April 15, 2024: Journal of Nanobiotechnology
#5
JOURNAL ARTICLE
Leyang Xiao, Ruifeng He, Kaibo Hu, Gelin Song, Shengye Han, Jitao Lin, Yixuan Chen, Deju Zhang, Wuming Wang, Yating Peng, Jing Zhang, Peng Yu
The mortality and therapeutic failure in cutaneous melanoma (CM) are mainly caused by wide metastasis and chemotherapy resistance. Meanwhile, immunotherapy is considered a crucial therapy strategy for CM patients. However, the efficiency of currently available methods and biomarkers in predicting the response of immunotherapy and prognosis of CM is limited. Programmed cell death (PCD) plays a significant role in the occurrence, development, and therapy of various malignant tumors. In this research, we integrated fourteen types of PCD, multi-omics data from TCGA-SKCM and other cohorts in GEO, and clinical CM patients to develop our analysis...
April 14, 2024: Apoptosis: An International Journal on Programmed Cell Death
#6
JOURNAL ARTICLE
Vincenzo De Giorgi, Flavia Silvestri, Giovanni Cecchi, Federico Venturi, Biancamaria Zuccaro, Gabriella Perillo, Federica Cosso, Vincenza Maio, Sara Simi, Pietro Antonini, Serena Pillozzi, Lorenzo Antonuzzo, Daniela Massi, Laura Doni
Despite being early-stage tumors, thin cutaneous melanomas contribute significantly to mortality and have a rising incidence. A retrospective case-control study was performed to identify clinical-dermoscopic and histopathological variables linked to local and distant metastases in melanomas ≤0.8 mm. Data from 1 January 2000 to 22 June 2022 were analyzed from two Italian skin cancer referral centers. Sixteen patients with ≤0.8 mm melanomas developing metastases were studied compared to controls without metastases over 5 years...
April 1, 2024: Cancers
#7
JOURNAL ARTICLE
Shantanu Srivatsa, Collin-Jamal Smith, Omar P Sangüeza, Jayson Miedema, Frances A Collichio, Paul B Googe
Melanoma with lymphatic invasion has been associated with increased risk of metastasis, but the mechanisms and clinical implications are poorly understood. Although current reports have documented angiotropic spread of melanoma and suggest lymphatic spread of melanoma to increase the likelihood of metastasis, to our knowledge, lymphangitic metastatic melanoma resembling cutaneous carcinomatosis or presenting with facial hyperpigmentation has not been described. In this case report, we describe extensive cutaneous intralymphatic spread of melanoma, or lymphangitic melanomatosis, producing macular skin pigmentation in a 66-year-old man...
April 4, 2024: American Journal of Dermatopathology
#8
JOURNAL ARTICLE
Faruk Tas
No abstract text is available yet for this article.
2024: Indian Journal of Dermatology
#9
JOURNAL ARTICLE
Jiaheng Xie, Dan Wu, Pengpeng Zhang, Songyun Zhao, Min Qi
Cutaneous melanoma poses a formidable challenge within the field of oncology, marked by its aggressive nature and capacity for metastasis. Despite extensive research uncovering numerous genetic and molecular contributors to cutaneous melanoma development, there remains a critical knowledge gap concerning the role of lipids, notably low-density lipoprotein (LDL), in this lethal skin cancer. This article endeavours to bridge this knowledge gap by delving into the intricate interplay between LDL metabolism and cutaneous melanoma, shedding light on how lipids influence tumour progression, immune responses and potential therapeutic avenues...
April 2024: Experimental Dermatology
#10
Omar Al Zarkali, Amanda Marker, Lakhvir Kaur, Ana VanDerWall
This case describes a unique presentation of a rare malignancy: giant melanoma. Due to the accessibility of healthcare in the United States, it is unusual for melanomas to grow to massive sizes without clinical intervention. In fact, an in-depth literature review elicited only a handful of similar cases. Giant malignant melanomas are typically defined by a cutoff size of no less than 10 cm in diameter. They often present with distant metastases and are highly invasive. Due to limited yet highly variable presentations, there is no standardized approach to treating this class of melanomas...
March 2024: Curēus
#11
JOURNAL ARTICLE
Takuya Nishio, Taku Maeda, Kosuke Ishikawa, Naoki Murao, Kanako Fuyama, Yuhei Yamamoto, Toshihiko Hayashi
BACKGROUND: This study aimed to clarify the relationship between primary site and lymphatic drainage pattern for malignant skin tumors in the head and neck region. Malignant melanoma and squamous cell carcinoma in the head and neck region are known to have poor prognosis because of lymph node metastasis. Nevertheless, numerous aspects of lymphatic drainage patterns remain elusive. METHODS: We statistically analyzed data of 47 patients with malignant skin tumors in the head and neck region...
March 30, 2024: International Journal of Clinical Oncology
#12
JOURNAL ARTICLE
Xue Bai, Aleigha R Lawless, Juliane A Czapla, Stefanie C Gerstberger, Benjamin C Park, Seungyeon Jung, Rebecca Johnson, Naoya Yamazaki, Dai Ogata, Yoshiyasu Umeda, Caili Li, Jun Guo, Keith T Flaherty, Yasuhiro Nakamura, Kenjiro Namikawa, Georgina V Long, Alexander M Menzies, Douglas B Johnson, Ryan J Sullivan, Genevieve M Boland, Lu Si
BACKGROUND: Anti-Program-Death-1 (PD-1) is a standard adjuvant therapy for patients with resected melanoma. We hypothesized that there are discrepancies in survival, recurrence pattern and toxicity to adjuvant PD-1 between different ethnicities and melanoma subtypes. OBJECTIVE: We performed a multicenter cohort study incorporating 6 independent institutions in Australia, China, Japan, and the United States. The primary outcomes were recurrence free survival (RFS) and overall survival (OS)...
June 2024: JAAD international
#13
REVIEW
Jinyu Wang, Zehua Li, Hongbo Yin
INTRODUCTION: Immune checkpoint inhibitors have made tremendous progress over the last decade in the treatment of cutaneous melanoma, but their application in uveal melanoma treatment is less successful, owing in part to the immunological privilege of the eye and the liver, the most frequent site of metastasis. Nevertheless, the therapeutic outcomes reported currently are less pessimistic. METHODS: In this review, we provide an overview of recent studies of immune checkpoint inhibitors in uveal melanoma and its metastasis and classify studies in this field into three groups: monotherapy of immune checkpoint inhibitors, dual-agent immune checkpoint inhibitors, and immune checkpoint inhibitors combined with other systemic or regional therapies...
March 18, 2024: Ophthalmology and Therapy
#14
JOURNAL ARTICLE
Thomas M Catapano, Rolika Bansal, Carol L Shields
No abstract text is available yet for this article.
March 14, 2024: Asia-Pacific Journal of Ophthalmology
#15
JOURNAL ARTICLE
Hyang Joo Ryu, Chayeon Kim, Hyenguk Jang, Sun Il Kim, Sang Joon Shin, Kee Yang Chung, Carlos Torres-Cabala, Sang Kyum Kim
Yes-associated protein (YAP), an effector molecule of the Hippo signaling pathway, is expressed at high levels in cutaneous melanoma. However, the role of YAP in melanoma progression according to cellular localization is poorly understood. Tissues from 140 patients with invasive melanoma were evaluated by immunohistochemistry. Flow cytometry, western blotting, viability assays, wound healing assays, verteporfin treatment, and xenograft assays were conducted using melanoma cell lines B16F1 and B16F10 subjected to YapS127A transfection and siYap knockdown...
March 14, 2024: Laboratory Investigation; a Journal of Technical Methods and Pathology
#16
JOURNAL ARTICLE
Catherine E Pisano, Megan H Trager, Weijia Fan, Faramarz H Samie
No randomized trials exist to inform the peripheral surgical margins or depth of wide excision for eyelid melanoma. We performed a meta-analysis examining surgical margins and Breslow depth for eyelid melanomas. A systematic review was performed in August 2022 using PubMed, Cochrane, and Medline databases (1/1/1990 to 8/1/2022). Inclusion criteria included studies reporting surgical treatment of primary cutaneous melanomas of the eyelid with reported surgical margins. Ten articles were included. The studies were examined by surgical margin size (group 1: ≤ 0...
March 15, 2024: Archives of Dermatological Research
#17
JOURNAL ARTICLE
Danica Tiodorovic, Jelena Stojkovic-Filipovic, Ashfaq Marghoob, Giuseppe Argenziano, Susana Puig, Josep Malvehy, Linda Tognetti, Rubegni Pietro, Bengu Nisa Akay, Iris Zalaudek, Holger A Haenssle, Christine Müller-Christmann, Elisa Cinotti, Jean Luc Perrot, Pedro Zaballos, Renato Marchiori Bakos, Luc Thomas, Ketty Peris, Aimilios Lallas, Zoe Apalla, Juergen F Kreusch, Isabelle Tromme, Alexandros J Stratigos, Maria Antonietta Pizzichetta, Lidija Kandolf, Caterina Longo, Andreas Blum, Masaru Tanaka, Rainer Hofmann-Wellenhof, Andrija Jovic, John Paoli, Marija Buljan, Martina Espasandín-Arias, Horacio Cabo, Sonia Rodrigiez Saa, Gabriel Salerni, Gianluca Nazzaro, Grazyna Kaminska-Winciorek, Giovanni Damiani, Franciska Geszti, Harald Kittler
BACKGROUND: The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. OBJECTIVES: Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. METHODS: Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs. RESULTS: We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
#18
JOURNAL ARTICLE
Hanwen Wang, Shixin Zhao, Hengdeng Liu, Yiling Liu, Zihui Zhang, Ziheng Zhou, Peng Wang, Shaohai Qi, Julin Xie
Background: N6-methyladenosine (m6 A) is the most common and abundant mRNA modification, playing an essential role in biological processes and tumor development. However, the role of m6 A methylation in skin cutaneous melanoma (SKCM) is not yet clear. This study analyzed the expression of m6 A-related functional genes in SKCM and aimed to explore the key demethylase ALKBH5 mediated m6 A modification and its potential mechanism in human SKCM. Methods: Based on public databases, the m6 A-related gene expression landscape in SKCM was portrayed...
2024: International Journal of Biological Sciences
#19
JOURNAL ARTICLE
Rakesh Banerjee, Priyadarshana Ajithkumar, Nicholas Keestra, Jim Smith, Gregory Gimenez, Euan J Rodger, Michael R Eccles, Jisha Antony, Robert J Weeks, Aniruddha Chatterjee
Cutaneous melanoma is rapidly on the rise globally, surpassing the growth rate of other cancers, with metastasis being the primary cause of death in melanoma patients. Consequently, understanding the mechanisms behind this metastatic process and exploring innovative treatments is of paramount importance. Recent research has shown promise in unravelling the role of epigenetic factors in melanoma progression to metastasis. While DNA hypermethylation at gene promoters typically suppresses gene expression, we have contributed to establishing the newly understood mechanism of paradoxical activation of genes via DNA methylation, where high methylation coincides with increased gene activity...
February 23, 2024: Cancers
#20
JOURNAL ARTICLE
Zhen-Guo Zhang, Hong-Mei Zhu, Huai-Kang Hua
OBJECTIVE: This study aimed to investigate the role of Interleukin-11 receptor alpha (IL11RA) in skin cutaneous melanoma (SKCM) metastasis to the liver. METHODS: Human SKCM cell lines (A375, A375-MA2, SK-MEL-28, RPMI-7951) and primary dermal fibroblasts (HDFa) were utilized to assess IL11RA expression. IL11RA siRNA was transfected into RPMI-7951 and A375-MA2 cells for Wound healing and Transwell invasion assays. Il11ra knockout (KO) mice and wild-type (WT) mice were injected with B16-F10 cells into the spleen to evaluate hepatic melanoma metastasis...
March 2024: Skin Research and Technology
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