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(Cutaneous metastasis) melanoma

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https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#1
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27900851/metastatic-pathways-in-patients-with-cutaneous-melanoma
#2
REVIEW
Nikki R Adler, Andrew Haydon, Catriona A McLean, John W Kelly, Victoria J Mar
Metastasis represents the end product of an elaborate biological process, which is determined by a complex interplay between metastatic tumour cells, host factors and homoeostatic mechanisms. Cutaneous melanoma can metastasize haematogenously or lymphogenously. The three predominant models that endeavour to explain the patterns of melanoma progression are the stepwise spread model, the simultaneous spread model and the model of differential spread. The time course to the development of metastases differs between the different metastatic routes...
October 19, 2016: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27836097/oral-melanoma-relevance-to-the-dental-team-members
#3
Yeshwant B Rawal, Thomas B Dodson, Harbinder S Bal
BACKGROUND AND OVERVIEW: Oral melanomas vary in color and morphology and resemble myriad other reactive, benign, or malignant conditions. The authors describe a case report of a patient with a primary oral melanoma that presented as a nonspecific ulcer, which showed nodal metastasis during resection. CASE DESCRIPTION: A 64-year-old man who was examined by his periodontist to assess implant healing had a reddish-purple ulcer of the maxillary mucosa of 3 to 4 weeks duration...
November 8, 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/27825810/dss1-promoter-hypomethylation-and-overexpression-predict-poor-prognosis-in-melanoma-and-squamous-cell-carcinoma-patients
#4
Mario Venza, Maria Visalli, Teresa Catalano, Concetta Beninati, Diana Teti, Isabella Venza
Previous studies have found a link between high expression levels of the Deleted in Split hand/Split foot 1 (DSS1) gene and cancer progression. The aim of this study was to examine whether overexpression of DSS1 is a feature of melanoma and squamous cell carcinoma (SCC) and if any epigenetic modifications are involved. Evaluation of DSS1 expression profile indicated that the gene is overexpressed in 112/130 cutaneous melanomas (86.1%), 41/64 uveal melanomas (64.1%), 67/82 mucosal melanomas (81.7%), and 61/75 SCC samples (81...
November 4, 2016: Human Pathology
https://www.readbyqxmd.com/read/27822097/the-danish-melanoma-database
#5
REVIEW
Lisbet Rosenkrantz Hölmich, Siri Klausen, Eva Spaun, Grethe Schmidt, Dorte Gad, Inge Marie Svane, Henrik Schmidt, Henrik Frank Lorentzen, Else Helene Ibfelt
AIM OF DATABASE: The aim of the database is to monitor and improve the treatment and survival of melanoma patients. STUDY POPULATION: All Danish patients with cutaneous melanoma and in situ melanomas must be registered in the Danish Melanoma Database (DMD). In 2014, 2,525 patients with invasive melanoma and 780 with in situ tumors were registered. The coverage is currently 93% compared with the Danish Pathology Register. MAIN VARIABLES: The main variables include demographic, clinical, and pathological characteristics, including Breslow's tumor thickness, ± ulceration, mitoses, and tumor-node-metastasis stage...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27813258/congenital-cutaneous-melanoma-in-a-dog
#6
Bruna Meyrer, Simone Passos Bianchi, Saulo Petinatti Pavarini, Daniel Guimarães Gerardi
BACKGROUND: Melanocytic tumours are derived from melanocytes and are common in older dogs with dark pigmented skin. Primary congenital cutaneous melanoma has been described in domestic mammals although there are no reports in the dog. HYPOTHESIS/OBJECTIVE: We describe a case of canine congenital cutaneous melanoma with rapid progression to metastasis and death. ANIMAL: A male, mixed breed dog was born with a circular ulcerated lesion near the left ear...
November 4, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27813079/the-plasma-membrane-ca-2-pump-pmca4b-inhibits-the-migratory-and-metastatic-activity-of-braf-mutant-melanoma-cells
#7
L Hegedus, T Garay, E Molnar, K Varga, A Bilecz, S Torok, R Padanyi, K Paszty, M Wolf, M Grusch, E Kallay, B Dome, W Berger, B Hegedus, A Enyedi
Oncogenic mutations of BRAF lead to constitutive ERK activity that supports melanoma cell growth and survival. While Ca(2+) signaling is a well-known regulator of tumor progression, the crosstalk between Ca(2+) signaling and the Ras-BRAF-MEK-ERK pathway is much less explored. Here we show that in BRAF mutant melanoma cells the abundance of the plasma membrane Ca(2+) ATPase isoform 4b (PMCA4b, ATP2B4) is low at baseline but markedly elevated by treatment with the mutant BRAF specific inhibitor vemurafenib. In line with these findings gene expression microarray data also shows decreased PMCA4b expression in cutaneous melanoma when compared to benign nevi...
November 4, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27778319/histological-lymphovascular-invasion-is-associated-with-nodal-involvement-recurrence-and-survival-in-patients-with-cutaneous-malignant-melanoma
#8
Faruk Tas, Kayhan Erturk
BACKGROUND: Invasion of the lymphatic or vascular vessels by the primary tumor is considered a sign of aggressive disease that leads to metastases to the regional lymph nodes and to distant sites. Although lymphovascular invasion (LVI) is one of the major characteristics of a primary melanoma tumor, its prognostic significance remains controversial. OBJECTIVE: The objective of this study was to determine the clinical significance of LVI in melanoma patients. METHODS: Outcomes in 705 patients with cutaneous melanoma were investigated retrospectively...
October 25, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27775937/bilateral-huge-incidentalomas-of-isolated-adrenal-metastases-from-unknown-primary-melanoma-revealed-by-18f-fdg-pet-ct
#9
Clément Drouet, Olivier Morel, Hatem Boulahdour
FDG PET/CT has high sensitivity and specificity for the detection of distant metastases from cutaneous melanoma. Imaging is recommended for patients with clinical suspicion of metastasis and should be considered for those with confirmed sentinel lymph node metastasis. Metastatic melanoma bears a poor prognosis. Only a complete resection improves survival, which explains the need to detect potentially unresectable disease, and most metastatic patients are ineligible for a curative surgical procedure. Here, FDG PET/CT demonstrated isolated bilateral adrenal metastases from melanoma of unknown primary...
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27774842/epidemiology-management-and-survival-outcomes-of-primary-cutaneous-melanoma-a-ten-year-overview
#10
M M F Aubuchon, L J J Bolt, M L G Janssen-Heijnen, S T H P Verleisdonk-Bolhaar, A van Marion, C L H van Berlo
BACKGROUND: Malignant melanoma (MM) is the most aggressive type of skin cancer, accounting for 90% of all the skin cancer mortality. The objective of this study was providing an overview of current patient- and tumour characteristics, treatment strategies, complications and survival in patients with MM over the past ten years. Hereby, an up-to-date view of every day clinical practice is obtained. METHODS: Files of patients treated for primary cutaneous melanoma (n = 686) in the VieCuri Medical Centre in the Netherlands between January 2002 and December 2013 were retrospectively reviewed...
October 23, 2016: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/27766186/prediction-of-positron-emission-tomography-computed-tomography-pet-ct-positivity-in-patients-with-high-risk-primary-melanoma
#11
Maria Danielsen, Andreas Kjaer, Max Wu, Lea Martineau, Mehdi Nosrati, Stanley Pl Leong, Richard W Sagebiel, James R Miller Iii, Mohammed Kashani-Sabet
Positron emission tomography/computed tomography (PET/CT) is an important tool to identify occult melanoma metastasis. To date, it is controversial which patients with primary cutaneous melanoma should have staging PET/CT. In this retrospective analysis of more than 800 consecutive patients with cutaneous melanoma, we sought to identify factors predictive of PET/CT positivity in the setting of newly-diagnosed high-risk primary melanoma to determine those patients most appropriate to undergo a PET/CT scan as part of their diagnostic work up...
2016: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27761393/mandibular-metastasis-of-cutaneous-melanoma
#12
Josi Amadeu, Cleto Mariosvaldo Piazzetta, Cassius Carvalho Torres-Pereira, José Miguel Amenábar
Melanoma is a malignant neoplasm of melanocytes that can metastasize to every organ of the body, but metastasis to the oral cavity is uncommon. We describe a case of metastatic malignant melanoma to the mandible in a 33-years-old woman. The patient had a 2 cm × 4 cm firm, ulcerated nodule, distal to the second mandibular right molar. Incisional biopsy revealed epithelioid cells and immunohistochemistry was positive for HMB-45, S-100 protein and vimentin. The patient was referred to the local cancer hospital for treatment but died 3 months later...
September 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27742175/mucosal-melanomas-in-the-racially-diverse-population-of-california
#13
Lisa Altieri, Michael K Wong, David H Peng, Myles Cockburn
BACKGROUND: Mucosal melanomas are rare, poorly understood neoplasms without a consensus standard of care. OBJECTIVE: We sought to define mucosal melanoma tumor characteristics and the racial/ethnic attributes of patients with mucosal melanomas. METHODS: We analyzed 130,920 cutaneous melanomas and 1919 mucosal melanomas recorded in the population-based California Cancer Registry from 1988 to 2013. RESULTS: Although only 1% of melanomas occurring in nonHispanic whites were mucosal, other racial/ethnic groups had a higher proportion of mucosal melanomas (15% for Asian/Pacific Islanders, 9% for nonHispanic blacks, and 4% for Hispanics)...
October 11, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27718152/differential-bmi1-twist1-snai2-mrna-expression-pattern-correlation-with-malignancy-type-in-a-spectrum-of-common-cutaneous-malignancies-basal-cell-carcinoma-squamous-cell-carcinoma-and-melanoma
#14
F Vand-Rajabpour, N Sadeghipour, S Saee-Rad, H Fathi, P Noormohammadpour, M Yaseri, K K Hesari, Z Bagherpour, M Tabrizi
PURPOSE: Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) can be used as a unique model to identify molecular mechanisms to distinguish rarely metastatic (BCC), often metastatic (SCC) and most metastatic (melanoma) cancer. It is known that epithelial-mesenchymal transition and stemness transcription factors (TWIST1, SNAI2/SLUG, and BMI1) play an important role in metastasis and their dysregulation has been demonstrated in metastatic cancers. We hypothesized that this spectrum of cutaneous cancers (BCC, SCC, and melanoma) would be a unique cancer model system to elucidate steps toward cancer invasion and metastasis...
October 7, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27717298/prolonged-survival-in-stage-iii-melanoma-with-ipilimumab-adjuvant-therapy
#15
Alexander M M Eggermont, Vanna Chiarion-Sileni, Jean-Jacques Grob, Reinhard Dummer, Jedd D Wolchok, Henrik Schmidt, Omid Hamid, Caroline Robert, Paolo A Ascierto, Jon M Richards, Céleste Lebbé, Virginia Ferraresi, Michael Smylie, Jeffrey S Weber, Michele Maio, Lars Bastholt, Laurent Mortier, Luc Thomas, Saad Tahir, Axel Hauschild, Jessica C Hassel, F Stephen Hodi, Corina Taitt, Veerle de Pril, Gaetan de Schaetzen, Stefan Suciu, Alessandro Testori
Background On the basis of data from a phase 2 trial that compared the checkpoint inhibitor ipilimumab at doses of 0.3 mg, 3 mg, and 10 mg per kilogram of body weight in patients with advanced melanoma, this phase 3 trial evaluated ipilimumab at a dose of 10 mg per kilogram in patients who had undergone complete resection of stage III melanoma. Methods After patients had undergone complete resection of stage III cutaneous melanoma, we randomly assigned them to receive ipilimumab at a dose of 10 mg per kilogram (475 patients) or placebo (476) every 3 weeks for four doses, then every 3 months for up to 3 years or until disease recurrence or an unacceptable level of toxic effects occurred...
October 7, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27706596/detecting-the-potential-cancer-association-or-metastasis-by-multi-omics-data-analysis
#16
L Hua, W Y Zheng, H Xia, P Zhou
Comprehensive multi-omics data analyses have become an important means for understanding cancer incidence and progression largely driven by the availability of high-throughput sequencing technologies for genomes, proteomes, and transcriptomes. However, how tumor cells from the site of origin of the cancer begin to grow in other sites of the body is very poorly understood. In order to examine potential connections between different cancers and to gain an insight into the metastatic process, we conducted a multi-omics data analysis using data deposited in The Cancer Genome Atlas database...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27703647/the-prognostic-value-of-age-sex-and-subsite-in-cutaneous-head-and-neck-melanoma-a-clinical-review-of-recent-literature
#17
Sameep Kadakia, David Chan, Moustafa Mourad, Yadranko Ducic
CONTEXT: Cutaneous head and neck melanoma is a challenging disease owing to its aggressive nature and often times advanced stage at presentation. Age, sex, and subsite are three prognostic indicators which can be determined prior to treatment or testing, and can allow the practitioner to counsel the patient before initiating therapy. EVIDENCE ACQUISITION: A PubMed search was conducted utilizing various terms relating to the subject matter. Articles over the past 25 years were analyzed and appropriately selected for review...
June 2016: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/27672418/fully-regressive-melanoma-a-case-without-metastasis
#18
Eric Ehrsam, Joseph R Kallini, Damien Lebas, Amor Khachemoune, Philippe Modiano, Hervé Cotten
Fully regressive melanoma is a phenomenon in which the primary cutaneous melanoma becomes completely replaced by fibrotic components as a result of host immune response. Although 10 to 35 percent of cases of cutaneous melanomas may partially regress, fully regressive melanoma is very rare; only 47 cases have been reported in the literature to date. AH of the cases of fully regressive melanoma reported in the literature were diagnosed in conjunction with metastasis on a patient. The authors describe a case of fully regressive melanoma without any metastases at the time of its diagnosis...
August 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27666765/clinical-significance-of-braf-v600e-mutational-status-in-capsular-nevi-of-sentinel-lymph-nodes-in-patients-with-primary-cutaneous-melanoma
#19
Alan E Siroy, Phyu P Aung, Carlos A Torres-Cabala, Michael T Tetzlaff, Priyadharsini Nagarajan, Denái R Milton, Jonathan L Curry, Doina Ivan, Victor G Prieto
Capsular nevi (CN) are clusters of benign melanocytes situated in the capsule of lymph nodes and occur in up to 20% of lympadenectomy specimens. The molecular profile of CN in relation to prognostic parameters in primary cutaneous melanoma (PCM) patients has not been previously investigated. We assessed BRAF V600E mutation by IHC in the CN of sentinel lymph nodes (SLN) in PCM patients and correlated the findings with demographic characteristics, PCM histopathologic and molecular features, and clinical outcome parameters...
September 22, 2016: Human Pathology
https://www.readbyqxmd.com/read/27666747/availability-of-sentinel-lymph-node-biopsy-for-cutaneous-squamous-cell-carcinoma
#20
Hiroshi Maruyama, Ryota Tanaka, Yasuhiro Fujisawa, Yasuhiro Nakamura, Shusaku Ito, Manabu Fujimoto
Cutaneous squamous cell carcinoma is the second common cutaneous cancer, especially in the elderly. Sentinel lymph node biopsy is generally performed in breast cancers and cutaneous melanomas to detect occult nodal metastases. The benefit of sentinel lymph node biopsy in improving cutaneous squamous cell carcinoma prognosis is doubtful. One hundred and sixty-nine patients who underwent treatment for cutaneous squamous cell carcinoma between 2004 and 2015, and who were followed up for at least 6 months or developed metastases within the follow-up period were included...
September 26, 2016: Journal of Dermatology
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