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(Cutaneous metastasis) melanoma

Oana-Diana Persa, Jana Knuever, Anna Rose, Cornelia Mauch, Max Schlaak
BACKGROUND: Sentinel lymph node biopsy (SLNB) is currently a routine procedure in the staging of patients with cutaneous melanoma; however, little information is available about the risk factors for postoperative complications, especially for the risk of seroma formation. METHODS: Medical records of patients undergoing SLNB at the University Hospital of Cologne, Germany, between 2011 and 2016, were reviewed. Binary logistic regression was used to analyze the influence of a wide range of variables on seroma development...
September 19, 2018: International Journal of Dermatology
Daniel E Oliver, Vernon K Sondak, Tobin Strom, Jonathan S Zager, Arash O Naghavi, Amod Sarnaik, Jane L Messina, Jimmy J Caudell, Andy M Trotti, Javier F Torres-Roca, Nikhil I Khushalani, Louis B Harrison
Aim: We assessed the role of adjuvant interferon on relapse-free survival (RFS), distant metastasis-free survival (DMFS) and overall survival (OS) in node-positive melanoma patients. Methods: We retrospectively reviewed 385 node-positive patients without distant metastatic disease treated from 1998 to 2015. The surgery was therapeutic lymph node dissection (LND, n = 86) or sentinel lymph node biopsy ± completion LND (n = 270). 128 patients (33.2%) received adjuvant interferon...
June 2018: Melanoma Management
Irappa Madabhavi, Nagaveni Kadakol, Chidanand Chavan, Malay Sarkar
Skin metastases from colorectal carcinoma are rare and signal advanced disease. Skin metastasis refers to growth of cancer cells in the skin originating from an internal cancer. In most cases, cutaneous metastasis develops after the initial diagnosis of the primary internal malignancy and late in the course of the disease. In very rare cases, skin metastasis may occur at the same time or before the primary cancer has been discovered and may be the prompt for further thorough investigation. The incidence of skin metastasis varies but is somewhere between 3-10% in patients with a primary malignant tumor...
July 2018: Middle East Journal of Digestive Diseases
A Saad Abdalla, Anita Lazarevska, Mohammed Murwan Omer, Elizabeth Tan, Amira Asaad, Sharlini Sathananthan
The most common sites of invasive breast cancer metastasis are the lungs, liver, bones and brain. Less frequent sites include the gastrointestinal tract, pancreas, spleen, thyroid, adrenals, kidneys, heart and female genital tract. The uterus is reported as a rare site for metastasis, and even more so for an isolated metastasis. Other sites of extra-genital sources for uterine metastases include the colon, stomach, pancreas, gallbladder, lung, cutaneous melanoma, urinary bladder and thyroid. The rarity of breast cancer metastasis to the uterine cervix could be explained by the fact that the cervix has a small blood supply and an afferent lymph drainage system alone...
July 2018: Chirurgia
F Tas, K Erturk
BACKGROUND: The differences in features and risk factors for recurrence after definitive surgical excision are yet to be determined. The aim of this study was to understand these factors influencing recurrence patterns with local and regional disease in these patients. METHODS: A total of 365 relapsed patients, of whom 196 presented with local disease (stage I-II) and 169 with regional disease (stage III), were investigated in this retrospective study. RESULTS: The median time to initial recurrence for stage I-II and stage III patients was 22...
September 4, 2018: Clinical & Translational Oncology
Anthony Nye, Justin D Collins, Caroline L Porter, Mary Montes de Oca, Kathryn George, Colin G Stafford, Christine M G Schammel, Samuel Horton, Steven D Trocha
Melanoma confers an estimated lifetime risk of one in 50 for 2016. Clinicopathologic staging and sentinel lymph node biopsy (SLNB) have been the standard of care for T2 and T3 lesions. Molecular biomarkers identified in the primary lesion suggestive of metastatic potential may offer a more conclusive prognosis of these lesions. Our purpose was to investigate molecular mutations in primary melanoma that were predictive for micrometastasis as defined by a positive sentinel lymph node (SLN) in a case-controlled manner: nine patients with negative SLN and nine with positive SLN...
September 1, 2018: Melanoma Research
Pēteris Alberts, Andra Tilgase, Agnija Rasa, Katrīna Bandere, Dite Venskus
Oncolytic viruses are a fast-developing cancer treatment field. Numerous viruses have been tested in clinical trials and three are approved. The first, Rigvir, is an immunomodulator with anti-tumour effect for treatment of melanoma, local treatment of skin and subcutaneous metastases of melanoma, for prevention of relapse and metastasis after radical surgery registered in Latvia, Georgia, Armenia and Uzbekistan. The aim of the present review is to summarize the development of Rigvir. Approximately 60 viruses were screened preclinically...
September 1, 2018: European Journal of Pharmacology
Faruk Tas, Kayhan Erturk
BACKGROUND: Melanomas arising from eyelid skin are exceptionally rare, accounting for <1% of eyelid malignancies and all cutaneous melanomas. The aim of this study was to identify the histopathological features and clinical behaviors of the palpebral skin melanoma patients from a single tertiary institution. PATIENTS AND METHODS: Seventeen Caucasian patients diagnosed with eyelid cutaneous melanoma were analyzed retrospectively. RESULTS: The median age of patients was 59 years, and females were predominant (n = 11)...
August 31, 2018: International Journal of Dermatology
Sohail Farshad, Scott Keeney, Alexandra Halalau, Gehad Ghaith
Melanoma is the most common cancer to metastasize to the gastrointestinal tract; however, metastasis to the stomach is a rare occurrence. We present the case of a patient with a history of melanoma of the chest wall 15 years prior to presentation who initially presented to the hospital with sepsis but was later found to have metastatic melanoma in the gastric cardia. This case illustrates the rare occurrence of metastatic melanoma to the stomach which occurred 15 years after the initial skin diagnosis of melanoma was made, its endoscopic appearance, and how the nonspecific symptoms frequently lead to a delayed diagnosis or one that is not made at all until after autopsy...
2018: Case Reports in Gastrointestinal Medicine
Jerry A Shields, Carol L Shields, Sara E Lally, Tatyana Milman, Ralph C Eagle
An 8-year-old girl was referred for an amelanotic iris tumor believed to have enlarged slightly over 3 months, suspicious for juvenile xanthogranuloma (JXG). The affected right eye had a lightly pigmented, vascular iris mass measuring 6 mm in basal dimension and 2 mm in thickness. There were no feeder vessels, seeding, inflammatory cells, or cutaneous abnormalities. Diagnostic fine needle aspiration biopsy (FNAB) was performed, revealing spindle B melanoma cells that were immunoreactive for melanocytic markers HMB45 and Melan-A...
April 2018: Middle East African Journal of Ophthalmology
Carol L Shields, R Joel Welch, Kunal Malik, Luis A Acaba-Berrocal, Evan B Selzer, Jennifer H Newman, Eileen L Mayro, Alexandru B Constantinescu, Meredith A Spencer, Mark P McGarrey, Austen N Knapp, Alexander E Graf, Alex J Altman, Sean P Considine, Jerry A Shields
PURPOSE: The purpose of this study is to evaluate patients with uveal metastasis based on primary tumor site. METHODS: Retrospective analysis from Wills Eye Hospital, Philadelphia, PA, USA, for uveal metastasis clinical features and outcomes based on the primary tumor site. RESULTS: There were 2214 uveal metastases diagnosed in 1111 consecutive patients. The demographics included mean age of 60 years (median 61 years), Caucasian race (88%), and female gender (64%)...
April 2018: Middle East African Journal of Ophthalmology
Shi Yang, Dominick A Leone, Asok Biswas, April Deng, Drazen Jukic, Rajendra Singh, Uma Sundram, Meera Mahalingam
Despite the efficacy of BRAF-targeted and PD-L1-related immune therapies in tackling metastatic melanoma, a significant number of patients exhibit resistance. Given this, the objective of the current study was to ascertain concordance of somatic mutations in BRAF/ NRAS/TERT and, immunohistochemical PD-L1 and CD8 in matched primary cutaneous and metastatic melanoma. A total of 43 archival paired samples with sufficient material for genetic and immunohistochemical analyses met criteria for inclusion in the study...
August 15, 2018: Human Pathology
Yiju Lee, Weifeng Yao, Chunjun Yang, Yunrui Li, Haiyang Ni, Lei Wang, Bin Ji, Yongge Gu, Sen Yang
Cutaneous malignant melanoma (CMM) is one of the most dangerous types of skin cancer. The prognosis of CMM patients with ulcers, regional lymph node metastasis or organ metastasis is poor. In this process, resistance to anoikis is a critical step in tumor cell metastasis. Tumor cells survive in the vascular and lymphatic system through the escape of anoikis to finally form clones in the distal tissue. The present study revealed that muscle intestine and stomach expression 1 (MIST1), a secreting cell-restricted transcription factor, was overexpressed in melanoma cells...
August 2018: Experimental and Therapeutic Medicine
Anne K Maxwell, Hiroki Takeda, Samuel P Gubbels
OBJECTIVE: To present a case of primary middle ear mucosal melanoma and perform a comprehensive literature review of middle ear and eustachian tube mucosal melanoma. PATIENT: A 61-year-old female presented with no prior history of melanoma and 3 months of aural fullness. A middle ear mass demonstrated primary mucosal melanoma. The mass extended from mesotympanum into hypotympanum, epitympanum, protympanum, eustachian tube, and mastoid antrum. Additionally, a nonenhancing expansile lesion of the petrous apex was noted on magnetic resonance imaging...
August 13, 2018: Annals of Otology, Rhinology, and Laryngology
Alessandro Mantovani, Ilaria Teobaldi, Vincenzo Stoico, Fabrizia Perrone, Marina Zannoni, Luca Cima, Massimiliano Bruti, Lucia Mingolla, Maddalena Trombetta, Enzo Bonora
After basal cell carcinoma, the cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer worldwide, and, classically, arises from the upper coats of the epidermis of sun-exposed areas or from skin areas constantly exposed to a chronic inflammatory stimulus. The occurrence of cSCC seems to be linked to several factors, including exposure to sunlight (or other ultraviolet radiations), immunosuppression, chronic scarring conditions and some familial cancer syndromes. Although the majority of cSCCs are adequately eradicated by surgical excision, a subgroup of cSCC may be linked with an increased risk of recurrence, metastasis and death...
2018: Endocrinology, Diabetes & Metabolism Case Reports
Brian R Gastman, Pedram Gerami, Sarah J Kurley, Robert W Cook, Sancy Leachman, John T Vetto
BACKGROUND: A substantial number of patients who relapse and die from cutaneous melanoma (CM) are categorized as low-risk by traditional staging factors. The 31-gene expression profile (31-GEP) test independently stratifies metastatic risk for CM patients as low (Class 1; 1A lowest risk) or high (Class 2; 2B highest risk). OBJECTIVE: To assess risk prediction by a 31-GEP test within three American Joint Committee on Cancer low-risk CM populations: sentinel lymph node (SLN)-negative, stage I-IIA, or thin (≤1mm, T1) tumors...
August 3, 2018: Journal of the American Academy of Dermatology
Daniel Eiger, Daniel Arcuschin de Oliveira, Renato Leão de Oliveira, Murilo Costa Sousa, Mireille Darc Cavalcante Brandão, Renato Santos de Oliveira Filho
Cutaneous melanoma is the solid neoplasia with the highest growing incidence among all tumors. It spreads predictably to the lymphatic vessels and sentinel lymph node, and when the latter is affected the prognosis worsens dramatically. Sentinel lymph node biopsy is considered when thickness of the primary tumor exceeds 1mm and/or when there are adverse features in thinner melanomas. When there is nodal metastasis, current evidence in the literature recommends complete lymphadenectomy, although this procedure has its intrinsic risks (i...
July 2018: Anais Brasileiros de Dermatologia
Anthony Noor, Andrew Cheng, Paul Sambrook, Alastair Goss
Background: Malignant melanoma is an aggressive and unpredictable cancer with the propensity for widespread metastasis. Whilst metastatic spread to the axial skeleton is relatively common, metastasis to the jaws is rarely reported and the optimal approach to investigation and management is yet to be defined. Case presentation: A 58-year-old woman presented with dental pain, swelling and mental neuropathy on a background of an excised cutaneous melanoma. Early radiological investigations showed non-specific osteolysis despite strong clinical findings...
September 2018: Journal of Maxillofacial and Oral Surgery
P G Corrie, A Marshall, P D Nathan, P Lorigan, M Gore, S Tahir, G Faust, C G Kelly, M Marples, S J Danson, E Marshall, S J Houston, R E Board, A M Waterston, J P Nobes, M Harries, S Kumar, A Goodman, A Dalgleish, A Martin-Clavijo, S Westwell, R Casasola, D Chao, A Maraveyas, P M Patel, C H Ottensmeier, D Farrugia, A Humphreys, B Eccles, G Young, E O Barker, C Harman, M Weiss, K A Myers, A Chhabra, S H Rodwell, J A Dunn, M R Middleton
Background: Bevacizumab is a recombinant humanised monoclonal antibody to vascular endothelial growth factor shown to improve survival in advanced solid cancers. We evaluated the role of adjuvant bevacizumab in melanoma patients at high risk of recurrence. Patients and methods: Patients with resected AJCC stage IIB, IIC and III cutaneous melanoma were randomised to receive either adjuvant bevacizumab (7.5 mg/kg i.v. 3 weekly for 1 year) or standard observation...
August 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Agnes Forsthuber, Katharina Lipp, Liisa Andersen, Stefanie Ebersberger, Osvaldo Graña-Castro, Wilfried Ellmeier, Peter Petzelbauer, Beate M Lichtenberger, Robert Loewe
Chemokines mold the tumor microenvironment by recruiting distinct immune cell populations, thereby strongly influencing disease progression. Previously, we showed that CXCL5 expression is upregulated in advanced stages of primary melanomas, which correlates with the presence of neutrophils in the tumor. Analysis of neutrophil populations in various tissues revealed a distinct phenotype of tumor associated neutrophils (TANs). TANs expressed PD-L1, CXCR4, CCR5, Adam17, Nos2 and were immunosuppressive in a T cell proliferation assay...
July 13, 2018: Journal of Investigative Dermatology
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