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'Therapeutic ultrasound'

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https://www.readbyqxmd.com/read/29205374/ethyl-chloride-spray-for-musculoskeletal-ultrasound-guided-injections-an-alternative-to-subcutaneous-injection-of-local-anesthetic-solution
#1
Amit Shah, Alessandro Vidoni, Sharon McGarry, Mark Davies, Steven James, Rajesh Botchu
Ultrasound-guided injections such as steroid injections are common procedures involving the musculoskeletal system. They are usually performed after a subcutaneous injection of local anesthetic (LA), which can be painful. In 126 consecutive patients, local anesthesia was performed using ethyl chloride spray prior to a therapeutic ultrasound-guided injection in joints, tendons, or bursae. Ninety-nine (78.5%) patients found the use of ethyl chloride spray helpful. The use of ethyl chloride spray is an effective, patient-friendly alternative to the standard injection of local aesthetic for ultrasound-guided therapeutic musculoskeletal injections with the advantage of a lower cost of $0...
December 4, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29195473/clustering-dynamics-of-microbubbles-exposed-to-low-pressure-1-mhz-ultrasound
#2
Carole Lazarus, Antonios N Pouliopoulos, Marc Tinguely, Valeria Garbin, James J Choi
Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50-100 kPa and a pulse length of 20 ms...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29132387/theoretically-proposed-optimal-frequency-for-ultrasound-induced-cartilage-restoration
#3
April D Miller, Anuradha Subramanian, Hendrik J Viljoen
BACKGROUND: Matching the frequency of the driving force to that of the system's natural frequency of vibration results in greater amplitude response. Thus we hypothesize that applying ultrasound at the chondrocyte's resonant frequency will result in greater deformation than applying similar ultrasound power at a frequency outside of the resonant bandwidth. Based on this resonant hypothesis, our group previously confirmed theoretically and experimentally that ultrasound stimulation of suspended chondrocytes at resonance (5 MHz) maximized gene expression of load inducible genes...
November 14, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#4
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes A S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
November 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29122255/the-medium-term-effects-of-diadynamic-currents-in-chronic-low-back-pain-tens-versus-diadynamic-currents-a-randomised-follow-up-study
#5
Selcuk Sayilir, Mustafa Turgut Yildizgoren
OBJECTIVE: The aims of the study were to evaluate the medium-term effects of diadynamic (DD) currents on relieving symptoms/improving physical functionality in patients with chronic low back pain (LBP) and to compare the efficacy of DD versus TENS. METHODS: The patients were divided into two groups as the TENS group (n = 26) and the DD group (n = 29). Additional treatment of hot pack + therapeutic ultrasound was applied to all patients. The therapy programs were administered as a total of 10 sessions over a period of 2 weeks...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29118380/delivery-of-the-gene-encoding-the-tumor-suppressor-sef-into-prostate-tumors-by-therapeutic-ultrasound-inhibits-both-tumor-angiogenesis-and-growth
#6
Sabrin Mishel, Boris Shneyer, Lina Korsensky, Orit Goldshmidt-Tran, Tom Haber, Marcelle Machluf, Dina Ron
Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinomas, in a manner correlating with tumor aggressiveness. In vitro, hSef-b inhibited proliferation of TRAMP C2 cells and attenuated activation of ERK/MAPK and the master transcription factor NF-κB in response to FGF and IL-1/TNF, respectively...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096999/interstitial-matrix-prevents-therapeutic-ultrasound-from-causing-inertial-cavitation-in-tumescent-subcutaneous-tissue
#7
John P Koulakis, Joshua Rouch, Nhan Huynh, Genia Dubrovsky, James C Y Dunn, Seth Putterman
We search for cavitation in tumescent subcutaneous tissue of a live pig under application of pulsed, 1-MHz ultrasound at 8 W cm(-2) spatial peak and pulse-averaged intensity. We find no evidence of broadband acoustic emission indicative of inertial cavitation. These acoustic parameters are representative of those used in external-ultrasound-assisted lipoplasty and in physical therapy and our null result brings into question the role of cavitation in those applications. A comparison of broadband acoustic emission from a suspension of ultrasound contrast agent in bulk water with a suspension injected subcutaneously indicates that the interstitial matrix suppresses cavitation and provides an additional mechanism behind the apparent lack of in-vivo cavitation to supplement the absence of nuclei explanation offered in the literature...
October 31, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29066019/assessment-of-coded-excitation-implementation-for-estimating-heat-induced-speed-of-sound-changes
#8
Oren Gargir, Haim Azhari, Michael Zibulevsky
Speed of sound (SoS) is an acoustic property that is highly sensitive to changes in tissues. SoS can be mapped non-invasively using ultrasonic through transmission wave tomography. This however, practically limits its clinical use to the breast. A pulse-echo-based method that has broader clinical use and that can reliably measure treatment-induced changes in SoS even under poor signal-to-noise ratio (SNR) is highly desirable. The aim of this study was to evaluate the implementation of coded excitations (CoEs) to improve pulse-echo monitoring of heat-induced changes in the SoS...
October 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28979692/therapeutic-ultrasound-plus-pulsed-electromagnetic-field-improves-recovery-from-peripheral-arterial-disease-in-hypertension
#9
Zhao-Yang Lu, Hong-Sheng Zhou, Zhi-Xiao Su, Jia Qi, Jian Zhang, Guan-Hua Xue, Yue Li, Chang-Ning Hao, Yi-Qin Shi, Jun-Li Duan
The objective of this investigation was to evaluate the therapy effect of combined therapeutic ultrasound (TUS) treatment and pulsed electromagnetic field (PEMF) therapy on angiogenesis in hypertension-related hindlimb ischemia. After subjecting excision of the left femoral artery, spontaneously hypertensive rats (SHRs) were randomly distributed to one of four groups: SHR; TUS treated SHR (SHR-TUS); PEMF treated SHR (PEMF-TUS); and TUS plus PEMF treated SHR (SHR-TUS-PEMF). Wistar-Kyoto rats (WKYs) with femoral artery excision were regarded as a control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28968232/the-effect-of-kinesio%C3%A2-taping-on-pain-functionality-mobility-and-endurance-in-the-treatment-of-chronic-low-back-pain-a-randomized-controlled-study
#10
Fahri Köroğlu, Tuğba Kuru Çolak, M Gülden Polat
BACKGROUND: Low back pain is one of the most important causes of morbidity. OBJECTIVE: This study was designed to evaluate the effect of Kinesio® taping on pain, functionality, mobility and endurance in chronic low back pain treatment. METHODS: Patients with chronic low back pain were randomly divided into three groups. Therapeutic ultrasound, hot packs, and transcutaneous electrical nerve stimulation were applied to each group for ten sessions during two weeks, and therapeutic exercises were applied in the clinic under physiotherapist supervision starting from the sixth session...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28932004/effects-of-pulsed-therapeutic-ultrasound-on-the-treatment-of-people-with-knee-osteoarthritis
#11
Eliana-Isabel Rodríguez-Grande, Jose-Luis Osma-Rueda, Yannely Serrano-Villar, Carolina Ramírez
[Purpose] The aim was to evaluate the effect of therapeutic ultrasound on the pain, joint mobility, muscle strength, physical function, and quality of life of people with knee OA. [Subjects and Methods] One-site, one-arm, before-after study that included people with Grade II or III tibiofemoral osteoarthritis. Ten therapeutic ultrasound sessions (duty cycle=20%, ERA=10 cm(2), BNR=6:1, SATP=2.2 W/cm(2), SATA=0.44 W/cm(2), frequency=1 MHz, time=4 minutes) were applied. Assessments of primary outcome variables: pain intensity and function, and secondary variables: joint mobility, muscle strength and quality of life, were performed at onset and end of therapy; an additional intermediate evaluation was included for the primary variables...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929267/increasing-distribution-of-drugs-released-from-in-situ-forming-plga-implants-using-therapeutic-ultrasound
#12
Chawan Manaspon, Christopher Hernandez, Pinunta Nittayacharn, Selva Jeganathan, Norased Nasongkla, Agata A Exner
One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2...
December 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28900624/ultrasound-mediated-microbubbles-destruction-augmented-sonolysis-an-in-vitro-and-in-vivo-study
#13
Hai Cui, Qiong Zhu, Yunhua Gao, Hongmei Xia, Kaibin Tan, Ying He, Zheng Liu, Yali Xu
OBJECTIVE: This study was aimed at exploring ultrasound mediated microbubbles destruction (UMMD) assisted sonolysis in both the in vitro and in vivo clots. METHODS: Therapeutic ultrasound (TUS) and lipid microbubbles (MBs) were used in whole blood clots and divided into the control, TUS group, and TUS + MB group. Thrombolytic rates and microscopy were performed. Color Doppler flow imaging (CDFI) and angiography were performed to evaluate the recanalization rates and flow scores in femoral arterial thrombus (FAT) in rabbits...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28844602/further-investigation-on-high-intensity-focused-ultrasound-hifu-treatment-for-thyroid-nodules-effectiveness-related-to-baseline-volumes
#14
Michael Sennert, Christian Happel, Yücel Korkusuz, Frank Grünwald, Björn Polenz, Daniel Gröner
RATIONALE AND OBJECTIVES: Several minimally invasive thermal techniques have been developed for the treatment of benign thyroid nodules. A new technique for this indication is high-intensity focused ultrasound (HIFU). The aim of this study was to assess effectiveness in varying preablative nodule volumes and whether outcome patterns that were reported during studies with other thermal ablative procedures for thyroid nodule ablation would also apply to HIFU. MATERIALS AND METHODS: Over the last 2 years, 19 nodules in 15 patients (12 women) whose average age was 58...
August 23, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28833460/genomic-damage-induced-by-1-mhz-ultrasound-in-vitro
#15
Ion Udroiu, Jessica Marinaccio, Angelico Bedini, Claudia Giliberti, Raffaele Palomba, Antonella Sgura
Genotoxic effects of therapeutic ultrasound are poorly documented, when compared with the wide use of this physical agent. The aim of this work was to investigate the clastogenic and aneugenic potential of 1 MHz ultrasound, employing intensities (200 and 300 mW/cm(2) ) above the cavitational threshold, but in the range of those normally used in therapeutics. Both normal fibroblasts (AG01522) and tumoral cells (MCF-7) were sonicated. While no effects on viability were noted, significant increases of CREST-negative micronuclei (indicative of clastogenesis) and CREST-positive micronuclei (indicative of aneuploidy) were detected...
August 19, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28776612/overcoming-t-gondii-infection-and-intracellular-protein-nanocapsules-as-biomaterials-for-ultrasonically-controlled-drug-release
#16
REVIEW
M S Aw, L Paniwnyk
One of the pivotal matters of concern in intracellular drug delivery is the preparation of biomaterials containing drugs that are compatible with the host target. Nanocapsules for oral delivery are found to be suitable candidates for targeting Toxoplasma gondii (T. gondii), a maneuvering and smart protozoic parasite found across Europe and America that causes a subtle but deadly infection. To overcome this disease, there is much potential of integrating protein-based cells into bioinspired nanocompartments such as via biodegradable cross-linked disulfide polyelectrolyte nanoparticles...
September 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28766896/novel-cranial-implants-of-yttria-stabilized-zirconia-as-acoustic-windows-for-ultrasonic-brain-therapy
#17
Mario I Gutierrez, Elias H Penilla, Lorenzo Leija, Arturo Vera, Javier E Garay, Guillermo Aguilar
Therapeutic ultrasound can induce changes in tissues by means of thermal and nonthermal effects. It is proposed for treatment of some brain pathologies such as Alzheimer's, Parkinson's, Huntington's diseases, and cancer. However, cranium highly absorbs ultrasound reducing transmission efficiency. There are clinical applications of transcranial focused ultrasound and implantable ultrasound transducers proposed to address this problem. In this paper, biocompatible materials are proposed for replacing part of the cranium (cranial implants) based on low porosity polycrystalline 8 mol% yttria-stabilized-zirconia (8YSZ) ceramics as acoustic windows for brain therapy...
August 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28753417/ex-vivo-determined-experimental-correction-factor-for-the-ultrasonic-source-term-in-the-bioheat-equation
#18
Guillermo A Cortela, Wagner C A Pereira, Carlos A Negreira
The objective of this work is to propose an effective absorption coefficient (αeffec) as an empirical correction factor in the source term of the bioheat equation. The temperature rise in biological tissue due to ultrasound insonification is produced by energy absorption. Usually, the ultrasonic absorption coefficient (αA) is used as a source term in the bioheat equation to quantify the temperature rise, and the effect of scattering is disregarded. The coefficient αeffec includes the scattering contribution as an additional absorption term and should allow us to make a better estimation of the thermal dose (TD), which is important for clinical applications...
January 2018: Ultrasonics
https://www.readbyqxmd.com/read/28739379/ultrasound-induced-bubble-clusters-in-tissue-mimicking-agar%C3%A2-phantoms
#19
Pooya Movahed, Wayne Kreider, Adam D Maxwell, Barbrina Dunmire, Jonathan B Freund
Therapeutic ultrasound can drive bubble activity that damages soft tissues. To study the potential mechanisms of such injury, transparent agar tissue-mimicking phantoms were subjected to multiple pressure wave bursts of the kind being considered specifically for burst wave lithotripsy. A high-speed camera recorded bubble activity during each pulse. Various agar concentrations were used to alter the phantom's mechanical properties, especially its stiffness, which was varied by a factor of 3.5. However, the maximum observed bubble radius was insensitive to stiffness...
October 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28738698/implementation-and-evaluation-of-a-rehabilitation-concept-in-a-patient-suffering-from-scleredema-adultorum-buschke-a-case-report
#20
Michael Mickel, Ahmad Jalili, Christina Gesslbauer, Richard Crevenna
PURPOSE: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. METHODS: A treatment plan was developed containing therapeutic ultrasound, manual lymphatic drainage, and physiotherapy...
July 24, 2017: Disability and Rehabilitation
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