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'Therapeutic ultrasound'

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https://www.readbyqxmd.com/read/29451124/copper-oxide-loaded-plga-nanospheres-towards-a-multifunctional-nanoscale-platform-for-ultrasound-based-imaging-and-therapy
#1
Or Perlman, Iris S Weitz, Sarit Sivan, Hiba Abu-Khalla, Madeleine Benguigui, Yuval Shaked, Haim Azhari
Copper oxide nanoparticles (CuO-NPs) are increasingly investigated for diagnostic and therapeutic purposes. Recent work have demonstrated their anticancer potential as well as contrast agent capabilities for magnetic resonance imaging (MRI) and through-transmission ultrasound. However, no capabilities of CuO-NPS were demonstrated using conventional ultrasound systems, which, unlike the formers, are widely deployed in the clinic. Furthermore, in spite of their potential as multifunctional nano-based materials for diagnosis and therapy, CuO-NPs were delayed from further clinical translation due to their inherent toxicity...
February 16, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29406415/magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-applications-in-pediatrics-early-experience-at-children-s-national-medical-center
#2
Karun V Sharma, Pavel S Yarmolenko, Avinash Eranki, Ari Partanen, Haydar Celik, AeRang Kim, Matthew Oetgen, Peter C W Kim
Magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) is a novel technology that integrates magnetic resonance imaging with therapeutic ultrasound. This unique approach provides a completely noninvasive method for precise thermal ablation of targeted tissues with real-time imaging feedback. Over the past 2 decades, MR-HIFU has shown clinical success in several adult applications ranging from treatment of painful bone metastases to uterine fibroids to prostate cancer and essential tremor...
February 2018: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/29389657/diffraction-effects-and-compensation-in-passive-acoustic-mapping
#3
Michael D Gray, Erasmia Lyka, Constantin C Coussios
Over the last decade, a variety of noninvasive techniques have been developed to monitor therapeutic ultrasound procedures in support of safety or efficacy assessments. One class of methods employs diagnostic ultrasound arrays to sense acoustic emissions, thereby providing a means to passively detect, localize, and quantify the strength of nonlinear sources, including cavitation. Real array element diffraction patterns may differ substantially from those presumed in existing beamforming algorithms. However, diffraction compensation has received limited treatment in passive and active imaging, and measured diffraction data have yet to be used for array response correction...
February 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29373113/comparison-of-the-effects-of-1mhz-and-3mhz-therapeutic-ultrasound-on-endothelium-dependent-vasodilation-of-humans-a-randomised-clinical-trial
#4
M Hauck, C Noronha Martins, M Borges Moraes, P Aikawa, F da Silva Paulitsch, R Della Méa Plentz, S Teixeira da Costa, A M Vargas da Silva, L U Signori
OBJECTIVE: To compare the effects of different waveforms of 1MHz and 3MHz therapeutic ultrasound on endothelial function in healthy subjects. DESIGN: Randomised placebo-controlled, crossover study with concealed allocation and assessor blinding. SETTING: Imaging Centre of the University Hospital. PARTICIPANTS: Thirty volunteers aged between 18 and 35 years were divided into two homogeneous groups (1MHz and 3MHz). INTERVENTIONS: Continuous (CUT; 0...
December 5, 2017: Physiotherapy
https://www.readbyqxmd.com/read/29346155/diagnostic-and-therapeutic-ultrasound-on-venous-and-arterial-ulcers-a-focused-review
#5
(no author information available yet)
No abstract text is available yet for this article.
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29346145/diagnostic-and-therapeutic-ultrasound-on-venous-and-arterial-ulcers-a-focused-review
#6
Steven J Kavros, Robert Coronado
GENERAL PURPOSE: To provide information about the use of ultrasound for diagnostic and therapeutic treatment of venous and arterial ulcers. TARGET AUDIENCE: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care. LEARNING OBJECTIVES/OUTCOMES: After completing this continuing education activity, you should be able to: ABSTRACT: To review the diagnostic and therapeutic use of ultrasound on venous and arterial ulcers...
February 2018: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29318418/investigation-of-the-effectiveness-of-therapeutic-ultrasound-with-high-resolution-ultrasonographic-cross-sectional-area-measurement-of-cervical-nerve-roots-in-patients-with-chronic-cervical-radiculopathy-a-prospective-controlled-single-blind-study
#7
Burcu Metin Ökmen, Korgün Ökmen, Lale Altan
PURPOSE: The purpose of our study was to evaluate the effects of therapeutic ultrasound (US) on chronic cervical radiculopathy (CR) patients using both the clinical parameters and the cross-sectional area (CSA) values of the cervical nerve roots (NR) measured by high-resolution ultrasonography (HRUS). METHODS: Thirty-two patients with chronic CR were included in this prospective, controlled, and single-blind study. All of the patients received therapeutic US at continuous mode, 1-MHz frequency, and 1...
January 9, 2018: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/29278606/local-application-of-ultrasound-attenuates-neuropathic-allodynia-and-proinflammatory-cytokines-in-rats-after-thoracotomy
#8
Ching-Hsia Hung, Chong-Chi Chiu, Chen-Chih Liu, Yu-Wen Chen
BACKGROUND AND OBJECTIVES: We aimed to investigate the effect of therapeutic ultrasound (TU) on pain sensitivity and the concentration inflammatory cytokines in a thoracotomy rat model. METHODS: Rats were distributed randomly into 4 groups: (1) sham operated, (2) thoracotomy and rib retraction (TRR), (3) TRR rats that received TU (TRR + TU-1), and (4) TRR rats that received TU with the ultrasound turned off (TRR + TU-0). Ultrasound was set at 1-MHz frequency (1...
February 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29205374/ethyl-chloride-spray-for-musculoskeletal-ultrasound-guided-injections-an-alternative-to-subcutaneous-injection-of-local-anesthetic-solution
#9
Amit Shah, Alessandro Vidoni, Sharon McGarry, Mark Davies, Steven James, Rajesh Botchu
Ultrasound-guided injections such as steroid injections are common procedures involving the musculoskeletal system. They are usually performed after a subcutaneous injection of local anesthetic (LA), which can be painful. In 126 consecutive patients, local anesthesia was performed using ethyl chloride spray prior to a therapeutic ultrasound-guided injection in joints, tendons, or bursae. Ninety-nine (78.5%) patients found the use of ethyl chloride spray helpful. The use of ethyl chloride spray is an effective, patient-friendly alternative to the standard injection of local aesthetic for ultrasound-guided therapeutic musculoskeletal injections with the advantage of a lower cost of $0...
December 4, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29195473/clustering-dynamics-of-microbubbles-exposed-to-low-pressure-1-mhz-ultrasound
#10
Carole Lazarus, Antonios N Pouliopoulos, Marc Tinguely, Valeria Garbin, James J Choi
Ultrasound-driven microbubbles have been used in therapeutic applications to deliver drugs across capillaries and into cells or to dissolve blood clots. Yet the performance and safety of these applications have been difficult to control. Microbubbles exposed to ultrasound not only volumetrically oscillate, but also move due to acoustic radiation, or Bjerknes, forces. The purpose of this work was to understand the extent to which microbubbles moved and clustered due to secondary Bjerknes forces. A microbubble population was exposed to a 1-MHz ultrasound pulse with a peak-rarefactional pressure of 50-100 kPa and a pulse length of 20 ms...
November 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29132387/theoretically-proposed-optimal-frequency-for-ultrasound-induced-cartilage-restoration
#11
April D Miller, Anuradha Subramanian, Hendrik J Viljoen
BACKGROUND: Matching the frequency of the driving force to that of the system's natural frequency of vibration results in greater amplitude response. Thus we hypothesize that applying ultrasound at the chondrocyte's resonant frequency will result in greater deformation than applying similar ultrasound power at a frequency outside of the resonant bandwidth. Based on this resonant hypothesis, our group previously confirmed theoretically and experimentally that ultrasound stimulation of suspended chondrocytes at resonance (5 MHz) maximized gene expression of load inducible genes...
November 14, 2017: Theoretical Biology & Medical Modelling
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#12
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes A S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
November 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29122255/the-medium-term-effects-of-diadynamic-currents-in-chronic-low-back-pain-tens-versus-diadynamic-currents-a-randomised-follow-up-study
#13
Selcuk Sayilir, Mustafa Turgut Yildizgoren
OBJECTIVE: The aims of the study were to evaluate the medium-term effects of diadynamic (DD) currents on relieving symptoms/improving physical functionality in patients with chronic low back pain (LBP) and to compare the efficacy of DD versus TENS. METHODS: The patients were divided into two groups as the TENS group (n = 26) and the DD group (n = 29). Additional treatment of hot pack + therapeutic ultrasound was applied to all patients. The therapy programs were administered as a total of 10 sessions over a period of 2 weeks...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29118380/delivery-of-the-gene-encoding-the-tumor-suppressor-sef-into-prostate-tumors-by-therapeutic-ultrasound-inhibits-both-tumor-angiogenesis-and-growth
#14
Sabrin Mishel, Boris Shneyer, Lina Korsensky, Orit Goldshmidt-Tran, Tom Haber, Marcelle Machluf, Dina Ron
Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinomas, in a manner correlating with tumor aggressiveness. In vitro, hSef-b inhibited proliferation of TRAMP C2 cells and attenuated activation of ERK/MAPK and the master transcription factor NF-κB in response to FGF and IL-1/TNF, respectively...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096999/interstitial-matrix-prevents-therapeutic-ultrasound-from-causing-inertial-cavitation-in-tumescent-subcutaneous-tissue
#15
John P Koulakis, Joshua Rouch, Nhan Huynh, Genia Dubrovsky, James C Y Dunn, Seth Putterman
We search for cavitation in tumescent subcutaneous tissue of a live pig under application of pulsed, 1-MHz ultrasound at 8 W cm(-2) spatial peak and pulse-averaged intensity. We find no evidence of broadband acoustic emission indicative of inertial cavitation. These acoustic parameters are representative of those used in external-ultrasound-assisted lipoplasty and in physical therapy and our null result brings into question the role of cavitation in those applications. A comparison of broadband acoustic emission from a suspension of ultrasound contrast agent in bulk water with a suspension injected subcutaneously indicates that the interstitial matrix suppresses cavitation and provides an additional mechanism behind the apparent lack of in-vivo cavitation to supplement the absence of nuclei explanation offered in the literature...
October 31, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29066019/assessment-of-coded-excitation-implementation-for-estimating-heat-induced-speed-of-sound-changes
#16
Oren Gargir, Haim Azhari, Michael Zibulevsky
Speed of sound (SoS) is an acoustic property that is highly sensitive to changes in tissues. SoS can be mapped non-invasively using ultrasonic through transmission wave tomography. This however, practically limits its clinical use to the breast. A pulse-echo-based method that has broader clinical use and that can reliably measure treatment-induced changes in SoS even under poor signal-to-noise ratio (SNR) is highly desirable. The aim of this study was to evaluate the implementation of coded excitations (CoEs) to improve pulse-echo monitoring of heat-induced changes in the SoS...
October 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28979692/therapeutic-ultrasound-plus-pulsed-electromagnetic-field-improves-recovery-from-peripheral-arterial-disease-in-hypertension
#17
Zhao-Yang Lu, Hong-Sheng Zhou, Zhi-Xiao Su, Jia Qi, Jian Zhang, Guan-Hua Xue, Yue Li, Chang-Ning Hao, Yi-Qin Shi, Jun-Li Duan
The objective of this investigation was to evaluate the therapy effect of combined therapeutic ultrasound (TUS) treatment and pulsed electromagnetic field (PEMF) therapy on angiogenesis in hypertension-related hindlimb ischemia. After subjecting excision of the left femoral artery, spontaneously hypertensive rats (SHRs) were randomly distributed to one of four groups: SHR; TUS treated SHR (SHR-TUS); PEMF treated SHR (PEMF-TUS); and TUS plus PEMF treated SHR (SHR-TUS-PEMF). Wistar-Kyoto rats (WKYs) with femoral artery excision were regarded as a control group...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28968232/the-effect-of-kinesio%C3%A2-taping-on-pain-functionality-mobility-and-endurance-in-the-treatment-of-chronic-low-back-pain-a-randomized-controlled-study
#18
Fahri Köroğlu, Tuğba Kuru Çolak, M Gülden Polat
BACKGROUND: Low back pain is one of the most important causes of morbidity. OBJECTIVE: This study was designed to evaluate the effect of Kinesio® taping on pain, functionality, mobility and endurance in chronic low back pain treatment. METHODS: Patients with chronic low back pain were randomly divided into three groups. Therapeutic ultrasound, hot packs, and transcutaneous electrical nerve stimulation were applied to each group for ten sessions during two weeks, and therapeutic exercises were applied in the clinic under physiotherapist supervision starting from the sixth session...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28932004/effects-of-pulsed-therapeutic-ultrasound-on-the-treatment-of-people-with-knee-osteoarthritis
#19
Eliana-Isabel Rodríguez-Grande, Jose-Luis Osma-Rueda, Yannely Serrano-Villar, Carolina Ramírez
[Purpose] The aim was to evaluate the effect of therapeutic ultrasound on the pain, joint mobility, muscle strength, physical function, and quality of life of people with knee OA. [Subjects and Methods] One-site, one-arm, before-after study that included people with Grade II or III tibiofemoral osteoarthritis. Ten therapeutic ultrasound sessions (duty cycle=20%, ERA=10 cm(2), BNR=6:1, SATP=2.2 W/cm(2), SATA=0.44 W/cm(2), frequency=1 MHz, time=4 minutes) were applied. Assessments of primary outcome variables: pain intensity and function, and secondary variables: joint mobility, muscle strength and quality of life, were performed at onset and end of therapy; an additional intermediate evaluation was included for the primary variables...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929267/increasing-distribution-of-drugs-released-from-in-situ-forming-plga-implants-using-therapeutic-ultrasound
#20
Chawan Manaspon, Christopher Hernandez, Pinunta Nittayacharn, Selva Jeganathan, Norased Nasongkla, Agata A Exner
One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2...
December 2017: Annals of Biomedical Engineering
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