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'Therapeutic ultrasound'

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https://www.readbyqxmd.com/read/28776612/overcoming-t-gondii-infection-and-intracellular-protein-nanocapsules-as-biomaterials-for-ultrasonically-controlled-drug-release
#1
REVIEW
M S Aw, L Paniwnyk
One of the pivotal matters of concern in intracellular drug delivery is the preparation of biomaterials containing drugs that are compatible with the host target. Nanocapsules for oral delivery are found to be suitable candidates for targeting Toxoplasma gondii (T. gondii), a maneuvering and smart protozoic parasite found across Europe and America that causes a subtle but deadly infection. To overcome this disease, there is much potential of integrating protein-based cells into bioinspired nanocompartments such as via biodegradable cross-linked disulfide polyelectrolyte nanoparticles...
August 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28766896/novel-cranial-implants-of-yttria-stabilized-zirconia-as-acoustic-windows-for-ultrasonic-brain-therapy
#2
Mario I Gutierrez, Elias H Penilla, Lorenzo Leija, Arturo Vera, Javier E Garay, Guillermo Aguilar
Therapeutic ultrasound can induce changes in tissues by means of thermal and nonthermal effects. It is proposed for treatment of some brain pathologies such as Alzheimer's, Parkinson's, Huntington's diseases, and cancer. However, cranium highly absorbs ultrasound reducing transmission efficiency. There are clinical applications of transcranial focused ultrasound and implantable ultrasound transducers proposed to address this problem. In this paper, biocompatible materials are proposed for replacing part of the cranium (cranial implants) based on low porosity polycrystalline 8 mol% yttria-stabilized-zirconia (8YSZ) ceramics as acoustic windows for brain therapy...
August 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28753417/ex-vivo-determined-experimental-correction-factor-for-the-ultrasonic-source-term-in-the-bioheat-equation
#3
Guillermo A Cortela, Wagner C A Pereira, Carlos A Negreira
The objective of this work is to propose an effective absorption coefficient (αeffec) as an empirical correction factor in the source term of the bioheat equation. The temperature rise in biological tissue due to ultrasound insonification is produced by energy absorption. Usually, the ultrasonic absorption coefficient (αA) is used as a source term in the bioheat equation to quantify the temperature rise, and the effect of scattering is disregarded. The coefficient αeffec includes the scattering contribution as an additional absorption term and should allow us to make a better estimation of the thermal dose (TD), which is important for clinical applications...
July 19, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28739379/ultrasound-induced-bubble-clusters-in-tissue-mimicking-agar%C3%A2-phantoms
#4
Pooya Movahed, Wayne Kreider, Adam D Maxwell, Barbrina Dunmire, Jonathan B Freund
Therapeutic ultrasound can drive bubble activity that damages soft tissues. To study the potential mechanisms of such injury, transparent agar tissue-mimicking phantoms were subjected to multiple pressure wave bursts of the kind being considered specifically for burst wave lithotripsy. A high-speed camera recorded bubble activity during each pulse. Various agar concentrations were used to alter the phantom's mechanical properties, especially its stiffness, which was varied by a factor of 3.5. However, the maximum observed bubble radius was insensitive to stiffness...
October 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28738698/implementation-and-evaluation-of-a-rehabilitation-concept-in-a-patient-suffering-from-scleredema-adultorum-buschke-a-case-report
#5
Michael Mickel, Ahmad Jalili, Christina Gesslbauer, Richard Crevenna
PURPOSE: Scleredema Adultorum Buschke is a disorder manifesting indurations of the skin mostly followed by musculoskeletal impairment. Data regarding this fact are seldom found and documentation of functional outcome of physical therapies and modalities related to Scleredema Adultorum Buschke is fragmentary. The aim of this case report is to demonstrate and to document an effective concept of rehabilitation in a patient suffering from Scleredema Adultorum Buschke. METHODS: A treatment plan was developed containing therapeutic ultrasound, manual lymphatic drainage, and physiotherapy...
July 24, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28735734/variation-of-high-intensity-therapeutic-ultrasound-hitu-pressure-field-characterization-effects-of-hydrophone-choice-nonlinearity-spatial-averaging-and-complex-deconvolution
#6
Yunbo Liu, Keith A Wear, Gerald R Harris
Reliable acoustic characterization is fundamental for patient safety and clinical efficacy during high-intensity therapeutic ultrasound (HITU) treatment. Technical challenges, such as measurement variation and signal analysis, still exist for HITU exposimetry using ultrasound hydrophones. In this work, four hydrophones were compared for pressure measurement: a robust needle hydrophone, a small polyvinylidene fluoride capsule hydrophone and two fiberoptic hydrophones. The focal waveform and beam distribution of a single-element HITU transducer (1...
July 20, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28689485/therapeutic-ultrasound-after-sciatic-nerve-compression-of-wistar-rats
#7
Gladson Ricardo Flor Bertolini, Jhenifer Karvat, Camila Mayumi Martin Kakihata, Lucinéia de Fátima Chasko Ribeiro, Rose Meire Costa Brancalhão
OBJECTIVES: The present study analyzed the effect of therapy with therapeutic ultrasound on the sciatic nerve after compression injury, comparing two similar doses of SATA. METHODS: In total, 32 Wistar rats were used, divided into the following groups: CG - control; IG - compression injury of the sciatic nerve; IGCU - injury and continuous ultrasound; and IGPU - injury and 20% pulsed ultrasound. The treatment with ultrasound started on the 3rd postoperative day, with a frequency of 1 MHz, 0...
July 8, 2017: Neurological Research
https://www.readbyqxmd.com/read/28681404/integration-of-deployable-fluid-lenses-and-reflectors-with-endoluminal-therapeutic-ultrasound-applicators-preliminary-investigations-of-enhanced-penetration-depth-and-focal-gain
#8
Matthew S Adams, Vasant A Salgaonkar, Serena Scott, Graham Sommer, Chris J Diederich
PURPOSE: Catheter-based ultrasound applicators can generate thermal ablation of tissues adjacent to body lumens, but have limited focusing and penetration capabilities due to the small profile of integrated transducers required for the applicator to traverse anatomical passages. This study investigates a design for an endoluminal or laparoscopic ultrasound applicator with deployable acoustic reflector and fluid lens components, which can be expanded after device delivery to increase the effective acoustic aperture and allow for deeper and dynamically adjustable target depths...
July 6, 2017: Medical Physics
https://www.readbyqxmd.com/read/28633773/magnetic-resonance-imaging-and-clinical-outcomes-of-laser-therapy-ultrasound-therapy-and-extracorporeal-shock-wave-therapy-for-treatment-of-plantar-fasciitis-a-randomized-controlled-trial
#9
Aslihan Ulusoy, Lale Cerrahoglu, Sebnem Orguc
We determined and compared the effectiveness of low-level laser therapy (LLLT), therapeutic ultrasound (US) therapy, and extracorporeal shock wave therapy (ESWT) using magnetic resonance imaging (MRI). We performed a randomized, prospective, comparative clinical study. A total of 60 patients with a diagnosis of chronic plantar fasciitis were divided randomly into 3 treatment groups: group 1 underwent 15 sessions of LLLT (8 J/cm(2); 830 nm); group 2 underwent 15 sessions of continuous US (1 mHz; 2 W/cm(2)); and group 3 underwent 3 sessions of ESWT (2000 shocks)...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28588166/comparative-efficacy-of-local-steroid-and-therapeutic-ultrasound-for-quicker-functional-improvement-in-tennis-elbow
#10
M S Rahman, A K Salek, M A Ullah
Lateral epicondylitis or Tennis elbow is very common repetitive stress injury or cumulative trauma disorder among active professionals and tennis players. Local steroid injection can provide quick functional improvement as sought by most of the patients. Therapeutic ultrasound and eccentric exercises can also improve the function. This study was carried out to see the comparative efficacy of these two modalities of treatments in terms of quicker functional improvement and this randomized interventional clinical trial was carried out in a private rehabilitation hospital in Dhaka...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28579687/therapeutic-ultrasound-and-prostate-cancer
#11
REVIEW
Karthik M Sundaram, Sam S Chang, David F Penson, Sandeep Arora
Therapeutic ultrasound approaches including high-intensity focused ultrasound (HIFU) are emerging as popular minimally invasive alternative treatments for localized, low-to-intermediate risk prostate cancer. FDA approval was recently granted for two ultrasound-guided HIFU devices. Clinical trials for devices using MRI guidance are ongoing. The current level of evidence for whole-gland ultrasound ablation suggests that its clinical efficacy and adverse event rates including erectile dysfunction and urinary incontinence are similar to current definitive therapies such as radical prostatectomy and external-beam radiotherapy...
June 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/28541897/capacitive-micromachined-ultrasound-transducers-for-interstitial-high-intensity-ultrasound-therapies
#12
W Apoutou N'Djin, Bjoern Gerold, Jeremy Vion-Bailly, Michael S Canney, An Nguyen-Dinh, Alexandre Carpentier, Jean-Yves Chapelon
Capacitive micromachined ultrasound transducers (CMUTs) exhibit several potential advantages over conventional piezo technologies for use in therapeutic ultrasound (US) devices, including ease of miniaturization and integration with electronics, broad bandwidth (>several megahertz), and compatibility with magnetic resonance imaging (MRI). In this paper, the electroacoustic performance of CMUTs designed for interstitial high-intensity contact US (HICU) applications was evaluated and the feasibility of generating US-induced heating and thermal destruction of biological tissues was studied...
August 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28504325/therapeutic-ultrasound-for-venous-leg-ulcers
#13
REVIEW
Nicky Cullum, Zhenmi Liu
BACKGROUND: Venous leg ulcers are a type of chronic, recurring, complex wound that is more common in people aged over 65 years. Venous ulcers pose a significant burden to patients and healthcare systems. While compression therapy (such as bandages or stockings) is an effective first-line treatment, ultrasound may have a role to play in healing venous ulcers. OBJECTIVES: To determine whether venous leg ulcers treated with ultrasound heal more quickly than those not treated with ultrasound...
May 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28504278/high-frequency-linear-rheology-of-hydrogels-probed-by-ultrasound-driven-microbubble-dynamics
#14
Akaki Jamburidze, Marco De Corato, Axel Huerre, Angelo Pommella, Valeria Garbin
Ultrasound-driven microbubble dynamics are central to biomedical applications, from diagnostic imaging to drug delivery and therapy. In therapeutic applications, the bubbles are typically embedded in tissue, and their dynamics are strongly affected by the viscoelastic properties of the soft solid medium. While the behaviour of bubbles in Newtonian fluids is well characterised, a fundamental understanding of the effect on ultrasound-driven bubble dynamics of a soft viscoelastic medium is still being developed...
May 31, 2017: Soft Matter
https://www.readbyqxmd.com/read/28469805/therapeutic-ultrasound-protects-huvecs-from-ischemia-hypoxia-induced-apoptosis-via-the-pi3k-akt-pathway
#15
Jing-Juan Huang, Yi-Qin Shi, Rui-Lin Li, An Hu, Zhao-Yang Lu, Liang Weng, Yi-Peng Han, Shen-Qi Wang, Lan Zhang, Chang-Ning Hao, Jun-Li Duan
Background: Previous studies have demonstrated that therapeutic ultrasound (TUS) ameliorates angiogenesis on ischemic hind limb animals and also promotes human umbilical vein endothelial cells (HUVECs) tube formation. Apoptosis plays a key role in post-ischemic angiogenesis pathogenesis. However, the mechanisms underlying the anti-apoptotic effects of TUS are not clear. Therefore we put forward the hypothesis that TUS might promote angiogenesis during ischemia/hypoxia (I/H) by decreasing apoptosis. Methods: We investigated the cytoprotective role of TUS and the underlying mechanisms in I/H-induced HUVEC apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28464662/shock-formation-and-nonlinear-saturation-effects-in-the-ultrasound-field-of-a-diagnostic-curvilinear-probe
#16
Maria M Karzova, Petr V Yuldashev, Oleg A Sapozhnikov, Vera A Khokhlova, Bryan W Cunitz, Wayne Kreider, Michael R Bailey
Newer imaging and therapeutic ultrasound technologies may benefit from in situ pressure levels higher than conventional diagnostic ultrasound. One example is the recently developed use of ultrasonic radiation force to move kidney stones and residual fragments out of the urinary collecting system. A commercial diagnostic 2.3 MHz C5-2 array probe has been used to deliver the acoustic pushing pulses. The probe is a curvilinear array comprising 128 elements equally spaced along a convex cylindrical surface. The effectiveness of the treatment can be increased by using higher transducer output to provide a stronger pushing force; however nonlinear acoustic saturation can be a limiting factor...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28448428/therapeutic-ultrasound-in-navicular-stress-injuries-in-elite-track-and-field-athletes
#17
Nikolaos Malliaropoulos, Dimosthenis Alaseirlis, George Konstantinidis, Agapi Papalada, Ioannis Tsifountoudis, Kosmas Petras, Nicola Maffulli
OBJECTIVE: To ascertain whether therapeutic ultrasound (TUS) can be used to assess the progression of conservative management in navicular stress injuries. DESIGN: This is a prospective, clinical case series. Level of evidence IV. SETTING: All participants were examined and followed up in a private Sports Injury Clinic. PARTICIPANTS: Ten elite track and field athletes with severe dorsal midfoot pain over the navicular bone participated in this study...
May 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28433438/analgesic-effects-of-transcutaneous-ultrasound-nerve-stimulation-in-a-rat-model-of-oxaliplatin-induced-mechanical-hyperalgesia-and-cold-allodynia
#18
Yueh-Ling Hsieh, Han-Yu Chen, Ching-Hsiang Yang, Chen-Chia Yang
This study investigated the effects and underlying mechanisms of therapeutic ultrasound (TUS) in a rat model of oxaliplatin-induced peripheral neuropathy. Animals received a total of eight injections with oxaliplatin (4 mg/kg), administered at 3-d intervals. TUS intervention (1 MHz, 0.5 W/cm(2)) started on the fifth oxaliplatin administration and continued for 10 consecutive d. Sensory behavioral examinations, protein levels of transient receptor potential channels (TRPM8 and TRPV1) in dorsal root ganglia (DRG) and substance P (SP) in spinal dorsal horn were examined...
April 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28408818/anti-inflammatory-activity-of-niosomes-entrapped-with-plai-oil-zingiber-cassumunar-roxb-by-therapeutic-ultrasound-in-a-rat-model
#19
Jirakrit Leelarungrayub, Jiradej Manorsoi, Aranya Manorsoi
OBJECTIVE: The aim of this study was to evaluate the antioxidant and anti-inflammatory activities of Plai oil-encapsulated niosomes (Zingiber cassumunar Roxb.) on inflamed subcutaneous Wistar rat skin by therapeutic ultrasound. METHODS: Pure oil from Plai rhizomes was extracted by steam distillation, and antioxidant activities were determined by 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay. Bioactive compounds were analyzed by gas chromatography-mass spectrometry...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28408061/predicting-tissue-susceptibility-to-mechanical-cavitation-damage-in-therapeutic-ultrasound
#20
Lauren Mancia, Eli Vlaisavljevich, Zhen Xu, Eric Johnsen
Histotripsy is a developing focused ultrasound procedure that uses cavitation bubbles to mechanically homogenize soft tissue. To better understand the mechanics of tissue damage, a numerical model of single-bubble dynamics was used to calculate stress, strain and strain rate fields produced by a cavitation bubble exposed to a tensile histotripsy pulse. The explosive bubble growth and its subsequent collapse were found to depend on the properties of the surrounding material and on the histotripsy pulse. Stresses far greater than gigapascals were observed close to the bubble wall, but attenuated by four to six orders of magnitude within 50 μm from the bubble wall, with at least two orders of magnitude attenuation occurring within the first 10 μm from the bubble...
July 2017: Ultrasound in Medicine & Biology
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