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'Therapeutic ultrasound'

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https://www.readbyqxmd.com/read/28322306/ultrasound-mediated-delivery-of-oxygen-and-lll12-loaded-stimuli-responsive-microdroplets-for-the-treatment-of-hypoxic-cancer-cells
#1
Jinshun Xu, Shuai Yuan, Jilai Tian, Kyle A Martin, Jinhua Song, Chenglong Li, Zhigang Wang, Jiayuh Lin, Ting Si, Ronald X Xu
LLL12 exhibits high specificity for inhibiting STAT3 phosphorylation and dimerization, and inducing apoptosis to constitutively activated STAT3 cancer cells without cytotoxicity to normal cells with dormant STAT3. However, clinical deployment of LLL12 in cancer treatment is hindered by its low bioavailability and hypoxia-induced resistance. To overcome these limitations, we encapsulate both oxygen and LLL12 in stimuli responsive microdroplets (SRMs) by a gas-driven coaxial flow focusing (CFF) process for ultrasound mediated treatment of hypoxic cancer cells...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28319508/exercise-combined-with-ultrasound-attenuates-neuropathic-pain-in-rats-associated-with-downregulation-of-il-6-and-tnf-%C3%AE-but-with-upregulation-of-il-10
#2
Po-Ching Huang, Kun-Ling Tsai, Yu-Wen Chen, Heng-Teng Lin, Ching-Hsia Hung
BACKGROUND: Although there are several evidences that suggest efficacies of therapeutic ultrasound (TU) or treadmill exercise (TE) to alleviate nerve injury-associated pain, molecular mechanisms are less clear. We aimed to investigate the impact of TU and/or TE on neuropathic pain induced by chronic constriction injury (CCI) of the sciatic nerve and their roles of proinflammatory and anti-inflammatory cytokines. METHODS: Rats were randomly divided into (n = 10 per group) sham operation (sham), CCI procedure followed by false application of TU (CCI + TU0), CCI procedure followed by false application of TU and TE (CCI + TU0 + TE), CCI, and CCI procedure followed by TU alone (CCI + TU), TE alone (CCI + TE), or both TU and TE (CCI + TU + TE) groups...
March 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28265413/microvessel-rupture-induced-by-high-intensity-therapeutic-ultrasound-a-study-of-parameter-sensitivity-in-a-simple-in-vivo-model
#3
Yeonho Kim, Marjan Nabili, Priyanka Acharya, Asis Lopez, Matthew R Myers
BACKGROUND: Safety analyses of transcranial therapeutic ultrasound procedures require knowledge of the dependence of the rupture probability and rupture time upon sonication parameters. As previous vessel-rupture studies have concentrated on a specific set of exposure conditions, there is a need for more comprehensive parametric studies. METHODS: Probability of rupture and rupture times were measured by exposing the large blood vessel of a live earthworm to high-intensity focused ultrasound pulse trains of various characteristics...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28263564/theranostic-multilayer-capsules-for-ultrasound-imaging-and-guided-drug-delivery
#4
Jun Chen, Sithira Ratnayaka, Aaron Alford, Veronika Kozlovskaya, Fei Liu, Bing Xue, Kenneth Hoyt, Eugenia Kharlampieva
Despite the accessibility of ultrasound, the clinical potential of ultrasound-active theranostic agents has not been fully realized because it requires combining sufficient imaging contrast, high encapsulation efficiency and ultrasound-triggered release in one entity. We report on theranostic polymer microcapsules composed of hydrogen-bonded multilayers of tannic acid and poly(N-vinylpyrrolidone) that produce high imaging contrast and deliver the anticancer drug doxorubicin upon low-power diagnostic or high-power therapeutic ultrasound irradiation...
March 6, 2017: ACS Nano
https://www.readbyqxmd.com/read/28253700/the-effects-of-heat-and-mass-diffusion-on-freely-oscillating-bubbles-in-a-viscoelastic-tissue-like-medium
#5
Carlos Barajas, Eric Johnsen
In certain cavitation-based ultrasound techniques, the relative importance of thermally vs mechanically induced damage is unclear. As a first step to investigate this matter, a numerical model for bubble dynamics in tissue-like, viscoelastic media is presented in which full thermal effects are included inside and outside the bubble, as well as interdiffusion of vapor and non-condensible gas inside the bubble. Soft tissue is assumed to behave according to a Kelvin-Voigt model in which viscous and elastic contributions are additive...
February 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28244011/focused-ultrasound-an-emerging-therapeutic-modality-for-neurologic-disease
#6
Paul S Fishman, Victor Frenkel
Therapeutic ultrasound is only beginning to be applied to neurologic conditions, but the potential of this modality for a wide spectrum of brain applications is high. Engineering advances now allow sound waves to be targeted through the skull to a brain region selected with real time magnetic resonance imaging and thermography, using a commercial array of focused emitters. High intensities of sonic energy can create a coagulation lesion similar to that of older radiofrequency stereotactic methods, but without opening the skull...
February 27, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28211702/antimicrobial-effect-of-biocompatible-silicon-nanoparticles-activated-using-therapeutic-ultrasound
#7
Svetlana N Shevchenko, Markus Burkhardt, Eugene V Sheval, Ulyana A Natashina, Christina Grosse, Alexander L Nikolaev, Alexander V Gopin, Ute Neugebauer, Andrew A Kudryavtsev, Vladimir Sivakov, Liubov A Osminkina
In this study, we report a method for the suppression of Escherichia coli (E. coli) vitality by means of therapeutic ultrasound irradiation (USI) using biocompatible silicon nanoparticles as cavitation sensitizers. Silicon nanoparticles without (SiNPs) and with polysaccharide (dextran) coating (DSiNPs) were used. Both types of nanoparticles were nontoxic to Hep 2 cells up to a concentration of 2 mg/mL. The treatment of bacteria with nanoparticles and application of 1 W/cm(2) USI resulted in the reduction of their viabilities up to 35 and 72% for SiNPs and DSiNPs, respectively...
March 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28211622/mri-guided-focused-ultrasound-robotic-system-for-animal-experiments
#8
Marinos Yiannakou, Georgios Menikou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
BACKGROUND: In this paper an MRI-guided focused ultrasound (MRgFUS) robotic system was developed that can be used for conducting experiments in small animals.The target for this robotic system regarding motion was to move a therapeutic ultrasound transducer in two Cartesian axes. METHODS: A single element spherically focused transducer of 3 cm diameter, focusing at 7 cm and operating at 0.4 MHz was used. The positioning device incorporates only MRI compatible materials...
February 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28194375/rehabilitation-of-hamstring-muscle-injuries-a-literature-review
#9
REVIEW
Gabriel Amorim Ramos, Gustavo Gonçalves Arliani, Diego Costa Astur, Alberto de Castro Pochini, Benno Ejnisman, Moisés Cohen
Hamstring injuries are among the most frequent in sports. The high relapse rate is a challenge for sports medicine and has a great impact on athletes and sport teams. The treatment goal is to provide the athlete the same functional level as before the injury. Thus, functional rehabilitation is very important to the success of the treatment. Currently, several physical therapy modalities are used, according to the stage of the lesion, such as cryotherapy, laser therapy, therapeutic ultrasound, therapeutic exercise, and manual therapy...
January 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28182513/effects-of-long-duration-low-intensity-ultrasound-for-active-trapezius-trigger-points-a-randomized-clinical-trial
#10
Justin H Rigby, David O Draper
CONTEXT: Upper trapezius trigger points can be debilitating and often lead to chronic pain. OBJECTIVE: To determine if long duration low intensity therapeutic ultrasound is effective at treating upper trapezius trigger point pain compared to an inactive placebo treatment. DESIGN: Randomized control trial. SETTING: Research laboratory. PATIENTS OR OTHER PARTICIPANTS: Fifty-one participants (19 males, 32 females, age = 31...
February 9, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28177935/cytotoxicity-control-of-silicon-nanoparticles-by-biopolymer-coating-and-ultrasound-irradiation-for-cancer-theranostic-applications
#11
A P Sviridov, L A Osminkina, A Yu Kharin, M B Gongansky, J V Kargina, A A Kudryavtsev, Yu I Bezsudnova, T S Perova, A Geloen, V Lysenko, V Yu Timoshenko
Silicon nanoparticles (SiNPs) prepared by mechanical grinding of luminescent porous silicon were coated with a biopolymer (dextran) and investigated as a potential theranostic agent for bioimaging and sonodynamic therapy. Transmission electron microscopy, photoluminescence and Raman scattering measurements of dextran-coated SiNPs gave evidence of their enhanced stability in water. In vitro experiments confirmed the lower cytotoxicity of the dextran-coated NPs in comparison with uncoated ones, especially for high concentrations of about 2 mg ml(-1)...
March 10, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28174191/augmentation-of-muscle-blood-flow-by-ultrasound-cavitation-is-mediated-by-atp-and-purinergic-signaling
#12
J Todd Belcik, Brian P Davidson, Aris Xie, Melinda D Wu, Mrinal Yadava, Yue Qi, Sherry Liang, Chae Ryung Chon, Azzdine Y Ammi, Joshua Field, Leanne Harmann, William M Chilian, Joel Linden, Jonathan R Lindner
BACKGROUND: - Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that purinergic signalling is responsible for shear-dependent increases in muscle perfusion during therapeutic cavitation. METHODS: -Unilateral exposure of the proximal hindlimb of mice (with or without ischemia produced by iliac ligation) to therapeutic ultrasound (1...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28169315/ultrasound-mediated-mesenchymal-stem-cells-transfection-as-a-targeted-cancer-therapy-platform
#13
Tom Haber, Limor Baruch, Marcelle Machluf
Mesenchymal stem cells (MSCs) hold tremendous potential as a targeted cell-based delivery platform for inflammatory and cancer therapy. Genetic manipulation of MSCs, however, is challenging, and therefore, most studies using MSCs as therapeutic cell carriers have utilized viral vectors to transduce the cells. Here, we demonstrate, for the first time, an alternative approach for the efficient transfection of MSCs; therapeutic ultrasound (TUS). Using TUS with low intensities and moderate frequencies, MSCs were transfected with a pDNA encoding for PEX, a protein that inhibits tumor angiogenesis, and studied as a cell vehicle for in vivo tumor therapy...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149518/why-we-should-care-about-soft-tissue-interfaces-when-applying-ultrasonic-diathermy-an-experimental-and-computer-simulation-study
#14
Thaís Pionório Omena, Aldo José Fontes-Pereira, Rejane Medeiros Costa, Ricardo Jorge Simões, Marco Antônio von Krüger, Wagner Coelho de Albuquerque Pereira
BACKGROUND: One goal of therapeutic ultrasound is enabling heat generation in tissue. Ultrasound application protocols typically neglect these processes of absorption and backscatter/reflection at the skin/fat, fat/muscle, and muscle/bone interfaces. The aim of this study was to investigate the heating process at interfaces close to the transducer and the bone with the aid of computer simulation and tissue-mimicking materials (phantoms). METHODS: The experimental setup consists of physiotherapeutic ultrasound equipment for irradiation, two layers of soft tissue-mimicking material, and one with and one without an additional layer of bone-mimicking material...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28144159/anterior-cutaneous-nerve-entrapment-syndrome-management-challenges
#15
REVIEW
Eleni Chrona, Georgia Kostopanagiotou, Dimitrios Damigos, Chrysanthi Batistaki
Anterior cutaneous nerve entrapment syndrome (ACNES) is a commonly underdiagnosed and undertreated chronic state of pain. This syndrome is characterized by the entrapment of the cutaneous branches of the lower thoracoabdominal intercostal nerves at the lateral border of the rectus abdominis muscle, which causes severe, often refractory, chronic pain. This narrative review aims to identify the possible therapeutic strategies for the management of the syndrome. Seventeen studies about ACNES therapy were reviewed; of them, 15 were case-control studies, case series, or case reports, and two were randomized controlled trials...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28113915/therapeutic-modulation-of-calcium-dynamics-using-ultrasound-and-other-energy-based-techniques
#16
Ivan Castellanos, Bogdan Balteanu, Tania Singh, Vesna Zderic
Ultrasound, along with other types of energy-based methods, has been widely investigated for use in various therapeutic applications because of its ability to stimulate specific biological processes. Many of these processes are mediated by calcium (Ca2+) signaling, thus making modulation of Ca2+ dynamics an evident therapeutic target for energy-based techniques. Various diseases have been associated with abnormal Ca2+ signaling and could therefore benefit from therapeutic approaches trying to regulate the transport of Ca2+ across cell membranes...
April 21, 2016: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28113891/design-of-a-collapse-mode-cmut-with-an-embossed-membrane-for-improving-output-pressure
#17
Yuanyu Yu, Sio Pun, Peng Un Mak, Ching-Hsiang Cheng, Jiujiang Wang, Pui In Mak, Mang I Vai
Capacitive micromachined ultrasonic transducers (CMUTs) have emerged as a competitive alternative to piezoelectric ultrasonic transducers, especially in medical ultrasound imaging and therapeutic ultrasound applications which require high output pressure. However, as compared with piezoelectric ultrasonic transducers, the output pressure capability of CMUTs remains to be improved. In this paper, a novel structure is proposed by forming an embossed vibrating membrane on a CMUT cell operating in the collapse-mode to increase the maximum output pressure...
April 15, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28075090/carpal-tunnel-syndrome-diagnosis-and-management
#18
Jennifer Wipperman, Kyle Goerl
Carpal tunnel syndrome, the most common entrapment neuropathy of the upper extremity, is caused by compression of the median nerve as it travels through the carpal tunnel. Classically, patients with the condition experience pain and paresthesias in the distribution of the median nerve, which includes the palmar aspect of the thumb, index and middle fingers, and radial half of the ring finger. Additional clues include positive physical examination findings, such as the flick sign, Phalen maneuver, and median nerve compression test...
December 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/28035912/effectiveness-of-therapeutic-ultrasound-with-or-without-thumb-spica-splint-in-the-management-of-de-quervain-s-disease
#19
Waqar Ahmed Awan, Muhammad Naveed Babur, Tahir Masood
BACKGROUND: The management of De Quervain's disease is determined more by Intuition than scientific data. The choice of first line conservative option for the management of De Quervain's disease is still a topic of debate. AIM: To evaluate the effectiveness of therapeutic ultrasound with or without spica splint in the management of De Quervain's disease (DQD). DESIGN: Randomized controlled trial (RCT). SETTING: Outpatient department of Al-Nafees Medical College Hospital, Islamabad, Pakistan...
December 23, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28026755/passive-acoustic-mapping-with-the-angular-spectrum-method
#20
Costas Arvanitis, Calum Crake, Nathan McDannold, Gregory Clement
In the present proof of principle study, we evaluated the homogenous angular spectrum method for passive acoustic mapping (AS-PAM) of microbubble oscillations using simulated and experimental data. In the simulated data we assessed the ability of AS-PAM to form 3D maps of a single and multiple point sources. Then, in the two dimensional limit, we compared the 2D maps from AS-PAM with alternative frequency and time domain passive acoustic mapping (FD- and TD-PAM) approaches. Finally, we assessed the ability of AS-PAM to visualize microbubble activity in vivo with data obtained during 8 different experiments of FUS-induced blood-brain barrier disruption in 3 nonhuman primates, using a clinical MR-guided FUS system...
December 21, 2016: IEEE Transactions on Medical Imaging
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