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https://www.readbyqxmd.com/read/28099199/chronic-lateral-epiphyseal-separation-of-the-proximal-tibia-causes-late-onset-tibia-vara
#1
Sachi Hasegawa, Hiroshi Kitoh, Masaki Matsushita, Kenichi Mishima, Izumi Kadono, Hiroshi Sugiura, Akiko Kitamura, Naoki Ishiguro
An adolescent obese boy showed late-onset unilateral tibia vara associated with physeal separation (slipped epiphysis) of the lateral proximal tibia and physeal widening of the lateral distal femur. These affected physes showed normal signal intensities by MRI. He was treated with lateral hemiepiphysiodesis of the left proximal tibia and the distal femur using two parallel eight-Plates, and varus deformity rapidly improved postoperatively without recurrence. This is the first case of late-onset tibia vara caused by lateral physeal separation of the proximal tibia...
January 17, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28095169/examination-of-knee-morphology-after-secondary-ipsilateral-acl-injury-compared-to-those-that-have-not-reinjured-a-preliminary-study
#2
Jessica E Digiacomo, Riann M Palmieri-Smith, John A Redmann, Lindsey K Lepley
CONTEXT: Modifiable and non-modifiable risk factors have been identified for sustaining a primary ACL injury, however less research is available examining risk factors for a second injury. Identifying whether bony morphological factors are different (or more exaggerated) among those that experience a secondary ACL injury is critical to understanding if non-modifiable risk factors are associated with a second injury. OBJECTIVE: To identify if bony morphology is different among those that experience a secondary ACL re-injury as compared to ACL individuals that do not...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28092725/strontium-ranelate-a-promising-disease-modifying-osteoarthritis-drug
#3
Weiyu Han, Shicai Fan, Xiaochun Bai, Changhai Ding
The articular cartilage and subchondral bone may have potential crosstalk in the development and progression of osteoarthritis (OA). Strontium ranelate (SrR) has the ability to dissociate the bone remodeling process and to change the balance between bone resorption and bone formation. Its effect on subchondral bone makes it a potential disease- modifying osteoarthritis drug (DMOAD) in the treatment of OA. The aim of the current review is to summarize up-to-date pharmacological and clinical data of SrR for OA treatment...
January 16, 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28090448/quantitative-techniques-for-musculoskeletal-mri-at-7-tesla
#4
REVIEW
Neal K Bangerter, Meredith D Taylor, Grayson J Tarbox, Antony J Palmer, Daniel J Park
Whole-body 7 Tesla MRI scanners have been approved solely for research since they appeared on the market over 10 years ago, but may soon be approved for selected clinical neurological and musculoskeletal applications in both the EU and the United States. There has been considerable research work on musculoskeletal applications at 7 Tesla over the past decade, including techniques for ultra-high resolution morphological imaging, 3D T2 and T2* mapping, ultra-short TE applications, diffusion tensor imaging of cartilage, and several techniques for assessing proteoglycan content in cartilage...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090444/bone-marrow-edema-like-lesions-bmels-are-associated-with-higher-t1%C3%AF-and-t2-values-of-cartilage-in-anterior-cruciate-ligament-acl-reconstructed-knees-a-longitudinal-study
#5
Jingshan Gong, Valentina Pedoia, Luca Facchetti, Thomas M Link, C Benjamin Ma, Xiaojuan Li
BACKGROUND: To evaluate the longitudinal changes of bone marrow edema-like lesions (BMELs) in patients after anterior cruciate ligament (ACL) reconstruction and to investigate the effect of BMELs on cartilage matrix composition changes measured using MR T1ρ and T2 mapping. METHODS: Patients with acute ACL tear were enrolled in a prospective study. MR imaging was performed at baseline (before surgeries) and at 6-month, 1-year and 2-year after ACL reconstruction...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090443/topographical-and-depth-dependent-glycosaminoglycan-concentration-in-canine-medial-tibial-cartilage-3-weeks-after-anterior-cruciate-ligament-transection-surgery-a-microscopic-imaging-study
#6
Daniel Mittelstaedt, David Kahn, Yang Xia
BACKGROUND: Medical imaging has become an invaluable tool to diagnose damage to cartilage. Depletion of glycosaminoglycans (GAG) has been shown to be one of the early signs of cartilage degradation. In order to investigate the topographical changes in GAG concentration caused by the anterior cruciate ligament transection (ACLT) surgery in a canine model, microscopic magnetic resonance imaging (µMRI) and microscopic computed tomography (µCT) were used to measure the GAG concentration with correlation from a biochemical assay, inductively coupled plasma optical emission spectroscopy (ICP-OES), to understand where the topographical and depth-dependent changes in the GAG concentration occur...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28090441/principal-component-analysis-t1%C3%AF-voxel-based-relaxometry-of-the-articular-cartilage-a-comparison-of-biochemical-patterns-in-osteoarthritis-and-anterior-cruciate-ligament-subjects
#7
Valentina Pedoia, Colin Russell, Allison Randolph, Xiaojuan Li, Sharmila Majumdar
BACKGROUND: Quantitative MR, including T1ρ mapping, has been extensively used to probe early biochemical changes in knee articular cartilage of subjects with osteoarthritis (OA) and others at risk for cartilage degeneration, such as those with anterior cruciate ligament (ACL) injury and reconstruction. However, limited studies have been performed aimed to assess the spatial location and patterns of T1ρ. In this study we used a novel voxel-based relaxometry (VBR) technique coupled with principal component analysis (PCA) to extract relevant features so as to describe regional patterns and to investigate their similarities and differences in T1ρ maps in subjects with OA and subjects six months after ACL reconstruction (ACLR)...
December 2016: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28089940/assessing-the-effect-of-football-play-on-knee-articular-cartilage-using-delayed-gadolinium-enhanced-mri-of-cartilage-dgemric
#8
Wenbo Wei, Becky Lambach, Guang Jia, David Flanigan, Ajit M W Chaudhari, Lai Wei, Alan Rogers, Jason Payne, Robert A Siston, Michael V Knopp
The prevalence of cartilage lesions is much higher in football athletes than in the general population. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been shown to quantify regional variations of glycosaminoglycan (GAG) concentrations which is an indicator of early cartilage degeneration. The goal of this study is to determine whether dGEMRIC can be used to assess the influence in cartilage GAG concentration due to college level football play. Thirteen collegiate football players with one to four years of collegiate football play experience were recruited and both knee joints were scanned using a dedicated 8-channel phased array knee coil on a 3T MRI system...
January 12, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28076431/knee-cartilage-thickness-t1%C3%AF-and-t2-relaxation-time-are-related-to-articular-cartilage-loading-in-healthy-adults
#9
Sam Van Rossom, Colin Robert Smith, Lianne Zevenbergen, Darryl Gerard Thelen, Benedicte Vanwanseele, Dieter Van Assche, Ilse Jonkers
Cartilage is responsive to the loading imposed during cyclic routine activities. However, the local relation between cartilage in terms of thickness distribution and biochemical composition and the local contact pressure during walking has not been established. The objective of this study was to evaluate the relation between cartilage thickness, proteoglycan and collagen concentration in the knee joint and knee loading in terms of contact forces and pressure during walking. 3D gait analysis and MRI (3D-FSE, T1ρ relaxation time and T2 relaxation time sequence) of fifteen healthy subjects were acquired...
2017: PloS One
https://www.readbyqxmd.com/read/28075623/identifying-hidden-zones-of-the-far-posterior-cartilage-of-the-femoral-condyles-not-visible-during-knee-arthroscopy
#10
Mark J Sando, Sean S Rajaee, Joseph P Liu, Michael Banffy, Orr Limpisvasti, John V Crues
OBJECTIVE: The purpose of this study was to compare standard knee arthroscopic and MRI findings and measurements for visualization of the femoral condyle articular cartilage. The hypothesis was that certain posterior cartilage defects identified with MRI may not be accessible with routine arthroscopy. MATERIALS AND METHODS: Six cadaveric knees were examined by routine arthroscopy through standard inferomedial and inferolateral portals. Suture anchors were inserted into the femoral condyles at 30°, 60°, 90°, and 120° of flexion as markers of the cartilage surface at the most posterior aspect of the condyle that could be accessed at each degree of flexion...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28075154/survivorship-after-meniscal-allograft-transplantation-according-to-articular-cartilage-status
#11
Bum-Sik Lee, Seong-Il Bin, Jong-Min Kim, Won-Kyeong Kim, Jun Weon Choi
BACKGROUND: Clinical outcomes after meniscal allograft transplantation (MAT) in arthritic knees are unclear, and objective estimates of graft survival according to the articular cartilage status have not been performed. HYPOTHESIS: MAT should provide clinical benefits in knees with high-grade cartilage damage, but their graft survivorship should be inferior to that in knees with low-grade chondral degeneration after MAT. STUDY DESIGN: Cohort study; Level of evidence, 3...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28068480/magnetic-resonance-imaging-characterization-and-clinical-outcomes-after-neocart-surgical-therapy-as-a-primary-reparative-treatment-for-knee-cartilage-injuries
#12
Devon E Anderson, Riley J Williams, Thomas M DeBerardino, Dean C Taylor, C Benjamin Ma, Marie S Kane, Dennis C Crawford
BACKGROUND: Autologous cartilage tissue implants, including the NeoCart implant, are intended to repair focal articular cartilage lesions. Short-term results from United States Food and Drug Administration (FDA) phase I and phase II clinical trials indicated that the NeoCart implant was safe when surgically applied as a cell-based therapy and efficacious compared with microfracture. HYPOTHESIS: Quantitative magnetic resonance imaging (MRI) analysis would reveal NeoCart tissue maturation through to 60-month follow-up...
January 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28065381/the-contribution-of-3d-quantitative-meniscal-and-cartilage-measures-to-variation-in-normal-radiographic-joint-space-width-data-from-the-osteoarthritis-initiative-healthy-reference-cohort
#13
Melanie Roth, Wolfgang Wirth, Katja Emmanuel, Adam G Culvenor, Felix Eckstein
OBJECTIVE: To explore to what extent three-dimensional measures of the meniscus and femorotibial cartilage explain the variation in medial and lateral femorotibial radiographic joint space width (JSW), in healthy men and women. METHODS: The right knees of 87 Osteoarthritis Initiative healthy reference participants (no symptoms, radiographic signs or risk factors of osteoarthritis; 37 men, 50 women; age 55.0±7.6; BMI 24.4±3.1) were assessed. Quantitative measures of subregional femorotibial cartilage thickness and meniscal position and morphology were computed from segmented magnetic resonance images...
February 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28064033/altered-gait-mechanics-and-elevated-serum-pro-inflammatory-cytokines-in-asymptomatic-patients-with-mri-evidence-of-knee-cartilage-loss
#14
Shannon N Edd, Julien Favre, Katerina Blazek, Patrick Omoumi, Jessica L Asay, Thomas P Andriacchi
OBJECTIVE: To test if sagittal plane gait mechanics parameters and serum inflammation levels differ between healthy asymptomatic subjects and asymptomatic subjects with magnetic resonance imaging (MRI) evidence of cartilage loss. DESIGN: Gait mechanics and resting serum tumor necrosis factor-α (TNFα) concentrations were measured for two groups of asymptomatic subjects recruited for a previous study: Pre-Osteoarthritis (OA) subjects had MRI evidence of partial- or full-thickness knee cartilage loss in at least one compartment (n=52 (30 female), 1...
January 4, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28060534/is-it-necessary-to-repair-stable-ramp-lesions-of-the-medial-meniscus-during-anterior-cruciate-ligament-reconstruction
#15
Xin Liu, Hui Zhang, Hua Feng, Lei Hong, Xue-Song Wang, Guan-Yang Song
BACKGROUND: A special type of meniscal lesion involving the peripheral attachment of the posterior horn of the medial meniscus (PHMM), termed a "ramp lesion," is commonly associated with an anterior cruciate ligament (ACL) injury. However, its treatment is still controversial. Recently, stable ramp lesions treated with abrasion and trephination alone have been shown to have good clinical outcomes after ACL reconstruction. HYPOTHESIS: Stable ramp lesions treated with abrasion and trephination alone during ACL reconstruction will result in similar clinical outcomes compared with those treated with surgical repair...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28057477/localized-and-diffuse-forms-of-tenosynovial-giant-cell-tumor-formerly-giant-cell-tumor-of-the-tendon-sheath-and-pigmented-villonodular-synovitis
#16
REVIEW
F Gouin, T Noailles
Tenosynovial giant cell tumor (TSGCT) is a rare benign tumor arising from joint synovia, bursae and tendon sheaths. Their variable clinical presentation is related to variations in site and progression. Localized forms are most frequent in the hands, and diffuse forms in the knee. MRI is necessary and sometimes sufficient for diagnosis. Treatment strategy is guided by progression, symptomatology, location and diathesis. Optimally complete resection is the principle of first-line treatment. Radiation therapy is effective and targeted therapies are promising; both should especially be considered in case of relapse...
January 2, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28057326/meniscus-morphology-does-tear-type-matter-a-narrative-review-with-focus-on-relevance-for-osteoarthritis-research
#17
REVIEW
Mohamed Jarraya, Frank W Roemer, Martin Englund, Michel D Crema, Heather I Gale, Daichi Hayashi, Jeffrey N Katz, Ali Guermazi
OBJECTIVE: To give a narrative overview of meniscal tears with a radiologic emphasis on the morphologic type, technical considerations, and on the relevance of the type of meniscal tear in the context of osteoarthritis (OA) research. DESIGN: Total 20 years of the PubMed database were searched for epidemiological, radiological, arthroscopic and biomechanical reports, and review articles focusing on meniscal tears in middle-aged and older individuals, in the setting of OA...
November 24, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28056523/the-tibial-tubercle-trochlear-groove-distance-is-greater-in-patients-with-patellofemoral-pain
#18
Victor R Carlson, Barry P Boden, Aricia Shen, Jennifer N Jackson, Lawrence Yao, Frances T Sheehan
BACKGROUND: The distance between the tibial tubercle (TT) and trochlear groove (TT-TG distance) is known to be greater in patients with patellar instability. However, the potential role and prevalence of pathological TT-TG distances in a large cohort of skeletally mature patients with isolated patellofemoral pain (PFP) are not clear. PURPOSE: To determine if the mean TT-TG distance is greater in patients with PFP, who lack a history of patellar dislocations, knee trauma, or osteoarthritis, relative to healthy controls...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28056183/cell-seeded-autologous-chondrocyte-implantation
#19
Andreas H Gomoll, Amy Phan, Marissa Mastrocola, Luiz Felipe Ambra, Nehal Shah
BACKGROUND: The use of autologous chondrocyte implantation (ACI) remains limited, even though multiple studies have demonstrated success rates exceeding 75%. The procedure is perceived as invasive and technically challenging, presenting barriers to more widespread adoption. Purpose/Hypothesis: The objective of this study was to investigate whether outcomes and the failure rate of a simplified ACI technique (cs-ACI) were comparable with those of the more complicated traditional technique of a chondrocyte suspension injected under a collagen membrane (cACI)...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28053391/a-prospective-study-to-evaluate-the-clinico-radiological-outcomes-of-arthroscopic-single-bundle-versus-double-bundle-anterior-cruciate-ligament-reconstruction
#20
Ashish Devgan, Rajesh Rohilla, Amanpreet Singh, Milind Tanwar, Radhika Devgan, Karan Siwach
INTRODUCTION: The aim of the study was to compare clinical and radiological outcomes of arthroscopic single-bundle versus double-bundle anterior cruciate ligament (ACL) reconstruction. PATIENT AND METHODS: 60 patients with isolated ACL injury were divided into single bundle (SB) (n = 30) and double bundle (DB) reconstruction groups (n = 30) and operated between July 2009 and July 2012. Outcome evaluation was performed using GNRB arthrometer, International Knee Documentation Committee & Lysholm scale...
October 2016: Journal of Clinical Orthopaedics and Trauma
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