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https://read.qxmd.com/read/38468583/-not-available
#21
JOURNAL ARTICLE
Ines Naceur, Sahar Skhiri, Tayssir Ben Achour, Fatma Said, Monia Smiti, Imed Ben Ghorbel, Mohamed Habib Houman
AIM: To describe characteristics of systemic lupus erythematosus (SLE) patients with infectious complications and to determine frequency, clinical and microbiological features and outcomes of reported infections. METHODS: This is a descriptive, retrospective study conducted over an 11-year period at the Internal Medicine Department La Rabta Hospital Tunis, collecting medical records of SLE patients who had experienced infectious complications. RESULTS: Fifty-six patients were included, consisting of 52 females and 4 males (gender ratio M/F= 0...
November 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38467144/direct-oral-anticoagulants-for-pulmonary-embolism
#22
JOURNAL ARTICLE
Roberto Pizzi, Ludovica Anna Cimini, Walter Ageno, Cecilia Becattini
Venous thromboembolism (VTE) is the third most common cardiovascular disease. For most patients, the standard of treatment has long consisted on low-molecular-weight heparin followed by vitamin K antagonists, but a number of clinical trials and, subsequently, post-marketing studies have shown that direct oral anticoagulants (DOACs) with or without lead-in heparin therapy are effective alternatives with fewer adverse effects. This evidence has led to important changes in the guidelines on the treatment of VTE, including pulmonary embolism (PE), with the DOACs being now recommended as the first therapeutic choice...
March 11, 2024: Hämostaseologie
https://read.qxmd.com/read/38465696/differentiating-electrocardiographic-indications-of-massive-and-submassive-pulmonary-embolism-a-cross-sectional-study-in-southern-iran-from-2015-to-2020
#23
JOURNAL ARTICLE
Zahra Bahreini, Maliheh Kamali, Fatemeh Kheshty, Hamed Bazrafshan Drissi, Shahrokh Sadeghi Boogar, Mehdi Bazrafshan
BACKGROUND: Although using electrocardiogram (ECG) for pulmonary embolism (PE) risk stratification has shown mixed results, it is currently used as supplementary evidence in risk stratification. This cross-sectional study aimed to assess and compare ECG findings of massive and submassive PE versus segmental PE. METHODS: This cross-sectional study included 250 hospitalized patients with a confirmed diagnosis of acute PE from 2015 to 2020 in Southern Iran. Demographic variables, clinical data, troponin levels, on-admission ECG findings, echocardiography findings, and ECG findings 24 h after receiving anticoagulants or thrombolytics were extracted...
March 2024: Clinical Cardiology
https://read.qxmd.com/read/38464802/quadri-chamber-thrombi-and-impending%C3%A2-paradoxical-embolism-thrombus-in-transit-through-patent-foramen-ovale
#24
Samier Deen, Paul Gilbert, Kush Agrawal, Abby Borhan
Thrombus-in-transit through patent foramen ovale (PFO) is an extremely rare diagnosis that can often be associated with pulmonary embolism. Currently, data exists to guide management options; however, there is no medical consensus with regard to the optimal treatment strategy for thrombus-in-transit through PFO.
March 6, 2024: JACC. Case reports
https://read.qxmd.com/read/38464464/efficient-management-of-pulmonary-embolism-diagnosis-using-a-two-step-interconnected-machine-learning-model-based-on-electronic-health-records-data
#25
JOURNAL ARTICLE
Soroor Laffafchi, Ahmad Ebrahimi, Samira Kafan
Pulmonary Embolism (PE) is a life-threatening clinical disease with no specific clinical symptoms and Computed Tomography Angiography (CTA) is used for diagnosis. Clinical decision support scoring systems like Wells and rGeneva based on PE risk factors have been developed to estimate the pre-test probability but are underused, leading to continuous overuse of CTA imaging. This diagnostic study aimed to propose a novel approach for efficient management of PE diagnosis using a two-step interconnected machine learning framework directly by analyzing patients' Electronic Health Records data...
December 2024: Health Information Science and Systems
https://read.qxmd.com/read/38463704/intraoperative-cardiac-arrest-during-liposuction-a-case-report
#26
JOURNAL ARTICLE
Lu Shu, Jian Zhou, Xue He
BACKGROUND: With the popularity of liposuction surgery, more awareness should be obtained regarding complications. Liposuction has been thought of as a safe procedure with a very low incidence of major complications. However, life-threatening risks of liposuction have rarely been reported. METHODS: We present a case of a 36-year-old woman who developed cardiac arrest during a liposuction procedure, and we present a literature review. RESULTS: She was previously healthy and had no risk factors for pulmonary embolism...
March 2024: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/38462535/home-treatment-for-active-cancer-patients-with-low-risk-pulmonary-embolism%C3%A3-a-predetermined-companion-report-from-the-onco-pe-trial
#27
JOURNAL ARTICLE
Ryuki Chatani, Yugo Yamashita, Takeshi Morimoto, Nao Muraoka, Wataru Shioyama, Tatsuhiro Shibata, Yuji Nishimoto, Yoshito Ogihara, Kosuke Doi, Maki Oi, Taro Shiga, Daisuke Sueta, Kitae Kim, Yasuhiro Tanabe, Norimichi Koitabashi, Takuma Takada, Satoshi Ikeda, Hitoshi Nakagawa, Takayuki Mitsuhashi, Masaaki Shoji, Jiro Sakamoto, Shinji Hisatake, Yutaka Ogino, Masashi Fujita, Naohiko Nakanishi, Tomohiro Dohke, Seiichi Hiramori, Ryuzo Nawada, Kazuhisa Kaneda, Kazunori Mushiake, Hiromi Yamamoto, Kazushige Kadota, Koh Ono, Takeshi Kimura
BACKGROUND: Patients with appropriately selected low-risk pulmonary embolism (PE) can be treated at home, although it has been controversial whether applies to patients with cancer, who are considered not to be at low risk.Methods and Results: The current predetermined companion report from the ONCO PE trial evaluated the 3-month clinical outcomes of patients with home treatment and those with in-hospital treatment. The ONCO PE trial was a multicenter, randomized clinical trial among 32 institutions in Japan investigating the optimal duration of rivaroxaban treatment in cancer-associated PE patients with a score of 1 using the simplified version of the Pulmonary Embolism Severity Index (sPESI)...
March 8, 2024: Circulation Journal: Official Journal of the Japanese Circulation Society
https://read.qxmd.com/read/38461446/design-and-performance-analysis-of-a-new-inferior-vena-cava-filter
#28
JOURNAL ARTICLE
Xianying Wang, Huajie Wang, Hongliang Qian, Hongdong Su, Deda Lou, Lijian Tian, Deshen Chen, Huafang Ding, Feng Fan
This study proposes a novel inferior vena cava filter (IVCF) design, "Lotus," aiming to enhance release stability and endothelialization. A catheter-filter-vessel model was established for IVCF property analysis, validated by comparing numerical simulations and in vitro tests. Lotus's mechanical properties were analyzed, and optimization suggestions are provided. Compared to existing clinical filters, Lotus demonstrates improved release stability and thrombus capture ability. This work suggests Lotus as a potential technical reference for improved IVCF treatment...
March 10, 2024: Computer Methods in Biomechanics and Biomedical Engineering
https://read.qxmd.com/read/38458430/antithrombotic-therapy-for-vte-disease-compendium-and-review-of-chest-guidelines-2012-2021
#29
REVIEW
Scott M Stevens, Scott C Woller, Lisa Baumann Kreuziger, Kevin Doerschug, Geert-Jan Geersing, Frederikus A Klok, Christopher S King, Susan Murin, Janine R E Vintch, Philip S Wells, Suman Wasan, Lisa K Moores
The CHEST Antithrombotic Therapy for Venous Thromboembolism Disease evidencebased guidelines are now updated in a more frequent, focused manner. Guidance statements from the most recent full guideline and two subsequent updates have not been gathered into a single source. METHODS An international panel of experts with experience in prior Antithrombotic Therapy guideline development reviewed the 2012 CHEST Antithrombotic Therapy guideline and its two subsequent updates. All guideline statements, and their associated Patient, Intervention, Comparator, Outcome questions were assembled...
March 6, 2024: Chest
https://read.qxmd.com/read/38457560/pulmonary-thromboembolism-associated-with-hereditary-antithrombin-iii-deficiency-a-case-report
#30
JOURNAL ARTICLE
Jingwei Liu, Yin Wang, Chunyan Rong, Baoguo Wang, Xuhan Liu, Weihua Zhang
BACKGROUND: Thrombophilia is a coagulation disorder closely associated with venous thromboembolism. Hereditary antithrombin III (AT III) deficiency is a type of genetic thrombophilia. In China, genetic thrombophilia patients mainly suffer from deficiencies in AT III, protein S, and protein C. Multiple mutations in the serpin family C member 1 (SERPINC1) can affect AT III activity, resulting in thrombosis. CASE PRESENTATION: This case presented a 17-year-old adolescent female who developed lower extremity venous thrombosis and subsequently pulmonary embolism (PE) following a right leg injury...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456168/ovarian-vein-and-inferior-vena-cava-thrombosis-after-vaginal-delivery-a-case-report
#31
Hounaida Mahfoud, Amina Etber, Khadija Errmili, Saad Khairoun, Najia Zeraidi, Aziz Baidada
Ovarian vein thrombosis (OVT) is a rare but serious complication, most commonly occurring in the postpartum period. This article reports the case of a 40-year-old woman who presented 12 days after a normal vaginal delivery with fever and pelvic pain. An initial diagnosis of endometritis was made, and empiric antibiotic therapy was administered, but the fever persisted. An ultrasound scan was then done to rule out appendicitis, which revealed a thrombosis of the right ovarian vein extended to the inferior vena cava...
March 2024: Case Reports in Women's Health
https://read.qxmd.com/read/38454308/role-of-vena-cava-filter-in-the-prophylaxis-and-treatment-of-venous-thromboembolism-in-injured-adult-patients-a-systematic-review-meta-analysis-and-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma
#32
JOURNAL ARTICLE
Bishwajit Bhattacharya, Lisa Kodadek, Igor Nichiporenko, Shawna Morrissey, Jordan Kirsch, Jeff Choi, Husayn Ladhani, George Kasotakis, Kaushik Mukherjee, Chaitan Narsule, Rahul Sharma, Lucy Ruangvoravat, Jeremy Grushka, Rishi Rattan, Nikolay Bugaev
BACKGROUND: Injured patients are at an increased risk of developing deep vein thrombosis (DVT) and pulmonary embolism (PE). Inferior vena cava (IVC) filters have been used in injured patients to prevent venous thromboembolism (VTE), but current evidence-based guidelines are lacking. METHODS: Questions regarding IVC filter use in injured patients with clearly defined Population(s), Intervention(s), Comparison(s), and appropriately selected Outcomes (PICO) were formulated...
March 8, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38450477/status-and-future-directions-for-balloon-pulmonary-angioplasty-in-chronic-thromboembolic-pulmonary-disease-with-and-without-pulmonary-hypertension-a-scientific-statement-from-the-american-heart-association
#33
REVIEW
Vikas Aggarwal, Jay Giri, Scott H Visovatti, Ehtisham Mahmud, Hiromi Matsubara, Michael Madani, Frances Rogers, Deepa Gopalan, Kenneth Rosenfield, Vallerie V McLaughlin
Balloon pulmonary angioplasty continues to gain traction as a treatment option for patients with chronic thromboembolic pulmonary disease with and without pulmonary hypertension. Recent European Society of Cardiology guidelines on pulmonary hypertension now give balloon pulmonary angioplasty a Class 1 recommendation for inoperable and residual chronic thromboembolic pulmonary hypertension. Not surprisingly, chronic thromboembolic pulmonary hypertension centers are rapidly initiating balloon pulmonary angioplasty programs...
March 7, 2024: Circulation
https://read.qxmd.com/read/38449913/preventive-hyperbaric-oxygen-therapy-for-asymptomatic-left-ventricular-air-during-ct-guided-lung-needle-biopsy
#34
Natsuki Kondo, Shinya Suzuki
Lung needle biopsy can cause air to enter the vessels due to the traffic between the vessels and the trachea. Hyperbaric oxygen therapy (HBOT) according to the U.S. Navy Treatment Table (USNTT) 6 or 6A protocol is used for arterial gas embolism (AGE). However, no treatment or HBOT protocol for asymptomatic intra-arterial air has been established. Here we report two cases of asymptomatic intra-arterial air during lung needle biopsy that were preventively treated with HBOT according to the USNTT 5 protocol. In case 1, a 72-year-old man with malignant lymphoma in remission underwent computed tomography (CT)-guided lung needle biopsy of a nodule in his right lung...
March 2024: Curēus
https://read.qxmd.com/read/38448797/one-year-outcomes-of-pulmonary-vein-isolation-with-a-novel-cryoballoon-primary-results-of-the-frozen-af-trial
#35
JOURNAL ARTICLE
Kenneth A Ellenbogen, Suneet Mittal, Niraj Varma, Arash Aryana, Nassir Marrouche, Ante Anić, Devi Nair, Jean Champagne, Saverio Iacopino, Carlo de Asmundis, Stanislav Weiner, Kevin Makati, Jonathan D Raybuck, Elizabeth Richards, Wilber Su
INTRODUCTION: Cryoablation therapy for pulmonary vein isolation (PVI) to treat paroxysmal atrial fibrillation (PAF) is well established. A novel 28 mm cryoballoon system designed to operate under low pressure to safely reach a lower nadir temperature and maintain constant balloon size during cooling has not been prospectively studied in a large patient population for safety and efficacy. The FROZEN AF (NCT04133168) trial was an international multicenter, open-label, prospective, single-arm study on the safety and performance of a novel cryoballoon system for treatment of PAF...
March 6, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38448659/an-intelligent-dna-nanodevice-for-precision-thrombolysis
#36
JOURNAL ARTICLE
Jue Yin, Siyu Wang, Jiahui Wang, Yewei Zhang, Chunhai Fan, Jie Chao, Yu Gao, Lianhui Wang
Thrombosis is a leading global cause of death, in part due to the low efficacy of thrombolytic therapy. Here, we describe a method for precise delivery and accurate dosing of tissue plasminogen activator (tPA) using an intelligent DNA nanodevice. We use DNA origami to integrate DNA nanosheets with predesigned tPA binding sites and thrombin-responsive DNA fasteners. The fastener is an interlocking DNA triplex structure that acts as a thrombin recognizer, threshold controller and opening switch. When loaded with tPA and intravenously administrated in vivo, these DNA nanodevices rapidly target the site of thrombosis, track the circulating microemboli and expose the active tPA only when the concentration of thrombin exceeds a threshold...
March 6, 2024: Nature Materials
https://read.qxmd.com/read/38447954/the-diagnostics-and-management-of-bronchopulmonary-sequestration-an-international-survey-among-specialized-caregivers
#37
JOURNAL ARTICLE
C M Kersten, M D G Jansen, M J P Zuidweg, R M W H Wijnen, T B Krasemann, J M Schnater
BACKGROUND:  Our objective was to explore the treatment preferences for bronchopulmonary sequestration (BPS) among an international group of specialized caregivers. METHODS:  Sixty-three participants from 17 countries completed an online survey concerning the diagnostics, treatment, and follow-up. Recruitment took place among members of the Collaborative Neonatal Network for the first European Congenital Pulmonary Airway Malformation Trial Consortium and through the Association for European Pediatric and Congenital Cardiology working group database...
March 6, 2024: European Journal of Pediatric Surgery
https://read.qxmd.com/read/38446279/recurrent-icd-associated-l-monocytogenes-bacteraemia-with-multiple-septic-pulmonary-embolisms-over-a-2-year-period
#38
JOURNAL ARTICLE
Astrid Füszl, Stefanie Schindler, Florian Heger, Mateusz Markowicz, Alexander Indra, Ariane Pietzka, Patrick Hyden, Adriana Cabal, René R Wenzel
BACKGROUND: Listeria monocytogenes is a bacterial pathogen known for causing listeriosis, a foodborne illness with a wide spectrum of clinical presentations ranging from mild gastroenteritis to severe invasive disease, particularly affecting immunocompromised individuals, pregnant women, newborns, and the elderly. Successful treatment of patients with recurring listeria episodes due to colonised foreign material is often challenging, typically requiring a combination of antimicrobial treatment and surgical removal...
March 6, 2024: Infection
https://read.qxmd.com/read/38445261/case-report-concurrent-low-volume-subdural-hematoma-and-ipsilateral-ischemic-stroke-presenting-as-capsular-warning-syndrome-a-complex-case-with-anticoagulation-dilemma-and-dual-pathology
#39
Daniel Strahnen, Angeliki Stathi, Jürgen Beck, Roland Roelz, Ioannis Vasilikos
BACKGROUND: The simultaneous emergence of low-volume subdural hematoma and ipsilateral ischemic stroke in an atrial fibrillation patient who is under anticoagulation therapy is a rare and intricate clinical case. This report accentuates the diagnostic and treatment complexities associated with these consecutive neurological conditions. CASE PRESENTATION: An 83 years-old male patient initially presented with acute dyspnea, raising the suspicion of pulmonary embolism...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38444355/long-circulating-nanoparticles-as-passive-targeting-nanocarriers-for-the-treatment-of-thrombosis
#40
JOURNAL ARTICLE
Junyao Li, Keqiang Lu, Shaokai Sun, Juanjuan Peng, Lingzhi Zhao
Thrombosis is the major cause of cardiovascular diseases. Only a small subset of patients could benefit from thrombolytic therapy due to the high bleeding risk brought about by the repeated administration of thrombolytic drugs. Nanoparticles with targeting ligands have been developed as nanocarriers of thrombolytic drugs to deliver the drug to the thrombus through active targeting. However, the passive targeting effect of nanoparticles on the thrombus is yet to be investigated. Herein, we prepared silica cross-linked micelles (SCLMs) with a long blood circulation half-life as drug carriers to target the thrombus through passive targeting...
March 6, 2024: Nanoscale
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