keyword
https://read.qxmd.com/read/38546819/pe-ynet-a-novel-attention-based-multi-task-model-for-pulmonary-embolism-detection-using-ct-pulmonary-angiography-ctpa-scan-images
#1
JOURNAL ARTICLE
G R Hemalakshmi, M Murugappan, Mohamed Yacin Sikkandar, D Santhi, N B Prakash, A Mohanarathinam
Pulmonary Embolism (PE) has diverse manifestations with different etiologies such as venous thromboembolism, septic embolism, and paradoxical embolism. In this study, a novel attention-based multi-task model is proposed for PE segmentation and detection from Computed Tomography Pulmonary Angiography (CTPA) images. A Y-Net architecture is used to implement this model, which facilitates segmentation and classification jointly, improving performance and efficiency. It is leveraged with Multi Head Attention (MHA), which allows the model to focus on important regions of the image while suppressing irrelevant information, improving the accuracy of the segmentation and detection tasks...
March 28, 2024: Physical and engineering sciences in medicine
https://read.qxmd.com/read/38543209/radiofrequency-combined-with-intratumoral-immunotherapy-preclinical-results-and-safety-in-metastatic-colorectal-carcinoma
#2
JOURNAL ARTICLE
Johanne Seguin, Mostafa El Hajjam, Josette Legagneux, Sarah Diakhaby, Nathalie Mignet, Vincent Boudy, Balthazar Toussaint, Frederique Peschaud, Jean François Emile, Claude Capron, Robert Malafosse
Radiofrequency ablation (RFA) of cancer induces an anti-tumor immunity, which is insufficient to prevent recurrences. In mice, RFA-intratumoral immunotherapy by granulocyte-macrophage colony-stimulating factor (GM-CSF) and Bacillus Calmette-Guerin resulted in complete metastases regression. Infectious risk in human needs replacement of live vaccines. Intratumoral purified protein derivatives (PPD) have never been tested in digestive cancers, and the safety of intratumoral immunotherapy after RFA has not yet been validated in human models...
February 23, 2024: Pharmaceutics
https://read.qxmd.com/read/38542049/venous-thromboembolism-management-throughout-the-covid-19-era-addressing-acute-and-long-term-challenges
#3
JOURNAL ARTICLE
Maddalena Alessandra Wu, Alba Taino, Pietro Facchinetti, Valentina Rossi, Diego Ruggiero, Silvia Berra, Giulia Blanda, Nicola Flor, Chiara Cogliati, Riccardo Colombo
Background: COVID-19 increases the risk of venous thromboembolism (VTE) through a complex interplay of mechanisms collectively referred to as immunothrombosis. Limited data exist on VTE challenges in the acute setting throughout a dynamic long-term follow-up of COVID-19 patients compared to non-COVID-19 patients. The aim of the study was to investigate acute and long-term management and complications in VTE patients with and without COVID-19. Methods: A prospective, observational, single-center cohort study on VTE patients followed from the acute care stage until 24 months post-diagnosis...
March 21, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541986/inferior-vena-cava-filters-a-clinical-review-and-future-perspectives
#4
REVIEW
Raffaella Benedetti, Simone Marino, Flavio Tangianu, Davide Imberti
Anticoagulation represents the first line treatment for venous thromboembolism (VTE). However, inferior vena cava (IVC) filter insertion can be considered as a possible therapeutic strategy when anticoagulant therapy is contraindicated, to avoid embolization from the lower limbs to pulmonary circulation. Other possible indications are debated among experts. Both permanent and retrievable caval filters are available in clinical practice. Retrievable filters can be removed when no longer necessary, as their use may be indicated only for a limited amount of time...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541861/extra-corporeal-membrane-oxygenation-in-pregnancy
#5
REVIEW
Tatsiana Romenskaya, Yaroslava Longhitano, Aman Mahajan, Gabriele Savioli, Antonio Voza, Manfredi Tesauro, Christian Zanza
Extracorporeal membrane oxygenation (ECMO) is a cardiac or pulmonary function support system that is used in cases of refractory organ failure in addition to conventional treatment. Currently, Level I evidence is not yet available, which reflects improved outcomes with ECMO in pregnant women, the use in pregnancy should be indicated in selected cases and only in specialized centers. We searched articles in the most important scientific databases from 2009 until 31 December 2023 consulting also the site ClinicalTrials...
March 13, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38537371/renal-cell-carcinoma-with-massive-cavo-atrial-tumor-thrombus-leading-to-pulmonary-embolism-case-study-and-literature-review
#6
Omar Bellouki, Ilyas Soufiani, Imad Boualaoui, Ahmed Ibrahimi, Hachem El Sayegh, Yassine Nouini
INTRODUCTION: Renal cell carcinoma (RCC) occasionally involves the inferior vena cava (IVC), but intra-atrial extension is very rare, with the most dreaded complication being thrombi migration into pulmonary arteries. CASE PRESENTATION: A 52-year-old male with rheumatoid arthritis and a smoking history presented with dyspnea, weight loss, and a previous episode of hematuria. Echocardiography revealed an intra-atrial thrombus with signs of pulmonary embolism (PE)...
March 24, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38537300/decompression-illness-a-comprehensive-overview
#7
JOURNAL ARTICLE
Simon J Mitchell
Decompression illness is a collective term for two maladies (decompression sickness [DCS] and arterial gas embolism [AGE]) that may arise during or after surfacing from compressed gas diving. Bubbles are the presumed primary vector of injury in both disorders, but the respective sources of bubbles are distinct. In DCS bubbles form primarily from inert gas that becomes dissolved in tissues over the course of a compressed gas dive. During and after ascent ('decompression'), if the pressure of this dissolved gas exceeds ambient pressure small bubbles may form in the extravascular space or in tissue blood vessels, thereafter passing into the venous circulation...
March 31, 2024: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
https://read.qxmd.com/read/38532938/real-world-data-on-treatment-patterns-and-bleeding-in-cancer-associated-thrombosis-data-from-the-troll-registry
#8
JOURNAL ARTICLE
Zygimantas Zaboras, Camilla Tøvik Jørgensen, Andreas Stensvold, Heidi Hassel Pettersen, Aleksandra Galovic Grdinic, Sigrid Kufaas Brækkan, Waleed Ghanima, Mazdak Tavoly
Background  International guidelines are increasingly recommending direct oral anticoagulants (DOACs) as the first-line treatment for cancer-associated thrombosis (CAT). However, data regarding treatment patterns and adherence to guidelines in patients with CAT are scarce. Objectives  This study aimed to explore anticoagulant treatment patterns in patients with CAT and to calculate the incidence rates of bleeding events. Methods  Patients ≥18 years with active cancer and a first-time venous thromboembolism between 2005 and 2020 were identified through the Venous T hrombosis R egistry in Østf OL d Hospita L ...
January 2024: TH Open: Companion Journal to Thrombosis and Haemostasis
https://read.qxmd.com/read/38531171/efficacy-and-safety-of-mesenchymal-stem-cell-derived-microvesicles-in-mouse-inflammatory-arthritis
#9
JOURNAL ARTICLE
Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
OBJECTIVE: To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. METHODS: MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and serum C-reactive protein levels were measured...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531094/syringe-assisted-test-aspiration-with-mechanical-aspiration-thrombectomy-results-in-good-safety-and-short-term-outcomes-in-the-treatment-of-patients-with-deep-venous-thrombosis
#10
JOURNAL ARTICLE
Wanglong Li, Yichen Lin, Kunfeng Su, Fanggang Cai, Jinchi Zhang, Xiaoling Lai, Xiaoqi Zheng, Pingfan Guo, Xinhuang Hou, Yiquan Dai
OBJECTIVE: To evaluate the short-term outcomes and safety of syringe-assisted test-aspiration with mechanical aspiration thrombectomy in the treatment of deep venous thrombosis. METHODS: This was a single-center, retrospective study of hospitalized patients with iliofemoral and/or inferior vena caval deep venous thrombosis, excluding those with pulmonary embolism. We collected the following patient data from the electronic medical records: age, sex, provoked/unprovoked deep venous thrombosis, symptom duration, thrombosed segments, and the presence of a tumor, thrombophilia, diabetes, and/or iliac vein compression syndrome...
March 26, 2024: Vascular
https://read.qxmd.com/read/38530216/is-it-time-to-reappraise-for-black-box-warning-on-angiojet-rheolytic-thrombectomy-in-patients-with-pulmonary-embolism-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Cihangir Kaymaz, Barkın Kültürsay, Hacer Ceren Tokgöz, Aykun Hakgör, Berhan Keskin, Özgür Yaşar Akbal, Ayhan Tosun, Seda Tanyeri, Ahmet Sekban, Çağdaş Buluş, Şeyhmus Külahçıoğlu, Ali Karagöz, İbrahim Halil Tanboğa, Nihal Özdemir
BACKGROUND: AngioJet rheolytic thrombectomy (ART) system has been widely used as a catheter-directed treatment (CDT) method in acute pulmonary embolism (PE), however, there has been a controversy regarding the safety of its use. In this systematic review and meta-analysis, we evaluated the efficacy and safety outcomes of ART in patients with PE. METHODS: Our meta-analysis have been based on search in the MEDLINE, EMBASE, and Cochrane Library for studies published up to August 2022...
March 26, 2024: Anatolian Journal of Cardiology
https://read.qxmd.com/read/38527273/a-65-year-old-man-with-refractory-hemoptysis-associated-with-chronic-progressive-pulmonary-aspergillosis-who-failed-to-respond-to-combined-endobronchial-occlusion-and-bronchial-artery-embolization-a-case-report-and-literature-review
#12
REVIEW
Ryotaro Yoneoka, Kenichiro Takeda, Hajime Kasai, Toshihiko Sugiura, Kohei Shikano, Mitsuhiro Abe, Takuji Suzuki
BACKGROUND Hemoptysis due to airway hemorrhage is treated with hemostatic agents, bronchial artery embolization (BAE), or surgical resection. We present the case of a 65-year-old man with refractory hemoptysis associated with chronic progressive pulmonary aspergillosis (CPPA) who failed to respond to combined endobronchial occlusion (EBO) with endobronchial Watanabe spigot (EWS) and BAE. CASE REPORT A 63-year-old man was diagnosed with CPPA in the right upper lung and presented to our hospital 2 years later for hemoptysis at age 65...
March 13, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38526363/-a-case-of-right-heart-failure-when-it-is-not-pulmonary-embolism
#13
JOURNAL ARTICLE
Enrico Tadiello, Emma Zimelli, Giulia Urbani, Tommaso Hinna Danesi, Daniela Reghellin, Claudio Bilato
A 66-year-old patient with recent instrumental findings (echocardiogram, cardiac magnetic resonance imaging) of right ventricular failure was hospitalized due to worsening signs and symptoms of right heart failure, while waiting for diagnostic definition. Pulmonary computed tomography angiography revealed findings compatible with bilateral pulmonary thromboembolism involving the main pulmonary artery. Anticoagulant therapy was initiated with initial benefit, partial relief of symptoms, and moderate improvement in right ventricular function...
April 2024: Giornale Italiano di Cardiologia
https://read.qxmd.com/read/38525891/the-topos-study
#14
JOURNAL ARTICLE
Tim Sebastian, Stefano Barco, Davide Voci, Michael Lichtenberg, Oliver Schlager, Houman Jalaie, Rick de Graaf, Christian Erbel, Alexander Massmann, Marc Schindewolf, David Spirk
<b/> Background : We aimed to study the long-term safety and efficacy of oblique venous stents for post-thrombotic syndrome (PTS) with iliac vein compression. Patients and methods : In the multinational, prospective, single-arm TOPOS study, PTS patients scheduled for endovascular therapy with the sinus-Obliquus® stent and optional distal extension with the sinus-Venous® or sinus-XL Flex® stent were enrolled at eight European vascular centres between October 2016 and December 2020. The primary outcome was primary stent patency at 24 months, and secondary outcomes included the clinical course of PTS (Villalta score, revised Venous Clinical Severity Score [rVCSS], Visual Analog Scale [VAS] of pain), quality of life changes (Chronic Venous Insufficiency Quality of Life Questionnaire, CIVIQ-20), and device-related complications...
March 25, 2024: VASA. Zeitschrift Für Gefässkrankheiten
https://read.qxmd.com/read/38523721/endovascular-embolization-for-massive-hemoptysis-in-intralobar-pulmonary-sequestration-with-celiac-artery-supply-a-comprehensive-case-report
#15
Dinesh Chataut, Shailendra Katwal, Sundar Suwal, Ajit Thapa, Amrit Bhusal
Pulmonary sequestration (PS) is a rare congenital anomaly characterized by noncommunicative lung tissue supplied by an abnormal systemic vessel. We present a case of a 30-year-old male with intralobar PS, receiving arterial supply from the celiac artery, manifesting as massive hemoptysis. After urgent stabilization, endovascular embolization using polyvinyl alcohol particles was successfully employed. The patient's symptoms resolved, and follow-up confirmed satisfactory recovery. Our case underscores the diverse arterial origins of PS and the efficacy of endovascular embolization as a minimally invasive treatment...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38523696/ct-pulmonary-arteriogram-diagnosis-of-macroscopic-fat-embolism-to-the-lung
#16
Robert Murphy, Róisín A Murray, Sven O'hEireamhoin, John G Murray
Pulmonary fat embolism (PFE) is a recognised complication of long bone fractures. The majority of cases represent microscopic embolism and are not detectable at CT pulmonary arteriography (CTPA). CT can be used to detect macroscopic fat based on Hounsfield attenuation. This case describes a case of macroscopic fat embolism to the pulmonary arteries which was confidently diagnosed at CTPA. Distinction from thromboembolism is important as treatment is supportive and may avoid risks of anticoagulation.
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38523134/american-association-for-the-surgery-of-trauma-american-college-of-surgeons-committee-on-trauma-clinical-protocol-for-post-discharge-venous-thromboembolism-prophylaxis-after-trauma
#17
JOURNAL ARTICLE
Allison E Berndtson, Alisa Cross, Brian K Yorkgitis, Ryan Kennedy, Matthew P Kochuba, Christopher Tignanelli, Gail T Tominaga, David G Jacobs, Dennis W Ashley, Eric J Ley, Lena Napolitano, Todd W Costantini
Trauma patients are at an elevated risk for developing venous thromboembolism (VTE), which includes pulmonary embolism and deep vein thrombosis. In the inpatient setting, prompt pharmacologic prophylaxis is utilized to prevent VTE. For patients with lower extremity fractures or limited mobility, VTE risk does not return to baseline levels post-discharge. Currently, there are limited data to guide post-discharge VTE prophylaxis in trauma patients. The goal of these post-discharge VTE prophylaxis guidelines are to identify patients at the highest risk of developing VTE after discharge and to offer pharmacologic prophylaxis strategies to limit this risk...
March 25, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38518999/racial-disparities-and-other-socioeconomic-predictors-of-mortality-in-acute-pulmonary-embolism-treatment-from-the-national-inpatient-sample
#18
JOURNAL ARTICLE
Joseph A Breuer, K Hamzah Ahmed, Riley Scherr, Caitlyn Sing, Farouk Nouizi, Kenneth Nguyen Huynh, Gelareh Sadigh, Dinora Chinchilla, Nadine Abi-Jaoudeh
PURPOSE: To explore the significance of socioeconomic factors such as race and ethnicity as predictors of mortality in sub-massive and massive acute pulmonary embolism (PE). MATERIALS AND METHODS: Hospitalizations aged > 18 years with acute, non-septic PE from 2016 to 2019 were identified in the National Inpatient Sample and divided into IR (CDT and thrombectomy) and non-IR (tPA) treatments. Statistical analyses calculated significant odds ratios via 95% confidence intervals...
March 20, 2024: Journal of Vascular and Interventional Radiology: JVIR
https://read.qxmd.com/read/38511125/changes-in-pulmonary-vascular-resistance-and-obstruction-score-following-acute-pulmonary-embolism-in-pigs
#19
JOURNAL ARTICLE
Victor T Merit, Mathilde E Kirk, Jacob G Schultz, Jacob V Hansen, Mads D Lyhne, Anders D Kramer, Christina C E Pedersen, Lina Karout, Mannudeep K Kalra, Asger Andersen, Jens Erik Nielsen-Kudsk
OBJECTIVES: To investigate the contribution of mechanical obstruction and pulmonary vasoconstriction to pulmonary vascular resistance (PVR) in acute pulmonary embolism (PE) in pigs. DESIGN: Controlled, animal study. SETTING: Tertiary university hospital, animal research laboratory. SUBJECTS: Female Danish slaughter pigs ( n = 12, ~60 kg). INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: PE was induced by infusion of autologous blood clots in pigs...
February 2024: Critical care explorations
https://read.qxmd.com/read/38510955/paradoxical-pulmonary-artery-systolic-pressure-response-with-catheter-directed-therapies-for-pulmonary-embolism
#20
JOURNAL ARTICLE
Patrick Ho, Farouk Al-Chami, Mara Caroline, Eric Gnall, Joseph Bonn, Lee Greenspon
BACKGROUND: Early data on use of catheter-directed therapies (CDT) for treatment of Intermediate or High-Risk pulmonary embolism (PE) show improvement in pulmonary artery systolic pressures (PAsP) and RV/LV ratios. Occasionally a paradoxical rise in PAsP was observed with CDT utilizing ultrasound-assisted thrombolysis (USAT). It is unclear whether this pattern is seen with CDT utilizing mechanical aspiration. OBJECTIVES: To investigate and compare the changes in PAsP between those who underwent CDT with USAT to those with mechanical aspiration...
October 2023: American heart journal plus: cardiology research and practice
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