keyword
MENU ▼
Read by QxMD icon Read
search

Leak

keyword
https://www.readbyqxmd.com/read/29352041/stress-signaling-jnk2-crosstalk-with-camkii-underlies-enhanced-atrial-arrhythmogenesis
#1
Jiajie Yan, Weiwei Zhao, Justin K Thomson, Xianlong Gao, Dominic M DeMarco, Elena Carrillo, Biyi Chen, Xiaomin Wu, Kenneth S Ginsburg, Mamdouh Bakhos, Donald M Bers, Mark E Anderson, Long-Sheng Song, Michael Fill, Xun Ai
Rationale: Atrial fibrillation (AF) is the most common arrhythmia and advanced age is an inevitable and predominant AF risk factor. However, the mechanisms that couple aging and AF propensity remain unclear, making targeted therapeutic interventions unattainable. Objective: To explore the functional role of an important stress-response c-Jun N-terminal kinase (JNK) in sarcoplasmic reticulum (SR) Ca2+ handling and consequently Ca2+-mediated atrial arrhythmias. Methods and Results: We employed a series of cutting-edge electrophysiological and molecular techniques, exploited the power of transgenic mouse models to detail the molecular mechanism, and verified its clinical applicability in parallel studies on donor human hearts...
January 19, 2018: Circulation Research
https://www.readbyqxmd.com/read/29351939/retroperitoneal-bile-leak-after-laparoscopic-cholecystectomy
#2
Dee Zhen Lim, Enoch Wong, Sayed Hassen, Yahya Al-Habbal
Bile duct injury (BDI) is a well-recognised complication of laparoscopic cholecystectomy (LC). Following a BDI, bile usually leaks into the peritoneal space and causes biliary peritonitis. This manifests as non-specific abdominal pain and fever occurring several days after the surgery. It can be managed by laparoscopic washout with or without bile duct repair. We present a rare case of retroperitoneal bile leak post-LC. The mechanism of injury here was likely partial avulsion from excessive traction of the cystic duct during intraoperative cholangiogram...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351718/good-versus-good-enough-empirical-tests-of-methane-leak-detection-sensitivity-of-a-commercial-infrared-camera
#3
Arvind P Ravikumar, Jingfan Wang, Mike McGuire, Clay S Bell, Daniel Zimmerle, Adam R Brandt
Methane - a key component of natural gas - is a potent greenhouse gas. A key feature of recent methane mitigation policies is the use of periodic leak detection surveys, typically done with optical gas imaging (OGI) technologies. The most common OGI technology is an infrared camera. In this work, we experimentally develop detection probability curves for OGI-based methane leak detection under different environmental and imaging conditions. Controlled single blind leak detection tests show that the median detection limit (50% detection likelihood) for FLIR-camera based OGI technology is about 20 g CH4/h at an imaging distance of 6 m, an order of magnitude higher than previously reported estimates of 1...
January 19, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29351678/endoscopic-transcranial-duraplasty-for-rhinoliquorrhea-a-cadaveric-study
#4
Andrea Bartoli, Jean H Fasel, Karl Schaller, Max Jägersberg
BACKGROUND: Repair of the anterior skull base for cerebrospinal fluid leak requires either endoscopic endonasal approach or open transcranial approach. OBJECTIVE: To present a less invasive surgical procedure for sealing of the entire anterior fossa floor for traumatic rhinoliquorrhea. METHODS: Cadaver study in 3 head specimens. Endoscopic placement of a furled bovine pericardial patch bilaterally along the sphenoid ridge and planum in guidewire technique...
February 1, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29349542/laparoscopic-pancreaticoduodenectomy-with-reconstruction-of-the-mesentericoportal-vein-with-the-parietal-peritoneum-and-the-falciform-ligament
#5
Safi Dokmak, Béatrice Aussilhou, Mélanie Calmels, Houcine Maghrebi, Fadhel Samir Ftériche, Olivier Soubrane, Alain Sauvanet
BACKGROUND: With the improvement of the surgical technique of Laparoscopic pancreaticoduodenectomy (LPD), indications will be extended to patients with vascular invasion. With LPD, vascular grafts for reconstruction are more frequently needed because adequate mobilization is not always done and vascular grafts can safely facilitate reconstruction. We describe our experience of reconstruction with the falciform ligament. METHODS: Venous reconstruction is performed after removal of the specimen...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29348010/early-outcomes-with-the-evolut-pro-repositionable-self-expanding-transcatheter-aortic-valve-with-pericardial-wrap
#6
John K Forrest, Abeel A Mangi, Jeffrey J Popma, Kamal Khabbaz, Michael J Reardon, Neal S Kleiman, Steven J Yakubov, Daniel Watson, Susheel Kodali, Isaac George, Peter Tadros, George L Zorn, John Brown, Robert Kipperman, Sara Saul, Hongyan Qiao, Jae K Oh, Mathew R Williams
OBJECTIVES: This study sought to evaluate the Medtronic Evolut PRO Transcatheter Aortic Valve System in patients with severe symptomatic aortic stenosis. BACKGROUND: A next-generation self-expanding transcatheter aortic valve was designed with an external pericardial wrap with the intent to reduce paravalvular leak while maintaining the benefits of a low-profile, self-expanding, and repositionable supra-annular valve. METHODS: The Medtronic Evolut PRO Clinical Study included 60 patients undergoing transcatheter aortic valve replacement with the Evolut PRO valve at 8 investigational sites in the United States...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29348006/importance-of-contrast-aortography-with%C3%A2-lotus-transcatheter-aortic-valve-replacement-a-post-hoc-analysis-from-the-respond-post-market-study
#7
Lennart van Gils, Jochen Wöhrle, David Hildick-Smith, Sabine Bleiziffer, Daniel J Blackman, Mohamed Abdel-Wahab, Ulrich Gerckens, Stephen Brecker, Vinayak Bapat, Thomas Modine, Osama I Soliman, Andrey Nersesov, Dominic Allocco, Volkmar Falk, Nicolas M Van Mieghem
OBJECTIVES: The aim of this post hoc analysis from the RESPOND (Repositionable Lotus Valve System-Post-Market Evaluation of Real World Clinical Outcomes) post-market study was to assess the final implantation depth on the contrast aortogram after Lotus valve (Boston Scientific, Marlborough, Massachusetts) transcatheter aortic valve replacement (TAVR) and to correlate with permanent pacemaker implantation (PPI) and paravalvular leak (PVL). BACKGROUND: Contrast aortography allows for the assessment of implantation depth and PVL during and after TAVR...
January 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29346253/an-innovative-solution-for-prolonged-air-leaks-the-customized-endobronchial-silicone-blocker
#8
Ravindra M Mehta, Abhinav Singla, Rajani S Bhat, Rakesh Godara, Chakravarthi Lokanath, Michael Cutaia
BACKGROUND: Prolonged air leak (PAL) is a life-threatening condition that can present either as bronchopleural fistula, or alveolar-pleural fistula (APF). Although numerous bronchoscopic treatments are described, they are either expensive, not widely available in the developing world or have limited success. We describe our experience with a novel customized endobronchial silicone blocker (CESB) for PAL treatment. METHODS: This is a retrospective study of PAL patients who underwent CESB placement...
January 16, 2018: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/29344915/mechanistic-investigation-of-visible-light-driven-photocatalytic-inactivation-of-e-coli-by-ag-agcl-znfe2o4
#9
Akhanda Raj Upreti, Nirina Khadgi, Yi Li
In this study, photocatalytic inactivation of Escherichia coli was investigated over magnetic nanocomposite Ag-AgCl/ZnFe2O4. The nanocomposite demonstrated efficient photocatalytic activity by complete inactivation of the bacteria within 60 min of visible light irradiation. The anions HPO42- and SO42- were found to play the most important role in the inhibition of photocatalytic inactivation of E. coli. A systematic investigation of mechanism of photocatalytic bacterial inactivation was carried out based on cell membrane injury test, scanning electron microscopy (SEM) of bacterial morphology changes, Fourier transform infrared (FTIR) spectroscopy of E...
January 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29344912/capillary-leak-syndrome-as-a-complication-of-antibody-mediated-rejection-treatment-a-case-report
#10
Juan C Ramirez-Sandoval, Ricardo Varela-Jimenez, Luis E Morales-Buenrostro
We report a case of capillary leak that developed during treatment of antibody-mediated rejection in a kidney transplant recipient. A 53-year-old female transplant recipient experienced an increase in serum creatinine from 1.1 to 1.8 mg/dL. Antibody-mediated rejection was diagnosed by graft biopsy. She was treated with five plasmapheresis sessions (on alternate days with albumin replacement), five doses of immunoglobulin (5 g/dose at 100 mg/kg), a single dose of rituximab (500 mg), and four doses of bortezomib on days 1, 4, 7, and 10 (1...
January 17, 2018: CEN Case Reports
https://www.readbyqxmd.com/read/29344787/a-novel-fully-covered-double-bump-stent-for-staple-line-leaks-after-bariatric-surgery-a-retrospective-analysis
#11
Thomas C C Boerlage, Gerardus P M Houben, Marcel J M Groenen, Klaas van der Linde, Arnold W J M van de Laar, Marloes Emous, Paul Fockens, Rogier P Voermans
BACKGROUND: Staple line leakage after bariatric surgery can be treated by endoscopic placement of a self-expandable stent. The success rate of stent placement is generally high, but migration is a frequent adverse event that hampers successful treatment. The Niti-S Beta stent is a fully covered double-bump stent that was specifically designed to prevent migration. This study aimed to evaluate the effectiveness and adverse event rate of the Niti-S Beta stent. METHODS: A retrospective study was performed in three high-volume bariatric centers...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344562/endoscopic-ultrasound-guided-choledochoduodenostomy-using-partially-covered-self-expandable-metal-stent-in-patients-with-malignant-distal-biliary-obstruction-and-unsuccessful-ercp
#12
Praveer Rai, C R Lokesh, Amit Goel, Rakesh Aggarwal
Background and study aims : Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) is an alternative to percutaneous transhepatic biliary drainage (PTBD) for patients with malignant distal biliary obstruction in whom ERCP has failed. We studied technical success, clinical success, stent patency rate and occurrence of adverse events in patients undergoing EUS-CDS with partially-covered self-expanding metal stent (PCSEMS). Patients and methods : Medical records of consecutive patients with unresectable malignant distal biliary obstruction requiring biliary drainage who underwent EUS-CDS because of failure of attempt at ERCP were reviewed...
January 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29343862/angiotensin-ii-overstimulation-leads-to-an-increased-susceptibility-to-dilated-cardiomyopathy-and-higher-mortality-in-female-mice
#13
Sophie Mathieu, Nabil El Khoury, Katy Rivard, Pierre Paradis, Mona Nemer, Céline Fiset
Heart failure (HF) is associated with high mortality and affects men and women differently. The underlying mechanisms for these sex-related differences remain largely unexplored. Accordingly, using mice with cardiac-specific overexpression of the angiotensin II (ANGII) type 1 receptor (AT1R), we explored male-female differences in the manifestations of hypertrophy and HF. AT1R mice of both sexes feature electrical and Ca2+ handling alterations, systolic dysfunction, hypertrophy and develop HF. However, females had much higher mortality (21...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343759/incorporation-of-iloprost-in-phospholipase-resistant-phospholipid-scaffold-enhances-its-barrier-protective-effects-on-pulmonary-endothelium
#14
Olga Oskolkova, Nicolene Sarich, Yufeng Tian, Grzegorz Gawlak, Fanyong Meng, Valery N Bochkov, Evgeny Berdyshev, Anna A Birukova, Konstantin G Birukov
Correction of barrier dysfunction and inflammation in acute lung injury (ALI) represents an important problem. Previous studies demonstrate barrier-protective and anti-inflammatory effects of bioactive lipid prostacyclin and its stable analog iloprost (ILO). We generated a phospholipase resistant synthetic phospholipid with iloprost attached at the sn-2 position (ILO-PC) and investigated its biological effects. In comparison to free ILO, ILO-PC caused sustained endothelial cell (EC) barrier enhancement, linked to more prolonged activation of Rap1 and Rac1 GTPases and their cytoskeletal and cell junction effectors: cortactin, PAK1, p120-catenin and VE-cadherin...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343753/procalcitonin-as-a-biomarker-for-malignant-cerebral-edema-in-massive-cerebral-infarction
#15
Yan Zhang, Gang Liu, Yuan Wang, Yingying Su, Rehana K Leak, Guodong Cao
The objective of this study is to explore whether procalcitonin (PCT) can serve as an early biomarker of malignant cerebral edema in patients with massive cerebral infarction (MCI). Ninety-three patients with acute MCI were divided into death or survival groups based on whether they died or survived within 1 week of cerebral herniation. Differences in laboratory parameters between these two groups were analyzed by univariate analysis, followed by multivariate logistic regression analyses if the influencing factors were significantly different...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342487/-application-of-intrabronchial-valves-in-high-risk-patients-with-bronchopleural-fistula-an-alternative-therapeutic-option
#16
Ali Akil, Jan Reichelt, Stefan Freermann, Ilias Karfis, Michael Semik, Stefan Fischer
OBJECTIVES: Persistent air leak or bronchopleural fistula (BPF) is a challenging and frequently observed problem after pulmonary resection and may lead to prolonged chest tube therapy. One efficient nonsurgical approach to manage such a fistula is the application of intrabronchial valves. This may support earlier chest tube removal and hospital discharge. METHODS: Between 04/2015 and 03/2017, n = 8 patients (n = 4 female) with severe pleural empyema and necrotising lung tissue defects developed prolonged air leak and persistent BPF after surgery...
January 17, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29342438/vitreoretinal-complications-and-outcomes-in-92-eyes-undergoing-surgery-for-modified-osteo-odonto-keratoprosthesis-a-10-year-review
#17
Pukhraj Rishi, Ekta Rishi, Vishvesh Agarwal, Sridevi Nair, Geetha Iyer, Bhaskar Srinivasan, Shweta Agarwal
PURPOSE: To analyze vitreoretinal (VR) complications and treatment outcomes in eyes undergoing modified osteo-odonto-keratoprosthesis (OOKP) surgery. DESIGN: Retrospective case series. PARTICIPANTS: All patients who underwent modified OOKP (mOOKP) surgery at a tertiary eye-care center from March 2003 to February 2013 were included. METHODS: Medical records were reviewed for relevant medical history, best-corrected visual acuity (BCVA), slit-lamp examination, ultrasound scan, oral examination findings, and VR complications...
January 13, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29342033/meningoencephalocele-and-cerebrospinal-fluid-leak-complicating-orbital-decompression
#18
Liza M Cohen, Juan C Jiménez Pérez, Eric H Holbrook, William T Curry, Michael K Yoon
A 51-year-old man who had undergone right orbital decompression 5 months earlier developed a meningoencephalocele extending in the right sphenoid sinus through a skull base defect of the right ethmoid, sphenoid, and frontal bones. The authors report the third case to their knowledge of meningoencephalocele with cerebrospinal fluid leak after orbital decompression and discuss its management and measures that can be taken to prevent this rare but serious complication.
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29341818/medicine-as-it-should-be-teaching-team-and-teamwork-during-a-palliative-care-clerkship
#19
Barbara A Head, Christian Davis Furman, Andrew M Lally, Kimberly Leake, Mark Pfeifer
BACKGROUND: Interprofessional Education (IPE) is an important component of medical education. Rotations with palliative care interdisciplinary teams (IDTs) provide an optimal environment for IPE and teaching teamwork skills. OBJECTIVE: Our objective was to assess the learning of senior medical students during a palliative care rotation. DESIGN: A constant comparison method based on grounded theory was used in this qualitative study. SETTING/SUBJECTS: Senior medical students completed a semi-structured reflective writing exercise after a required one-week palliative care clerkship...
January 17, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29341699/emission-of-nonclassical-radiation-by-inelastic-cooper-pair-tunneling
#20
M Westig, B Kubala, O Parlavecchio, Y Mukharsky, C Altimiras, P Joyez, D Vion, P Roche, D Esteve, M Hofheinz, M Trif, P Simon, J Ankerhold, F Portier
We show that a properly dc-biased Josephson junction in series with two microwave resonators of different frequencies emits photon pairs in the resonators. By measuring auto- and intercorrelations of the power leaking out of the resonators, we demonstrate two-mode amplitude squeezing below the classical limit. This nonclassical microwave light emission is found to be in quantitative agreement with our theoretical predictions, up to an emission rate of 2 billion photon pairs per second.
September 29, 2017: Physical Review Letters
keyword
keyword
10883
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"