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https://www.readbyqxmd.com/read/29793207/infectivity-reduction-efficacy-of-uv-irradiation-and-peracetic-acid-uv-combined-treatment-on-ms2-bacteriophage-and-murine-norovirus-in-secondary-wastewater-effluent
#1
ShihChi Weng, Nathan Dunkin, Kellogg J Schwab, James McQuarrie, Kati Bell, Joseph G Jacangelo
Peracetic acid (PAA) is a strong oxidant/bactericide that has been applied in various industries (e.g., food processing, pharmaceuticals, medical device sterilization, etc.) as a disinfectant. There is increasing interest in using PAA for wastewater disinfection because it does not form halogenated byproducts, and no post-treatment quenching is required. Previous studies have demonstrated good efficiency in controlling bacteria in wastewater, but limited information is available for viruses, especially those hosted by mammals (e...
May 21, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29793186/excess-sludge-disruption-and-pollutant-removal-from-tannery-effluent-by-upgraded-activated-sludge-system
#2
Vijay Sodhi, Ajay Bansal, Mithilesh Kumar Jha
This study proposed a maintenance metabolism based upgraded activated sludge as MANODOX system that restricts excess biosludge generation from high strength real tannery effluent. The MANODOX experimental demonstration has been done using a sequenced operational arrangement of a MBBR, anaerobic digester, and oxidation ditch connected to CAS reactor, discussed in detail manner. Experimental trends revealed a prominently lower sludge yield upto 0.271 gVSS/gCOD (72% overall sludge reduction) that corresponds to parallel run CAS (0...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793182/healthcare-provider-counseling-to-quit-smoking-and-patient-desire-to-quit-the-role-of-negative-smoking-outcome-expectancies
#3
Joan S Tucker, Brian D Stucky, Maria Orlando Edelen, William G Shadel, David J Klein
AIMS: The U.S. Public Health Service Clinical Practice Guideline on treating tobacco use and dependence recommends providing advice to quit to every tobacco user seen in a healthcare setting. However, the mechanism through which counseling encourages patients to quit has not been adequately studied. This study tests whether the association between receiving healthcare provider counseling and desire to quit is accounted for by negative health and psychosocial outcome expectancies of smoking...
May 21, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29793180/insulin-is-a-potential-antioxidant-for-diabetes-associated-cognitive-decline-via-regulating-nrf2-dependent-antioxidant-enzymes
#4
Ying Song, Wei Ding, Yun Bei, Yan Xiao, Hai-Da Tong, Li-Bo Wang, Li-Yao Ai
PURPOSE: To investigate the neuroprotective effects of insulin on diabetic encephalopathy and its mechanism. EXPERIMENTAL AND APPROACH: The diabetic model was established by injection of streptozotocin. Behavior examinations were conducted by the Morris water maze. Histopathological alterations were detected by HE staining. ROS, CAT levels and SOD activity were measured using a microplate reader. In vitro, the viability of wild type and knock-down PC12 cells was detected by MTT assay, the morphology of cells was monitored under a microscope...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793179/nano-strategies-for-berberine-delivery-a-natural-alkaloid-of-berberis
#5
REVIEW
Elaheh Mirhadi, Mehdi Rezaee, Bizhan Malaekeh-Nikouei
Berberine, as a phytochemical component of some medicinal Chinese herbs (most frequently Berberis vulgaris), is an isoquinoline alkaloid with many therapeutic effects including anti-viral, anti-microbial, anti-diarrhea, anti-inflammatory and anti-tumor effects. Berberine has some significant effects on type 2 diabetes through adenosine monophosphate-activated protein kinase activation, glycolysis stimulation, and mitochondrial function inhibition which subsequently improves both lipid and glucose metabolism...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793177/long-noncoding-rna-gas5-suppresses-triple-negative-breast-cancer-progression-through-inhibition-of-proliferation-and-invasion-by-competitively-binding-mir-196a-5p
#6
Shuqin Li, Jun Zhou, Zhaoxin Wang, Peishun Wang, Xitao Gao, Yan Wang
Triple-negative breast cancer (TNBC) is considered to be the most aggressive and lethal type of breast cancer. Many studies have suggested that the dysfunction of long noncoding RNAs (lncRNAs) is correlated with breast cancer metastasis and progression. Here, we show that levels of the lncRNA, growth arrest-specific transcript 5 (GAS5), are decreased in TNBC tissues, and this down-regulation of GAS5 is associated with an aggressive tumor phenotype in patients, affecting clinical stage, lymph node metastasis and overall survival...
May 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29793175/apolipoprotein-ciii-and-n-terminal-prohormone-b-type-natriuretic-peptide-as-independent-predictors-for-cardiovascular-disease-in-type-2-diabetes
#7
Marco Colombo, Helen C Looker, Bassam Farran, Felix Agakov, M Julia Brosnan, Paul Welsh, Naveed Sattar, Shona Livingstone, Paul N Durrington, D John Betteridge, Paul M McKeigue, Helen M Colhoun
BACKGROUND AND AIMS: Developing sparse panels of biomarkers for cardiovascular disease in type 2 diabetes would enable risk stratification for clinical decision making and selection into clinical trials. We examined the individual and joint performance of five candidate biomarkers for incident cardiovascular disease (CVD) in type 2 diabetes that an earlier discovery study had yielded. METHODS: Apolipoprotein CIII (apoCIII), N-terminal prohormone B-type natriuretic peptide (NT-proBNP), high sensitivity Troponin T (hsTnT), Interleukin-6, and Interleukin-15 were measured in baseline serum samples from the Collaborative Atorvastatin Diabetes trial (CARDS) of atorvastatin versus placebo...
May 21, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29793163/rheological-characterisation-of-concentrated-domestic-slurry
#8
A K Thota Radhakrishnan, J B van Lier, F H L R Clemens
The much over-looked element in new sanitation, the transport systems which bridge the source and treatment facilities, is the focus of this study. The knowledge of rheological properties of concentrated domestic slurry is essential for the design of the waste collection and transport systems. To investigate these properties, samples were collected from a pilot sanitation system in the Netherlands. Two types of slurries were examined: black water (consisting of human faecal waste, urine, and flushed water from vacuum toilets) and black water with ground kitchen waste...
May 3, 2018: Water Research
https://www.readbyqxmd.com/read/29793158/botulinum-toxin-type-a-affects-mechanics-of-non-injected-antagonistic-rat-muscles
#9
Filiz Ateş, Can A Yucesoy
Botulinum toxin type A (BTX-A) effects on the mechanics of non-injected antagonistic muscles are unknown. The aim was to test the following hypotheses in a rat model: BTX-A injected into gastrocnemius medialis (GM) and lateralis (GL) (1) decreases forces of the antagonistic tibialis anterior (TA) and extensor digitorum longus (EDL), (2) reduces length range of force exertion and (3) increases passive forces of the TA, and (4) changes inter-antagonistic and inter-synergistic epimuscular myofascial force transmission (EMFT)...
May 17, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793139/the-use-of-low-intensity-pulsed-ultrasound-in-treating-delayed-union-of-fifth-metatarsal-fractures
#10
Kar Hao Teoh, Robert Whitham, Jenny F Wong, Kartik Hariharan
BACKGROUND: There are no studies looking at the success rate of low-intensity pulsed ultrasound (LIPUS) in fifth metatarsal fracture delayed unions to our knowledge. The aim of this study is to investigate the use of LIPUS treatment for delayed union of fifth metatarsal fractures. METHODS: A retrospective review of patients who were treated with LIPUS following a delayed union of fifth metatarsal fracture was conducted over a three-year period. RESULTS: There were thirty patients (9 males, 21 females) in this cohort...
January 31, 2018: Foot
https://www.readbyqxmd.com/read/29793136/effects-of-gestational-hypertension-and-pre-eclampsia-in-mrna-expression-of-fibrinolysis-genes-in-primary-cultured-human-umbilical-vein-endothelial-cells
#11
Irais Poblete-Naredo, Yury Rodríguez-Yáñez, Rogelio O Corona-Núñez, Stuart González-Monroy, Juan E Salinas, Arnulfo Albores
Hypertension disorders (HD) and pre-eclampsia (PRE) are leading causes of maternal deaths worldwide. PRE is associated with vascular endothelial dysfunction and with deregulation of the fibrinolysis pathway genes. Fibrinolysis is the fibrin clot hydrolysis process catalyzed by plasmin, a proteolytic enzyme formed from plasminogen. Plasminogen is cleaved by tissue-type (tPA) and urokinase-type (uPA) activators and inhibited by the plasminogen activator inhibitors type-1 (PAI-1) and type-2 (PAI-2). The whole process maintains blood hemostasis...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29793135/accuracy-of-magnetic-resonance-venography-in-diagnosing-cerebral-venous-sinus-thrombosis
#12
Liansheng Gao, Weilin Xu, Tao Li, Xiaobo Yu, Shenglong Cao, Hangzhe Xu, Feng Yan, Gao Chen
OBJECTIVES: The non-specific clinical manifestations and lack of effective diagnostic techniques have made cerebral venous sinus thrombosis (CVST) difficult to recognize and easy to misdiagnose. Several studies have suggested that different types of magnetic resonance venography (MRV) have advantages in diagnosing CVST. We conducted this meta-analysis to assess the accuracy of MRV in identifying CVST. MATERIAL AND METHODS: We searched the Embase, PubMed, and Chinese Biomedical (CBM) databases comprehensively to retrieve eligible articles up to Mar 31, 2018...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29793132/ph-responsive-label-assisted-click-chemistry-triggered-sensitivity-amplification-for-ultrasensitive-electrochemical-detection-of-carbohydrate-antigen-24-2
#13
Yun Zheng, Lihua Zhao, Zhanfang Ma
Sensitivity amplification strategy by implementing click chemistry in the construction of biosensing interface can efficiently improve the performance of immunosensor. Herein, we developed a sandwich-type amperometric immunosensor for ultrasensitive detection of carbohydrate antigen 24-2 (CA 242) based on pH responsive label-assisted click chemistry triggered sensitivity amplification strategy. The sensitivity of amperometric immunosensor relies on the current response differences (ΔI) caused by per unit concentration target analyte...
May 15, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29793114/soil-types-influence-the-fate-of-antibiotic-resistant-bacteria-and-antibiotic-resistance-genes-following-the-land-application-of-sludge-composts
#14
Junya Zhang, Qianwen Sui, Juan Tong, Hui Zhong, Yawei Wang, Meixue Chen, Yuansong Wei
Sewage sludge was generally considered a significant reservoir of antibiotic resistance genes (ARGs) and could enter agricultural systems as fertilizer after composting. Soil types and the discrepancy of sludge composts could have influenced the fate of antibiotic-resistant bacteria (ARB) following the land application of sludge composts, which deserved to be clarified. Thus, the fate of ARB and ARGs following the land application of three types of sludge composts (A, B, and C) to three different soils (red soil, loess, and black soil) was investigated...
May 21, 2018: Environment International
https://www.readbyqxmd.com/read/29793113/assessment-of-the-risk-of-antiangiogenic-agents-before-and-after-surgery
#15
REVIEW
Christina E Bailey, Alexander A Parikh
Angiogenesis plays a critical role in the growth, progression, and metastasis of numerous solid tumor types, and thus, antiangiogenic agents have been studied for many years as potential therapeutic agents. Many different antiangiogenic agents, including monoclonal antibodies and multi-targeted tyrosine kinase inhibitors (TKIs), have been approved for various oncology indications, and promising clinical activity has been demonstrated. However, some of these agents have also been associated with serious safety concerns...
May 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29793109/17%C3%AE-estradiol-as-precursors-of-cl-br-dbps-in-the-disinfection-process-of-different-water-samples
#16
Yanan Shao, Zihan Pan, Chuan Rong, Yinghui Wang, Hongxiang Zhu, Yuanyuan Zhang, Kefu Yu
During chlorine disinfection process, reactions between the disinfectant and 17β-estradiol (E2) lead to the formation of halogenated disinfection byproducts (DBPs) which can be a risk to both ecosystem and human health. The degradation and transformation products of E2 in sodium hypochlorite (NaClO) disinfection processes of different water samples were investigated. The reaction kinetics research showed that the degradation rates of E2 were considerably dependent on the initial pH value and the types of water samples...
May 21, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29793096/segmentation-of-histological-images-and-fibrosis-identification-with-a-convolutional-neural-network
#17
Xiaohang Fu, Tong Liu, Zhaohan Xiong, Bruce H Smaill, Martin K Stiles, Jichao Zhao
Segmentation of histological images is one of the most crucial tasks for many biomedical analyses involving quantification of certain tissue types, such as fibrosis via Masson's trichrome staining. However, challenges are posed by the high variability and complexity of structural features in such images, in addition to imaging artifacts. Further, the conventional approach of manual thresholding is labor-intensive, and highly sensitive to inter- and intra-image intensity variations. An accurate and robust automated segmentation method is of high interest...
May 16, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29793095/sex-hormones-affect-acute-and-chronic-stress-responses-in-sexually-dimorphic-patterns-consequences-for-depression-models
#18
Lei Guo, Yi-Xi Chen, Yu-Ting Hu, Xue-Yan Wu, Yang He, Juan-Li Wu, Man-Li Huang, Matthew Mason, Ai-Min Bao
BACKGROUND: Alterations in peripheral sex hormones may play an important role in sex differences in terms of stress responses and mood disorders. It is not yet known whether and how stress-related brain systems and brain sex steroid levels fluctuate in relation to changes in peripheral sex hormone levels, or whether the different sexes show different patterns. We aimed to investigate systematically, in male and female rats, the effect of decreased circulating sex hormone levels following gonadectomy on acute and chronic stress responses, manifested as changes in plasma and hypothalamic sex steroids and hypothalamic stress-related molecules...
May 21, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29793090/anti-haemostatic-compounds-from-the-vampire-snail-cumia-reticulata-molecular-cloning-and-in-silico-structure-function-analysis
#19
Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo Mariottini, Manuela Cervelli
Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action...
May 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29793084/subthreshold-depression-among-diabetes-patients-in-beijing-cross-sectional-associations-among-sociodemographic-clinical-and-behavior-factors
#20
Dandan Wang, Lintao Shi, Leling Li, Xiaohui Guo, Yufeng Li, Yuan Xu, Shinan Yin, Qiaozhen Wu, Yu Yang, Xiaoming Zhuang, Yingli Gai, Quanmin Li, Yanjun Liu
BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants completed the Patient Health Questionnaire 9-item (PHQ-9) to evaluate depressive status, with scores between 5 and 14 considered SubD. Conditional logistic regression was conducted to investigate the variables associated with SubD in T2DM patients...
May 18, 2018: Journal of Affective Disorders
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