Shinichiro Maki, Md Shafiqul Islam, Tomohito Itoh, Masanobu Nurimoto, Akira Yabuki, Yu Furusawa, Hiroaki Kamishina, Yui Kobatake, Tofazzal Md Rakib, Martia Rani Tacharina, Osamu Yamato
Canine degenerative myelopathy (DM) is an adult-onset, chronic, progressive neurodegenerative disease reported in multiple canine breeds, including the German Shepherd Dog (GSD). Clinical signs include progressive motor neuron paralysis, which begins in the pelvic limbs and eventually leads to respiratory distress, which may necessitate euthanasia. A common DM-associated mutation is a single nucleotide substitution that causes an amino acid substitution (c.118G>A, p.E40K) in the canine SOD1 gene. This SOD1 mutation and the clinical progression rate of A/A risk genotype in the Japanese GSD population have not been analyzed before...
June 27, 2022: Animals: An Open Access Journal From MDPI