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Canine myelopathy

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https://www.readbyqxmd.com/read/27917507/evidence-of-a-genomic-insertion-in-intron-2-of-sod1-causing-allelic-drop-out-during-routine-diagnostic-testing-for-canine-degenerative-myelopathy
#1
M E Turba, R Loechel, E Rombolà, G Gandini, F Gentilini
Degenerative myelopathy is a severe and progressive neurodegenerative disease and, in the majority of breeds, is associated with the c.118G>A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene. Our laboratories have been engaged in determining the cause of many discordant findings between the parental and the offspring genotypes found by different laboratories. In both cases, the discordant findings refer to actual heterozygous dogs that had been typed as homozygous for the variant allele...
December 4, 2016: Animal Genetics
https://www.readbyqxmd.com/read/27723239/spinal-mast-cell-tumors-in-dogs-imaging-features-and-clinical-outcome-of-four-cases
#2
Trevor W Moore, R Timothy Bentley, Sarah A Moore, Michele Provencher, Emma E Warry, Rebecca Kohnken, Hock Gan Heng
Published information regarding canine vertebral column mast cell tumors (MCTs) is limited. The objectives of this study were to report clinical and advanced imaging findings for a group of dogs with confirmed spinal MCT. Inclusion criteria for this retrospective case series were dogs with spinal magnetic resonance imaging (MRI) or computed tomography (CT) scans and a histological diagnosis of spinal MCT. Clinical, imaging, treatment, and outcome data were recorded. Four dogs met inclusion criteria. One dog had primary spinal MCT and three dogs had metastatic spinal MCT...
October 9, 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27682506/clinical-characteristics-of-canine-fibrocartilaginous-embolic-myelopathy-fce-a-systematic-review-of-393-cases-1973-2013
#3
K A Bartholomew, K E Stover, N J Olby, S A Moore
Fibrocartilaginous embolic myelopathy (FCE) is common in dogs; however, there is conflicting information in the veterinary literature regarding clinical characteristics and data on recovery in severe cases is sparse. A systematic review of canine FCE was performed to delineate the natural history of this disease. 322 previously reported cases and 71 previously unreported cases were identified for inclusion. Source publications were identified via PubMed central search and by references from review articles...
September 28, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27185954/variants-within-the-sp110-nuclear-body-protein-modify-risk-of-canine-degenerative-myelopathy
#4
Emma L Ivansson, Kate Megquier, Sergey V Kozyrev, Eva Murén, Izabella Baranowska Körberg, Ross Swofford, Michele Koltookian, Noriko Tonomura, Rong Zeng, Ana L Kolicheski, Liz Hansen, Martin L Katz, Gayle C Johnson, Gary S Johnson, Joan R Coates, Kerstin Lindblad-Toh
Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS). Most dogs that develop DM are homozygous for a common superoxide dismutase 1 gene (SOD1) mutation. However, not all dogs homozygous for this mutation develop disease. We performed a genome-wide association analysis in the Pembroke Welsh Corgi (PWC) breed comparing DM-affected and -unaffected dogs homozygous for the SOD1 mutation. The analysis revealed a modifier locus on canine chromosome 25...
May 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27109068/changes-in-respiratory-function-in-pembroke-welsh-corgi-dogs-with-degenerative-myelopathy
#5
Kanae Oyake, Yui Kobatake, Sanae Shibata, Hiroki Sakai, Miyoko Saito, Osamu Yamato, Kazuya Kushida, Sadatoshi Maeda, Hiroaki Kamishina
Canine degenerative myelopathy (DM) is characterized by progressive degeneration of the spinal cord. Although atrophic changes in the intercostal muscles were previously reported in the late stage of DM in Pembroke Welsh Corgis (PWCs), changes in respiratory function have not yet been examined. In the present study, we performed an arterial blood gas analysis and measured respiratory movements over progressive disease stages to document changes in respiratory function in DM-affected PWCs. We found that respiratory dysfunction progressed during the later stages of DM and correlated with a change in respiratory movement to the abdominal breathing pattern...
September 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26693480/effects-of-bee-venom-injections-at-acupoints-on-neurologic-dysfunction-induced-by-thoracolumbar-intervertebral-disc-disorders-in-canines-a-randomized-controlled-prospective-study
#6
RANDOMIZED CONTROLLED TRIAL
Li-Chuan Tsai, Yi-Wen Lin, Ching-Liang Hsieh
Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-inflammatory and analgesic effects. Injection of BV at acupoints has been widely used to treat clinical disorders including inflammation, pain, and arthritis. The current study was intended to determine whether BV injections at acupoints can enhance treatment of canine neurological dysfunction caused by IVDD...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26592800/imaging-diagnosis-vertebral-polyostotic-lymphoma-in-a-geriatric-dog
#7
Julie Kornder, Simon R Platt, Joe Eagleson, Marc Kent, Shannon P Holmes
A 9-year-old spayed female Scottish terrier presented with an 8-day history of progressive paraparesis. Neurological examination suggested a painful T3-L3 myelopathy. Multifocal uniform contrast-enhancing masses involving the vertebral bodies, pedicles, laminae, and spinous processes of two vertebrae and compressing the spinal cord were present on MRI. Fluoroscopic-guided fine needle aspiration of one of the vertebral lesions revealed a predominantly lymphoblastic population of cells compatible with a diagnosis of lymphoma...
July 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/26432396/canine-degenerative-myelopathy-a-model-of-human-amyotrophic-lateral-sclerosis
#8
REVIEW
Raffaele Nardone, Yvonne Höller, Alexandra C Taylor, Piergiorgio Lochner, Frediano Tezzon, Stefan Golaszewski, Francesco Brigo, Eugen Trinka
Canine degenerative myelopathy (CDM) represents a unique naturally occurring animal model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs, neuropathologic findings, and involvement of the superoxide dismutase 1 (SOD1) mutation. A definitive diagnosis can only be made postmortem through microscopic detection of axonal degeneration, demyelination and astroglial proliferation, which is more severe in the dorsal columns of the thoracic spinal cord and in the dorsal portion of the lateral funiculus...
February 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/26403185/a-preliminary-evaluation-of-the-reliability-of-a-modified-functional-scoring-system-for-assessing-neurologic-function-in-ambulatory-thoracolumbar-myelopathy-dogs
#9
Chung-Sheng Lee, R Timothy Bentley, Hsin-Yi Weng, Gert J Breur
BACKGROUND: The objective of this study was to develop and assess the reliability of a modified scoring system for evaluating the function of the two pelvic limbs separately, in ambulatory thoracolumbar myelopathy dogs. A previously established neurologic score scale for dogs with T3-L3 lesions was modified in order to provide a separate score for each pelvic limb. RESULTS: Seventeen ambulatory dogs with thoracolumbar myelopathies were evaluated. Using the new scale, two observers independently performed 22 observational gait analyses (OGAs) in ten dogs without videotape...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26401327/a-retrospective-study-of-the-prevalence-of-the-canine-degenerative-myelopathy-associated-superoxide-dismutase-1-mutation-sod1-c-118g%C3%A2-%C3%A2-a-in-a-referral-population-of-german-shepherd-dogs-from-the-uk
#10
Angela L Holder, James A Price, Jamie P Adams, Holger A Volk, Brian Catchpole
BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c...
2014: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/26198211/clinical-reasoning-in-canine-spinal-disease-what-combination-of-clinical-information-is-useful
#11
T J A Cardy, S De Decker, P J Kenny, H A Volk
Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the patient signalment, history and neurological examination that could suggest the most likely diagnoses with statistical significance. A retrospective study of 500 dogs referred to the Queen Mother Hospital for Animals before June 2012 for the investigation of spinal disease was performed...
August 15, 2015: Veterinary Record
https://www.readbyqxmd.com/read/26162235/accumulation-and-aggregate-formation-of-mutant-superoxide-dismutase-1-in-canine-degenerative-myelopathy
#12
S Nakamae, Y Kobatake, R Suzuki, T Tsukui, S Kato, O Yamato, H Sakai, M Urushitani, S Maeda, H Kamishina
Canine degenerative myelopathy (DM) is an adult-onset progressive neurodegenerative disorder that has recently been linked to mutations in the superoxide dismutase 1 (SOD1) gene. We generated a polyclonal antibody against canine SOD1 to further characterize the mutant SOD1 protein and its involvement in DM pathogenesis. This antibody (SYN3554) was highly specific to canine SOD1 and had the ability to reveal distinct cytoplasmic aggregates in cultured cells expressing canine mutant SOD1 and also in the spinal neurons of symptomatic homozygotes...
September 10, 2015: Neuroscience
https://www.readbyqxmd.com/read/26030213/proteomic-analysis-of-cerebrospinal-fluid-in-canine-cervical-spondylomyelopathy
#13
Paula Martin-Vaquero, Ronaldo C da Costa, Matthew J Allen, Sarah A Moore, Jeremy K Keirsey, Kari B Green
STUDY DESIGN: Prospective study. OBJECTIVE: To identify proteins with differential expression in the cerebrospinal fluid (CSF) from 15 clinically normal (control) dogs and 15 dogs with cervical spondylomyelopathy (CSM). SUMMARY OF BACKGROUND DATA: Canine CSM is a spontaneous, chronic, compressive cervical myelopathy similar to human cervical spondylotic myelopathy. There is a limited knowledge of the molecular mechanisms underlying these conditions...
May 1, 2015: Spine
https://www.readbyqxmd.com/read/25732177/expression-of-autophagy-related-proteins-in-the-spinal-cord-of-pembroke-welsh-corgi-dogs-with-canine-degenerative-myelopathy
#14
M Ogawa, K Uchida, O Yamato, K Mizukami, J K Chambers, H Nakayama
Canine degenerative myelopathy (DM) is a progressive neurodegenerative disease frequently found in Pembroke Welsh Corgi (PWC) dogs, and it has clinical and pathologic similarities to human amyotrophic lateral sclerosis. Autophagy is a major intracellular protein degradation system. Abnormalities of autophagy--resulting in cell death through mechanisms called type II programmed cell death--have recently been reported to occur in various neurodegenerative diseases, including amyotrophic lateral sclerosis. Thus, the distribution and expression levels of proteins involved in autophagy were examined in the spinal cords of 8 PWC dogs suffering from DM with superoxide dismutase mutation, 5 non-DM PWC dogs, and 6 Beagle dogs without neurologic signs...
November 2015: Veterinary Pathology
https://www.readbyqxmd.com/read/24965833/cytokine-concentrations-in-the-cerebrospinal-fluid-of-great-danes-with-cervical-spondylomyelopathy
#15
P Martin-Vaquero, R C da Costa, S A Moore, A C Gross, T D Eubank
BACKGROUND: Chronic inflammation is involved in the pathogenesis of human cervical spondylotic myelopathy and could also play a role in cervical spondylomyelopathy (CSM) in dogs. HYPOTHESIS/OBJECTIVES: That cerebrospinal fluid (CSF) cytokine concentrations would differ between clinically normal (control) and CSM-affected Great Danes (GDs), with affected GDs showing higher levels of inflammatory cytokines, such as interleukin (IL)-6 and monocyte chemoattractant protein-1/chemokine ligand 2 (MCP-1/CCL2)...
July 2014: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/24662024/quantitative-assessment-of-hsp70-il-1%C3%AE-and-tnf-%C3%AE-in-the-spinal-cord-of-dogs-with-e40k-sod1-associated-degenerative-myelopathy
#16
M C Lovett, J R Coates, Y Shu, M J Oglesbee, W Fenner, S A Moore
Inflammation is involved in the pathogenesis of many neurodegenerative diseases. Canine degenerative myelopathy (DM) is a progressive adult-onset neurodegenerative disease commonly associated with an E40K missense mutation in the SOD1 gene. DM has many similarities to some familial forms of human amyotrophic lateral sclerosis (ALS) and may serve as an important disease model for therapy development. Pro-inflammatory mediators such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and heat shock protein (hsp) 70 play a role in the pathogenesis of ALS...
May 2014: Veterinary Journal
https://www.readbyqxmd.com/read/24524809/breed-distribution-of-sod1-alleles-previously-associated-with-canine-degenerative-myelopathy
#17
R Zeng, J R Coates, G C Johnson, L Hansen, T Awano, A Kolicheski, E Ivansson, M Perloski, K Lindblad-Toh, D P O'Brien, J Guo, M L Katz, G S Johnson
BACKGROUND: Previous reports associated 2 mutant SOD1 alleles (SOD1:c.118A and SOD1:c.52T) with degenerative myelopathy in 6 canine breeds. The distribution of these alleles in other breeds has not been reported. OBJECTIVE: To describe the distribution of SOD1:c.118A and SOD1:c.52T in 222 breeds. ANIMALS: DNA from 33,747 dogs was genotyped at SOD1:c.118, SOD1:c.52, or both. Spinal cord sections from 249 of these dogs were examined. METHODS: Retrospective analysis of 35,359 previously determined genotypes at SOD1:c...
March 2014: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/24390315/degenerative-myelopathy-in-german-shepherd-dog-comparison-of-two-molecular-assays-for-the-identification-of-the-sod1-c-118g-a-mutation
#18
Maria Teresa Capucchio, Veronica Spalenza, Elena Biasibetti, Maria Teresa Bottero, Roberto Rasero, Alessandra Dalmasso, Paola Sacchi
Degenerative myelopathy (DM) is a late-onset, slowly progressive degeneration of spinal cord white matter which is reported primarily in large breed dogs. The missense mutation SOD1:c.118G>A is associated with this pathology in several dog breeds, including the German Shepherd Dog (GSD). The aims of the present study were to develop a tool for the rapid screening of the SOD1 mutation site in dogs and to evaluate the association of the polymorphism with DM in the German Shepherd breed. Two different techniques were compared: a minisequencing test and a real-time pcr allelic discrimination assay...
February 2014: Molecular Biology Reports
https://www.readbyqxmd.com/read/24375814/characterization-of-thoracic-motor-and-sensory-neurons-and-spinal-nerve-roots-in-canine-degenerative-myelopathy-a-potential-disease-model-of-amyotrophic-lateral-sclerosis
#19
Brandie R Morgan, Joan R Coates, Gayle C Johnson, G Diane Shelton, Martin L Katz
Canine degenerative myelopathy (DM) is a progressive, adult-onset, multisystem degenerative disease with many features in common with amyotrophic lateral sclerosis (ALS). As with some forms of ALS, DM is associated with mutations in superoxide dismutase 1 (SOD1). Clinical signs include general proprioceptive ataxia and spastic upper motor neuron paresis in pelvic limbs, which progress to flaccid tetraplegia and dysphagia. The purpose of this study was to characterize DM as a potential disease model for ALS...
April 2014: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/24043596/characterization-of-intercostal-muscle-pathology-in-canine-degenerative-myelopathy-a-disease-model-for-amyotrophic-lateral-sclerosis
#20
Brandie R Morgan, Joan R Coates, Gayle C Johnson, Alyssa C Bujnak, Martin L Katz
Dogs homozygous for missense mutations in the SOD1 gene develop a late-onset neuromuscular disorder called degenerative myelopathy (DM) that has many similarities to amyotrophic lateral sclerosis (ALS). Both disorders are characterized by widespread progressive declines in motor functions, accompanied by atrophic changes in the descending spinal cord tracts. Some forms of ALS are also associated with SOD1 mutations. In end-stage ALS, death usually occurs as a result of respiratory failure from severe functional impairment of respiratory muscles...
December 2013: Journal of Neuroscience Research
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