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Canine myelopathy

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https://www.readbyqxmd.com/read/28337816/vertebral-venous-system-abnormalities-identified-with-magnetic-resonance-imaging-in-sighthounds
#1
John C Vernon, Alexane Durand, Julien Guevar, Roberto José-López, Gawain Hammond, Catherine Stalin, Rodrigo Gutierrez-Quintana
In humans, abnormalities of the vertebral venous system are considered rare but significant causes of radiculopathy and myelopathy. Published information on abnormalities of the canine vertebral venous system is currently lacking. Aims of this retrospective descriptive study were to characterize magnetic resonance imaging (MRI) abnormalities of the vertebral venous system in a population of sighthounds, report prevalence of vertebral venous system abnormalities within that population and explore possible clinical significance...
March 23, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28267216/neurological-manifestations-in-dogs-naturally-infected-by-leishmania-infantum-descriptions-of-10-cases-and-a-review-of-the-literature
#2
REVIEW
A P Giannuzzi, M Ricciardi, A De Simone, F Gernone
In order to evaluate possible nervous system involvement in canine leishmaniasis, retrospective evaluation of all medical records of leishmaniotic dogs exhibiting neurological signs referred to our hospital over a 5-year period was performed. The records of 10 dogs were reviewed. Depending on the neuroanatomical localisation, the dogs underwent advanced diagnostic imaging, cerebrospinal fluid analysis, electrodiagnostic testing and histopathologic evaluations. The final neurological diagnosis was: meningoencephalitis (n=2), brain haemorrhagic stroke (n=1), haemorrhagic choroiditis (n=1), meningomyelitis (n=2), ischaemic myelopathy (n=1), polymyositis (n=2) and peripheral neuropathy (n=1)...
March 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/28186658/cerebrospinal-fluid-levels-of-phosphorylated-neurofilament-heavy-as-a-diagnostic-marker-of-canine-degenerative-myelopathy
#3
C M Toedebusch, M D Bachrach, V B Garcia, G C Johnson, M L Katz, G Shaw, J R Coates, M L Garcia
BACKGROUND: No definitive, antemortem diagnostic test for canine degenerative myelopathy (DM) is available. Phosphorylated neurofilament heavy (pNF-H) is a promising biomarker for nervous system diseases. HYPOTHESIS/OBJECTIVE: Cerebrospinal fluid (CSF) and serum pNF-H is a detectable biological marker for diagnosis of canine DM. ANIMALS: Fifty-three DM-affected, 27 neurologically normal, 7 asymptomatic at-risk, and 12 DM mimic dogs. METHODS: Archived CSF and serum pNF-H concentrations were determined by a commercially available ELISA...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28151550/canine-acute-cervical-myelopathy-hydrated-nucleus-pulposus-extrusion-or-intraspinal-discal-cysts
#4
Cristian Falzone
OBJECTIVE: To differentiate between hydrated nucleus pulposus extrusion and ventral intraspinal discal cysts in dogs. STUDY DESIGN: Prospective case series. ANIMALS: Twenty dogs with acute onset of cervical myelopathy due to hydrated nucleus pulposus extrusion or ventral intraspinal discal cysts. METHODS: Clinical and magnetic resonance (MR) imaging findings, outcome after surgical treatment, cytologic and histologic findings of compressive material were taken into account...
April 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28069688/up-regulation-of-cb2-receptors-in-reactive-astrocytes-in-canine-degenerative-myelopathy-a-disease-model-of-amyotrophic-lateral-sclerosis
#5
María Fernández-Trapero, Francisco Espejo-Porras, Carmen Rodríguez-Cueto, Joan R Coates, Carmen Pérez-Díaz, Eva de Lago, Javier Fernández-Ruiz
Targeting the CB2 receptor afforded neuroprotection in SOD1(G93A) mutant mice, a model of amyotrophic lateral sclerosis (ALS). The neuroprotective effects of CB2 receptors were facilitated by their up-regulation in the spinal cord in SOD1(G93A) mutant mice. Herein, we have investigated whether a similar CB2 receptor up-regulation, as well as parallel changes in other endocannabinoid elements, are evident in the spinal cord of dogs with degenerative myelopathy (DM), caused from mutations in the superoxide dismutase 1 gene (SOD1)...
January 9, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27941298/degenerative-myelopathy-in-the-collie-breed-a-retrospective-immunohistochemical-analysis-of-superoxide-dismutase-1-in-an-affected-rough-collie-and-a-molecular-epidemiological-survey-of-the-sod1-c-118g-a-mutation-in-japan
#6
Moeko Kohyama, Masato Kitagawa, Hiroaki Kamishina, Yui Kobatake, Akira Yabuki, Mariko Sawa, Shusaku Kakita, Osamu Yamato
Canine degenerative myelopathy (DM) is an adult-onset, progressive neurodegenerative disease that occurs in multiple dog breeds. A DM-associated mutation of the canine superoxide dismutase 1 (SOD1) gene, designated as c.118G>A (p.E40K), has been implicated as one of pathogenetic determinants of the disease in many breeds, but it remains to be determined whether the c.118G>A mutation is responsible for development or progression of DM in Collies. Previously, a Rough Collie was diagnosed clinically and histopathologically as having DM in Japan, suggesting the possibility that the Collie breed may be predisposed to DM due to the high frequency of c...
February 28, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27917507/evidence-of-a-genomic-insertion-in-intron-2-of-sod1-causing-allelic-drop-out-during-routine-diagnostic-testing-for-canine-degenerative-myelopathy
#7
M E Turba, R Loechel, E Rombolà, G Gandini, F Gentilini
Degenerative myelopathy is a severe and progressive neurodegenerative disease and, in the majority of breeds, is associated with the c.118G>A substitution in exon 2 of the canine superoxide dismutase 1 (SOD1) gene. Our laboratories have been engaged in determining the cause of many discordant findings between the parental and the offspring genotypes found by different laboratories. In both cases, the discordant findings refer to actual heterozygous dogs that had been typed as homozygous for the variant allele...
June 2017: Animal Genetics
https://www.readbyqxmd.com/read/27723239/spinal-mast-cell-tumors-in-dogs-imaging-features-and-clinical-outcome-of-four-cases
#8
Trevor W Moore, R Timothy Bentley, Sarah A Moore, Michele Provencher, Emma E Warry, Rebecca Kohnken, Hock Gan Heng
Published information regarding canine vertebral column mast cell tumors (MCTs) is limited. The objectives of this study were to report clinical and advanced imaging findings for a group of dogs with confirmed spinal MCT. Inclusion criteria for this retrospective case series were dogs with spinal magnetic resonance imaging (MRI) or computed tomography (CT) scans and a histological diagnosis of spinal MCT. Clinical, imaging, treatment, and outcome data were recorded. Four dogs met inclusion criteria. One dog had primary spinal MCT and three dogs had metastatic spinal MCT...
January 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/27682506/clinical-characteristics-of-canine-fibrocartilaginous-embolic-myelopathy-fce-a-systematic-review-of-393-cases-1973-2013
#9
K A Bartholomew, K E Stover, N J Olby, S A Moore
Fibrocartilaginous embolic myelopathy (FCE) is common in dogs; however, there is conflicting information in the veterinary literature regarding clinical characteristics and data on recovery in severe cases is sparse. A systematic review of canine FCE was performed to delineate the natural history of this disease. 322 previously reported cases and 71 previously unreported cases were identified for inclusion. Source publications were identified via PubMed central search and by references from review articles...
December 24, 2016: Veterinary Record
https://www.readbyqxmd.com/read/27185954/variants-within-the-sp110-nuclear-body-protein-modify-risk-of-canine-degenerative-myelopathy
#10
Emma L Ivansson, Kate Megquier, Sergey V Kozyrev, Eva Murén, Izabella Baranowska Körberg, Ross Swofford, Michele Koltookian, Noriko Tonomura, Rong Zeng, Ana L Kolicheski, Liz Hansen, Martin L Katz, Gayle C Johnson, Gary S Johnson, Joan R Coates, Kerstin Lindblad-Toh
Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS). Most dogs that develop DM are homozygous for a common superoxide dismutase 1 gene (SOD1) mutation. However, not all dogs homozygous for this mutation develop disease. We performed a genome-wide association analysis in the Pembroke Welsh Corgi (PWC) breed comparing DM-affected and -unaffected dogs homozygous for the SOD1 mutation. The analysis revealed a modifier locus on canine chromosome 25...
May 31, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27109068/changes-in-respiratory-function-in-pembroke-welsh-corgi-dogs-with-degenerative-myelopathy
#11
Kanae Oyake, Yui Kobatake, Sanae Shibata, Hiroki Sakai, Miyoko Saito, Osamu Yamato, Kazuya Kushida, Sadatoshi Maeda, Hiroaki Kamishina
Canine degenerative myelopathy (DM) is characterized by progressive degeneration of the spinal cord. Although atrophic changes in the intercostal muscles were previously reported in the late stage of DM in Pembroke Welsh Corgis (PWCs), changes in respiratory function have not yet been examined. In the present study, we performed an arterial blood gas analysis and measured respiratory movements over progressive disease stages to document changes in respiratory function in DM-affected PWCs. We found that respiratory dysfunction progressed during the later stages of DM and correlated with a change in respiratory movement to the abdominal breathing pattern...
September 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/26693480/effects-of-bee-venom-injections-at-acupoints-on-neurologic-dysfunction-induced-by-thoracolumbar-intervertebral-disc-disorders-in-canines-a-randomized-controlled-prospective-study
#12
RANDOMIZED CONTROLLED TRIAL
Li-Chuan Tsai, Yi-Wen Lin, Ching-Liang Hsieh
Intervertebral disk disease (IVDD) is a major spine disorder in canines that causes neurological dysfunction, particularly in the thoracolumbar area. Analgesic and anti-inflammatory drugs are typically used to reduce nociceptive signals to decrease canine suffering. Bee venom (BV) has been reported to exert anti-inflammatory and analgesic effects. Injection of BV at acupoints has been widely used to treat clinical disorders including inflammation, pain, and arthritis. The current study was intended to determine whether BV injections at acupoints can enhance treatment of canine neurological dysfunction caused by IVDD...
2015: BioMed Research International
https://www.readbyqxmd.com/read/26592800/imaging-diagnosis-vertebral-polyostotic-lymphoma-in-a-geriatric-dog
#13
Julie Kornder, Simon R Platt, Joe Eagleson, Marc Kent, Shannon P Holmes
A 9-year-old spayed female Scottish terrier presented with an 8-day history of progressive paraparesis. Neurological examination suggested a painful T3-L3 myelopathy. Multifocal uniform contrast-enhancing masses involving the vertebral bodies, pedicles, laminae, and spinous processes of two vertebrae and compressing the spinal cord were present on MRI. Fluoroscopic-guided fine needle aspiration of one of the vertebral lesions revealed a predominantly lymphoblastic population of cells compatible with a diagnosis of lymphoma...
July 2016: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/26432396/canine-degenerative-myelopathy-a-model-of-human-amyotrophic-lateral-sclerosis
#14
REVIEW
Raffaele Nardone, Yvonne Höller, Alexandra C Taylor, Piergiorgio Lochner, Frediano Tezzon, Stefan Golaszewski, Francesco Brigo, Eugen Trinka
Canine degenerative myelopathy (CDM) represents a unique naturally occurring animal model for human amyotrophic lateral sclerosis (ALS) because of similar clinical signs, neuropathologic findings, and involvement of the superoxide dismutase 1 (SOD1) mutation. A definitive diagnosis can only be made postmortem through microscopic detection of axonal degeneration, demyelination and astroglial proliferation, which is more severe in the dorsal columns of the thoracic spinal cord and in the dorsal portion of the lateral funiculus...
February 2016: Zoology: Analysis of Complex Systems, ZACS
https://www.readbyqxmd.com/read/26403185/a-preliminary-evaluation-of-the-reliability-of-a-modified-functional-scoring-system-for-assessing-neurologic-function-in-ambulatory-thoracolumbar-myelopathy-dogs
#15
Chung-Sheng Lee, R Timothy Bentley, Hsin-Yi Weng, Gert J Breur
BACKGROUND: The objective of this study was to develop and assess the reliability of a modified scoring system for evaluating the function of the two pelvic limbs separately, in ambulatory thoracolumbar myelopathy dogs. A previously established neurologic score scale for dogs with T3-L3 lesions was modified in order to provide a separate score for each pelvic limb. RESULTS: Seventeen ambulatory dogs with thoracolumbar myelopathies were evaluated. Using the new scale, two observers independently performed 22 observational gait analyses (OGAs) in ten dogs without videotape...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26401327/a-retrospective-study-of-the-prevalence-of-the-canine-degenerative-myelopathy-associated-superoxide-dismutase-1-mutation-sod1-c-118g%C3%A2-%C3%A2-a-in-a-referral-population-of-german-shepherd-dogs-from-the-uk
#16
Angela L Holder, James A Price, Jamie P Adams, Holger A Volk, Brian Catchpole
BACKGROUND: Canine degenerative myelopathy (CDM) is an adult onset, progressive neurodegenerative disease of the spinal cord. The disease was originally described in the German Shepherd dog (GSD), but it is now known to occur in many other dog breeds. A previous study has identified a mutation in the superoxide dismutase 1 gene (SOD1:c.118G > A) that is associated with susceptibility to CDM. In the present study, restriction fragment length polymorphism (RFLP) analysis was used to genotype GSD for SOD1:c...
2014: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/26198211/clinical-reasoning-in-canine-spinal-disease-what-combination-of-clinical-information-is-useful
#17
T J A Cardy, S De Decker, P J Kenny, H A Volk
Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the patient signalment, history and neurological examination that could suggest the most likely diagnoses with statistical significance. A retrospective study of 500 dogs referred to the Queen Mother Hospital for Animals before June 2012 for the investigation of spinal disease was performed...
August 15, 2015: Veterinary Record
https://www.readbyqxmd.com/read/26162235/accumulation-and-aggregate-formation-of-mutant-superoxide-dismutase-1-in-canine-degenerative-myelopathy
#18
S Nakamae, Y Kobatake, R Suzuki, T Tsukui, S Kato, O Yamato, H Sakai, M Urushitani, S Maeda, H Kamishina
Canine degenerative myelopathy (DM) is an adult-onset progressive neurodegenerative disorder that has recently been linked to mutations in the superoxide dismutase 1 (SOD1) gene. We generated a polyclonal antibody against canine SOD1 to further characterize the mutant SOD1 protein and its involvement in DM pathogenesis. This antibody (SYN3554) was highly specific to canine SOD1 and had the ability to reveal distinct cytoplasmic aggregates in cultured cells expressing canine mutant SOD1 and also in the spinal neurons of symptomatic homozygotes...
September 10, 2015: Neuroscience
https://www.readbyqxmd.com/read/26030213/proteomic-analysis-of-cerebrospinal-fluid-in-canine-cervical-spondylomyelopathy
#19
Paula Martin-Vaquero, Ronaldo C da Costa, Matthew J Allen, Sarah A Moore, Jeremy K Keirsey, Kari B Green
STUDY DESIGN: Prospective study. OBJECTIVE: To identify proteins with differential expression in the cerebrospinal fluid (CSF) from 15 clinically normal (control) dogs and 15 dogs with cervical spondylomyelopathy (CSM). SUMMARY OF BACKGROUND DATA: Canine CSM is a spontaneous, chronic, compressive cervical myelopathy similar to human cervical spondylotic myelopathy. There is a limited knowledge of the molecular mechanisms underlying these conditions...
May 1, 2015: Spine
https://www.readbyqxmd.com/read/25732177/expression-of-autophagy-related-proteins-in-the-spinal-cord-of-pembroke-welsh-corgi-dogs-with-canine-degenerative-myelopathy
#20
M Ogawa, K Uchida, O Yamato, K Mizukami, J K Chambers, H Nakayama
Canine degenerative myelopathy (DM) is a progressive neurodegenerative disease frequently found in Pembroke Welsh Corgi (PWC) dogs, and it has clinical and pathologic similarities to human amyotrophic lateral sclerosis. Autophagy is a major intracellular protein degradation system. Abnormalities of autophagy--resulting in cell death through mechanisms called type II programmed cell death--have recently been reported to occur in various neurodegenerative diseases, including amyotrophic lateral sclerosis. Thus, the distribution and expression levels of proteins involved in autophagy were examined in the spinal cords of 8 PWC dogs suffering from DM with superoxide dismutase mutation, 5 non-DM PWC dogs, and 6 Beagle dogs without neurologic signs...
November 2015: Veterinary Pathology
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