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diabetes and tendinopathy

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https://www.readbyqxmd.com/read/28883422/effect-of-metabolic-syndrome-on-the-functional-outcome-of-corticosteroid-injection-for-lateral-epicondylitis-retrospective-matched-case-control-study
#1
Young Hak Roh, Minjoon Oh, Jung Ho Noh, Hyun Sik Gong, Goo Hyun Baek
Both obesity and diabetes mellitus are well-known risk factors for tendinopathies. We retrospectively compared the efficacy of single corticosteroid injections in treating lateral epicondylitis in patients with and without metabolic syndrome (MetS). Fifty-one patients with lateral epicondylitis and MetS were age- and sex-matched with 51 controls without MetS. Pain severity, Disability of the Arm, Shoulder, and Hand score, and grip strength were assessed at base line and at 6, 12 and 24 weeks post-injection...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811061/surgical-demographics-of-carpal-tunnel-syndrome-and-cubital-tunnel-syndrome-over-5-years-at-a-single-institution
#2
Dafang Zhang, Jamie E Collins, Brandon E Earp, Philip Blazar
PURPOSE: Carpal tunnel and cubital tunnel syndrome are the 2 most common upper-limb compressive neuropathies. However, whether the characteristics of patient populations undergoing surgery for these conditions are similar is unclear in terms of demographics and concomitant pathologies. Our null hypothesis was that there are no identifiable differences between these patient populations. METHODS: A retrospective cohort study was performed by billing system query using Common Procedural Terminology (CPT) codes for all patients who underwent open carpal tunnel release (CTR) (CPT code 64721) and/or open cubital tunnel surgery (CPT code 64718) by 1 of 4 hand surgeons from August 2008 to July 2013...
August 12, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28407683/the-effects-of-high-glucose-on-tendon-derived-stem-cells-implications-of-the-pathogenesis-of-diabetic-tendon-disorders
#3
Yu-Cheng Lin, Ying-Juan Li, Yun-Feng Rui, Guang-Chun Dai, Liu Shi, Hong-Liang Xu, Ming Ni, Song Zhao, Hui Chen, Chen Wang, Gang Li, Gao-Jun Teng
Patients with diabetes are at great risk to suffer many musculoskeletal disorders, such as tendinopathy, tendon rupture and impaired tendon healing. However, the pathogenesis of these tendon disorders still remains unclear. In this study, we aimed to investigate the effects of high glucose on cell proliferation, cell apoptosis and tendon-related markers expression of tendon-derived stem cells (TDSCs) in vitro. These findings might provide new insights into the pathogenesis of diabetic tendon disorders. The cell proliferative ability and apoptosis rate of TDSCs in different groups were evaluated by MTT assay and Annexin V-FITC/PI staining assay...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396584/a-high-glucose-diet-affects-achilles-tendon-healing-in-rats
#4
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still largely unexplored, several studies suggest a positive effect of nutritional interventions on tendon health and repair. With this study, we aim to reveal effects of a high-glucose diet on tendon neoformation in a non-diabetic rat model of Achilles tenotomy. After surgery animals received either a high-glucose diet or a control diet for 2 and 4 weeks, respectively...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266660/high-glucose-alters-tendon-homeostasis-through-downregulation-of-the-ampk-egr1-pathway
#5
Yu-Fu Wu, Hsing-Kuo Wang, Hong-Wei Chang, Jingyu Sun, Jui-Sheng Sun, Yuan-Hung Chao
Diabetes mellitus (DM) is associated with higher risk of tendinopathy, which reduces tolerance to exercise and functional activities and affects lifestyle and glycemic control. Expression of tendon-related genes and matrix metabolism in tenocytes are essential for maintaining physiological functions of tendon. However, the molecular mechanisms involved in diabetic tendinopathy remain unclear. We hypothesized that high glucose (HG) alters the characteristics of tenocyte. Using in vitro 2-week culture of tenocytes, we found that expression of tendon-related genes, including Egr1, Mkx, TGF-β1, Col1a2, and Bgn, was significantly decreased in HG culture and that higher glucose consumption occurred...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229814/could-leptin-deficient-mice-be-good-novel-models-for-diabetic-achilles-tendinopathy
#6
Min-Jun Huang, Can-Jun Zeng, Liang Wang
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May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28229813/reply-to-could-leptin-deficient-mice-be-good-novel-models-for-diabetic-achilles-tendinopathy
#7
Jinfei Ji, Qing Jiang
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May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28185130/frequency-of-shoulder-corticosteroid-injections-for-pain-and-stiffness-after-shoulder-surgery-and-their-potential-to-enhance-outcomes-with-physiotherapy-a-retrospective-study
#8
John G Skedros, Micheal G Adondakis, Alex N Knight, Michael B Pilkington
INTRODUCTION: What is the rate of injecting patients with shoulder corticosteroid injections to alleviate excessive stiffness and pain within 6 months after shoulder surgery? METHODS: Retrospective 10-year review of a shoulder surgeon's practice. Participants included 754 patients who had 945 non-arthroplasty shoulder surgeries. Outcome measures included the rate of injections, diagnoses, patient characteristics, and efficacy via questionnaire. RESULTS: Approximately one in five patients received a subacromial and/or glenohumeral corticosteroid injection...
June 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28106286/tendinopathy-in-diabetes-mellitus-patients-epidemiology-pathogenesis-and-management
#9
REVIEW
Pauline Po Yee Lui
Chronic tendinopathy is a frequent and disabling musculo-skeletal problem affecting the athletic and general populations. The affected tendon is presented with local tenderness, swelling, and pain which restrict the activity of the individual. Tendon degeneration reduces the mechanical strength and predisposes it to rupture. The pathogenic mechanisms of chronic tendinopathy are not fully understood and several major non-mutually exclusive hypotheses including activation of the hypoxia-apoptosis-pro-inflammatory cytokines cascade, neurovascular ingrowth, increased production of neuromediators, and erroneous stem cell differentiation have been proposed...
January 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28095484/experimental-diabetes-alters-the-morphology-and-nano-structure-of-the-achilles-tendon
#10
Rodrigo Ribeiro de Oliveira, Rômulo Medina de Mattos, Luciana Magalhães Rebelo, Fernanda Guimarães Meireles Ferreira, Fernanda Tovar-Moll, Luiz Eurico Nasciutti, Gerly Anne de Castro Brito
Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin...
2017: PloS One
https://www.readbyqxmd.com/read/27833972/evaluation-of-normal-and-pathological-achilles-tendon-by-real-time-shear-wave-elastography
#11
Pompiliu HoraŢiu Petrescu, Dragoş Andrei Izvernariu, Cătălina Iancu, Gabriel Ovidiu Dinu, Dan Crişan, Simona Alina Popescu, Roxana Lucia Denisa Şirli, Bogdan Mihai Nistor, Ion Călin RăuŢia, Dorela CodruŢa Lăzureanu, Sorin Dema, Ion Radu Prejbeanu, Ioan Sporea
Tendinopathy covers a range of several tendon conditions, mostly caused by overuse but at least in Achilles tendon pathology, favored by obesity, diabetes, inflammatory and autoimmune conditions. Subclinical tendon pathology is difficult to diagnose, as magnetic resonance imaging (MRI) examinations are sometimes inconclusive and not cost-effective. Elastography is an ultrasound examination method that uses mechanical impulses to produce shear waves in the tissue of interest, then measures the tissue displacement and calculates the shear wave speed or the elastic modulus of the examined tissue...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27535271/general-overview-and-summary-of-concepts-regarding-tendon-disease-topics-addressed-related-to-metabolic-disorders
#12
Paul W Ackermann, David A Hart
Painful and non-healing musculoskeletal disorders, eg. tendinopathy, pose a tremendous burden on society and the quality of life for patients. New advances in the understanding of connective tissue disorders such as tendinopathy reveal that common health problems such as obesity, atherosclerosis, hormonal dysfunctions and diabetes mellitus are closely linked to the metabolism of components of the musculoskeletal system, particularly tendons. As tendons function as multi-component "organ systems" (Muscle-TMJ-Tendon-Enthesis to Bone), tendons can be influenced directly, or indirectly via, for instance, alterations to muscle...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535262/rehabilitation-of-tendon-problems-in-patients-with-diabetes-mellitus
#13
Jonathan Rees, Jamie E Gaida, Karin Grävare Silbernagel, Johannes Zwerver, Joseph S Anthony, Alex Scott
Exercise is crucial in the management of diabetes mellitus and its associated complications. However, individuals with diabetes have a heightened risk of musculoskeletal problems, including tendon pathologies. Diabetes has a significant impact on the function of tendons due to the accumulation of advanced glycation end-products in the load-bearing collagen. In addition, tendon vascularity and healing may be reduced due to diabetes-induced changes in the peripheral vascular system, and impaired synthesis of collagen and glycosaminoglycan...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535259/does-diabetes-mellitus-affect-tendon-healing
#14
Aisha Siddiqah Ahmed
Diabetes mellitus (DM) is a metabolic disorder resulting from defective insulin production and characterized by chronic hyperglycemia. DM affects around 170 million people worldwide and its incidence is increasing globally. DM can cause a wide range of musculoskeletal disorders such as painful tendinopathies, tendon contracture, tendon rupture, and rotator cuff tear.In patients with diabetes neuropathy, diminished peripheral blood flow and decreased local angiogenesis are reported which probably are results of abnormalities in the production of collagen production, inflammatory mediators, angiogenic and growth factors and also contribute to lack of healing in damaged tissue...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535247/tendon-innervation
#15
Paul W Ackermann, Paul Salo, David A Hart
The regulation of tendon metabolism including the responses to loading is far from being well understood. During the last decade, however, accumulating data show that tendon innervation in addition to afferent functions, via efferent pathways has a regulatory role in tendon homeostasis via a wide range of neuromediators, which coordinate metabolic and neuro-inflammatory pathways.Innervation of intact healthy tendons is localized in the surrounding structures, i.e paratenon, endotenon and epitenon, whereas the tendon proper is practically devoid of neuronal supply...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26598716/is-there-an-association-between-tendinopathy-and-diabetes-mellitus-a-systematic-review-with-meta-analysis
#16
REVIEW
Tom A Ranger, Andrea M Y Wong, Jill L Cook, Jamie E Gaida
BACKGROUND: Musculoskeletal symptoms limit adherence to exercise interventions for individuals with type 2 diabetes. People with diabetes may be susceptible to tendinopathy due to chronically elevated blood glucose levels. Therefore, we aimed to investigate this potential association by systematically reviewing and meta-analysing case-control, cross-sectional, and studies that considered both of these conditions. METHODS: Nine medical databases and hand searching methods were used without year limits to identify all relevant English language articles that considered diabetes and tendinopathy...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26397266/elevated-hemoglobin-a1c-levels-correlate-with-blood-glucose-elevation-in-diabetic-patients-following-local-corticosteroid-injection-in-the-hand-a-prospective-study
#17
Nayoung Kim, Jake Schroeder, C Edward Hoffler, Jonas L Matzon, Kevin F Lutsky, Pedro K Beredjiklian
BACKGROUND: Diabetic patients develop hand conditions that are managed with local corticosteroid injections. Injections can result in a transient elevation in serum glucose in diabetic patients. Hemoglobin A1c is the accepted measure of long-term plasma glucose control in diabetics (levels ≥7 percent reflect poor blood glucose control). The purpose of this study was to assess the relationship between hemoglobin A1c levels and increased blood glucose levels after corticosteroid injections...
October 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26310937/influence-of-acute-and-chronic-streptozotocin-induced-diabetes-on-the-rat-tendon-extracellular-matrix-and-mechanical-properties
#18
Brent D Volper, Richard T Huynh, Kathryn A Arthur, Joshua Noone, Benjamin D Gordon, Emily W Zacherle, Eduardo Munoz, Mikkel A Sørensen, René B Svensson, Tom L Broderick, S Peter Magnusson, Reuben Howden, Taben M Hale, Chad C Carroll
Diabetes is a major risk factor for tendinopathy, and tendon abnormalities are common in diabetic patients. The purpose of the present study was to evaluate the effect of streptozotocin (60 mg/kg)-induced diabetes and insulin therapy on tendon mechanical and cellular properties. Sprague-Dawley rats (n = 40) were divided into the following four groups: nondiabetic (control), 1 wk of diabetes (acute), 10 wk of diabetes (chronic), and 10 wk of diabetes with insulin treatment (insulin). After 10 wk, Achilles tendon and tail fascicle mechanical properties were similar between groups (P > 0...
November 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26199034/-dwyer-osteotomy-lateral-sliding-osteotomy-of-calcaneus
#19
A Barg, H Hörterer, M Jacxsens, M Wiewiorski, J Paul, V Valderrabano
OBJECTIVE: To correct the underlying inframalleolar varus deformity and to restore physiologic biomechanics of the hindfoot. INDICATIONS: Neurologic, posttraumatic, congenital, and idiopathic cavovarus deformity. In patients with end-stage ankle osteoarthritis with varus heel malposition as additional single-stage procedure complementing total ankle replacement. Severe peroneal tendinopathy with concomitant cavovarus deformity. CONTRAINDICATIONS: General surgical or anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy (e...
August 2015: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/26059613/achilles-tendinopathy-in-elderly-subjects-with-type-ii-diabetes-the-role-of-sport-activities
#20
Michele Abate, Vincenzo Salini, Cosima Schiavone
BACKGROUND: Exercise is an important therapeutic tool in the management of diabetes in older people. Aim of this study was to assess the relationship among type II diabetes, sport, overweight, and symptomatic Achilles tendinopathy in elderly subjects. METHODS: Thirty-eight patients suffering from Achilles tendinopathy and thirty-eight controls were enrolled. The prevalence of diabetes and sport practice as well as BMI and Glycated Hemoglobin (HbA1c) values were registered...
April 2016: Aging Clinical and Experimental Research
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