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diabetes and tendinopathy

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https://www.readbyqxmd.com/read/28266660/high-glucose-alters-tendon-homeostasis-through-downregulation-of-the-ampk-egr1-pathway
#1
Yu-Fu Wu, Hsing-Kuo Wang, Hong-Wei Chang, Jingyu Sun, Jui-Sheng Sun, Yuan-Hung Chao
Diabetes mellitus (DM) is associated with higher risk of tendinopathy, which reduces tolerance to exercise and functional activities and affects lifestyle and glycemic control. Expression of tendon-related genes and matrix metabolism in tenocytes are essential for maintaining physiological functions of tendon. However, the molecular mechanisms involved in diabetic tendinopathy remain unclear. We hypothesized that high glucose (HG) alters the characteristics of tenocyte. Using in vitro 2-week culture of tenocytes, we found that expression of tendon-related genes, including Egr1, Mkx, TGF-β1, Col1a2, and Bgn, was significantly decreased in HG culture and that higher glucose consumption occurred...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229814/could-leptin-deficient-mice-be-good-novel-models-for-diabetic-achilles-tendinopathy
#2
Min-Jun Huang, Can-Jun Zeng, Liang Wang
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February 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28229813/reply-to-could-leptin-deficient-mice-be-good-novel-models-for-diabetic-achilles-tendinopathy-by-m-j-huang-et-al
#3
Jinfei Ji, Qing Jiang
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February 10, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28185130/frequency-of-shoulder-corticosteroid-injections-for-pain-and-stiffness-after-shoulder-surgery-and-their-potential-to-enhance-outcomes-with-physiotherapy-a-retrospective-study
#4
John G Skedros, Micheal G Adondakis, Alex N Knight, Michael B Pilkington
INTRODUCTION: What is the rate of injecting patients with shoulder corticosteroid injections to alleviate excessive stiffness and pain within 6 months after shoulder surgery? METHODS: Retrospective 10-year review of a shoulder surgeon's practice. Participants included 754 patients who had 945 non-arthroplasty shoulder surgeries. Outcome measures included the rate of injections, diagnoses, patient characteristics, and efficacy via questionnaire. RESULTS: Approximately one in five patients received a subacromial and/or glenohumeral corticosteroid injection...
February 9, 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28106286/tendinopathy-in-diabetes-mellitus-patients-epidemiology-pathogenesis-and-management
#5
REVIEW
Pauline Po Yee Lui
Chronic tendinopathy is a frequent and disabling musculo-skeletal problem affecting the athletic and general populations. The affected tendon is presented with local tenderness, swelling, and pain which restrict the activity of the individual. Tendon degeneration reduces the mechanical strength and predisposes it to rupture. The pathogenic mechanisms of chronic tendinopathy are not fully understood and several major non-mutually exclusive hypotheses including activation of the hypoxia-apoptosis-pro-inflammatory cytokines cascade, neurovascular ingrowth, increased production of neuromediators, and erroneous stem cell differentiation have been proposed...
January 20, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28095484/experimental-diabetes-alters-the-morphology-and-nano-structure-of-the-achilles-tendon
#6
Rodrigo Ribeiro de Oliveira, Rômulo Medina de Mattos, Luciana Magalhães Rebelo, Fernanda Guimarães Meireles Ferreira, Fernanda Tovar-Moll, Luiz Eurico Nasciutti, Gerly Anne de Castro Brito
Although of several studies that associate chronic hyperglycemia with tendinopathy, the connection between morphometric changes as witnessed by magnetic resonance (MR) images, nanostructural changes, and inflammatory markers have not yet been fully established. Therefore, the present study has as a hypothesis that the Achilles tendons of rats with diabetes mellitus (DM) exhibit structural changes. The animals were randomly divided into two experimental groups: Control Group (n = 06) injected with a vehicle (sodium citrate buffer solution) and Diabetic Group (n = 06) consisting of rats submitted to intraperitoneal administration of streptozotocin...
2017: PloS One
https://www.readbyqxmd.com/read/27833972/evaluation-of-normal-and-pathological-achilles-tendon-by-real-time-shear-wave-elastography
#7
Pompiliu HoraŢiu Petrescu, Dragoş Andrei Izvernariu, Cătălina Iancu, Gabriel Ovidiu Dinu, Dan Crişan, Simona Alina Popescu, Roxana Lucia Denisa Şirli, Bogdan Mihai Nistor, Ion Călin RăuŢia, Dorela CodruŢa Lăzureanu, Sorin Dema, Ion Radu Prejbeanu, Ioan Sporea
Tendinopathy covers a range of several tendon conditions, mostly caused by overuse but at least in Achilles tendon pathology, favored by obesity, diabetes, inflammatory and autoimmune conditions. Subclinical tendon pathology is difficult to diagnose, as magnetic resonance imaging (MRI) examinations are sometimes inconclusive and not cost-effective. Elastography is an ultrasound examination method that uses mechanical impulses to produce shear waves in the tissue of interest, then measures the tissue displacement and calculates the shear wave speed or the elastic modulus of the examined tissue...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27535271/general-overview-and-summary-of-concepts-regarding-tendon-disease-topics-addressed-related-to-metabolic-disorders
#8
Paul W Ackermann, David A Hart
Painful and non-healing musculoskeletal disorders, eg. tendinopathy, pose a tremendous burden on society and the quality of life for patients. New advances in the understanding of connective tissue disorders such as tendinopathy reveal that common health problems such as obesity, atherosclerosis, hormonal dysfunctions and diabetes mellitus are closely linked to the metabolism of components of the musculoskeletal system, particularly tendons. As tendons function as multi-component "organ systems" (Muscle-TMJ-Tendon-Enthesis to Bone), tendons can be influenced directly, or indirectly via, for instance, alterations to muscle...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535262/rehabilitation-of-tendon-problems-in-patients-with-diabetes-mellitus
#9
Jonathan Rees, Jamie E Gaida, Karin Grävare Silbernagel, Johannes Zwerver, Joseph S Anthony, Alex Scott
Exercise is crucial in the management of diabetes mellitus and its associated complications. However, individuals with diabetes have a heightened risk of musculoskeletal problems, including tendon pathologies. Diabetes has a significant impact on the function of tendons due to the accumulation of advanced glycation end-products in the load-bearing collagen. In addition, tendon vascularity and healing may be reduced due to diabetes-induced changes in the peripheral vascular system, and impaired synthesis of collagen and glycosaminoglycan...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535259/does-diabetes-mellitus-affect-tendon-healing
#10
Aisha Siddiqah Ahmed
Diabetes mellitus (DM) is a metabolic disorder resulting from defective insulin production and characterized by chronic hyperglycemia. DM affects around 170 million people worldwide and its incidence is increasing globally. DM can cause a wide range of musculoskeletal disorders such as painful tendinopathies, tendon contracture, tendon rupture, and rotator cuff tear.In patients with diabetes neuropathy, diminished peripheral blood flow and decreased local angiogenesis are reported which probably are results of abnormalities in the production of collagen production, inflammatory mediators, angiogenic and growth factors and also contribute to lack of healing in damaged tissue...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27535247/tendon-innervation
#11
Paul W Ackermann, Paul Salo, David A Hart
The regulation of tendon metabolism including the responses to loading is far from being well understood. During the last decade, however, accumulating data show that tendon innervation in addition to afferent functions, via efferent pathways has a regulatory role in tendon homeostasis via a wide range of neuromediators, which coordinate metabolic and neuro-inflammatory pathways.Innervation of intact healthy tendons is localized in the surrounding structures, i.e paratenon, endotenon and epitenon, whereas the tendon proper is practically devoid of neuronal supply...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/26598716/is-there-an-association-between-tendinopathy-and-diabetes-mellitus-a-systematic-review-with-meta-analysis
#12
REVIEW
Tom A Ranger, Andrea M Y Wong, Jill L Cook, Jamie E Gaida
BACKGROUND: Musculoskeletal symptoms limit adherence to exercise interventions for individuals with type 2 diabetes. People with diabetes may be susceptible to tendinopathy due to chronically elevated blood glucose levels. Therefore, we aimed to investigate this potential association by systematically reviewing and meta-analysing case-control, cross-sectional, and studies that considered both of these conditions. METHODS: Nine medical databases and hand searching methods were used without year limits to identify all relevant English language articles that considered diabetes and tendinopathy...
August 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/26397266/elevated-hemoglobin-a1c-levels-correlate-with-blood-glucose-elevation-in-diabetic-patients-following-local-corticosteroid-injection-in-the-hand-a-prospective-study
#13
Nayoung Kim, Jake Schroeder, C Edward Hoffler, Jonas L Matzon, Kevin F Lutsky, Pedro K Beredjiklian
BACKGROUND: Diabetic patients develop hand conditions that are managed with local corticosteroid injections. Injections can result in a transient elevation in serum glucose in diabetic patients. Hemoglobin A1c is the accepted measure of long-term plasma glucose control in diabetics (levels ≥7 percent reflect poor blood glucose control). The purpose of this study was to assess the relationship between hemoglobin A1c levels and increased blood glucose levels after corticosteroid injections...
October 2015: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26310937/influence-of-acute-and-chronic-streptozotocin-induced-diabetes-on-the-rat-tendon-extracellular-matrix-and-mechanical-properties
#14
Brent D Volper, Richard T Huynh, Kathryn A Arthur, Joshua Noone, Benjamin D Gordon, Emily W Zacherle, Eduardo Munoz, Mikkel A Sørensen, René B Svensson, Tom L Broderick, S Peter Magnusson, Reuben Howden, Taben M Hale, Chad C Carroll
Diabetes is a major risk factor for tendinopathy, and tendon abnormalities are common in diabetic patients. The purpose of the present study was to evaluate the effect of streptozotocin (60 mg/kg)-induced diabetes and insulin therapy on tendon mechanical and cellular properties. Sprague-Dawley rats (n = 40) were divided into the following four groups: nondiabetic (control), 1 wk of diabetes (acute), 10 wk of diabetes (chronic), and 10 wk of diabetes with insulin treatment (insulin). After 10 wk, Achilles tendon and tail fascicle mechanical properties were similar between groups (P > 0...
November 1, 2015: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/26199034/-dwyer-osteotomy-lateral-sliding-osteotomy-of-calcaneus
#15
A Barg, H Hörterer, M Jacxsens, M Wiewiorski, J Paul, V Valderrabano
OBJECTIVE: To correct the underlying inframalleolar varus deformity and to restore physiologic biomechanics of the hindfoot. INDICATIONS: Neurologic, posttraumatic, congenital, and idiopathic cavovarus deformity. In patients with end-stage ankle osteoarthritis with varus heel malposition as additional single-stage procedure complementing total ankle replacement. Severe peroneal tendinopathy with concomitant cavovarus deformity. CONTRAINDICATIONS: General surgical or anesthesiological risks, infections, critical soft tissue conditions, nonmanageable hindfoot instability, neurovascular impairment of the lower extremity, neuroarthropathy (e...
August 2015: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/26059613/achilles-tendinopathy-in-elderly-subjects-with-type-ii-diabetes-the-role-of-sport-activities
#16
Michele Abate, Vincenzo Salini, Cosima Schiavone
BACKGROUND: Exercise is an important therapeutic tool in the management of diabetes in older people. Aim of this study was to assess the relationship among type II diabetes, sport, overweight, and symptomatic Achilles tendinopathy in elderly subjects. METHODS: Thirty-eight patients suffering from Achilles tendinopathy and thirty-eight controls were enrolled. The prevalence of diabetes and sport practice as well as BMI and Glycated Hemoglobin (HbA1c) values were registered...
April 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/25995501/what-s-new-in-foot-and-ankle-surgery
#17
REVIEW
Randall C Marx, Mark S Mizel
No abstract text is available yet for this article.
May 20, 2015: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/25937405/gastrocnemius-recession-for-foot-and-ankle-conditions-in-adults-evidence-based-recommendations
#18
REVIEW
Chris C Cychosz, Phinit Phisitkul, Daniel A Belatti, Mark A Glazebrook, Christopher W DiGiovanni
BACKGROUND: Gastrocnemius recession is a surgical technique commonly performed on individuals who suffer from symptoms related to the restricted ankle dorsiflexion that results when tight superficial posterior compartment musculature causes an equinus contracture. Numerous variations for muscle-tendon unit release along the length of the calf have been described for this procedure over the past century, although all techniques share at least partial or complete release of the gastrocnemius muscle given its role as the primary plantarflexor of the ankle...
June 2015: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/25586910/achilles-tendons-in-people-with-type-2-diabetes-show-mildly-compromised-structure-an-ultrasound-tissue-characterisation-study
#19
Suzan de Jonge, Robert Rozenberg, Bruno Vieyra, Henk J Stam, Henk-Jan Aanstoot, Harrie Weinans, Hans T M van Schie, Stephan F E Praet
BACKGROUND: Musculotendinous overuse injuries are prevalent in people with type 2 diabetes. Non-enzymatic glycosylation of collagen resulting in tendon stiffening may play a role. In this case-control study we determined whether patients with diabetes had poorer ultrasonographic structure in their Achilles tendons compared to age-matched controls. METHODS: People with type 1 diabetes or type 2 diabetes, and age-matched controls, had computerised ultrasound tissue characterisation of both Achilles tendons...
August 2015: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/25220919/diabetic-hands-a-study-on-strength-and-function
#20
COMPARATIVE STUDY
Fernanda de Carvalho e Silva, Fernanda O Jakimiu, Thelma L Skare
OBJECTIVE: To study hand strength and function in type 2 DM patients. METHODS: We collected data on hand strength and function, disease duration, glycemic, creatinine and HbA1C levels, degree of pain and stiffness and physical examination in 100 DM patients comparing than with 100 hand osteoarthritis patients and 100 controls. RESULTS: DM patients had hand strength and function better than osteoarthritis patients and worse than controls. De Quervain tendonitis associated with hand strength (p=0...
July 2014: Diabetes & Metabolic Syndrome
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