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https://www.readbyqxmd.com/read/28731209/evaluating-atypical-features-of-femur-fractures-how-change-in-radiological-criteria-influenced-incidence-and-demography-of-atypical-femur-fractures-in-a-community-setting
#1
Erin S LeBlanc, A Gabriela Rosales, Dennis M Black, Harry K Genant, Richard M Dell, Darin M Friess, David L Boardman, Douglas C Bauer, Anne de Papp, Arthur C Santora, Eric S Orwoll
Identification of atypical femoral fractures (AFFs) can be challenging. To assist in the radiological assessment, an ASBMR Task Force developed a case definition for AFFs in 2010, revising it in 2013. How the revised definition performs in a community setting compared to the 2010 definition is unknown. We applied the 2013 criteria to 372 femoral fractures that occurred between January 1, 1996, and June 30, 2009, employing two independent expert physician reviewers. We used radiographs that had been categorized in a previous study on the incidence of atypical fractures using 2010 ASMBR criteria (BEAK1)...
July 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28731051/neurotropic-melanoma-an-analysis-of-the-clinicopathological-features-management-strategies-and-survival-outcomes-for-671-patients-treated-at-a-tertiary-referral-center
#2
Alexander H R Varey, Chris Goumas, Angela M Hong, Graham J Mann, Gerald B Fogarty, Jonathan R Stretch, Robyn P M Saw, Andrew J Spillane, Kerwin F Shannon, Kenneth J Lee, Michael J Quinn, John F Thompson, Richard A Scolyer
Neurotropic cutaneous melanoma is a rare melanoma subtype that invades nerves and is often associated with desmoplastic melanoma. Limited data suggest that it has a greater propensity to recur locally, but it is unknown whether its behavior differs from that of other melanoma subtypes, including desmoplastic melanoma. We investigated clinicopathological predictors of outcome in a cohort of 671 patients with neurotropic melanoma to develop evidence-based management recommendations. Patients with primary neurotropic melanoma diagnosed from 1985 to 2013 were identified from the Melanoma Institute Australia database, along with a control cohort of 718 non-neurotropic melanoma patients...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28730752/targeted-nanotherapeutics-encapsulating-liver-x-receptor-agonist-gw3965-enhance-antiatherogenic-effects-without-adverse-effects-on-hepatic-lipid-metabolism-in-ldlr-mice
#3
Mikyung Yu, Jaume Amengual, Arjun Menon, Nazila Kamaly, Felix Zhou, Xiaoding Xu, Phei Er Saw, Seung-Joo Lee, Kevin Si, Carleena Angelica Ortega, Won Il Choi, In-Hyun Lee, Yazan Bdour, Jinjun Shi, Morteza Mahmoudi, Sangyong Jon, Edward A Fisher, Omid C Farokhzad
The pharmacological manipulation of liver X receptors (LXRs) has been an attractive therapeutic strategy for atherosclerosis treatment as they control reverse cholesterol transport and inflammatory response. This study presents the development and efficacy of nanoparticles (NPs) incorporating the synthetic LXR agonist GW3965 (GW) in targeting atherosclerotic lesions. Collagen IV (Col IV) targeting ligands are employed to functionalize the NPs to improve targeting to the atherosclerotic plaque, and formulation parameters such as the length of the polyethylene glycol (PEG) coating molecules are systematically optimized...
July 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28729785/evaluation-of-dentinal-defects-during-root-canal-preparation-using-thermomechanically-processed-nickel-titanium-files
#4
Bertan Kesim, Burak Sagsen, Tugrul Aslan
OBJECTIVE: The aim of this study was to compare the incidence of root cracks after root canal instrumentation with thermomechanically processed nickel-titanium (Ni-Ti) files with different instrumentation kinematics. MATERIALS AND METHODS: A total of 150 extracted mandibular premolars with mature apices and straight root canals were divided into five groups and used in this study. In Group 1, 30 teeth were prepared using hand K-files and assigned to control group, Group 2 was instrumented using K3XF Rotary files (SybronEndo, Glendora, CA, USA) with continuous rotary motion...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28728755/-magnetic-resonance-in-traumatic-brain-injury-a-comparative-study-of-the-different-conventional-magnetic-resonance-imaging-sequences-and-their-diagnostic-value-in-diffuse-axonal-injury
#5
Marta Cicuendez, Ana Castaño-León, Ana Ramos, Amaya Hilario, Pedro A Gómez, Alfonso Lagares
OBJECTIVE: To compare the identification capability of traumatic axonal injury (TAI) by different sequences on conventional magnetic resonance (MR) studies in traumatic brain injury (TBI) patients. MATERIAL AND METHODS: We retropectevely analyzed 264 TBI patients to whom a MR had been performed in the first 60 days after trauma. All clinical variables related to prognosis were registered, as well as the data from the initial computed tomography. The MR imaging protocol consisted of a 3-plane localizer sequence T1-weighted and T2-weighted fast spin-echo, FLAIR and gradient-echo images (GRET2*)...
July 17, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28728615/success-of-tonsillectomy-for-obstructive-sleep-apnea-in-children-with-down-syndrome
#6
David G Ingram, Amanda G Ruiz, Dexiang Gao, Norman R Friedman
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS) and associated with significant morbidity. In the current study we examined polysomnographic outcomes of children with DS who underwent tonsillectomy. METHODS: A retrospective chart review of children with DS who underwent a tonsillectomy between 2009-2015 was performed. All children had either a concurrent adenoidectomy or had previously underwent an adenoidectomy. Children with preoperative and postoperative polysomnograms within 6 months of surgery were included in the analysis...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28728555/medical-homelessness-and-candidacy-women-transiting-between-prison-and-community-health-care
#7
Penelope Abbott, Parker Magin, Joyce Davison, Wendy Hu
BACKGROUND: Women in contact with the prison system have high health needs. Short periods in prison and serial incarcerations are common. Examination of their experiences of health care both in prison and in the community may assist in better supporting their wellbeing and, ultimately, decrease their risk of returning to prison. METHODS: We interviewed women in prisons in Sydney, Australia, using pre-release and post-release interviews. We undertook thematic analysis of the combined interviews, considering them as continuing narratives of their healthcare experiences...
July 20, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28727538/per-diems-in-polio-eradication-perspectives-from-community-health-workers-and-officials
#8
Svea Closser, Anat Rosenthal, Judith Justice, Kenneth Maes, Marium Sultan, Sarah Banerji, Hailom Banteyerga Amaha, Ranjani Gopinath, Patricia Omidian, Laetitia Nyirazinyoye
Nearly all global health initiatives give per diems to community health workers (CHWs) in poor countries for short-term work on disease-specific programs. We interviewed CHWs, supervisors, and high-level officials (n = 95) in 6 study sites across sub-Saharan Africa and South Asia in early 2012 about the per diems given to them by the Global Polio Eradication Initiative. These per diems for CHWs ranged from $1.50 to $2.40 per day. International officials defended per diems for CHWs with an array of arguments, primarily that they were necessary to defray the expenses that workers incurred during campaigns...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28727207/palliative-care-physicians-experiences-of-end-of-life-communication-a-focus-group-study
#9
C Udo, M Lövgren, G Lundquist, B Axelsson
The aim of this study was to explore palliative home care physicians' experiences regarding end-of-life breakpoint communication (BPC). This is a qualitative study where focus group interviews were conducted and analysed using qualitative content analysis. The results show that the participants saw themselves as being responsible for accomplishing BPC, and they were convinced that it should be regarded as a process of communication initiated at an early stage, i.e. proactively. However, BPC was often conducted as a reaction to the patient's sudden deterioration or sometimes not at all...
July 20, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28726763/cloning-and-characterization-of-thshrs-and-thscr-transcription-factors-in-taxodium-hybrid-zhongshanshan-406
#10
Zhiquan Wang, Yunlong Yin, Jianfeng Hua, Wencai Fan, Chaoguang Yu, Lei Xuan, Fangyuan Yu
Among the GRAS family of transcription factors, SHORT ROOT (SHR) and SCARECROW (SCR) are key regulators of the formation of root tissues. In this study, we isolated and characterized two genes encoding SHR proteins and one gene encoding an SCR protein: ThSHR1 (Accession Number MF045148), ThSHR2 (Accession Number MF045149) and ThSCR (Accession Number MF045152) in the adventitious roots of Taxodium hybrid 'Zhongshanshan'. Gene structure analysis indicated that ThSHR1, ThSHR2 and ThSCR are all intron free. Multiple protein sequence alignments showed that each of the corresponding proteins, ThSHR1, ThSHR2 and ThSCR, contained five well-conserved domains: leucine heptad repeat I (LHRI), the VHIID motif, leucine heptad repeat II (LHR II), the PFYRE motif, and the SAW motif...
July 20, 2017: Genes
https://www.readbyqxmd.com/read/28726236/cross-cultural-validation-of-the-patient-perception-of-integrated-care-survey
#11
Maike V Tietschert, Federica Angeli, Arno J A van Raak, Dirk Ruwaard, Sara J Singer
OBJECTIVE: To test the cross-cultural validity of the U.S. Patient Perception of Integrated Care (PPIC) Survey in a Dutch sample using a standardized procedure. DATA SOURCES: Primary data collected from patients of five primary care centers in the south of the Netherlands, through survey research from 2014 to 2015. STUDY DESIGN: Cross-sectional data collected from patients who saw multiple health care providers during 6 months preceding data collection...
July 20, 2017: Health Services Research
https://www.readbyqxmd.com/read/28725923/assessing-3d-t2-fse-sequence-for-identification-of-the-normal-appendix-working-toward-a-single-sequence-mr-appendicitis-protocol
#12
Nattinee Leelakanok, Andrew S Phelps, Matthew A Zapala, Kambrie Kato, Michael Ohliger, Yi Li, Jesse Courtier
PURPOSES: To assess the ability of a single isotropic 3D T2 FSE sequence to identify the normal appendix in children with potential implication as alternative second-line modality in pediatric appendicitis. MATERIALS AND METHODS: Retrospective review of MR abdomino-pelvis or pelvis in children from Oct 2014-Dec 2016 was done. Only exams with 3D T2 FSE sequence performed on a single scanner type were selected. Patients with history of post appendectomy, studies in which field of view did not include ileocecal valve, with technical and protocol errors, or with fat-saturated acquisition were excluded...
July 19, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28724663/pd-l1-expression-and-immune-escape-in-melanoma-resistanceto-mapk-inhibitors
#13
Hojabr Kakavand, Robert V Rawson, Gulietta M Pupo, Jean Y H Yang, Alexander M Menzies, Matteo S Carlino, Richard F Kefford, Julie R Howle, Robyn Saw, John F Thompson, James S Wilmott, Georgina V Long, Richard A Scolyer, Helen Rizos
Purpose: To examine the relationship between immune activity, PD-L1 expression and tumor cell signaling, in metastatic melanomas prior to and during treatment with targeted MAPK inhibitors. <p>Experimental design: Thirty-eight tumors from 17 patients treated with BRAF inhibitor (n=12) or combination BRAF/MEK inhibitors (n=5) with known PD-L1 expression were analyzed. RNA expression arrays were performed on all pre-treatment (PRE, n=17), early during treatment (EDT, n=8) and progression (PROG, n=13) biopsies...
July 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28723109/fast-surface-acoustic-wave-based-sensors-to-investigate-the-kinetics-of-gas-uptake-in-ultra-microporous-frameworks
#14
Benjamin Paschke, Achim Wixforth, Dmytro Denysenko, Dirk Volkmer
Observation of the kinetics and measurement of the activation energies for gas diffusion in porous materials requires very fast and sensitive sensors. In this work, thin films of metal-organic frameworks (MOFs) with different pore sizes are grown on a surface acoustic wave (SAW) substrate, resulting in very sensitive and specific sensor systems for the detection of various gases at very short time scales. Using specially designed SAW delay lines for the detection, up to 200-nm-wide cubic MOF crystals were grown directly from a solution on the sensitive sensor chip area...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722484/consumer-perceptions-of-the-safety-of-ready-to-eat-foods-in-retail-food-store-settings
#15
Katrina Levine, Mary Yavelak, John B Luchansky, Anna C S Porto-Fett, Benjamin Chapman
To better understand how consumers perceive food safety risks in retail food store settings, a survey was administered to 1,041 nationally representative participants who evaluated possible food safety risks depicted in selected photographs and self-reported their perceptions, attitudes, and behaviors. Participants were shown 12 photographs taken at retail stores portraying either commonly perceived or actual food safety contributing factors, such as cross-contamination, product and equipment temperatures, worker hygiene, and/or store sanitation practices...
July 19, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28722439/investigation-of-polymer-plasticizer-blends-as-sh-saw-sensor-coatings-for-detection-of-benzene-in-water-with-high-sensitivity-and-long-term-stability
#16
Pintu Adhikari, Laura Alderson, Florian Bender, Antonio J Ricco, Fabien Josse
We report the first-ever direct detection of benzene in water at concentrations below 100 ppb (parts per billion) using acoustic wave (specifically, shear-horizontal surface acoustic wave, SH-SAW) sensors with plasticized polymer coatings. Two polymers and two plasticizers were studied as materials for sensor coatings. For each polymer-plasticizer combination, the influence of the mixing ratio of the blend on the sensitivity to benzene was measured and compared to commercially available polymers that were used for BTEX (benzene, toluene, ethylbenzene, and xylene) detection in previous work...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28722017/the-role-of-age-related-t-cell-differentiation-in-patients-with-renal-replacement-therapy
#17
Matthias Schaier, Angele Leick, Lorenz Uhlmann, Florian Kälble, Volker Eckstein, Anthony Ho, Stefan Meuer, Karsten Mahnke, Claudia Sommerer, Martin Zeier, Andrea Steinborn
Dialysis patients have deficiencies regarding the generation of immune responses and show an increased susceptibility for infections. Persisting uremic conditions are made responsible for the increased aging of their immune system. In this study, we analyzed whether age-related differences in the differentiation of both recent-thymic-emigrant-(RTE)-regulatory (Tregs) and RTE-responder T cells (Tresps) into CD31(-)-memory Tregs/Tresps led to differences in the suppressive activity of naïve and memory Tregs on autologous Tresps between healthy volunteers and dialysis patients...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28721763/-run-hide-tell-applies-to-nurses-too
#18
Erin Dean
Nursing student Rhiannon Owen was at a cash machine in a busy area of London on a Saturday night when a taxi swerved towards her and the driver screamed at her to run. Looking up, she saw a man three metres away holding a knife with a 12-inch blade.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721395/the-online-appeal-of-the-physical-shop-how-a-physical-store-can-benefit-from-a-virtual-representation
#19
Anne Moes, Harry van Vliet
Consumer behaviour in 2016 shows that (r)etailers need online/offline integration to better serve their clients. An important distinguishing feature of the physical shop is how it can offer consumers a shopping experience. This study uses two experiments to research the extent a fashion store's shopping experience can be presented to consumers via visual material (a regular photo, a 360-degree photo and a virtual reality photo of the shop) without the consumers being in the shop itself. The effects of these visual materials will also be measured in (among others) terms of purchase intention, visiting intention to the physical shop and online visit satisfaction...
June 2017: Heliyon
https://www.readbyqxmd.com/read/28720114/effects-of-the-equip-quasi-experimental-study-testing-a-collaborative-quality-improvement-approach-for-maternal-and-newborn-health-care-in-tanzania-and-uganda
#20
P Waiswa, F Manzi, G Mbaruku, A K Rowe, M Marx, G Tomson, T Marchant, B A Willey, J Schellenberg, S Peterson, C Hanson
BACKGROUND: Quality improvement is a recommended strategy to improve implementation levels for evidence-based essential interventions, but experience of and evidence for its effects in low-resource settings are limited. We hypothesised that a systemic and collaborative quality improvement approach covering district, facility and community levels, supported by report cards generated through continuous household and health facility surveys, could improve the implementation levels and have a measurable population-level impact on coverage and quality of essential services...
July 18, 2017: Implementation Science: IS
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