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https://www.readbyqxmd.com/read/28829068/a-surface-acoustic-wave-biosensor-synergizing-dna-mediated-in-situ-silver-nanoparticle-growth-for-a-highly-specific-and-signal-amplified-nucleic-acid-assay
#1
Yulin Zhang, Fan Yang, Zhongyue Sun, Yu-Tao Li, Guo-Jun Zhang
This work reports a surface acoustic wave (SAW) DNA sensor that synergizes the surface mass effect for signal-amplified and sequence-specific DNA detection in blood serum. By combining an enzyme-mediated DNA extension reaction (both viscoelastic and mass fractions) with the in situ synthesis of silver nanoparticles (mass fraction), a highly sensitive SAW biosensing interface with synergistic mass loading was tailor-engineered. As target DNA hybridized with the surface-confined capture probes, the exposed 3'-OH terminal of the target sequence could be triggered to elongate in the presence of terminal deoxynucleoside transferase (TdT) and deoxy-ribonucleoside triphosphate (dNTP), thereby producing an evident mass effect...
August 22, 2017: Analyst
https://www.readbyqxmd.com/read/28828357/definition-and-epidemiology-of-acute-respiratory-distress-syndrome
#2
REVIEW
Emanuele Rezoagli, Roberto Fumagalli, Giacomo Bellani
Fifty years ago, Ashbaugh and colleagues defined for the first time the acute respiratory distress syndrome (ARDS), one among the most challenging clinical condition of the critical care medicine. The scientific community worked over the years to generate a unified definition of ARDS, which saw its revisited version in the Berlin definition, in 2014. Epidemiologic information about ARDS is limited in the era of the new Berlin definition, and wide differences are reported among countries all over the world. Despite decades of study in the field of lung injury, ARDS is still so far under-recognized, with 2 out of 5 cases missed by clinicians...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28827807/a-prospective-cohort-study-of-the-effectiveness-of-the-primary-hospital-management-of-all-snakebites-in-kurunegala-district-of-sri-lanka
#3
Seyed Shahmy, Senanayake A M Kularatne, Shantha S Rathnayake, Andrew H Dawson
INTRODUCTION: Sri Lanka records substantial numbers of snakebite annually. Primary rural hospitals are important contributors to health care. Health care planning requires a more detailed understanding of snakebite within this part of the health system. This study reports the management and epidemiology of all hospitalised snakebite in the Kurunegala district in Sri Lanka. METHODOLOGY: The district has 44 peripheral/primary hospitals and a tertiary care hospital-Teaching Hospital, Kurunegala (THK)...
August 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28827610/body-mass-index-trajectories-in-the-first-two-years-and-subsequent-childhood-cardio-metabolic-outcomes-a-prospective-multi-ethnic-asian-cohort-study
#4
Izzuddin M Aris, Ling-Wei Chen, Mya Thway Tint, Wei Wei Pang, Shu E Soh, Seang-Mei Saw, Lynette Pei-Chi Shek, Kok-Hian Tan, Peter D Gluckman, Yap-Seng Chong, Fabian Yap, Keith M Godfrey, Michael S Kramer, Yung Seng Lee
We investigated body mass index (BMI) trajectories in the first 2 years of life in 1170 children from an Asian mother-offspring cohort in Singapore, and examined their predictors and associations with childhood cardio-metabolic risk measures at 5 years. Latent class growth mixture modelling analyses were performed to identify distinct BMI z-score (BMIz) trajectories. Four trajectories were identified: 73.2%(n = 857) of the children showed a normal BMIz trajectory, 13.2%(n = 155) a stable low-BMIz trajectory, 8...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826809/landfill-gas-distribution-at-the-base-of-passive-methane-oxidation-biosystems-transient-state-analysis-of-several-configurations
#5
Bahar Ahoughalandari, Alexandre R Cabral
The design process of passive methane oxidation biosystems needs to include design criteria that account for the effect of unsaturated hydraulic behavior on landfill gas migration, in particular, restrictions to landfill gas flow due to the capillary barrier effect, which can greatly affect methane oxidation rates. This paper reports the results of numerical simulations performed to assess the landfill gas flow behavior of several passive methane oxidation biosystems. The concepts of these biosystems were inspired by selected configurations found in the technical literature...
August 18, 2017: Waste Management
https://www.readbyqxmd.com/read/28826648/the-synergistic-effects-of-combining-tlr-ligand-based-adjuvants-on-the-cytokine-response-are-dependent-upon-p38-jnk-signalling
#6
Lucia Fischetti, Ziyun Zhong, Christopher L Pinder, John S Tregoning, Robin J Shattock
Toll like receptor (TLR) ligands are important adjuvant candidates, causing antigen presenting cells to release inflammatory mediators, leading to the recruitment and activation of other leukocytes. The aim of this study was to define the response of human blood derived dendritic cells and macrophages to three TLR ligands acting singly or in combination, Poly I:C (TLR3), GLA (TLR4) and R848 (TLR7/8). Combinations of TLR agonists have been shown to have a synergistic effect on individual cytokines, here we look at the global inflammatory response measuring both cytokines and chemokines...
August 18, 2017: Cytokine
https://www.readbyqxmd.com/read/28822671/surgical-ultrasound-guided-carpal-tunnel-release
#7
T Apard, G Candelier
Ultrasound-guided surgery is a new trend stemming from the introduction of high-frequency linear probes and better quality screens. Surgical treatment of carpal tunnel syndrome is increasingly being performed under ultrasound guidance. Knowledge of musculoskeletal ultrasonography is obviously mandatory. Several types of cutting instruments (miniature knife, Gigli saw or hook) and surgical approaches (wrist or palm) have been described. Ultrasonography allows the wide-awake and local anesthesia with no tourniquet (WALANT) technique to be used in the context of ambulatory patient care...
August 16, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28818864/palliative-care-for-hospitalized-patients-with-stroke-results-from-the-2010-to-2012-national-inpatient-sample
#8
Tarvinder Singh, Steven R Peters, David L Tirschwell, Claire J Creutzfeldt
BACKGROUND AND PURPOSE: Substantial variability exists in the use of life-prolonging treatments for patients with stroke, especially near the end of life. This study explores patterns of palliative care utilization and death in hospitalized patients with stroke across the United States. METHODS: Using the 2010 to 2012 nationwide inpatient sample databases, we included all patients discharged with stroke identified by International Classification of Diseases-Ninth Revision codes...
August 17, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28817475/replacing-smartphones-with-mini-tablet-technology-an-evaluation
#9
Rhonda Maneval, Marci Mechtel
Handheld technology allows students to access point-of-care resources throughout the clinical experience. To assess the viability of replacing student smartphones with tablets, an evaluation project was undertaken. Overall, students were equally dissatisfied with the 2 types of tablets that were evaluated. Students saw the potential usefulness of tablets to manage clinical assignments, interact with the learning management system, and communicate with faculty, but not for retrieving information currently accessible on their phones...
August 16, 2017: Nurse Educator
https://www.readbyqxmd.com/read/28817322/diverging-life-expectancies-and-voting-patterns-in-the-2016-us-presidential-election
#10
Jacob Bor
OBJECTIVES: To assess whether voting patterns in the 2016 US presidential election were correlated with long-run trends in county life expectancy. METHODS: I examined county-level voting data from the 2008 and 2016 presidential elections and assessed Donald Trump's share of the 2016 vote, change in the Republican vote share between 2008 and 2016, and changes in absolute numbers of Democratic and Republican votes. County-level estimates of life expectancy at birth were obtained for 1980 and 2014 from the Institute for Health Metrics and Evaluation...
August 17, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28816774/practitioner-gender-and-quality-of-care-in-ambulatory-cardiology-practices-a-report-from-the-national-cardiovascular-data-practice-innovation-and-clinical-excellence-pinnacle-registry
#11
Dipti Gupta, Fengming Tang, Frederick A Masoudi, Philip G Jones, Paul S Chan, Stacie L Daugherty
BACKGROUND: Some studies suggest that female practitioners are more likely to provide guideline-concordant care than male practitioners; however, little is known about the role of practitioner gender in cardiology. OBJECTIVE: The aim of the study was to measure the association between practitioner gender and adherence to the cardiovascular performance measures in the American College of Cardiology's ambulatory Practice Innovation and Clinical Excellence Registry...
August 15, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28816467/how-sure-are-you-that-this-is-the-man-you-saw-child-witnesses-can-use-confidence-judgments-to-identify-a-target
#12
Kaila C Bruer, Ryan J Fitzgerald, Heather L Price, James D Sauer
We tested whether an alternative lineup procedure designed to minimize problematic influences (e.g., metacognitive development) on decision criteria could be effectively used by children and improve child eyewitness identification performance relative to a standard identification task. Five hundred sixteen children (6- to 13-year-olds) watched a video of a target reading word lists and, the next day, made confidence ratings for each lineup member or standard categorical decisions for 8 lineup members presented sequentially...
August 17, 2017: Law and Human Behavior
https://www.readbyqxmd.com/read/28816222/an-outlier-in-public-health-history-in-india-a-t-w-simeons-s-scheme-for-rural-medical-relief-kolhapur-1943-47
#13
Shubhada Pandya
It is customary to date provision of health services in rural India to the Report of the Bhore Committee (1946) and its descendants. It is presumed that in pre-Bhore India (the last half-century of the British era) the rural public health scenario was devoid of discerning commentators and practical effort. The presumption is misleading. Historical material shows that attempts, official and non-official, to improve rural environments and attend to the health problems of villagers were not wanting. Such efforts followed two main, sometimes intersecting, streams, namely sanitation and medical relief...
March 2017: National Medical Journal of India
https://www.readbyqxmd.com/read/28815123/rapid-and-reusable-text-visualization-and-exploration-development-with-delve
#14
Daniel R Harris, Ramakanth Kavuluru, Jerzy W Jaromczyk, Todd R Johnson
We present DELVE (Document ExpLoration and Visualization Engine), a framework for developing interactive visualizations as modular Web-applications to assist researchers with exploratory literature search. The goal for web-applications driven by DELVE is to better satisfy the information needs of researchers and to help explore and understand the state of research in scientific liter ature by providing immersive visualizations that both contain facets and are driven by facets derived from the literature. We base our framework on principles from user-centered design and human-computer interaction (HCI)...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814176/changing-beliefs-about-past-public-events-with-believable-and-unbelievable-doctored-photographs
#15
Robert A Nash
Doctored photographs can shape what people believe and remember about prominent public events, perhaps due to their apparent credibility. In three studies, subjects completed surveys about the 2012 London Olympic torch relay (Experiment 1) or the 2011 Royal Wedding of Prince William and Kate Middleton (Experiments 2-3). Some were shown a genuine photo of the event; others saw a doctored photo that depicted protesters and unrest. A third group of subjects saw a doctored photo whose inauthenticity had been made explicit, either by adding a written disclaimer (Experiment 1) or by making the digital manipulation deliberately poor (Experiments 2-3)...
August 17, 2017: Memory
https://www.readbyqxmd.com/read/28813671/oct4-and-sox2-work-as-transcriptional-activators-in-reprogramming-human-fibroblasts
#16
Santosh Narayan, Gene Bryant, Shivangi Shah, Georgina Berrozpe, Mark Ptashne
SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors. We now show that, like OCT4, SOX2 functions as a transcriptional activator. We substituted SOX2-VP16 (a strong activator) for wild-type (WT) SOX2, and we saw an increase in the efficiency and rate of reprogramming, whereas the SOX2-HP1 fusion (a strong repressor) eliminated reprogramming...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28812448/peer-network-influence-on-intimate-partner-violence-perpetration-among-urban-tanzanian-men
#17
Marta I Mulawa, Lusajo J Kajula, Suzanne Maman
Male perpetration of intimate partner violence (IPV) against women in Tanzania is widespread. Theory and empirical evidence suggest peer networks may play an important role in shaping IPV perpetration, although research on this topic in sub-Saharan Africa is limited. Grounded in social learning theory, social influence theory, and the theory of gender and power, the purpose of this study was to examine whether and how peer networks influence men's perpetration of IPV in Dar es Salaam, Tanzania. We conducted in-depth interviews (n = 40) with a sub-sample of 20 men enrolled in the control condition of an ongoing cluster-randomised controlled trial...
August 16, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28811555/identification-of-novel-micrornas-in-the-sheep-heart-and-their-regulation-in-heart-failure
#18
Lee Lee Wong, Miriam T Rademaker, Eng Leng Saw, Kar Sheng Lew, Leigh J Ellmers, Christopher J Charles, Arthur Mark Richards, Peipei Wang
Study of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810955/embedded-mental-health-promotion-of-psychological-hygiene-within-a-submarine-squadron
#19
James Rapley, John Chin, Brian McCue, Mathew Rariden
INTRODUCTION: Psychological fitness is an important component to operational unit readiness and success. Embedding behavioral health providers can reduce unplanned personnel losses (UPL) as a result of psychological stress. The U.S. Submarine Forces implemented the Submarine Squadron 6 (CSS-6) Embedded Mental Health Pilot (EMHP) Program to address this type of UPL, which is classified as a Code 2 loss. The aim of the study is to evaluate the effectiveness of the EMHP Program at reducing UPL by improving psychological readiness through expedited access to care...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810451/the-pre-history-of-health-psychology-in-the-united-kingdom-from-natural-science-and-psychoanalysis-to-social-science-social-cognition-and-beyond
#20
Michael Murray
Health psychology formally came of age in the United Kingdom in the 1980s, but it was prefigured by much discussion about challenges to the dominance of biomedicine in healthcare and debates about the role of individual behaviour change in promoting population health. Despite current progress and accomplishments, it is important to reflect upon earlier attempts to explore the psychological dimensions of health and illness. It is through such exploration that we can begin to reveal the connection between ideas and the social context...
May 1, 2017: Journal of Health Psychology
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