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https://www.readbyqxmd.com/read/28100786/inositol-depletion-induced-by-acute-treatment-of-the-bipolar-disorder-drug-valproate-increases-levels-of-phytosphingosine
#1
Shyamalagauri Jadhav, Sarah Russo, L Ashley Cowart, Miriam L Greenberg
Bipolar disorder (BD) is a severe psychiatric illness affecting ~2% of the world population. Valproate (VPA) and lithium, though widely used for the treatment of BD, are not universally effective. These drugs have been shown to cause inositol depletion, but translating this observation to a specific therapeutic mechanism has been difficult, hampering the development of more effective therapies. We have shown previously in yeast that chronic VPA treatment induces the unfolded protein response due to increasing ceramide levels...
January 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28100181/gestational-diabetes-mellitus-and-retinal-microvasculature
#2
Ling-Jun Li, Michael Kramer, Robyn J Tapp, Ryan E K Man, Ngee Lek, Shirong Cai, Fabian Yap, Peter Gluckman, Kok Hian Tan, Yap Seng Chong, Jia Yu Koh, Seang Mei Saw, Yin Bun Cheung, Tien Yin Wong
BACKGROUND: Small-vessel dysfunction may be an important consequence of chronic hyperglycemia. We examined the association between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnancy, and retinal microvascular changes in pregnant women at 26-28 weeks of pregnancy. METHODS: A total of 1136 pregnant women with singleton pregnancies were recruited during their first trimester at two major Singapore maternity hospitals in an on-going birth cohort study...
January 18, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28098545/increase-in-urgent-care-center-visits-for-sexually-transmitted-infections-united-states-2010-2014
#3
William S Pearson, Guoyu Tao, Karen Kroeger, Thomas A Peterman
During 2010-2014, urgent care centers saw a ≈2-fold increase in the number of visits for chlamydia and gonorrhea testing and a >3-fold increase in visits by persons with diagnosed sexually transmitted infections. As urgent care becomes more popular, vigilance is required to ensure proper management of these diseases.
February 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28098149/characterising-private-and-shared-signatures-of-positive-selection-in-37-asian-populations
#4
Xuanyao Liu, Dongsheng Lu, Woei-Yuh Saw, Philip J Shaw, Pongsakorn Wangkumhang, Chumpol Ngamphiw, Suthat Fucharoen, Worachart Lert-Itthiporn, Kwanrutai Chin-Inmanu, Tran Nguyen Bich Chau, Katie Anders, Anuradhani Kasturiratne, H Janaka de Silva, Tomohiro Katsuya, Ryosuke Kimura, Toru Nabika, Takayoshi Ohkubo, Yasuharu Tabara, Fumihiko Takeuchi, Ken Yamamoto, Mitsuhiro Yokota, Dolikun Mamatyusupu, Wenjun Yang, Yeun-Jun Chung, Li Jin, Boon-Peng Hoh, Ananda R Wickremasinghe, RickTwee-Hee Ong, Chiea-Chuen Khor, Sarah J Dunstan, Cameron Simmons, Sissades Tongsima, Prapat Suriyaphol, Norihiro Kato, Shuhua Xu, Yik-Ying Teo
The Asian Diversity Project (ADP) assembled 37 cosmopolitan and ethnic minority populations in Asia that have been densely genotyped across over half a million markers to study patterns of genetic diversity and positive natural selection. We performed population structure analyses of the ADP populations and divided these populations into four major groups based on their genographic information. By applying a highly sensitive algorithm haploPS to locate genomic signatures of positive selection, 140 distinct genomic regions exhibiting evidence of positive selection in at least one population were identified...
January 18, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28098000/the-crisis-we-all-saw-coming
#5
Kevin Davies
The British Red Cross is absolutely right to talk about a humanitarian crisis in the NHS (news online, 6 January; see analysis page 12 ). This strong, emotive terminology is sadly accurate.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28096304/antibiotic-cycling-and-antibiotic-mixing-which-one-best-mitigates-antibiotic-resistance
#6
R E Beardmore, R Pena-Miller, F Gori, J Iredell
Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conicting behavioural strategies that are expected to curb resistance evolution in the clinic, these are known as 'antibiotic cycling' and 'antibiotic mixing'...
January 17, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28095025/the-influence-of-personal-protection-equipment-occupant-body-size-and-restraint-system-on-the-frontal-impact-responses-of-hybrid-iii-atds-in-tactical-vehicles
#7
Lauren Wood Zaseck, Nichole Ritchie Orton, Rebekah Gruber, Jonathan Rupp, Risa Scherer, Matthew Reed, Jingwen Hu
OBJECTIVE: Although advanced restraint systems, such as seatbelt pretensioners, and load limiters, can provide improved occupant protection in crashes, such technologies are currently not utilized in military vehicles. The design and use of military vehicles presents unique challenges to occupant safety - including differences in compartment geometry and occupant clothing and gear - that make direct application of optimal civilian restraint systems to military vehicles inappropriate. For military vehicle environments, finite element (FE) modeling can be used to assess various configurations of restraint systems and determine the optimal configuration that minimizes injury risk to the occupant...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28094311/evidence-of-microvascular-changes-in-the-retina-following-kawasaki-disease
#8
Katherine Y H Chen, David P Burgner, Tien Y Wong, Seang Mei Saw, Swee Chye Quek, Audrey Y C Pang, Seo Wei Leo, Inez B Wong, Diana Zannino, Nigel Curtis, Michael Cheung, Carol Y Cheung, Terence C W Lim
It is unclear whether all children with Kawasaki disease (KD) have increased later cardiovascular risk. The retinal microvasculature reflects changes in the microcirculation and is associated with traditional cardiovascular risk factors and events. The aim of this study was to investigate retinal microvascular parameters in two populations of patients with previous KD and control participants. We performed case-control studies of 116 (57 patients and 59 control participants) Australian and 156 (78 patients and 78 control participants) Singaporean individuals, at least two years since their acute illness...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093833/cracking-the-code-residents-interpretations-of-written-assessment-comments
#9
Shiphra Ginsburg, Cees Pm van der Vleuten, Kevin W Eva, Lorelei Lingard
CONTEXT: Interest is growing in the use of qualitative data for assessment. Written comments on residents' in-training evaluation reports (ITERs) can be reliably rank-ordered by faculty attendings, who are adept at interpreting these narratives. However, if residents do not interpret assessment comments in the same way, a valuable educational opportunity may be lost. OBJECTIVES: Our purpose was to explore residents' interpretations of written assessment comments using mixed methods...
January 16, 2017: Medical Education
https://www.readbyqxmd.com/read/28088881/an-industry-update-the-latest-developments-in-therapeutic-delivery
#10
Iain Simpson
This Industry Update covers the period from 1 October through to 31 October 2016, and is based on information sourced from company press releases, scientific literature, patents and various news websites. The month saw several news items covering drug-delivery devices, including a new sensor to monitor and support the use of inhalers; launch in the UK of a new autoinjector for Cimzia(®), UCB's rheumatoid arthritis drug; and approval of Roche's Lucentis(®) in a prefilled syringe. Research was also published to show the value of continuous blood pressure monitoring in dementia management...
February 2017: Therapeutic Delivery
https://www.readbyqxmd.com/read/28088039/read-my-lips-visual-speech-influences-word-processing-in-infants
#11
Drew Weatherhead, Katherine S White
What do infants hear when they read lips? In the present study, twelve-to-thirteen-month-old infants viewed a talking face produce familiar and unfamiliar words. The familiar words were of three types: in Experiment 1, they were produced correctly (e.g., "bottle"); in Experiment 2, infants saw and heard mispronunciations in which the altered phoneme either visually resembled the original phoneme (visually consistent, e.g. "pottle"), or did not visually resemble the original phoneme (visually inconsistent, e...
January 11, 2017: Cognition
https://www.readbyqxmd.com/read/28087283/benefits-of-using-the-ultrasonic-bonescalpel%C3%A2-in-temporomandibular-joint-reconstruction
#12
Rebeka Silva, Rishi Gupta, Gianluca Tartaglia, Stephen Connelly
PURPOSE: The main objective of this retrospective study is to analyze and report on our operative experiences and outcomes using the ultrasonic BoneScalpel™ (BoneScalpel) versus a conventional reciprocating saw (RecipSaw) for the purpose of completing the osteotomies in total temporomandibular joint reconstruction (TJR) surgery. MATERIALS AND METHODS: 23 consecutive patients presented with a diagnosis of either degenerative joint disease (n = 23), a failing autogenous TJR (n = 1), heterotrophic bone formation (n = 1) or a subcondylar fracture (n = 1) for a total of 26 joints that received a TJR...
December 19, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28081136/task-irrelevant-external-cues-can-influence-language-selection-in-voluntary-object-naming-evidence-from-hindi-english-bilinguals
#13
Divya Bhatia, Seema Gorur Prasad, Kaushik Sake, Ramesh Kumar Mishra
We examined if external cues such as other agents' actions can influence the choice of language during voluntary and cued object naming in bilinguals in three experiments. Hindi-English bilinguals first saw a cartoon waving at a color patch. They were then asked to either name a picture in the language of their choice (voluntary block) or to name in the instructed language (cued block). The colors waved at by the cartoon were also the colors used as language cues (Hindi or English). We compared the influence of the cartoon's choice of color on naming when speakers had to indicate their choice explicitly before naming (Experiment 1) as opposed to when they named directly on seeing the pictures (Experiment 2 and 3)...
2017: PloS One
https://www.readbyqxmd.com/read/28080293/proximal-contact-repair-of-complex-amalgam-restorations
#14
M N Zguri, J A Casey, J P Jessup, K S Vandewalle
The carving of a complex amalgam restoration may occasionally result in light proximal contact with the adjacent tooth. The purpose of this study was to investigate the strength of complex amalgam restorations repaired with a proximal slot amalgam preparation. Extracted human third molars of similar coronal size were sectioned 1 mm apical to the height of the contour using a saw and were randomly distributed into 9 groups of 10 teeth each. One pin was placed at each line angle of the flattened dentinal tooth surface...
January 12, 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28080118/photos-that-increase-feelings-of-learning-promote-positive-evaluations
#15
Brittany A Cardwell, Eryn J Newman, Maryanne Garry, Antonia Mantonakis, Randi Beckett
Research shows that when semantic context makes it feel easier for people to bring related thoughts and images to mind, people can misinterpret that feeling of ease as evidence that information is positive. But research also shows that semantic context does more than help people bring known concepts to mind-it also teaches people new concepts. In five experiments, we show that when photos increase these feelings of learning, they also increase positive evaluations. People saw fictitious wine names and evaluated claims about each...
January 12, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28080077/dogs-canis-familiaris-attention-to-human-perception-influence-of-breed-groups-and-life-experiences
#16
Marianne T E Heberlein, Dennis C Turner, Marta B Manser
Attending to the perception of others may help individuals gaining information from conspecifics, or help in competitive situations. Dogs (Canis familiaris) are attentive to humans' signals and their attentional state. We investigated whether dogs of different breed groups differ in their ability to pay attention to human's perception, first according to the genetic relatedness between dog breeds, and second according to working style differences. Once dogs had learned to leave forbidden food on the floor, they were confronted with 2 food items to which only they had unrestricted visual access...
January 12, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28079901/the-clinical-utility-of-dna-based-screening-for-fetal-aneuploidy-by-primary-obstetrical-care-providers-in-the-general-pregnancy-population
#17
Glenn E Palomaki, Edward M Kloza, Barbara M O'Brien, Elizabeth E Eklund, Geralyn M Lambert-Messerlian
OBJECTIVE: To assess the clinical utility of cell-free DNA (cfDNA)-based screening for aneuploidies offered through primary obstetrical care providers to a general pregnancy population. METHODS: Patient educational materials were developed and validated and providers were trained. Serum was collected for reflexive testing of cfDNA failures. Providers and patients were surveyed concerning knowledge, decision making, and satisfaction. Pregnancy outcome was determined by active or passive ascertainment...
January 12, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28078771/the-see-saw-of-immune-dysregulation-association-of-diverse-organ-autoimmune-conditions-in-a-woman-evolution-over-twenty-seven-years
#18
Mauricio Goihman-Yahr
No abstract text is available yet for this article.
January 11, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28077874/asgard-archaea-illuminate-the-origin-of-eukaryotic-cellular-complexity
#19
Katarzyna Zaremba-Niedzwiedzka, Eva F Caceres, Jimmy H Saw, Disa Bäckström, Lina Juzokaite, Emmelien Vancaester, Kiley W Seitz, Karthik Anantharaman, Piotr Starnawski, Kasper U Kjeldsen, Matthew B Stott, Takuro Nunoura, Jillian F Banfield, Andreas Schramm, Brett J Baker, Anja Spang, Thijs J G Ettema
The origin and cellular complexity of eukaryotes represent a major enigma in biology. Current data support scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial) endosymbiont merged together, resulting in the first eukaryotic cell. The host cell is related to Lokiarchaeota, an archaeal phylum with many eukaryotic features. The emergence of the structural complexity that characterizes eukaryotic cells remains unclear. Here we describe the 'Asgard' superphylum, a group of uncultivated archaea that, as well as Lokiarchaeota, includes Thor-, Odin- and Heimdallarchaeota...
January 19, 2017: Nature
https://www.readbyqxmd.com/read/28077660/muscle-spindles-in-human-tibialis-anterior-encode-muscle-fascicle-length-changes
#20
James Thomas Day, Leah R Bent, Ingvars Birznieks, Vaughan G Macefield, Andrew G Cresswell
Muscle spindles provide exquisitely sensitive proprioceptive information regarding joint position and movement. Through passively driven length changes in the muscle-tendon unit (MTU), muscle spindles detect joint rotations because of their in-parallel mechanical linkage to muscle fascicles. In human microneurography studies, muscle fascicles are assumed to follow the MTU and, as such, fascicle length is not measured in such studies. However, under certain mechanical conditions compliant structures can act to decouple the fascicles, and therefore the spindles, from the MTU...
January 11, 2017: Journal of Neurophysiology
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