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JOURNAL ARTICLE
Meenal S Khan, Azam Jan, Haseeb Ahmed, Mudassar Khan, Ahmad D Khan, Rafat Shakil, Bahauddin Khan, Zarkesha Aman, Waleed S Ali, Ahmad Mahmood
Introduction Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease. Early detection and timely treatment have provided successful repair of the anomaly in the developed world. However, in the developing world, there is still a burden of uncorrected TOF patients reaching adulthood. The goal of this study is to determine whether there is any difference in postoperative complications between adult and pediatric populations following surgical correction for TOF. Methods This study involved all those patients who received primary or secondary surgical repair for TOF in our facility between January 2017 and December 2020...
July 2023: Curēus
#22
JOURNAL ARTICLE
Ayako Ishikita, Chris McIntosh, Kate Hanneman, Myunghyun M Lee, Tiffany Liang, Gauri R Karur, S Lucy Roche, Edward Hickey, Tal Geva, David J Barron, Rachel M Wald
BACKGROUND: Existing models for prediction of major adverse cardiovascular events (MACE) after repair of tetralogy of Fallot have been limited by modest predictive capacity and limited applicability to routine clinical practice. We hypothesized that an artificial intelligence model using an array of parameters would enhance 5-year MACE prediction in adults with repaired tetralogy of Fallot. METHODS: A machine learning algorithm was applied to 2 nonoverlapping, institutional databases of adults with repaired tetralogy of Fallot: (1) for model development, a prospectively constructed clinical and cardiovascular magnetic resonance registry; (2) for model validation, a retrospective database comprised of variables extracted from the electronic health record...
June 2023: Circulation. Cardiovascular Imaging
#23
JOURNAL ARTICLE
Aleksandra Wasiak, Radoslaw Jaworski, Andrzej Pastuszko, Mariusz Birbach, Michal Kozlowski, Malgorzata Mirkowicz-Malek, Joanna Friedman-Gruszczynska, Bohdan Maruszewski, Andrzej Kansy
BACKGROUND: Surgical repair of tetralogy of Fallot (ToF) depends on the anatomical variations of the heart defect. A group of patients with a hypoplastic pulmonary valve annulus required a transannular patch. This study aimed to evaluate the early and late outcomes of ToF repair with a transannular Contegra® monocuspid patch in a single center. METHODS: A retrospective review of medical records was conducted. This study included 224 children with a median age of 13 months who underwent ToF repair with a Contegra® transannular patch in over 20 years of observation...
April 25, 2023: World Journal for Pediatric & Congenital Heart Surgery
#24
REVIEW
Lisa Wise-Faberowski, Jin Long, Michael Ma, Helen R Nadel, Jennifer Shek, Jeffrey A Feinstein, Elisabeth Martin, Frank L Hanley, Doff B McElhinney
BACKGROUND: In patients with tetralogy of Fallot and major aortopulmonary collaterals (MAPCAs), pulmonary blood supply is highly variable. Our approach to this condition emphasizes complete unifocalization of the pulmonary circulation, incorporating all lung segments and addressing stenoses out to the segmental level. Post-repair, we recommend serial lung perfusion scintigraphy (LPS) to assess short-term changes in pulmonary blood flow distribution. METHODS: We reviewed post-discharge and follow-up LPS performed through three years post-repair and analyzed serial changes in perfusion, risk factors for change, and the relationship between LPS parameters and pulmonary artery reintervention...
May 2023: World Journal for Pediatric & Congenital Heart Surgery
#25
JOURNAL ARTICLE
Daniel Bowen, Martijn Kauling, Bernardo Loff Barreto, Jackie McGhie, Judith Cuypers, Tamas Szili-Torok, Jolien Roos-Hesselink, Annemien van den Bosch
BACKGROUND AND PURPOSE: Electromechanical dyssynchrony, manifested by right bundle branch block and regional wall mechanical dysfunction, contributes to inefficient RV function in repaired Tetralogy of Fallot (ToF). This study aims to evaluate the synchronicity of multiple RV walls using two-dimensional multi-plane echocardiography (2D-MPE) in order to augment current understanding of the mechanisms behind RV dyssynchrony. METHODS: Sixty-nine adult ToF patients [aged 33 (23-45) years; 61% male] and twenty-five matched healthy controls underwent deformational analysis of the RV lateral, anterior, inferior and septal walls following 2D-MPE acquisitions...
2023: Frontiers in Pediatrics
#26
JOURNAL ARTICLE
Sandra D Kikano, Angela Weingarten, Sudeep D Sunthankar, William McEachern, Kristen George-Durett, David A Parra, Jonathan H Soslow, Joshua D Chew
BACKGROUND: Patients with repaired Tetralogy of Fallot (rTOF) experience a high burden of long-term morbidity, particularly arrhythmias. Cardiovascular magnetic resonance (CMR) is routinely used to assess ventricular characteristics but the relationship between CMR diastolic function and arrhythmia has not been evaluated. We hypothesized in rTOF, left ventricular (LV) diastolic dysfunction on CMR would correlate with arrhythmias and mortality. METHODS: Adolescents and adults with rTOF who underwent CMR were compared to healthy controls (n = 58)...
March 13, 2023: Journal of Cardiovascular Magnetic Resonance
#27
JOURNAL ARTICLE
Ichiro Sakamoto, Kenichiro Yamamura, Ayako Ishikita, Kisho Ohtani, Shintaro Umemoto, Hidetaka Kaku, Yuzo Yamasaki, Kohtaro Abe, Tomomi Ide, Hiroyuki Tsutsui
Pulmonary regurgitation (PR) is a risk factor for sudden cardiac death in adult patients with repaired tetralogy of Fallot (TOF). However, transthoracic echocardiography (TTE) cannot fully visualize the pulmonary valve (PV) and PR. We investigated whether intracardiac echocardiography (ICE) could visualize the PV and PR better than TTE. Thirty adult patients with TOF (mean age 33 ± 15 years) scheduled for cardiac catheterization underwent ICE. The visualization of PV and the severity of PR were classified into three grades...
January 7, 2023: Journal of Cardiovascular Development and Disease
#28
JOURNAL ARTICLE
Naofumi F Sumitomo, Kazuki Kodo, Tadashi Inoue, Takayuki Oyanagi, Hiroyuki Yamagishi
The existence of a coronary-to-pulmonary artery fistula (CPF) in pulmonary atresia with ventricular septal defect (PAVSD) potentially affects treatment; however, its clinical features have not been comprehensively described due to the disease's rarity. We reviewed 69 cases from 42 studies to reveal the clinical overview of patients with CPF and PAVSD. Among the included patients, the male-to-female ratio was exactly 1:1, and only two patients (3%) exhibited the 22q11.2 microdeletion syndrome. Regarding anatomical features, CPFs originated from the left coronary artery in 65% of patients, and 62% had other major aortopulmonary collateral arteries...
January 3, 2023: Journal of Cardiovascular Development and Disease
#29
REVIEW
Julia Hock, Laura Willinger, Robert Dalla Pozza, Peter Ewert, Alfred Hager
BACKGROUND: Lung function and cardiac function are naturally correlated by sharing the thoracic cage and handling the whole cardiac output sequentially. However, lung function studies are rare in patients with CHD, although results worthy of investigation could be expected. This review summarises existing studies with the lung function parameters (spirometry and body plethysmography) in CHD patients during the last decade. METHODS: A systematic review was performed in the relevant database (PubMed, Cochrane, and Scopus) in studies including paediatric and adult patients with CHD where lung parameters (spirometry, body plethysmography) were investigated from January 2010 to December 2020...
February 2023: Cardiology in the Young
#30
JOURNAL ARTICLE
Mikael Laredo, Guillaume Duthoit, Frederic Sacher, Frédéric Anselme, Caroline Audinet, Francis Bessiere, Pierre Bordachar, Abdeslam Bouzeman, Serge Boveda, Sok Sithikun Bun, Morgane Chassignolle, Gael Clerici, Antoine Da Costa, Maxime de Guillebon, Pascal Defaye, Nathalie Elbaz, Romain Eschalier, Fabrice Extramiana, Laurent Fauchier, Alexis Hermida, Estelle Gandjbakhch, Rodrigue Garcia, Jean Baptiste Gourraud, Charles Guenancia, Benoit Guy-Moyat, Didier Irles, Laurence Iserin, François Jourda, Linda Koutbi, Fabien Labombarda, Magalie Ladouceur, Philippe Lagrange, Nicolas Lellouche, Jacques Mansourati, Christelle Marquié, Raphael Martins, Grégoire Massoulié, Amel Mathiron, Philippe Maury, Anne Messali, Antoine Milhem, Pierre Mondoly, Cédric Nguyen, Sandro Ninni, Jean Luc Pasquié, Bertrand Pierre, Penelope Pujadas, Jean Marc Sellal, Jean Benoit Thambo, Camille Walton, Pierre Winum, Cyril Zakine, Alexandre Zhao, Xavier Jouven, Nicolas Combes, Eloi Marijon, Victor Waldmann
BACKGROUND: In repaired Tetralogy of Fallot (TOF), little is known about characteristics of patients with rapid ventricular tachycardia (VT). Also, whether patients with a first episode of non-rapid VT may subsequently develop rapid VT or VF has not been addressed. OBJECTIVE: To compare patients with rapid VT/VF to those with non-rapid VT and to assess the evolution of VT cycle lengths (VTCL) overtime. METHODS: Data were analyzed from a nationwide registry including all TOF patients with an ICD since 2000...
October 26, 2022: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#31
Shuaipeng Zhang, Haiyuan Liu, Xiangyu Wang, Shaojun Huang, Chengxin Zhang
It has been found that postoperative progressive dilatation of aortic root is not rare for adult patients with repaired Tetralogy of Fallot (TOF), which leads to severe aortic regurgitation or even fatal dissection. Therefore, clinically, surgical treatment for both regurgitated aortic valve and dilated root is needed based on preoperative assessments and individual treatment strategies.
2022: Frontiers in Cardiovascular Medicine
#32
COMPARATIVE STUDY
Michael P DiLorenzo, Grace DeCost, Anh Duc Mai, Nkecha Hughes, Elizabeth Goldmuntz, Andrea Jones, Mark A Fogel, Laura Mercer-Rosa
BACKGROUND: Serum biomarkers of myocardial fibrosis are considered markers of adverse outcome in adults with heart disease. Associations between biomarkers and clinical parameters in tetralogy of Fallot (TOF) has been understudied. We compared serum biomarker profiles with clinical and cardiac magnetic resonance (CMR) parameters of ventricular remodeling in patients with repaired TOF. METHODS: Serum biomarkers [metalloproteinases MMP1 and MMP9, galectin-3, micro-RNA21 (miR21)), ST2, procollagen type I carboxy-terminal propeptide (PICP), and NTproBNP] were measured in TOF patients undergoing CMR...
July 1, 2022: International Journal of Cardiology
#33
JOURNAL ARTICLE
Natalie S Shwaish, Lindsey Malloy-Walton, Keith Feldman, Kelli M Teson, Jessica S Watson, Hung-Wen Yeh, David A White
Attenuated heart rate recovery (HRR) following peak exercise has been shown to be a predictor of mortality in populations of adults with Fontan palliation, coronary artery disease, heart failure, and heart transplantation. However, few have studied HRR in children and adolescents with congenital heart disease (CHD). This case-control study compared HRR patterns from exercise stress testing in children and adolescents with and without repaired acyanotic CHD (raCHD). Retrospective analysis included patients aged 10-18 years who had exercise testing between 2007 and 2017...
January 4, 2022: Pediatric Cardiology
#34
JOURNAL ARTICLE
Clara Tsui, Darryl Wan, Jasmine Grewal, Marla Kiess, Amanda Barlow, Derek Human, Santabhanu Chakrabarti
BACKGROUND: Adults with repaired Tetralogy of Fallot (rTOF) comprise one of the largest cohorts among adults with congenital heart disease (ACHD). These patients have a higher burden of atrial arrhythmias (AA), leading to increased adverse events, including stroke and transient ischemic attack (TIA). However, the data on factors associated with stroke/TIA in rTOF are limited, and classic risk factors may not apply. We studied event rates and associated factors for thromboembolism in a rTOF cohort...
December 2021: Journal of Arrhythmia
#35
JOURNAL ARTICLE
Amara Majeed, Tal Geva, Lynn A Sleeper, Julia A Graf, Minmin Lu, Sonya V Babu-Narayan, Rachel M Wald, Barbara J M Mulder, Anne Marie Valente
BACKGROUND: Risk stratification in patients with repaired tetralogy of Fallot (rTOF) have focused on poor clinical outcomes while predictors of a benign clinical course have not been characterized. OBJECTIVE: The goal of this study was to Identify cardiac magnetic resonance (CMR) markers of a good clinical course late after TOF repair. METHODS: Clinical and CMR data from the International Multicenter TOF Registry (INDICATOR) were analyzed...
March 2022: American Heart Journal
#36
JOURNAL ARTICLE
Pezad Doctor, Sanjeev Aggarwal, David K Lawrence, Pooja Gupta, Gautam K Singh, Malini Madhavan, Chenni S Sriram
OBJECTIVES: To evaluate any association between non-sustained ventricular tachycardia (NSVT) detected by intra-cardiac device and clinical outcomes in repaired adult congenital heart disease (ACHD) without tetralogy of Fallot (TOF). BACKGROUND: NSVT portends a higher risk of serious ventricular tachyarrhythmia in TOF. However its clinical significance when incidentally detected by implantable cardiac device is not well elucidated in non-TOF ACHD cohort. METHODS: We performed a single center, retrospective, longitudinal follow-up study in repaired ACHD (≥18 years) patients without TOF who hosted a pacemaker or automatic implantable cardiac defibrillator (AICD)...
March 2022: Pacing and Clinical Electrophysiology: PACE
#37
Anand K Mishra, Pratyaksha Rana, Javid Raja, Vidur Bansal, Manphool Singhal
BACKGROUND: Absent pulmonary valve (PV) is a rare and severe variant seen in only 3% to 6% of patients with tetralogy of Fallot (TOF). Fetuses with this combined condition who survive through birth typically need intervention in infancy or early childhood because of respiratory distress, heart failure, or failure to thrive. DISCUSSION: Here, we describe the case of a 37 year old gentleman who presented with a diagnosis of TOF with absent PV, hugely dilated right and left pulmonary arteries and an aneurysmal right ventricular outflow...
February 2022: Journal of Cardiac Surgery
#38
JOURNAL ARTICLE
Anil Jain, Suresh Kumar Rajan, Kartik Patel, Pankaj Garg, Vishal Agrawal, Deepti Kakkar, Trushar Gajjar, Amit Mishra, Sanjay Patel, Chirag Doshi
OBJECTIVES: Adult patients undergoing tetralogy of Fallot (TOF) repair have a higher risk of mortality compared to pediatric patients. Pulmonary regurgitation (PR) further predisposes these patients to heart failure, arrhythmias, and sudden death. Pulmonary valve replacement (PVR) may improve the symptoms in these patients but, fails to reverse the other deleterious effects. Aim of our study was to evaluate the effect of concomitant PVR with TOF repair on right ventricular (RV) parameters, cardiopulmonary exercise capacity, and bioprosthetic valve durability at mid-term...
July 2021: Annals of Pediatric Cardiology
#39
JOURNAL ARTICLE
Naoko Ichikawa, Yumi Shiina, Yasufumi Kijima, Hiroyuki Kodama, Kohei Abe, Nobuyuki Komiyama, Koichiro Niwa
BACKGROUND: Aortopathy is a well-known feature of conotruncal anomalies, but it remains unknown whether valve-sparing aortic root replacement, such as the David procedure, is feasible in young patients with severe aortic regurgitation. We assessed the aortic valve complex and aortic root morphology in patients with conotruncal anomalies using echocardiography. Furthermore, we evaluated the relevant factors associated with aortopathy in this population. METHODS: A total of 172 adult patients with conotruncal anomalies were enrolled in this study...
February 2022: Journal of Cardiology
#40
JOURNAL ARTICLE
Kwannapas Saengsin, Minmin Lu, Lynn Sleeper, Tal Geva, Ashwin Prakash
BACKGROUND: Right ventricular (RV) late gadolinium enhancement (LGE) occurs due to surgical scarring and RV remodeling, and has been shown to be associated with clinical outcomes in Tetralogy of Fallot (TOF). However, it is not known if cardiovascular magnetic resonance (CMR) LGE extent progresses over time, and therefore, it is not known if serial reassessment of LGE is necessary. We determined the rate of progression in the extent of RV LGE on serial CMR examinations in repaired TOF...
June 21, 2021: Journal of Cardiovascular Magnetic Resonance
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