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Secondary hyperparathyroidism

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https://www.readbyqxmd.com/read/28328802/curative-effect-of-neutral-macroporous-resin-hemoperfusion-on-treating-hemodialysis-patients-with-refractory-uremic-pruritus
#1
Wen-Hong Li, Yu-Min Yin, Hao Chen, Xiao-Dan Wang, He Yun, Hui Li, Jie Luo, Jin-Wen Wang
This study aims to investigate the efficacy and safety of neutral macroporous resin hemoperfusion in treating maintenance hemodialysis (MHD) patients with refractory uremic pruritus (RUP).Ninety patients were enrolled and were randomly divided into 3 groups: control group, experiment 1 group, and experiment 2 group. Clinical symptom scores of skin itching were recorded before and at 4 and 8 weeks after the treatment. In addition, serum parathyroid hormone (PTH), calcium (Ca), phosphorus (P), and C-reactive protein (CRP) were detected; and the calcium-phosphorus product ([Ca] × [P]) was calculated to compare the curative effect...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28298326/let-7-and-microrna-148-regulate-parathyroid-hormone-levels-in-secondary-hyperparathyroidism
#2
Vitali Shilo, Irit Mor-Yosef Levi, Roy Abel, Aleksandra Mihailović, Gilad Wasserman, Tally Naveh-Many, Iddo Z Ben-Dov
Secondary hyperparathyroidism commonly complicates CKD and associates with morbidity and mortality. We profiled microRNA (miRNA) in parathyroid glands from experimental hyperparathyroidism models and patients receiving dialysis and studied the function of specific miRNAs. miRNA deep-sequencing showed that human and rodent parathyroids share similar profiles. Parathyroids from uremic and normal rats segregated on the basis of their miRNA expression profiles, and a similar finding was observed in humans. We identified parathyroid miRNAs that were dysregulated in experimental hyperparathyroidism, including miR-29, miR-21, miR-148, miR-30, and miR-141 (upregulated); and miR-10, miR-125, and miR-25 (downregulated)...
March 15, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28277829/etelcalcetide-for-the-treatment-of-secondary-hyperparathyroidism
#3
Naoto Hamano, Hirotaka Komaba, Masafumi Fukagawa
Calcium sensing receptor is an important target for the treatment of secondary hyperparathyroidism (SHPT). Etelcalcetide hydrochloride is a novel peptide calcimimetic agent that has a similar mechanism of action as cinacalcet hydrochloride. Clinical trials of etelcalcetide have been performed in the US, Europe, and Japan, and these trials demonstrated the safety and efficacy of etelcalcetide in dialysis patients. Etelcalcetide has recently been approved in Europe, the US and Japan. Areas covered: We review the development, pharmacokinetics, and clinical efficacy and safety of etelcalcetide for the treatment of SHPT in hemodialysis patients...
March 4, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28273687/long-term-hypovitaminosis-d-and-secondary-hyperparathyroidism-outcomes-of-the-roux-en-y-gastric-bypass-a-systematic-review
#4
REVIEW
N J Switzer, G Marcil, S Prasad, E Debru, N Church, P Mitchell, E O Billington, R S Gill
INTRODUCTION: Pre-operative Vitamin D deficiency is markedly prevalent in prospective bariatric surgery patients. While bariatric surgery leads to significant weight loss, it can exacerbate or prolong Vitamin D deficiency. We systematically reviewed the literature to assess whether secondary hyperparathyroidism is maintained in the medium to long term in patients following the Roux-en-Y gastric bypass. METHODS: A comprehensive literature search was conducted through Medline, Embase, Scopus, Web of Science, Dare, Cochrane library and HTA database...
March 8, 2017: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28272298/serum-parathyroid-hormone-responses-to-vitamin-d-supplementation-in-overweight-obese-adults-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#5
REVIEW
Ashley Lotito, Masaru Teramoto, May Cheung, Kendra Becker, Deeptha Sukumar
Obesity is often associated with vitamin D deficiency and secondary hyperparathyroidism. Vitamin D supplementation typically leads to the reductions in serum parathyroid hormone (PTH) levels, as shown in normal weight individuals. Meanwhile, the dose of vitamin D supplementation for the suppression of PTH may differ in overweight and obese adults. We conducted a systematic review and meta-analysis of randomized controlled trials to determine the dose of vitamin D supplementation required to suppress PTH levels in overweight/obese individuals...
March 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28258382/-is-autotransplantation-with-parathyroidectomy-for-secondary-hyperparathyroidism-outdated
#6
H Dralle
No abstract text is available yet for this article.
March 3, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28253186/brown-tumor-clinical-findings-of-secondary-hyperparathyroidism-in-patients-with-renal-osteodystrophy
#7
Mairaira Teles Leão E Silva, Juliana Silva Barros Cedraz, Caetano Guilherme Carvalho Pontes, Cleverson Luciano Trento, Bernardo Ferreira Brasileiro, Marta Rabello Piva, Fabiano Alvim Pereira
A brown tumor, or osteoclastoma, is a nonneoplastic bony lesion associated with hyperparathyroidism and directly related to increased levels of parathyroid hormone. These tumors result from excessive osteoclastic activity. This article presents 3 cases of brown tumor localized in facial bones. The lesions were the result of secondary hyperparathyroidism associated with chronic renal failure. The patients were two 42-year-old men and a 39-year-old woman. All patients had been treated systemically by hemodialysis for more than 10 years...
March 2017: General Dentistry
https://www.readbyqxmd.com/read/28233710/vitamin-d-deficiency-and-its-influence-on-bone-metabolism-and-density-in-a-brazilian-population-of-healthy-men
#8
Marlianne Leite Moreira, Leonardo Vieira Neto, Miguel Madeira, Renata Francioni Lopes, Maria Lucia Fleiuss Farias
Vitamin D supplementation is universal for postmenopausal women, but not for elderly men, in whom osteoporosis is also commonly neglected. This study aimed to evaluate vitamin D deficiency and its association with secondary hyperparathyroidism, bone resorption, and bone density in Brazilian men. A total of 120 men, 20-93 years, were evaluated for serum calcium, phosphorus, creatinine, 25-hydroxyvitamin D (25(OH)D), parathyroid hormone, biochemical markers of bone resorption (carboxy-terminal telopeptide, carboxy-terminal peptide of type I collagen), and bone mineral density (dual-energy X-ray absorptiometry)...
February 20, 2017: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28232932/cardiorenal-syndrome-in-western-countries-epidemiology-diagnosis-and-management-approaches
#9
REVIEW
Claudio Ronco, Luca Di Lullo
BACKGROUND: It is well established that a large number of hospitalized patients present various degrees of heart and kidney dysfunction; primary disease of the heart or kidney often involves dysfunction or injury to the other. SUMMARY: Based on above-cited organ cross-talk, the term cardiorenal syndrome (CRS) was proposed. Although CRS was usually referred to as abruption of kidney function following heart injury, it is now clearly established that it can describe negative effects of an impaired renal function on the heart and circulation...
January 2017: Kidney Diseases
https://www.readbyqxmd.com/read/28223837/efficacy-of-low-dose-cinacalcet-on-alternate-days-for-the-treatment-of-secondary-hyperparathyroidism-in-hemodialysis-patients-a-single-center-study
#10
Pongsathorn Gojaseni, Dolnapa Pattarathitinan, Anutra Chittinandana
INTRODUCTION: Cinacalcet is effective in reducing serum parathyroid hormone (PTH) in patients with secondary hyperparathyroidism (HPT). This study focused on testing whether a prescription of low-dose cinacalcet on alternate days could be an option for treatment of secondary HPT. MATERIALS AND METHODS: A retrospective clinical study was conducted on chronic maintenance hemodialysis patients. Patients with secondary HPT who received cinacalcet at a starting dose of 25 mg on alternate days were reviewed (low-dose group)...
2017: International Journal of Nephrology and Renovascular Disease
https://www.readbyqxmd.com/read/28222407/parathyroid-hormone-response-to-severe-vitamin-d-deficiency-is-associated-with-femoral-neck-bone-mineral-density-an-observational-study-of-405-women-with-hip-fracture
#11
Marco Di Monaco, Carlotta Castiglioni, Rosa Tappero
OBJECTIVE: Hip-fracture patients with vitamin D deficiency can have either secondary hyperparathyroidism or normal levels of parathyroid hormone (PTH). We hypothesized that bone mineral density (BMD) could be lower in patients with high PTH levels than in those with normal levels of PTH, irrespectively of the severity of vitamin D depletion. DESIGN: In this cross-sectional study, we examined 405 women who had serum 25-hydroxyvitamin D below 12ng/ml 20.0 ± 5.9 (mean ± SD) days after a hip-fracture...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28222063/extended-release-calcifediol-rayaldee-for-secondary-hyperparathyroidism
#12
(no author information available yet)
No abstract text is available yet for this article.
February 27, 2017: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/28186657/association-of-vitamin-d-metabolites-with-parathyroid-hormone-fibroblast-growth-factor-23-calcium-and-phosphorus-in-dogs-with-various-stages-of-chronic-kidney-disease
#13
V J Parker, L M Harjes, K Dembek, G S Young, D J Chew, R E Toribio
BACKGROUND: Hypovitaminosis D is associated with progression of renal disease, development of renal secondary hyperparathyroidism (RHPT), chronic kidney disease-mineral bone disorder (CKD-MBD), and increased mortality in people with CKD. Despite what is known regarding vitamin D dysregulation in humans with CKD, little is known about vitamin D metabolism in dogs with CKD. OBJECTIVES: The purpose of our study was to further elucidate vitamin D status in dogs with different stages of CKD and to relate it to factors that affect the development of CKD-MBD, including parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), calcium, and phosphorus concentrations...
February 10, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28183082/current-parathyroid-hormone-assays-may-mislead-clinical-decision-making-particularly-in-chronic-kidney-disease-patients-with-secondary-hyperparathyroidism
#14
Berthold Hocher, Lianghong Yin
Preclinical studies in cell culture systems as well as in whole animal chronic kidney disease (CKD) models showed that parathyroid hormone (PTH), oxidized at the 2 methionine residues (positions 8 and 18), caused a loss of function. This was so far not considered in the development of PTH assays used in current clinical practice. Patients with advanced CKD are subject to oxidative stress, and plasma proteins (including PTH) are targets for oxidants. In patients with CKD, a considerable but variable fraction (about 70 to 90%) of measured PTH appears to be oxidized...
February 10, 2017: Nephron
https://www.readbyqxmd.com/read/28170301/influence-of-parathyroidectomy-on-bone-calcium-concentration-evaluation-with-spectral-ct-in-patients-with-secondary-hyperparathyroidism-undergoing-hemodialysis-a-prospective-feasibility-study
#15
Qiang Ma, Zhenghan Yang, Xue Han, Fen Liu, Dechun Su, Haidong Xing
Purpose To use spectral computed tomography (CT) to evaluate the influence of parathyroidectomy (PTX) on calcium concentration in trabecular bone and cortical bone in patients undergoing hemodialysis with secondary hyperparathyroidism. Materials and Methods This study was performed with institutional review board approval. Written consent was obtained from each patient. Thirty-eight men (mean age ± standard deviation, 55.69 years ± 8.05; range, 42-72 years) undergoing maintenance hemodialysis who underwent PTX and 40 patients (mean age, 56...
February 7, 2017: Radiology
https://www.readbyqxmd.com/read/28122587/diseases-associated-with-calcium-sensing-receptor
#16
REVIEW
C Vahe, K Benomar, S Espiard, L Coppin, A Jannin, M F Odou, M C Vantyghem
The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by regulating parathyroid hormone secretion and urinary calcium excretion. The diseases caused by an abnormality of the CaSR are genetically determined or are more rarely acquired. The genetic diseases consist of hyper- or hypocalcemia disorders. Hypercalcaemia disorders are related to inactivating mutations of the CASR gene either heterozygous (autosomal dominant familial benign hypercalcaemia, still named hypocalciuric hypercalcaemia syndrome type 1) or homozygous (severe neonatal hyperparathyroidism)...
January 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28116110/skeletal-findings-in-secondary-hyperparathyroidism
#17
Abhilash Koratala, Vikrampal Bhatti
No abstract text is available yet for this article.
January 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28112766/factors-influencing-serum-hydroxivitamin-d-levels-and-other-bone-metabolism-parameters-in-healthy-older-women
#18
C Trevisan, N Veronese, L Berton, S Carraro, F Bolzetta, M De Rui, F Miotto, E M Inelmen, A Coin, E Perissinotto, E Manzato, G Sergi
OBJECTIVE: Older women have frequently low serum 25-hydroxivitamin D (25[OH]D) concentrations, high parathormone (PTH) levels and low bone mineral density (BMD) values. Endogenous synthesis, dietary habits, sunlight exposure and fat-mass-mediated storage may influence 25(OH)D levels and bone metabolism, but the relevance of these factors in the elderly has yet to be fully elucidated. We aimed to investigate the influence of dietary vitamin D intake and fat mass on serum 25(OH)D levels and bone metabolism in older women...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28107527/effects-of-the-administration-of-25-oh-vitamin-d3-in-an-experimental-model-of-chronic-kidney-disease-in-animals-null-for-1-alpha-hydroxylase
#19
Noelia Torremadé, Milica Bozic, David Goltzman, Elvira Fernandez, José M Valdivielso
The final step in vitamin D activation is catalyzed by 1-alpha-hydroxylase (CYP27B1). Chronic kidney disease (CKD) is characterized by low levels of both 25(OH)D3 and 1,25(OH)2D3 provoking secondary hyperparathyroidism (2HPT). Therefore, treatments with active or native vitamin D compounds are common in CKD to restore 25(OH)D3 levels and also to decrease PTH. This study evaluates the dose of 25(OH)D3 that restores parathyroid hormone (PTH) and calcium levels in a model of CKD in CYP27B1-/- mice. Furthermore, we compare the safety and efficacy of the same dose in CYP27B1+/+ animals...
2017: PloS One
https://www.readbyqxmd.com/read/28098117/denosumab-for-the-treatment-of-bisphosphonate-resistant-hypercalcemia-in-a-hemodialysis-patient
#20
Omar Dahmani, Christine Sophoclis, Malika Kebir, Djemai Bouguern, Aboubacry Sakho, Pascale Demarchi
The acronym of malignancy, iatrogenic, intoxication and immobilization, sarcoidosis, hyperparathyroidism and hyperthyroidism, milk-alkali syndrome, and paget is very helpful in diagnosing hypercalcemia. We report on a 94-year-old patient with history of end-stage renal failure secondary to benign nephroangiosclerosis, who was on maintenance hemodialysis during dialysis, his blood chemistry revealed mild hypercalcemia (2.66 mmol/L) with normal level of intact primary hyperparathyroidism (32.37 ng/mL) mandating the discontinuation of Vitamin D[3]...
January 2017: Saudi Journal of Kidney Diseases and Transplantation
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