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https://www.readbyqxmd.com/read/28549325/graphene-oxide-in-the-water-environment-could-affect-tetracycline-antibiotic-resistance
#1
Mei-Ting Guo, Guo-Sheng Zhang
In recent years, the influence of new materials like nanoparticles in the water environment on biological substances has been widely studied. Antibiotic resistance genes (ARGs) represent a new type of pollutant in the environment. Graphene oxide (GO), as a nano material, because of its unique structure, may have an impact on antibiotic resistance bacteria (ARB) and ARGs; however the research in this area is rarely reported. Therefore, this study mainly investigated the effects of GO on bacterial antibiotic resistance...
May 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28549097/cluster-of-neisseria-gonorrhoeae-isolates-with-high-level-azithromycin-resistance-and-decreased-ceftriaxone-susceptibility-hawaii-2016
#2
Alan R Katz, Alan Y Komeya, Robert D Kirkcaldy, A Christian Whelen, Olusegun O Soge, John R Papp, Ellen N Kersh, Glenn M Wasserman, Norman P O'Connor, Pamela S O'Brien, Douglas T Sato, Eloisa V Maningas, Gail Y Kunimoto, Juval E Tomas
Background.: The Centers for Disease Control and Prevention (CDC) currently recommends dual therapy with ceftriaxone and azithromycin for gonorrhea to ensure effective treatment and slow emergence of antimicrobial resistance. Since 2013, the prevalence of reduced azithromycin susceptibility increased in the United States; however, these strains were highly susceptible to cephalosporins. We report on a cluster of N. gonorrhoeae isolates demonstrating high-level azithromycin resistance, several of which also demonstrated decreased ceftriaxone susceptibility...
May 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28548661/co-evolution-with-staphylococcus-aureus-leads-to-lipopolysaccharide-alterations-in-pseudomonas-aeruginosa
#3
Mikael Tognon, Thilo Köhler, Bartosz G Gdaniec, Youai Hao, Joseph S Lam, Marie Beaume, Alexandre Luscher, Angus Buckling, Christian van Delden
Detrimental and beneficial interactions between co-colonizing bacteria may influence the course of infections. In cystic fibrosis (CF) airways, Staphylococcus aureus prevails in childhood, whereas Pseudomonas aeruginosa progressively predominates thereafter. While a range of interactions has been identified, it is unclear if these represent specific adaptations or correlated responses to other aspects of the environment. Here, we investigate how P. aeruginosa adapts to S. aureus by evolving P. aeruginosa in the presence and absence of S...
May 26, 2017: ISME Journal
https://www.readbyqxmd.com/read/28548487/the-challenge-of-overcoming-antibiotic-resistance-an-adjuvant-approach
#4
Roberta J Melander, Christian Melander
Antibiotic resistance is one of the greatest current threats to human health, and without significant action we face the chilling prospect of a world without effective antibiotics. Although continued effort toward the development of new antibiotics, particularly those with novel mechanisms of action, remains crucial, this alone probably will not be enough to prevail, and it is imperative that additional approaches are also explored. One such approach is the identification of adjuvants that augment the activity of current antibiotics...
May 26, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28548370/current-state-of-a-dual-behavior-of-antimicrobial-peptides-therapeutic-agents-and-promising-delivery-vectors
#5
REVIEW
Urszula Piotrowska, Marcin Sobczak, Ewa Oledzka
Microorganism resistance is an important challenge in modern medicine due to the global uncontrolled use of antibiotics. Natural and synthetic antimicrobial peptides (AMPs) symbolize a new family of antibiotics, which have stimulated research and clinical interest as new therapeutic options for infections. They represent one of the most promising antimicrobial substances, due to their broad spectrum of biological activity, against bacteria, fungi, protozoa, viruses, yeast and even tumour cells. Besides, being antimicrobial, AMPs have been shown to bind and neutralize bacterial endotoxins, as well as possess immunomodulatory, anti-inflammatory, wound-healing, angiogenic and antitumour properties...
May 26, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28547678/immunosuppression-drug-therapy-in-lung-transplantation-for-cystic-fibrosis
#6
REVIEW
Pamela Burcham, Lisa Sarzynski, Sabrina Khalfoun, Kimberly J Novak, Julie C Miller, Dmitry Tumin, Don Hayes
Cystic fibrosis (CF) is a common indication for lung transplantation (LTx) in children and adults with severe and irreversible lung disease. In the setting of LTx in the CF population, immunosuppressive medications are used to prevent allograft rejection despite the majority of these patients being chronically infected with numerous, and often antibiotic-resistant, pathogens. There is limited evidence for the optimal post-LTx immunosuppression regimen in patients with CF, particularly in children. This article provides a review of immunosuppression regimens in the pediatric and adult CF post-LTx population, investigating drug dosing and monitoring, and medication combinations...
May 25, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28547390/mono-substitution-effects-on-antimicrobial-activity-of-stapled-heptapeptides
#7
Huy X Luong, Do-Hee Kim, Ngoan T Mai, Bong-Jin Lee, Young-Woo Kim
We previously reported a de novo design of antimicrobial heptapeptide helices using Verdine's all-hydrocarbon peptide stapling system. One of the important structure-activity relationships we found from these previous studies was that extending of the hydrophobic face by replacing of alanine with leucine in positon 5 increases antimicrobial activity. In this study, to further improve the activity profile of this peptide series, we investigated the substitution effects of position 5 on conformational and proteolytic stability as well as antimicrobial and hemolytic activity...
May 25, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28546984/the-comparison-of-printed-resources-bacterial-contamination-in-libraries-of-al-zahra-hospital-and-sciences-faculty-of-isfahan-university-and-the-determination-of-their-antibiotic-sensitivity-pattern
#8
Hosein Rafiei, Mostafa Chadeganipour, Rezvan Ojaghi, Mohammad Reza Maracy, Rasool Nouri
INTRODUCTION: During the library loan process, the printed resources can be a carrier of pathogenic bacteria. In this study, it was tried to compare the Bacterial Contamination Rates and their antibiotic sensitivity pattern in printed resources of a hospital and a non-hospital library. METHODS: This is a cross-sectional study. Returning books from the Al-Zahra hospital library and library of Sciences faculty of Isfahan University provides the research community...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28546830/antibiotic-resistance-serogroups-virulence-genes-and-phylogenetic-groups-of-escherichia-coli-isolated-from-yaks-with-diarrhea-in-qinghai-plateau-china
#9
Mujeeb Ur Rehman, Hui Zhang, Muhammad Kashif Iqbal, Khalid Mehmood, Shucheng Huang, Fazul Nabi, Houqiang Luo, Yanfang Lan, Jiakui Li
BACKGROUND: Ruminants serve as one of the most important reservoirs for pathogenic Escherichia coli. Infection with E. coli, a foodborne enteropathogen, can lead to asymptomatic infections that can cause life-threatening complications in humans. Therefore, from a clinical and human health perspective, it is important to know which virulence genes, phylogenetic groups, serogroups, and antibiotic resistance patterns are present in E. coli strains in yaks with diarrheic infections. METHODS: Two-hundred and ninety-two rectal swabs were collected from diarrheic yaks in Qinghai Plateau, China...
2017: Gut Pathogens
https://www.readbyqxmd.com/read/28546829/vinasse-fertirrigation-alters-soil-resistome-dynamics-an-analysis-based-on-metagenomic-profiles
#10
Lucas P P Braga, Rafael F Alves, Marina T F Dellias, Acacio A Navarrete, Thiago O Basso, Siu M Tsai
Every year around 300 Gl of vinasse, a by-product of ethanol distillation in sugarcane mills, are flushed into more than 9 Mha of sugarcane cropland in Brazil. This practice links fermentation waste management to fertilization for plant biomass production, and it is known as fertirrigation. Here we evaluate public datasets of soil metagenomes mining for changes in antibiotic resistance genes (ARGs) of soils from sugarcane mesocosms repeatedly amended with vinasse. The metagenomes were annotated using the ResFam database...
2017: BioData Mining
https://www.readbyqxmd.com/read/28546690/update-on-the-epidemiology-and-antibiotic-resistance-of-ocular-infections
#11
Darlene Miller
PURPOSE: The purpose of this review is to provide an update on the epidemiology and current antibiotic-resistant threats in ophthalmology. METHODS: Trends in frequency and antibiotic-nonsusceptible profiles during an 11 year-period (2005-2015) were evaluated and compared with the 5-year Antibiotic Resistance Monitoring in Ocular Microorganism (ARMOR) study. RESULTS: Trends in the current review confirmed the continued high rates of fluoroquinolone nonsusceptbility circulating among ocular methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, methicillin-resistant S...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546688/collagen-cross-linking-for-microbial-keratitis
#12
Prashant Garg, Sujata Das, Aravind Roy
Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. The treatment also induces formation of inter- and intra-fibrillar bonds, thereby making the corneal collagen resistant to the action of proteases arresting stromal melt...
January 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28546075/antimicrobial-storage-and-antibiotic-knowledge-in-the-community-a-cross-sectional-pilot-study-in-north-western-angola
#13
Joana Cortez, Edite Rosário, João E Pires, João Taborda Lopes, Moisés Francisco, Erika Vlieghe, Miguel Brito
BACKGROUND: Antimicrobials are drugs that were once lifesavers and mainly curative. Nowadays their value is increasingly under pressure because of the fast and worldwide emergence of antimicrobial resistance, which, in low resources settings, frequently occurs in microorganisms that are likely to be transmitted in the community. METHODS: A cross-sectional pilot study including 102 households within the 10th HDSS round in Dande, Bengo Province, Angola. RESULTS: From the total 102 households piloted, 77...
May 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28545990/retrospective-survey-of-mcr-1-and-mcr-2-in-german-pig-fattening-farms-2011-2012
#14
Nicole Roschanski, Linda Falgenhauer, Mirjam Grobbel, Sebastian Guenther, Lothar Kreienbrock, Can Imirzalioglu, Uwe Roesler
In November 2015, the first plasmid-encoded colistin resistance gene, mcr-1, was described in animals and in humans in China. Subsequently, a multitude of further studies was performed and quite recently the global spread of mcr-1 as well as the occurrence of a new gene variant, mcr-2, was reported. To obtain an overview of the occurrence of the colistin resistance genes mcr-1 and mcr-2 in German pig farms, a retrospective study, including 436 boot swab and pooled faeces samples collected from 58 pig-fattening farms throughout Germany, was performed...
May 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28545327/designing-of-inhibitors-against-ctx-m-15-type-%C3%AE-lactamase-potential-drug-candidate-against-%C3%AE-lactamases-producing-multi-drug-resistant-bacteria
#15
Abid Ali, Danishuddin, Lubna Maryam, Gaurava Srivastava, Ashok Sharma, Asad U Khan
CTX-M-15 are the most prevalent types of β-lactamases that hydrolyze almost all antibiotics of β-lactam group lead to multiple-antibiotic resistance in bacteria. Three β-lactam inhibitors are available for use in combination with different antibiotics of cephalosporine group against the CTX-M-15 producing strains. Therefore, strategies to identify novel anti β-lactamase agents with specific mechanisms of action are theneed of an hour. In this study, we screened three novel non-β-lactaminhibitors against CTX-M-15 by multi-step virtual screening approach...
May 26, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28545189/outcomes-of-a-randomized-controlled-trial-comparing-modified-high-dose-omeprazole-and-amoxicillin-triple-therapy-with-standard-triple-therapy-for-helicobacter-pylori-eradication
#16
Kitti Chunlertlith, Uaepong Limpapanasit, Pisaln Mairiang, Suda Vannaprasaht, Wichittra Tassaneeyakul, Apichat Sangchan, Kookwan Sawadpanich, Tanita Suttichaimongkol, Jamrus Pongpit, Moragot Pattarapongsin
Background: Helicobacter pylori (H. pylori) infection is related to peptic ulcer diseases and gastric cancer and eradication of H. pylori should be expected to decrease the risk of their development. Factors affecting H. pylori eradication are antibiotic resistance, CYP2C19 genotypes, drug regimen and patient compliance. Increment of omeprazole and amoxicillin dosage in clarithromycin-containing triple therapy regimen may overcome these problems and may be a better choice than the conventional clarithromycin-containing triple therapy regimen...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28544761/composites-of-bacterial-cellulose-and-small-molecule-decorated-gold-nanoparticles-for-treating-gram-negative-bacteria-infected-wounds
#17
Ying Li, Yue Tian, Wenshu Zheng, Yan Feng, Rong Huang, Jingxin Shao, Rongbing Tang, Peng Wang, Yuexiao Jia, Jiangjiang Zhang, Wenfu Zheng, Guang Yang, Xingyu Jiang
Bacterial infections, especially multidrug-resistant bacterial infections, are an increasingly serious problem in the field of wound healing. Herein, bacterial cellulose (BC) decorated by 4,6-diamino-2-pyrimidinethiol (DAPT)-modified gold nanoparticles (Au-DAPT NPs) is presented as a dressing (BC-Au-DAPT nanocomposites) for treating bacterially infected wounds. BC-Au-DAPT nanocomposites have better efficacy (measured in terms of reduced minimum inhibition concentration) than most of the antibiotics (cefazolin/sulfamethoxazole) against Gram-negative bacteria, while maintaining excellent physicochemical properties including water uptake capability, mechanical strain, and biocompatibility...
May 23, 2017: Small
https://www.readbyqxmd.com/read/28544416/global-analysis-of-strategies-to-tackle-antimicrobial-resistance
#18
Funke Adeniji
BACKGROUND: Antimicrobial resistance (AMR) is a global public health issue driven by inappropriate use of antimicrobials resulting in decreased efficacy on the background of an extremely limited pipeline for new antibiotics. We sought to analyse the effectiveness of key policies and strategies in tackling AMR globally and identify gaps in these. METHOD: The scope, magnitude, history and drivers of AMR were reviewed using supporting evidence. Our methodology included a literature review and semi-structured survey, whilst the analyses process was guided by an adapted health policy analyses framework...
May 22, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28544285/salmonella-typhi-genomics-envisaging-the-future-of-typhoid-eradication
#19
REVIEW
Kien-Pong Yap, Kwai Lin Thong
Next-generation whole genome sequencing has revolutionized the study of infectious diseases in recent years. The availability of genome sequences and its understanding have transformed the field of molecular microbiology, epidemiology, infection treatments and vaccine developments. We review the key findings of the publicly accessible genomes of Salmonella enterica serovar Typhi since the first complete genome to the most recent release of thousands of S. typhi genomes, which remarkably shape the genomic research of S...
May 24, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28544222/usefulness-of-detection-of-clarithromycin-resistant-helicobacter-pylori-from-fecal-specimens-for-young-adults-treated-with-eradication-therapy
#20
Takako Osaki, Katsuhiro Mabe, Cynthia Zaman, Hideo Yonezawa, Masumi Okuda, Kenji Amagai, Shinji Fujieda, Mitsuhide Goto, Wataru Shibata, Mototsugu Kato, Shigeru Kamiya
BACKGROUND: To prevent Helicobacter pylori infection in the younger generation, it is necessary to investigate the prevalence of antibiotic-resistant H. pylori. OBJECTIVE: The aim of this study was to evaluate the method of PCR-based sequencing to detect clarithromycin (CAM) resistance-associated mutations using fecal samples as a noninvasive method. METHODS: DNA extracted from fecal specimens and isolates from gastric biopsy specimens were collected from patients with H...
May 22, 2017: Helicobacter
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