Michael W Donnino, Katherine M Berg, Jacob Vine, Lakshman Balaji, Noa Berlin, Michael N Cocchi, Ari Moskowitz, Maureen Chase, Franklin Li, Shivani Mehta, Jeremy Silverman, Stanley Heydrick, Xiaowen Liu, Anne V Grossestreuer
INTRODUCTION: Thiamine is a key cofactor for aerobic metabolism, previously shown to improve mortality and neurological outcomes in a mouse model of cardiac arrest. We hypothesized that thiamine would decrease lactate and improve outcomes in post-arrest patients. METHODS: Single center, randomized, blinded, placebo-controlled, Phase II trial of thiamine in adults within 4.5 hours of return of spontaneous circulation after out-of-hospital cardiac arrest (OHCA), with coma and lactate ≥ 3 mmol/L...
February 28, 2024: Resuscitation