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https://www.readbyqxmd.com/read/28526229/cost-benefit-analysis-of-robotic-surgery-in-gynaecological-oncology
#1
REVIEW
Christos Iavazzo, Ioannis D Gkegkes
Robotic approach is a rather new technique that can be used to optimise the management of patients with gynaecological cancer. However, concerns have been raised regarding the cost of such an approach compared to laparoscopic or open techniques. The aim of our chapter is to review the data of papers published so far that analyse the cost of robotic gynaecological oncology. A systematic review of the current literature was performed trying to assess the cost of the robotic technique including parameters that affect it and ways to minimise it in favour of the patients and health care systems...
April 23, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28525846/exploring-the-clonal-evolution-of-cd133-aldehyde-dehydrogenase-1-aldh1-positive-cancer-stem-like-cells-from-primary-to-recurrent-high-grade-serous-ovarian-cancer-hgsoc-a-study-of-the-ovarian-cancer-therapy-innovative-models-prolong-survival-octips-consortium
#2
Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, Iulia Ignat, Mandy Stanske, Adriaan Vanderstichele, Ram N Ganapathi, Jacek Glajzer, Hagen Kulbe, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Pierluigi Benedetti Panici, Charlie Gourley, Hani Gabra, Mirjana Kessler, Jalid Sehouli, Silvia Darb-Esfahani, Elena Ioana Braicu
BACKGROUND: High-grade serous ovarian cancer (HGSOC) causes 80% of all ovarian cancer (OC) deaths. In this setting, the role of cancer stem-like cells (CSCs) is still unclear. In particular, the evolution of CSC biomarkers from primary (pOC) to recurrent (rOC) HGSOCs is unknown. Aim of this study was to investigate changes in CD133 and aldehyde dehydrogenase-1 (ALDH1) CSC biomarker expression in pOC and rOC HGSOCs. METHODS: Two-hundred and twenty-four pOC and rOC intrapatient paired tissue samples derived from 112 HGSOC patients were evaluated for CD133 and ALDH1 expression using immunohistochemistry (IHC); pOCs and rOCs were compared for CD133 and/or ALDH1 levels...
May 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28521459/cisplatin-regulates-cell-autophagy-in-endometrial-cancer-cells-via-the-pi3k-akt-mtor-signalling-pathway
#3
Qiongyan Lin, Yifeng Wang, Dunjin Chen, Xiujie Sheng, Juan Liu, Hanzhen Xiong
Endometrial cancer is the most common gynaecological malignancy encountered in developed countries and the second most common in the developing world. The five-year survival rate of patients with endometrial cancer diagnosed at a late stage is <30%. Therefore, it is critical to develop a suitable chemotherapeutic regimen for late-stage endometrial cancer. Cisplatin (CDDP) is a first-line chemotherapeutic drug for endometrial cancer chemotherapy. The present study investigated the molecular mechanism underlying the effect of CDDP on endometrial cancer from the perspective of cell autophagy...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28517240/imaging-after-treatment-in-uterine-malignancies-spectrum-of-normal-findings-and-most-common-complications
#4
REVIEW
Maura Miccò, Anna Maria Telesca, Benedetta Gui, Pier Paolo Grimaldi, Francesco Cambi, Maria Giulia Marini, Anna Lia Valentini, Lorenzo Bonomo
Uterine malignancies account for the majority of gynaecologic cancers. Different treatment options are available depending on histology, disease grade and stage. Hysterectomy is the most frequent surgical procedure. Chemotherapy and radiation therapy (CRT) represents the preferred therapeutic choice for locally advanced uterine and cervical malignancies. Imaging of the female pelvis following these treatments is particularly challenging due to alteration of the normal anatomy. Radiologists should be familiar with both the expected post-treatment imaging findings and the imaging features of possible complications to make the correct interpretation and avoid possible pitfalls...
May 18, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28515524/spinal-anaesthesia-for-a-caesarean-section-in-a-patient-with-paraneoplastic-cerebellar-ataxia
#5
Ayca Tas Tuna, Fatih Sahin, Dilcan Kotan, Ali Fuat Erdem, Meltem Baykara, Tuba Duzcan
Paraneoplastic cerebellar ataxia (PCA) is most frequently observed in gynaecological cancers, small cell lung cancer, breast cancer, Hodgkin's lymphoma, cancer testis or malignant thymoma. In the literature, there is no data related to the effects of PCA during pregnancy or reports on the effects of anaesthesia in patients with PCA. We present management of a pregnant woman with PCA who was suddenly unable to walk with PCA and for whom effective spinal anaesthesia was performed for an elective caesarean section with no complications...
April 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28511371/study-of-serum-total-psa-and-free-psa-as-an-oncological-marker-in-breast-tumour
#6
Elteza Tahjiba Jahir, Runi Devi, Bibhuti Bhushan Borthakur
INTRODUCTION: Breast Cancer (BC) cases are rising alarmingly all over the world and India is not an exception. This rising trend is due to an increased age at first child birth, decreased breast feeding, and the changing lifestyle mostly in urban India. With the advent of more sensitive methodologies and research works in this field, it has been suggested that Prostate Specific Antigen (PSA) plays an important role in the pathogenesis of breast cancer besides other established tumour markers...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28509325/an-alternative-approach-to-gynecological-wound-healing
#7
Jakub Rzepka, Katarzyna Mosoń, Romuald Dębski
An 89-year-old woman was reffered to our Clinic with vulvar cancer. She also suffered from obesity [with body mass index (BMI) 35 kg/m2], persistent hypertension, diabetes mellitus type 2 treated with oral medications. In 2015 she underwent a surgery due to endometrial carcinoma. Total abdominal hysterectomy with bilateral salphingoophorectomy, omentectomy and pelvical node dissection was performed (histopathology revealed adenocarcinoma serosum G2; FIGO stage Ib). In January 2016 after vulvar ulceration biopsy plano-epithelial squamous vulvar cancer was diagnosed...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28497333/next-generation-sequencing-based-genomic-profiling-of-brain-metastases-of-primary-ovarian-cancer-identifies-high-number-of-brca-mutations
#8
S Balendran, S Liebmann-Reindl, A S Berghoff, T Reischer, N Popitsch, C B Geier, L Kenner, P Birner, B Streubel, M Preusser
Ovarian cancer represents the most common gynaecological malignancy and has the highest mortality of all female reproductive cancers. It has a rare predilection to develop brain metastases (BM). In this study, we evaluated the mutational profile of ovarian cancer metastases through Next-Generation Sequencing (NGS) with the aim of identifying potential clinically actionable genetic alterations with options for small molecule targeted therapy. Library preparation was conducted using Illumina TruSight Rapid Capture Kit in combination with a cancer specific enrichment kit covering 94 genes...
May 11, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28484898/virus-induced-cancers-of-the-skin-and-mucosa-are-we-dealing-with-smoking-guns-or-smoke-and-mirrors-in-the-operating-theatre
#9
Peter K C Goon, Patrick K Y Goon, Eunice K H Tan, Robin A F Crawford, Nick J Levell, Holger Sudhoff
INTRODUCTION: Human papillomavirus (HPV) alone is thought to cause ~610,000 cases of cancer per year, and is the dominant aetiological agent for ano-genital (esp. cervical) and head and neck cancers (esp. oropharyngeal). Merkel cell polyomavirus (MCV) is a more recently discovered virus which causes Merkel cell carcinoma, a rare but highly aggressive skin malignancy. METHODS: We explored the available published evidence to see if transmission of live HPV or MCV virus in smoke generated by laser or diathermy was feasible, and would pose an infection risk...
May 8, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28482877/electronic-patient-self-reporting-of-adverse-events-patient-information-and-advice-erapid-a-randomised-controlled-trial-in-systemic-cancer-treatment
#10
Kate Absolom, Patricia Holch, Lorraine Warrington, Faye Samy, Claire Hulme, Jenny Hewison, Carolyn Morris, Leon Bamforth, Mark Conner, Julia Brown, Galina Velikova
BACKGROUND: eRAPID (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice) is an internet based system for patients to self-report symptoms and side effects (adverse events or AE) of cancer treatments. eRAPID allows AE reporting from home and patient reported data is accessible via Electronic Patient Records (EPR) for use in routine care. The system can generate alerts to clinical teams for severe AE and provides patient advice on managing mild AEs. The overall aims of eRAPID are to improve the safe delivery of cancer treatments, enhance patient care and standardise AE documentation...
May 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28470944/patterns-of-practice-survey-for-brachytherapy-for-cervix-cancer-in-australia-and-new-zealand
#11
Karen Lim, Sylvia van Dyk, Pearly Khaw, Jacqueline Veera, Linda Mileshkin, Lucy Ohanessian, Michelle Harrison, Shalini K Vinod
INTRODUCTION: The purpose of this survey was to explore the current patterns of practice for brachytherapy in cervix cancer in Australia and New Zealand. The survey was also intended to explore clinician attitudes towards image-guided adaptive brachytherapy (IGABT) and identify barriers to the implementation of IGABT. METHODS: Electronic surveys were sent to all radiotherapy centres in Australia and New Zealand under collaboration with Australia New Zealand Gynaecology and Oncology Group (ANZGOG), in order to identify patterns of radiotherapy practice...
May 4, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28469316/cervical-cytopathological-changes-among-women-with-vaginal-discharge-attending-teaching-hospital
#12
Magdi M Salih, Fatma Tage El Sir AlHag, Mohammed Ahmed Khalifa, Abdulla H El Nabi
AIMS: To find cytology changes among women attending obstetrics and gynaecology clinic with complaints of vaginal discharges. SETTINGS AND DESIGN: This descriptive hospital-based cytological study was conducted at the outpatient clinic of the obstetrics and gynaecology department. MATERIALS AND METHODS: Two hundred women with complaints of vaginal discharge were selected. Their detailed histories were documented on a special request form. Pap smears were then obtained and sent for cytological examination to the cytopathology department...
April 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28466456/new-procedures-for-the-identification-of-sentinel-lymph-node-shaping-the-horizon-of-future-management-in-early-stage-uterine-cervical-cancer
#13
Diego Rossetti, Salvatore Giovanni Vitale, Alessandro Tropea, Antonio Biondi, Antonio Simone Laganà
Lymph node metastasis is one of the most important prognostic factors for uterine cervical cancer, although lymph node status is not part of the International Federation of Gynaecology and Obstetrics (FIGO) staging. Considering the increasing attention about the topic, we performed a comprehensive review of the literature, to assess the accuracy of real-time fluorescence sentinel lymph node (SLN) for the detection of nodal metastases in patients with early stage cervical cancer (ESCC). In this work, we discuss the different techniques for SLN mapping and the accuracy of each one of them and, basing on these data, summarize the most important recommendations...
May 2, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28460202/neoplastic-sigmoid-uterine-fistula-an-exceptional-complication-of-large-intestine-cancer
#14
G Zanghì, V Leanza, R Vecchio, A D'Agati, S Cordova, N M Rinzivillo, M Lodato, G Leanza
Neoplastic sigmoid-uterine fistula is an extremely rare condition because the uterus is a thick and muscular organ. A 74-year-old woman was admitted to the First Aid Station suffering from abdominal pain and foul smelling vaginal discharge. Gynaecological examination showed fecal drainage from the cervical orifice, while the uterus was regular in size but very firm and painful. Ovaries and fallopian tubes were not palpable owing to abdominal tenderness. Ultrasounds reveled inhomogeneous thickening of uterine cavity, without detecting fistula...
January 2017: Il Giornale di Chirurgia
https://www.readbyqxmd.com/read/28457647/british-gynaecological-cancer-society-bgcs-epithelial-ovarian-fallopian-tube-primary-peritoneal-cancer-guidelines-recommendations-for-practice
#15
EDITORIAL
Christina Fotopoulou, Marcia Hall, Derek Cruickshank, Hani Gabra, Raji Ganesan, Cathy Hughes, Sean Kehoe, Jonathan Ledermann, Jo Morrison, Raj Naik, Phil Rolland, Sudha Sundar
No abstract text is available yet for this article.
April 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28451393/the-circulating-microrna-200-family-in-whole-blood-are-potential-biomarkers-for-high-grade-serous-epithelial-ovarian-cancer
#16
Adam Pendlebury, Natalie J Hannan, Natalie Binder, Sally Beard, Monica Mcgauran, Peter Grant, Stephen Tong, Clare L Whitehead
Epithelial ovarian cancer (EOC) is the leading cause of mortality with regard to gynaecological cancer. There is no effective biomarker and therefore prognosis is poor as the majority of cases are not diagnosed until advanced disease is present. MicroRNAs (miRs) are dysregulated in ovarian cancer tissue and are present in the circulation. The aim of the present study was to investigate whether circulating miRs from the miR-200 family served as potential candidate biomarkers for the early detection of EOC. Whole blood and ovarian tissue were collected from women with early (stage I/II, n=4), advanced EOC (stage III/IV, n=4), and women with benign ovarian masses (n=5)...
March 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28444736/selective-progesterone-receptor-modulators-sprms-for-uterine-fibroids
#17
REVIEW
Ally Murji, Lucy Whitaker, Tiffany L Chow, Mara L Sobel
BACKGROUND: Uterine fibroids are smooth muscle tumours arising from the uterus. These tumours, although benign, are commonly associated with abnormal uterine bleeding, bulk symptoms and reproductive dysfunction. The importance of progesterone in fibroid pathogenesis supports selective progesterone receptor modulators (SPRMs) as effective treatment. Both biochemical and clinical evidence suggests that SPRMs may reduce fibroid growth and ameliorate symptoms. SPRMs can cause unique histological changes to the endometrium that are not related to cancer, are not precancerous and have been found to be benign and reversible...
April 26, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28441255/european-society-of-gynaecological-oncology-guidelines-for-the-management-of-patients-with-vulvar-cancer
#18
Maaike H M Oonk, François Planchamp, Peter Baldwin, Mariusz Bidzinski, Mats Brännström, Fabio Landoni, Sven Mahner, Umesh Mahantshetty, Mansoor Mirza, Cordula Petersen, Denis Querleu, Sigrid Regauer, Lukas Rob, Roman Rouzier, Elena Ulrikh, Jacobus van der Velden, Ignace Vergote, Linn Woelber, Ate G J van der Zee
OBJECTIVE: The aim of this study was to develop clinically relevant and evidence-based guidelines as part of European Society of Gynaecological Oncology's mission to improve the quality of care for women with gynecologic cancers across Europe. METHODS: The European Society of Gynaecological Oncology Council nominated an international development group made of practicing clinicians who provide care to patients with vulvar cancer and have demonstrated leadership and interest in the management of patients with vulvar cancer (18 experts across Europe)...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28437632/bgcs-uterine-cancer-guidelines-recommendations-for-practice
#19
REVIEW
Sudha Sundar, Janos Balega, Emma Crosbie, Alasdair Drake, Richard Edmondson, Christina Fotopoulou, Ioannis Gallos, Raji Ganesan, Janesh Gupta, Nick Johnson, Sarah Kitson, Michelle Mackintosh, Pierre Martin-Hirsch, Tracie Miles, Saeed Rafii, Nick Reed, Phil Rolland, Kavita Singh, Vanitha Sivalingam, Axel Walther
The British Gynaecological Cancer Society has issued the first Endometrial (Uterine) Cancer guidelines as recommendation for practice for the UK.
April 13, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28436097/the-vaginal-microbiome-and-gynaecological-cancer-exercise-caution-when-considering-causation
#20
Neal C Ramchander, Emma J Crosbie
Genital infection with high-risk human papillomavirus (HPV) is extremely common in young, sexually active women, but most infections are transient and clear without ever causing disease. Persistent infection causes premalignant cervical intraepithelial neoplasia (CIN), which, if left untreated, can undergo malignant transformation and become invasive cancer. Cervical cancer is thus considered a late, rare consequence of persistent high-risk HPV infection (Crosbie et al. Lancet 2013; 382:889-99). Factors that influence the acquisition of genital HPV and the rate of its natural clearance are therefore important in the pathogenesis of cervical cancer...
April 24, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
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