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https://www.readbyqxmd.com/read/30025230/clinical-outcomes-of-adolescents-and-young-adults-with-advanced-solid-tumours-participating-in-phase-i-trials
#1
Raghav Sundar, Terri McVeigh, David Dolling, Ann Petruckevitch, Nikolaos Diamantis, Joo Ern Ang, Maxime Chenard-Poiriér, Dearbhaile Collins, Joline Lim, Malaka Ameratunga, Khurum Khan, Stan B Kaye, Udai Banerji, Juanita Lopez, Angela J George, Johann S de Bono, Winette T van der Graaf
BACKGROUND: Adolescent and young adult (AYA) patients with advanced solid tumours are often considered for phase I clinical trials with novel agents. The outcome of AYAs in these trials have not been described before. AIM: To study the outcome of AYA patients in phase I clinical trials. METHODS: Clinical trial data of AYAs (defined as aged 15-39 years at diagnosis) treated at the Drug Development Unit, Royal Marsden Hospital, between 2002 and 2016, were analysed...
July 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/30014192/knowledge-fatigue-and-cognitive-factors-as-predictors-of-lymphoedema-risk-reduction-behaviours-in-women-with-cancer
#2
Miyako Tsuchiya, Mariko Masujima, Tomoyasu Kato, Shun-Ichi Ikeda, Chikako Shimizu, Takayuki Kinoshita, Sho Shiino, Makiko Suzuki, Miki Mori, Miyako Takahashi
OBJECTIVE: To identify social-cognitive factors predicting lymphoedema risk-reduction behaviours (hereafter, self-care) after discharge among patients in Japan with breast or gynaecological cancers, using the extended model of the theory of planned behaviour. METHODS: A cross-sectional questionnaire study was conducted in an oncology hospital. Items measured were (1) knowledge about self-care; (2) the Cancer Fatigue Scale; (3) social-cognitive factors in the theory of planned behaviour (attitudes, subjective norms, and perceived behavioural control); (4) self-care (limb hygiene, observation, articular movement, recommended risk-reduction behaviours in daily life, and diet and weight control); and (5) demographics...
July 16, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/30011887/potential-for-mitochondrial-dna-sequencing-in-the-differential-diagnosis-of-gynaecological-malignancies
#3
REVIEW
Anna Myriam Perrone, Giulia Girolimetti, Martina Procaccini, Lorena Marchio, Alessandra Livi, Giulia Borghese, Anna Maria Porcelli, Pierandrea De Iaco, Giuseppe Gasparre
In the event of multiple synchronous gynecological lesions, a fundamental piece of information to determine patient management, prognosis, and therapeutic regimen choice is whether the simultaneous malignancies arise independently or as a result of metastatic dissemination. An example of synchronous primary tumors of the female genital tract most frequently described are ovarian and endometrial cancers. Surgical findings and histopathological examination aimed at resolving this conundrum may be aided by molecular analyses, although they are too often inconclusive...
July 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30003349/a-minimally-invasive-approach-for-peritonectomy-procedures-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-limited-peritoneal-carcinomatosis-the-american-society-of-peritoneal-surface-malignancies-aspsm-multi-institution-analysis
#4
A Arjona-Sanchez, J Esquivel, O Glehen, G Passot, K K Turaga, D Labow, S Rufian-Peña, R Morales, K van der Speeten
BACKGROUND: Minimally invasive surgery is playing an increasing role in the treatment of patients with gastrointestinal and gynaecological malignancies as the data show reduced morbidity, faster recovery and similar oncological outcome when compared to open procedures. MATERIALS AND METHODS: The American Society of Peritoneal Surface Malignancies (ASPSM) conducted a retrospective study to analyse peritonectomy procedures and HIPEC done via the laparoscopic route...
July 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29996852/evaluating-the-role-of-clinical-officers-in-providing-reproductive-health-services-in-kenya
#5
Marianne Corine Darwinkel, Julius Maina Nduru, Reuben Waswa Nabie, John Anzetse Aswani
BACKGROUND: Most sub-Saharan African countries have too few reproductive health (RH) specialists, resulting in high RH-related mortality and morbidity. In Kenya, task sharing in RH began in 2002, with the training of clinical officer(s)-reproductive health (CORH). Little is known about them and the extent of their role in the health system. METHODS: In 2016, we conducted a retrospective, quantitative two-stage study in Kenya to evaluate the use of CORH and 28 of their curriculum-derived RH competencies, to determine their contribution to expanded access to RH care...
July 11, 2018: Human Resources for Health
https://www.readbyqxmd.com/read/29992040/erapid-electronic-patient-self-reporting-of-adverse-events-patient-information-and-advice-a-pilot-study-protocol-in-pelvic-radiotherapy
#6
Patricia Holch, Simon Pini, Ann M Henry, Susan Davidson, Jacki Routledge, Julia Brown, Kate Absolom, Alexandra Gilbert, Kevin Franks, Claire Hulme, Carolyn Morris, Galina Velikova
Background: An estimated 17,000 patients are treated annually in the UK with radical radiotherapy (RT) for pelvic cancer. New treatment approaches in RT have increased survivorship and changed the subjective toxicity profile for patients who experience acute and long-term pelvic-related adverse events (AE). Multi-disciplinary follow-up creates difficulty for monitoring and responding to these events during treatment and beyond. Originally developed for use in systemic oncology therapy eRAPID (electronic patient self-Reporting of Adverse-events: Patient Information and aDvice) is an online system for patients to report AEs from home...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/29987401/imaging-strategy-in-recurrent-ovarian-cancer-a-practical-review
#7
REVIEW
Lucia Manganaro, Silvia Gigli, Amanda Antonelli, Matteo Saldari, Federica Tomao, Claudia Marchetti, Emanuela Anastasi, Andrea Laghi
Ovarian cancer is one of the most aggressive gynaecologic malignancies in women worldwide. The lack of proper screening programs and the characteristic abdominal spreading with minimal clinical symptoms give rise of its high lethality. Most patients show advanced disease at diagnosis and have a poor prognosis. The surveillance of ovarian cancer patients after initial treatment is a challenging question in clinical practice and there is no consensus in literature about the most appropriate follow-up strategy for these women...
July 10, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29984416/euxanthone-inhibits-glycolysis-and-triggers-mitochondria-mediated-apoptosis-by-targeting-hexokinase-2-in-epithelial-ovarian-cancer
#8
Jun Zou, Yamei Wang, Mingdi Liu, Xiushu Huang, Wenjian Zheng, Qian Gao, Haijing Wang
Epithelial ovarian cancer (EOC) is one of the most prevalent gynaecological cancers. Euxanthone, an active ingredient of the medicinal plant Polygala caudata, exhibits a selective cytotoxic effect in tumour cells. The present study was aimed to determine whether euxanthone could suppress ovarian tumour growth, and to study the relevant mechanism. Two EOC cell lines, SKOV3 and A2780, were used as the in vitro model and treated with euxanthone. Cell viability and apoptosis were assayed using Cell Counting Kit-8 (CCK-8) and Annexin-V FITC/PI staining, respectively...
July 8, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29981163/a-nationwide-cohort-study-on-the-risk-of-non-gynaecological-cancers-in-women-with-surgically-verified-endometriosis
#9
Liisu Saavalainen, Heini Lassus, Anna But, Aila Tiitinen, Päivi Härkki, Mika Gissler, Oskari Heikinheimo, Eero Pukkala
We assessed the association of surgically verified endometriosis and risk of non-gynaecological cancers according to the type of endometriosis (i.e. ovarian, peritoneal, and deep infiltrating endometriosis). All diagnoses of endometriosis combined with relevant procedural codes were identified from the Finnish Hospital Discharge Register 1987-2012. Non-gynaecological cancers diagnosed after the endometriosis diagnosis were obtained from the Finnish Cancer Registry. The cohort of 49,933 women with surgically verified endometriosis and the sub-cohorts of ovarian (n=23,210), peritoneal (n=20,187), and deep infiltrating (n=2,372) endometriosis were analysed separately...
July 7, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29980546/lifestyle-socioeconomic-status-and-healthcare-seeking-among-women-with-gynaecological-cancer-alarm-symptoms-a-combined-questionnaire-based-and-register-based-population-study
#10
Kirubakaran Balasubramaniam, Sandra Elnegaard, Sanne Rasmussen, Peter Fentz Haastrup, René dePont Christensen, Jens Søndergaard, Dorte Ejg Jarbøl
OBJECTIVES: To determine the proportion of contacts to general practitioner (GP) with recent onset gynaecological cancer alarm symptoms (pelvic pain, postmenopausal bleeding, bleeding during intercourse or pain during intercourse) and to analyse the associations between lifestyle factors, socioeconomic status and GP contact for these symptoms. DESIGN: Cross-sectional survey combined with data from national registers. SETTING: The general Danish population...
July 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29978593/patient-initiated-follow-up-affects-fear-of-recurrence-and-health-care-use-a-randomized-trial-in-early-stage-endometrial-cancer
#11
M M Jeppesen, P T Jensen, D G Hansen, R D Christensen, O Mogensen
OBJECTIVE: To test the hypothesis that patient-initiated follow-up reduces fear of cancer recurrence (FCR) and health care use when compared to traditional hospital-based follow-up. DESIGN: Pragmatic, multi-centre randomized trial. SETTING: Four Danish departments of gynaecology between May 2013 and May 2016. POPULATION: 156 women diagnosed with International Federation of Gynaecology and Obstetrics (FIGO) stage I low-intermediate risk endometrial carcinoma METHODS: Women allocated to the control group attended hospital-based follow-up consisting of regular out-patient visits for three years after primary treatment...
July 6, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29963597/a-study-on-cervical-cancer-screening-using-pap-smear-test-and-clinical-correlation
#12
Pushp Lata Sachan, Meenakshi Singh, Munna Lal Patel, Rekha Sachan
Objective: The objective of the study is to evaluate the use of the Pap smear screening method for detection of precancerous lesions. Methods: All women who visited the outpatient gynecology clinic of the Department of Obstetrics and Gynaecology at King Georges Medical University, Lucknow, UP, India, over 1 year for different clinical problems were recruited for the study. A total of 1650 women who were sexually active and over 21 years of age were enrolled in the study...
July 2018: Asia-Pacific Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29961649/serum-vitamin-d-levels-correlate-with-the-presence-and-histological-grading-of-colorectal-adenomas-in-peri-and-postmenopausal-women
#13
Pedro Marques da Costa, Inês Martins, Joaquim Neves, Helena Cortez-Pinto, José Velosa
BACKGROUND & AIMS: Vitamin D is known to modulate immune function and proliferation. Higher vitamin D [25(OH)D3 ] serum levels have been reported to have protective effects on adenoma detection and colorectal cancer (CRC) development and survival. METHODS: This retrospective cohort study included 315 peri and post-menopausal women submitted to opportunistic colorectal and osteoporosis screening at the gynaecology outpatient clinic of a tertiary medical centre between 2004 and 2015...
June 21, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29958236/esgo-survey-on-current-practice-in-the-management-of-cervical-cancer
#14
Lukas Dostalek, Elisabeth Åvall-Lundqvist, Carien L Creutzberg, Dina Kurdiani, Jordi Ponce, Iva Dostalkova, David Cibula
OBJECTIVE: The aim of this survey was to acquire an overview of the current management of cervical cancer with an emphasis on the early disease stages. MATERIALS AND METHODS: A hyperlink to the survey was sent to the European Society of Gynaecological Oncology Office database. The survey contained 6 groups of questions regarding the characteristics of respondents, pretreatment workup, management of the early stages of cervical cancer, adjuvant treatment, fertility-sparing treatment, and surveillance...
June 28, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29949936/glutathione-in-ovarian-cancer-a-double-edged-sword
#15
REVIEW
Sofia C Nunes, Jacinta Serpa
Glutathione (GSH) has several roles in a cell, such as a reactive oxygen species (ROS) scavenger, an intervenient in xenobiotics metabolism and a reservoir of cysteine. All of these activities are important in the maintenance of normal cells homeostasis but can also constitute an advantage for cancer cells, allowing disease progression and resistance to therapy. Ovarian cancer is the major cause of death from gynaecologic disease and the second most common gynaecologic malignancy worldwide. In over 50 years, the overall survival of patients diagnosed with epithelial ovarian cancer has not changed, regardless of the efforts concerning early detection, radical surgery and new therapeutic approaches...
June 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29947281/access-to-supportive-care-during-and-after-cancer-treatment-and-the-impact-of-socioeconomic-factors
#16
Lena Sharp, Bodil Westman, Anna Olofsson, Arja Leppänen, Roger Henriksson
BACKGROUND: Sweden's national cancer strategy points out several areas of cancer care that need improvements. Among them the need for supportive care resources to be accessible through the entire cancer trajectory and the reduction of socioeconomic inequalities. The aim of this study was to compare the patient-reported access to supportive care in the Stockholm-Gotland region between patients diagnosed in 2014 and 2016. The aim was also to describe how socioeconomic and other demographic factors impact access to supportive care...
June 27, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29944043/a-systematic-review-of-the-use-quality-and-effects-of-pelvic-examination-in-primary-care-for-the-detection-of-gynaecological-cancer
#17
P Williams, C M Bond, C Burton, P Murchie
AIM: This three part systematic review gathered all the current evidence on the use, quality and effects of pelvic examination (abdominal palpation, bimanual vaginal examination ± visualisation of the cervix) in primary care in diagnosing gynaecological cancer. Research questions • Do primary care practitioners perform pelvic examination during the assessment of symptoms, which are potentially indicative of gynaecological cancer? (RQ1) • What is the quality of pelvic examination performed in primary care, in terms of technical competence and interpretation of findings? (RQ2) • Is pelvic examination associated with the referral of patients with gynaecological cancer, and if so, in what way? (RQ3) Methods: PRISMA guidelines were followed...
July 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29944040/mirenas-against-malignancy-an-alternative-to-operative-management
#18
G Caldwell, K Ragupathy
BACKGROUND: Complex atypical hyperplasia is a recognised precursor to endometrial cancer, the most common gynaecological cancer of the Western World, with hysterectomy being the first line of management. With the increasing elderly population size and BMI, optimal surgical management can be challenging in a sub-set of patients. Levonorgestrol releasing IUS system (Mirena coil) has been identified as a treatment for those unsuitable for surgical management. AIMS: To assess the efficacy of Mirena coils in the treatment of endometrial cancers and complex atypical hyperplasia in our patient population...
July 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29943129/conservative-management-of-endometrial-cancer-a-survey-amongst-european-clinicians
#19
M La Russa, I Zapardiel, M J Halaska, K Zalewski, R Laky, P Dursun, D Lindquist, V Sukhin, S Polterauer, I Biliatis
OBJECTIVE: To investigate differences and similarities in the clinical approach of young clinicians managing women with endometrial cancer (EC) conservatively. METHODS: A web-based survey was carried out. A platform of the European Network of Young Gynaecological Oncologists (ENYGO) database was used. A 38-item multiple-choice questionnaire was used to evaluate current practice in fertility-sparing management of EC. The survey covered investigations, treatment options, follow-up and management of recurrence and future family planning...
August 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29938852/diurnal-profile-of-interstitial-glucose-following-dexamethasone-prophylaxis-for-chemotherapy-treatment-of-gynaecological-cancer
#20
M J Lyall, I Thethy, L Steven, M MacKean, F Nussey, M Sakala, T Rye, M W J Strachan, A R Dover
AIMS: Hyperglycaemia, a side-effect of acute glucocorticoid exposure, is associated with poor outcome in those undergoing chemotherapy. The incidence, risk factors and diurnal profile of glucocorticoid-induced glucose dysregulation in the context of chemotherapy treatment remain incompletely understood. METHODS: Blinded continuous interstitial glucose monitoring was performed on 16 women without diabetes for 24 h prior to and 5 days following carboplatin/paclitaxel chemotherapy combined with dexamethasone treatment for gynaecological cancer...
June 25, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
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