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gynaecological cancer

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https://www.readbyqxmd.com/read/29451900/the-arid1a-p53-and-%C3%A3-catenin-statuses-are-strong-prognosticators-in-clear-cell-and-endometrioid-carcinoma-of-the-ovary-and-the-endometrium
#1
Marlene Heckl, Elisa Schmoeckel, Linda Hertlein, Miriam Rottmann, Udo Jeschke, Doris Mayr
AIM: The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. MATERIALS AND METHODS: 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial carcinomas. RESULTS: Endometrioid ovarian carcinomas showed negative staining for ARID1A (a) and p21 (b), aberrant expression of p53 (c) and p16 (d) and ß-Catenin positive nuclear expression (e) respectively in 19% (a), 100% (b), 28...
2018: PloS One
https://www.readbyqxmd.com/read/29449189/adjuvant-chemoradiotherapy-versus-radiotherapy-alone-for-women-with-high-risk-endometrial-cancer-portec-3-final-results-of-an-international-open-label-multicentre-randomised-phase-3-trial
#2
Stephanie M de Boer, Melanie E Powell, Linda Mileshkin, Dionyssios Katsaros, Paul Bessette, Christine Haie-Meder, Petronella B Ottevanger, Jonathan A Ledermann, Pearly Khaw, Alessandro Colombo, Anthony Fyles, Marie-Helene Baron, Ina M Jürgenliemk-Schulz, Henry C Kitchener, Hans W Nijman, Godfrey Wilson, Susan Brooks, Silvestro Carinelli, Diane Provencher, Chantal Hanzen, Ludy C H W Lutgens, Vincent T H B M Smit, Naveena Singh, Viet Do, Romerai D'Amico, Remi A Nout, Amanda Feeney, Karen W Verhoeven-Adema, Hein Putter, Carien L Creutzberg
BACKGROUND: Although women with endometrial cancer generally have a favourable prognosis, those with high-risk disease features are at increased risk of recurrence. The PORTEC-3 trial was initiated to investigate the benefit of adjuvant chemotherapy during and after radiotherapy (chemoradiotherapy) versus pelvic radiotherapy alone for women with high-risk endometrial cancer. METHODS: PORTEC-3 was an open-label, international, randomised, phase 3 trial involving 103 centres in six clinical trials collaborating in the Gynaecological Cancer Intergroup...
February 12, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29441094/artificial-neural-network-based-gynaecological-image-guided-adaptive-brachytherapy-treatment-planning-correction-of-intra-fractional-organs-at-risk-dose-variation
#3
Ramin Jaberi, Zahra Siavashpour, Mahmoud Reza Aghamiri, Christian Kirisits, Reza Ghaderi
Purpose: Intra-fractional organs at risk (OARs) deformations can lead to dose variation during image-guided adaptive brachytherapy (IGABT). The aim of this study was to modify the final accepted brachytherapy treatment plan to dosimetrically compensate for these intra-fractional organs-applicators position variations and, at the same time, fulfilling the dosimetric criteria. Material and methods: Thirty patients with locally advanced cervical cancer, after external beam radiotherapy (EBRT) of 45-50 Gy over five to six weeks with concomitant weekly chemotherapy, and qualified for intracavitary high-dose-rate (HDR) brachytherapy with tandem-ovoid applicators were selected for this study...
December 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29434664/fertility-preservation-in-gynaecologic-cancers
#4
REVIEW
Francesca De Felice, Claudia Marchetti, Anna Di Pinto, Angela Musella, Innocenza Palaia, Maria Grazia Porpora, Ludovico Muzii, Vincenzo Tombolini, Pierluigi Benedetti Panici, Federica Tomao
Due to substantial improvement in the diagnosis and treatment of gynaecologic cancers, a better understanding of patient care needs to be revised. We reviewed the literature related to fertility preservation strategies in gynaecological cancer and discussed current general management approaches. New technical modalities and patients' own desire for motherhood should be integral and paramount in the clinical evaluation to significantly contribute to preserving fertility in those women diagnosed with gynaecologic cancers during the reproductive years...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29431861/non-steroidal-anti-inflammatory-agents-to-induce-regression-and-prevent-the-progression-of-cervical-intraepithelial-neoplasia
#5
REVIEW
Shannon M Grabosch, Osman M Shariff, C William Helm
BACKGROUND: This is an updated version of the original Cochrane review published in 2014, Issue 4. Cervical intraepithelial neoplasia (CIN) precedes the development of invasive carcinoma of the cervix. Current treatment of CIN is quite effective, but there is morbidity for the patient related to pain, bleeding, infection, cervical stenosis and premature birth in a subsequent pregnancy. Effective treatment with medications, rather than surgery, would be beneficial. OBJECTIVES: To evaluate the effectiveness and safety of non-steroidal anti-inflammatory agents (NSAIDs), including cyclooxygenase-2 (COX-2) inhibitors, to induce regression and prevent the progression of CIN...
February 12, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29430767/sexual-function-psychosocial-adjustment-to-illness-and-quality-of-life-among-chinese-gynaecological-cancer-survivors
#6
Ka Ming Chow, Winnie Kwok Wei So, Kai Chow Choi, Carmen Wing Han Chan
BACKGROUND: Disrupted sexual function is a prevalent and sustained side effect of gynaecological cancer and its related treatment. This problem may pose challenges to the survivors in the process of illness adjustment, leading to elevated psychological distress and impaired quality of life. However, care and interventions in this area have been neglected in most countries. OBJECTIVES: To investigate sexual function, psychosocial adjustment to illness and quality of life among Chinese gynaecological cancer survivors in Hong Kong, and to explore their associations...
February 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29426261/effect-of-blue-dye-guided-lymph-channel-ligation-on-the-surgical-morbidity-of-groin-lymphadenectomy-for-vulval-cancer-a-feasibility-study
#7
Rasiah Bharathan, Kavitha Madhuri, Andrew Fish, Peter Larsen-Disney, Jayanthan Chatterjee, Simon Butler-Manuel, Anil Tailor, Sean Kehoe
Inguinal lymphadenectomy has significant morbidity. Blue dye-guided lymph channel ligation is an effective technique for resolving lymphocele. This was a feasibility study in a preventative setting. Patients with vulval cancer requiring bilateral inguinal lymphadenectomy were recruited. After lymphadenectomy, patent blue V dye was injected and the severed lymph channels leaking blue dye, on the randomly-designated side were ligated. The median age was 72.5 years and the median body mass index was 25. The median lymph node harvest was 18...
February 9, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29402234/randomised-controlled-trial-protocol-grip-study-examining-the-effect-of-involvement-of-a-general-practitioner-and-home-care-oncology-nurse-after-a-cancer-diagnosis-on-patient-reported-outcomes-and-healthcare-utilization
#8
I A A Perfors, C W Helsper, E A Noteboom, E van der Wall, N J de Wit, A M May
BACKGROUND: Due to the ageing population and improving diagnostics and treatments, the number of cancer patients and cancer survivors is increasing. Policymakers, patients and professionals advocate a transfer of (part of) cancer care from the hospital environment to the primary care setting, as this could stimulate personalized and integrated care, increase cost-effectiveness and would better meet the patients' needs and expectations. The effects of structured active follow-up from primary care after cancer diagnosis have not been studied yet...
February 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29399968/utility-of-18f-fluorodeoxyglucose-positron-emission-tomography-in-the-differential-diagnosis-of-benign-and-malignant-gynaecological-tumours
#9
Hiroaki Takagi, Jinichi Sakamoto, Yasuhiro Osaka, Takeo Shibata, Satoko Fujita, Toshiyuki Sasagawa
INTRODUCTION: Positron emission tomography/computed tomography (PET/CT) involving 18F-fluorodeoxyglucose (FDG) is widely used for systemic cancer and recurrence diagnosis. However, the differential diagnosis of benign and malignant gynaecological tumours according to FDG accumulation is unclear. This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. METHODS: This study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F-FDG PET/CT...
February 5, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29397916/-fertility-preservation-contraception-and-menopause-hormone-therapy-in-women-treated-for-rare-ovarian-tumors-guidelines-from-the-french-national-network-dedicated-to-rare-gynaecological-cancer
#10
REVIEW
Christine Rousset-Jablonski, Fréderic Selle, Elodie Adda-Herzog, François Planchamp, Lise Selleret, Christophe Pomel, Nathalie Chabbert-Buffet, Emile Daraï, Patricia Pautier, Florence Trémollières, Frederic Guyon, Roman Rouzier, Valérie Laurence, Nicolas Chopin, Cécile Faure-Conter, Enrica Bentivegna, Marie-Cécile Vacher-Lavenu, Catherine Lhomme, Anne Floquet, Isabelle Treilleux, Fabrice Lecuru, Sébastien Gouy, Elsa Kalbacher, Catherine Genestie, Thibault de la Motte Rouge, Gwenael Ferron, Mojgan Devouassoux-Shisheboran, Jean-Emmanuel Kurtz, Moise Namer, Florence Joly, Eric Pujade-Lauraine, Michael Grynberg, Denis Querleu, Philippe Morice, Anne Gompel, Isabelle Ray-Coquard
INTRODUCTION: Rare ovarian tumors include complex borderline ovarian tumors, sex-cord tumors, germ cell tumors, and rare epithelial tumors. Indications and modalities of fertility preservation, infertility management and contraindications for hormonal contraception or menopause hormone therapy are frequent issues in clinical practice. A panel of experts from the French national network dedicated to rare gynaecological cancers, and of experts in reproductive medicine and gynaecology have worked on guidelines about fertility preservation, contraception and menopause hormone therapy in women treated for ovarian rare tumors...
February 1, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29388687/interventions-for-weight-reduction-in-obesity-to-improve-survival-in-women-with-endometrial-cancer
#11
REVIEW
Sarah Kitson, Neil Ryan, Michelle L MacKintosh, Richard Edmondson, James Mn Duffy, Emma J Crosbie
BACKGROUND: Diagnoses of endometrial cancer are increasing secondary to the rising prevalence of obesity. Obesity plays an important role in promoting the development of endometrial cancer, by inducing a state of unopposed oestrogen excess, insulin resistance and inflammation. It also affects treatment, increasing the risk of surgical complications and the complexity of radiotherapy planning, and may additionally impact on subsequent survival. Weight-loss interventions have been associated with improvements in breast and colorectal cancer-specific survival as well as a reduction in the risk of cardiovascular disease, a frequent cause of death in endometrial cancer survivors...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29385850/human-papilloma-virus-hpv-self-sampling-do-women-accept-it
#12
Nik Nairan Abdullah, Suzanna Daud, Seok Mui Wang, Zamalia Mahmud, Noor Kaslina Mohd Kornain, Waqar Al-Kubaisy
This study aims to determine the acceptability of Human Papilloma Virus (HPV) self-sampling and the factors associated with willingness to buy HPV self-sampling kit in the future. A total of 164 women aged 28-60 years old from Obstetrics & Gynaecology clinics at a teaching hospital performed HPV self-sampling using the Digene HC2 DNA collection kit. After samples were taken, the participants were given self-administered questionnaires. The majority of the participants were Malay (93.9%), had attained tertiary education (65...
January 31, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29384793/letter-to-the-editor-on-the-european-society-of-gynaecologic-oncology-quality-indicators-for-advanced-ovarian-cancer-surgery-by-querleu-et-al-int-j-gynecol-cancer-2016-26-1354-1363
#13
Sahar Salehi, Elisabet Hjerpe, Henrik Falconer
No abstract text is available yet for this article.
January 30, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29382323/prevalence-of-high-risk-hpv-genotypes-categorised-by-their-quadrivalent-and-nine-valent-hpv-vaccination-coverage-and-the-genotype-association-with-high-grade-lesions
#14
María Paz-Zulueta, Ledicia Álvarez-Paredes, Juan Carlos Rodríguez Díaz, Paula Parás-Bravo, Ma Encarnación Andrada Becerra, José María Rodríguez Ingelmo, María Montserrat Ruiz García, Joaquín Portilla, Miguel Santibañez
BACKGROUND: The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types (31, 33, 45, 52, and 58) remain significantly associated with high grade lesions. We aimed to determine the prevalence of high-risk HPV genotypes in unvaccinated subjects and the association of these genotypes with the incidence of high-grade lesions. We also assessed which, if either, of these two HPV vaccines could have prevented these cases...
January 30, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29381969/hpv-types-in-cervical-cancer-tissue-in-south-africa-a-head-to-head-comparison-by-mrna-and-dna-tests
#15
Amir Rad, Sveinung Wergeland Sørbye, Greta Dreyer, Siri Hovland, Bente Marie Falang, Melanie Louw, Finn Egil Skjeldestad
Accurate identification of human papillomavirus (HPV)-types in cervical cancer tissue may be important for tailoring tests for primary screening and types to be included in a vaccine. The aim of this study was to compare test-performance of a 45-type HPV deoxyribonucleic acid (DNA)-test with a 9-type HPV messenger ribonucleic acid (mRNA)-test in cervical cancer tissues.In a case-series design 188 women with diagnosed cervical cancer during the period January 2008 to July 1, 2011 at the Gynaecological Oncology Unit, University of Pretoria, South Africa were recruited to the study...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29379668/sleep-quality-of-endometrial-cancer-survivors-and-the-effect-of-treatments
#16
Tolgay Tuyan İlhan, Mustafa Gazi Uçar, Ayhan Gül, Türkan Saymaz İlhan, Güler Yavaş, Çetin Çelik
Objective: Sleep disorders affect 54.9% of gynaecologic cancer survivors. The effect of treatment methods on sleep quality is not clear. This study evaluated the sleep quality of survivors of endometrial cancer and compared the effects of different treatments on sleep quality. Materials and Methods: Patients were categorised as surgery (group 1), surgery + brachytherapy (BRT) (group 2), surgery + external beam radiation therapy (EBRT) (group 3), and surgery + EBRT + BRT + chemotherapy (group 4)...
December 2017: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29374722/surgical-outcomes-and-morbidity-after-radical-surgery-for-ovarian-cancer-in-aberdeen-royal-infirmary-the-northeast-of-scotland-gynaecologic-oncology-centre
#17
Emmanouil Kalampokas, Helena Young, Antonina Bednarek, Mohammad Habib, David E Parkin, Mahalakshmi Gurumurthy, Mary Cairns
BACKGROUND/AIM: Ovarian cancer (OC) has a high mortality rate and usually presents late in advanced stage, which poses challenges to management. Better understanding of the disease biology and application of radical surgery (RS) to achieve no visible residual tumor, alongside with chemotherapy, may lead to longer survival amongst these patients. Our purpose was to examine the demographic characteristics, surgical morbidity and outcomes of patients undergoing RS for OC. MATERIALS AND METHODS: A retrospective cohort study of women undertaking surgery for OC between February 2014 and September 2016 in Aberdeen Royal Infirmary...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29373116/uncommon-hereditary-gynaecological-tumour-syndromes-pathological-features-in-tumours-that-may-predict-risk-for-a-germline-mutation
#18
REVIEW
Karuna Garg, Anthony N Karnezis, Joseph T Rabban
The most common hereditary gynaecological tumour syndromes are hereditary breast and ovarian cancer syndrome and Lynch syndrome. However, pathologists also may encounter gynaecological tumours in women with rare hereditary syndromes. Many of these tumours exhibit distinctive gross and microscopic features that are associated with a risk for an inherited gene mutation. The sensitivity and specificity of these tumour pathology features for predicting an inherited mutation vary depending on the syndrome. By recognising these tumour features, pathologists may potentially contribute to the diagnosis of an unsuspected syndrome by recommending referral of the patient for formal risk assessment by genetic counselling...
January 17, 2018: Pathology
https://www.readbyqxmd.com/read/29371332/the-impact-of-27-hydroxycholesterol-on-endometrial-cancer-proliferation
#19
Douglas A Gibson, Frances Collins, Fiona L Cousins, Arantza Esnal Zufiaurre, Philippa T Saunders
Endometrial cancer (EC) is the most common gynaecological malignancy. Obesity is a major risk factor for EC and is associated with elevated cholesterol. 27-Hydroxycholesterol (27HC) is a cholesterol metabolite that functions as an endogenous agonist for Liver X Receptor (LXR) and a selective estrogen receptor modulator (SERM). Exposure to estrogenic ligands increases risk of developing EC however the impact of 27HC on EC is unknown. Samples of stage 1 EC (n=126) were collected from post-menopausal women undergoing hysterectomy...
January 25, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29359461/risk-factors-for-30-day-complications-after-cancer-surgery-in-geriatric-patients-a-secondary-analysis
#20
K Scholtz, C D Spies, R Mörgeli, R Eckardt, V von Dossow, S Braun, J Sehouli, M Bahra, C G Stief, K-D Wernecke, M Schmidt
BACKGROUND: The aim was to analyse the association between severity of complications up to 30 days after surgery and pre-operative nutritional and physical performance parameters. METHODS: The participants were a subsample of the previously published PERATECS study (ClinicalTrials.gov: NCT01278537) and included 517 onco-geriatric patients aged ≥ 65 years, undergoing thoracoabdominal, gynaecological, or urological surgery. Post-operative complications were classified according to the Clavien Classification System (CCS)...
January 22, 2018: Acta Anaesthesiologica Scandinavica
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