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gynaecological cancer

M Janda, S McGrath, A Obermair
Uterine cancer is the fifth most common cancer in women worldwide with an estimated 320,000 annual diagnoses. Its most common form, endometrioid adenocarcinoma of the endometrium (endometrial adenocarcinoma [EAC]), is thought to develop through excessive proliferation of endometrial glands, and then increasing steadily in incidence. The current standard treatment for EAC is hysterectomy, which is often curative. However, it may be unacceptably expensive for women with severe medical comorbidities, those who are at risk of intra- and postoperative adverse events and those who desire fertility...
August 31, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray, Yvonne L Hauck
BACKGROUND: Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with gynaecological cancer are not being met and provision of holistic care is a priority area for action. Knowledge on gynaecological cancer supportive care needs is limited, specifically comparison of needs and cancer gynaecological subtype. Our aim was to identify supportive care needs of Western Australian women experiencing gynaecological cancer, their satisfaction with help and explore associations between participant's demographic characteristics and identified needs...
September 21, 2018: BMC Cancer
Mekin Sezik, Erol Gurpinar, Nese Zayim
The aim was to perform a document content analysis of the subject titles in the undergraduate obstetrics and gynaecology (OG) curricula in Turkish medical schools regarding the National Core Curriculum revised in 2014 (NCC-2014). Two mini-focus group discussions with four voluntary OG faculty members in each session and one of the authors as the moderator were employed within a 1-week time frame to identify the primary (n = 36) and secondary (n = 15) NCC-2014 OG titles that were then compared for the alignment with the curricula of the various medical schools published on their website...
September 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Sterre T Paijens, Ninke Leffers, Toos Daemen, Wijnand Helfrich, H Marike Boezen, Ben J Cohlen, Cornelis Jm Melief, Marco de Bruyn, Hans W Nijman
BACKGROUND: This is the second update of the review first published in the Cochrane Library (2010, Issue 2) and later updated (2014, Issue 9).Despite advances in chemotherapy, the prognosis of ovarian cancer remains poor. Antigen-specific active immunotherapy aims to induce tumour antigen-specific anti-tumour immune responses as an alternative treatment for ovarian cancer. OBJECTIVES: Primary objective• To assess the clinical efficacy of antigen-specific active immunotherapy for the treatment of ovarian cancer as evaluated by tumour response measured by Response Evaluation Criteria In Solid Tumors (RECIST) and/or cancer antigen (CA)-125 levels, response to post-immunotherapy treatment, and survival differences◦ In addition, we recorded the numbers of observed antigen-specific humoral and cellular responsesSecondary objective• To establish which combinations of immunotherapeutic strategies with tumour antigens provide the best immunological and clinical results SEARCH METHODS: For the previous version of this review, we performed a systematic search of the Cochrane Central Register of Controlled Trials (CENTRAL; 2009, Issue 3), in the Cochrane Library, the Cochrane Gynaecological Cancer Group Specialised Register, MEDLINE and Embase databases, and clinicaltrials...
September 10, 2018: Cochrane Database of Systematic Reviews
C Badoual, J Pavie, M Ménard, S Pernot, B Cochand-Priollet, S Hurel, H Péré, A-S Bats
Given the recent increase in the number of human papillomavirus (HPV)-induced cancers in other locations than gynaecological, the number of patients with two cancers at distinct sites, and because of the lack of exhaustive data, we decided to create a multidisciplinary network around an HPV consultation at the Georges-Pompidou European Hospital (HEGP). This network aims to set up the best tools for detecting HPV-associated "multisite" precancerous lesions in order to determine the possible impact of dedicated care for this at-risk population...
October 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Naouel Tifaoui, Thierry Maudelonde, Jacques Combecal, Roselyne Vallo, Sylviane Doutre, Marie-Noëlle Didelot, Nicolas Nagot, Michel Segondy, Nathalie Boulle
BACKGROUND: With population ageing, post-menopausal women represent a new group to be considered in cervical cancer screening strategies, including the significance of High Risk (HR)-HPV detection. OBJECTIVES: A retrospective analysis was conducted in a cohort of 406 menopausal women attending routine gynaecological consultation at the Hospital of Montpellier (France). STUDY DESIGN: All women benefited from a cervical smear and HR-HPV detection using Hybrid Capture 2 (HC2) test...
August 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Michelle M Butler, Judith T Fullerton, Cheryl Aman
OBJECTIVE: To obtain consensus amongst midwifery experts globally about the essential competencies for basic midwifery practice. DESIGN: A modified Delphi approach, involving a three-round online survey. PARTICIPANTS: Midwifery leaders, educators and regulators in all ICM regions, along with representatives of organisations affiliated to ICM. METHODS: The research team worked closely with a Core Working Group and a Task Force...
August 17, 2018: Midwifery
Miyako Tsuchiya, Mariko Masujima, Miki Mori, Miyako Takahashi, Tomoyasu Kato, Shun-Ichi Ikeda, Chikako Shimizu, Takayuki Kinoshita, Sho Shiino, Makiko Suzuki
Objectives: To compare gynaecological and breast cancer patients in their information-seeking behaviours, usefulness of information sources and ongoing care needs after discharge to prevent the onset of lymphoedema. Methods: We conducted a consecutive cross-sectional survey in an oncology hospital. Adult patients with stage I, II or III gynaecological or breast cancer who had undergone lymph node dissection and had not been diagnosed with lymphoedema were eligible for inclusion...
September 6, 2018: Japanese Journal of Clinical Oncology
Aleksandra Sobota, Gozde Ozakinci
BACKGROUND: Although there is a recognition of the importance of fertility to young women with cancer, we do not know who is at risk of distress related to fertility issues following diagnosis. We investigated the determinants of fertility-related distress adopting a cross-cultural perspective and using the Common Sense Model (CSM). We chose the CSM as a theoretical framework as it allows to explore how individuals conceptualise illness within the socio-cultural context. METHODS: British and Polish women with breast or gynaecological cancer were recruited through outpatient clinics or online outlets and completed a questionnaire...
September 6, 2018: BMC Cancer
Osman Aşıcıoğlu, Kemal Gungorduk, Aykut Ozdemir, Özgü Güngördük, Mehmet Gokçü, Levent Yaşar, Muzaffer Sancı
The purpose of this study was to develop a model predicting the probability of pelvic-paraaortic node metastases in high-risk endometrial cancer patients. This trial included 41 high-risk endometrial cancer patients. All of the patients underwent an 18-FDG PET-CT followed by surgical staging, including a pelvic and paraaortic lymphadenectomy. We developed a useful scoring system combining weighted risk factors derived from a regression model: (3 × presence PET-CT involvement) + (3 × PET-CT maximum standardised uptake value ≥20) + (2 × diabetes comorbidity) + (1 × age ≥60 years) + (1 × body mass index ≥30)...
September 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Alicia Ehlers, Chandra Rekha Makanjee
Introduction: Performing brachytherapy on female patients with gynaecological cancer is a sensitive procedure, apart from it being an intricate investigation. The aim of this study: establishing gynaecological cancer patients' expectations, experiences and understandings of the high dose-rate brachytherapy treatment procedure. Exploring these patients' life-worlds provides further insights into improving their preparedness and experiences. Methods: A qualitative research design with a descriptive phenomenological research approach was used...
2018: Pan African Medical Journal
Jing Zhang, Wenxue Liu, Fangqian Shen, Xiaoling Ma, Xiaorui Liu, Fuju Tian, Weihong Zeng, Xiaowei Xi, Yi Lin
Among the gynaecological cancers, epithelial ovarian cancer (EOC) has the highest lethality because of the high incidence of tumour progression and metastasis. Exploration of the detailed mechanisms underlying EOC metastasis and the identification of crucial targets is important to better estimate the prognosis and improve the treatment of this disease. The present study aimed to identify the role of miR-520h in the prognosis of patients with EOC, and the mechanisms of its involvement in EOC progression. We showed that miR-520h was upregulated in 116 patients with EOC, especially in those with advanced-stage disease, and high miR-520h expression predicted poor outcome...
August 29, 2018: Cell Death & Disease
Gonda Fj Konings, Niina Saarinen, Bert Delvoux, Loes Kooreman, Pasi Koskimies, Camilla Krakstad, Kristine E Fasmer, Ingfrid S Haldorsen, Amina Zaffagnini, Merja R Häkkinen, Seppo Auriola, Ludwig Dubois, Natasja Lieuwes, Frank Verhaegen, Lotte Ejr Schyns, Roy Fpm Kruitwagen, Sofia Xanthoulea, Andrea Romano
Endometrial cancer (EC) is the most common gynaecological malignancy in Western society and the majority of cases are estrogen dependent. While endocrine drugs proved to be of insufficient therapeutic value in the past, recent clinical research shows promising results by using combinational regimens and pre-clinical studies and identified potential novel endocrine targets. Relevant pre-clinical models can accelerate research in this area. In the present study we describe an orthotopic and estrogen dependent xenograft mouse model of EC...
August 28, 2018: International Journal of Molecular Sciences
Mário Bruno Santos, Rita Félix Soares, Filipe Basto
Women undergoing pelvic lymphadenectomy and radiation therapy for gynaecological cancer are prone to acute and often recurrent cellulitis as a consequence of compromised lymphatic circulation. Vaginal intercourse can trigger the infection, a condition named streptococcal sex syndrome (SSS). We report a 63-year old female patient with a history of pelvic lymphadenectomy and radiation therapy for gynaecological cancer. She presented to the obstetrics/gynaecology department for vaginal haemorrhage during sexual intercourse the day before...
November 2018: Gynecologic Oncology Reports
Frank Daniel Martos-Benítez, Anarelys Gutiérrez-Noyola, Andrés Soto García, Iraida González-Martínez, Ilionanys Betancour-Plaza
BACKGROUND: Some factors can act on nutritional status of patients operated for a gastrointestinal cancer. A timely and appropriate nutritional intervention could have a positive effect on postoperative outcomes. AIM: To determine the effect of a program of intestinal rehabilitation and early postoperative enteral nutrition on complications and clinical outcomes of patients underwent gastrointestinal surgery for cancer. METHODS: This is a prospective study of 465 patients underwent gastrointestinal surgery for cancer consecutively admitted in an oncological intensive care unit...
August 16, 2018: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Ida Hovdenak Jakobsen, Mette Moustgaard Jeppesen, Sébastien Simard, Henriette Vind Thaysen, Søren Laurberg, Therese Juul
PURPOSE: The Fear of Cancer Recurrence Inventory (FCRI) is a multidimensional measure for fear of cancer recurrence (FCR). The aim of this study was to assess the psychometric properties of the translated Danish version of the FCRI in a population of colorectal cancer patients. METHODS: The English version of the FCRI was forward-backward translated into Danish and pilot tested in a gynaecological cancer population. The psychometric properties of the FCRI were assessed in terms of responsiveness, test-retest reliability and discriminative and convergent validity in a population of colorectal cancer patients by asking them to complete questionnaires at three time points during follow-up...
August 20, 2018: Journal of Cancer Survivorship: Research and Practice
F Lucia, U Schick, O Pradier, S Espenel, R de Crevoisier, C Chargari
Intensity-modulated radiation therapy reduces the dose to organs at risk in patients treated for gynecological malignancies. Given the steep dose gradients around the planning target volume, internal movement of organs during treatment may cause a planning target volume underdosage and organs at risk overdosage in case of systematic error. It is therefore important to take into account the movement of the pelvic organs and to investigate potential solutions provided by image-guided radiotherapy. A review of the literature was carried out using the following databases: Medline, Embase, Cochrane Library, Web of Science, Cinahl and Pubmed...
August 17, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Harshitha Pandey, Shyamala Guruvare, Rajagopal Kadavigere, Chythra R Rao
OBJECTIVE: The study was conducted to find the utility of three dimensional (3-D) ultrasound and Doppler sonography in differentiating benign and malignant endometrial lesions and to ascertain the association of sonology parameters with type, grade and stage of endometrial cancer. MATERIALS AND METHODS: Women attending the gynaecology department of a tertiary care hospital, with a provisional diagnosis of carcinoma endometrium were subjected to three dimensional power Doppler ultrasound evaluation and assessment of vascular patterns...
August 2018: Taiwanese Journal of Obstetrics & Gynecology
Haihong Liao, Yunfei Pan, Yuefen Pan, Junjun Shen, Quan Qi, Liping Zhong, Wenshu Han, Qi Wang, Yizhen Jiang
An increasing number of studies have reported that microRNAs (miRNAs) are dysregulated in cervical cancer and serve critical roles in cervical oncogenesis and progression. Therefore, identifying the aberrantly expressed miRNAs implicated in the formation and progression of cervical cancer may provide key clues for the development of effective therapeutic targets in treating patients with this type of malignancy. In the present study, miRNA‑874 (miR‑874) was downregulated in cervical cancer tissues and cell lines, and this downregulation was associated with International Federation of Gynaecology and Obstetrics stage and lymph node metastasis...
October 2018: Oncology Reports
Wieke W Kremer, Marjolein Van Zummeren, Putri W Novianti, Karin L Richter, Wina Verlaat, Peter Jf Snijders, Daniëlle Am Heideman, Renske Dm Steenbergen, Greta Dreyer, Chris Jlm Meijer
INTRODUCTION: To evaluate the performance of hypermethylation analysis of ASCL1, LHX8 and ST6GALNAC5 in physician-taken cervical scrapes for detection of cervical cancer and cervical intraepithelial neoplasia (CIN) grade 3 in women living with HIV (WLHIV) in South Africa. METHODS: Samples from a prospective observational cohort study were used for these analyses. Two cohorts were included: a cohort of WLHIV who were invited for cervical screening (n = 321) and a gynaecologic outpatient cohort of women referred for evaluation of abnormal cytology or biopsy proven cervical cancer (n = 108, 60% HIV seropositive)...
August 2018: Journal of the International AIDS Society
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