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Cancer AND FDG Accumulation

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https://www.readbyqxmd.com/read/29218614/18f-fluorodeoxyglucose-specimen-positron-emission-mammography-delineates-tumour-extension-in-breast-conserving-surgery-preliminary-results
#1
Gou Watanabe, M Itoh, X Duan, H Watabe, N Mori, H Tada, A Suzuki, M Miyashita, N Ohuchi, T Ishida
OBJECTIVES: We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. METHODS: Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining 18F-FDG accumulation were scanned by high-resolution PEM...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29217733/sex-as-a-biological-variable-in-preclinical-imaging-research-initial-observations-with-18f-fluorothymidine
#2
Szeman Ruby Chan, Kelley Salem, Justin Jeffery, Ginny L Powers, Yongjun Yan, Kooresh I Shoghi, Aparna M Mahajan, Amy M Fowler
The study objective was to investigate whether sex influences 3'-deoxy-3'-[18F]fluorothymidine (18F-FLT) uptake and tissue distribution in mouse models of cancer. Methods:18F-FLT biodistribution was measured in three strains of male and female mice (129S6/SvEv, athymic nude, and BALB/c). 18F-Fluoro-2-deoxy-2-D-glucose (18F-FDG) biodistribution was performed for comparison. 18F-FLT uptake was also measured in female 129S6/SvEv mice bearing estrogen-dependent SSM3 mouse mammary tumors, male athymic nude mice bearing androgen-dependent CWR22 prostate cancer xenografts, and male and female athymic nude mice bearing estrogen-independent MDA-MB-231 human breast cancer xenografts...
December 7, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29145106/metachronous-mediastinal-lymph-node-metastasis-from-ascending-colon-cancer-a-case-report-and-literature-review
#3
Kosuke Toda, Kenji Kawada, Yoshiharu Sakai, Hiroshi Izumi
INTRODUCTION: Metachronous mediastinal lymph node metastasis without pulmonary metastasis is extremely rare in colorectal cancer, which makes the clinical diagnosis difficult and treatment strategy unclear. PRSENTATION OF CASE: A case was a 59-year-old man, who had undergone right hemicolectomy for ascending colon cancer 2 years and 8 months previously, presented with enlarged mediastinal lymph nodes. (18)F-fluorodeoxyglucose (FDG) positron emission tomography revealed FDG was accumulated only into the mediastinal lymph nodes...
November 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29142019/molecular-imaging-of-glut1-and-glut5-in-breast-cancer-a-multitracer-pet-imaging-study-in-mice
#4
Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West, Frank Wuest
Use of [18F]FDG-PET in clinical breast cancer (BC) imaging is limited mainly due to insufficient expression levels of GLUT1 in up to 50% of all patients. Fructose-specific facilitative hexose transporter GLUT5 represents an alternative biomarker for PET imaging of hexose metabolism in BC. The goal of the present study was to compare uptake characteristics of selected hexose-based PET radiotracers in murine BC model EMT6. Uptake of 1-deoxy-1-[18F]fluoro-D-fructose (1-[18F]FDF), 6-deoxy-6-[18F]fluoro-D-fructose (6-[18F]FDF), 1-deoxy-1-[18F]fluoro-2,5-anhydro-mannitol (1-[18F]FDAM), 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) and 6-deoxy-6-[18F]fluoro-D-glucose (6-[18F]FDG) was studied in EMT6 cells, tumors and muscle and correlated to GLUT1 and GLUT5 expression levels...
November 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29130979/18f-famt-pet-is-useful-to-distinguish-between-specific-uptake-and-nonspecific-uptake-compared-to-18f-flourodeoxyglucose-position-emission-tomography-in-esophageal-cancer-patients
#5
Makoto Sohda, Tatsuya Miyazaki, Hiroaki Honjyo, Keigo Hara, Daigo Ozawa, Makoto Sakai, Takehiko Yokobori, Tetsuya Higuchi, Yoshito Tsushima, Hiroyuki Kuwano
BACKGROUND: L-[3-18F]-α-methyltyrosine (18F-FAMT) solely accumulates in tumor cells via an amino acid transport system. This selective uptake pattern results in a very high tumor-to-background ratio, enabling clear delineation of the tumor. The purpose of the present study was to assess the significance of 18F-FAMT PET, which shows little nonspecific uptake compared to 18F-flourodeoxyglucose position emission tomography (FDG PET) in esophageal cancer patients. METHODOLOGY: PET-CT studies with 18F-FAMT and 18F-FDG were performed as part of pretreatment work-up in 82 patients with histologically confirmed esophageal cancer...
November 2, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29109795/the-use-of-pet-imaging-for-prognostic-integrin-%C3%AE-2%C3%AE-1-phenotyping-to-detect-non-small-cell-lung-cancer-and-monitor-drug-resistance-responses
#6
Chiun-Wei Huang, Wen-Chuan Hsieh, Shih-Ting Hsu, Yi-Wen Lin, Yi-Hsiu Chung, Wen-Chi Chang, Han Chiu, Yun Han Lin, Chung-Pu Wu, Tzu-Chen Yen, Feng-Ting Huang
PURPOSE: Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting (68)Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used (18)F-FDG PET tracer to see if (68)Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer...
2017: Theranostics
https://www.readbyqxmd.com/read/29098026/mismatched-intratumoral-distribution-of-18-f-fluorodeoxyglucose-and-3-deoxy-3-18-f-fluorothymidine-in-patients-with-lung-cancer
#7
Xiangcheng Wang, Yulin He, Weina Zhou, Xia Bai, Yiwei Wu, Xuemei Wang, Xiao-Feng Li
In a mouse model of human lung cancer, intratumoral distribution between 3'-deoxy-3'-[(18)F] fluorothymidine ((18)F-FLT) and [(18)F] fluorodeoxyglucose ((18)F-FDG) was mutually exclusive. (18)F-FLT primarily accumulated in proliferating cancer cells, whereas (18)F-FDG accumulated in hypoxic cancer cells. The aim of the present study was to evaluate these preclinical findings in patients with lung cancer. A total of 55 patients with solitary pulmonary lesion were included in the present study. Patients underwent (18)F-FLT positron emission tomography-computed tomography (PET/CT) and (18)F-FDG PET/CT scan with a 3-day interval...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29061130/-18-f-fdg-pet-ct-helps-differentiate-autoimmune-pancreatitis-from-pancreatic-cancer
#8
Jian Zhang, Guorong Jia, Changjing Zuo, Ningyang Jia, Hui Wang
BACKGROUND: (18)F-FDG PET/CT could satisfactorily show pancreatic and extra-pancreatic lesions in AIP, which can be mistaken for pancreatic cancer (PC). This study aimed to identify (18)F-FDG PET/CT findings that might differentiate AIP from PC. METHODS: FDG-PET/CT findings of 26 AIP and 40 PC patients were reviewed. Pancreatic and extra-pancreatic lesions related findings, including maximum standardized uptake values (SUVmax) and patterns of FDG uptake, were identified and compared...
October 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29051991/radiation-induced-liver-injury-mimicking-liver-metastases-on-fdg-pet-ct-after-chemoradiotherapy-for-esophageal-cancer-a%C3%A2-retrospective-study-and-literature-review
#9
Francine E M Voncken, Berthe M P Aleman, Jolanda M van Dieren, Cecile Grootscholten, Ferry Lalezari, Johanna W van Sandick, Jeffrey D Steinberg, Erik Vegt
BACKGROUND: For esophageal cancer patients treated with neoadjuvant chemoradiotherapy (nCRT), restaging using F‑18-fluorodeoxyglucose (FDG) positron emission tomography computed tomography (PET-CT) following nCRT can detect interval metastases, including liver metastases, in almost 10% of patients. However, in clinical practice, focal FDG liver uptake, unrelated to liver metastases, is observed after chemoradiotherapy. This radiation-induced liver injury (RILI) can potentially lead to overstaging...
October 19, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29025377/18f-fdg-pet-ct-in-breast-cancer-evidence-based-recommendations-in-initial-staging
#10
REVIEW
Ana Paula Caresia Aroztegui, Ana María García Vicente, Soledad Alvarez Ruiz, Roberto Carlos Delgado Bolton, Javier Orcajo Rincon, Jose Ramon Garcia Garzon, Maria de Arcocha Torres, Maria Jose Garcia-Velloso
Current guidelines do not systematically recommend 18F-FDG PET/CT for breast cancer staging; and the recommendations and level of evidence supporting its use in different groups of patients vary among guidelines. This review summarizes the evidence about the role of 18F-FDG PET/CT in breast cancer staging and the therapeutic and prognostic impact accumulated in the last decade. Other related aspects, such as the association of metabolic information with biology and prognosis are considered and evidence-based recommendations for the use of 18F-FDG PET/CT in breast cancer staging are offered...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29019325/ambiguity-of-whole-body-pet-ct-scans-in-diagnosis-of-co-existing-tuberculosis-and-malignancy-is-histopathological-confirmation-mandatory
#11
Prekshi Chaudhary, Sweety Gupta, Nitin Leekha, Ravi S Rajendra, Shiv S Mishra, Vandana Arora, Sudarsan De, Sandeep Agarwal
INTRODUCTION: Whole body PET CT is an important investigation tool in malignancy patients and helps in ascertaining the metabolic activity and exact stage of the disease. However, like any other investigation, false positive results do exist and certain diseases other than cancer may show increased uptake. Hence, a careful evaluation of PET CT and clinical correlation in malignancy patients is a must to accomplish the suitable treatment. METHODS: In this retrospective observational study, seven cases of cancer with concomitant tuberculosis were included...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28915583/n-acetylcysteine-breaks-resistance-to-trastuzumab-caused-by-muc4-overexpression-in-human-her2-positive-bc-bearing-nude-mice-monitored-by-89-zr-trastuzumab-and-18-f-fdg-pet-imaging
#12
Zéna Wimana, Geraldine Gebhart, Thomas Guiot, Bruno Vanderlinden, Denis Larsimont, Gilles Doumont, Gaetan Van Simaeys, Serge Goldman, Patrick Flamen, Ghanem Ghanem
Trastuzumab remains an important drug in the management of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer (BC). Several studies reported resistance mechanisms to trastuzumab, including impaired HER2-accessibility caused by mucin 4 (MUC4). Previously, we demonstrated an increase of Zirconium-89-radiolabeled-trastuzumab ((89)Zr-Trastuzumab) accumulation when MUC4-overexpressing BC-cells were challenged with the mucolytic drug N-Acetylcysteine (NAC). Hereby, using the same approach we investigated whether tumor exposure to NAC would also enhance trastuzumab-efficacy...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#13
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28875691/construction-and-evaluation-of-a-targeted-hyaluronic-acid-nanoparticle-photosensitizer-complex-for-cancer-photodynamic-therapy
#14
Shi Gao, Jingjing Wang, Rui Tian, Guohao Wang, Liwen Zhang, Yesen Li, Lu Li, Qingjie Ma, Lei Zhu
Photodynamic therapy (PDT) is a novel treatment modality that is under intensive preclinical investigations for a variety of diseases, including cancer. Despite extensive studies in this area, selective and effective photodynamic agents that can specifically accumulate in tumors to reach a therapeutic concentration are limited. Although recent attempts have produced photosensitizers (PSs) complexed with various nanomaterials, the tedious preparation steps and poor tumor efficiency of therapy hamper their utilization...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28875472/evaluation-of-novel-64-cu-labeled-theranostic-gadolinium-based-nanoprobes-in-hepg2-tumor-bearing-nude-mice
#15
Pengcheng Hu, Dengfeng Cheng, Tao Huang, Anna B Banizs, Jie Xiao, Guobing Liu, Quan Chen, Yuenan Wang, Jiang He, Hongcheng Shi
Radiation therapy of liver cancer is limited by low tolerance of the liver to radiation. Radiosensitizers can effectively reduce the required radiation dose. AGuIX nanoparticles are small, multifunctional gadolinium-based nanoparticles that can carry radioisotopes or fluorescent markers for single-photon emission computed tomography (SPECT), positron emission tomography (PET), fluorescence imaging, and even multimodality imaging. In addition, due to the high atomic number of gadolinium, it can also serve as a tumor radiation sensitizer...
September 6, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28819951/metformin-a-new-old-drug
#16
Marta Patrycja Wróbel, Bogdan Marek, Dariusz Kajdaniuk, Dominika Rokicka, Aleksandra Szymborska-Kajanek, Krzysztof Strojek
For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. It is then combined with a sulfony-lurea, an incretin, flozin, or insulin, irrespective of the number of insulin injections per day. Besides its properties used in the treatment of diabetes, metformin has been treated for some time as a drug of a so-called pleiotropic activity, as each year brings new reports about its favourable effect in different conditions...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28808756/relationship-between-18-f-fluorodeoxyglucose-accumulation-and-the-braf-v600e-mutation-in-papillary-thyroid-cancer
#17
Jae Won Chang, Ki Wan Park, Jae Hyung Heo, Seung-Nam Jung, Lihua Liu, Sung Min Kim, In Sun Kwon, Bon Seok Koo
BACKGROUND: To determine whether (18)F-fluoro-2-deoxyglucose ((18)F-FDG)-PET/CT is useful for predicting the BRAF (V600E) mutation status of a primary papillary thyroid carcinoma (PTC). METHODS: A retrospective analysis was performed in 108 patients who underwent (18)F-FDG positron emission tomography-computed tomography (PET/CT) for staging before thyroidectomy and BRAF analysis in biopsy-confirmed PTC. The maximum standardized uptake value (SUVmax) of the primary tumor was calculated according to FDG accumulation...
August 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28795272/pet-imaging-on-dynamic-metabolic-changes-after-combination-therapy-of-paclitaxel-and-the-traditional-chinese-medicine-in-breast-cancer-bearing-mice
#18
Yao Chen, Ling Wang, Hao Liu, Fahuan Song, Caiyun Xu, Kai Zhang, Qing Chen, Shuang Wu, Yunqi Zhu, Ying Dong, Min Zhou, Hong Zhang, Mei Tian
PURPOSE: The aim of the study was to non-invasively evaluate the anticancer activity of a traditional Chinese medicine-Huaier, combined with paclitaxel (PTX) in breast cancer bearing mice by detecting dynamic metabolic changes with positron emission tomography (PET). PROCEDURES: Balb/c nude mice were randomly divided into one of the four groups: Huaier, PTX, PTX + Huaier, or the control. PET imaging with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) was performed to monitor the metabolic changes in BT474 (luminal B) and MDA-MB-231 (triple-negative) breast cancer xenografts...
August 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28774899/-89-zr-anti-%C3%AE-h2ax-tat-but-not-18-f-fdg-allows-early-monitoring-of-response-to-chemotherapy-in-a-mouse-model-of-pancreatic-ductal-adenocarcinoma
#19
James C Knight, Michael J Mosley, Luisa Contreras Bravo, Veerle Kersemans, P Danny Allen, Somnath Mukherjee, Eric O'Neill, Bart Cornelissen
Purpose: Late-stage, unresectable pancreatic ductal adenocarcinoma (PDAC) is largely resistant to chemotherapy and consequently has a very poor 5-year survival rate of <5%. The ability to assess the efficacy of a treatment soon after its initiation would enable rapid switching to potentially more effective therapies if the current treatment is found to be futile. We have evaluated the ability of the PET imaging agent, (89)Zr-anti-γH2AX-TAT, to monitor DNA damage in response to fluorouracil (5-FU), gemcitabine, or capecitabine treatment in a mouse model of pancreatic cancer...
August 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28759520/enhanced-application-of-18f-fdg-pet-ct-in-bladder-cancer-by-adding-early-dynamic-acquisition-to-a-standard-delayed-pet-protocol
#20
Hai-Jeon Yoon, Jang Yoo, Yemi Kim, Dong Hyeon Lee, Bom Sahn Kim
PURPOSE: We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. METHODS: Fifty-two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement...
October 2017: Clinical Nuclear Medicine
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