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Cancer AND FDG Accumulation

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https://www.readbyqxmd.com/read/28819951/metformin-a-new-old-drug
#1
Marta Patrycja Wróbel, Bogdan Marek, Dariusz Kajdaniuk, Dominika Rokicka, Aleksandra Szymborska-Kajanek, Krzysztof Strojek
For many years metformin has been the gold standard in the treatment of type 2 diabetes. According to recommendations of the most important diabetes associations, this is the first-choice drug for use as monotherapy in patients with newly diagnosed type 2 diabetes. Metformin is also recommended in combined treatment when monotherapy is no longer effective. It is then combined with a sulfony-lurea, an incretin, flozin, or insulin, irrespective of the number of insulin injections per day. Besides its properties used in the treatment of diabetes, metformin has been treated for some time as a drug of a so-called pleiotropic activity, as each year brings new reports about its favourable effect in different conditions...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28808756/relationship-between-18-f-fluorodeoxyglucose-accumulation-and-the-braf-v600e-mutation-in-papillary-thyroid-cancer
#2
Jae Won Chang, Ki Wan Park, Jae Hyung Heo, Seung-Nam Jung, Lihua Liu, Sung Min Kim, In Sun Kwon, Bon Seok Koo
BACKGROUND: To determine whether (18)F-fluoro-2-deoxyglucose ((18)F-FDG)-PET/CT is useful for predicting the BRAF (V600E) mutation status of a primary papillary thyroid carcinoma (PTC). METHODS: A retrospective analysis was performed in 108 patients who underwent (18)F-FDG positron emission tomography-computed tomography (PET/CT) for staging before thyroidectomy and BRAF analysis in biopsy-confirmed PTC. The maximum standardized uptake value (SUVmax) of the primary tumor was calculated according to FDG accumulation...
August 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28795272/pet-imaging-on-dynamic-metabolic-changes-after-combination-therapy-of-paclitaxel-and-the-traditional-chinese-medicine-in-breast-cancer-bearing-mice
#3
Yao Chen, Ling Wang, Hao Liu, Fahuan Song, Caiyun Xu, Kai Zhang, Qing Chen, Shuang Wu, Yunqi Zhu, Ying Dong, Min Zhou, Hong Zhang, Mei Tian
PURPOSE: The aim of the study was to non-invasively evaluate the anticancer activity of a traditional Chinese medicine-Huaier, combined with paclitaxel (PTX) in breast cancer bearing mice by detecting dynamic metabolic changes with positron emission tomography (PET). PROCEDURES: Balb/c nude mice were randomly divided into one of the four groups: Huaier, PTX, PTX + Huaier, or the control. PET imaging with 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) was performed to monitor the metabolic changes in BT474 (luminal B) and MDA-MB-231 (triple-negative) breast cancer xenografts...
August 9, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28774899/89zr-anti-%C3%AE-h2ax-tat-but-not-18f-fdg-allows-early-monitoring-of-response-to-chemotherapy-in-a-mouse-model-of-pancreatic-ductal-adenocarcinoma
#4
James C Knight, Michael J Mosley, Luisa Contreras Bravo, Veerle Kersemans, Philip D Allen, Somnath Mukherjee, Eric O'Neill, Bart Cornelissen
Purpose: Late-stage, unresectable pancreatic ductal adenocarcinoma (PDAC) is largely resistant to chemotherapy and consequently has a very poor 5-year survival rate of < 5%. The ability to assess the efficacy of a treatment soon after its initiation would enable rapid switching to potentially more effective therapies if the current treatment is found to be futile. We have evaluated the ability of the PET imaging agent, (89)Zr-anti-γH2AX-TAT, to monitor DNA damage in response to fluouracil (5-FU), gemcitabine, or capecitabine treatment in a mouse model of pancreatic cancer...
August 3, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28759520/enhanced-application-of-18f-fdg-pet-ct-in-bladder-cancer-by-adding-early-dynamic-acquisition-to-a-standard-delayed-pet-protocol
#5
Hai-Jeon Yoon, Jang Yoo, Yemi Kim, Dong Hyeon Lee, Bom Sahn Kim
PURPOSE: We investigated the value of early dynamic (ED) PET for the detection and characterization of bladder cancer. METHODS: Fifty-two bladder cancer patients were prospectively enrolled. The study protocol was composed of ED, whole-body (WB, 60 minutes after injection), and additional delayed (AD, 120 minutes after injection) PET acquisition. Early dynamic PET was acquired for 10 minutes and reconstructed as 5 frames at 2-minute intervals. A focal radiotracer accumulation confined to the bladder wall was considered as PET positive and referred for further quantitative measurement...
July 29, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28656060/pet-tracer-18-f-fluciclovine-can-detect-histologically-proven-bone-metastatic-lesions-a-preclinical-study-in-rat-osteolytic-and-osteoblastic-bone-metastasis-models
#6
Shuntaro Oka, Masaru Kanagawa, Yoshihiro Doi, David M Schuster, Mark M Goodman, Hirokatsu Yoshimura
(18)F-Fluciclovine (trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid; anti-(18)F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer). The most frequent metastatic organ of these cancers is bone. Fluciclovine-PET can visualize bony lesions in clinical practice; however, such lesions have not been described histologically. Methods: We investigated the potential of (14)C-fluciclovine in aiding the visualization of osteolytic and osteoblastic bone metastases (with histological analyses), compared with (3)H-2-deoxy-2-fluoro-D-glucose ((3)H-FDG), (3)H-choline chloride ((3)H-choline), and (99m)Tc-hydroxymethylene diphosphonate ((99m)Tc-HMDP) by using triple-tracer autoradiography in rat breast cancer osteolytic (on day 12 ± 1 postinjection of MRMT-1) and prostate cancer osteoblastic (on day 20 ± 3 postinjection of AT6...
2017: Theranostics
https://www.readbyqxmd.com/read/28625410/sialadenoma-papilliferum-in-the-buccal-mucosa-detected-on-18-f-fluorodeoxyglucose-positron-emission-tomography
#7
S Miyamoto, T Ogawa, D Chikazu
An incidental discovery of an accumulation of (18)F-fluorodeoxyglucose (FDG) in the oral cavity of patients with malignant tumours on FDG positron emission tomography (PET) can pose a problem regarding the differential diagnosis of metastatic lesions. Large accumulations can often be found even when tumours in the salivary or thyroid gland are benign, so FDG-PET is limited in its ability to differentiate between benign and malignant disease. This report describes a rare case of sialadenoma papilliferum in the buccal mucosa that was discovered incidentally on FDG-PET in a patient with multiple metastases to bone after an operation for rectal cancer...
June 16, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28619735/the-evolving-role-of-succinate-in-tumor-metabolism-an-18-f-fdg-based-study
#8
Philippe Garrigue, Aurore Bodin-Hullin, Laure Balasse, Samantha Fernandez, Wassim Essamet, Françoise Dignat-George, Karel Pacak, Benjamin Guillet, David Taieb
Objective: In recent years, inherited and acquired mutations in the TCA cycle enzymes have been reported in diverse cancers. Pheochromocytomas and paragangliomas (PPGLs) often exhibit dysregulation of glucose metabolism which is also driven by mutations in genes encoding the TCA cycle enzymes or by activation of hypoxia signaling. PPGLs associated with succinate dehydrogenase (SDH) deficiency are characterized by high (18)F-fluorodeoxyglucose ([(18)F]-FDG) avidity. This association is currently only partially explained...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28553186/liver-metastasis-of-lung-cancer-detected-with-similar-uptake-pattern-on-bone-scintigraphy-and-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-what-s-the-pathophysiologic-mechanism
#9
Funda Üstün, Salim Aksoy, Burcu Dirlik Serim, Gülay Durmuş Altun
Bone scintigraphy with (99m)Tc diphosphonates may exhibit extraosseous lesions in addition to metastatic lesions. Multiple factors can affect extraosseous (99m)Tc methylene diphosphonate (MDP) uptake. Similar uptake pattern of (99m)Tc MDP and fluorine-18 fluorodeoxyglucose ((18)F FDG) in hepatic metastasis was not already notified. In our case, initial tumor necrosis and subsequent intracellular calcification resulted in similar (99m)Tc MDP and (18)F FDG accumulation in the metastatic area.
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28522155/fibroelastic-pseudotumour-elastofibroma-dorsi-detected-by-18-f-fdg-pet-ct-and-by-posttherapy-radioiodine-spect-ct
#10
M Oporto, F Cepa, N Orta, S Rubí, H Navalón, C Peña
Radioiodine uptake in the thyroid tissue, metastasis of differentiated thyroid cancer (DTC), and in other tissues, depends on the expression of sodium-iodide symporter (NIS). Vascular permeability, effusions, inflammation, and other mechanisms may also play a role in the accumulation of radioactive iodine. A 63-year-old woman underwent radioiodine therapy, as well as a post-therapy whole-body scan,as she was suspected of having lung metastasis from thyroid carcinoma. The scan not only showed uptake at the lung metastasis but also a faint diffuse bilateral uptake in the posterior thorax...
May 15, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28468238/fasting-enhances-the-contrast-of-bone-metastatic-lesions-in-18-f-fluciclovine-pet-preclinical-study-using-a-rat-model-of-mixed-osteolytic-osteoblastic-bone-metastases
#11
Shuntaro Oka, Masaru Kanagawa, Yoshihiro Doi, David M Schuster, Mark M Goodman, Hirokatsu Yoshimura
(18)F-fluciclovine (trans-1-amino-3-(18)F-fluorocyclobutanecarboxylic acid) is an amino acid positron emission tomography (PET) tracer used for cancer staging (e.g., prostate and breast). Patients scheduled to undergo amino acid-PET are usually required to fast before PET tracer administration. However, there have been no reports addressing whether fasting improves fluciclovine-PET imaging. In this study, the authors investigated the influence of fasting on fluciclovine-PET using triple-tracer autoradiography with (14)C-fluciclovine, [5,6-³H]-2-fluoro-2-deoxy-d-glucose (³H-FDG), and (99m)Tc-hydroxymethylene diphosphonate ((99m)Tc-HMDP) in a rat breast cancer model of mixed osteolytic/osteoblastic bone metastases in which the animals fasted overnight...
April 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28467806/glut1-mediated-selective-tumor-targeting-with-fluorine-containing-platinum-ii-glycoconjugates
#12
Ran Liu, Zheng Fu, Meng Zhao, Xiangqian Gao, Hong Li, Qian Mi, Pengxing Liu, Jinna Yang, Zhi Yao, Qingzhi Gao
Increased glycolysis and overexpression of glucose transporters (GLUTs) are physiological characteristics of human malignancies. Based on the so-called Warburg effect, 18flurodeoxyglucose-positron emission tomography (FDG-PET) has successfully developed as clinical modality for the diagnosis and staging of many cancers. To leverage this glucose transporter mediated metabolic disparity between normal and malignant cells, in the current report, we focus on the fluorine substituted series of glucose, mannose and galactose-conjugated (trans-R,R-cyclohexane-1,2-diamine)-2-flouromalonato-platinum(II) complexes for a comprehensive evaluation on their selective tumor targeting...
June 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28467114/changes-in-the-distributions-of-fluorine-18-labelled-fluoro-2-deoxy-d-glucose-accumulation-into-tongue-related-muscles-after-dissection-in-patients-with-tongue-cancer
#13
Shinji Kito, Hirofumi Koga, Masafumi Oda, Tatsurou Tanaka, Ikuya Miyamoto, Masaaki Kodama, Manabu Habu, Shinya Kokuryo, Kenji Osawa, Noriaki Yamamoto, Shinobu Matsumoto-Takeda, Nao Wakasugi-Sato, Noriaki Kawanabe, Daigo Yoshiga, Shun Nishimura, Takaaki Joujima, Ayae Kito-Shingaki, Masataka Uehara, Masaaki Sasaguri, Yasuhiro Morimoto
OBJECTIVES: To elucidate the changes in the distributions of fluorine-18-labelled fluoro-2-deoxy-d-glucose ((18)F-FDG) accumulation in the tongue muscles of patients following four kinds of surgical operations for tongue cancers. METHODS: The changes in the distributions of (18)F-FDG accumulations in the tongue muscles on positron emission tomography (PET)-CT, in association with imaging findings on CT and MRI, were retrospectively analyzed before and after four kinds of surgical operations for 50 patients with tongue cancers...
June 20, 2017: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/28456080/radiosynthesis-and-biological-evaluation-of-n-2-18-f-fluoropropionyl-3-4-dihydroxy-l-phenylalanine-as-a-pet-tracer-for-oncologic-imaging
#14
Caihua Tang, Dahong Nie, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Xiaolan Tang
INTRODUCTION: Several (11)C and (18)F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, (18)F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new (18)F-labeled l-DOPA analogue, N-(2-[(18)F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine ([(18)F]FPDOPA) for tumor PET imaging are performed...
July 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28455978/n-acetylcysteine-breaks-resistance-to-trastuzumab-caused-by-muc4-overexpression-in-human-her2-positive-bc-bearing-nude-mice-monitored-by-89zr-trastuzumab-and-18f-fdg-pet-imaging
#15
Zéna Wimana, Geraldine Gebhart, Thomas Guiot, Bruno Vanderlinden, Denis Larsimont, Gilles Doumont, Gaetan Van Simaeys, Serge Goldman, Patrick Flamen, Ghanem Ghanem
Trastuzumab remains an important drug in the management of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer (BC). Several studies reported resistance mechanisms to trastuzumab, including impaired HER2-accessibility caused by mucin 4 (MUC4). Previously, we demonstrated an increase of Zirconium-89-radiolabeled-trastuzumab (89Zr-Trastuzumab) accumulation when MUC4-overexpressing BC-cells were challenged with the mucolytic drug N-Acetylcysteine (NAC). Hereby, using the same approach we investigated whether tumor exposure to NAC would also enhance trastuzumab-efficacy...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429815/cancer-vaccination-causes-prolonged-fdg-accumulation-in-subcutaneous-tissue
#16
Kathrin Kahnert, Diego Kauffmann-Guerrero, Amanda Tufman, Astrid Borgmeier, Rudolf M Huber, Frank Berger
No abstract text is available yet for this article.
April 21, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28408528/cerenkov-radiation-induced-photoimmunotherapy-with-18-f-fdg
#17
Yuko Nakamura, Tadanobu Nagaya, Kazuhide Sato, Shuhei Okuyama, Fusa Ogata, Karen J Wong, Stephen Adler, Peter L Choyke, Hisataka Kobayashi
Near infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that combines the specificity of antibodies for targeting tumors with toxicity induced by photo-absorbers after irradiation with NIR light. A limitation of NIR-PIT is the inability to deliver NIR light to a tumor located deep inside the body. Cerenkov radiation (CR) is ultraviolet and blue light which is produced by a charged particle travelling through a dielectric medium faster than the speed of light in that medium and is commonly produced during radioactive decay...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28402949/revisit-18f-fluorodeoxyglucose-oncology-positron-emission-tomography-systems-molecular-imaging-of-glucose-metabolism
#18
REVIEW
Baozhong Shen, Tao Huang, Yingying Sun, Zhongnan Jin, Xiao-Feng Li
18F-fluorodeoxyglucose (18F-FDG) positron emission tomography has become an important tool for detection, staging and management of many types of cancer. Oncology application of 18F-FDG bases on the knowledge that increase in glucose demand and utilization is a fundamental features of cancer. Pasteur effect, Warburg effect and reverse Warburg effect have been used to explain glucose metabolism in cancer. 18F-FDG accumulation in cancer is reportedly microenvironment-dependent, 18F-FDG avidly accumulates in poorly proliferating and hypoxic cancer cells, but low in well perfused (and proliferating) cancer cells...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382139/in-vivo-imaging-of-experimental-melanoma-tumors-using-the-novel-radiotracer-68-ga-nodaga-procainamide-pca
#19
István Kertész, András Vida, Gábor Nagy, Miklós Emri, Antal Farkas, Adrienn Kis, János Angyal, Noémi Dénes, Judit P Szabó, Tünde Kovács, Péter Bai, György Trencsényi
PURPOSE: The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study was to synthesize and investigate the melanin specificity of the novel (68)Ga-labeled NODAGA-PCA molecule in vitro and in vivo using PET techniques...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28298962/evaluation-of-response-to-immune-checkpoint-inhibitors-is-there-a-role-for-positron-emission-tomography
#20
EDITORIAL
Matteo Bauckneht, Roberta Piva, Gianmario Sambuceti, Francesco Grossi, Silvia Morbelli
Strategies targeting intracellular negative regulators such as immune checkpoint inhibitors (ICPIs) have demonstrated significant antitumor activity across a wide range of solid tumors. In the clinical practice, the radiological effect of immunotherapeutic agents has raised several more relevant and complex challenges for the determination of their imaging-based response at single patient level. Accordingly, it has been suggested that the conventional Response Evaluation Criteria in Solid Tumors assessment alone, based on dimensional evaluation provided by computed tomography (CT), tends to underestimate the benefit of ICPIs at least in a subset of patients, supporting the need of immune-related response criteria...
February 28, 2017: World Journal of Radiology
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