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Cancer AND FDG Accumulation

Zekiye Hasbek, Ömer Tamer Doğan, İsmail Sarı, Birsen Yücel, Mehmet Metin Şeker, Bülent Turgut, Serdar Berk, Yavuz Siliğ
OBJECTIVE: Mutations in the p53 gene are the most commonly observed genetic abnormalities in malignancies. The purpose of this study was to assess the diagnostic value of serum anti-p53 antibody (Ab) along with the correlation between serum anti-p53 Ab level and quantitative positron emission tomography (PET) parameters such as maximum standardized uptake value (SUVmax), SUVave, metabolic tumor volume, total lesion glycolysis (TLG) and tumor size. METHODS: Serum anti-p53 Ab level was studied in three groups...
October 5, 2016: Molecular Imaging and Radionuclide Therapy
Yasuhiro Kamata, Kazutaka Kikuta, Michiro Susa, Kazumasa Nishimoto, Aya Sasaki, Kaori Kameyama, Koji Murakami, Masaya Nakamura, Morio Matsumoto, Hideo Morioka
BACKGROUND: Hibernoma is a rare, benign, soft tissue tumor arising from brown fat that cannot be distinguished from other lipogenic tumors on computed tomography and magnetic resonance imaging (MRI) scans. On the other hand, the image of hibernoma on (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) is different from that of other lipogenic tumors. However, fewer studies have investigated the typical features of hibernoma on PET scans. We present the case of a hibernoma that was incidentally detected on (18)F-FDG-PET...
May 2016: Case Reports in Oncology
A Patnaik, L J Appleman, A W Tolcher, K P Papadopoulos, M Beeram, D W Rasco, G J Weiss, J C Sachdev, M Chadha, M Fulk, S Ejadi, J M Mountz, M T Lotze, F G S Toledo, E Chu, M Jeffers, C Peña, C Xia, S Reif, I Genvresse, R K Ramanathan
BACKGROUND: To evaluate the safety, tolerability, pharmacokinetics, and maximum tolerated dose (MTD) of copanlisib, a phosphatidylinositol 3-kinase inhibitor, in patients with advanced solid tumors or non-Hodgkin's lymphoma (NHL). PATIENTS AND METHODS: Phase I dose-escalation study including patients with advanced solid tumors or NHL, and a cohort of patients with type 2 diabetes mellitus. Patients received three weekly intravenous infusions of copanlisib per 28-day cycle over the dose range 0...
October 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Takayuki Kawai, Kentaro Yasuchika, Satoru Seo, Tatsuya Higashi, Takamichi Ishii, Yuya Miyauchi, Hidenobu Kojima, Ryoya Yamaoka, Hokahiro Katayama, Elena Yukie Yoshitoshi, Satoshi Ogiso, Sadahiko Kita, Katsutaro Yasuda, Ken Fukumitsu, Yuji Nakamoto, Etsuro Hatano, Shinji Uemoto
Purpose The current lack of tools for easy assessment of cancer stem cells (CSCs) prevents the development of therapeutic strategies for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker, and that positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) is an effective method for predicting postoperative outcome in HCC. Herein, we examined whether K19+ HCC-CSCs can be tracked using 18F-FDG-PET. Experimental Design K19 and glucose transporter-1 (GLUT1) expression was evaluated by immunohistochemistry in 98 HCC patients who underwent 18F-FDG-PET scans before primary tumor resection...
September 23, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Stefanie Pektor, Nicole Bausbacher, Georg Otto, Laura Lawaczeck, Stephan Grabbe, Mathias Schreckenberger, Matthias Miederer
INTRODUCTION: High uptake of [(18)F]-2-fluorodeoxyglucose ([(18)F]FDG) by inflammatory cells is a frequent cause of false positive results in [(18)F]FDG-positron-emission tomography (PET) for cancer diagnostics. Similar to cancer cells, immune cells undergo significant increases in glucose utilization following activation, e.g., in infectious diseases or after vaccination during cancer therapy. The aim of this study was to quantify certain immune effects in vitro and in vivo by [(18)F]FDG-PET after stimulation with TLR ligands and specific antibodies...
July 14, 2016: Nuclear Medicine and Biology
Tadashi Watabe, Hayato Ikeda, Shushi Nagamori, Pattama Wiriyasermkul, Yoko Tanaka, Sadahiro Naka, Yasukazu Kanai, Kohei Hagiwara, Masanao Aoki, Eku Shimosegawa, Yoshikatsu Kanai, Jun Hatazawa
PURPOSE: The purpose of this study was to evaluate the usefulness of L-4-borono-2-(18)F-fluoro-phenylalanine ((18)F-FBPA) as a tumor-specific probe, in comparison to (18)F-FDG and (11)C-methionine (Met), focusing on its transport selectivity by L-type amino acid transporter 1 (LAT1), which is highly upregulated in cancers. METHODS: Cellular analyses of FBPA were performed to evaluate the transportablity and Km value. PET studies were performed in rat xenograft models of C6 glioma (n = 12) and in rat models of turpentine oil-induced subcutaneous inflammation (n = 9)...
August 22, 2016: European Journal of Nuclear Medicine and Molecular Imaging
Gagan Deep, Rahul Kumar, Dhanya K Nambiar, Anil K Jain, Anand M Ramteke, Natalie J Serkova, Chapla Agarwal, Rajesh Agarwal
Hypoxia is associated with aggressive phenotype and poor prognosis in prostate cancer (PCa) patients suggesting that PCa growth and progression could be controlled via targeting hypoxia-induced signaling and biological effects. Here, we analyzed silibinin (a natural flavonoid) efficacy to target cell growth, angiogenesis and metabolic changes in human PCa, LNCaP and 22Rv1 cells under hypoxic condition. Silibinin treatment inhibited the proliferation, clonogenicity and endothelial cells tube formation by hypoxic (1% O2 ) PCa cells...
August 17, 2016: Molecular Carcinogenesis
Marko Dj Erak, Milana Mitrić, Branislav Djuran, Dusanka Tesanović, Sanja Vasiljev
INTRODUCTION: Application of imaging methods, namely computed tomography (CT), magnetic resonance imaging (MRI) and in recent years positron emission tomography/computed tomography (PET/CT), and the progress of computer technology have allowed the construction of effective computed systems for treatment planning (TPS) and introducing the concept of virtual simulation in 3D conformal radiotherapy planning. CASE REPORT: We hereby presented two patients with the diagnosis of non-small cell lung cancer who did PET/CT examination...
June 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Xiaona Jin, Naixin Liang, Mengzhao Wang, Yunxiao Meng, Bing Jia, Ximin Shi, Shanqing Li, Jinmei Luo, Yaping Luo, Quancai Cui, Kun Zheng, Zhaofei Liu, Jiyun Shi, Fang Li, Fan Wang, Zhaohui Zhu
Purpose To evaluate an integrin imaging approach based on single photon emission computed tomography (SPECT)/computed tomography (CT) by using technetium 99m ((99m)Tc)-dimeric cyclic arginine-glycine-aspartic acid (RGD) peptides with three polyethylene glycol spacers (3PRGD2) as the tracer to target the integrin αvβ3 expression in lung cancer and lymph node metastasis. Materials and Methods With ethics committee approval and written informed consent, 65 patients (41 male, 24 female; mean age, 60 years ± 11 [standard deviation]) with suspicious lung lesions were recruited with informed consent...
July 29, 2016: Radiology
Takuro Isoda, Shingo BaBa, Yasuhiro Maruoka, Yoshiyuki Kitamura, Keiichiro Tahara, Masayuki Sasaki, Hiroshi Honda
OBJECTIVES: Radioiodine therapy is an effective treatment for lung metastasis from thyroid cancer. However, cases of lung metastasis without iodine uptake are often encountered. In such cases, FDG accumulation in lung lesions is often observed. There is a reverse relationship between iodine and FDG accumulation in thyroid cancer lesions, the so-called "flip-flop" phenomenon. The aim of this study was to assess the relationship between patient age and the occurrence of the flip-flop phenomenon...
October 2016: Annals of Nuclear Medicine
Kazuma Kobayashi, Hiroaki Kurihara, Yoshiaki Watanabe, Naoya Murakami, Koji Inaba, Satoshi Nakamura, Akihisa Wakita, Hiroyuki Okamoto, Rei Umezawa, Kana Takahashi, Hiroshi Igaki, Yoshinori Ito, Seiichi Yoshimoto, Naoyuki Shigematsu, Jun Itami
BACKGROUND AND PURPOSE: Borono-2-(18)F-fluoro-phenylalanine ((18)F-BPA) has been used to estimate the therapeutic effects of boron neutron capture therapy (BNCT), while (18)F-fluorodeoxyglucose ((18)F-FDG) is the most commonly used positron emission tomography (PET) radiopharmaceutical in a routine clinical use. The aim of the present study was to evaluate spatial correlation between (18)F-BPA and (18)F-FDG uptakes using a deformable image registration-based technique. MATERIAL AND METHODS: Ten patients with head and neck cancer were recruited from January 2014 to December 2014...
September 2016: Applied Radiation and Isotopes
Maya K Arimoto, Tatsuya Higashi, Ryuichi Nishii, Shinya Kagawa, Masaaki Takahashi, Yoshihiko Kishibe, Hiroshi Yamauchi, Satoshi Ishitoya, Hiroyuki Oonishi, Yuji Nakamoto, Kaori Togashi
OBJECTIVE: α-N-methyl-(11)C-methylaminoisobutyric acid ((11)C-MeAIB) is a selective substrate of system A amino acid transport, and known to accumulate in malignant lesions. The aim of this study was to evaluate the utility of MeAIB PET for the assessment of prostate cancer, compared with FDG PET. METHODS: Thirty-four men (age range 57-77 years) with prostate cancer were prospectively enrolled, and underwent MeAIB PET and FDG PET between January 2011 and January 2013...
October 2016: Annals of Nuclear Medicine
Ba D Nguyen, Ann E McCullough
F-18 FDG PET/CT provides an accurate staging and post-therapeutic evaluation of melanoma based on high metabolic characteristics of its primary and secondary lesions. This functional imaging modality may, however, detect coexisting benign lesions of inflammatory or infectious origin mimicking malignancy thus interfering with the staging of cancer. The authors present a case of ruptured epidermal inclusion cyst exhibiting abnormal radiotracer accumulation on PET/CT in a patient with a history of recurrent metastatic melanoma...
2008: Radiology case reports
Kyohei Masai, Hiroyuki Sakurai, Shigeki Suzuki, Keisuke Asakura, Kazuo Nakagawa, Shun-Ichi Watanabe
OBJECTIVES: Colloid adenocarcinoma of the lung (CA) is a rare neoplasm that is associated with abundant mucin, which destroys alveoli. We evaluated the clinicopathological features of CA. METHODS: A total of 4,648 patients underwent surgical resection of primary lung cancer at our institution from 2002 to 2014. We analyzed the clinicopathological features of CA in six (0.13%) of these patients. RESULTS: All patients were asymptomatic. The median age was 60...
August 2016: Journal of Surgical Oncology
Cheng S Jin, Marta Overchuk, Liyang Cui, Brian C Wilson, Robert G Bristow, Juan Chen, Gang Zheng
BACKGROUND: The Magnetic Resonance Imaging (MRI)-guided focal laser therapy has shown early promise in Phase 1 trial treating low/intermediate-risk localized prostate cancer (PCa), but the lack of tumor selectivity and low efficiency of heat generation remain as drawbacks of agent-free laser therapy. Intrinsic multifunctional porphyrin-nanoparticles (porphysomes) have been exploited to treat localized PCa by MRI-guided focal photothermal therapy (PTT) with significantly improved efficiency and tumor selectivity over prior methods of PTT, providing an effective and safe alternative to active surveillance or radical therapy...
September 2016: Prostate
Nathaniel E Margolis, Linda Moy, Eric E Sigmund, Melanie Freed, Jason McKellop, Amy N Melsaether, Sungheon Gene Kim
PURPOSE: This study aims to investigate the feasibility of using simultaneous breast MRI and PET to assess the synergy of MR pharmacokinetic and fluorine-18 fluorodeoxyglucose (F-FDG) uptake data to characterize tumor aggressiveness in terms of metastatic burden and Ki67 status. METHODS: Twelve consecutive patients underwent breast and whole-body PET/MRI. During the MR scan, PET events were simultaneously accumulated. MR contrast kinetic model parametric maps were computed using the extended Tofts model, including the volume transfer constant between blood plasma and the interstitial space (K), the transfer constant from the interstitial space to the blood plasma (kep), and the plasmatic volume fraction (Vp)...
August 2016: Clinical Nuclear Medicine
Fei Yang, Lori Young, Perry Grigsby
OBJECTIVE: The aim of this study was to propose and evaluate a novel image metric for quantifying spatial heterogeneity of tumor F-fluorodeoxyglucose (FDG) uptake within the context of predicting response to chemoradiation in locally advanced cervical cancer. METHODS: Ninety patients with locally advanced cervical cancer treated with concomitant chemoradiation were included in this study. Each patient underwent two whole-body F-FDG positron emission tomography/computed tomography scans with one before the initiation of treatment for staging and the other at 12 weeks after treatment completion for response assessment...
May 2016: International Journal of Gynecological Cancer
Hiroko Seino, Shuichi Ono, Hiroyuki Miura, Satoko Morohashi, Yunyan Wu, Fumiyasu Tsushima, Yoshihiro Takai, Hiroshi Kijima
Several studies have noted benign thecoma‑fibroma tumors with positive F‑18 fluorodeoxyglucose (FDG) accumulation mimicking malignant ovarian tumors following F‑18 FDG positron emission tomography (PET). The present study analyzed four cases with false‑positive F‑18 FDG PET/computed tomography (CT) diagnoses of thecoma‑fibroma tumors as malignant tumors due to F‑18 FDG accumulation, compared with eight cases of FDG‑positive ovarian cancers and two cases of FDG‑negative fibromas. Hypoxia inducible factor (HIF)‑1α expression was examined in the six thecoma‑fibroma tumors using reverse transcription‑polymerase chain reaction (RT‑PCR)...
May 2016: Molecular Medicine Reports
S Kito, H Koga, M Kodama, M Habu, S Kokuryo, M Oda, K Matsuo, T Nishino, S Matsumoto-Takeda, M Uehara, D Yoshiga, T Tanaka, S Nishimura, I Miyamoto, M Sasaguri, K Tominaga, I Yoshioka, Y Morimoto
BACKGROUND: 18F-fluoro-2-deoxy-D-glucose (18F-FDG) accumulations are commonly seen in the neck-related muscles of the surgical and non-surgical sides after surgery with neck dissection (ND) for oral cancers, which leads to radiologists having difficulty in diagnosing the lesions. To examine the alterations in 18F-FDG accumulation in neck-related muscles of patients after ND for oral cancer. MATERIAL AND METHODS: 18F-FDG accumulations on positron emission tomography (PET)-computed tomography (CT) in neck-related muscles were retrospectively analyzed after surgical dissection of cervical lymph nodes in oral cancers...
2016: Medicina Oral, Patología Oral y Cirugía Bucal
Monica Sala-Rabanal, Bruce A Hirayama, Chiara Ghezzi, Jie Liu, Sung-Cheng Huang, Vladimir Kepe, Hermann Koepsell, Amy Yu, David R Powell, Bernard Thorens, Ernest M Wright, Jorge R Barrio
KEY POINTS: Glucose transporters are central players in glucose homeostasis. There are two major classes of glucose transporters in the body, the passive facilitative glucose transporters (GLUTs) and the secondary active sodium-coupled glucose transporters (SGLTs). In the present study, we report the use of a non-invasive imaging technique, positron emission tomography, in mice aiming to evaluate the role of GLUTs and SGLTs in controlling glucose distribution and utilization. We show that GLUTs are most significant for glucose uptake into the brain and liver, whereas SGLTs are important in glucose recovery in the kidney...
August 1, 2016: Journal of Physiology
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