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Cancer AND FDG Accumulation

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https://www.readbyqxmd.com/read/29925750/-differentiation-between-hepatic-focal-lesions-and-heterogenous-physiological-accumulations-by-early-delayed-scanning-in-18-f-fdg-pet-ct-examination
#1
Ayaka Ushio, Komei Takauchi, Makoto Kobayashi, Nobukazu Abe, Hiroomi Sumida, Yasushi Nagata, Kazuo Awai
PURPOSE: We examined whether early delayed scanning is useful for differentiation of liver lesion and heterogenous physiological accumulation in positron emission tomography (PET) examination. METHODS: The subjects of the study were 33 patients with colorectal cancer who underwent PET examination and were added early delayed scanning to distinguish between liver lesions and heterogenous physiological accumulation to conventional early images. We placed same regions of interest (ROI) in the tumor and hepatic parenchyma for early delayed and conventional early images...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29916092/multiple-hepatic-sclerosing-hemangiomas-a-case-report-and-review-of-the-literature
#2
Kyohei Yugawa, Tomoharu Yoshizumi, Noboru Harada, Takashi Motomura, Norifumi Harimoto, Shinji Itoh, Toru Ikegami, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Hepatic sclerosing hemangioma, a very rare benign tumor, is characterized by fibrosis and hyalinization occurring in association with degeneration of a hepatic cavernous hemangioma. Such atypical hemangiomas can be diagnosed incorrectly as primary or metastatic malignancies based on imaging characteristics. We present herein a rare case of giant and multiple hepatic sclerosing hemangiomas that are difficult to differentiate from hepatic malignancies and review the relevant literature...
June 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29880505/hexokinase-2-is-targetable-for-hk1-negative-hk2-positive-tumors-from-a-wide-variety-of-tissues-of-origin
#3
Shili Xu, Arthur Catapang, Hanna M Doh, Nicholas A Bayley, Jason T Lee, Daniel Braas, Thomas G Graeber, Harvey R Herschman
Although absent in most adult tissues, hexokinase 2 (HK2) is expressed in a majority of tumors and contributes to increased glucose consumption and to in vivo tumor 18 F-FDG PET signaling. Methods: Both HK2 knockdown and knockout approaches were used to investigate the role of HK2 in cancer cell proliferation, in vivo xenograft tumor progression and 18 F-FDG tumor accumulation. BioProfiler analysis monitored cell culture glucose consumption and lactate production; 18 F-FDG PET/CT monitored in vivo tumor glucose accumulation...
June 7, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29866101/solitary-metastasis-to-a-superior-mediastinal-lymph-node-after-distal-gastrectomy-for-gastric-cancer-a-case-report
#4
Naoki Kubo, Junichi Yoshizawa, Takaomi Hanaoka
BACKGROUND: Mediastinal lymph node metastases occasionally occur in patients of advanced gastric cancer of the cardia with esophageal invasion, but they rarely occur in patients with gastric cancer of other sites. This report describes a case of a solitary metastasis to t a superior mediastinal lymph node after distal gastrectomy for gastric cancer of the antrum. CASE PRESENTATION: A 70-year-old man underwent curative distal gastrectomy for advanced gastric cancer of the antrum (pT2pN2M0, stage IIB)...
June 4, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29753662/clinical-value-of-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-response-evaluation-after-primary-treatment-of-advanced-epithelial-ovarian-cancer
#5
J Hynninen, M Laasik, T Vallius, J Kemppainen, S Grönroos, J Virtanen, J Casado, S Hautaniemi, S Grenman, M Seppänen, A Auranen
AIMS: To prospectively evaluate the use of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) in the definition of the treatment response after primary treatment of advanced epithelial ovarian cancer (EOC). MATERIALS AND METHODS: Forty-nine patients with advanced EOC had an 18 F-FDG PET/CT scan before and after primary treatment. The treatment response was defined with the currently used radiological and serological Response Criteria in Solid Tumors (RECIST1...
May 9, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29695275/ectopic-thymoma-in-the-paratracheal-region-of-the-middle-mediastinum-a-rare-case-report-and-literature-review
#6
Toshiki Yajima, Akira Mogi, Kimihiro Shimizu, Takayuki Kosaka, Toshiteru Nagashima, Yoichi Ohtaki, Kai Obayashi, Seshiru Nakazawa, Misaki Iijima, Yuka Yoshida, Junko Hirato, Hiroyuki Kuwano
BACKGROUND: Thymomas generally arise from the thymus in the anterior mediastinum. Ectopic thymomas arising in the middle mediastinum are rare. We present a case of a thymoma arising from the ectopic thymic tissue in the right paratracheal region. CASE PRESENTATION: The patient was a 67-year-old male who underwent an enhanced-computed tomography examination as preoperative staging for colon cancer. A 20-mm nodule in the right paratracheal region was found incidentally...
April 25, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29673674/association-between-18f-fluorodeoxyglucose-pet-ct-and-histological-grade-of-uterine-endometrial-carcinoma
#7
Hiroaki Takagi, Toshiyuki Sasagawa, Takeo Shibata, Hiroshi Minato, Tomoko Takahashi
OBJECTIVE: The incidence of endometrial adenocarcinoma of the uterine corpus has increased in Japan. This study aimed to clarify the relationships between this type of cancer and various data provided by 18F-fluorodeoxyglucose (FDG) accumulation in positron emission tomography/computed tomography (PET/CT). MATERIALS AND METHODS: The study cohort thus comprised 27 patients with endometrial adenocarcinoma who had undergone PET/CT examinations from April 2008 to March 2015...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29670497/comparing-the-differential-diagnostic-values-of-18-f-alfatide-ii-pet-ct-between-tuberculosis-and-lung-cancer-patients
#8
Xiaoqing Du, Yu Zhang, Liping Chen, Baoming Mi, Qingjun You, Yuping Xu, Donghui Pan, Weixing Wan, Min Yang, Chunjing Yu
Purpose: To compare the differential diagnostic values of 18 F-Alfatide II PET/CT between tuberculosis and lung cancer patients and in patients with sarcoidosis and common inflammation. Methods: Nine inflammation patients (4 tuberculosis, 3 sarcoidosis, and 2 common inflammation) and 11 lung cancer patients were included in this study. All patients underwent 18 F-FDG and 18 F-Alfatide II PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard uptake value (SUVmean) were evaluated...
2018: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29656756/correlation-of-tumor-related-immunity-with-18f-fdg-pet-in-pulmonary-squamous-cell-carcinoma
#9
Norimitsu Kasahara, Kyoichi Kaira, Pinjie Bao, Tetsuya Higuchi, Yukiko Arisaka, Bilguun Erkhem-Ochir, Noriaki Sunaga, Yoichi Ohtaki, Toshiki Yajima, Takayuki Kosaka, Tetsunari Oyama, Takehiko Yokobori, Takayuki Asao, Masahiko Nishiyama, Yoshito Tsushima, Hiroyuki Kuwano, Kimihiro Shimizu, Akira Mogi
OBJECTIVES: 2-Deoxy-2-[fluorine-18] fluoro-d-glucose with positron emission tomography (18 F-FDG-PET) is a clinically useful tool for cancer evaluation. 18 F-FDG accumulation in tumor cells is known to be correlated with the presence of glucose transporter 1 (GLUT1) and hypoxia-inducible factor-1α (HIF-1α). Although anti-programmed death-1 (PD-1) antibody treatments have been approved, no suitable predictor of significant responders has been identified. Based on the existing information, we investigated the relationship between tumor immunity (including PD-L1) and 18 F-FDG uptake in patients with surgically resected pulmonary squamous-cell carcinoma (SQC)...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29519408/evaluation-of-third-treatment-week-as-temporal-window-for-assessing-responsiveness-on-repeated-fdg-pet-ct-scans-in-non-small-cell-lung-cancer-patients
#10
M Lazzeroni, J Uhrdin, S Carvalho, W van Elmpt, P Lambin, A Dasu, P Wersäll, I Toma-Dasu
PURPOSE: Early assessment of tumour response to treatment with repeated FDG-PET-CT imaging has potential for treatment adaptation but it is unclear what the optimal time window for this evaluation is. Previous studies indicate that changes in SUVmean and the effective radiosensitivity (αeff , accounting for uptake variations and accumulated dose until the second FDG-PET-CT scan) are predictive of 2-year overall survival (OS) when imaging is performed before radiotherapy and during the second week...
February 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29515407/tiny-obturator-node-metastasis-from-prostate-cancer-not-shown-by-fdg-pet-ct-ct-or-mri-detected-by-11-c-choline-pet-ct
#11
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Yusuke Kawanaka, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Neinei Kimura, Masataka Zouzumi, Seiichi Hirota, Koichiro Yamakado
We report a 65-year-old male with histopathologically proven prostate cancer and multiple pelvic node metastases using a robotic-assisted radical prostatectomy procedure plus extended pelvic lymph node dissection. Positron emission tomography (PET) scan findings demonstrated a moderate accumulation of 11 C-choline in a metastatic left obturator node sized 8 × 8 mm, though only a faint uptake of fluorodeoxyglucose (FDG) was noted. 11 C-choline PET/computed tomography (CT) may be useful for the diagnosis of a tiny metastatic lymph node not demonstrated by CT, magnetic resonance imaging, or FDG-PET/CT and to determine the need for an extended pelvic lymph node dissection...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29504964/active-bone-marrow-with-focal-fdg-accumulation-mimicking-bone-metastasis-with-a-case-of-early-esophageal-cancer
#12
Chio Okuyama, Naomi Sasaki, Motoki Nishimura, Shigenori Matsushima, Rika Yoshimatsu
A 68-year-old man underwent F-FDG PET/CT for the staging of esophageal carcinoma discovered by a medical checkup. Increased focal accumulation in some vertebrae, right humerus, and right femoral bone was noted on FDG-PET, whereas CT showed relatively high attenuation, and MRI showed hypointense lesions on T1- and T2-weighted imaging. A bone biopsy revealed mildly hypercellular bone marrow in the thoracic spine with FDG accumulation and markedly hypocellular bone marrow in the pelvic bone without an increased uptake...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29490919/mlh1-rhemac-hereditary-nonpolyposis-colorectal-cancer-syndrome-in-rhesus-macaques
#13
David W Brammer, Patrick J Gillespie, Mei Tian, Daniel Young, Muthuswamy Raveendran, Lawrence E Williams, Mihai Gagea, Fernando J Benavides, Carlos J Perez, Russell R Broaddus, Bruce J Bernacky, Kirstin F Barnhart, Mian M Alauddin, Manoop S Bhutani, Richard A Gibbs, Richard L Sidman, Renata Pasqualini, Wadih Arap, Jeffrey Rogers, Christian R Abee, Juri G Gelovani
Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques ( Macaca mulatta ) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD Anderson Cancer Center. The distinctive feature in these cases, based on PET/computed tomography (CT) imaging, was the presence of two or three tumor lesions in different locations, including proximal to the ileocecal juncture, proximal to the hepatic flexure, and/or in the sigmoid colon...
March 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29483436/-a-case-of-thyroid-metastasis-from-rectal-cancer
#14
Kenichiro Imura, Nobuki Yamaoka, Hideyuki Chou, Hirotaka Furuke, Sachie Tanaka, Tatsuya Kumano, Shuhei Komatsu, Katsumi Shimomura, Jun Ikeda, Fumihiro Taniguchi, Yasuhiro Shioaki
The patient was a 68-year-old man who underwent Hartmann's procedure for a fistula due to rectal cancer in August 2012. The cancer was tub2>tub1, pSE, pN2, pH2, pM1(intrapulmonary metastasis), stage IV. The patient received 5 courses of FOLFOX and bevacizumab as adjuvant chemotherapy. In December 2012, the patient was seen by Otolaryngology for hoarseness. A neck examination revealed induration of the left lobe of the thyroid, and FNA biopsy strongly suggested metastasis of rectal cancer to the thyroid. FDG-PET was performed and revealed extensive accumulation of FDG at the same site...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29483374/repeated-laparoscopic-resection-of-extra-regional-lymph-node-metastasis-after-laparoscopic-radical-resection-for-rectal-cancer
#15
Kazuhiro Sakamoto, Makoto Takahashi, Rina Takahashi, Shingo Kawano, Masaya Kawai, Kiichi Sugimoto, Hirohiko Kamiyama, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki
Here, we report a case of repeated laparoscopic resection of extra-regional lymph node metastases in a patient after laparoscopic surgery for rectal cancer. A 72-year-old woman was diagnosed with upper rectal cancer and underwent laparoscopic low anterior resection and D3 dissection. The pathological stage was considered as T3, N2b, M0, Stage IIIC. Six months after the operation, positron emission tomography-computed tomography (PET-CT) showed fluorodeoxyglucose (FDG) accumulation in the infra-renal para-aortic lymph nodes (PALNs)...
April 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29476053/tcf7l2-positively-regulates-aerobic-glycolysis-via-the-egln2-hif-1%C3%AE-axis-and-indicates-prognosis-in-pancreatic-cancer
#16
Jinfeng Xiang, Qiangsheng Hu, Yi Qin, Shunrong Ji, Wenyan Xu, Wensheng Liu, Si Shi, Chen Liang, Jiang Liu, Qingcai Meng, Dingkong Liang, Quanxing Ni, Jin Xu, Bo Zhang, Xianjun Yu
Patients with pancreatic ductal adenocarcinoma have much worse prognoses, and much effort has been directed toward understanding the molecular biological aspects of this disease. Accumulated evidence suggests that constitutive activation of the Wnt/β-catenin signalling contributes to the oncogenesis and progression of pancreatic cancer. Transcription factor 7-like2/transcription factor 4 (TCF7L2/TCF4), a β-catenin transcriptional partner, plays a vital role in the Wnt/β-catenin signalling pathway. In the present study, we investigated the clinicopathological significance of TCF7L2 in pancreatic cancer...
February 23, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29399968/utility-of-18f-fluorodeoxyglucose-positron-emission-tomography-in-the-differential-diagnosis-of-benign-and-malignant-gynaecological-tumours
#17
Hiroaki Takagi, Jinichi Sakamoto, Yasuhiro Osaka, Takeo Shibata, Satoko Fujita, Toshiyuki Sasagawa
INTRODUCTION: Positron emission tomography/computed tomography (PET/CT) involving 18F-fluorodeoxyglucose (FDG) is widely used for systemic cancer and recurrence diagnosis. However, the differential diagnosis of benign and malignant gynaecological tumours according to FDG accumulation is unclear. This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. METHODS: This study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F-FDG PET/CT...
February 5, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29399349/atypical-spleen-tuberculosis-in-a-melanoma-patient-accidentally-detected-during-a-18-f-fdg-pet-ct-study-case-report
#18
Paulina Cegla, Arkadiusz Spychala, Andrzej Marszalek, Ewa Wierzchoslawska, Witold Cholewinski
The present study, discussed a rare case of a 50-year-old woman who was treated for malignant melanoma and underwent 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18 F-FDG-PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29394669/-a-case-of-local-recurrence-with-negative-fdg-pet-findings-after-a-total-proctocolectomy-for-ulcerative-colitis-associated-with-colon-cancer-with-retroperitoneal-penetration
#19
Masumi Kumakura, Toshiro Ogura, Yu Muta, Tetsuya Ito, Azusa Yamamoto, Kunihiko Amano, Toru Ishiguro, Minoru Fukuchi, Erito Mochiki, Hideyuki Ishida
We report the case of a 55-year-old man who successfully underwent resection of a recurrence of ulcerative colitis(UC)- associated colon cancer located in the pancreatic body and left kidney. The patient had undergone an emergency laparotomy (total proctocolectomy with stapled ileal-pouch anal anastomosis)for the treatment of a descending colon cancer with retroperitoneal penetration associated with UC at the age of 50 years. At that time, histological examinations revealed a mucinous carcinoma that was classified as Stage II colon cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29387398/potential-role-of-post-treatment-follow-up-fdg-pet-ct-to-detect-mandibular-osteoradionecrosis-a-case-report
#20
Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Megumi Kishimoto, Yasumasa Kakei, Kazunobu Hashikawa, Takahide Komori
It was hypothesized that fluorodeoxyglucose (FDG) uptake on post-treatment follow-up positron emission tomography with computed tomography (PET CT; using PET CT to monitor and rule out recurrence and metastasis of head and neck carcinoma) would be useful for detecting and understanding the disease state of osteoradionecrosis (ORN) of the jaw. The present study included 14 patients who developed mandibular ORN following radiation therapy (RT) for head and neck cancer and underwent follow-up PET CT several times following RT...
January 2018: Molecular and Clinical Oncology
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