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Cancer AND FDG Accumulation

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https://www.readbyqxmd.com/read/29656756/correlation-of-tumor-related-immunity-with-18f-fdg-pet-in-pulmonary-squamous-cell-carcinoma
#1
Norimitsu Kasahara, Kyoichi Kaira, Pinjie Bao, Tetsuya Higuchi, Yukiko Arisaka, Bilguun Erkhem-Ochir, Noriaki Sunaga, Yoichi Ohtaki, Toshiki Yajima, Takayuki Kosaka, Tetsunari Oyama, Takehiko Yokobori, Takayuki Asao, Masahiko Nishiyama, Yoshito Tsushima, Hiroyuki Kuwano, Kimihiro Shimizu, Akira Mogi
OBJECTIVES: 2-Deoxy-2-[fluorine-18] fluoro-d-glucose with positron emission tomography (18 F-FDG-PET) is a clinically useful tool for cancer evaluation. 18 F-FDG accumulation in tumor cells is known to be correlated with the presence of glucose transporter 1 (GLUT1) and hypoxia-inducible factor-1α (HIF-1α). Although anti-programmed death-1 (PD-1) antibody treatments have been approved, no suitable predictor of significant responders has been identified. Based on the existing information, we investigated the relationship between tumor immunity (including PD-L1) and 18 F-FDG uptake in patients with surgically resected pulmonary squamous-cell carcinoma (SQC)...
May 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29519408/evaluation-of-third-treatment-week-as-temporal-window-for-assessing-responsiveness-on-repeated-fdg-pet-ct-scans-in-non-small-cell-lung-cancer-patients
#2
M Lazzeroni, J Uhrdin, S Carvalho, W van Elmpt, P Lambin, A Dasu, P Wersäll, I Toma-Dasu
PURPOSE: Early assessment of tumour response to treatment with repeated FDG-PET-CT imaging has potential for treatment adaptation but it is unclear what the optimal time window for this evaluation is. Previous studies indicate that changes in SUVmean and the effective radiosensitivity (αeff , accounting for uptake variations and accumulated dose until the second FDG-PET-CT scan) are predictive of 2-year overall survival (OS) when imaging is performed before radiotherapy and during the second week...
February 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29515407/tiny-obturator-node-metastasis-from-prostate-cancer-not-shown-by-fdg-pet-ct-ct-or-mri-detected-by-11-c-choline-pet-ct
#3
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Yusuke Kawanaka, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Neinei Kimura, Masataka Zouzumi, Seiichi Hirota, Koichiro Yamakado
We report a 65-year-old male with histopathologically proven prostate cancer and multiple pelvic node metastases using a robotic-assisted radical prostatectomy procedure plus extended pelvic lymph node dissection. Positron emission tomography (PET) scan findings demonstrated a moderate accumulation of11 C-choline in a metastatic left obturator node sized 8 × 8 mm, though only a faint uptake of fluorodeoxyglucose (FDG) was noted.11 C-choline PET/computed tomography (CT) may be useful for the diagnosis of a tiny metastatic lymph node not demonstrated by CT, magnetic resonance imaging, or FDG-PET/CT and to determine the need for an extended pelvic lymph node dissection...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29504964/active-bone-marrow-with-focal-fdg-accumulation-mimicking-bone-metastasis-with-a-case-of-early-esophageal-cancer
#4
Chio Okuyama, Naomi Sasaki, Motoki Nishimura, Shigenori Matsushima, Rika Yoshimatsu
A 68-year-old man underwent F-FDG PET/CT for the staging of esophageal carcinoma discovered by a medical checkup. Increased focal accumulation in some vertebrae, right humerus, and right femoral bone was noted on FDG-PET, whereas CT showed relatively high attenuation, and MRI showed hypointense lesions on T1- and T2-weighted imaging. A bone biopsy revealed mildly hypercellular bone marrow in the thoracic spine with FDG accumulation and markedly hypocellular bone marrow in the pelvic bone without an increased uptake...
April 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29490919/mlh1-rhemac-hereditary-nonpolyposis-colorectal-cancer-syndrome-in-rhesus-macaques
#5
David W Brammer, Patrick J Gillespie, Mei Tian, Daniel Young, Muthuswamy Raveendran, Lawrence E Williams, Mihai Gagea, Fernando J Benavides, Carlos J Perez, Russell R Broaddus, Bruce J Bernacky, Kirstin F Barnhart, Mian M Alauddin, Manoop S Bhutani, Richard A Gibbs, Richard L Sidman, Renata Pasqualini, Wadih Arap, Jeffrey Rogers, Christian R Abee, Juri G Gelovani
Over the past two decades, 33 cases of colonic adenocarcinomas have been diagnosed in rhesus macaques ( Macaca mulatta ) at the nonhuman primate colony of the Keeling Center for Comparative Medicine and Research at The University of Texas MD Anderson Cancer Center. The distinctive feature in these cases, based on PET/computed tomography (CT) imaging, was the presence of two or three tumor lesions in different locations, including proximal to the ileocecal juncture, proximal to the hepatic flexure, and/or in the sigmoid colon...
March 13, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29483436/-a-case-of-thyroid-metastasis-from-rectal-cancer
#6
Kenichiro Imura, Nobuki Yamaoka, Hideyuki Chou, Hirotaka Furuke, Sachie Tanaka, Tatsuya Kumano, Shuhei Komatsu, Katsumi Shimomura, Jun Ikeda, Fumihiro Taniguchi, Yasuhiro Shioaki
The patient was a 68-year-old man who underwent Hartmann's procedure for a fistula due to rectal cancer in August 2012. The cancer was tub2>tub1, pSE, pN2, pH2, pM1(intrapulmonary metastasis), stage IV. The patient received 5 courses of FOLFOX and bevacizumab as adjuvant chemotherapy. In December 2012, the patient was seen by Otolaryngology for hoarseness. A neck examination revealed induration of the left lobe of the thyroid, and FNA biopsy strongly suggested metastasis of rectal cancer to the thyroid. FDG-PET was performed and revealed extensive accumulation of FDG at the same site...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29483374/repeated-laparoscopic-resection-of-extra-regional-lymph-node-metastasis-after-laparoscopic-radical-resection-for-rectal-cancer
#7
Kazuhiro Sakamoto, Makoto Takahashi, Rina Takahashi, Shingo Kawano, Masaya Kawai, Kiichi Sugimoto, Hirohiko Kamiyama, Yutaka Kojima, Atsushi Okuzawa, Yuichi Tomiki
Here, we report a case of repeated laparoscopic resection of extra-regional lymph node metastases in a patient after laparoscopic surgery for rectal cancer. A 72-year-old woman was diagnosed with upper rectal cancer and underwent laparoscopic low anterior resection and D3 dissection. The pathological stage was considered as T3, N2b, M0, Stage IIIC. Six months after the operation, positron emission tomography-computed tomography (PET-CT) showed fluorodeoxyglucose (FDG) accumulation in the infra-renal para-aortic lymph nodes (PALNs)...
April 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29476053/tcf7l2-positively-regulates-aerobic-glycolysis-via-the-egln2-hif-1%C3%AE-axis-and-indicates-prognosis-in-pancreatic-cancer
#8
Jinfeng Xiang, Qiangsheng Hu, Yi Qin, Shunrong Ji, Wenyan Xu, Wensheng Liu, Si Shi, Chen Liang, Jiang Liu, Qingcai Meng, Dingkong Liang, Quanxing Ni, Jin Xu, Bo Zhang, Xianjun Yu
Patients with pancreatic ductal adenocarcinoma have much worse prognoses, and much effort has been directed toward understanding the molecular biological aspects of this disease. Accumulated evidence suggests that constitutive activation of the Wnt/β-catenin signalling contributes to the oncogenesis and progression of pancreatic cancer. Transcription factor 7-like2/transcription factor 4 (TCF7L2/TCF4), a β-catenin transcriptional partner, plays a vital role in the Wnt/β-catenin signalling pathway. In the present study, we investigated the clinicopathological significance of TCF7L2 in pancreatic cancer...
February 23, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29399968/utility-of-18f-fluorodeoxyglucose-positron-emission-tomography-in-the-differential-diagnosis-of-benign-and-malignant-gynaecological-tumours
#9
Hiroaki Takagi, Jinichi Sakamoto, Yasuhiro Osaka, Takeo Shibata, Satoko Fujita, Toshiyuki Sasagawa
INTRODUCTION: Positron emission tomography/computed tomography (PET/CT) involving 18F-fluorodeoxyglucose (FDG) is widely used for systemic cancer and recurrence diagnosis. However, the differential diagnosis of benign and malignant gynaecological tumours according to FDG accumulation is unclear. This study aimed to investigate the intensity of FDG uptake/metabolic activity for the differential diagnosis of benign and malignant gynaecological tumours. METHODS: This study included seven patients with physiological phenomena, 34 with benign tumours, 13 with borderline malignant tumours and 119 with malignant tumours who underwent 18F-FDG PET/CT...
February 5, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29399349/atypical-spleen-tuberculosis-in-a-melanoma-patient-accidentally-detected-during-a-18f-fdg-pet-ct-study-case-report
#10
Paulina Cegla, Arkadiusz Spychala, Andrzej Marszalek, Ewa Wierzchoslawska, Witold Cholewinski
The present study, discussed a rare case of a 50-year-old woman who was treated for malignant melanoma and underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F-FDG-PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29394669/-a-case-of-local-recurrence-with-negative-fdg-pet-findings-after-a-total-proctocolectomy-for-ulcerative-colitis-associated-with-colon-cancer-with-retroperitoneal-penetration
#11
Masumi Kumakura, Toshiro Ogura, Yu Muta, Tetsuya Ito, Azusa Yamamoto, Kunihiko Amano, Toru Ishiguro, Minoru Fukuchi, Erito Mochiki, Hideyuki Ishida
We report the case of a 55-year-old man who successfully underwent resection of a recurrence of ulcerative colitis(UC)- associated colon cancer located in the pancreatic body and left kidney. The patient had undergone an emergency laparotomy (total proctocolectomy with stapled ileal-pouch anal anastomosis)for the treatment of a descending colon cancer with retroperitoneal penetration associated with UC at the age of 50 years. At that time, histological examinations revealed a mucinous carcinoma that was classified as Stage II colon cancer...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29387398/potential-role-of-post-treatment-follow-up-fdg-pet-ct-to-detect-mandibular-osteoradionecrosis-a-case-report
#12
Masaya Akashi, Satoshi Wanifuchi, Junya Kusumoto, Megumi Kishimoto, Yasumasa Kakei, Kazunobu Hashikawa, Takahide Komori
It was hypothesized that fluorodeoxyglucose (FDG) uptake on post-treatment follow-up positron emission tomography with computed tomography (PET CT; using PET CT to monitor and rule out recurrence and metastasis of head and neck carcinoma) would be useful for detecting and understanding the disease state of osteoradionecrosis (ORN) of the jaw. The present study included 14 patients who developed mandibular ORN following radiation therapy (RT) for head and neck cancer and underwent follow-up PET CT several times following RT...
January 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29384832/phenotypic-appearances-of-prostate-utilizing-pet-mri-and-pet-ct-with-68ga-psma-radiolabelled-choline-and-68ga-dotatate
#13
Athar Haroon, Asim Afaq, Soujanya Nuthakki, Alex Freeman, Lorenzo Biassoni, Stefano Fanti, Mohsen Beheshti, Hikmat Jan, Sobhan Vinjamuri, Mark Emberton, Jamshed Bomanji
The objective of this study was to highlight the role of multimodality imaging and present the differential diagnosis of abnormal tracer accumulation in the prostate and periprostatic tissue. Our departments have performed molecular imaging of the prostate utilizing PET-CT and PET-MRI with a range of biomarkers including F-FDG, radiolabelled choline, Ga-DOTATATE PET-CT and Ga-PSMA images. We retrospectively reviewed the varying appearances of the prostate gland in different diseases and incidental findings in periprostatic region...
March 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29321928/lung-cancer-development-in-the-patient-with-granulomatosis-with-polyangiitis-during-long-term-treatment-with-cyclophosphamide-first-documented-case
#14
Midori Toriyama, Etsuko Tagaya, Tomoko Yamamoto, Mitsuko Kondo, Yoji Nagashima, Jun Tamaoki
A 65-year-old man was diagnosed with granulomatosis with polyangiitis (GPA) at the age of 47, when cytoplasmic anti-neutrophil cytoplasmic antibody (C-ANCA) serology was positive, and he had multiple nodular shadows in both lungs. He had been treated with prednisolone, cyclophosphamide (CPA) and plasma exchange. At the age of 64, a nodular shadow was newly detected in the right lower lung field and serum tumour marker increased. Subsequent positron emission tomography/computed tomography scan demonstrated accumulations of fluorodexyglucose (FDG) in the same area, mediastinum lymph nodes, thoracic wall, right iliac bone, and right retroperitoneum...
February 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29218614/-18-f-fluorodeoxyglucose-specimen-positron-emission-mammography-delineates-tumour-extension-in-breast-conserving-surgery-preliminary-results
#15
Gou Watanabe, M Itoh, X Duan, H Watabe, N Mori, H Tada, A Suzuki, M Miyashita, N Ohuchi, T Ishida
OBJECTIVES: We aimed to determine whether high-resolution specimen-positron emission mammography (PEM) using fluorodeoxyglucose (18 F-FDG) can reveal extension of breast cancer in breast-conserving surgery (BCS), and assess the safety of radiation exposure to medical staff. METHODS: Sixteen patients underwent positron emission tomography, and then BCS with intraoperative frozen section analysis on the same day. Resected specimens with remaining18 F-FDG accumulation were scanned by high-resolution PEM...
December 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29217733/sex-as-a-biological-variable-in-preclinical-imaging-research-initial-observations-with-18-f-fluorothymidine
#16
Szeman Ruby Chan, Kelley Salem, Justin Jeffery, Ginny L Powers, Yongjun Yan, Kooresh I Shoghi, Aparna M Mahajan, Amy M Fowler
The study objective was to investigate whether sex influences 3'-deoxy-3'-[18 F]fluorothymidine (18 F-FLT) uptake and tissue distribution in mouse models of cancer. Methods: 18 F-FLT biodistribution was measured in three strains of male and female mice (129S6/SvEv, athymic nude, and BALB/c).18 F-Fluoro-2-deoxy-2-D-glucose (18 F-FDG) biodistribution was performed for comparison.18 F-FLT uptake was also measured in female 129S6/SvEv mice bearing estrogen-dependent SSM3 mouse mammary tumors, male athymic nude mice bearing androgen-dependent CWR22 prostate cancer xenografts, and male and female athymic nude mice bearing estrogen-independent MDA-MB-231 human breast cancer xenografts...
December 7, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29145106/metachronous-mediastinal-lymph-node-metastasis-from-ascending-colon-cancer-a-case-report-and-literature-review
#17
Kosuke Toda, Kenji Kawada, Yoshiharu Sakai, Hiroshi Izumi
INTRODUCTION: Metachronous mediastinal lymph node metastasis without pulmonary metastasis is extremely rare in colorectal cancer, which makes the clinical diagnosis difficult and treatment strategy unclear. PRSENTATION OF CASE: A case was a 59-year-old man, who had undergone right hemicolectomy for ascending colon cancer 2 years and 8 months previously, presented with enlarged mediastinal lymph nodes.18 F-fluorodeoxyglucose (FDG) positron emission tomography revealed FDG was accumulated only into the mediastinal lymph nodes...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29142019/molecular-imaging-of-glut1-and-glut5-in-breast-cancer-a-multitracer-positron-emission-tomography-imaging-study-in-mice
#18
Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier-Mohamad Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West, Frank Wuest
Use of [18 F]FDG-positron emission tomography (PET) in clinical breast cancer (BC) imaging is limited mainly by insufficient expression levels of facilitative glucose transporter (GLUT)1 in up to 50% of all patients. Fructose-specific facilitative hexose transporter GLUT5 represents an alternative biomarker for PET imaging of hexose metabolism in BC. The goal of the present study was to compare the uptake characteristics of selected hexose-based PET radiotracers in murine BC model EMT6. Uptake of 1-deoxy-1-[18 F]fluoro-d-fructose (1-[18 F]FDF), 6-deoxy-6-[18 F]fluoro-d-fructose (6-[18 F]FDF), 1-deoxy-1-[18 F]fluoro-2,5-anhydro-mannitol (1-[18 F]FDAM), 2-deoxy-2-[18 F]fluoro-d-glucose (2-[18 F]FDG), and 6-deoxy-6-[18 F]fluoro-d-glucose (6-[18 F]FDG) was studied in EMT6 cells, tumors, and muscle and correlated to GLUT1 and GLUT5 expression levels...
February 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29130979/18f-famt-pet-is-useful-to-distinguish-between-specific-uptake-and-nonspecific-uptake-compared-to-18f-flourodeoxyglucose-position-emission-tomography-in-esophageal-cancer-patients
#19
Makoto Sohda, Tatsuya Miyazaki, Hiroaki Honjyo, Keigo Hara, Daigo Ozawa, Makoto Sakai, Takehiko Yokobori, Tetsuya Higuchi, Yoshito Tsushima, Hiroyuki Kuwano
BACKGROUND: L-[3-18F]-α-methyltyrosine (18F-FAMT) solely accumulates in tumor cells via an amino acid transport system. This selective uptake pattern results in a very high tumor-to-background ratio, enabling clear delineation of the tumor. The purpose of the present study was to assess the significance of 18F-FAMT PET, which shows little nonspecific uptake compared to 18F-flourodeoxyglucose position emission tomography (FDG PET) in esophageal cancer patients. METHODOLOGY: PET-CT studies with 18F-FAMT and 18F-FDG were performed as part of pretreatment work-up in 82 patients with histologically confirmed esophageal cancer...
November 2, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29109795/the-use-of-pet-imaging-for-prognostic-integrin-%C3%AE-2-%C3%AE-1-phenotyping-to-detect-non-small-cell-lung-cancer-and-monitor-drug-resistance-responses
#20
Chiun-Wei Huang, Wen-Chuan Hsieh, Shih-Ting Hsu, Yi-Wen Lin, Yi-Hsiu Chung, Wen-Chi Chang, Han Chiu, Yun Han Lin, Chung-Pu Wu, Tzu-Chen Yen, Feng-Ting Huang
PURPOSE: Growing evidence has demonstrated that aberrant expression of integrin α2β1 might contribute to the invasion, metastasis and drug resistance of non-small cell lung cancer (NSCLC). Thus, the integrin α2β1 targeting68 Ga-DOTA-A2B1 tracer was validated in NSCLC in contrast to accumulation of the clinically used18 F-FDG PET tracer to see if68 Ga-DOTA-A2B1-PET imaging can offer a valuable and critical diagnostic imaging criterion for the identification of phenotypes of aggressive lung cancer...
2017: Theranostics
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