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Cancer AND FDG

Pierpaolo Trimboli, Gaetano Paone, Giorgio Treglia, Camilla Virili, Teresa Ruberto, Luca Ceriani, Arnoldo Piccardo, Luca Giovanella
OBJECTIVE: Focal thyroid incidentalomas (TIs) are observed in 2% of 18 F-FDG PET/CT representing malignancy in one third of cases. Currently, due to the lack of evidence on their optimal management, guidelines suggest fine needle aspiration cytology (FNAC). Study aim was to evaluate the role of ultrasound evaluation according to EU-TIRADS to assess the risk of TIs and inform FNAC prescriptions. DESIGN: We retrospectively reviewed 18 F-FDG PET/CT TIs recorded during the period 2014-2017...
July 17, 2018: Clinical Endocrinology
Wei Diao, Fangfang Tian, Zhiyun Jia
PURPOSE: To evaluate the prognostic value of maximum standardized uptake values (SUVmax ) measured in the primary lesion and axillary lymph nodes (ALN) by pretreatment fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography (PET) or positron emission tomography/computed tomography (PET/CT) in patients with breast cancer. METHODS: We systematically searched PubMed, Embase, and the Cochrane Library. The primary prognosis endpoint was event-free survival (EFS), and the secondary endpoint was overall survival (OS)...
August 2018: European Journal of Radiology
Poorni M Manohar, Lauren J Beesley, Emily L Bellile, Francis P Worden, Anca M Avram
PURPOSE: There are no standardized prognostication algorithms for metastatic radioiodine-refractory (RAI-R) differentiated thyroid cancer (DTC). We hypothesize that [F]-FDG PET/CT may predict progression versus stability of disease based on quantitative analysis of metabolic tumor volume (MTV) and total lesion glycolysis (TLG). METHODS: Retrospective study of 62 patients with metastatic RAI-R DTC to determine clinical outcomes with median follow-up from initial diagnosis of 11...
July 14, 2018: Clinical Nuclear Medicine
Sangwon Han, Sungmin Woo, Chong Hyun Suh, Yeon Joo Kim, Jungsu S Oh, Jong Jin Lee
OBJECTIVE: The aim of this study was to perform a systematic review of the prognostic value of texture parameters derived by 18 F-fluorodeoxyglucose positron emission tomography (18 F-FDG PET) in patients with lung cancer. METHODS: PubMed and EMBASE databases were searched up to March 12, 2018, for original articles involving texture analysis for the prediction of prognosis in patients with lung cancer. Risk of bias in the studies was critically assessed using the QUIPS tool...
July 16, 2018: Annals of Nuclear Medicine
Akira Higashiyama, Tsuyoshi Komori, Hiroshi Juri, Yuki Inada, Haruhito Azuma, Yoshifumi Narumi
OBJECTIVE: 2-Fluorine-18-fluoro-2-deoxy-D-glucose positron emission tomography (18 F-FDG PET) imaging is not considered useful for assessing bladder cancer due to the physiological uptake of 18 F-FDG in the bladder. Despite reports of the detection of bladder cancer by washing out 18 F-FDG from the bladder, such methods are invasive and impractical in the routine practice. The purpose of this study was to evaluate prospectively the utility of oral hydration with 500 mL of water and voiding-refilling, a minimally invasive method that we introduced to enable detection of residual invasive bladder cancer on delayed 18 F-FDG PET imaging...
July 16, 2018: Annals of Nuclear Medicine
Binbin Yu, Xiaodong Zhu, Zhongguo Liang, Yongchu Sun, Wei Zhao, Kaihua Chen
Background: We undertook a meta-analysis to evaluate the clinical usefulness of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) for the detection of distant metastases in patients with non-small cell lung cancer (NSCLC) at initial staging. Materials and methods: All topic-related studies were comprehensively searched in the MEDLINE and Embase databases. We obtained the summary estimates and constructed the summary receiver operating characteristic curve for 18 F-FDG PET/CT using the bivariate regression model...
2018: Cancer Management and Research
Edouard Depardon, Salim Kanoun, Olivier Humbert, Aurélie Bertaut, Jean-Marc Riedinger, Ilan Tal, Jean-Marc Vrigneaud, Maud Lasserre, Michel Toubeau, Alina Berriolo-Riedinger, Inna Dygai-Cochet, Pierre Fumoleau, François Brunotte, Alexandre Cochet
AIM: Evaluate response and predict prognosis of patients with newly diagnosed metastatic breast cancer treated with first line systemic therapy using European Organization for Research and Treatment of Cancer (EORTC) criteria and PET Response Criteria in solid Tumours (PERCIST). METHODS: From December 2006 to August 2013, 57 women with newly diagnosed metastatic breast cancer were retrospectively evaluated. FDG-PET/CT was performed within one month before treatment and repeated after at least 3 cycles of treatment...
2018: PloS One
Hugo Levillain, Ivan Duran Derijckere, Gwennaëlle Marin, Thomas Guiot, Michaël Vouche, Nick Reynaert, Alain Hendlisz, Bruno Vanderlinden, Patrick Flamen
BACKGROUND: The aim of this work was to confirm that post-selective internal radiation therapy (SIRT) 90 Y-PET/CT-based dosimetry correlates with lesion metabolic response and to determine its correlation with overall survival (OS) in liver-only metastases from colorectal cancer (mCRC) patients treated with SIRT. Twenty-four mCRC patients underwent pre/post-SIRT FDG-PET/CT and post-SIRT 90 Y-PET/CT. Lesions delineated on pre/post-SIRT FDG-PET/CT were classified as non-metabolic responders (total lesion glycolysis (TLG)-decrease < 15%) and high-metabolic responders (TLG-decrease ≥ 50%)...
July 13, 2018: EJNMMI Research
Dalveer Singh, Roslyn Horneman, Navjot Kaur Nagra
OBJECTIVE: Prostate specific membrane antigen (PSMA) positron emission tomography diagnostic computed tomography (PET/CT) is gaining an increasing role in the staging of prostate cancer and restaging in cases of biochemical recurrence. Our understanding of PSMA affinity for incidental pathological and non-pathological entities is also maturing although certain cases do present as diagnostic and management dilemmas. SUBJECT AND METHODS: We present a case of a 55 years old man with prostate adenocarcinoma, with incidentally found pancreatic and thyroid lesions showing PSMA avidity...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Seol H Park, Minjung Seo, Hye-Jeong Choi, Kyungkyg Bae, Minseo Bang, Sungmin Jun
OBJECTIVE: To evaluate the reliability of a method using the peri-tumoral halo layer (PHL) for assessing tumor size in breast cancer patients on the fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18 F-FDG PET/CT) scan compared to MRI and pathology. SUBJECTS AND METHODS: Among 121 patients with breast cancer who underwent both 18 F-FDG PET/CT and MRI between March 2013 and June 2016, 59 patients were included in this study. Exclusion criteria were as follows: history of neoadjuvant therapy, history of pre-operative mammotome, insufficient pathologic/radiologic size report, clustered tumor, positive tumor resection margin, 18 F-FDG non-avid tumor...
July 12, 2018: Hellenic Journal of Nuclear Medicine
Xiuying Wang, Hui Cui, Guanzhong Gong, Zheng Fu, Jianlong Zhou, Jiabing Gu, Yong Yin, Dagan Feng
Quantitative measurement and analysis of tumor metabolic activities could provide a more optimal solution to personalized accurate dose painting. We collected PET images of 58 lung cancer patients, in which the tumor exhibits heterogeneous FDG uptake. We design an automated delineation and quantitative heterogeneity measurement of the lung tumor for dose-escalation. For tumor delineation, our algorithm firstly separates the tumor from its adjacent high-uptake tissues using 3D projection masks; then the tumor boundary is delineated with our stopping criterion of joint gradient and intensity affinities...
July 13, 2018: Scientific Reports
Sven van den Bosch, Tim Dijkema, Marielle E P Philippens, Chris H J Terhaard, Frank J P Hoebers, Johannes H A M Kaanders, Wim J G Oyen
BACKGROUND: In quantitative FDG-PET data analysis, normalization of the standardized uptake value (SUV) with an internal image-derived standard improves its reproducibility. In this study, the cervical spinal cord is proposed as an internal standard that is within the field of view of the radiotherapy planning PET/CT-scan in head and neck cancer. The aim is to evaluate if the tumor to cervical spinal cord standardized uptake ratio (SUR) can improve the reproducibility of a model to determine the metabolic tumor volume (MTV) on FDG-PET/CT in a multicenter setting...
July 10, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Swarna Arumugam, Raghu Raju, Andrew G Nicholson
Here we report a case of Pulmonary Hyalinising Granuloma (PHG) presenting with mild to moderate FDG positive nodules in an individual with a high risk of cancer. We explore the considerations in interpreting imaging findings and assess the benefits and risks of undertaking invasive investigations such as tissue biopsy. We highlight the importance of reaching an accurate diagnosis of this benign condition on our patients and their future outlook.
2018: Respiratory Medicine Case Reports
Katriann Arja, Mathias Elgland, Hanna Appelqvist, Peter Konradsson, Mikael Lindgren, K Peter R Nilsson
Small molecules with modalities for a variety of imaging techniques as well as therapeutic activity are essential, as such molecules render opportunities to simultaneously conduct diagnosis and targeted therapy, so called theranostics. In this regard, glycoporphyrins have proven useful as theranostic agents towards cancer, as well as noncancerous conditions. Herein, the synthesis and characterization of heterobifunctional glycoconjugated porphyrins with two different sugar moieties, a common monosaccharide at three sites, and a 2-fluoro-2-deoxy glucose (FDG) moiety at the fourth site are presented...
July 2018: ChemistryOpen
Katriann Arja, Mathias Elgland, Hanna Appelqvist, Peter Konradsson, Mikael Lindgren, K Peter R Nilsson
Invited for this month's cover picture is the group of Professor Peter Nilsson at the Department of Physics, Chemistry and Biology at Linköping University (Sweden). The cover picture shows a fluoro-glycoporphyrin that selectively targets cancer cells. The selectivity towards cancer cells are afforded due to proper functionalization of the porphyrin scaffold with specific carbohydrates, and the cancer cells can be visualized because of the intrinsic fluorescence from the porphyrin. The molecule also exhibits properties for photodynamic therapy and the incorporation of fluorine, in the form of 2-fluoro-2-deoxy glucose (FDG), offers the possibility to apply these compounds as 18F positron emission tomography (PET) tracers...
July 2018: ChemistryOpen
Mikhail Kesler, Charles Levine, Dov Hershkovitz, Eyal Mishani, Yoram Menachem, Hedva Lerman, Yaniv Zohar, Oren Shibolet, Einat Even-Sapir
Background: 68 Ga-Prostate Specific Membrane Antigen (68 Ga-PSMA), a positron emission tomography (PET) tracer that was recently introduce for imaging of prostate cancer, may accumulate in other solid tumors including Hepatocellular Carcinoma (HCC). The aim of the study was to assess the potential role of 68 Ga-PSMA PET-Computed Tomography (CT) for imaging of HCC. Material and Methods: A prospective pilot study in seven patients with HCC with 41 liver lesions: 37 suspected malignant lesions (tumor lesions) and 4 regenerative nodules...
July 12, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Ayman Soubra, Mehmet Gencturk, Jerry Froelich, Priya Balaji, Shilpa Gupta, Gautam Jha, Badrinath R Konety
PURPOSE: To determine the accuracy of 18 F-fluorodeoxyglucose with positron emission tomography and computed tomography (FDG-PET/CT) scans in assessing the response to neoadjuvant chemotherapy (NAC) in patients with bladder cancer scheduled to undergo radical cystectomy (RC). PATIENTS AND METHODS: All patients treated at our center for muscle-invasive bladder cancer (MIBC) were counseled and offered NAC before RC. FDG-PET/CT scans were performed before the initiation of chemotherapy and after completion of the regimen...
May 31, 2018: Clinical Genitourinary Cancer
Wenju Liu, Xiaorong Sun, Yiqiang Qi, Xiufen Jia, Yong Huang, Ning Liu, Jinhu Chen, Shuanghu Yuan
OBJECTIVE: This study explored whether integrated texture parameter (ITP) of the fluorine-18-fluorodeoxyglucose PET (F-FDG PET) is a stratification factor for the survival of nonoperative patients with locally advanced non-small-cell lung cancer (LA-NSCLC). PATIENTS AND METHODS: Thirty-five patients with LA-NSCLC treated with chemoradiotherapy or radiotherapy were included in the retrospective study. Eight principal components (PCs) were extracted from 72 F-FDG PET texture features (TFs) using PC analysis...
August 2018: Nuclear Medicine Communications
Batool Al Balooshi, Shabna Miyanath, Amr Elhennawy, Yaser Saeedi, Syed Hammad Tirmazy, Muhammed Muhasin, Bhavna Ray, Mouza Al Sharhan, Hassan Hotait, Yamina Houcinat, Tasnim Keloth
F-18 FDG is the most widely used tracer in molecular imaging and it is applied for many purposes mainly in malignant diseases. Incidental finding are common in FDG-PET/CT imaging and includes benign and malignant lesions. Among the rare tumors‎, adrenal oncocytomas are uncommon findings and incidental findings of thyroid malignancies are not rare. Oncocytoma is a rare adrenocortical tumor and majority of bulky adrenal tumors are benign with uncertain incident of malignancy. In this study, we are reporting a 37-year-old man with two incidental malignancies detected by FDG-PET-CT...
2018: Asia Oceania Journal of Nuclear Medicine & Biology
Jiang-Tao Zhong, Xiao-Xing Xie, Shui-Hong Zhou, Hong-Tian Yao, Zhe Chen, Ting-Ting Wu, Yang-Yang Bao, Qi Yu, He-Ming Han
Objective Carcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx. Methods A 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and 18 F-fluorodeoxyglucose positron emission tomography/CT (18 F-FDG PET/CT) showed a neoplasm on the left posterior hypopharyngeal wall. The patient underwent bilateral neck dissection and excision of the hypopharyngeal cancer followed by postoperative radiation therapy...
January 1, 2018: Journal of International Medical Research
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