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Cancer AND FDG

Agata K Pietrzak, Joanna Kazmierska, Andrzej Marszalek, Witold Cholewinski
BACKGROUND: The aim of this article was to evaluate the usefulness of sequential dual- time-point 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (DTP [18F]FDG PET/CT) in distinguishing physiologic, inflammatory and malignant palatine tonsils as difficult to differentiate in the oncological practice. METHODS: A total of 90 patients before the treatment underwent sequential DTP [18F]FDG PET/CT examinations. We analyzed 104 structures in 90 patients: 31 physiologic tonsils, 28 histopathologically confirmed inflammatory tonsils of non-specified origin, 31 histopathologically confirmed palatine tonsils cancer and 14 non-malignant contralateral tonsils in patients with histopathologically confirmed unilateral palatine tonsil malignancy...
September 13, 2018: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Sanaz Katal, Ali Gholamrezanezhad, Michael Kessler, Mojtaba Olyaei, Hossein Jadvar
Soft tissue sarcomas (STSs) account for less than 1% of adult solid tumors and about 7% of pediatric malignancies, causing 2% of cancer-related deaths. With the advent of PET-computed tomography (CT), the value of (18) fluorine-2-fluoro-2-deoxy-d-glucose (FDG) PET imaging to improve the management of STSs has been explored. FDG PET imaging has been found useful in restaging and treatment response assessment. This article reviews current knowledge and application of FDG PET-CT in initial diagnosis, staging, restaging, treatment response monitoring, and prognosis, with a brief overview of the most common histologic subtypes of STS...
October 2018: PET Clinics
Benjamin Houdu, Charline Lasnon, Idlir Licaj, Guy Thomas, Pascal Do, Anne-Valerie Guizard, Cédric Desmonts, Nicolas Aide
BACKGROUND: To determine EARL-compliant prognostic SUV thresholds in a mature cohort of patients with locally advanced NSCLC, and to demonstrate how detrimental it is to use a threshold determined on an older-generation PET system with a newer PET/CT machine, and vice versa, or to use such a threshold with non-harmonized multicentre pooled data. MATERIALS AND METHODS: This was a single-centre retrospective study including 139 consecutive stage IIIA-IIIB patients...
September 14, 2018: European Journal of Nuclear Medicine and Molecular Imaging
Junyan Xu, Yi Li, Silong Hu, Linjun Lu, Zhiqi Gao, Huiyu Yuan
OBJECTS: The purpose was to evaluate the correlation of the pre-treatment hematological parameters with metabolic parameters of primary tumor in baseline 18 F-FDG PET/CT in patients with colorectal cancer (CRC) and estimate the prognostic value of both. METHODS: We retrospectively investigated 231 patients with CRC who underwent baseline 18 F-FDG PET/CT. Routine blood sampling was tested in the same term. PET parameters in term of hematological parameters and pathological characteristics of primary tumor were compared...
September 14, 2018: Annals of Nuclear Medicine
Sung Uk Bae, Kyoung Sook Won, Bong-Il Song, Woon Kyung Jeong, Seong Kyu Baek, Hae Won Kim
BACKGROUND: The low sensitivity of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for the evaluation of metastatic lymph nodes (LNs) is mainly due to the partial volume effect in patients with rectal cancer. This retrospective study evaluated the diagnostic accuracy of F-18 FDG PET/CT with optimal cut-off values of the maximum standardized uptake value (SUVmax ), according to LN size, for the evaluation of regional LN in rectal cancer patients...
September 14, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Alessio Annovazzi, Sandra Rea, Patrizia Vici, Alessandra Fabi, Rosa Sciuto
OBJECTIVE: The aim was to investigate the diagnostic potential of dual-time-point F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) in patients with breast cancer with known or suspected liver metastases and to assess its clinical value on clinical management. PATIENTS AND METHODS: A total of 151 consecutive patients with breast cancer who underwent F-FDG PET/CT scan for staging or restaging, in whom an additional delayed scan of the liver was performed, were retrospectively evaluated...
September 13, 2018: Nuclear Medicine Communications
Stijn A Bos, Corey M Gill, Edgar L Martinez-Salazar, Martin Torriani, Miriam A Bredella
OBJECTIVE: To determine the role of brown adipose tissue (BAT) in cancer activity. MATERIALS AND METHODS: The study group comprised 142 patients (121 female, 21 male; mean age, 49 ± 16 years) who underwent F18-FDG PET/CT (PET/CT) for staging or surveillance of cancer and who were BAT-positive on PET/CT. BAT volume by PET/CT, abdominal (visceral and subcutaneous) fat and paraspinous muscle cross-sectional areas (CSA) were assessed. Groups with and without active cancer on PET/CT were compared using a two-sided paired t test...
September 13, 2018: Skeletal Radiology
Feng-Chun Zhang, Hai-Yan Xu, Jian-Jun Liu, Yuan-Fan Xu, Bin Chen, Yi-Jin Yang, Ning-Ning Yan, Shao-Li Song, Yu-Mei Lin, Ying-Chun Xu
The present study aimed to explore the value of fludeoxyglucose F 18 positron emission tomography-computed tomography (PET/CT) for the early prediction of chemotherapy remission rates and survival in patients with recurrent and metastatic breast cancer. A total of 24 patients diagnosed with recurrent or metastatic breast cancer between 2009 and 2014 were enrolled. All patients underwent a PET/CT examination prior to (PET/CT1) and following (PET/CT2) chemotherapy. Differences of PET/CT1 maximal standardized uptake values (SUVmax ), PET/CT2 SUVmax , ΔSUVmax and the ΔSUVmax % between objective remission (OR) and non-OR groups were measured...
October 2018: Oncology Letters
Wenchao Ma, Minshu Wang, Xiaofeng Li, Hui Huang, Yanjia Zhu, Xiuyu Song, Dong Dai, Wengui Xu
The aim of the present study was to investigate the prognostic value of quantitative [18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) parameters for patients with non-small cell lung cancer (NSCLC). The present study conducted a retrospective review of the medical records of 203 patients with NSCLC, of which 193 patients underwent baseline 18 F-FDG PET/CT prior to initial therapy. Multivariate analyses using Cox's proportional hazards regression were performed for the assessment of the association between initial PET/CT measurements and overall survival (OS)...
October 2018: Oncology Letters
Daisuke Shimizu, Norihiro Yuasa, Hideo Miyake, Eiji Takeuchi, Kanji Miyata, Shigeki Itoh
The standardized uptake value (SUV) is a marker of tumor glucose metabolism, detected using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and may reflect tumor aggressiveness. The purpose of this study was to evaluate the clinical significance of maximum SUV (SUVmax) of primary esophageal cancer (EC) lesions. A total of 86 patients with EC who underwent pre-treatment FDG-PET and R0-resection were included in our study. The mean patient age was 65 years, and 87% were men. Histologically, cancers included squamous cell carcinomas, adenocarcinomas, and other tumors in 72, 3, and 11 patients, respectively...
August 2018: Nagoya Journal of Medical Science
Rajiv Rai Sookha, Wenhua Zhi, Yanxia Shen, Cordelle Lazare, Ling Wang, Yifan Meng, Canhui Cao, Junbo Hu, Peng Wu
Objective: The purpose of this retrospective study was to investigate the role of 18F-Fluorodeoxyglucose Positron Emission Tomography (18 F-FDG PET/CT) and evaluate if combined elevated serum tumor markers levels improve the accuracy of 18 F-FDG PET/CT in detecting recurrence of cervical squamous cell carcinoma. Methods: A total number of 42 patients who were treated for cervical squamous cell carcinoma and had underwent 18 F-FDG PET/CT for suspected recurrence of cervical cancer were retrospectively reviewed in this study and their clinical, pathological and serological data were collected and analyzed...
2018: Journal of Cancer
Emmanuel Deshayes, Hélène de Forges, Julien Fraisse, Marie-Claude Eberlé, Sophie Guillemard, Anne Fallières, Jean-Pierre Pouget, Raphaël Tétreau, Pierre-Olivier Kotzki, Lore Santoro, Pierre Senesse, Nicolas Flori
BACKGROUND & AIMS: Nutrition support is recommended in cachexic patients with cancer. However, there is no clear evidence about its impact on tumour growth. Glycolysis, which is usually higher in cancer than normal cells, can be monitored by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) imaging that is widely used for cancer staging and therapy efficacy assessment. Here, we used 18 F-FDG PET/CT imaging to investigate whether artificial nutrition has an impact on tumour glucose metabolism in patients with cancer and cachexia...
August 31, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Aylin Eryilmaz, Arzu Cengiz, Yesim Basal, Ibrahim Meteoglu, Imran Kurt Omurlu, Yakup Yurekli
Objectives: To investigate the correlation between tumor stage, Ki-67, Bcl-2, hypoxia inducible factor-1α (HIF-1α), cyclin D1 and metabolic tumor volume (MTV), total lesion glycolysis (TLG), maximum standardized uptake value (SUVmax ) measured by 18 F fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in patients diagnosed with laryngeal cancer. Patients and Methods: In this study, included 25 consecutive laryngeal cancer patients (2 women, 23 men) diagnosed and treated in the Otorhinolaryngology Department of our tertiary care center...
July 2018: Journal of Cancer Research and Therapeutics
Tomoka Kitao, Tohru Shiga, Kenji Hirata, Mitsunori Sekizawa, Toshiki Takei, Katsushige Yamashiro, Nagara Tamaki
INTRODUCTION: Soft-tissue sarcomas (STS) are rare types of tumors that have variable levels of tumor differentiation. F-18 fluorodeoxyglucose positron emission tomography (FDG PET) has been established as an useful tool for STS patients, and the metabolic tumor volume (MTV) and total lesion glycolysis (TLG) are reported to be useful in various cancers. We compared the diagnostic value of four PET parameters (maximum standardized uptake value [SUVmax], SUVmean, MTV, and TLG) from two acquisition timings for predicting the expression of the pathological marker of cell proliferation Ki-67, based on pathological investigation...
September 8, 2018: Annals of Nuclear Medicine
G K Gedik, F Yilmaz
OBJECTIVE: Recurrence of colorectal cancer is mostly seen within the first 2 years after surgery. The most frequent site of recurrence is the postsurgical areas and its surroundings. The purpose of this study was to evaluate the usefulness of semiquantitative analysis of 18 Fluorine fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in determining recurrence of colorectal carcinoma in the operation site. MATERIAL AND METHODS: Files of 35 patients with colorectal carcinoma (25 men, 10 women, mean age: 59...
September 4, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Tibor Vag, Katja Steiger, Andreas Rossmann, Ulrich Keller, Aurelia Noske, Peter Herhaus, Johannes Ettl, Markus Niemeyer, Hans-Jürgen Wester, Markus Schwaiger
BACKGROUND: CXCR4 is a chemokine receptor frequently overexpressed in invasive breast cancer that has been shown to play a major role in signaling pathways involved in metastasis. The aim of this retrospective analysis was to assess the diagnostic performance of CXCR4-directed PET imaging in patients with breast cancer using the recently introduced CXCR4-targeted PET probe 68 Ga-Pentixafor. RESULTS: Thirteen patients with first diagnosis of breast cancer, four patients with recurrent disease after primary breast cancer, and one patient with axillary lymph node metastasis of unknown primary underwent CXCR4-targeted PET imaging using 68 Ga-Pentixafor...
September 6, 2018: EJNMMI Research
Hans-Jonas Meyer, Sandra Purz, Osama Sabri, Alexey Surov
PURPOSE: Histogram analysis is an emergent imaging technique to further analyze radiological images and to obtain imaging biomarker. In head and neck cancer, MRI and PET are routinely used in clinical practice. The aim of this study was to analyze associations between histogram based ADC parameters and complex FDG-PET derived parameters in head and neck squamous cell carcinoma (HNSCC). METHODS: 34 patients (26% female, mean age, 56.7 ± 10.2 years) with primary HNSCC were prospectively included into the study...
2018: PloS One
Gul E Aktas, Yekta A Karamustafaoğlu, Cenk Balta, Necdet Süt, İsmet Sarikaya, Ali Sarikaya
OBJECTIVE: Our aim was to assess the significance of metabolic positron emission tomography (PET) parameters for the prediction of occult mediastinal lymph node metastasis (OLM) and recurrence in patients with clinical-N0 nonsmall cell lung cancer (NSCLC) after surgical resection and lymph node dissection. MATERIALS AND METHODS: We evaluated 98 patients with NSCLC [52 adenocarcinoma (ADC), 46 squamous cell carcinoma (SQCC)] who had undergone initial/preoperative fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT)...
September 4, 2018: Nuclear Medicine Communications
Osman Aşıcıoğlu, Kemal Gungorduk, Aykut Ozdemir, Özgü Güngördük, Mehmet Gokçü, Levent Yaşar, Muzaffer Sancı
The purpose of this study was to develop a model predicting the probability of pelvic-paraaortic node metastases in high-risk endometrial cancer patients. This trial included 41 high-risk endometrial cancer patients. All of the patients underwent an 18-FDG PET-CT followed by surgical staging, including a pelvic and paraaortic lymphadenectomy. We developed a useful scoring system combining weighted risk factors derived from a regression model: (3 × presence PET-CT involvement) + (3 × PET-CT maximum standardised uptake value ≥20) + (2 × diabetes comorbidity) + (1 × age ≥60 years) + (1 × body mass index ≥30)...
September 6, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Shinji Nakashima, Toshiyuki Maeda, Satoshi Muraki, Taku Sakurada, Hisayoshi Osawa, Atsushi Watanabe
A 64-year-old man with pulmonary non-tuberculous mycobacteriosis(pulmonary NTM) who had been treated by antituberculous chemotherapy, developed a new nodule of 8 mm in size in the segment 3 of the right upper lobe. The cavity of 4.0 cm in size in the segment 1+2 of the left upper lobe due to Mycobacterium avium infection was preexisted. Radiologically, new nodule of the right lung was suspected to be lung cancer. Left upper lobe apical trisegmentectomy was performed at first. Three months later, enlarging of the right lung nodule with increased fluoro-2-deoxy-D-glucose(FDG) activity was noted, and the diagnosis of lung cancer was made by transbronchial lung biopsy(TBLB)...
September 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
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