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Cancer AND FDG

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https://www.readbyqxmd.com/read/28212997/differential-expression-and-prognostic-significance-of-glut1-according-to-histologic-type-of-non-small-cell-lung-cancer-and-its-association-with-volume-dependent-parameters
#1
Young Wha Koh, Su Jin Lee, Seong Yong Park
BACKGROUND: We evaluated glucose transporter type 1 (GLUT1) and carbonic anhydrase IX (CAIX) expression, together with volume-based(18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) parameters, in non-small cell lung cancer (NSCLC) patients, and examined the prognostic significance of those parameters according to its histologic subtype. METHOD: A total of 269 patients, who underwent surgical resection for NSCLC, were reviewed retrospectively. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were measured by preoperative (18)F-fluorodeoxyglucose positron emission tomography computed tomography...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28210093/mucosa-associated-lymphoid-tissue-lymphoma-with-unusual-18-f-fdg-hypermetabolism-arising-at-the-colorectal-anastomosis
#2
Na-Sha Zhang, Fang Shi, Li Kong, Hui Zhu
Mucosa-associated lymphoid tissue (MALT) lymphoma usually originates from the stomach and presents with low (18)F-fluorodeoxyglucose (FDG) avidity with average maximum standard uptake value of 3.6. Colorectal MALT lymphoma is a rare entity that contributes to 1.6% of all MALT lymphomas and < 0.2% of large intestinal malignancies. The case reported herein firstly revealed stage IIE MALT lymphoma with unexpected higher (18)F-FDG avidity of 18.9 arising at the colorectal anastomosis in a patient with a surgical history for sigmoid adenocarcinoma, which was strongly suspected as local recurrence before histopathological and immunohistochemical examinations...
January 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#3
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28205306/multi-site-quality-and-variability-analysis-of-3d-fdg-pet-segmentations-based-on-phantom-and-clinical-image-data
#4
Reinhard R Beichel, Brian J Smith, Christian Bauer, Ethan J Ulrich, Payam Ahmadvand, Mikalai M Budzevich, Robert J Gillies, Dmitry Goldgof, Milan Grkovski, Ghassan Hamarneh, Qiao Huang, Paul E Kinahan, Charles M Laymon, James M Mountz, John P Muzi, Mark Muzi, Sadek Nehmeh, Matthew J Oborski, Yongqiang Tan, Binsheng Zhao, John J Sunderland, John M Buatti
PURPOSE: Radiomics utilizes a large number of image-derived features for quantifying tumor characteristics that can in turn be correlated with response and prognosis. Unfortunately, extraction and analysis of such image-based features is subject to measurement variability and bias. The challenge for radiomics is particularly acute in Positron Emission Tomography (PET) where limited resolution, a high noise component related to the limited stochastic nature of the raw data, and the wide variety of reconstruction options confound quantitative feature metrics...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28202506/recurrent-patterns-of-dna-copy-number-alterations-in-tumors-reflect-metabolic-selection-pressures
#5
Nicholas A Graham, Aspram Minasyan, Anastasia Lomova, Ashley Cass, Nikolas G Balanis, Michael Friedman, Shawna Chan, Sophie Zhao, Adrian Delgado, James Go, Lillie Beck, Christian Hurtz, Carina Ng, Rong Qiao, Johanna Ten Hoeve, Nicolaos Palaskas, Hong Wu, Markus Müschen, Asha S Multani, Elisa Port, Steven M Larson, Nikolaus Schultz, Daniel Braas, Heather R Christofk, Ingo K Mellinghoff, Thomas G Graeber
Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and tumor suppressor genes. Using a pan-cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis-defined CNA signatures are predictive of glycolytic phenotypes, including (18)F-fluorodeoxy-glucose (FDG) avidity of patient tumors, and increased proliferation...
February 15, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28198519/correlation-of-hypoxia-inducible-transcription-factor-in-breast-cancer-and-suvmax-of-f-18-fdg-pet-ct
#6
Young-Ju Jeong, Jae-Won Jung, Yoon-Young Cho, Sung-Hwan Park, Hoon-Kyu Oh, Sungmin Kang
BACKGROUND: Tumor hypoxia induces the expression of several genes via the hypoxia-inducible transcription factor-1 alpha (HIF-1a). It is associated with the prognosis of several cancers. We studied the immunohistochemical expression of HIF-1a in patients with invasive ductal cancer (IDC) of the breast and the possible correlation with the maximum standardized uptake value of the primary tumor (pSUVmax) as well as other biological parameters. Prognostic significance of pSUVmax and expression of HIF-1a for the prediction of progression-free survival (PFS) was also assessed...
2017: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/28195911/a-restless-leg-syndrome-incidentally-detected-by-an-18f-fdg-positron-emission-tomography
#7
Jessica Ohnona, Arnaud Metlaine, Damien Leger, Jean-Noël Talbot
A case of a restless leg syndrome (RLS) was incidentally detected in a 49-year-old woman referred for an F-FDG PET/CT in monitoring her breast cancer. She was treated with chemotherapy and on long-term hormone therapy. Diffuse F-FDG uptake of calf muscles was visualized. Medical history revealed that the patient felt leg cramps in supine position, suggesting RLS. The diagnosis was confirmed using clinical rating scales and polysomnography. RLS being underdiagnosed, this type of FDG PET/CT incidental finding should prompt to check the presence of evocative symptoms and refer the patient to a physician specialized in sleep disorders...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28195905/value-of-intratumoral-metabolic-heterogeneity-and-quantitative-18f-fdg-pet-ct-parameters-to-predict-prognosis-in-patients-with-hpv-positive-primary-oropharyngeal-squamous-cell-carcinoma
#8
Esther Mena, Mehdi Taghipour, Sara Sheikhbahaei, Abhinav K Jha, Arman Rahmim, Lilja Solnes, Rathan M Subramaniam
OBJECTIVE: The aim of this study was to evaluate the impact of intratumoral metabolic heterogeneity and quantitative FDG PET/CT imaging parameters for predicting patient outcomes in primary oropharyngeal squamous cell cancer (OPSCC). PATIENTS AND METHODS: We retrospectively investigated 105 patients with HPV-positive OPSCC. SUVmax and metabolic tumor volume (MTV) were measured for the primary tumors and when available for the metastatic sites. Primary tumor intratumoral metabolic heterogeneity was calculated as the area under a cumulative SUV volume histograms curve (AUC-CSH)...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28194632/characterization-of-an-orthotopic-colorectal-cancer-mouse-model-and-its-feasibility-for-accurate-quantification-in-positron-emission-tomography
#9
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, Tim Van den Wyngaert, Rukun Hinz, Marleen Verhoye, Patrick Pauwels, Steven Staelens, Sigrid Stroobants
PURPOSE: Quantification in positron emission tomography (PET) imaging of an orthotopic mouse model of colorectal cancer (CRC) is challenging due to difficult tumor delineation. We aimed to establish a reproducible delineation approach, evaluate its feasibility for reliable PET quantification and compare its added translational value with its subcutaneous counterpart. PROCEDURES: A subcutaneous Colo205-luc2 tumor fragment harvested from a donor mouse was transplanted onto the caecum of nude mice, with (n = 10) or without (n = 10) the addition of an X-ray detectable thread...
February 13, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28191877/a-virtual-clinical-trial-comparing-static-versus-dynamic-pet-imaging-in-measuring-response-to-breast-cancer-therapy
#10
Kristen A Wangerin, Mark Muzi, Lanell Peterson, Hannah Linden, Alena Novakova, David Mankoff, Paul Kinahan
OBJECTIVE: We developed a method to evaluate variations in the PET imaging process in order to characterize the relative ability of static and dynamic metrics to measure breast cancer response to therapy in a clinical trial setting. METHODS: We performed a virtual clinical trial by generating 540 i.i.d. PET imaging study realizations for each of 22 original dynamic fluorodeoxyglucose (18F-FDG) breast cancer patient studies pre- and post-therapy. Each noise realization accounted for known sources of uncertainty in the imaging process, such as biological variability and SUV uptake time...
February 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28190636/correlation-of-18-f-fluorodeoxyglucose-positron-emission-tomography-parameters-with-patterns-of-disease-progression-in-locally-advanced-pancreatic-cancer-after-definitive-chemoradiotherapy
#11
J M Wilson, S Mukherjee, T B Brunner, M Partridge, M A Hawkins
AIMS: A proportion of patients with pancreatic cancer never develop metastatic disease. We evaluated a role for (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in identifying a subset of patients with locally advanced pancreatic cancer (LAPC) who never develop metastatic disease and only experience local disease and may therefore benefit from local treatment intensification. MATERIAL AND METHODS: Patients with histologically confirmed LAPC entered a single-centre phase II study of definitive upfront chemoradiotherapy (CRT)...
February 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28188325/correlation-between-tumour-characteristics-suv-measurements-metabolic-tumour-volume-tlg-and-textural-features-assessed-with-18-f-fdg-pet-in-a-large-cohort-of-oestrogen-receptor-positive-breast-cancer-patients
#12
Charles Lemarignier, Antoine Martineau, Luis Teixeira, Laetitia Vercellino, Marc Espié, Pascal Merlet, David Groheux
PURPOSE: The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC). METHODS: 171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an (18)F-FDG PET examination before NAC...
February 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28184015/dual-pi3k-mtor-inhibition-in-colorectal-cancers-with-apc-and-pik3ca-mutations
#13
Tyler M Foley, Susan N Payne, Cheri A Pasch, Alex E Yueh, Dana R Van De Hey, Demetra P Korkos, Linda Clipson, Molly E Maher, Kristina A Matkowskyj, Michael A Newton, Dustin A Deming
Therapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would benefit from targeting this pathway has yet to be identified. In human colorectal cancers, PIK3CA mutations most commonly occur concomitantly with loss of adenomatous polyposis coli (APC)...
9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28183074/a-comprehensive-comparison-of-ct-mri-positron-emission-tomography-or-positron-emission-tomography-ct-and-diffusion-weighted-imaging-mri-for-detecting-the-lymph-nodes-metastases-in-patients-with-cervical-cancer-a-meta-analysis-based-on-67-studies
#14
Bin Liu, Sujuan Gao, Shuofeng Li
OBJECT: In recent times, many published papers reported the diagnostic performance of CT, MRI, positron emission tomography (PET) using 2-[18F] fluoro-2-deoxy-D-glucose (FDG) and diffusion-weighted magnetic resonance imaging (DW-MRI) for detecting the lymph nodes (LNs) metastases in patients with cervical cancer. This study is aimed at assessing and comparing the diagnostic value of those non-invasive modalities in detecting the LNs metastases in cervical cancer patients. METHODS: Studies on the non-invasive modalities for the detection of metastatic LNs were searched in PubMed, Medline, Web of Science, Cochrane Library and Embase databases...
February 10, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28182730/68ga-dotatate-pet-ct-imaging-of-indeterminate-pulmonary-nodules-and-lung-cancer
#15
Ronald Walker, Stephen Deppen, Gary Smith, Chanjuan Shi, Jonathan Lehman, Jeff Clanton, Brandon Moore, Rena Burns, Eric L Grogan, Pierre P Massion
PURPOSE: 18F-FDG PET/CT is widely used to evaluate indeterminate pulmonary nodules (IPNs). False positive results occur, especially from active granulomatous nodules. A PET-based imaging agent with superior specificity to 18F-FDG for IPNs, is badly needed, especially in areas of endemic granulomatous nodules. Somatostatin receptors (SSTR) are expressed in many malignant cells including small cell and non-small cell lung cancers (NSCLCs). 68Ga-DOTATATE, a positron emitter labeled somatostatin analog, combined with PET/CT imaging, may improve the diagnosis of IPNs over 18F-FDG by reducing false positives...
2017: PloS One
https://www.readbyqxmd.com/read/28180987/preoperative-high-maximum-standardized-uptake-value-in-association-with-glucose-transporter-1-predicts-poor-prognosis-in-pancreatic-cancer
#16
Akira Chikamoto, Risa Inoue, Yoshiaki Komohara, Kentaro Sakamaki, Daisuke Hashimoto, Shinya Shiraishi, Hiroshi Takamori, Yo-Ichi Yamashita, Naoya Yoshida, Takeharu Yamanaka, Yasuyuki Yamashita, Hideo Baba
BACKGROUND: The diagnosis of malignant diseases worldwide has been determined using (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET). Glucose transporter type 1 (Glut-1) is a key protein associated with the accumulation of FDG in cancer cells. This study evaluated the relationship between Glut-1 expression and FDG accumulation to determine the usefulness of FDG-PET for prediction of long-term outcomes of pancreatic cancer. METHODS: The expression of Glut-1 was immunohistochemically examined in 138 surgically resected pancreatic cancer specimens...
February 8, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28180966/an-update-on-the-role-of-pet-ct-and-pet-mri-in-ovarian-cancer
#17
REVIEW
Benjapa Khiewvan, Drew A Torigian, Sahra Emamzadehfard, Koosha Paydary, Ali Salavati, Sina Houshmand, Thomas J Werner, Abass Alavi
This review article summarizes the role of PET/CT and PET/MRI in ovarian cancer. With regard to the diagnosis of ovarian cancer, the presence of FDG uptake within the ovary of a postmenopausal woman raises the concern for ovarian cancer. Multiple studies show that FDG PET/CT can detect lymph node and distant metastasis in ovarian cancer with high accuracy and may, therefore, alter the management to obtain better clinical outcomes. Although PET/CT staging is superior for N and M staging of ovarian cancer, its role is limited for T staging...
February 8, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28179354/accuracy-of-fdg-pet-ct-in-colorectal-peritoneal-carcinomatosis-potential-tool-for-evaluation-of-chemotherapeutic-response
#18
Gabriel Liberale, Céline Lecocq, Camilo Garcia, Kristof Muylle, Angélique Covas, Amélie Deleporte, Alain Hendlisz, Fikri Bouazza, Issam El Nakadi, Patrick Flamen
BACKGROUND/AIM: Neoadjuvant chemotherapy may be administered to patients with peritoneal carcinomatosis (PC) of colorectal cancer (CRC) origin. This study evaluated the performance of (18)fluorodeoxyglucose positron-emission tomography (FDG-PET)/computed tomography (CT) in detection of PC from CRC and correlated the most metabolically active quadrant with the most affected peritoneal area determined during surgery. PATIENTS AND METHODS: This retrospective study compared the performance of FDG-PET/CT for PC diagnosis in 26 patients with CRC with histopathologically-confirmed PC with a control group of 26 patients...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28178124/anaplastic-thyroid-carcinoma-and-foscarnet-use-in-a-multitarget-treatment-documented-by-18f-fdg-pet-ct-a-case-report
#19
Elisa Giannetta, Andrea M Isidori, Cosimo Durante, Cira Di Gioia, Flavia Longo, Vincenzo Tombolini, Nadia Bulzonetti, Chiara Graziadio, Riccardo Pofi, Daniele Gianfrilli, Antonella Verrienti, Raffaella Carletti, Sebastiano Filetti, Andrea Lenzi, Alberto Baroli
RATIONALE: The case reported the rapid remission of disease recurrence achieved adding foscarnet, a DNA polymerase inhibitor that interacts with fibroblast growth factor 2, to low molecular weight heparin and sunitinib for the first time in a patient with an anaplastic thyroid cancer (ATC). PATIENT CONCERNS: A 65-year-old woman with a multinodular goiter referred for a rapid enlargement of a nodule. Histological examination revealed an ATC with a little area of papillary thyroid cancer (PTC)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28169837/survival-outcomes-for-patients-with-indeterminate-18fdg-pet-scan-for-extrahepatic-disease-before-liver-resection-for-metastatic-colorectal-cancer-a-retrospective-cohort-study-using-a-prospectively-maintained-database-to-analyze-survival-outcomes-for-patients
#20
Geoffrey Yuet Mun Wong, Rajiv Kumar, Carol Beeke, Shahid Ullah, John Chen, Christos Karapetis, Timothy Price, Rob Padbury
OBJECTIVE: The aim of this study was to evaluate overall survival (OS) and cancer recurrence for patients with indeterminate positron emission tomography (PET) scan for extrahepatic disease (EHD) before liver resection (LR) for colorectal liver metastases (CLMs). SUMMARY OF BACKGROUND DATA: Indeterminate EHD as determined by PET imaging indicates a probability of extrahepatic malignancy and potentially excludes patients from undergoing LR for CLM. METHODS: In a retrospective analysis of prospectively collected data from February 2006 to December 2014, OS for patients with indeterminate EHD on FDG-PET scan before LR for CLM was performed using standard survival analysis methods, including Kaplan-Meier estimator and Cox proportional hazard models for multivariate analyses...
February 6, 2017: Annals of Surgery
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