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Cancer AND FDG

Misu Lee, Haeyong Ko, Mijin Yun
Various molecular targeted therapies and diagnostic modalities have been developed for the treatment of hepatocellular carcinoma (HCC); however, HCC still remains a difficult malignancy to cure. Recently, the focus has shifted to cancer metabolism for the diagnosis and treatment of various cancers, including HCC. In addition to conventional diagnostics, the measurement of enhanced tumor cell metabolism using F-18 fluorodeoxyglucose (18F-FDG) for increased glycolysis or C-11 acetate for fatty acid synthesis by positron emission tomography/computed tomography (PET/CT) is well established for clinical management of HCC...
December 2018: Yonsei Medical Journal
Florian C Maier, Anna-Maria Wild, Niklas Kirchen, Felix Holm, Kerstin Fuchs, Johannes Schwenck, Andreas Maurer, Stefan Wiehr
Here, we describe immuno-Cerenkov luminescence imaging (immuno-CLI) with a specific monoclonal antibody-based tracer for the detection of prostate tumors, which is used in preclinical positron emission tomography (PET) imaging. As PET isotopes generate a continuous spectrum of light in the ultraviolet/visible (UV/vis) wavelength range (Cerenkov luminescence, CL) in dielectric materials and consequently inside living tissues, these isotopes can also be detected by luminescence imaging performed with optical imaging (OI) systems...
September 8, 2018: Applied Radiation and Isotopes
Stephan Ellmann, Lisa Seyler, Jochen Evers, Henrik Heinen, Aline Bozec, Olaf Prante, Torsten Kuwert, Michael Uder, Tobias Bäuerle
Macrometastases in bone are preceded by bone marrow invasion of disseminated tumor cells. This study combined functional imaging parameters from FDG-PET/CT and MRI in a rat model of breast cancer bone metastases to a Model-averaged Neural Network (avNNet) for the detection of early metastatic disease and prediction of future macrometastases. Metastases were induced in 28 rats by injecting MDA-MB-231 breast cancer cells into the right superficial epigastric artery, resulting in the growth of osseous metastases in the right hind leg of the animals...
November 13, 2018: Bone
Alexander J Lin, Elizabeth Kidd, Farrokh Dehdashti, Barry A Siegel, Sasa Mutic, Premal H Thaker, Leslie S Massad, Matthew A Powell, David G Mutch, Stephanie Markovina, Julie Schwarz, Perry W Grigsby
PURPOSE: To report long-term outcomes of cervical cancer patients treated with intensity-modulated radiation therapy and 3D image-guided adapted brachytherapy (IMRT/3D-IGABT) compared to 2D external irradiation and 2D brachytherapy (2D EBRT/BT). METHODS AND MATERIALS: This study included patients with newly diagnosed cervical cancer and pre-treatment FDG-PET treated with curative-intent irradiation from 1997-2013. Treatment policy changed from 2D EBRT/BT to IMRT/3D-IGABT in 2005...
November 13, 2018: International Journal of Radiation Oncology, Biology, Physics
Elyse Colard, Sarkis Delcourt, Laetitia Padovani, Sébastien Thureau, Arthur Dumouchel, Pierrick Gouel, Justine Lequesne, Bardia Farman Ara, Pierre Vera, David Taïeb, Isabelle Gardin, Dominique Barbolosi, Sébastien Hapdey
BACKGROUND: In FDG-PET, SUV images are hampered by large potential biases. Our aim was to develop an alternative method (ParaPET) to generate 3D kinetic parametric FDG-PET images easy to perform in clinical oncology. METHODS: The key points of our method are the use of a new error model of PET measurement extracted from a late dynamic PET acquisition of 15 min, centered over the lesion and an image-derived input function (IDIF). The 15-min acquisition is reconstructed to obtain five images of FDG mean activity concentration and images of its variance to model errors of PET measurement...
November 15, 2018: EJNMMI Research
Masaya Taniwaki, Masahiro Yamasaki, Koto Kawata, Kazuma Kawamoto, Kunihiko Funaishi, Yu Matsumoto, Naoko Matsumoto, Nobuyuki Ohashi, Noboru Hattori
Carcinoma of unknown primary site (CUP) is diagnosed only in 2-9% of all cancer cases. Adenocarcinomas account for approximately 60% of CUP, and some of these are putative lung adenocarcinomas. The frequency of driver oncogene positivity in the putative lung adenocarcinomas is unknown, and the efficacy of targeting therapies for the driver oncogene is also unknown. This is the first case report of C-ros oncogene 1 (ROS1)-rearranged putative lung adenocarcinoma presenting as CUP showing a good response to ROS1 inhibitor therapy...
October 16, 2018: Oncotarget
Alessandro Ottaiano, Valerio Scotti, Chiara De Divitiis, Monica Capozzi, Carmen Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Valeria Vicario, Alfonso De Stefano, Salvatore Tafuto, Massimiliano Berretta, Guglielmo Nasti, Antonio Avallone
Background: There are very few clinical or prognostic studies on the role of SRT (Stereotactic Radiation Therapy) in the continuum of care of metastatic colorectal cancer (mCRC) patients. Patients and methods: Patients affected by oligo-mCRC were treated with SRT before or after front-line standard treatments. SRT was delivered according to a risk-adapted protocol. Total body CT (Computed Tomography) scan was done before therapy and every three months thereafter...
October 16, 2018: Oncotarget
Long Chen, Yongchun Zhou, Xiaoxia Tang, Conghui Yang, Yadong Tian, Ran Xie, Ting Chen, Jiapeng Yang, Mingwei Jing, Fukun Chen, Chun Wang, Hua Sun, Yunchao Huang
[18F]fluoro‑2‑deoxyglucose (FDG) positron emission tomography (PET)‑computed tomography (CT) is a functional imaging modality based on glucose metabolism. The association between the maximum standardized uptake value (SUVmax) from 18F‑FDG PET‑CT scanning and epidermal growth factor receptor (EGFR) mutation status has, to the best of our knowledge, not previously been fully elucidated, and the potential mechanisms by which EGFR mutations alter FDG uptake are largely unknown. A total of 157 patients who were pathologically diagnosed with non‑small cell lung cancer (NSCLC) who underwent EGFR mutation testing and PET‑CT pretreatment between June 2015 and October 2017 were retrospectively analyzed...
November 6, 2018: International Journal of Oncology
Beibei Li, Hongzan Sun, Siyu Zhang, Xiaoqi Wang, Qiyong Guo
BACKGROUND: Amide proton transfer (APT) imaging has shown great potential value in the diagnosis of cancer, but has yet not been applied in cervical carcinoma patients. PURPOSE: To investigate the utility of APT imaging in estimating histologic grades of squamous cell carcinoma of the cervix (SCCC), compared with the standardized uptake value (SUV). STUDY TYPE: Prospective. POPULATION: Thirty-one patients with SCCC (median age 51 years) were included...
November 14, 2018: Journal of Magnetic Resonance Imaging: JMRI
A P Caresia-Aróztegui, R C Delgado-Bolton, S Alvarez-Ruiz, M Del Puig Cózar-Santiago, J Orcajo-Rincon, M de Arcocha-Torres, M J García-Velloso
Cervical cancer is the second most common gynecological cancer worldwide. In locally advanced cervical cancer, 18 F-FDG PET/CT has become important in the initial staging, particularly in the detection of nodal and distant metastasis, aspects with treatment implications and prognostic value. The aims of this study were to review the role of 18 F-FDG PET/CT in uterine cervical cancer, according to the guidelines of the main scientific institutions (FIGO, NCCN, SEGO, SEOM, ESGO, and ESMO) and its diagnostic accuracy compared to conventional radiological techniques, as well as to review the acquisition protocol and its utility in radiotherapy planning, response assessment and detection of recurrence...
November 11, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
Louise Emmett, Megan Crumbaker, Bao Ho, Kathy Willowson, Peter Eu, Lalith Ratnayake, Richard Epstein, Ashley Blanksby, Lisa Horvath, Alex Guminski, Kate Mahon, Craig Gedye, Charlotte Yin, Phillip Stricker, Anthony M Joshua
BACKGROUND: 177 Lu-PSMA-617 (Lu-PSMA) is an emerging therapy in men with metastatic castration-resistant prostate cancer. Paired theranostic agents have the potential to visually identify phenotypes that will respond to targeted therapy. This study examined the value of 68 Ga-HBEDD PSMA-11; prostate-specific membrane antigen (PSMA) positron emission tomography (PET) in predicting treatment response and disease progression in Lu-PSMA therapy within the context of a phase 2 prospective pilot trial...
September 27, 2018: Clinical Genitourinary Cancer
Dietmar Tamandl, Barbara Fueger, Alexander Haug, Rainer Schmid, Judith Stift, Sebastian F Schoppmann, Aysegül Ilhan-Mutlu, Ahmed Ba-Ssalamah
PURPOSE: The aim of this study was to determine whether the combination of contrast-enhanced CT (CE-CT) and quantitative F-FDG PET parameters improves locoregional restaging in esophageal cancer (EC) after neoadjuvant therapy. METHODS: Eighty-eight consecutive patients with locally advanced esophageal cancer, who underwent restaging after neoadjuvant chemotherapy or chemoradiotherapy before esophagectomy, were included in this retrospective study. The diagnostic accuracy of CE-CT, visual F-FDG PET/CT (vPET/CT), and quantitative PET parameters was assessed for T and N staging...
November 10, 2018: Clinical Nuclear Medicine
Shin Young Jeong, Seong-Jang Kim, Kyoungjune Pak, Sang-Woo Lee, Byeong-Cheol Ahn, Jaetae Lee
BACKGROUND: Several studies have reported the prognostic value of F-fluorodeoxyglucose (F-FDG) bone marrow uptake (BMU) measured by F-FDG positron emission tomography (F-FDG PET) in various cancers. We performed a meta-analysis to evaluate the prognostic value of F-FDG BMU in patients with solid tumors. METHODS: Systematic searches of MEDLINE and Embase databases were performed using the keywords "F-FDG," "bone marrow," and "prognosis." All published human studies of the prognostic value of F-FDG BMU in patients with solid tumors were searched...
October 2018: Medicine (Baltimore)
Soo Jin Lee, Min Sung Chung, Su-Jin Shin, Yun Young Choi
Mechanisms of technetium-99m sesta-methoxyisobutylisonitrile (sestamibi) and F-fluorodeoxyglucose (FDG) uptake by tumor are different. The purpose of this study was to investigate the association between the tumor uptake of these 2 tracers in invasive ductal carcinoma and to examine thecorrelation of uptake of each tracer with prognostic factors and tumor molecular subtypes.A total of 96 patients with invasive ductal carcinoma who underwent preoperative breast-specific gamma imaging and FDG positron-emission tomography/computed tomography were retrospectively enrolled...
October 2018: Medicine (Baltimore)
Artor Niccoli Asabella, Alessandra Di Palo, Corinna Altini, Margherita Fanelli, Cristina Ferrari, Valentina Lavelli, Girolamo Ranieri, Cosmo D Gadaleta, Giuseppe Rubini
OBJECTIVE: To evaluate the role of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT) in therapy response assessment according modified response evaluating criteria of solid tumors (mRECIST) and the predictive role of volume-based semi-quantitative parameters in patients with malignant pleural mesothelioma (MPM). Furthermore modified RECIST criteria for MPM mRECIST and the European Organization for Research and Treatment of Cancer (EORTC) criteria were compared and the predictive role of 18 F-FDG PET/CT in the post-therapy outcome...
November 10, 2018: Hellenic Journal of Nuclear Medicine
Niels Hansen, Guido Widman, Svenja Stuff, Albert J Becker, Juri-Alexander Witt, Hojjat Ahmadzadehfar, Christoph Helmstaedter, Christian E Elger
OBJECTIVE: Paraneoplastic limbic encephalitis (LE) occurs frequently with considerable variability according to literature reports. We thus determined the cancer frequency in mixed LE subtypes sharing the diagnosis of temporal lobe epilepsy (TLE). METHODS: All patients underwent magnetic resonance imaging (MRI) of the brain, electroencephalography (EEG) recordings, neuropsychological testing, immunohistochemistry, and clinical examination together with whole body 2-fluor-2-desoxy-d-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) to detect cancer in this observatory study...
November 5, 2018: Epilepsy & Behavior: E&B
Sung Gwe Ahn, Chang Ik Yoon, Jae Hoon Lee, Hye-Sun Lee, So Eun Park, Yoon Jin Cha, Chihwan Cha, Soong June Bae, Kyung-A Lee, Joon Jeong
On the basis of TP53 mutations and standardized uptake values (SUVs) from 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET), we sought to enhance our knowledge of the biology underlying low progesterone receptor (PR) expression in estrogen receptor (ER)-positive/human epidermal growth factor receptor-2 (HER2)-negative tumors. This study included 272 patients surgically treated for ER-positive, HER2-negative breast cancer and who had undergone TP53 gene sequencing. Of these, 229 patients also underwent 18F-FDG PET or PET/CT...
November 1, 2018: Endocrine-related Cancer
Wei Chen, Lei Zhu, Xiaozhou Yu, Qiang Fu, Wengui Xu, Ping Wang
PURPOSE: We aimed to quantitatively evaluate volumetric metabolic tumor burden including metabolic tumor volume and total lesion glycolysis in different molecular subtypes of breast cancer using 18F-fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/CT). METHODS: This study involved 99 female patients with pathologic diagnosis of primary breast cancer, who underwent 18F-FDG PET/CT before any therapy. Patients were divided into subtypes of luminal A, luminal B, ERBB2+, and basal-like based on the immunohistochemistry results...
November 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Maho Ogawa, Tsutomu Namikawa, Toyokazu Oki, Jun Iwabu, Masaya Munekage, Hiromichi Maeda, Takahiko Tamura, Tomoaki Yatabe, Hiroyuki Kitagawa, Ken Dabanaka, Takeki Sugimoto, Michiya Kobayashi, Kazuhiro Hanazaki
The most common sites of breast cancer metastasis are the bone, liver, lung and brain, while gastrointestinal metastasis from breast cancer is rare. We herein present the case of a 68-year-old woman who was admitted to our department with nausea and appetite loss. The patient's medical history included right mastectomy with sentinel lymph node biopsy 5 years earlier for invasive lobular carcinoma, measuring 6.2 cm in greatest diameter, without lymphovascular invasion. Two years after the surgery, the patient developed brain metastasis and underwent metastasectomy to control the neurological symptoms, including unsteadiness and asthenia...
November 2018: Molecular and Clinical Oncology
Masatoyo Nakajo, Megumi Jinguji, Tetsuya Shinaji, Masaya Aoki, Atsushi Tani, Yoshiaki Nakabeppu, Masayuki Nakajo, Masami Sato, Takashi Yoshiura
PURPOSE: To examine whether the heterogeneous texture parameters in primary tumor can predict prognosis of patients with non-small cell lung cancer (NSCLC) received surgery after 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT). PROCEDURE: This retrospective study included 55 patients with NSCLC who underwent [18 F]FDG-PET/CT before surgery from January 2011 and December 2015. SUV-related (SUVmax and SUVmean), volumetric (metabolic tumor volume [SUV ≥ 2...
November 5, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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