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Adolescent + idiopathic + scoliosis

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https://www.readbyqxmd.com/read/28533693/dna-methylation-at-the-mu-1-opioid-receptor-gene-oprm1-promoter-predicts-preoperative-acute-and-chronic-postsurgical-pain-after-spine-fusion
#1
Vidya Chidambaran, Xue Zhang, Lisa J Martin, Lili Ding, Matthew T Weirauch, Kristie Geisler, Bobbie L Stubbeman, Senthilkumar Sadhasivam, Hong Ji
INTRODUCTION: The perioperative pain experience shows great interindividual variability and is difficult to predict. The mu-1 opioid receptor gene (OPRM1) is known to play an important role in opioid-pain pathways. Since deoxyribonucleic acid (DNA) methylation is a potent repressor of gene expression, DNA methylation was evaluated at the OPRM1 promoter, as a predictor of preoperative, acute, and chronic postsurgical pain (CPSP). METHODS: A prospective observational cohort study was conducted in 133 adolescents with idiopathic scoliosis undergoing spine fusion under standard protocols...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28529002/isyqol-a-rasch-consistent-questionnaire-for-measuring-health-related-quality-of-life-in-adolescents-with-spinal-deformities
#2
Antonio Caronni, Luciana Sciumè, Sabrina Donzelli, Fabio Zaina, Stefano Negrini
BACKGROUND CONTEXT: - Spinal deformities are commonly associated with poor HRQOL. Several questionnaires (e.g. SRS-24 and SRS-22) have been developed to evaluate HRQOL in these conditions. In adults as well as during growth, the HRQOL is considered one of the most relevant outcomes of both conservative and surgical treatment. Rasch analysis is a powerful statistical technique for developing high quality and valid questionnaires. The SRS-24 and SRS-22 have been evaluated using the Rasch analysis, but showed poor measurement properties...
May 18, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28520681/delayed-dural-leak-following-posterior-spinal-fusion-for-idiopathic-scoliosis-using-all-posterior-pedicle-screw-technique
#3
Lorena V Floccari, A Noelle Larson, Anthony A Stans, Jeremy Fogelson, Iikka Helenius
BACKGROUND: In pediatric patients, pedicle screws are malpositioned 5% to 15% of the time. Complications associated with malpositioned screws are infrequently reported in the literature. We present a series of adolescent idiopathic scoliosis (AIS) patients who presented in a delayed manner with positional headache and chronic dural leak adjacent to the pedicle screw tract. METHODS: Scoliosis databases at 2 centers were reviewed, and cases of delayed positional headaches following posterior spinal fusion for AIS were identified...
May 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28516166/onset-and-remodeling-of-coronal-imbalance-after-selective-posterior-thoracic-fusion-for-lenke-1c-and-2c-adolescent-idiopathic-scoliosis-a-pilot-study
#4
Masayuki Ishikawa, Kai Cao, Long Pang, Nobuyuki Fujita, Mitsuru Yagi, Naobumi Hosogane, Takashi Tsuji, Masafumi Machida, Shinichi Ishihara, Makoto Nishiyama, Yasuyuki Fukui, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
BACKGROUND: Postoperative coronal imbalance is a significant problem after selective thoracic fusion for primary thoracic and compensatory lumbar curves in adolescent idiopathic scoliosis (AIS). However, longitudinal studies on postoperative behavior of coronal balance are lacking. This multicenter retrospective study was conducted to analyze factors related to onset and remodeling of postoperative coronal imbalance after posterior thoracic fusion for Lenke 1C and 2C AIS. METHODS: Twenty-one Lenke 1C or 2C AIS patients, who underwent posterior thoracic fusion ending at L3 or above, were included with a minimum 2-year follow-up...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28503541/effects-of-12-week-core-stabilization-exercise-on-the-cobb-angle-and-lumbar-muscle-strength-of-adolescents-with-idiopathic-scoliosis
#5
Kwang-Jun Ko, Seol-Jung Kang
To identify the effects of core stabilization exercise on the Cobb angle and lumbar muscle strength of adolescent patients with idiopathic scoliosis. Subjects in the present study consisted of primary school students who were confirmed to have scoliosis on radiologic examination performed during their visit to the National Fitness Center in Seoul, Korea. Depending on whether they participated in a 12-week core stabilization exercise program, subjects were divided into the exercise (n=14, age 12.71±0.72 years) or control (n=15, age 12...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28500653/blood-transfusion-in-the-surgical-treatment-of-adolescent-idiopathic-scoliosis-a-single-center-experience-of-patient-blood-management-in-210-cases
#6
Søren Ohrt-Nissen, Naeem Bukhari, Casper Dragsted, Martin Gehrchen, Pär I Johansson, Jesper Dirks, Jakob Stensballe, Benny Dahl
BACKGROUND: The surgical treatment of adolescent idiopathic scoliosis can be associated with substantial blood loss, requiring allogeneic red blood cell (RBC) transfusion. This study describes the use of RBC and the effect of a standardized perioperative patient blood management program. STUDY DESIGN AND METHODS: Patients treated with posterior instrumented fusion were consecutively enrolled over a 6-year period. Patient blood management strategies were implemented in 2011, including prophylactic tranexamic acid, intraoperative permissive hypotension, restrictive fluid therapy (including avoidance of synthetic colloids), restrictive RBC trigger according to institutional standardized protocol, the use of cell savage, and goal-directed therapy according to thrombelastography...
May 12, 2017: Transfusion
https://www.readbyqxmd.com/read/28489761/quality-of-life-in-adolescent-patients-with-idiopathic-scoliosis-after-brace-treatment-a-meta-analysis
#7
Zeng-Dong Meng, Tian-Peng Li, Xu-Hua Xie, Chong Luo, Xing-Ye Lian, Ze-Yu Wang
BACKGROUND: Whether brace-treated adolescents with idiopathic scoliosis (AIS) have improved quality of life (QoL) is still unknown. Thus, we conducted a meta-analysis to compare the QoL of brace-treated AIS patients with untreated AIS patients. The pain, self-image/appearance, mental health, function/activity, satisfaction with management, total score without satisfaction, and total score of patients were used to measure the QoL after the intervention. METHODS: Multiple electronic databases including PubMed, Web of Science, and Embase were searched for all years up to June 30, 2016...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28474285/chyluria-and-chylothorax-after-posterior-selective-fusion-for-adolescent-idiopathic-scoliosis
#8
Alexander A Weening, Bernadette Schurink, Jelle P Ruurda, Richard van Hillegersberg, Ronald L A W Bleys, Moyo C Kruyt
PURPOSE: To describe and discuss the diagnostic and treatment complexity of lymphatic system complications after scoliosis surgery. METHODS: Surgery for adolescent idiopathic scoliosis is very commonly performed with posterior pedicle screw instrumentation. Complications of the anteriorly based lymphatic system are, therefore, rare. We present a case with complications related to the lymphatic system, which have not been reported before after this type of surgery...
May 5, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28474006/curve-flexibility-in-cerebral-palsy-related-neuromuscular-scoliosis-does-the-intraoperative-prone-radiograph-reveal-more-flexibility-than-preoperative-radiographs
#9
Zubair Chaudry, John T Anderson
BACKGROUND: Spinal flexibility is determined preoperatively by manipulating the spine and assessing, radiographically, to what extent the amount of deformity reduces. Quantifying spinal flexibility is important when determining the approach to the planned operation in order to achieve the most optimal spinal correction and balance. Currently, supine traction radiography is a popular method used in patients with severe, cerebral palsy-related neuromuscular scoliosis. The different methods for determining spinal flexibility have been studied extensively in the adolescent idiopathic scoliosis population...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28461686/volumetric-and-fatty-infiltration-imbalance-of-deep-paravertebral-muscles-in-adolescent-idiopathic-scoliosis
#10
Jeng Jiang, Yichen Meng, Xinmeng Jin, Chenglin Zhang, Jianquan Zhao, Ce Wang, Rui Gao, Xuhui Zhou
BACKGROUND Several studies have described the differences in electromyographic activity and histological changes of paravertebral muscles in patients with adolescent idiopathic scoliosis (AIS). However, there is little knowledge about the muscle volumetric and fatty infiltration imbalance of patients with AIS. MATERIAL AND METHODS Thirty-four patients with AIS were evaluated with standardized anteroposterior (AP) and lateral standing films for the location and direction of the apex of scoliosis, coronal Cobb angle, apex vertebra translation, and thoracic kyphosis; and with magnetic resonance imaging (MRI) scan of the spine at the level of T4-L1...
May 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28451507/assessment-of-a-learning-strategy-among-spine-surgeons
#11
Alberto Ofenhejm Gotfryd, Jose Alfredo Corredor, William Jacobsen Teixeira, Delio Eulálio Martins, Jeronimo Milano, Alexandre Sadao Iutaka
STUDY DESIGN: Pilot test, observational study. OBJECTIVE: To evaluate objectively the knowledge transfer provided by theoretical and practical activities during AOSpine courses for spine surgeons. METHODS: During two AOSpine principles courses, 62 participants underwent precourse assessment, which consisted of questions about their professional experience, preferences regarding adolescent idiopathic scoliosis (AIS) classification, and classifying the curves by means of the Lenke classification of two AIS clinical cases...
February 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28449963/sequential-magnetic-resonance-imaging-reveals-individual-level-deformities-of-vertebrae-and-discs-in-the-growing-scoliotic-spine
#12
Bethany E Keenan, Maree T Izatt, Geoffrey N Askin, Robert D Labrom, Damon D Bennett, Mark J Pearcy, Clayton J Adam
STUDY DESIGN: The aim of this study was to measure contributions of individual vertebra and disc wedging to coronal Cobb angle in the growing scoliotic spine using sequential magnetic resonance imaging (MRI). Clinically, the Cobb angle measures the overall curve in the coronal plane but does not measure individual vertebra and disc wedging. It was hypothesized that patients whose deformity progresses will have different patterns of coronal wedging in vertebrae and discs to those of patients whose deformities remain stable...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28449961/risk-factors-of-proximal-junctional-kyphosis-in-adolescent-idiopathic-scoliosis-the-pelvis-and-other-considerations
#13
Baron S Lonner, Yuan Ren, Peter O Newton, Suken A Shah, Amer F Samdani, Harry L Shufflebarger, Jahangir Asghar, Paul Sponseller, Randal R Betz, Burt Yaszay
STUDY DESIGN: Prospective multicenter database study. OBJECTIVES: To assess the incidence of proximal junctional kyphosis (PJK) in operative adolescent idiopathic scoliosis (AIS) using contemporary surgical techniques and to identify risk factors for PJK. SUMMARY OF BACKGROUND DATA: The incidence of PJK has been reported as high as 46% in AIS. Factors associated with PJK have been incompletely explored. METHODS: Prospectively enrolled 851 AIS patients (2000-2011, 78...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28449960/evaluating-the-change-in-axial-vertebral-rotation-following-thoracoscopic-anterior-scoliosis-surgery-using-low-dose-computed-tomography
#14
J Paige Little, Maree T Izatt, Clayton J Adam, Olivia Lofgren, Anna Sundberg, Robert D Labrom, Geoffrey N Askin
BACKGROUND CONTEXT: In recent years, there has been increasing appreciation of the need to treat scoliosis as a three-dimensional deformity. PURPOSE: Assessment of surgical strategies and outcomes should consider not only the coronal plane correction but also derotation of the transverse plane deformity that can affect trunk appearance. STUDY DESIGN: This study included a cohort of 29 female adolescent idiopathic scoliosis patients who received thoracoscopic single rod anterior fusion (TASF) surgery...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28449959/resource-utilization-in-adolescent-idiopathic-scoliosis-surgery-is-there-opportunity-for-standardization
#15
Baron S Lonner, Courtney S Toombs, Justin C Paul, Suken A Shah, Harry L Shufflebarger, John M Flynn, Peter O Newton
INTRODUCTION: Recent healthcare reforms have raised the importance of cost and value in the management of disease. Value is a function of benefit and cost. Understanding variability in resources utilized by individual surgeons to achieve similar outcomes may provide an opportunity for cutting costs though greater standardization. The purpose of this study is to evaluate differences in use of implants and hospital resources among surgeons performing adolescent idiopathic scoliosis (AIS) surgery...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28449958/predicting-3d-thoracic-kyphosis-using-traditional-2d-radiographic-measurements-in-adolescent-idiopathic-scoliosis
#16
Kevin C Parvaresh, Emily J Osborn, Fredrick G Reighard, Joshua Doan, Tracey P Bastrom, Peter O Newton
STUDY DESIGN: Retrospective. OBJECTIVE: To develop and validate a prediction formula to estimate three-dimensional (3D) T5-T12 kyphosis in adolescent idiopathic scoliosis (AIS) from standard two-dimensional (2D) radiographic measurements. SUMMARY OF BACKGROUND DATA: 2D measurements of thoracic kyphosis in AIS patients overestimate 3D kyphosis; however, there is a lack of widespread availability of 3D imaging technology. METHODS: Retrospective review was performed for AIS patients with right thoracic curves evaluated with EOS Imaging from January 2010 to June 2014...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28449957/assessment-of-breast-asymmetry-in-adolescent-idiopathic-scoliosis-using-an-automated-3d-body-surface-measurement-technique
#17
Joyce Ramsay, Lama Seoud, Soraya Barchi, Farida Cheriet, Julie Joncas, Isabelle Turgeon, Philippe Debanné, Isabelle Trop, Hubert Labelle, Stefan Parent
STUDY DESIGN: Cohort study. OBJECTIVES: To assess breast asymmetry (BA) directly with 3D surface imaging and to validate it using MRI values from a cohort of 30 patients with significant adolescent idiopathic scoliosis (AIS). Also, to study the influence of posture (prone vs standing) on BA using the automated method on both modalities. SUMMARY OF BACKGROUND DATA: BA is a common concern in young female patients with AIS. In a previous study using MRI, we found that the majority of patients with significant AIS experienced BA of up to 21% in addition to their chest wall deformity...
May 2017: Spine Deformity
https://www.readbyqxmd.com/read/28443159/genetic-markers-for-adolescent-idiopathic-scoliosis-on-chromosome-19p13-3-among-saudi-arabian-girls
#18
Abdallah Ahmad Al-Othman, Mir Sadat-Ali, Ahmed Sh Amer, Dakheel A Al-Dakheel
STUDY DESIGN: Prospective case-controlled study. PURPOSE: This study aimed to assess genetic influence in Saudi Arabian children with adolescent idiopathic scoliosis (AIS). OVERVIEW OF LITERATURE: The genetic locus linked to chromosome 19p for idiopathic scoliosis has been described. A pilot study conducted at King Fahd Hospital of the University, Al-Khobar showed that three microsatellite markers (D19S216, D19S894, and DS1034) of chromosome 19p13...
April 2017: Asian Spine Journal
https://www.readbyqxmd.com/read/28441684/development-of-consensus-based-best-practice-guidelines-for-postoperative-care-following-posterior-spinal-fusion-for-adolescent-idiopathic-scoliosis
#19
Nicholas D Fletcher, Michael P Glotzbecker, Michelle Marks, Peter O Newton
STUDY DESIGN: Delphi process with multiple iterative rounds using a nominal group technique. OBJECTIVE: The aim of this study was to use expert opinion to achieve consensus on various aspects of postoperative care following posterior spinal fusion (PSF) for adolescent idiopathic scoliosis (AIS). SUMMARY OF BACKGROUND DATA: Significant variability exists in postoperative care following PSF for AIS, despite a relatively healthy patient population and continuously improving operative techniques...
May 1, 2017: Spine
https://www.readbyqxmd.com/read/28441683/geometric-torsion-in-adolescent-idiopathic-scoliosis-a-new-method-to-differentiate-between-lenke-1-subtypes
#20
Jesse Shen, Samuel Kadoury, Hubert Labelle, Marjolaine Roy-Beaudry, Carl-Éric Aubin, Stefan Parent
STUDY DESIGN: Consecutive case series. OBJECTIVE: To study geometric torsion in thoracic adolescent idiopathic scoliosis (AIS) to propose it as a numerical three-dimensional (3D) parameter that quantifies the scoliosis deformity. SUMMARY OF BACKGROUND DATA: AIS is a 3D deformity of the spine. The most widely accepted and used classification systems, however, still rely on two-dimensional aspects of x-rays. Yet, a 3D classification of AIS remains elusive because there is no widely accepted 3D parameter in the clinical practice...
May 1, 2017: Spine
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