Jiahui Zhang, Nanyan Miao, Liyan Lao, Wen Deng, Jiawen Wang, Xiaofeng Zhu, Yongsheng Huang, Huayue Lin, Wenfeng Zeng, Wei Zhang, Luyuan Tan, Xiaoqing Yuan, Xin Zeng, Jingkun Zhu, Xueman Chen, Erwei Song, Linbin Yang, Yan Nie, Di Huang
Basal-like breast cancer (BLBC) is the most aggressive molecular subtype of breast cancer with worse prognosis and fewer treatment options. The underlying mechanisms upon BLBC transcriptional dysregulation and its upstream transcription factors (TFs) remain unclear. Here, among the hyperactive candidate TFs of BLBC identified by bioinformatic analysis, POU4F1 is uniquely upregulated in BLBC and is associated with poor prognosis. POU4F1 is necessary for the tumor growth and malignant phenotypes of BLBC through regulating G1/S transition by direct binding at the promoter of CDK2 and CCND1...
March 16, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)